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Researchers at Tehran University of Medical Sciences conducted a study on the effects of physical exercise on chronic kidney disease (CKD) in rats. The study found that inhibiting hydrogen sulfide production reversed the improvements in kidney function, oxidative stress, and inflammation achieved through exercise. The results suggest that the benefits of exercise in CKD may be partially attributed to CSE/H2S signaling. The research was published in the Iranian Journal of Pharmaceutical Research and has been peer-reviewed. [Extracted from the article]

A study conducted at Nanjing Normal University in Jiangsu, People's Republic of China, focused on the innate immune response of Eriocheir sinensis crabs with black gill syndrome (BGS). The research found that increased hydrogen sulfide (H2S) production induced the expression of antimicrobial peptides (AMPs) through the Toll pathway in the crabs with BGS. This study sheds light on potential strategies for disease prevention and treatment in crustaceans. The findings were published in the journal Fish & Shellfish Immunology and have been peer-reviewed. [Extracted from the article]

Researchers at Vanderbilt University Medical Center have discovered that the enzyme Cystathionine gamma-lyase (CTH) plays a crucial role in colonic inflammation in mice with colitis. The absence of CTH in mice led to improved clinical and histological outcomes, although it did not affect tumorigenesis. The study suggests that targeting CTH could be a potential intervention for patients with inflammatory bowel disease by reshaping the gut microbiota. This research was supported by the Crohn's & Colitis Foundation and Vanderbilt Technologies for Advanced Genomics (VANTAGE) core at VUMC. [Extracted from the article]

A recent study conducted by Kangwon National University in Chuncheon, South Korea, focused on the structural analysis of the CJ0600 protein from Campylobacter jejuni, a bacterium known to cause foodborne enteritis in humans. The research revealed that CJ0600 functions as a unique PLP-dependent enzyme with distinct features not found in its structural homologs. The study concluded that CJ0600 does not exhibit CysDS or SerDA activity and only shows weak AccDA activity, suggesting it operates differently from previously reported enzymes. This research provides valuable insights into the enzymatic activity of CJ0600 and highlights its evolutionary distinctiveness. [Extracted from the article]

Researchers from the Medical University of Sofia have conducted a study on the effects of inhibiting the enzymes cystathionine g-lyase and nitric oxide synthase on food and water intake, body mass gain, and body temperature in rats. The study found that the simultaneous inhibition of these enzymes resulted in a decrease in food and water intake, body mass gain, and body temperature in the rats. These findings contribute to our understanding of the physiological implications of targeting these enzyme pathways. The full study can be accessed for free at the provided link. [Extracted from the article]

A new study conducted at the University of Texas Medical Branch Galveston explores the relationship between cystathionine gamma-lyase (CSE) and TNF-a in regulating intestinal homeostasis, inflammation, and wound healing. The researchers used pharmacological inhibitors and gene silencing techniques to investigate the interactions between CSE and TNF-a in colonic epithelial cells. The study found that CSE and TNF-a mutually regulate each other's functions and that CSE activity is essential for effective TNF-a-mediated intestinal injury response. These findings suggest that targeting CSE and TNF-a-controlled intracellular signaling pathways could be a potential therapeutic approach for diseases of the colon associated with impaired epithelial wound healing. [Extracted from the article]

A recent study conducted by researchers at Capital Medical University in Beijing, China, explored the potential role of cystathionine-gamma-lyase (CSE) as a prognosis biomarker in hepatocellular carcinoma (HCC), a common malignant tumor with poor prognosis. The study analyzed CSE expression in HCC tissues and found lower levels compared to adjacent normal tissues. Decreased CSE expression was associated with advanced clinicopathological features and poor outcomes in HCC patients. In vitro experiments suggested that CSE may trigger HCC cell apoptosis. The findings suggest that CSE could serve as a potential prognostic biomarker and therapeutic target for HCC. [Extracted from the article]

A recent study conducted at Seoul National University in South Korea has found that the natural compound EGCG can inhibit the enzyme MccB in Staphylococcus aureus, a gram-positive bacteria known for its multidrug resistance. The researchers discovered that EGCG forms a hemiacetal compound with pyridoxal phosphate, depleting the cytosolic pool of pyridoxal phosphate and inhibiting H2S production. This finding may have potential applications in diets aimed at suppressing the pathogenesis of S. aureus in the gut using EGCG. The research has been peer-reviewed and published in the journal Food Bioscience. [Extracted from the article]

A study conducted by researchers at Tongji University in Shanghai, China, has found that hydrogen sulfide (H2S) plays a crucial role in protecting against heart failure. The study focused on the interaction between H2S and Sirtuin-1 (SIRT1), a protein that has a protective effect on heart failure. The researchers discovered that H2S treatment improved cardiac function and increased SIRT1 expression. They also found that Cystathionine gamma-Lyase (CSE), an enzyme that generates H2S, S-sulfhydrated SIRT1 and stabilized its structure. These findings suggest a novel mechanism for preventing heart dysfunction. [Extracted from the article]

The article discusses the insulin molecule, a chemical structure of a protein. Protein is insulin, a pancreatic hormone which governs sugar metabolism in the body. This insulin is one of the smallest proteins and is made up of 51 amino acids. One of the components of insulin are three molecules of the amino acid cystine.

Researchers from Louisiana State University Health Sciences Center have published a report on recent findings in biology. The study focuses on the role of reactive sulfur species (RSS) in cellular redox-dependent functions. The researchers discovered that under hypoxic conditions, there is an increase in persulfide and polysulfide production through the phosphorylation of cystathionine gamma lyase (CSE) at specific sites. This phosphorylation is AMP kinase dependent and leads to increased enzyme activity. The findings shed light on the molecular signaling pathways involved in CSE-dependent persulfide and polysulfide production, which have implications for tissue and cellular response to stress. [Extracted from the article]

Keywords: Amino Acids; Angiology; Carbon-Sulfur Lyases; Cystathionine; Cystathionine gamma-Lyase; Diamino Amino Acids; Dicarboxylic Amino Acids; Enzymes and Coenzymes; Health and Medicine; Lyases; Saphenous Vein; Sulfur Amino Acids EN Amino Acids Angiology Carbon-Sulfur Lyases Cystathionine Cystathionine gamma-Lyase Diamino Amino Acids Dicarboxylic Amino Acids Enzymes and Coenzymes Health and Medicine Lyases Saphenous Vein Sulfur Amino Acids 173 173 1 09/25/23 20230928 NES 230928 2023 SEP 28 (NewsRx) -- By a News Reporter-Staff News Editor at Blood Weekly -- Fresh data on amino acids are presented in a new report. Amino Acids, Angiology, Carbon-Sulfur Lyases, Cystathionine, Cystathionine gamma-Lyase, Diamino Amino Acids, Dicarboxylic Amino Acids, Enzymes and Coenzymes, Health and Medicine, Lyases, Sulfur Amino Acids, Saphenous Vein. [Extracted from the article]

In conclusion, this study demonstrates that H2S has an important role in the pathogenesis of sepsis and validates PAG use as a suited tool for investigating the Cth/H2S-signalling axis in sepsis." Keywords: Amino Acids; Biological Factors; Blood Diseases and Conditions; Bloodstream Infection; Carbon-Sulfur Lyases; Chemokines; Cystathionine; Cystathionine gamma-Lyase; Diamino Amino Acids; Dicarboxylic Amino Acids; Endothelial Cells; Enzymes and Coenzymes; Genetics; Health and Medicine; Inflammation Mediators; Lyases; Pharmacology; Sepsis; Septicemia; Sulfur Amino Acids; Therapy EN Amino Acids Biological Factors Blood Diseases and Conditions Bloodstream Infection Carbon-Sulfur Lyases Chemokines Cystathionine Cystathionine gamma-Lyase Diamino Amino Acids Dicarboxylic Amino Acids Endothelial Cells Enzymes and Coenzymes Genetics Health and Medicine Inflammation Mediators Lyases Pharmacology Sepsis Septicemia Sulfur Amino Acids Therapy 307 307 1 09/19/23 20230922 NES 230922 2023 SEP 21 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Current study results on sepsis have been published. [Extracted from the article]

Iron-sulfur clusters are part of the cellular sulfide pool, which functions to maintain cardio-vascular health, and consists of free hydrogen sulfide, iron-sulfur clusters, protein bound sulfides, which constitute the total cellular sulfide fraction." Pioglitazone increased the acid-labile (iron-sulfur cluster) and bound sulfur cellular fractions and reduced cystathionine gamma-lyase enzymatic activity in cells with and without ATM protein expression. [Extracted from the article]

Another possibility for this H2S production is the cystathionine gamma-lyase-catalyzed beta-elimination of cysteine persulfide from cystine, which upon reduction yields H2S and cysteine. Despite this decrease in cysteine levels, these tissues exhibit increased H2S production which is thought to be generated by beta-elimination of the thiol moiety of cysteine, as catalyzed by cystathionine beta-synthase or cystathionine gamma-lyase. [Extracted from the article]

Keywords: Shihezi; People's Republic of China; Asia; Bacterial Polysaccharides; Bacterial Toxins; Biological Factors; Carbon-Sulfur Lyases; Cardiomyopathies; Cardiovascular Diseases and Conditions; Cellular Structures; Chemicals; Cystathionine gamma-Lyase; Cytokines; Cytoplasm; Cytoplasmic Structures; Dehydrogenase; Endoplasmic Reticulum; Endotoxins; Enzymes and Coenzymes; Eukaryotic Initiation Factors; Genetics; Health and Medicine; Heart Disease; Heart Disorders and Diseases; Hydrogen Sulfide; Intercellular Signaling Peptides and Proteins; Interleukins; Intracellular Space; Kinase; Lipopolysaccharides; Lyases; Organelles; Peptide Initiation Factors; Phosphotransferases (Alcohol Group Acceptor); Protein Kinases; Proteins; Sodium Hydrosulfide EN Shihezi People's Republic of China Asia Bacterial Polysaccharides Bacterial Toxins Biological Factors Carbon-Sulfur Lyases Cardiomyopathies Cardiovascular Diseases and Conditions Cellular Structures Chemicals Cystathionine gamma-Lyase Cytokines Cytoplasm Cytoplasmic Structures Dehydrogenase Endoplasmic Reticulum Endotoxins Enzymes and Coenzymes Eukaryotic Initiation Factors Genetics Health and Medicine Heart Disease Heart Disorders and Diseases Hydrogen Sulfide Intercellular Signaling Peptides and Proteins Interleukins Intracellular Space Kinase Lipopolysaccharides Lyases Organelles Peptide Initiation Factors Phosphotransferases (Alcohol Group Acceptor) Protein Kinases Proteins Sodium Hydrosulfide 413 413 1 06/19/23 20230619 NES 230619 2023 JUN 19 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Fresh data on Heart Disorders and Diseases - Cardiomyopathies are presented in a new report. [Extracted from the article]

Keywords: Moscow; Russia; Life Science; Amino Acids; Carbon-Sulfur Lyases; Cystathionine; Cystathionine gamma-Lyase; Diamino Amino Acids; Dicarboxylic Amino Acids; Enzymes and Coenzymes; Lyases; Sulfur Amino Acids EN Moscow Russia Life Science Amino Acids Carbon-Sulfur Lyases Cystathionine Cystathionine gamma-Lyase Diamino Amino Acids Dicarboxylic Amino Acids Enzymes and Coenzymes Lyases Sulfur Amino Acids 4224 4224 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Life Science are presented in a new report. Moscow, Russia, Life Science, Amino Acids, Carbon-Sulfur Lyases, Cystathionine, Cystathionine gamma-Lyase, Diamino Amino Acids, Dicarboxylic Amino Acids, Enzymes and Coenzymes, Lyases, Sulfur Amino Acids. [Extracted from the article]

Keywords: Amino Acids; Bioengineering; Bioinformatics; Biomarkers; Biotechnology; Cancer; Carbon-Sulfur Lyases; Carcinomas; Cystathionine; Cystathionine gamma-Lyase; Diagnostics and Screening; Diamino Amino Acids; Dicarboxylic Amino Acids; Enzymes and Coenzymes; Health and Medicine; Information Technology; Liver Cancer; Lyases; Oncology; Prognostic Markers; Sulfur Amino Acids EN Amino Acids Bioengineering Bioinformatics Biomarkers Biotechnology Cancer Carbon-Sulfur Lyases Carcinomas Cystathionine Cystathionine gamma-Lyase Diagnostics and Screening Diamino Amino Acids Dicarboxylic Amino Acids Enzymes and Coenzymes Health and Medicine Information Technology Liver Cancer Lyases Oncology Prognostic Markers Sulfur Amino Acids 897 897 1 06/05/23 20230606 NES 230606 2023 JUN 6 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Oncology Week -- New research on bioinformatics is the subject of a new report. Amino Acids, Bioengineering, Bioinformatics, Biomarkers, Biotechnology, Cancer, Carbon-Sulfur Lyases, Carcinomas, Cystathionine, Cystathionine gamma-Lyase, Diagnostics and Screening, Diamino Amino Acids, Dicarboxylic Amino Acids, Enzymes and Coenzymes, Health and Medicine, Information Technology, Liver Cancer, Lyases, Oncology, Prognostic Markers, Sulfur Amino Acids. [Extracted from the article]

Keywords for this news article include: Minneapolis, Minnesota, United States, North and Central America, Amino Acids, Carbon-Sulfur Lyases, Chemicals, Cystathionine, Cystathionine gamma-Lyase, Diamino Amino Acids, Dicarboxylic Amino Acids, Elements, Enzymes and Coenzymes, Gases, Hydrogen, Hydrogen Sulfide, Inorganic Chemicals, Lyases, Noncarboxylic Acids, Sulfur Amino Acids, Sulfur Compounds, Sulfur Group Transferases, Sulfurtransferases, Synthase, University of Minnesota. The importance of cystathionine beta-synthase and cystathionine gamma-lyase in hydrogen sulfide biogenesis is well-described, but documentation of the 3-MST pathway is limited. Keywords: Minneapolis; State:Minnesota; United States; North and Central America; Amino Acids; Carbon-Sulfur Lyases; Chemicals; Cystathionine; Cystathionine gamma-Lyase; Diamino Amino Acids; Dicarboxylic Amino Acids; Elements; Enzymes and Coenzymes; Gases; Hydrogen; Hydrogen Sulfide; Inorganic Chemicals; Lyases; Noncarboxylic Acids; Sulfur Amino Acids; Sulfur Compounds; Sulfur Group Transferases; Sulfurtransferases; Synthase EN Minneapolis State:Minnesota United States North and Central America Amino Acids Carbon-Sulfur Lyases Chemicals Cystathionine Cystathionine gamma-Lyase Diamino Amino Acids Dicarboxylic Amino Acids Elements Enzymes and Coenzymes Gases Hydrogen Hydrogen Sulfide Inorganic Chemicals Lyases Noncarboxylic Acids Sulfur Amino Acids Sulfur Compounds Sulfur Group Transferases Sulfurtransferases Synthase 1994 1994 1 04/24/23 20230428 NES 230428 2023 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Enzymes and Coenzymes - Sulfur Group Transferases. [Extracted from the article]

Human CBS promoter contains multiple estrogen-responsive elements (EREs), including one ERE preferentially binding ER alpha (alpha ERE) and three EREs preferentially binding ER beta (beta ERE), and one full ERE (alpha/beta ERE) and one half ERE (1/2 alpha/beta ERE) binding both ER alpha and ER beta. E-2 beta stimulated ER alpha/ER beta heterodimerization by recruiting ER alpha to alpha/beta EREs and beta ERE, and ER beta to beta ERE, alpha/beta EREs, and alpha ERE. Luciferase assays using reporter genes driven by human CBS promoter with a series of 5 & PRIME;-deletions identified the alpha/beta EREs binding both ER alpha and ER beta (alpha/beta ERE and 1/2 alpha/beta ERE) to be important for baseline and E-2 beta-stimulated CBS promoter activation. [Extracted from the article]

For more information on this research see: Cystathionine Gamma-lyase and Hydrogen Sulfide Modulates Glucose Transporter Glut1 Expression Via Nf-kappa B and Pi3k/akt In Macrophages During Inflammation. Keywords: Fairbanks; State:Alaska; United States; North and Central America; Amino Acids; Carbon-Sulfur Lyases; Chemicals; Connective Tissue Cells; Cystathionine; Cystathionine gamma-Lyase; DNA-Binding Proteins; Diamino Amino Acids; Dicarboxylic Amino Acids; Elements; Enzymes and Coenzymes; Gases; Health and Medicine; Hydrogen; Hydrogen Sulfide; Immunology; Inflammation; Inorganic Chemicals; Lyases; Macrophages; Mononuclear Phagocyte System; Myeloid Cells; NF-kappa B; Noncarboxylic Acids; Nuclear Proteins; Phagocytes; Proteins; Sulfur Amino Acids; Sulfur Compounds; Transcription Factors EN Fairbanks State:Alaska United States North and Central America Amino Acids Carbon-Sulfur Lyases Chemicals Connective Tissue Cells Cystathionine Cystathionine gamma-Lyase DNA-Binding Proteins Diamino Amino Acids Dicarboxylic Amino Acids Elements Enzymes and Coenzymes Gases Health and Medicine Hydrogen Hydrogen Sulfide Immunology Inflammation Inorganic Chemicals Lyases Macrophages Mononuclear Phagocyte System Myeloid Cells NF-kappa B Noncarboxylic Acids Nuclear Proteins Phagocytes Proteins Sulfur Amino Acids Sulfur Compounds Transcription Factors 7562 7562 1 03/23/23 20230317 NES 230317 2023 MAR 17 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Proteins - Transcription Factors. [Extracted from the article]

Scientists at the New York University School of Medicine have uncovered an innate defense mechanism that protects bacteria from normally lethal doses of antibiotics. A drug inhibiting an enzyme called cystathionine gamma-lyase enhanced the effect of antibiotics in mice. [ABSTRACT FROM AUTHOR]

The article reports on a research that examines the effect of hydrogen sulfide on the penile nerves. Researchers Giuseppe Cirino and his colleagues investigate the association of hydrogen sulfide with the erection of penis. After obtaining penis tissue from eight sex-change operations, they found that not only does the tissue harbor cystathionine beta-synthase and cystathionine gamma-lyase (CSE), but CSE is also present in the smooth muscle cells and peripheral nerves that control erection.