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A recent study conducted at Quaid-i-Azam University in Islamabad, Pakistan, focused on synthesizing a series of adamantane-linked aminothiazole derivatives and evaluating their enzyme inhibitory activities. The compounds were characterized using various spectroscopic techniques and were found to have inhibitory effects on enzymes such as urease, alpha-glucosidase, and carbonic anhydrase. The study suggests that these compounds have potential medicinal importance and highlights the significance of structure-activity relationships in developing potent enzyme inhibitors. The research was financially supported by King Saud University. [Extracted from the article]

Researchers at Government College University Faisalabad in Pakistan have synthesized a library of biphenyl-4-carboxamide derivatives and tested them for their anticancer, antimicrobial, and enzyme inhibition activities. The compound 4h showed the most activity against human liver cancer cells, while compound 4c demonstrated potent inhibitory activity against acetylcholinesterase and urease enzymes. The synthesized compounds also exhibited antibacterial and antifungal activities. Molecular docking studies revealed that the compounds had good binding capability with the target enzymes. The researchers concluded that these compounds have potential as pharmaceutical agents. [Extracted from the article]

A recent study conducted at the Affiliated Hospital of Putian University explores the role of sirtuins in intervertebral disc degeneration (IVDD). IVDD is a common cause of lower back pain, particularly in older individuals. The study reviews the literature on the effects of sirtuins and their activators on IVDD, focusing on their impact on senescence, inflammatory responses, oxidative stress, and mitochondrial dysfunction in myeloid cells. The research suggests that sirtuins and their activators have positive effects against IVDD and may hold potential for further treatment development. [Extracted from the article]

Recent research demonstrates that Echinacea possesses cannabimimetic activity with potential applications beyond common contemporary uses for relief of cold and flu symptoms. In this study, we investigated the in vitro inhibitory effect of root extracts of Echinacea purpurea and Echinacea angustifolia on fatty acid amide hydrolase, the main enzyme that degrades the endocannabinoid anandamide. The objective was to relate variation in bioactivity between commercial Echinacea genotypes to their phytochemical profiles and to identify determinants of activity using biochemometric analysis. Forty root extracts of each of species were tested for inhibition of fatty acid amide hydrolase and analyzed by HPLC-DAD/MS to identify and quantitate alkylamides and caffeic acid derivatives. Fatty acid amide hydrolase inhibition ranged from 34 – 80% among E. angustifolia genotypes and from 33 – 87% among E. purpurea genotypes. Simple linear regression revealed the caffeic acid derivatives caftaric acid and cichoric acid, and the alkylamide dodeca-2 E ,4 Z -diene-8,10-diynioc acid 2-methylbutylamide, as the strongest determinants of inhibition in E. purpurea (r* = 0.53, 0.45, and 0.20, respectively) while in E. angustifolia , only CADs were significantly associated with activity, most notably echinacoside (r* = 0.26). Regression analysis using compound groups generated by hierarchical clustering similarly indicated that caffeic acid derivatives contributed more than alkylamides to in vitro activity. Testing pure compounds identified as determinants of activity revealed cichoric acid (IC50 = 45 ± 4 µM) and dodeca-2 E ,4 E ,8 Z ,10 E -tetraenoic acid isobutylamide (IC50 = 54 ± 2 µM) as the most active. The results suggest that several phytochemicals may contribute to Echinaceaʼs cannabimimetic activity and that ample variation in genotypes exists for selection of high-activity germplasm in breeding programs. [ABSTRACT FROM AUTHOR]

Keywords: Amidohydrolases; Cancer; Deacetylase; Drugs and Therapies; Enzymes and Coenzymes; Health and Medicine; Histone Deacetylases; Histones; Nucleoproteins; Oncology; Proteins; Rhabdomyosarcomas EN Amidohydrolases Cancer Deacetylase Drugs and Therapies Enzymes and Coenzymes Health and Medicine Histone Deacetylases Histones Nucleoproteins Oncology Proteins Rhabdomyosarcomas 1225 1225 1 09/04/23 20230904 NES 230904 2023 SEP 4 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- Research findings on rhabdomyosarcomas are discussed in a new report. Amidohydrolases, Cancer, Deacetylase, Drugs and Therapies, Enzymes and Coenzymes, Health and Medicine, Histone Deacetylases, Histones, Nucleoproteins, Oncology, Proteins, Rhabdomyosarcomas. [Extracted from the article]

Keywords: Muscat; Oman; Asia; Life Science; Amidohydrolases; Enzymes and Coenzymes; Urease EN Muscat Oman Asia Life Science Amidohydrolases Enzymes and Coenzymes Urease 2076 2076 1 05/29/23 20230602 NES 230602 2023 JUN 2 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Life Science. Keywords for this news article include: Muscat, Oman, Asia, Life Science, Amidohydrolases, Enzymes and Coenzymes, Urease, Sultan Qaboos University. [Extracted from the article]