Study Results from Affiliated Hospital of Putian University Update Understanding of Sirtuins (Sirtuins in intervertebral disc degeneration: current understanding).

A recent study conducted at the Affiliated Hospital of Putian University explores the role of sirtuins in intervertebral disc degeneration (IVDD). IVDD is a common cause of lower back pain, particularly in older individuals. The study reviews the literature on the effects of sirtuins and their activators on IVDD, focusing on their impact on senescence, inflammatory responses, oxidative stress, and mitochondrial dysfunction in myeloid cells. The research suggests that sirtuins and their activators have positive effects against IVDD and may hold potential for further treatment development. [Extracted from the article]