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1. The Large Hadron–Electron Collider at the HL-LHC

Author: Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, Zurita, P, Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, and Zurita, P
Abstract: The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron–proton and proton–proton operations. This report represents an update to the LHeC’s conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton–nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron–hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.
Published: 2024

2. The Large Hadron–Electron Collider at the HL-LHC

Author: Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, Zurita, P, Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, and Zurita, P
Abstract: The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron–proton and proton–proton operations. This report represents an update to the LHeC’s conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton–nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron–hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.
Published: 2024

3. The Large Hadron–Electron Collider at the HL-LHC

Author: Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, Zurita, P, Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, and Zurita, P
Abstract: The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron–proton and proton–proton operations. This report represents an update to the LHeC’s conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton–nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron–hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.
Published: 2024

4. Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., Niemi, Mikko, Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
Abstract: Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1 were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1 c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1 c.629G>T (p.210G>V) causes a loss of function of OATP1
Published: 2023
Full Text: View/download PDF

5. Expected sensitivity on the anomalous quartic neutral gauge couplings in $\gamma\gamma$ collisions at the CLIC

Author: Gurkanli, E., Köksal, M., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., Ari, V., Gurkanli, E., Köksal, M., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., and Ari, V.
Abstract: The presence of multi-boson self-interactions is implied by the non-Abelian gauge structure of the Standard Model (SM). Precise measurements of these interactions allow not only testing the nature of the SM but also new physics contribution arising from the beyond SM. The investigation of these interactions can be approached in a model-independent manner using an effective theory approach, which forms the main motivation of this study. In this paper, we examine the anomalous neutral quartic gauge couplings through the process $\gamma \gamma \rightarrow Z Z$ at the Compact Linear Collider (CLIC) with the center-of-mass energy of $\sqrt{s}=3$ TeV, integrated luminosities of ${\cal L}=5$ $\rm ab^{-1}$. The anomalous neutral quartic gauge couplings is implemented into FeynRules to generate a UFO module inserted into Madgraph to generate both background and signal events. These events are then passed through Pythia 8 for parton showering and Delphes to include realistic detector effects. We obtain that the sensitivities on the anomalous quartic neutral gauge couplings with $95\%$ Confidence Level are given as: $f_{T0}/\Lambda^{4}=[-1.06; 1.08]\times 10^{-3}$ ${\rm TeV^{-4}}$, $f_{T1}/\Lambda^{4}=[-1.06; 1.08]\times 10^{-3}$ ${\rm TeV^{-4}}$,$f_{T2}/\Lambda^{4}=[-1.06; 1.08]\times 10^{-3}$ ${\rm TeV^{-4}}$,$f_{T0}/\Lambda^{4}=[-1.06; 1.08]\times 10^{-3}$ ${\rm TeV^{-4}}$, $f_{T5}/\Lambda^{4}=[-4.08; 4.08]\times 10^{-4}$ ${\rm TeV^{-4}}$ and $f_{T8}/\Lambda^{4}=[-1.10; 1.10]\times10^{-4}$ ${\rm TeV^{-4}}$. Our results on the anomalous quartic neutral gauge couplings are set more stringent sensitivity with respect to the recent experimental limits., Comment: 20 pages, 6 figures
Published: 2023

6. Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., Niemi, Mikko, Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
Abstract: Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1 were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1 c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1 c.629G>T (p.210G>V) causes a loss of function of OATP1
Published: 2023
Full Text: View/download PDF

7. Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., Niemi, Mikko, Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
Abstract: Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1 were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1 c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1 c.629G>T (p.210G>V) causes a loss of function of OATP1
Published: 2023
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8. Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., Niemi, Mikko, Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
Abstract: Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1 were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1 c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1 c.629G>T (p.210G>V) causes a loss of function of OATP1
Published: 2023
Full Text: View/download PDF

9. Functional characterization of six SLCO1B1 (OATP1B1) variants observed in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., Niemi, Mikko, Häkkinen, Katja, Kiander, Wilma, Kidron, Heidi, Lähteenvuo, Markku, Urpa, Lea, Lintunen, Jonne, Vellonen, Kati-Sisko, Auriola, Seppo, Holm, Minna, Lahdensuo, Kaisla, Kampman, Olli, Isometsä, Erkki, Kieseppä, Tuula, Lönnqvist, Jouko, Suvisaari, Jaana, Hietala, Jarmo, Tiihonen, Jari, Palotie, Aarno, Ahola-Olli, Ari V., and Niemi, Mikko
Abstract: Variants in the SLCO1B1 (solute carrier organic anion transporter family member 1B1) gene encoding the OATP1B1 (organic anion transporting polypeptide 1B1) protein are associated with altered transporter function that can predispose patients to adverse drug effects with statin treatment. We explored the effect of six rare SLCO1B1 single nucleotide variants (SNVs) occurring in Finnish individuals with a psychotic disorder on expression and functionality of the OATP1B1 protein. The SUPER-Finland study has performed exome sequencing on 9381 individuals with at least one psychotic episode during their lifetime. SLCO1B1 SNVs were annotated with PHRED-scaled combined annotation-dependent (CADD) scores and the Ensembl variant effect predictor. In vitro functionality studies were conducted for the SNVs with a PHRED-scaled CADD score of >10 and predicted to be missense. To estimate possible changes in transport activity caused by the variants, transport of 2′,7′-dichlorofluorescein (DCF) in OATP1B1-expressing HEK293 cells was measured. According to the findings, additional tests with rosuvastatin and estrone sulfate were conducted. The amount of OATP1B1 in crude membrane fractions was quantified using a liquid chromatography tandem mass spectrometry-based quantitative targeted absolute proteomics analysis. Six rare missense variants of SLCO1B1 were identified in the study population, located in transmembrane helix 3: c.317T>C (p.106I>T), intracellular loop 2: c.629G>T (p.210G>V), c.633A>G (p.211I>M), c.639T>A (p.213N>L), transmembrane helix 6: 820A>G (p.274I>V), and the C-terminal end: 2005A>C (p.669N>H). Of these variants, SLCO1B1 c.629G>T (p.210G>V) resulted in the loss of in vitro function, abolishing the uptake of DCF, estrone sulfate, and rosuvastatin and reducing the membrane protein expression to 31% of reference OATP1B1. Of the six rare missense variants, SLCO1B1 c.629G>T (p.210G>V) causes a loss of function of OATP1
Published: 2023
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10. Investigating Top-Higgs FCNC Couplings at the FCC-hh

Author: Ozsimsek, O. M., Ari, V., Cakir, O., Ozsimsek, O. M., Ari, V., and Cakir, O.
Abstract: We have studied the sensitivity to flavor changing neutral current interaction of top and Higgs boson at the future circular collider in the hadron-hadron collision mode (FCC-hh). Our main concerns are the processes of $pp\rightarrow th$ (FCNC production) and $pp\rightarrow t\bar{t}$ (one top FCNC decay) which contributes to the single lepton, at least three jets and the missing energy transverse in the final state. On the one hand FCC-hh offers very high luminosity and large cross section for these signal processes, on the other hand signal can be distinguished from background which needs application of ingenious methods. Here, we have inspired and followed the searches at the LHC using our analysis path and enhanced attainable limits obtained on the possible top-Higgs FCNC couplings phenomenologically. We obtain new limits which are beyond the current experimental limits obtained from different channels and processes at the LHC. The potential discovery or exclusion limits on branching ratios for $tqH$ FCNC interactions can be set $BR(\eta_{uc})_{\mathrm{disc}}=9.08\times10^{-6}$ or $BR(\eta_{uc})_{\mathrm{exc}}=2.78\times10^{-6}$ at an integrated luminosity of 30 ab$^{-1}$ , respectively. Our results are compatible with the other channels already studied at FCC-hh., Comment: 15 pages, 29 figures
Published: 2022

11. Projected Sensivity to Dimension-6 Triple Gauge Couplings at the FCC-hh

Author: Ari, V., Cetinkaya, V., Köksal, M., Cakir, O., Ari, V., Cetinkaya, V., Köksal, M., and Cakir, O.
Abstract: In this study, we investigate the process pp \rightarrow W^{\pm} \gamma+X for the physics potential of the FCC-hh with \sqrt{s}=100 TeV to examine the anomalous WW\gamma couplings defined by three CP-conserving and two CP-violating effective operators of dimension-6. The analysis containing the realistic detector effects is carried out in the mode where W^{\pm} bosons in the final state decay into the leptonic channel. The best sensitivities obtained from the process pp \rightarrow W^{\pm} \gamma+X TeV^{-2}, [-0.88; 0.88] TeV^{-2} and [-1.12; 1.23] TeV^{-2}, while C_{\tilde{W}WW}/ \Lambda^{2} and C_{\tilde{W}}/ \Lambda^{2} couplings defined by CP-violating effective Lagrangian are obtained as [-0.03; 0.03] TeV^{-2} and [-0.47; 0.47] TeV^{-2} at the FCC-hh with \sqrt{s}=100 TeV, L_{int}=30 ab^{-1}. However, if the systematic uncertainty is included, we obtain reduced sensitivities on the anomalous WW\gamma couplings . The results are compared for assumed systematics of 5\% and 10\%., Comment: 15 pages, 6 Figures and Tables IV
Published: 2022

12. Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder

Author: Häkkinen, K. (Katja), Kiiski, J. I. (Johanna I.), Lähteenvuo, M. (Markku), Jukuri, T. (Tuomas), Suokas, K. (Kimmo), Niemi-Pynttäri, J. (Jussi), Kieseppä, T. (Tuula), Männynsalo, T. (Teemu), Wegelius, A. (Asko), Haaki, W. (Willehard), Lahdensuo, K. (Kaisla), Kajanne, R. (Risto), Kaunisto, M. A. (Mari A.), Tuulio-Henriksson, A. (Annamari), Kampman, O. (Olli), Hietala, J. (Jarmo), Veijola, J. (Juha), Lönnqvist, J. (Jouko), Isometsä, E. (Erkki), Paunio, T. (Tiina), Suvisaari, J. (Jaana), Kalso, E. (Eija), Niemi, M. (Mikko), Tiihonen, J. (Jari), Daly, M. (Mark), Palotie, A. (Aarno), Ahola-Olli, A. V. (Ari V.), Häkkinen, K. (Katja), Kiiski, J. I. (Johanna I.), Lähteenvuo, M. (Markku), Jukuri, T. (Tuomas), Suokas, K. (Kimmo), Niemi-Pynttäri, J. (Jussi), Kieseppä, T. (Tuula), Männynsalo, T. (Teemu), Wegelius, A. (Asko), Haaki, W. (Willehard), Lahdensuo, K. (Kaisla), Kajanne, R. (Risto), Kaunisto, M. A. (Mari A.), Tuulio-Henriksson, A. (Annamari), Kampman, O. (Olli), Hietala, J. (Jarmo), Veijola, J. (Juha), Lönnqvist, J. (Jouko), Isometsä, E. (Erkki), Paunio, T. (Tiina), Suvisaari, J. (Jaana), Kalso, E. (Eija), Niemi, M. (Mikko), Tiihonen, J. (Jari), Daly, M. (Mark), Palotie, A. (Aarno), and Ahola-Olli, A. V. (Ari V.)
Abstract: We demonstrate that CYP2D6 copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and CYP2D6 CNV data from the Breast Cancer Pain Genetics study to construct an imputation panel (n = 902) for CYP2D6 CNV. The resulting data set was used as a CYP2D6 CNV imputation panel in 9262 non-related individuals from the SUPER-Finland study. Based on imputation of 9262 individuals we confirm the higher frequency of CYP2D6 ultrarapid metabolizers and a 22-fold enrichment of the UGT1A1 decreased function variant rs4148323 (UGT1A1*6) in Finland compared with non-Finnish Europeans. Similarly, the NUDT15 variant rs116855232 was highly enriched in Finland. We demonstrate that imputation of CYP2D6 CNV is possible and the methodology enables studying CYP2D6 in large biobanks with genome-wide data.
Published: 2022

13. Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, Ahola-Olli, Ari V., Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, and Ahola-Olli, Ari V.
Abstract: We demonstrate that CYP2D6 copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and CYP2D6 CNV data from the Breast Cancer Pain Genetics study to construct an imputation panel (n = 902) for CYP2D6 CNV. The resulting data set was used as a CYP2D6 CNV imputation panel in 9262 non-related individuals from the SUPER-Finland study. Based on imputation of 9262 individuals we confirm the higher frequency of CYP2D6 ultrarapid metabolizers and a 22-fold enrichment of the UGT1A1 decreased function variant rs4148323 (UGT1A1*6) in Finland compared with non-Finnish Europeans. Similarly, the NUDT15 variant rs116855232 was highly enriched in Finland. We demonstrate that imputation of CYP2D6 CNV is possible and the methodology enables studying CYP2D6 in large biobanks with genome-wide data.
Published: 2022
Full Text: View/download PDF

14. Implementation of CYP2D6 copy-number imputation panel and frequency of key pharmacogenetic variants in Finnish individuals with a psychotic disorder

Author: Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, Ahola-Olli, Ari V., Häkkinen, Katja, Kiiski, Johanna I., Lähteenvuo, Markku, Jukuri, Tuomas, Suokas, Kimmo, Niemi-Pynttäri, Jussi, Kieseppä, Tuula, Männynsalo, Teemu, Wegelius, Asko, Haaki, Willehard, Lahdensuo, Kaisla, Kajanne, Risto, Kaunisto, Mari A., Tuulio-Henriksson, Annamari, Kampman, Olli, Hietala, Jarmo, Veijola, Juha, Lönnqvist, Jouko, Isometsä, Erkki, Paunio, Tiina, Suvisaari, Jaana, Kalso, Eija, Niemi, Mikko, Tiihonen, Jari, Daly, Mark, Palotie, Aarno, and Ahola-Olli, Ari V.
Abstract: We demonstrate that CYP2D6 copy-number variation (CNV) can be imputed using existing imputation algorithms. Additionally, we report frequencies of key pharmacogenetic variants in individuals with a psychotic disorder from the genetically bottle-necked population of Finland. We combined GWAS chip and CYP2D6 CNV data from the Breast Cancer Pain Genetics study to construct an imputation panel (n = 902) for CYP2D6 CNV. The resulting data set was used as a CYP2D6 CNV imputation panel in 9262 non-related individuals from the SUPER-Finland study. Based on imputation of 9262 individuals we confirm the higher frequency of CYP2D6 ultrarapid metabolizers and a 22-fold enrichment of the UGT1A1 decreased function variant rs4148323 (UGT1A1*6) in Finland compared with non-Finnish Europeans. Similarly, the NUDT15 variant rs116855232 was highly enriched in Finland. We demonstrate that imputation of CYP2D6 CNV is possible and the methodology enables studying CYP2D6 in large biobanks with genome-wide data.
Published: 2022
Full Text: View/download PDF

15. HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4

Author: Abada, A, Abbrescia, M, Abdussalam, S, Abdyukhanov, I, Abelleira Fernandez, J, Abramov, A, Aburaia, M, Acar, A, Adzic, P, Agrawal, P, Aguilar-Saavedra, J, Aguilera-Verdugo, J, Aiba, M, Aichinger, I, Aielli, G, Akay, A, Akhundov, A, Aksakal, H, Albacete, J, Albergo, S, Alekou, A, Aleksa, M, Aleksan, R, Alemany Fernandez, R, Alexahin, Y, Alia, R, Alioli, S, Alipour Tehrani, N, Allanach, B, Allport, P, Altinli, M, Altmannshofer, W, Ambrosio, G, Amorim, D, Amstutz, O, Anderlini, L, Andreazza, A, Andreini, M, Andriatis, A, Andris, C, Andronic, A, Angelucci, M, Antinori, F, Antipov, S, Antonelli, M, Antonello, M, Antonioli, P, Antusch, S, Anulli, F, Apolinario, L, Apollinari, G, Apollonio, A, Appelo, D, Appleby, R, Apyan, A, Arbey, A, Arbuzov, A, Arduini, G, Ari, V, Arias, S, Armesto, N, Arnaldi, R, Arsenyev, S, Arzeo, M, Asai, S, Aslanides, E, Assmann, R, Astapovych, D, Atanasov, M, Atieh, S, Attie, D, Auchmann, B, Audurier, A, Aull, S, Aumon, S, Aune, S, Avino, F, Avrillaud, G, Aydin, G, Azatov, A, Azuelos, G, Azzi, P, Azzolini, O, Azzurri, P, Bacchetta, N, Bacchiocchi, E, Bachacou, H, Baek, Y, Baglin, V, Bai, Y, Baird, S, Baker, M, Baldwin, M, Ball, A, Ballarino, A, Banerjee, S, Barber, D, Barducci, D, Barjhoux, P, Barna, D, Barnafoldi, G, Barnes, M, Barr, A, Barranco Garcia, J, Barreiro Guimaraes da Costa, J, Bartmann, W, Baryshevsky, V, Barzi, E, Bass, S, Bastianin, A, Baudouy, B, Bauer, F, Bauer, M, Baumgartner, T, Bautista-Guzman, I, Bayindir, C, Beaudette, F, Bedeschi, F, Beguin, M, Bellafont, I, Bellagamba, L, Bellegarde, N, Belli, E, Bellingeri, E, Bellini, F, Bellomo, G, Belomestnykh, S, Bencivenni, G, Benedikt, M, Bernardi, G, Bernardi, J, Bernet, C, Bernhardt, J, Bernini, C, Berriaud, C, Bertarelli, A, Bertolucci, S, Besana, M, Besancon, M, Beznosov, O, Bhat, P, Bhat, C, Biagini, M, Biarrotte, J, Bibet Chevalier, A, Bielert, E, Biglietti, M, Bilei, G, Bilki, B, Biscari, C, Bishara, F, Blanco-Garcia, O, Blanquez, F, Blekman, F, Blondel, A, Blumlein, J, Boccali, T, Boels, R, Bogacz, S, Bogomyagkov, A, Boine-Frankenheim, O, Boland, M, Bologna, S, Bolukbasi, O, Bomben, M, Bondarenko, S, Bonvini, M, Boos, E, Bordini, B, Bordry, F, Borghello, G, Borgonovi, L, Borowka, S, Bortoletto, D, Boscherini, D, Boscolo, M, Boselli, S, Bosley, R, Bossu, F, Botta, C, Bottura, L, Boughezal, R, Boutin, D, Bovone, G, Bozovic Jelisavic, I, Bozbey, A, Bozzi, C, Bozzini, D, Braccini, V, Braibant-Giacomelli, S, Bramante, J, Braun-Munzinger, P, Briffa, J, Britzger, D, Brodsky, S, Brooke, J, Bruce, R, Bruckman De Renstrom, P, Bruna, E, Bruning, O, Brunner, O, Brunner, K, Bruzzone, P, Buffat, X, Bulyak, E, Burkart, F, Burkhardt, H, Burnet, J, Butin, F, Buttazzo, D, Butterworth, A, Caccia, M, Cai, Y, Caiffi, B, Cairo, V, Cakir, O, Calaga, R, Calatroni, S, Calderini, G, Calderola, G, Caliskan, A, Calvet, D, Calviani, M, Camalich, J, Camarri, P, Campanelli, M, Camporesi, T, Canbay, A, Canepa, A, Cantergiani, E, Cantore-Cavalli, D, Capeans, M, Cardarelli, R, Cardella, U, Cardini, A, Carloni Calame, C, Carra, F, Carra, S, Carvalho, A, Casalbuoni, S, Casas, J, Cascella, M, Castelnovo, P, Castorina, G, Catalano, G, Cavasinni, V, Cazzato, E, Cennini, E, Cerri, A, Cerutti, F, Cervantes, J, Chaikovska, I, Chakrabortty, J, Chala, M, Chamizo-Llatas, M, Chanal, H, Chanal, D, Chance, S, Chance, A, Charitos, P, Charles, J, Charles, T, Chattopadhyay, S, Chehab, R, Chekanov, S, Chen, N, Chernoded, A, Chetvertkova, V, Chevalier, L, Chiarelli, G, Chiarello, G, Chiesa, M, Chiggiato, P, Childers, J, Chmielinska, A, Cholakian, A, Chomaz, P, Chorowski, M, Chou, W, Chrzaszcz, M, Chyhyrynets, E, Cibinetto, G, Ciftci, A, Ciftci, R, Cimino, R, Ciuchini, M, Clark, P, Coadou, Y, Cobal, M, Coccaro, A, Cogan, J, Cogneras, E, Collamati, F, Colldelram, C, Collier, P, Collot, J, Contino, R, Conventi, F, Cook, C, Cooley, L, Corcella, G, Cornell, A, Corral, G, Correia-Rodrigues, H, Costanza, F, Costa Pinto, P, Couderc, F, Coupard, J, Craig, N, Crespo Garrido, I, Crivellin, A, Croteau, J, Crouch, M, Cruz Alaniz, E, Cure, B, Curti, J, Curtin, D, Czech, M, Dachauer, C, D'Agnolo, R, Daibo, M, Dainese, A, Dalena, B, Daljevec, A, Dallapiazza, W, D'Aloia Schwartzentruber, L, Dam, M, D'Ambrosio, G, Das, S, Dasbakshi, S, da Silva, W, da Silveira, G, D'Auria, V, D'Auria, S, David, A, Davidek, T, Deandrea, A, de Blas, J, Debono, C, De Curtis, S, De Filippis, N, de Florian, D, Deghaye, S, de Jong, S, Del Bo, C, Del Duca, V, Delikaris, D, Deliot, F, Dell'Acqua, A, Delle Rose, L, Delmastro, M, De Lucia, E, Demarteau, M, Denegri, D, Deniau, L, Denisov, D, Denizli, H, Denner, A, D'Enterria, D, de Rijk, G, De Roeck, A, Derue, F, Deschamps, O, Descotes-Genon, S, Dev, P, de Vivie de Regie, J, Dewanjee, R, Di Ciaccio, A, Di Cicco, A, Dillon, B, Di Micco, B, Di Nezza, P, Di Vita, S, Doblhammer, A, Dominjon, A, D'Onofrio, M, Dordei, F, Drago, A, Draper, P, Drasal, Z, Drewes, M, Duarte, L, Dubovyk, I, Duda, P, Dudarev, A, Dudko, L, Duellmann, D, Dunser, M, du Pree, T, Durante, M, Duran Yildiz, H, Dutta, S, Duval, F, Duval, J, Dydyshka, Y, Dziewit, B, Eisenhardt, S, Eisterer, M, Ekelof, T, El Khechen, D, Ellis, S, Ellis, J, Ellison, J, Elsener, K, Elsing, M, Enari, Y, Englert, C, Eriksson, H, Eskola, K, Esposito, L, Etisken, O, Etzion, E, Fabbricatore, P, Falkowski, A, Falou, A, Faltova, J, Fan, J, Fano, L, Farilla, A, Farinelli, R, Farinon, S, Faroughy, D, Fartoukh, S, Faus-Golfe, A, Fawcett, W, Felici, G, Felsberger, L, Ferdeghini, C, Fernandez Navarro, A, Fernandez-Tellez, A, Ferradas Troitino, J, Ferrara, G, Ferrari, R, Ferreira, L, Ferreira da Silva, P, Ferrera, G, Ferro, F, Fiascaris, M, Fiorendi, S, Fiorio, C, Fischer, O, Fischer, E, Flieger, W, Florio, M, Fonnesu, D, Fontanesi, E, Foppiani, N, Foraz, K, Forkel-Wirth, D, Forte, S, Fouaidy, M, Fournier, D, Fowler, T, Fox, J, Francavilla, P, Franceschini, R, Franchino, S, Franco, E, Freitas, A, Fuks, B, Furukawa, K, Furuseth, S, Gabrielli, E, Gaddi, A, Galanti, M, Gallo, E, Ganjour, S, Gao, J, Garcia Diaz, V, Garcia Perez, M, Garcia Tabares, L, Garion, C, Garzelli, M, Garzia, I, Gascon-Shotkin, S, Gaudio, G, Gay, P, Ge, S, Gehrmann, T, Genest, M, Gerard, R, Gerigk, F, Gerwig, H, Giacomelli, P, Giagu, S, Gianfelice-Wendt, E, Gianotti, F, Giffoni, F, Gilardoni, S, Gil Costa, M, Giovannetti, M, Giovannozzi, M, Giubellino, P, Giudice, G, Giunta, A, Gladilin, L, Glukhov, S, Gluza, J, Gobbi, G, Goddard, B, Goertz, F, Golling, T, Goncalves, V, Goncalo, R, Gonzalez Gomez, L, Gorgi Zadeh, S, Gorine, G, Gorini, E, Gourlay, S, Gouskos, L, Grancagnolo, F, Grassellino, A, Grau, A, Graverini, E, Gray, H, Greco, M, Grenard, J, Grimm, O, Grojean, C, Gromov, V, Grosse-Oetringhaus, J, Grudiev, A, Grzanka, K, Gu, J, Guadagnoli, D, Guidi, V, Guiducci, S, Guillermo Canton, G, Gunaydin, Y, Gupta, R, Gutierrez, J, Gutleber, J, Guyot, C, Guzey, V, Gwenlan, C, Haberstroh, C, Hacisahinoglu, B, Haerer, B, Hahn, K, Hahn, T, Hammad, A, Han, C, Hance, M, Hannah, A, Harris, P, Hati, C, Haug, S, Hauptman, J, Haurylavets, V, He, H, Hegglin, A, Hegner, B, Heinemann, K, Heinemeyer, S, Helsens, C, Henriques, A, Hernandez, P, Hernandez-Pinto, R, Hernandez-Sanchez, J, Herzig, T, Hiekkanen, I, Hillert, W, Hoehn, T, Hofer, M, Hofle, W, Holdener, F, Holleis, S, Holzer, B, Hong, D, Honorato, C, Hopkins, S, Hrdinka, J, Hug, F, Humann, B, Humer, H, Hurth, T, Hutton, A, Iacobucci, G, Ibarrola, N, Iconomidou-Fayard, L, Ilyina-Brunner, K, Incandela, J, Infantino, A, Ippolito, V, Ishino, M, Islam, R, Ita, H, Ivanovs, A, Iwamoto, S, Iyer, A, Izquierdo Bermudez, S, Jadach, S, Jamin, D, Janot, P, Jarry, P, Jeff, A, Jenny, P, Jensen, E, Jensen, M, Jiang, X, Jimenez, J, Jones, M, Jones, O, Jowett, J, Jung, S, Kaabi, W, Kado, M, Kahle, K, Kalinovskaya, L, Kalinowski, J, Kamenik, J, Kannike, K, Kara, S, Karadeniz, H, Karaventzas, V, Karpov, I, Kartal, S, Karyukhin, A, Kashikhin, V, Katharina Behr, J, Kaya, U, Keintzel, J, Keinz, P, Keppel, K, Kersevan, R, Kershaw, K, Khanpour, H, Khatibi, S, Khatiri Yanehsari, M, Khoze, V, Kieseler, J, Kilic, A, Kilpinen, A, Kim, Y, Kim, D, Klein, U, Klein, M, Kling, F, Klinkenberg, N, Kloppel, S, Klute, M, Klyukhin, V, Knecht, M, Kniehl, B, Kocak, F, Koeberl, C, Kolano, A, Kollegger, A, Kolodziej, K, Kolomiets, A, Komppula, J, Koop, I, Koppenburg, P, Koratzinos, M, Kordiaczynska, M, Korjik, M, Kortner, O, Kostka, P, Kotlarski, W, Kotnig, C, Kottig, T, Kotwal, A, Kovalenko, A, Kowalski, S, Kozaczuk, J, Kozlov, G, Kozub, S, Krainer, A, Kramer, T, Kramer, M, Krammer, M, Krasnov, A, Krauss, F, Kravalis, K, Kretzschmar, L, Kriske, R, Kritscher, H, Krkotic, P, Kroha, H, Kucharczyk, M, Kuday, S, Kuendig, A, Kuhlmann, G, Kulesza, A, Kumar, M, Kusina, A, Kuttimalai, S, Kuze, M, Kwon, T, Lackner, F, Lackner, M, La Francesca, E, Laine, M, Lamanna, G, La Mendola, S, Lancon, E, Landsberg, G, Langacker, P, Lange, C, Langner, A, Lankford, A, Lansberg, J, Lari, T, Laycock, P, Lebrun, P, Lechner, A, Lee, K, Lee, S, Lee, R, Lefevre, T, Le Guen, P, Lehtinen, T, Leith, S, Lenzi, P, Leogrande, E, Leonidopoulos, C, Leon-Monzon, I, Lerner, G, Leroy, O, Lesiak, T, Levai, P, Leveratto, A, Levichev, E, Li, G, Li, S, Li, R, Liberati, D, Liepe, M, Lissauer, D, Liu, Z, Lobko, A, Locci, E, Logothetis Agaliotis, E, Lombardo, M, Long, A, Lorin, C, Losito, R, Louzguiti, A, Low, I, Lucchesi, D, Lucchini, M, Luciani, A, Lueckhof, M, Lunt, A, Luzum, M, Lyubimtsev, D, Maggiora, M, Magnin, N, Mahmoud, M, Mahmoudi, F, Maitre, J, Makarenko, V, Malagoli, A, Malcles, J, Malgeri, L, Mallon, P, Maltoni, F, Malvezzi, S, Malyshev, O, Mancinelli, G, Mandrik, P, Manfrinetti, P, Mangano, M, Manil, P, Mannelli, M, Marchiori, G, Marhauser, F, Mariani, V, Marinozzi, V, Mariotto, S, Marquard, P, Marquet, C, Marriott-Dodington, T, Martin, R, Martin, O, Martin Camalich, J, Martinez, T, Martinez Bruzual, H, Martinez-Hernandez, M, Martins, D, Marzani, S, Marzocca, D, Marzola, L, Masciocchi, S, Masina, I, Massimiliano, A, Massironi, A, Masubuchi, T, Matveev, V, Mazzoni, M, Mccullough, M, Mcintosh, P, Meade, P, Medina, L, Meier, A, Meignan, J, Mele, B, Mendes Saraiva, J, Menez, F, Mentink, M, Meoni, E, Meridiani, P, Merk, M, Mermod, P, Mertens, V, Mether, L, Metral, E, Migliorati, M, Milanese, A, Milardi, C, Milhano, G, Militsyn, B, Millet, F, Minashvili, I, Minervini, J, Miralles, L, Mirarchi, D, Mishima, S, Missiaen, D, Mitselmakher, G, Mitshuhashi, T, Mnich, J, Mohammadi Najafabadi, M, Mohapatra, R, Mokhov, N, Molson, J, Monge, R, Montag, C, Montagna, G, Monteil, S, Montenero, G, Montesinos, E, Moortgat, F, Morange, N, Morello, G, Moreno Llacer, M, Moretti, M, Moretti, S, Morley, A, Moros, A, Morozov, I, Morretta, V, Morrone, M, Mostacci, A, Muanza, S, Muchnoi, N, Muhlegger, M, Mulder, M, Mulders, M, Muller, B, Muller, F, Muller, A, Munilla, J, Murray, M, Muttoni, Y, Myers, S, Mylona, M, Nachtman, J, Nakamoto, T, Nardecchia, M, Nardini, G, Nason, P, Nergiz, Z, Nesterenko, A, Netto, J, Nettstrater, A, Neubuser, C, Neundorf, J, Niccoli, F, Nicrosini, O, Nie, Y, Niedermayer, U, Niedziela, J, Niemi, A, Nikitin, S, Nisati, A, No, J, Nonis, M, Nosochkov, Y, Novak, M, Novokhatski, A, O'Callaghan, J, Ochando, C, Ogur, S, Ohmi, K, Oide, K, Okorokov, V, Okumura, Y, Oleari, C, Olness, F, Onel, Y, Ortino, M, Osborne, J, Osland, P, Otto, T, Oyulmaz, K, Ozansoy, A, Ozcan, V, Ozdemir, K, Pagliarone, C, Pais da Silva, H, Palmieri, E, Palumbo, L, Pampaloni, A, Pan, R, Panareo, M, Panella, O, Panico, G, Panizzo, G, Pankov, A, Pantsyrny, V, Papadopoulos, C, Papaefstathiou, A, Papaphilippou, Y, Parker, M, Parma, V, Pasquali, M, Patra, S, Patterson, R, Paukkunen, H, Pauss, F, Peggs, S, Penttinen, J, Peon, G, Perepelkin, E, Perez, E, Perez, J, Perez, G, Perez, F, Perez Codina, E, Perez Morales, J, Perfilov, M, Pernegger, H, Peruzzi, M, Pes, C, Peters, K, Petracca, S, Petriello, F, Pezzotti, L, Pfeiffer, S, Piccinini, F, Pieloni, T, Pierini, M, Pikhartova, H, Pikurs, G, Pilicer, E, Piminov, P, Pira, C, Pittau, R, Placzek, W, Plagge, M, Plehn, T, Pleier, M, Ploskon, M, Podeur, M, Podlech, H, Podzorny, T, Poggioli, L, Poiron, A, Polesello, G, Poli Lener, M, Polini, A, Polinski, J, Polozov, S, Ponce, L, Pont, M, Pontecorvo, L, Portaluri, T, Potamianos, K, Prasse, C, Prausa, M, Preinerstorfer, A, Premat, E, Price, T, Primavera, M, Prino, F, Prioli, M, Proudfoot, J, Provino, A, Pugnat, T, Pukhaeva, N, Pulawski, S, Pulikowski, D, Punzi, G, Putti, M, Pyarelal, A, Quack, H, Quispe, M, Racioppi, A, Rafique, H, Raginel, V, Raidal, M, Ramirez-Uribe, N, Ramsey-Musolf, M, Rata, R, Ratoff, P, Ravotti, F, Rebello Teles, P, Reboud, M, Redaelli, S, Renner, E, Renteria-Olivo, A, Rescigno, M, Reuter, J, Ribon, A, Ricci, A, Riegler, W, Riemann, S, Riemann, B, Riemann, T, Rifflet, J, Rimmer, R, Rinaldesi, R, Rinolfi, L, Rios Rubiras, O, Risselada, T, Rivetti, A, Rivkin, L, Rizzo, T, Robens, T, Robert, F, Robson, A, Rochepault, E, Roda, C, Rodrigo, G, Rodriguez-Cahuantzi, M, Rogan, C, Roig, M, Rojas-Torres, S, Rojo, J, Rolandi, G, Rolando, G, Roloff, P, Romanenko, A, Romanov, A, Roncarolo, F, Rosado Sanchez, A, Rosaz, G, Rossi, L, Rossi, A, Rossmanith, R, Rousset, B, Royon, C, Ruan, X, Ruehl, I, Ruhlmann-Kleider, V, Ruiz, R, Rumyantsev, L, Ruprecht, R, Ryazanov, A, Saba, A, Sadykov, R, Saez de Jauregui, D, Sahin, M, Sailer, B, Saito, M, Sala, F, Salam, G, Salfeld-Nebgen, J, Salgado, C, Salini, S, Sallese, J, Salmi, T, Salzburger, A, Sampayo, O, Sanfilippo, S, Santiago, J, Santopinto, E, Santoro, R, Sanz Ull, A, Sarasola, X, Sarpun, I, Sauvain, M, Savelyeva, S, Sawada, R, Sborlini, G, Schaffer, A, Schaumann, M, Schenk, M, Scheuerlein, C, Schienbein, I, Schlenga, K, Schmickler, H, Schmidt, R, Schoerling, D, Schoning, A, Schorner-Sadenius, T, Schott, M, Schulte, D, Schwaller, P, Schwanenberger, C, Schwemling, P, Schwerg, N, Scibile, L, Sciuto, A, Scomparin, E, Sebastiani, C, Seeber, B, Segreti, M, Selva, P, Selvaggi, M, Senatore, C, Senol, A, Serin, L, Serluca, M, Serra, N, Seryi, A, Sestini, L, Sfyrla, A, Shaposhnikov, M, Shaposhnikova, E, Sharkov, B, Shatilov, D, Shelton, J, Shiltsev, V, Shipsey, I, Shirkov, G, Shivaji, A, Shwartz, D, Sian, T, Sidorov, S, Siemko, A, Silvestrini, L, Simand, N, Simon, F, Singh, B, Siodmok, A, Sirois, Y, Sirtori, E, Sirvinskaite, R, Sitar, B, Sjostrand, T, Skands, P, Skordis, E, Skovpen, K, Skrzypek, M, Slade, E, Slavich, P, Slovak, R, Smaluk, V, Smirnov, V, Snoeys, W, Soffi, L, Sollander, P, Solovyanov, O, Soltveit, H, Song, H, Sopicki, P, Sorbi, M, Spallino, L, Spannowsky, M, Spataro, B, Sphicas, P, Spiesberger, H, Spiller, P, Spira, M, Srivastava, T, Stachel, J, Stakia, A, Stanyard, J, Starchenko, E, Starikov, A, Stasto, A, Statera, M, Steerenberg, R, Steggemann, J, Stenvall, A, Stivanello, F, Stockinger, D, Stoel, L, Stoger-Pollach, M, Strauss, B, Stuart, M, Stupakov, G, Su, S, Sublet, A, Sugita, K, Sulak, L, Sullivan, M, Sultansoy, S, Sumida, T, Suzuki, K, Sylva, G, Syphers, M, Sznajder, A, Taborelli, M, Tahir, N, Takeuchi, M, Tal Hod, E, Tambasco, C, Tanaka, J, Tang, K, Tapan, I, Taroni, S, Tartarelli, G, Tassielli, G, Tavian, L, Taylor, T, Taylor, G, Teixeira, A, Tejeda-Munoz, G, Telnov, V, Tenchini, R, ten Kate, H, Terashi, K, Tesi, A, Testa, M, Tetrel, C, Teytelman, D, Thaler, J, Thamm, A, Thomas, S, Tiirakari, M, Tikhomirov, V, Tikhonov, D, Timko, H, Tisserand, V, Tkachenko, L, Tkaczuk, J, Tock, J, Todd, B, Todesco, E, Tomas Garcia, R, Tommasini, D, Tonelli, G, Toral, F, Torims, T, Torre, R, Townsend, Z, Trant, R, Treille, D, Trentadue, L, Tricoli, A, Tricomi, A, Trischuk, W, Tropin, I, Tuchming, B, Tudora, A, Turbiarz, B, Turk Cakir, I, Turri, M, Tydecks, T, Usovitsch, J, Uythoven, J, Vaglio, R, Valassi, A, Valchkova, F, Valdivia Garcia, M, Valente, P, Valente, R, Valente-Feliciano, A, Valentino, G, Vale Silva, L, Valet, J, Valizadeh, R, Valle, J, Vallecorsa, S, Vallone, G, van Leeuwen, M, van Rienen, U, van Riesen-Haupt, L, Varasteh, M, Vecchi, L, Vedrine, P, Velev, G, Veness, R, Ventura, A, Venturini Delsolaro, W, Verducci, M, Verhaaren, C, Vernieri, C, Verweij, A, Verwilligen, O, Viazlo, O, Vicini, A, Viehhauser, G, Vignaroli, N, Vignolo, M, Vitrano, A, Vivarelli, I, Vlachos, S, Vogel, M, Vogt, D, Volkl, V, Volkov, P, Volpini, G, von Ahnen, J, Vorotnikov, G, Voutsinas, G, Vysotsky, V, Wagner, U, Wallny, R, Wang, L, Wang, R, Wang, K, Ward, B, Watson, T, Watson, N, Ws, Z, Weiland, C, Weinzierl, S, Welsch, C, Wenninger, J, Widorski, M, Wiedemann, U, Wienands, H, Wilkinson, G, Williams, P, Winter, A, Wohlfahrt, A, Wojton, T, Wollmann, D, Womersley, J, Woog, D, Wu, X, Wulzer, A, Yanehsari, M, Yang, G, Yang, H, Yao, W, Yazgan, E, Yermolchik, V, Yilmaz, A, Yoo, H, Yost, S, You, T, Young, C, Yu, T, Yu, F, Zaborowska, A, Zadeh, S, Zahnd, M, Zanetti, M, Zanotto, L, Zawiejski, L, Zeiler, P, Zerlauth, M, Zernov, S, Zevi Dell Porta, G, Zhang, Z, Zhang, Y, Zhang, C, Zhang, H, Zhao, Z, Zhong, Y, Zhou, J, Zhou, D, Zhuang, P, Zick, G, Zimmermann, F, Zinn-Justin, J, Zivkovic, L, Zlobin, A, Zobov, M, Zupan, J, Zurita, J, Abada A., Abbrescia M., AbdusSalam S. S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A. O., Adzic P. R., Agrawal P., Aguilar-Saavedra J. A., Aguilera-Verdugo J. J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J. L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R. M., Alexahin Y., Alia R. G., Alioli S., Alipour Tehrani N., Allanach B. C., Allport P. P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S. A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R. B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S. A., Arzeo M., Asai S., Aslanides E., Assmann R. W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y. W., Baglin V., Bai Y., Baird S., Baker M. J., Baldwin M. J., Ball A. H., Ballarino A., Banerjee S., Barber D. P., Barducci D., Barjhoux P., Barna D., Barnafoldi G. G., Barnes M. J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S. A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J. M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M. I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M. E., Biarrotte J. -L., Bibet Chevalier A., Bielert E. R., Biglietti M., Bilei G. M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O. R., Blanquez F. R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S. A., Bogomyagkov A., Boine-Frankenheim O., Boland M. J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R. R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J. A., Britzger D., Brodsky S. J., Brooke J. J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J. -P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J. M., Camarri P., Campanelli M., Camporesi T., Canbay A. C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C. M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T. K., Chattopadhyay S., Chehab R., Chekanov S. V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J. T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A. K., Ciftci R., Cimino R., Ciuchini M., Clark P. J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C. T. A., Cooley L., Corcella G., Cornell A. S., Corral G. H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J. F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R. T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S. P., DasBakshi S., da Silva W., da Silveira G. G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C. J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S. J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P. S. B., de Vivie de Regie J. B., Dewanjee R. K., Di Ciaccio A., Di Cicco A., Dillon B. M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J. M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S. A., Ellis J., Ellison J. A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K. J., Esposito L. S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D. A., Fartoukh S. D., Faus-Golfe A., Fawcett W. J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A. M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S. V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M. V., Garzia I., Gascon-Shotkin S. M., Gaudio G., Gay P., Ge S. -F., Gehrmann T., Genest M. H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S. S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G. F., Giunta A., Gladilin L. K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V. P., Goncalo R., Gonzalez Gomez L. A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S. A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H. M., Greco M., Grenard J. -L., Grimm O., Grojean C., Gromov V. A., Grosse-Oetringhaus J. F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y. O., Gupta R., Gupta R. S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P. C., Hati C., Haug S., Hauptman J., Haurylavets V., He H. -J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R. J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D. K., Honorato C. G., Hopkins S. C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D. O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J. M., Jones M. A., Jones O. R., Jowett J. M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J. F., Kannike K., Kara S. O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P. A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V. V., Kieseler J., Kilic A., Kilpinen A., Kim Y. -K., Kim D. W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V. I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A. M., Kollegger A., Kolodziej K., Kolomiets A. A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A. V., Kovalenko A. D., Kowalski S., Kozaczuk J., Kozlov G. A., Kozub S. S., Krainer A. M., Kramer T., Kramer M., Krammer M., Krasnov A. A., Krauss F., Kravalis K., Kretzschmar L., Kriske R. M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A. J., Lansberg J. P., Lari T., Laycock P. J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S. B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D. A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M. P., Long A. J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M. T., Luciani A., Lueckhof M., Lunt A. J. G., Luzum M., Lyubimtsev D. A., Maggiora M., Magnin N., Mahmoud M. A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P. J., Maltoni F., Malvezzi S., Malyshev O. B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M. I., Martins D. E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V. A., Mazzoni M. A., McCullough M., McIntosh P. A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J. G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B. L., Millet F., Minashvili I., Minervini J. V., Miralles L. S., Mirarchi D., Mishima S., Missiaen D. P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R. N., Mokhov N., Molson J. G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A. K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A. -S., Munilla J., Murray M. J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A. V., Netto J. A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S. A., Nisati A., No J. M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J. M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V. A., Okumura Y., Oleari C., Olness F. I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K. Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C. E., Pais da Silva H. F., Palmieri E., Palumbo L., Pampaloni A., Pan R. -Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A. A., Pantsyrny V., Papadopoulos C. G., Papaefstathiou A., Papaphilippou Y., Parker M. A., Parma V., Pasquali M., Patra S. K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J. -P., Peon G., Perepelkin E. E., Perez E., Perez J. C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M. -A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S. M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N. S., Ramsey-Musolf M. J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A. E., Rescigno M., Reuter J., Ribon A., Ricci A. M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J. M., Rimmer R. A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A. J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A. I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G. P., Salfeld-Nebgen J., Salgado C. A., Salini S., Sallese J. M., Salmi T., Salzburger A., Sampayo O. A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I. H., Sauvain M., Savelyeva S., Sawada R., Sborlini G. F. R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B. Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I. P., Shirkov G. D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B. K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H. K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J. L., Starchenko E., Starikov A. Y., Stasto A. M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L. S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M. K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M. J., Sznajder A., Taborelli M., Tahir N. A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G. F., Tassielli G., Tavian L., Taylor T. M., Taylor G. N., Teixeira A. M., Tejeda-Munoz G., Telnov V. I., Tenchini R., ten Kate H. H. J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M. T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L. M., Tkaczuk J., Tock J. P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I. S., Tuchming B., Tudora A. A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M. A., Valente P., Valente R. U., Valente-Feliciano A. -M., Valentino G., Vale Silva L., Valet J. M., Valizadeh R., Valle J. W. F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U. H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C. B., Vernieri C., Verweij A. P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D. M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G. G., Vysotsky V., Wagner U., Wallny R., Wang L. -T., Wang R., Wang K., Ward B. F. L., Watson T. P., Watson N. K., Ws Z., Weiland C., Weinzierl S., Welsch C. P., Wenninger J., Widorski M., Wiedemann U. A., Wienands H. -U., Wilkinson G., Williams P. H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M. K., Yang G., Yang H. J., Yao W. -M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H. -D., Yost S. A., You T., Young C., Yu T. -T., Yu F., Zaborowska A., Zadeh S. G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S. M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y. -M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A. V., Zobov M., Zupan J., Zurita J., Abada, A, Abbrescia, M, Abdussalam, S, Abdyukhanov, I, Abelleira Fernandez, J, Abramov, A, Aburaia, M, Acar, A, Adzic, P, Agrawal, P, Aguilar-Saavedra, J, Aguilera-Verdugo, J, Aiba, M, Aichinger, I, Aielli, G, Akay, A, Akhundov, A, Aksakal, H, Albacete, J, Albergo, S, Alekou, A, Aleksa, M, Aleksan, R, Alemany Fernandez, R, Alexahin, Y, Alia, R, Alioli, S, Alipour Tehrani, N, Allanach, B, Allport, P, Altinli, M, Altmannshofer, W, Ambrosio, G, Amorim, D, Amstutz, O, Anderlini, L, Andreazza, A, Andreini, M, Andriatis, A, Andris, C, Andronic, A, Angelucci, M, Antinori, F, Antipov, S, Antonelli, M, Antonello, M, Antonioli, P, Antusch, S, Anulli, F, Apolinario, L, Apollinari, G, Apollonio, A, Appelo, D, Appleby, R, Apyan, A, Arbey, A, Arbuzov, A, Arduini, G, Ari, V, Arias, S, Armesto, N, Arnaldi, R, Arsenyev, S, Arzeo, M, Asai, S, Aslanides, E, Assmann, R, Astapovych, D, Atanasov, M, Atieh, S, Attie, D, Auchmann, B, Audurier, A, Aull, S, Aumon, S, Aune, S, Avino, F, Avrillaud, G, Aydin, G, Azatov, A, Azuelos, G, Azzi, P, Azzolini, O, Azzurri, P, Bacchetta, N, Bacchiocchi, E, Bachacou, H, Baek, Y, Baglin, V, Bai, Y, Baird, S, Baker, M, Baldwin, M, Ball, A, Ballarino, A, Banerjee, S, Barber, D, Barducci, D, Barjhoux, P, Barna, D, Barnafoldi, G, Barnes, M, Barr, A, Barranco Garcia, J, Barreiro Guimaraes da Costa, J, Bartmann, W, Baryshevsky, V, Barzi, E, Bass, S, Bastianin, A, Baudouy, B, Bauer, F, Bauer, M, Baumgartner, T, Bautista-Guzman, I, Bayindir, C, Beaudette, F, Bedeschi, F, Beguin, M, Bellafont, I, Bellagamba, L, Bellegarde, N, Belli, E, Bellingeri, E, Bellini, F, Bellomo, G, Belomestnykh, S, Bencivenni, G, Benedikt, M, Bernardi, G, Bernardi, J, Bernet, C, Bernhardt, J, Bernini, C, Berriaud, C, Bertarelli, A, Bertolucci, S, Besana, M, Besancon, M, Beznosov, O, Bhat, P, Bhat, C, Biagini, M, Biarrotte, J, Bibet Chevalier, A, Bielert, E, Biglietti, M, Bilei, G, Bilki, B, Biscari, C, Bishara, F, Blanco-Garcia, O, Blanquez, F, Blekman, F, Blondel, A, Blumlein, J, Boccali, T, Boels, R, Bogacz, S, Bogomyagkov, A, Boine-Frankenheim, O, Boland, M, Bologna, S, Bolukbasi, O, Bomben, M, Bondarenko, S, Bonvini, M, Boos, E, Bordini, B, Bordry, F, Borghello, G, Borgonovi, L, Borowka, S, Bortoletto, D, Boscherini, D, Boscolo, M, Boselli, S, Bosley, R, Bossu, F, Botta, C, Bottura, L, Boughezal, R, Boutin, D, Bovone, G, Bozovic Jelisavic, I, Bozbey, A, Bozzi, C, Bozzini, D, Braccini, V, Braibant-Giacomelli, S, Bramante, J, Braun-Munzinger, P, Briffa, J, Britzger, D, Brodsky, S, Brooke, J, Bruce, R, Bruckman De Renstrom, P, Bruna, E, Bruning, O, Brunner, O, Brunner, K, Bruzzone, P, Buffat, X, Bulyak, E, Burkart, F, Burkhardt, H, Burnet, J, Butin, F, Buttazzo, D, Butterworth, A, Caccia, M, Cai, Y, Caiffi, B, Cairo, V, Cakir, O, Calaga, R, Calatroni, S, Calderini, G, Calderola, G, Caliskan, A, Calvet, D, Calviani, M, Camalich, J, Camarri, P, Campanelli, M, Camporesi, T, Canbay, A, Canepa, A, Cantergiani, E, Cantore-Cavalli, D, Capeans, M, Cardarelli, R, Cardella, U, Cardini, A, Carloni Calame, C, Carra, F, Carra, S, Carvalho, A, Casalbuoni, S, Casas, J, Cascella, M, Castelnovo, P, Castorina, G, Catalano, G, Cavasinni, V, Cazzato, E, Cennini, E, Cerri, A, Cerutti, F, Cervantes, J, Chaikovska, I, Chakrabortty, J, Chala, M, Chamizo-Llatas, M, Chanal, H, Chanal, D, Chance, S, Chance, A, Charitos, P, Charles, J, Charles, T, Chattopadhyay, S, Chehab, R, Chekanov, S, Chen, N, Chernoded, A, Chetvertkova, V, Chevalier, L, Chiarelli, G, Chiarello, G, Chiesa, M, Chiggiato, P, Childers, J, Chmielinska, A, Cholakian, A, Chomaz, P, Chorowski, M, Chou, W, Chrzaszcz, M, Chyhyrynets, E, Cibinetto, G, Ciftci, A, Ciftci, R, Cimino, R, Ciuchini, M, Clark, P, Coadou, Y, Cobal, M, Coccaro, A, Cogan, J, Cogneras, E, Collamati, F, Colldelram, C, Collier, P, Collot, J, Contino, R, Conventi, F, Cook, C, Cooley, L, Corcella, G, Cornell, A, Corral, G, Correia-Rodrigues, H, Costanza, F, Costa Pinto, P, Couderc, F, Coupard, J, Craig, N, Crespo Garrido, I, Crivellin, A, Croteau, J, Crouch, M, Cruz Alaniz, E, Cure, B, Curti, J, Curtin, D, Czech, M, Dachauer, C, D'Agnolo, R, Daibo, M, Dainese, A, Dalena, B, Daljevec, A, Dallapiazza, W, D'Aloia Schwartzentruber, L, Dam, M, D'Ambrosio, G, Das, S, Dasbakshi, S, da Silva, W, da Silveira, G, D'Auria, V, D'Auria, S, David, A, Davidek, T, Deandrea, A, de Blas, J, Debono, C, De Curtis, S, De Filippis, N, de Florian, D, Deghaye, S, de Jong, S, Del Bo, C, Del Duca, V, Delikaris, D, Deliot, F, Dell'Acqua, A, Delle Rose, L, Delmastro, M, De Lucia, E, Demarteau, M, Denegri, D, Deniau, L, Denisov, D, Denizli, H, Denner, A, D'Enterria, D, de Rijk, G, De Roeck, A, Derue, F, Deschamps, O, Descotes-Genon, S, Dev, P, de Vivie de Regie, J, Dewanjee, R, Di Ciaccio, A, Di Cicco, A, Dillon, B, Di Micco, B, Di Nezza, P, Di Vita, S, Doblhammer, A, Dominjon, A, D'Onofrio, M, Dordei, F, Drago, A, Draper, P, Drasal, Z, Drewes, M, Duarte, L, Dubovyk, I, Duda, P, Dudarev, A, Dudko, L, Duellmann, D, Dunser, M, du Pree, T, Durante, M, Duran Yildiz, H, Dutta, S, Duval, F, Duval, J, Dydyshka, Y, Dziewit, B, Eisenhardt, S, Eisterer, M, Ekelof, T, El Khechen, D, Ellis, S, Ellis, J, Ellison, J, Elsener, K, Elsing, M, Enari, Y, Englert, C, Eriksson, H, Eskola, K, Esposito, L, Etisken, O, Etzion, E, Fabbricatore, P, Falkowski, A, Falou, A, Faltova, J, Fan, J, Fano, L, Farilla, A, Farinelli, R, Farinon, S, Faroughy, D, Fartoukh, S, Faus-Golfe, A, Fawcett, W, Felici, G, Felsberger, L, Ferdeghini, C, Fernandez Navarro, A, Fernandez-Tellez, A, Ferradas Troitino, J, Ferrara, G, Ferrari, R, Ferreira, L, Ferreira da Silva, P, Ferrera, G, Ferro, F, Fiascaris, M, Fiorendi, S, Fiorio, C, Fischer, O, Fischer, E, Flieger, W, Florio, M, Fonnesu, D, Fontanesi, E, Foppiani, N, Foraz, K, Forkel-Wirth, D, Forte, S, Fouaidy, M, Fournier, D, Fowler, T, Fox, J, Francavilla, P, Franceschini, R, Franchino, S, Franco, E, Freitas, A, Fuks, B, Furukawa, K, Furuseth, S, Gabrielli, E, Gaddi, A, Galanti, M, Gallo, E, Ganjour, S, Gao, J, Garcia Diaz, V, Garcia Perez, M, Garcia Tabares, L, Garion, C, Garzelli, M, Garzia, I, Gascon-Shotkin, S, Gaudio, G, Gay, P, Ge, S, Gehrmann, T, Genest, M, Gerard, R, Gerigk, F, Gerwig, H, Giacomelli, P, Giagu, S, Gianfelice-Wendt, E, Gianotti, F, Giffoni, F, Gilardoni, S, Gil Costa, M, Giovannetti, M, Giovannozzi, M, Giubellino, P, Giudice, G, Giunta, A, Gladilin, L, Glukhov, S, Gluza, J, Gobbi, G, Goddard, B, Goertz, F, Golling, T, Goncalves, V, Goncalo, R, Gonzalez Gomez, L, Gorgi Zadeh, S, Gorine, G, Gorini, E, Gourlay, S, Gouskos, L, Grancagnolo, F, Grassellino, A, Grau, A, Graverini, E, Gray, H, Greco, M, Grenard, J, Grimm, O, Grojean, C, Gromov, V, Grosse-Oetringhaus, J, Grudiev, A, Grzanka, K, Gu, J, Guadagnoli, D, Guidi, V, Guiducci, S, Guillermo Canton, G, Gunaydin, Y, Gupta, R, Gutierrez, J, Gutleber, J, Guyot, C, Guzey, V, Gwenlan, C, Haberstroh, C, Hacisahinoglu, B, Haerer, B, Hahn, K, Hahn, T, Hammad, A, Han, C, Hance, M, Hannah, A, Harris, P, Hati, C, Haug, S, Hauptman, J, Haurylavets, V, He, H, Hegglin, A, Hegner, B, Heinemann, K, Heinemeyer, S, Helsens, C, Henriques, A, Hernandez, P, Hernandez-Pinto, R, Hernandez-Sanchez, J, Herzig, T, Hiekkanen, I, Hillert, W, Hoehn, T, Hofer, M, Hofle, W, Holdener, F, Holleis, S, Holzer, B, Hong, D, Honorato, C, Hopkins, S, Hrdinka, J, Hug, F, Humann, B, Humer, H, Hurth, T, Hutton, A, Iacobucci, G, Ibarrola, N, Iconomidou-Fayard, L, Ilyina-Brunner, K, Incandela, J, Infantino, A, Ippolito, V, Ishino, M, Islam, R, Ita, H, Ivanovs, A, Iwamoto, S, Iyer, A, Izquierdo Bermudez, S, Jadach, S, Jamin, D, Janot, P, Jarry, P, Jeff, A, Jenny, P, Jensen, E, Jensen, M, Jiang, X, Jimenez, J, Jones, M, Jones, O, Jowett, J, Jung, S, Kaabi, W, Kado, M, Kahle, K, Kalinovskaya, L, Kalinowski, J, Kamenik, J, Kannike, K, Kara, S, Karadeniz, H, Karaventzas, V, Karpov, I, Kartal, S, Karyukhin, A, Kashikhin, V, Katharina Behr, J, Kaya, U, Keintzel, J, Keinz, P, Keppel, K, Kersevan, R, Kershaw, K, Khanpour, H, Khatibi, S, Khatiri Yanehsari, M, Khoze, V, Kieseler, J, Kilic, A, Kilpinen, A, Kim, Y, Kim, D, Klein, U, Klein, M, Kling, F, Klinkenberg, N, Kloppel, S, Klute, M, Klyukhin, V, Knecht, M, Kniehl, B, Kocak, F, Koeberl, C, Kolano, A, Kollegger, A, Kolodziej, K, Kolomiets, A, Komppula, J, Koop, I, Koppenburg, P, Koratzinos, M, Kordiaczynska, M, Korjik, M, Kortner, O, Kostka, P, Kotlarski, W, Kotnig, C, Kottig, T, Kotwal, A, Kovalenko, A, Kowalski, S, Kozaczuk, J, Kozlov, G, Kozub, S, Krainer, A, Kramer, T, Kramer, M, Krammer, M, Krasnov, A, Krauss, F, Kravalis, K, Kretzschmar, L, Kriske, R, Kritscher, H, Krkotic, P, Kroha, H, Kucharczyk, M, Kuday, S, Kuendig, A, Kuhlmann, G, Kulesza, A, Kumar, M, Kusina, A, Kuttimalai, S, Kuze, M, Kwon, T, Lackner, F, Lackner, M, La Francesca, E, Laine, M, Lamanna, G, La Mendola, S, Lancon, E, Landsberg, G, Langacker, P, Lange, C, Langner, A, Lankford, A, Lansberg, J, Lari, T, Laycock, P, Lebrun, P, Lechner, A, Lee, K, Lee, S, Lee, R, Lefevre, T, Le Guen, P, Lehtinen, T, Leith, S, Lenzi, P, Leogrande, E, Leonidopoulos, C, Leon-Monzon, I, Lerner, G, Leroy, O, Lesiak, T, Levai, P, Leveratto, A, Levichev, E, Li, G, Li, S, Li, R, Liberati, D, Liepe, M, Lissauer, D, Liu, Z, Lobko, A, Locci, E, Logothetis Agaliotis, E, Lombardo, M, Long, A, Lorin, C, Losito, R, Louzguiti, A, Low, I, Lucchesi, D, Lucchini, M, Luciani, A, Lueckhof, M, Lunt, A, Luzum, M, Lyubimtsev, D, Maggiora, M, Magnin, N, Mahmoud, M, Mahmoudi, F, Maitre, J, Makarenko, V, Malagoli, A, Malcles, J, Malgeri, L, Mallon, P, Maltoni, F, Malvezzi, S, Malyshev, O, Mancinelli, G, Mandrik, P, Manfrinetti, P, Mangano, M, Manil, P, Mannelli, M, Marchiori, G, Marhauser, F, Mariani, V, Marinozzi, V, Mariotto, S, Marquard, P, Marquet, C, Marriott-Dodington, T, Martin, R, Martin, O, Martin Camalich, J, Martinez, T, Martinez Bruzual, H, Martinez-Hernandez, M, Martins, D, Marzani, S, Marzocca, D, Marzola, L, Masciocchi, S, Masina, I, Massimiliano, A, Massironi, A, Masubuchi, T, Matveev, V, Mazzoni, M, Mccullough, M, Mcintosh, P, Meade, P, Medina, L, Meier, A, Meignan, J, Mele, B, Mendes Saraiva, J, Menez, F, Mentink, M, Meoni, E, Meridiani, P, Merk, M, Mermod, P, Mertens, V, Mether, L, Metral, E, Migliorati, M, Milanese, A, Milardi, C, Milhano, G, Militsyn, B, Millet, F, Minashvili, I, Minervini, J, Miralles, L, Mirarchi, D, Mishima, S, Missiaen, D, Mitselmakher, G, Mitshuhashi, T, Mnich, J, Mohammadi Najafabadi, M, Mohapatra, R, Mokhov, N, Molson, J, Monge, R, Montag, C, Montagna, G, Monteil, S, Montenero, G, Montesinos, E, Moortgat, F, Morange, N, Morello, G, Moreno Llacer, M, Moretti, M, Moretti, S, Morley, A, Moros, A, Morozov, I, Morretta, V, Morrone, M, Mostacci, A, Muanza, S, Muchnoi, N, Muhlegger, M, Mulder, M, Mulders, M, Muller, B, Muller, F, Muller, A, Munilla, J, Murray, M, Muttoni, Y, Myers, S, Mylona, M, Nachtman, J, Nakamoto, T, Nardecchia, M, Nardini, G, Nason, P, Nergiz, Z, Nesterenko, A, Netto, J, Nettstrater, A, Neubuser, C, Neundorf, J, Niccoli, F, Nicrosini, O, Nie, Y, Niedermayer, U, Niedziela, J, Niemi, A, Nikitin, S, Nisati, A, No, J, Nonis, M, Nosochkov, Y, Novak, M, Novokhatski, A, O'Callaghan, J, Ochando, C, Ogur, S, Ohmi, K, Oide, K, Okorokov, V, Okumura, Y, Oleari, C, Olness, F, Onel, Y, Ortino, M, Osborne, J, Osland, P, Otto, T, Oyulmaz, K, Ozansoy, A, Ozcan, V, Ozdemir, K, Pagliarone, C, Pais da Silva, H, Palmieri, E, Palumbo, L, Pampaloni, A, Pan, R, Panareo, M, Panella, O, Panico, G, Panizzo, G, Pankov, A, Pantsyrny, V, Papadopoulos, C, Papaefstathiou, A, Papaphilippou, Y, Parker, M, Parma, V, Pasquali, M, Patra, S, Patterson, R, Paukkunen, H, Pauss, F, Peggs, S, Penttinen, J, Peon, G, Perepelkin, E, Perez, E, Perez, J, Perez, G, Perez, F, Perez Codina, E, Perez Morales, J, Perfilov, M, Pernegger, H, Peruzzi, M, Pes, C, Peters, K, Petracca, S, Petriello, F, Pezzotti, L, Pfeiffer, S, Piccinini, F, Pieloni, T, Pierini, M, Pikhartova, H, Pikurs, G, Pilicer, E, Piminov, P, Pira, C, Pittau, R, Placzek, W, Plagge, M, Plehn, T, Pleier, M, Ploskon, M, Podeur, M, Podlech, H, Podzorny, T, Poggioli, L, Poiron, A, Polesello, G, Poli Lener, M, Polini, A, Polinski, J, Polozov, S, Ponce, L, Pont, M, Pontecorvo, L, Portaluri, T, Potamianos, K, Prasse, C, Prausa, M, Preinerstorfer, A, Premat, E, Price, T, Primavera, M, Prino, F, Prioli, M, Proudfoot, J, Provino, A, Pugnat, T, Pukhaeva, N, Pulawski, S, Pulikowski, D, Punzi, G, Putti, M, Pyarelal, A, Quack, H, Quispe, M, Racioppi, A, Rafique, H, Raginel, V, Raidal, M, Ramirez-Uribe, N, Ramsey-Musolf, M, Rata, R, Ratoff, P, Ravotti, F, Rebello Teles, P, Reboud, M, Redaelli, S, Renner, E, Renteria-Olivo, A, Rescigno, M, Reuter, J, Ribon, A, Ricci, A, Riegler, W, Riemann, S, Riemann, B, Riemann, T, Rifflet, J, Rimmer, R, Rinaldesi, R, Rinolfi, L, Rios Rubiras, O, Risselada, T, Rivetti, A, Rivkin, L, Rizzo, T, Robens, T, Robert, F, Robson, A, Rochepault, E, Roda, C, Rodrigo, G, Rodriguez-Cahuantzi, M, Rogan, C, Roig, M, Rojas-Torres, S, Rojo, J, Rolandi, G, Rolando, G, Roloff, P, Romanenko, A, Romanov, A, Roncarolo, F, Rosado Sanchez, A, Rosaz, G, Rossi, L, Rossi, A, Rossmanith, R, Rousset, B, Royon, C, Ruan, X, Ruehl, I, Ruhlmann-Kleider, V, Ruiz, R, Rumyantsev, L, Ruprecht, R, Ryazanov, A, Saba, A, Sadykov, R, Saez de Jauregui, D, Sahin, M, Sailer, B, Saito, M, Sala, F, Salam, G, Salfeld-Nebgen, J, Salgado, C, Salini, S, Sallese, J, Salmi, T, Salzburger, A, Sampayo, O, Sanfilippo, S, Santiago, J, Santopinto, E, Santoro, R, Sanz Ull, A, Sarasola, X, Sarpun, I, Sauvain, M, Savelyeva, S, Sawada, R, Sborlini, G, Schaffer, A, Schaumann, M, Schenk, M, Scheuerlein, C, Schienbein, I, Schlenga, K, Schmickler, H, Schmidt, R, Schoerling, D, Schoning, A, Schorner-Sadenius, T, Schott, M, Schulte, D, Schwaller, P, Schwanenberger, C, Schwemling, P, Schwerg, N, Scibile, L, Sciuto, A, Scomparin, E, Sebastiani, C, Seeber, B, Segreti, M, Selva, P, Selvaggi, M, Senatore, C, Senol, A, Serin, L, Serluca, M, Serra, N, Seryi, A, Sestini, L, Sfyrla, A, Shaposhnikov, M, Shaposhnikova, E, Sharkov, B, Shatilov, D, Shelton, J, Shiltsev, V, Shipsey, I, Shirkov, G, Shivaji, A, Shwartz, D, Sian, T, Sidorov, S, Siemko, A, Silvestrini, L, Simand, N, Simon, F, Singh, B, Siodmok, A, Sirois, Y, Sirtori, E, Sirvinskaite, R, Sitar, B, Sjostrand, T, Skands, P, Skordis, E, Skovpen, K, Skrzypek, M, Slade, E, Slavich, P, Slovak, R, Smaluk, V, Smirnov, V, Snoeys, W, Soffi, L, Sollander, P, Solovyanov, O, Soltveit, H, Song, H, Sopicki, P, Sorbi, M, Spallino, L, Spannowsky, M, Spataro, B, Sphicas, P, Spiesberger, H, Spiller, P, Spira, M, Srivastava, T, Stachel, J, Stakia, A, Stanyard, J, Starchenko, E, Starikov, A, Stasto, A, Statera, M, Steerenberg, R, Steggemann, J, Stenvall, A, Stivanello, F, Stockinger, D, Stoel, L, Stoger-Pollach, M, Strauss, B, Stuart, M, Stupakov, G, Su, S, Sublet, A, Sugita, K, Sulak, L, Sullivan, M, Sultansoy, S, Sumida, T, Suzuki, K, Sylva, G, Syphers, M, Sznajder, A, Taborelli, M, Tahir, N, Takeuchi, M, Tal Hod, E, Tambasco, C, Tanaka, J, Tang, K, Tapan, I, Taroni, S, Tartarelli, G, Tassielli, G, Tavian, L, Taylor, T, Taylor, G, Teixeira, A, Tejeda-Munoz, G, Telnov, V, Tenchini, R, ten Kate, H, Terashi, K, Tesi, A, Testa, M, Tetrel, C, Teytelman, D, Thaler, J, Thamm, A, Thomas, S, Tiirakari, M, Tikhomirov, V, Tikhonov, D, Timko, H, Tisserand, V, Tkachenko, L, Tkaczuk, J, Tock, J, Todd, B, Todesco, E, Tomas Garcia, R, Tommasini, D, Tonelli, G, Toral, F, Torims, T, Torre, R, Townsend, Z, Trant, R, Treille, D, Trentadue, L, Tricoli, A, Tricomi, A, Trischuk, W, Tropin, I, Tuchming, B, Tudora, A, Turbiarz, B, Turk Cakir, I, Turri, M, Tydecks, T, Usovitsch, J, Uythoven, J, Vaglio, R, Valassi, A, Valchkova, F, Valdivia Garcia, M, Valente, P, Valente, R, Valente-Feliciano, A, Valentino, G, Vale Silva, L, Valet, J, Valizadeh, R, Valle, J, Vallecorsa, S, Vallone, G, van Leeuwen, M, van Rienen, U, van Riesen-Haupt, L, Varasteh, M, Vecchi, L, Vedrine, P, Velev, G, Veness, R, Ventura, A, Venturini Delsolaro, W, Verducci, M, Verhaaren, C, Vernieri, C, Verweij, A, Verwilligen, O, Viazlo, O, Vicini, A, Viehhauser, G, Vignaroli, N, Vignolo, M, Vitrano, A, Vivarelli, I, Vlachos, S, Vogel, M, Vogt, D, Volkl, V, Volkov, P, Volpini, G, von Ahnen, J, Vorotnikov, G, Voutsinas, G, Vysotsky, V, Wagner, U, Wallny, R, Wang, L, Wang, R, Wang, K, Ward, B, Watson, T, Watson, N, Ws, Z, Weiland, C, Weinzierl, S, Welsch, C, Wenninger, J, Widorski, M, Wiedemann, U, Wienands, H, Wilkinson, G, Williams, P, Winter, A, Wohlfahrt, A, Wojton, T, Wollmann, D, Womersley, J, Woog, D, Wu, X, Wulzer, A, Yanehsari, M, Yang, G, Yang, H, Yao, W, Yazgan, E, Yermolchik, V, Yilmaz, A, Yoo, H, Yost, S, You, T, Young, C, Yu, T, Yu, F, Zaborowska, A, Zadeh, S, Zahnd, M, Zanetti, M, Zanotto, L, Zawiejski, L, Zeiler, P, Zerlauth, M, Zernov, S, Zevi Dell Porta, G, Zhang, Z, Zhang, Y, Zhang, C, Zhang, H, Zhao, Z, Zhong, Y, Zhou, J, Zhou, D, Zhuang, P, Zick, G, Zimmermann, F, Zinn-Justin, J, Zivkovic, L, Zlobin, A, Zobov, M, Zupan, J, Zurita, J, Abada A., Abbrescia M., AbdusSalam S. S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A. O., Adzic P. R., Agrawal P., Aguilar-Saavedra J. A., Aguilera-Verdugo J. J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J. L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R. M., Alexahin Y., Alia R. G., Alioli S., Alipour Tehrani N., Allanach B. C., Allport P. P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S. A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R. B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S. A., Arzeo M., Asai S., Aslanides E., Assmann R. W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y. W., Baglin V., Bai Y., Baird S., Baker M. J., Baldwin M. J., Ball A. H., Ballarino A., Banerjee S., Barber D. P., Barducci D., Barjhoux P., Barna D., Barnafoldi G. G., Barnes M. J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S. A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J. M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M. I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M. E., Biarrotte J. -L., Bibet Chevalier A., Bielert E. R., Biglietti M., Bilei G. M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O. R., Blanquez F. R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S. A., Bogomyagkov A., Boine-Frankenheim O., Boland M. J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R. R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J. A., Britzger D., Brodsky S. J., Brooke J. J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J. -P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J. M., Camarri P., Campanelli M., Camporesi T., Canbay A. C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C. M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T. K., Chattopadhyay S., Chehab R., Chekanov S. V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J. T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A. K., Ciftci R., Cimino R., Ciuchini M., Clark P. J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C. T. A., Cooley L., Corcella G., Cornell A. S., Corral G. H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J. F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R. T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S. P., DasBakshi S., da Silva W., da Silveira G. G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C. J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S. J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P. S. B., de Vivie de Regie J. B., Dewanjee R. K., Di Ciaccio A., Di Cicco A., Dillon B. M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J. M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S. A., Ellis J., Ellison J. A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K. J., Esposito L. S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D. A., Fartoukh S. D., Faus-Golfe A., Fawcett W. J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A. M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S. V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M. V., Garzia I., Gascon-Shotkin S. M., Gaudio G., Gay P., Ge S. -F., Gehrmann T., Genest M. H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S. S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G. F., Giunta A., Gladilin L. K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V. P., Goncalo R., Gonzalez Gomez L. A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S. A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H. M., Greco M., Grenard J. -L., Grimm O., Grojean C., Gromov V. A., Grosse-Oetringhaus J. F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y. O., Gupta R., Gupta R. S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P. C., Hati C., Haug S., Hauptman J., Haurylavets V., He H. -J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R. J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D. K., Honorato C. G., Hopkins S. C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D. O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J. M., Jones M. A., Jones O. R., Jowett J. M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J. F., Kannike K., Kara S. O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P. A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V. V., Kieseler J., Kilic A., Kilpinen A., Kim Y. -K., Kim D. W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V. I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A. M., Kollegger A., Kolodziej K., Kolomiets A. A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A. V., Kovalenko A. D., Kowalski S., Kozaczuk J., Kozlov G. A., Kozub S. S., Krainer A. M., Kramer T., Kramer M., Krammer M., Krasnov A. A., Krauss F., Kravalis K., Kretzschmar L., Kriske R. M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A. J., Lansberg J. P., Lari T., Laycock P. J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S. B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D. A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M. P., Long A. J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M. T., Luciani A., Lueckhof M., Lunt A. J. G., Luzum M., Lyubimtsev D. A., Maggiora M., Magnin N., Mahmoud M. A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P. J., Maltoni F., Malvezzi S., Malyshev O. B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M. I., Martins D. E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V. A., Mazzoni M. A., McCullough M., McIntosh P. A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J. G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B. L., Millet F., Minashvili I., Minervini J. V., Miralles L. S., Mirarchi D., Mishima S., Missiaen D. P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R. N., Mokhov N., Molson J. G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A. K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A. -S., Munilla J., Murray M. J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A. V., Netto J. A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S. A., Nisati A., No J. M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J. M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V. A., Okumura Y., Oleari C., Olness F. I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K. Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C. E., Pais da Silva H. F., Palmieri E., Palumbo L., Pampaloni A., Pan R. -Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A. A., Pantsyrny V., Papadopoulos C. G., Papaefstathiou A., Papaphilippou Y., Parker M. A., Parma V., Pasquali M., Patra S. K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J. -P., Peon G., Perepelkin E. E., Perez E., Perez J. C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M. -A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S. M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N. S., Ramsey-Musolf M. J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A. E., Rescigno M., Reuter J., Ribon A., Ricci A. M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J. M., Rimmer R. A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A. J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A. I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G. P., Salfeld-Nebgen J., Salgado C. A., Salini S., Sallese J. M., Salmi T., Salzburger A., Sampayo O. A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I. H., Sauvain M., Savelyeva S., Sawada R., Sborlini G. F. R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B. Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I. P., Shirkov G. D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B. K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H. K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J. L., Starchenko E., Starikov A. Y., Stasto A. M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L. S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M. K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M. J., Sznajder A., Taborelli M., Tahir N. A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G. F., Tassielli G., Tavian L., Taylor T. M., Taylor G. N., Teixeira A. M., Tejeda-Munoz G., Telnov V. I., Tenchini R., ten Kate H. H. J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M. T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L. M., Tkaczuk J., Tock J. P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I. S., Tuchming B., Tudora A. A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M. A., Valente P., Valente R. U., Valente-Feliciano A. -M., Valentino G., Vale Silva L., Valet J. M., Valizadeh R., Valle J. W. F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U. H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C. B., Vernieri C., Verweij A. P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D. M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G. G., Vysotsky V., Wagner U., Wallny R., Wang L. -T., Wang R., Wang K., Ward B. F. L., Watson T. P., Watson N. K., Ws Z., Weiland C., Weinzierl S., Welsch C. P., Wenninger J., Widorski M., Wiedemann U. A., Wienands H. -U., Wilkinson G., Williams P. H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M. K., Yang G., Yang H. J., Yao W. -M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H. -D., Yost S. A., You T., Young C., Yu T. -T., Yu F., Zaborowska A., Zadeh S. G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S. M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y. -M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A. V., Zobov M., Zupan J., and Zurita J.
Abstract: In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.
Published: 2019

16. Study of the projected sensitivity on the anomalous quartic gauge couplings via $Z\gamma\gamma$ production at the CLIC

Author: Gurkanli, E., Ari, V., Köksal, M., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., Gurkanli, E., Ari, V., Köksal, M., Gutiérrez-Rodríguez, A., and Hernández-Ruíz, M. A.
Abstract: Gauge boson self-couplings are completely defined by the non-Abelian gauge symmetry of the Standard Model (SM), thus direct search for these couplings are extremely significant in understanding the gauge structure of the SM. The possible deviation from the SM predictions of gauge boson self-couplings would be a sign of the presence of new physics beyond the SM. In this work, we study the sensitivities on the anomalous couplings defined by dimension-8 operators related to the $ZZ\gamma\gamma$ and $Z\gamma\gamma\gamma$ quartic vertices through the process $e^+e^- \to Z\gamma\gamma$ with Z-boson decaying to charged leptons at the Compact Linear Collider (CLIC). We analyze the center-of-mass energy of 3 TeV, integrated luminosities of ${\cal L}=1, 4, 5$ $\rm ab^{-1}$, systematic uncertainties of $\delta_{sys}=0\%, 5\%, 10\%$, and unpolarized and polarized electron beams for extraction of expected sensitivity on the anomalous $f_ {T,j}/\Lambda^4$ couplings at $95\%$ confidence level, which are especially sensitive to the $Z\gamma\gamma$ channel. It is clear from the results that if the systematic error is improved, we expect better limits on the couplings. The best limits obtained on the anomalous quartic couplings for the process $e^+e^- \to Z\gamma\gamma$ with $\sqrt{s}= 3$ TeV, ${\cal L}=5$ $\rm ab^{-1}$ and $\delta_{sys}=0\%$ can be approximately improved up to about two times better than the limits obtained with $\delta_{sys}=10\%$. Our sensitivities on the anomalous quartic couplings with $\delta_{sys}=0\%$ can set more stringent sensitivity by two orders of magnitude concerning the best sensitivity derived from the current experimental limits. Finally, with initial electron beam polarization, the sensitivity of the anomalous quartic couplings improves by almost a factor of 1.2., Comment: 38 pages, 22 figures
Published: 2021

17. Studying Same-Sign Top Pair Production in Flavor Changing Scalar Models at the HL-LHC

Author: Ozsimsek, O. M., Ari, V., Cakir, O., Ozsimsek, O. M., Ari, V., and Cakir, O.
Abstract: We investigate the potential of the HL-LHC for discovering new physics effects via the same-sign top pair signatures. We focus on the semi leptonic (electron and muon) decay of the top quarks and study the reach for a simplified model approach where top quark flavor changing could occur through a neutral scalar exchange. A relatively smaller background contribution and clean signature are the advantages of the leptonic decay mode of the same-sign $W$ bosons in the same-sign production processes of top quark pairs. Assuming the FCNC between top quark, up type quark and scalar boson from the new physics interactions the branchings could be excluded of the order ${\cal O}(10^{-4})$. We use angular observables of the same-sign lepton pairs and the top quark kinematics in the process which provide the possibility of separation of new physics signal from the SM backgrounds using machine learning teqniques. We find that the same-sign top quark pair production is quite capable of testing the top-Higgs FCNCs at the HL-LHC., Comment: 10 pages, 20 figures
Published: 2021

18. Future projections on the anomalous $WW\gamma\gamma$ couplings in hadron-hadron interactions at the FCC-hh

Author: Gutiérrez-Rodríguez, A., Ari, V., Gurkanli, E., Köksal, M., Hernández-Ruíz, M. A., Gutiérrez-Rodríguez, A., Ari, V., Gurkanli, E., Köksal, M., and Hernández-Ruíz, M. A.
Abstract: We carry out a study in the approach of a dimension-8 effective field theory on the anomalous quartic $WW\gamma\gamma$ couplings that arise from the process $pp \to W\gamma\gamma$ at the Future Circular Collider-hadron hadron (FCC-hh). The process is sensitive to the $WW\gamma\gamma$ vertex, and future projections on the anomalous $f_ {M,i}/\Lambda^4$ and $ f_ {T,j}/\Lambda^4$ couplings can be put by measurements of $W\gamma\gamma$ production. We illustrate the physics opportunities and reach of the FCC-hh operating for a high integrated luminosity scenario of ${\cal L}=1, 5, 10, 30$ ${\rm ab}^{-1}$ of proton-proton collisions at a center-of-mass energy of $\sqrt{s}=100$ TeV and systematic uncertainties of $\delta_{sys}=0\%, 3\%, 5\%, 10\%$. Production cross-sections of the signal and the sensitivity constraints on the anomalous $f_ {M,i}/\Lambda^4$ and $ f_ {T,j}/\Lambda^4$ couplings at $95\%$ C.L. are identified through the leptonic and hadronic decay modes of the $W$-boson. The FCC-hh sensitivity on these anomalous couplings is expected might reach up to the order of magnitude ${\cal O}(10^{-4}-10^1)$. These sensitivity perspectives indicate that the $pp \to W\gamma\gamma$ channel at the FCC-hh has a greater potential to search for the anomalous quartic $WW\gamma\gamma$ couplings and to search for new physics than present colliders., Comment: 29 pages, 8 figures
Published: 2021
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19. The role of inflammatory cytokines as intermediates in the pathway from increased adiposity to disease

Author: Kalaoja, M. (Marita), Corbin, L. J. (Laura J.), Tan, V. Y. (Vanessa Y.), Ahola‐Olli, A. V. (Ari V.), Havulinna, A. S. (Aki S.), Santalahti, K. (Kristiina), Pitkänen, N. (Niina), Lehtimäki, T. (Terho), Lyytikäinen, L. (Leo‐Pekka), Raitoharju, E. (Emma), Seppälä, I. (Ilkka), Kähönen, M. (Mika), Ripatti, S. (Samuli), Palotie, A. (Aarno), Perola, M. (Markus), Viikari, J. S. (Jorma S.), Jalkanen, S. (Sirpa), Maksimow, M. (Mikael), Salomaa, V. (Veikko), Salmi, M. (Marko), Raitakari, O. T. (Olli T.), Kettunen, J. (Johannes), Timpson, N. J. (Nicholas J.), Kalaoja, M. (Marita), Corbin, L. J. (Laura J.), Tan, V. Y. (Vanessa Y.), Ahola‐Olli, A. V. (Ari V.), Havulinna, A. S. (Aki S.), Santalahti, K. (Kristiina), Pitkänen, N. (Niina), Lehtimäki, T. (Terho), Lyytikäinen, L. (Leo‐Pekka), Raitoharju, E. (Emma), Seppälä, I. (Ilkka), Kähönen, M. (Mika), Ripatti, S. (Samuli), Palotie, A. (Aarno), Perola, M. (Markus), Viikari, J. S. (Jorma S.), Jalkanen, S. (Sirpa), Maksimow, M. (Mikael), Salomaa, V. (Veikko), Salmi, M. (Marko), Raitakari, O. T. (Olli T.), Kettunen, J. (Johannes), and Timpson, N. J. (Nicholas J.)
Abstract: Objective: This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease. Methods: BMI and circulating levels of up to 41 cytokines were measured in individuals from three Finnish cohort studies (n = 8,293). Mendelian randomization (MR) was used to assess the impact of BMI on circulating cytokines and the impact of BMI‐driven cytokines on risk of obesity‐related diseases. Results: Observationally, BMI was associated with 19 cytokines. For every SD increase in BMI, causal effect estimates were strongest for hepatocyte growth factor, monocyte chemotactic protein‐1 (MCP‐1), and tumor necrosis factor–related apoptosis‐inducing ligand (TRAIL) and were as ratios of geometric means 1.13 (95% CI: 1.08‐1.19), 1.08 (95% CI: 1.04‐1.14), and 1.13 (95% CI: 1.04‐1.21), respectively. TRAIL was associated with a small increase in the odds of coronary artery disease (odds ratio: 1.03; 95% CI: 1.00‐1.06). There was inconsistent evidence for a protective role of MCP‐1 against inflammatory bowel diseases. Conclusions: Observational and MR estimates of the effect of BMI on cytokine levels were generally concordant. There was little evidence for an effect of raised levels of BMI‐driven cytokines on disease. These findings illustrate the challenges of MR when applied in the context of molecular mediation.
Published: 2021

20. Pair production of the fourth family charged sleptons at e(+)e(-) colliders

Author: Çakır, O., Ari, V., Çakır, I. T., Sultansoy, Saleh, Çakır, O., Ari, V., Çakır, I. T., and Sultansoy, Saleh
Abstract: We study the pair production of (l) over bar (4), which is the supersymmetric partner of the fourth family charged lepton, at the e(+)e(-) colliders. It is shown that the investigation of this process at ILC/CLIC will give the opportunity to differentiate the MSSM with three and four families. The ILC with root s = 1TeV and L-int = 1 ab(-1) has the potential for the observation of the fourth family slepton with mass up to 420 GeV, if the fourth SM family neutrino has a Dirac nature. The CLIC with root s = 3TeV and L-int = 1 ab(-1) will enlarge the observation region up to m((l) over bar4) = 580 GeV. Copyright (C) EPLA, 2011
Published: 2021

21. Pair production of the fourth family charged sleptons at e(+)e(-) colliders

Author: Çakır, I. T., Ari, V., Sultansoy, Saleh, Çakır, O., Çakır, I. T., Ari, V., Sultansoy, Saleh, and Çakır, O.
Abstract: We study the pair production of (l) over bar (4), which is the supersymmetric partner of the fourth family charged lepton, at the e(+)e(-) colliders. It is shown that the investigation of this process at ILC/CLIC will give the opportunity to differentiate the MSSM with three and four families. The ILC with root s = 1TeV and L-int = 1 ab(-1) has the potential for the observation of the fourth family slepton with mass up to 420 GeV, if the fourth SM family neutrino has a Dirac nature. The CLIC with root s = 3TeV and L-int = 1 ab(-1) will enlarge the observation region up to m((l) over bar4) = 580 GeV. Copyright (C) EPLA, 2011
Published: 2021

22. The Large Hadron-Electron Collider at the HL-LHC

Author: Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., Zurita, P., Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., and Zurita, P.
Abstract: The Large Hadron electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High Luminosity--Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operation. This report represents an update of the Conceptual Design Report (CDR) of the LHeC, published in 2012. It comprises new results on parton structure of the proton and heavier nuclei, QCD dynamics, electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics in extending the accessible kinematic range in lepton-nucleus scattering by several orders of magnitude. Due to enhanced luminosity, large energy and the cleanliness of the hadronic final states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, the report represents a detailed updated design of the energy recovery electron linac (ERL) including new lattice, magnet, superconducting radio frequency technology and further components. Challenges of energy recovery are described and the lower energy, high current, 3-turn ERL facility, PERLE at Orsay, is presented which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution and calibration goals which arise from the Higgs and parton density function physics programmes. The paper also presents novel results on the Future Circular Collider in electron-hadron mode, FCC-eh, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies., Comment: 373 pages, many figures, to be published by J. Phys. G
Published: 2020
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23. Sensitivity physics expected to the measurement of the quartic $WW\gamma\gamma$ couplings at the LHeC and the FCC-he

Author: Gurkanli, E., Ari, V., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., Koksal, M., Gurkanli, E., Ari, V., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., and Koksal, M.
Abstract: We explore the physics expected sensitivity at the Large Hadron electron Collider (LHeC) and the Future Circular Collider-hadron electron (FCC-he) to search for the anomalous quartic $WW\gamma\gamma$ couplings in single $W$-boson production in association with a photon. We study the process $ep \to e^-\gamma^* p \to eW\gamma q'X$ via the subprocess $\gamma^* q \to W\gamma q'$. The center-of-mass energies and luminosities of the LHeC are assumed to be $\sqrt{s}=1.30, 1.98$ TeV, ${\cal L}=10-100$ ${\rm fb^{-1} }$ and for the FCC-he $\sqrt{s}=3.46, 5.29$ TeV and ${\cal L}=100-1000$ ${\rm fb^{-1} }$. With these energies and luminosities, we estimate bounds on the anomalous quartic $WW\gamma\gamma$ couplings at $95\%$ C.L., which can be an order of magnitude stringent than the experimental limits report by ATLAS and CMS Collaborations at the LHC., Comment: 28 pages, 10 figures. arXiv admin note: text overlap with arXiv:1211.3100 by other authors
Published: 2020
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24. Single Production of Vectorlike Y Quarks at the HL-LHC

Author: Cetinkaya, V., Ozansoy, A., Ari, V., Ozsimsek, O. M., Cakir, O., Cetinkaya, V., Ozansoy, A., Ari, V., Ozsimsek, O. M., and Cakir, O.
Abstract: We study single production of exotic vectorlike $Y$ quark with electric charge $|Q_{Y}|=4/3$ and its subsequent decay at the High Luminosity LHC (HL-LHC). Most of the vector like quark (VLQ) decays have the electroweak $W$ bosons in the intermediate state. Besides their direct productions singly or pairs, the $W$-bosons are involved in decay chains as a result of the decay of a top quark which contributes to the background. This is particularly the case since vectorlike $Y$ quark, which is estimated to be produced with a high cross-section, can only decay via a $W$ boson and a down type quark ($d,s,b$). We calculate the cross sections of signal (for different couplings and mass values) and relevant Standard Model (SM) backgrounds. After a fast simulation of signal and background events, estimations of the sensitivity to the parameters (mass range 1000-2500 GeV for coupling value $\kappa_{Y}=0.5$, and mass range 500-2000 GeV for coupling values $\kappa_{Y}=0.3$ and $\kappa_{Y}=0.15$) have been presented at the HL-LHC with center of mass energy $\sqrt{s}=14$ TeV and integrated luminosity projections of 300 fb$^{-1}$, 1000 fb$^{-1}$ and 3000 fb$^{-1}$., Comment: 14 pages, 21 figures
Published: 2020
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25. The Large Hadron-Electron Collider at the HL-LHC

Author: Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., Zurita, P., Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., and Zurita, P.
Abstract: The Large Hadron electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High Luminosity--Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operation. This report represents an update of the Conceptual Design Report (CDR) of the LHeC, published in 2012. It comprises new results on parton structure of the proton and heavier nuclei, QCD dynamics, electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics in extending the accessible kinematic range in lepton-nucleus scattering by several orders of magnitude. Due to enhanced luminosity, large energy and the cleanliness of the hadronic final states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, the report represents a detailed updated design of the energy recovery electron linac (ERL) including new lattice, magnet, superconducting radio frequency technology and further components. Challenges of energy recovery are described and the lower energy, high current, 3-turn ERL facility, PERLE at Orsay, is presented which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution and calibration goals which arise from the Higgs and parton density function physics programmes. The paper also presents novel results on the Future Circular Collider in electron-hadron mode, FCC-eh, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies., Comment: 373 pages, many figures, to be published by J. Phys. G
Published: 2020
Full Text: View/download PDF

26. Study on the anomalous quartic $W^+W^-\gamma\gamma$ couplings of electroweak bosons in $e^-p$ collisions at the LHeC and the FCC-he

Author: Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., Gurkanli, E., Ari, V., Köksal, M., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., Gurkanli, E., Ari, V., and Köksal, M.
Abstract: In this paper, a study is carried out on the $e^-p \to e^-\gamma^* p \to p W^+\gamma \nu_e$ production to probe quartic $W^+W^-\gamma\gamma$ couplings using 10, 100 ${\rm fb^{-1}}$ of $e^-p$ collisions data at $\sqrt{s}$= 1.30, 1.98 GeV at the Large Hadron electron Collider (LHeC) and 100, 1000 ${\rm fb^{-1}}$ with $\sqrt{s}$= 3.46, 5.29 GeV at the Future Circular Collider-hadron electron (FCC-he). Production cross-sections are determined for both at leptonic and hadronic decay channel of the $W$-boson. With the data from future $e^-p$ colliders, it is possible to obtain sensitivity measures at $95\%$ C.L. on the anomalous $f_ {M,i}/\Lambda^4$ and $ f_ {T,i}/\Lambda^4$ couplings which are competitive with the limits obtained by the LHC, as well as with others limits reported in the literature. The production mode $e^-p \to e^-\gamma^* p \to p W^+\gamma \nu_e $ in $e^-p$ collisions offers a window for study the quartic $W^+W^-\gamma\gamma$ electroweak bosons couplings at the LHeC and the FCC-he, which provides a much cleaner collision environment than the LHC., Comment: 27 pages , 10 figures
Published: 2020
Full Text: View/download PDF

27. The Large Hadron-Electron Collider at the HL-LHC

Author: Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., Zurita, P., Agostini, P., Aksakal, H., Alekhin, S., Allport, P. P., Andari, N., Andre, K. D. J., Angal-Kalinin, D., Antusch, S., Bella, L. Aperio, Apolinario, L., Apsimon, R., Apyan, A., Arduini, G., Ari, V., Armbruster, A., Armesto, N., Auchmann, B., Aulenbacher, K., Azuelos, G., Backovic, S., Bailey, I., Bailey, S., Balli, F., Behera, S., Behnke, O., Ben-Zvi, I., Benedikt, M., Bernauer, J., Bertolucci, S., Biswal, S. S., Blümlein, J., Bogacz, A., Bonvini, M., Boonekamp, M., Bordry, F., Boroun, G. R., Bottura, L., Bousson, S., Bouzas, A. O., Bracco, C., Bracinik, J., Britzger, D., Brodsky, S. J., Bruni, C., Brüning, O., Burkhardt, H., Cakir, O., Calaga, R., Caldwell, A., Calıskan, A., Camarda, S., Catalan-Lasheras, N. C., Cassou, K., Cepila, J., Cetinkaya, V., Chetvertkova, V., Cole, B., Coleppa, B., Cooper-Sarkar, A., Cormier, E., Cornell, A. S., Corsini, R., Cruz-Alaniz, E., Currie, J., Curtin, D., D'Onofrio, M., Dainton, J., Daly, E., Das, A., Das, S. P., Dassa, L., de Blas, J., Rose, L. Delle, Denizli, H., Deshpande, K. S., Douglas, D., Duarte, L., Dupraz, K., Dutta, S., Efremov, A. V., Eichhorn, R., Eskola, K. J., Ferreiro, E. G., Fischer, O., Flores-Sánchez, O., Forte, S., Gaddi, A., Gao, J., Gehrmann, T., Ridder, A. Gehrmann-De, Gerigk, F., Gilbert, A., Giuli, F., Glazov, A., Glover, N., Godbole, R. M., Goddard, B., Gonçalves, V., Gonzalez-Sprinberg, G. A., Goyal, A., Grames, J., Granados, E., Grassellino, A., Gunaydin, Y. O., Guo, Y. C., Guzey, V., Gwenlan, C., Hammad, A., Han, C. C., Harland-Lang, L., Haug, F., Hautmann, F., Hayden, D., Hessler, J., Helenius, I., Henry, J., Hernandez-Sanchez, J., Hesari, H., Hobbs, T. J., Hod, N., Hoffstaetter, G. H., Holzer, B., Honorato, C. G., Hounsell, B., Hu, N., Hug, F., Huss, A., Hutton, A., Islam, R., Iwamoto, S., Jana, S., Jansova, M., Jensen, E., Jones, T., Jowett, J. M., Kaabi, W., Kado, M., Kalinin, D. A., Karadeniz, H., Kawaguchi, S., Kaya, U., Khalek, R. A., Khanpour, H., Kilic, A., Klein, M., Klein, U., Kluth, S., Köksal, M., Kocak, F., Korostelev, M., Kostka, P., Krelina, M., Kretzschmar, J., Kuday, S., Kulipanov, G., Kumar, M., Kuze, M., Lappi, T., Larios, F., Latina, A., Laycock, P., Lei, G., Levitchev, E., Levonian, S., Levy, A., Li, R., Li, X., Liang, H., Litvinenko, V., Liu, M., Liu, T., Liu, W., Liu, Y., Liuti, S., Lobodzinska, E., Longuevergne, D., Luo, X., Ma, W., Machado, M., Mandal, S., Mäntysaari, H., Marhauser, F., Marquet, C., Martens, A., Martin, R., Marzani, S., McFayden, J., Mcintosh, P., Mellado, B., Meot, F., Milanese, A., Milhano, J. G., Militsyn, B., Mitra, M., Moch, S., Najafabadi, M. Mohammadi, Mondal, S., Moretti, S., Morgan, T., Morreale, A., Nadolsky, P., Navarra, F., Nergiz, Z., Newman, P., Niehues, J., Nissen, E. A., Nowakowski, M., Okada, N., Olivier, G., Olness, F., Olry, G., Osborne, J. A., Ozansoy, A., Pan, R., Parker, B., Patra, M., Paukkunen, H., Peinaud, Y., Pellegrini, D., Perez-Segurana, G., Perini, D., Perrot, L., Pietralla, N., Pilicer, E., Pire, B., Pires, J., Placakyte, R., Poelker, M., Polifka, R., Polini, A., Poulose, P., Pownall, G., Pupkov, Y. A., Queiroz, F. S., Rabbertz, K., Radescu, V., Rahaman, R., Rai, S. K., Raicevic, N., Ratoff, P., Rashed, A., Raut, D., Raychaudhuri, S., Repond, J., Rezaeian, A. H., Rimmer, R., Rinolfi, L., Rojo, J., Rosado, A., Ruan, X., Russenschuck, S., Sahin, M., Salgado, C. A., Sampayo, O. A., Satendra, K., Satyanarayan, N., Schenke, B., Schirm, K., Schopper, H., Schott, M., Schulte, D., Schwanenberger, C., Sekine, T., Senol, A., Seryi, A., Setiniyaz, S., Shang, L., Shen, X., Shipman, N., Sinha, N., Slominski, W., Smith, S., Solans, C., Song, M., Spiesberger, H., Stanyard, J., Starostenko, A., Stasto, A., Stocchi, A., Strikman, M., Stuart, M. J., Sultansoy, S., Sun, H., Sutton, M., Szymanowski, L., Tapan, I., Tapia-Takaki, D., Tanaka, M., Tang, Y., Tasci, A. T., Ten-Kate, A. T., Thonet, P., Tomas-Garcia, R., Tommasini, D., Trbojevic, D., Trott, M., Tsurin, I., Tudora, A., Cakir, I. Turk, Tywoniuk, K., Vallerand, C., Valloni, A., Verney, D., Vilella, E., Walker, D., Wallon, S., Wang, B., Wang, K., Wang, X., Wang, Z. S., Wei, H., Welsch, C., Willering, G., Williams, P. H., Wollmann, D., Xiaohao, C., Xu, T., Yaguna, C. E., Yamaguchi, Y., Yamazaki, Y., Yang, H., Yilmaz, A., Yock, P., Yue, C. X., Zadeh, S. G., Zenaiev, O., Zhang, C., Zhang, J., Zhang, R., Zhang, Z., Zhu, G., Zhu, S., Zimmermann, F., Zomer, F., Zurita, J., and Zurita, P.
Abstract: The Large Hadron electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High Luminosity--Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron-proton and proton-proton operation. This report represents an update of the Conceptual Design Report (CDR) of the LHeC, published in 2012. It comprises new results on parton structure of the proton and heavier nuclei, QCD dynamics, electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics in extending the accessible kinematic range in lepton-nucleus scattering by several orders of magnitude. Due to enhanced luminosity, large energy and the cleanliness of the hadronic final states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, the report represents a detailed updated design of the energy recovery electron linac (ERL) including new lattice, magnet, superconducting radio frequency technology and further components. Challenges of energy recovery are described and the lower energy, high current, 3-turn ERL facility, PERLE at Orsay, is presented which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution and calibration goals which arise from the Higgs and parton density function physics programmes. The paper also presents novel results on the Future Circular Collider in electron-hadron mode, FCC-eh, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies., Comment: 373 pages, many figures, to be published by J. Phys. G
Published: 2020
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28. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Author: Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, and Kleineidam, Luca
Abstract: Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
Published: 2019

29. FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

Author: Abada, A., Abbrescia, M., AbdusSalam, S. S., Abdyukhanov, I., Fernandez, J. Abelleira, Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Fernandez, R. M. Alemany, Alexahin, Y., Alia, R. G., Alioli, S., Tehrani, N. Alipour, Allanach, B. C., Allport, P. P., Altinli, M., Altmannshofer, W., Ambrosio, G., Amorim, D., Amstutz, O., Anderlini, L., Andreazza, A., Andreini, M., Andriatis, A., Andris, C., Andronic, A., Angelucci, M., Antinori, F., Antipov, S. A., Antonelli, M., Antonello, M., Antonioli, P., Antusch, S., Anulli, F., Apolinario, L., Apollinari, G., Apollonio, A., Appelo, D., Appleby, R. B., Apyan, Ara., Apyan, Arm., Arbey, A., Arbuzov, A., Arduini, G., Ari, V., Arias, S., Armesto, N., Arnaldi, R., Arsenyev, S. A., Arzeo, M., Asai, S., Aslanides, E., Assmann, R. W., Astapovych, D., Atanasov, M., Atieh, S., Attie, D., Auchmann, B., Audurier, A., Aull, S., Aumon, S., Aune, S., Avino, F., Avrillaud, G., Aydin, G., Azatov, A., Azuelos, G., Azzi, P., Azzolini, O., Azzurri, P., Bacchetta, N., Bacchiocchi, E., Bachacou, H., Baek, Y. W., Baglin, V., Bai, Y., Baird, S., Baker, M. J., Baldwin, M. J., Ball, A. H., Ballarino, A., Banerjee, S., Barber, D. P., Barducci, D., Barjhoux, P., Barna, D., Barnafoldi, G. G., Barnes, M. J., Barr, A., Garcia, J. Barranco, da Costa, J. Barreiro Guimaraes, Bartmann, W., Baryshevsky, V., Barzi, E., Bass, S. A., Bastianin, A., Baudouy, B., Bauer, F., Bauer, M., Baumgartner, T., Bautista-Guzman, I., Bayindir, C., Beaudette, F., Bedeschi, F., Beguin, M., Bellafont, I., Bellagamba, L., Bellegarde, N., Belli, E., Bellingeri, E., Bellini, F., Bellomo, G., Belomestnykh, S., Bencivenni, G., Benedikt, M., Bernardi, G., Bernardi, J., Bernet, C., Bernhardt, J. M., Bernini, C., Berriaud, C., Bertarelli, A., Bertolucci, S., Besana, M. I., Besancon, M., Beznosov, O., Bhat, P., Bhat, C., Biagini, M. E., Biarrotte, J. -L., Chevalier, A. Bibet, Bielert, E. R., Biglietti, M., Bilei, G. M., Bilki, B., Biscari, C., Bishara, F., Blanco-Garcia, O. R., Blanquez, F. R., Blekman, F., Blondel, A., Blumlein, J., Boccali, T., Boels, R., Bogacz, S. A., Bogomyagkov, A., Boine-Frankenheim, O., Boland, M. J., Bologna, S., Bolukbasi, O., Bomben, M., Bondarenko, S., Bonvini, M., Boos, E., Bordini, B., Bordry, F., Borghello, G., Borgonovi, L., Borowka, S., Bortoletto, D., Boscherini, D., Boscolo, M., Boselli, S., Bosley, R. R., Bossu, F., Botta, C., Bottura, L., Boughezal, R., Boutin, D., Bovone, G., Jelisavcic, I. Bozovic, Bozbey, A., Bozzi, C., Bozzini, D., Braccini, V., Braibant-Giacomelli, S., Bramante, J., Braun-Munzinger, P., Briffa, J. A., Britzger, D., Brodsky, S. J., Brooke, J. J., Bruce, R., De Renstrom, P. Bruckman, Bruna, E., Bruning, O., Brunner, O., Brunner, K., Bruzzone, P., Buffat, X., Bulyak, E., Burkart, F., Burkhardt, H., Burnet, J. -P., Butin, F., Buttazzo, D., Butterworth, A., Caccia, M., Cai, Y., Caiffi, B., Cairo, V., Cakir, O., Calaga, R., Calatroni, S., Calderini, G., Calderola, G., Caliskan, A., Calvet, D., Calviani, M., Camalich, J. M., Camarri, P., Campanelli, M., Camporesi, T., Canbay, A. C., Canepa, A., Cantergiani, E., Cantore-Cavalli, D., Capeans, M., Cardarelli, R., Cardella, U., Cardini, A., Calame, C. M. Carloni, Carra, F., Carra, S., Carvalho, A., Casalbuoni, S., Casas, J., Cascella, M., Castelnovo, P., Castorina, G., Catalano, G., Cavasinni, V., Cazzato, E., Cennini, E., Cerri, A., Cerutti, F., Cervantes, J., Chaikovska, I., Chakrabortty, J., Chala, M., Chamizo-Llatas, M., Chanal, H., Chanal, D., Chance, S., Chance, A., Charitos, P., Charles, J., Charles, T. K., Chattopadhyay, S., Chehab, R., Chekanov, S. V., Chen, N., Chernoded, A., Chetvertkova, V., Chevalier, L., Chiarelli, G., Chiarello, G., Chiesa, M., Chiggiato, P., Childers, J. T., Chmielinska, A., Cholakian, A., Chomaz, P., Chorowski, M., Chou, W., Chrzaszcz, M., Chyhyrynets, E., Cibinetto, G., Ciftci, A. K., Ciftci, R., Cimino, R., Ciuchini, M., Clark, P. J., Coadou, Y., Cobal, M., Coccaro, A., Cogan, J., Cogneras, E., Collamati, F., Colldelram, C., Collier, P., Collot, J., Contino, R., Conventi, F., Cook, C. T. A., Cooley, L., Corcella, G., Cornell, A. S., Corral, G. H., Correia-Rodrigues, H., Costanza, F., Pinto, P. Costa, Couderc, F., Coupard, J., Craig, N., Crespo Garrido, I., Crivellin, A., Croteau, J. F., Crouch, M., Alaniz, E. Cruz, Cure, B., Curti, J., Curtin, D., Czech, M., Dachauer, C., D'Agnolo, R. T., Daibo, M., Dainese, A., Dalena, B., Daljevec, A., Dallapiazza, W., Schwartzentruber, L. D'Aloia, Dam, M., D'Ambrosio, G., Das, S. P., DasBakshi, S., da Silva, W., da Silveira, G. G., D'Auria, V., D'Auria, S., David, A., Davidek, T., Deandrea, A., de Blas, J., Debono, C. J., De Curtis, S., De Filippis, N., de Florian, D., Deghaye, S., de Jong, S. J., Bo, C. Del, Duca, V. Del, Delikaris, D., Deliot, F., Dell'Acqua, A., Rose, L. Delle, Delmastro, M., De Lucia, E., Demarteau, M., Denegri, D., Deniau, L., Denisov, D., Denizli, H., Denner, A., d'Enterria, D., de Rijk, G., De Roeck, A., Derue, F., Deschamps, O., Descotes-Genon, S., Dev, P. S. B., de Regie, J. B. de Vivie, Dewanjee, R. K., Ciaccio, A. Di, Cicco, A. Di, Dillon, B. M., Micco, B. Di, Nezza, P. Di, Vita, S. Di, Doblhammer, A., Dominjon, A., D'Onofrio, M., Dordei, F., Drago, A., Draper, P., Drasal, Z., Drewes, M., Duarte, L., Dubovyk, I., Duda, P., Dudarev, A., Dudko, L., Duellmann, D., Duenser, M., du Pree, T., Durante, M., Yildiz, H. Duran, Dutta, S., Duval, F., Duval, J. M., Dydyshka, Ya., Dziewit, B., Eisenhardt, S., Eisterer, M., Ekelof, T., Khechen, D. El, Ellis, S. A., Ellis, J., Ellison, J. A., Elsener, K., Elsing, M., Enari, Y., Englert, C., Eriksson, H., Eskola, K. J., Esposito, L. S., Etisken, O., Etzion, E., Fabbricatore, P., Falkowski, A., Falou, A., Faltova, J., Fan, J., Fano, L., Farilla, A., Farinelli, R., Farinon, S., Faroughy, D. A., Fartoukh, S. D., Faus-Golfe, A., Fawcett, W. J., Felici, G., Felsberger, L., Ferdeghini, C., Fernandez Navarro, A. M., Fernandez-Tellez, A., Troitino, J. Ferradas, Ferrara, G., Ferrari, R., Ferreira, L., da Silva, P. Ferreira, Ferrera, G., Ferro, F., Fiascaris, M., Fiorendi, S., Fiorio, C., Fischer, O., Fischer, E., Flieger, W., Florio, M., Fonnesu, D., Fontanesi, E., Foppiani, N., Foraz, K., Forkel-Wirth, D., Forte, S., Fouaidy, M., Fournier, D., Fowler, T., Fox, J., Francavilla, P., Franceschini, R., Franchino, S., Franco, E., Freitas, A., Fuks, B., Furukawa, K., Furuseth, S. V., Gabrielli, E., Gaddi, A., Galanti, M., Gallo, E., Ganjour, S., Gao, Jia., Gao, Jie., Diaz, V. Garcia, Perez, M. Garcia, Garcia Tabares, L., Garion, C., Garzelli, M. V., Garzia, I., Gascon-Shotkin, S. M., Gaudio, G., Gay, P., Ge, S. -F., Gehrmann, T., Genest, M. H., Gerard, R., Gerigk, F., Gerwig, H., Giacomelli, P., Giagu, S., Gianfelice-Wendt, E., Gianotti, F., Giffoni, F., Gilardoni, S. S., Gil Costa, M., Giovannetti, M., Giovannozzi, M., Giubellino, P., Giudice, G. F., Giunta, A., Gladilin, L. K., Glukhov, S., Gluza, J., Gobbi, G., Goddard, B., Goertz, F., Golling, T., Goncalves, D., Goncalves, V. P., Goncalo, R., Gomez, L. A. Gonzalez, Zadeh, S. Gorgi, Gorine, G., Gorini, E., Gourlay, S. A., Gouskos, L., Grancagnolo, F., Grassellino, A., Grau, A., Graverini, E., Gray, H. M., Greco, Ma., Greco, Mi., Grenard, J. -L., Grimm, O., Grojean, C., Gromov, V. A., Grosse-Oetringhaus, J. F., Grudiev, A., Grzanka, K., Gu, J., Guadagnoli, D., Guidi, V., Guiducci, S., Guillermo Canton, G., Gunaydin, Y. O., Gupta, R., Gupta, R. S., Gutierrez, J., Gutleber, J., Guyot, C., Guzey, V., Gwenlan, C., Haberstroh, Ch., Hacisahinoglu, B., Haerer, B., Hahn, K., Hahn, T., Hammad, A., Han, C., Hance, M., Hannah, A., Harris, P. C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H-J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, Ana., Henriques, And., Hernandez, P., Hernandez-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Hofle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Bermudez, S. Izquierdo, Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jimenez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. O., Karadeniz, H., Karaventzas, V., Karpov, I., Kartal, S., Karyukhin, A., Kashikhin, V., Behr, J. Katharina, Kaya, U., Keintzel, J., Keinz, P. A., Keppel, K., Kersevan, R., Kershaw, K., Khanpour, H., Khatibi, S., Yanehsari, M. Khatiri, Khoze, V. V., Kieseler, J., Kilic, A., Kilpinen, A., Kim, Y. -K., Kim, D. W., Klein, U., Klein, M., Kling, F., Klinkenberg, N., Kloeppel, S., Klute, M., Klyukhin, V. I., Knecht, M., Kniehl, B., Kocak, F., Koeberl, C., Kolano, A. M., Kollegger, A., Kolodziej, K., Kolomiets, A. A., Komppula, J., Koop, I., Koppenburg, P., Koratzinos, M., Kordiaczynska, M., Korjik, M., Kortner, O., Kostka, P., Kotlarski, W., Kotnig, C., Kottig, T., Kotwal, A. V., Kovalenko, A. D., Kowalski, S., Kozaczuk, J., Kozlov, G. A., Kozub, S. S., Krainer, A. M., Kramer, T., Kraemer, M., Krammer, M., Krasnov, A. A., Krauss, F., Kravalis, K., Kretzschmar, L., Kriske, R. M., Kritscher, H., Krkotic, P., Kroha, H., Kucharczyk, M., Kuday, S., Kuendig, A., Kuhlmann, G., Kulesza, A., Kumar, Mi., Kumar, Mu., Kusina, A., Kuttimalai, S., Kuze, M., Kwon, T., Lackner, F., Lackner, M., La Francesca, E., Laine, M., Lamanna, G., La Mendola, S., Lancon, E., Landsberg, G., Langacker, P., Lange, C., Langner, A., Lankford, A. J., Lansberg, J. P., Lari, T., Laycock, P. J., Lebrun, P., Lechner, A., Lee, K., Lee, S., Lee, R., Lefevre, T., Guen, P. Le, Lehtinen, T., Leith, S. B., Lenzi, P., Leogrande, E., Leonidopoulos, C., Leon-Monzon, I., Lerner, G., Leroy, O., Lesiak, T., Levai, P., Leveratto, A., Levichev, E., Li, G., Li, S., Li, R., Liberati, D., Liepe, M., Lissauer, D. A., Liu, Z., Lobko, A., Locci, E., Agaliotis, E. Logothetis, Lombardo, M. P., Long, A. J., Lorin, C., Losito, R., Louzguiti, A., Low, I., Lucchesi, D., Lucchini, M. T., Luciani, A., Lueckhof, M., Lunt, A. J. G., Luzum, M., Lyubimtsev, D. A., Maggiora, M., Magnin, N., Mahmoud, M. A., Mahmoudi, F., Maitre, J., Makarenko, V., Malagoli, A., Malcles, J., Malgeri, L., Mallon, P. J., Maltoni, F., Malvezzi, S., Malyshev, O. B., Mancinelli, G., Mandrik, P., Manfrinetti, P., Mangano, M., Manil, P., Mannelli, M., Marchiori, G., Marhauser, F., Mariani, V., Marinozzi, V., Mariotto, S., Marquard, P., Marquet, C., Marriott-Dodington, T., Martin, R., Martin, O., Martin Camalich, J., Martinez, T., Bruzual, H. Martinez, Martinez-Hernandez, M. I., Martins, D. E., Marzani, S., Marzocca, D., Marzola, L., Masciocchi, S., Masina, I., Massimiliano, A., Massironi, A., Masubuchi, T., Matveev, V. A., Mazzoni, M. A., McCullough, M., McIntosh, P. A., Meade, P., Medina, L., Meier, A., Meignan, J., Mele, B., Mendes Saraiva, J. G., Menez, F., Mentink, M., Meoni, E., Meridiani, P., Merk, M., Mermod, P., Mertens, V., Mether, L., Metral, E., Migliorati, M., Milanese, A., Milardi, C., Milhano, G., Militsyn, B. L., Millet, F., Minashvili, I., Minervini, J. V., Miralles, L. S., Mirarchi, D., Mishima, S., Missiaen, D. P., Mitselmakher, G., Mitsuhashi, T., Mnich, J., Najafabadi, M. Mohammadi, Mohapatra, R. N., Mokhov, N., Molson, J. G., Monge, R., Montag, C., Montagna, G., Monteil, S., Montenero, G., Montesinos, E., Moortgat, F., Morange, N., Morello, G., Llacer, M. Moreno, Moretti, M., Moretti, S., Morley, A. K., Moros, A., Morozov, I., Morretta, V., Morrone, M., Mostacci, A., Muanza, S., Muchnoi, N., Muehlegger, M., Mulder, M., Mulders, M., Mueller, B., Mueller, F., Mueller, A. -S., Munilla, J., Murray, M. J., Muttoni, Y., Myers, S., Mylona, M., Nachtman, J., Nakamoto, T., Nardecchia, M., Nardini, G., Nason, P., Nergiz, Z., Nesterenko, A. V., Nettstraeter, A., Neubuser, C., Neundorf, J., Niccoli, F., Nicrosini, O., Nie, Y., Niedermayer, U., Niedziela, J., Niemi, A., Nikitin, S. A., Nisati, A., No, J. M., Nonis, M., Nosochkov, Y., Novak, M., Novokhatski, A., O'Callaghan, J. M., Ochando, C., Ogur, S., Ohmi, K., Oide, K., Okorokov, V. A., Okumura, Y., Oleari, C., Olness, F. I., Onel, Y., Ortino, M., Osborne, J., Osland, P., Otto, T., Oyulmaz, K. Y., Ozansoy, A., Ozcan, V., Ozdemir, K., Pagliarone, C. E., da Silva, H. F. Pais, Palmieri, E., Palumbo, L., Pampaloni, A., Pan, R. -Q., Panareo, M., Panella, O., Panico, G., Panizzo, G., Pankov, A. A., Pantsyrny, V., Papadopoulos, C. G., Papaefstathiou, A., Papaphilippou, Y., Parker, M. A., Parma, V., Pasquali, M., Patra, S. K., Patterson, R., Paukkunen, H., Pauss, F., Peggs, S., Penttinen, J. -P., Peon, G., Perepelkin, E. E., Perez, E., Perez, J. C., Perez, G., Perez, F., Codina, E. Perez, Perez Morales, J., Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Placzek, W., Plagge, M., Plehn, T., Pleier, M. -A., Ploskon, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Lener, M. Poli, Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Pulawski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramirez-Uribe, N. S., Ramsey-Musolf, M. J., Rata, R., Ratoff, P., Ravotti, F., Rebello Teles, P., Reboud, M., Redaelli, S., Renner, E., Renteria-Olivo, A. E., Rescigno, M., Reuter, J., Ribon, A., Ricci, A. M., Riegler, W., Riemann, S., Riemann, B., Riemann, T., Rifflet, J. M., Rimmer, R. A., Rinaldesi, R., Rinolfi, L., Rubiras, O. Rios, Risselada, T., Rivetti, A., Rivkin, L., Rizzo, T., Robens, T., Robert, F., Robson, A. J., Rochepault, E., Roda, C., Rodrigo, G., Rodriguez-Cahuantzi, M., Rogan, C., Roig, M., Rojas-Torres, S., Rojo, J., Rolandi, G., Rolando, G., Roloff, P., Romanenko, A., Romanov, A., Roncarolo, F., Rosado Sanchez, A., Rosaz, G., Rossi, L., Rossi, A., Rossmanith, R., Rousset, B., Royon, C., Ruan, X., Ruehl, I., Ruhlmann-Kleider, V., Ruiz, R., Rumyantsev, L., Ruprecht, R., Ryazanov, A. I., Saba, A., Sadykov, R., de Jauregui, D. Saez, Sahin, M., Sailer, B., Saito, M., Sala, F., Salam, G. P., Salfeld-Nebgen, J., Salgado, C. A., Salini, S., Sallese, J. M., Salmi, T., Salzburger, A., Sampayo, O. A., Sanfilippo, S., Santiago, J., Santopinto, E., Santoro, R., Ull, A. Sanz, Sarasola, X., Sarpun, I. H., Sauvain, M., Savelyeva, S., Sawada, R., Sborlini, G. F. R., Schaffer, A., Schaumann, M., Schenk, M., Scheuerlein, C., Schienbein, I., Schlenga, K., Schmickler, H., Schmidt, R., Schoerling, D., Schoning, A., Schoerner-Sadenius, T., Schott, M., Schulte, D., Schwaller, P., Schwanenberger, C., Schwemling, P., Schwerg, N., Scibile, L., Sciuto, A., Scomparin, E., Sebastiani, C., Seeber, B., Segreti, M., Selva, P., Selvaggi, M., Senatore, C., Senol, A., Serin, L., Serluca, M., Serra, N., Seryi, A., Sestini, L., Sfyrla, A., Shaposhnikov, M., Shaposhnikova, E., Sharkov, B. Yu., Shatilov, D., Shelton, J., Shiltsev, V., Shipsey, I. P., Shirkov, G. D., Shivaji, A., Shwartz, D., Sian, T., Sidorov, S., Siemko, A., Silvestrini, L., Simand, N., Simon, F., Singh, B. K., Siodmok, A., Sirois, Y., Sirtori, E., Sirvinskaite, R., Sitar, B., Sjoestrand, T., Skands, P., Skordis, E., Skovpen, K., Skrzypek, M., Slade, E., Slavich, P., Slovak, R., Smaluk, V., Smirnov, V., Snoeys, W., Soffi, L., Sollander, P., Solovyanov, O., Soltveit, H. K., Song, H., Sopicki, P., Sorbi, M., Spallino, L., Spannowsky, M., Spataro, B., Sphicas, P., Spiesberger, H., Spiller, P., Spira, M., Srivastava, T., Stachel, J., Stakia, A., Stanyard, J. L., Starchenko, E., Starikov, A. Yu., Stasto, A. M., Statera, M., Steerenberg, R., Steggemann, J., Stenvall, A., Stivanello, F., Stoeckinger, D., Stoel, L. S., Stoeger-Pollach, M., Strauss, B., Stuart, M., Stupakov, G., Su, S., Sublet, A., Sugita, K., Sulak, L., Sullivan, M. K., Sultansoy, S., Sumida, T., Suzuki, K., Sylva, G., Syphers, M. J., Sznajder, A., Taborelli, M., Tahir, N. A., Hod, E. Tal, Takeuchi, M., Tambasco, C., Tanaka, J., Tang, K., Tapan, I., Taroni, S., Tartarelli, G. F., Tassielli, G., Tavian, L., Taylor, T. M., Taylor, G. N., Teixeira, A. M., Tejeda-Munoz, G., Telnov, V. I., Tenchini, R., ten Kate, H. H. J., Terashi, K., Tesi, A., Testa, M., Tetrel, C., Teytelman, D., Thaler, J., Thamm, A., Thomas, S., Tiirakari, M. T., Tikhomirov, V., Tikhonov, D., Timko, H., Tisserand, V., Tkachenko, L. M., Tkaczuk, J., Tock, J. Ph., Todd, B., Todesco, E., Garcia, R. Tomas, Tommasini, D., Tonelli, G., Toral, F., Torims, T., Torre, R., Townsend, Z., Trant, R., Treille, D., Trentadue, L., Tricoli, A., Tricomi, A., Trischuk, W., Tropin, I. S., Tuchming, B., Tudora, A. A., Turbiarz, B., Cakir, I. Turk, Turri, M., Tydecks, T., Usovitsch, J., Uythoven, J., Vaglio, R., Valassi, A., Valchkova, F., Valdivia Garcia, M. A., Valente, P., Valente, R. U., Valente-Feliciano, A. -M., Valentino, G., Silva, L. Vale, Valet, J. M., Valizadeh, R., Valle, J. W. F., Vallecorsa, S., Vallone, G., van Leeuwen, M., van Rienen, U. H., van Riesen-Haupt, L., Varasteh, M., Vecchi, L., Vedrine, P., Velev, G., Veness, R., Ventura, A., Delsolaro, W. Venturini, Verducci, M., Verhaaren, C. B., Vernieri, C., Verweij, A. P., Verwilligen, O., Viazlo, O., Vicini, A., Viehhauser, G., Vignaroli, N., Vignolo, M., Vitrano, A., Vivarelli, I., Vlachos, S., Vogel, M., Vogt, D. M., Voelkl, V., Volkov, P., Volpini, G., von Ahnen, J., Vorotnikov, G., Voutsinas, G. G., Vysotsky, V., Wagner, U., Wallny, R., Wang, L. -T., Wang, R., Wang, K., Ward, B. F. L., Watson, T. P., Watson, N. K., Was, Z., Weiland, C., Weinzierl, S., Welsch, C. P., Wenninger, J., Widorski, M., Wiedemann, U. A., Wienands, H. -U., Wilkinson, G., Williams, P. H., Winter, A., Wohlfahrt, A., Wojton, T., Wollmann, D., Womersley, J., Woog, D., Wu, X., Wulzer, A., Yanehsari, M. K., Yang, G., Yang, H. J., Yao, W. -M., Yazgan, E., Yermolchik, V., Yilmaz, Ay., Yilmaz, Al., Yoo, H. -D., Yost, S. A., You, T., Young, C., Yu, T. -T., Yu, F., Zaborowska, A., Zadeh, S. G., Zahnd, M., Zanetti, M., Zanotto, L., Zawiejski, L., Zeiler, P., Zerlauth, M., Zernov, S. M., Porta, G. Zevi Dell, Zhang, Z., Zhang, Y., Zhang, C., Zhang, H., Zhao, Z., Zhong, Y. -M., Zhou, J., Zhou, D., Zhuang, P., Zick, G., Zimmermann, F., Zinn-Justin, J., Zivkovic, L., Zlobin, A. V., Zobov, M., Zupan, J., Zurita, J., Abada, A., Abbrescia, M., AbdusSalam, S. S., Abdyukhanov, I., Fernandez, J. Abelleira, Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Fernandez, R. M. Alemany, Alexahin, Y., Alia, R. G., Alioli, S., Tehrani, N. Alipour, Allanach, B. C., Allport, P. P., Altinli, M., Altmannshofer, W., Ambrosio, G., Amorim, D., Amstutz, O., Anderlini, L., Andreazza, A., Andreini, M., Andriatis, A., Andris, C., Andronic, A., Angelucci, M., Antinori, F., Antipov, S. A., Antonelli, M., Antonello, M., Antonioli, P., Antusch, S., Anulli, F., Apolinario, L., Apollinari, G., Apollonio, A., Appelo, D., Appleby, R. B., Apyan, Ara., Apyan, Arm., Arbey, A., Arbuzov, A., Arduini, G., Ari, V., Arias, S., Armesto, N., Arnaldi, R., Arsenyev, S. A., Arzeo, M., Asai, S., Aslanides, E., Assmann, R. W., Astapovych, D., Atanasov, M., Atieh, S., Attie, D., Auchmann, B., Audurier, A., Aull, S., Aumon, S., Aune, S., Avino, F., Avrillaud, G., Aydin, G., Azatov, A., Azuelos, G., Azzi, P., Azzolini, O., Azzurri, P., Bacchetta, N., Bacchiocchi, E., Bachacou, H., Baek, Y. W., Baglin, V., Bai, Y., Baird, S., Baker, M. J., Baldwin, M. J., Ball, A. H., Ballarino, A., Banerjee, S., Barber, D. P., Barducci, D., Barjhoux, P., Barna, D., Barnafoldi, G. G., Barnes, M. J., Barr, A., Garcia, J. Barranco, da Costa, J. Barreiro Guimaraes, Bartmann, W., Baryshevsky, V., Barzi, E., Bass, S. A., Bastianin, A., Baudouy, B., Bauer, F., Bauer, M., Baumgartner, T., Bautista-Guzman, I., Bayindir, C., Beaudette, F., Bedeschi, F., Beguin, M., Bellafont, I., Bellagamba, L., Bellegarde, N., Belli, E., Bellingeri, E., Bellini, F., Bellomo, G., Belomestnykh, S., Bencivenni, G., Benedikt, M., Bernardi, G., Bernardi, J., Bernet, C., Bernhardt, J. M., Bernini, C., Berriaud, C., Bertarelli, A., Bertolucci, S., Besana, M. I., Besancon, M., Beznosov, O., Bhat, P., Bhat, C., Biagini, M. E., Biarrotte, J. -L., Chevalier, A. Bibet, Bielert, E. R., Biglietti, M., Bilei, G. M., Bilki, B., Biscari, C., Bishara, F., Blanco-Garcia, O. R., Blanquez, F. R., Blekman, F., Blondel, A., Blumlein, J., Boccali, T., Boels, R., Bogacz, S. A., Bogomyagkov, A., Boine-Frankenheim, O., Boland, M. J., Bologna, S., Bolukbasi, O., Bomben, M., Bondarenko, S., Bonvini, M., Boos, E., Bordini, B., Bordry, F., Borghello, G., Borgonovi, L., Borowka, S., Bortoletto, D., Boscherini, D., Boscolo, M., Boselli, S., Bosley, R. R., Bossu, F., Botta, C., Bottura, L., Boughezal, R., Boutin, D., Bovone, G., Jelisavcic, I. Bozovic, Bozbey, A., Bozzi, C., Bozzini, D., Braccini, V., Braibant-Giacomelli, S., Bramante, J., Braun-Munzinger, P., Briffa, J. A., Britzger, D., Brodsky, S. J., Brooke, J. J., Bruce, R., De Renstrom, P. Bruckman, Bruna, E., Bruning, O., Brunner, O., Brunner, K., Bruzzone, P., Buffat, X., Bulyak, E., Burkart, F., Burkhardt, H., Burnet, J. -P., Butin, F., Buttazzo, D., Butterworth, A., Caccia, M., Cai, Y., Caiffi, B., Cairo, V., Cakir, O., Calaga, R., Calatroni, S., Calderini, G., Calderola, G., Caliskan, A., Calvet, D., Calviani, M., Camalich, J. M., Camarri, P., Campanelli, M., Camporesi, T., Canbay, A. C., Canepa, A., Cantergiani, E., Cantore-Cavalli, D., Capeans, M., Cardarelli, R., Cardella, U., Cardini, A., Calame, C. M. Carloni, Carra, F., Carra, S., Carvalho, A., Casalbuoni, S., Casas, J., Cascella, M., Castelnovo, P., Castorina, G., Catalano, G., Cavasinni, V., Cazzato, E., Cennini, E., Cerri, A., Cerutti, F., Cervantes, J., Chaikovska, I., Chakrabortty, J., Chala, M., Chamizo-Llatas, M., Chanal, H., Chanal, D., Chance, S., Chance, A., Charitos, P., Charles, J., Charles, T. K., Chattopadhyay, S., Chehab, R., Chekanov, S. V., Chen, N., Chernoded, A., Chetvertkova, V., Chevalier, L., Chiarelli, G., Chiarello, G., Chiesa, M., Chiggiato, P., Childers, J. T., Chmielinska, A., Cholakian, A., Chomaz, P., Chorowski, M., Chou, W., Chrzaszcz, M., Chyhyrynets, E., Cibinetto, G., Ciftci, A. K., Ciftci, R., Cimino, R., Ciuchini, M., Clark, P. J., Coadou, Y., Cobal, M., Coccaro, A., Cogan, J., Cogneras, E., Collamati, F., Colldelram, C., Collier, P., Collot, J., Contino, R., Conventi, F., Cook, C. T. A., Cooley, L., Corcella, G., Cornell, A. S., Corral, G. H., Correia-Rodrigues, H., Costanza, F., Pinto, P. Costa, Couderc, F., Coupard, J., Craig, N., Crespo Garrido, I., Crivellin, A., Croteau, J. F., Crouch, M., Alaniz, E. Cruz, Cure, B., Curti, J., Curtin, D., Czech, M., Dachauer, C., D'Agnolo, R. T., Daibo, M., Dainese, A., Dalena, B., Daljevec, A., Dallapiazza, W., Schwartzentruber, L. D'Aloia, Dam, M., D'Ambrosio, G., Das, S. P., DasBakshi, S., da Silva, W., da Silveira, G. G., D'Auria, V., D'Auria, S., David, A., Davidek, T., Deandrea, A., de Blas, J., Debono, C. J., De Curtis, S., De Filippis, N., de Florian, D., Deghaye, S., de Jong, S. J., Bo, C. Del, Duca, V. Del, Delikaris, D., Deliot, F., Dell'Acqua, A., Rose, L. Delle, Delmastro, M., De Lucia, E., Demarteau, M., Denegri, D., Deniau, L., Denisov, D., Denizli, H., Denner, A., d'Enterria, D., de Rijk, G., De Roeck, A., Derue, F., Deschamps, O., Descotes-Genon, S., Dev, P. S. B., de Regie, J. B. de Vivie, Dewanjee, R. K., Ciaccio, A. Di, Cicco, A. Di, Dillon, B. M., Micco, B. Di, Nezza, P. Di, Vita, S. Di, Doblhammer, A., Dominjon, A., D'Onofrio, M., Dordei, F., Drago, A., Draper, P., Drasal, Z., Drewes, M., Duarte, L., Dubovyk, I., Duda, P., Dudarev, A., Dudko, L., Duellmann, D., Duenser, M., du Pree, T., Durante, M., Yildiz, H. Duran, Dutta, S., Duval, F., Duval, J. M., Dydyshka, Ya., Dziewit, B., Eisenhardt, S., Eisterer, M., Ekelof, T., Khechen, D. El, Ellis, S. A., Ellis, J., Ellison, J. A., Elsener, K., Elsing, M., Enari, Y., Englert, C., Eriksson, H., Eskola, K. J., Esposito, L. S., Etisken, O., Etzion, E., Fabbricatore, P., Falkowski, A., Falou, A., Faltova, J., Fan, J., Fano, L., Farilla, A., Farinelli, R., Farinon, S., Faroughy, D. A., Fartoukh, S. D., Faus-Golfe, A., Fawcett, W. J., Felici, G., Felsberger, L., Ferdeghini, C., Fernandez Navarro, A. M., Fernandez-Tellez, A., Troitino, J. Ferradas, Ferrara, G., Ferrari, R., Ferreira, L., da Silva, P. Ferreira, Ferrera, G., Ferro, F., Fiascaris, M., Fiorendi, S., Fiorio, C., Fischer, O., Fischer, E., Flieger, W., Florio, M., Fonnesu, D., Fontanesi, E., Foppiani, N., Foraz, K., Forkel-Wirth, D., Forte, S., Fouaidy, M., Fournier, D., Fowler, T., Fox, J., Francavilla, P., Franceschini, R., Franchino, S., Franco, E., Freitas, A., Fuks, B., Furukawa, K., Furuseth, S. V., Gabrielli, E., Gaddi, A., Galanti, M., Gallo, E., Ganjour, S., Gao, Jia., Gao, Jie., Diaz, V. Garcia, Perez, M. Garcia, Garcia Tabares, L., Garion, C., Garzelli, M. V., Garzia, I., Gascon-Shotkin, S. M., Gaudio, G., Gay, P., Ge, S. -F., Gehrmann, T., Genest, M. H., Gerard, R., Gerigk, F., Gerwig, H., Giacomelli, P., Giagu, S., Gianfelice-Wendt, E., Gianotti, F., Giffoni, F., Gilardoni, S. S., Gil Costa, M., Giovannetti, M., Giovannozzi, M., Giubellino, P., Giudice, G. F., Giunta, A., Gladilin, L. K., Glukhov, S., Gluza, J., Gobbi, G., Goddard, B., Goertz, F., Golling, T., Goncalves, D., Goncalves, V. P., Goncalo, R., Gomez, L. A. Gonzalez, Zadeh, S. Gorgi, Gorine, G., Gorini, E., Gourlay, S. A., Gouskos, L., Grancagnolo, F., Grassellino, A., Grau, A., Graverini, E., Gray, H. M., Greco, Ma., Greco, Mi., Grenard, J. -L., Grimm, O., Grojean, C., Gromov, V. A., Grosse-Oetringhaus, J. F., Grudiev, A., Grzanka, K., Gu, J., Guadagnoli, D., Guidi, V., Guiducci, S., Guillermo Canton, G., Gunaydin, Y. O., Gupta, R., Gupta, R. S., Gutierrez, J., Gutleber, J., Guyot, C., Guzey, V., Gwenlan, C., Haberstroh, Ch., Hacisahinoglu, B., Haerer, B., Hahn, K., Hahn, T., Hammad, A., Han, C., Hance, M., Hannah, A., Harris, P. C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H-J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, Ana., Henriques, And., Hernandez, P., Hernandez-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Hofle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Bermudez, S. Izquierdo, Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jimenez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. O., Karadeniz, H., Karaventzas, V., Karpov, I., Kartal, S., Karyukhin, A., Kashikhin, V., Behr, J. Katharina, Kaya, U., Keintzel, J., Keinz, P. A., Keppel, K., Kersevan, R., Kershaw, K., Khanpour, H., Khatibi, S., Yanehsari, M. Khatiri, Khoze, V. V., Kieseler, J., Kilic, A., Kilpinen, A., Kim, Y. -K., Kim, D. W., Klein, U., Klein, M., Kling, F., Klinkenberg, N., Kloeppel, S., Klute, M., Klyukhin, V. I., Knecht, M., Kniehl, B., Kocak, F., Koeberl, C., Kolano, A. M., Kollegger, A., Kolodziej, K., Kolomiets, A. A., Komppula, J., Koop, I., Koppenburg, P., Koratzinos, M., Kordiaczynska, M., Korjik, M., Kortner, O., Kostka, P., Kotlarski, W., Kotnig, C., Kottig, T., Kotwal, A. V., Kovalenko, A. D., Kowalski, S., Kozaczuk, J., Kozlov, G. A., Kozub, S. S., Krainer, A. M., Kramer, T., Kraemer, M., Krammer, M., Krasnov, A. A., Krauss, F., Kravalis, K., Kretzschmar, L., Kriske, R. M., Kritscher, H., Krkotic, P., Kroha, H., Kucharczyk, M., Kuday, S., Kuendig, A., Kuhlmann, G., Kulesza, A., Kumar, Mi., Kumar, Mu., Kusina, A., Kuttimalai, S., Kuze, M., Kwon, T., Lackner, F., Lackner, M., La Francesca, E., Laine, M., Lamanna, G., La Mendola, S., Lancon, E., Landsberg, G., Langacker, P., Lange, C., Langner, A., Lankford, A. J., Lansberg, J. P., Lari, T., Laycock, P. J., Lebrun, P., Lechner, A., Lee, K., Lee, S., Lee, R., Lefevre, T., Guen, P. Le, Lehtinen, T., Leith, S. B., Lenzi, P., Leogrande, E., Leonidopoulos, C., Leon-Monzon, I., Lerner, G., Leroy, O., Lesiak, T., Levai, P., Leveratto, A., Levichev, E., Li, G., Li, S., Li, R., Liberati, D., Liepe, M., Lissauer, D. A., Liu, Z., Lobko, A., Locci, E., Agaliotis, E. Logothetis, Lombardo, M. P., Long, A. J., Lorin, C., Losito, R., Louzguiti, A., Low, I., Lucchesi, D., Lucchini, M. T., Luciani, A., Lueckhof, M., Lunt, A. J. G., Luzum, M., Lyubimtsev, D. A., Maggiora, M., Magnin, N., Mahmoud, M. A., Mahmoudi, F., Maitre, J., Makarenko, V., Malagoli, A., Malcles, J., Malgeri, L., Mallon, P. J., Maltoni, F., Malvezzi, S., Malyshev, O. B., Mancinelli, G., Mandrik, P., Manfrinetti, P., Mangano, M., Manil, P., Mannelli, M., Marchiori, G., Marhauser, F., Mariani, V., Marinozzi, V., Mariotto, S., Marquard, P., Marquet, C., Marriott-Dodington, T., Martin, R., Martin, O., Martin Camalich, J., Martinez, T., Bruzual, H. Martinez, Martinez-Hernandez, M. I., Martins, D. E., Marzani, S., Marzocca, D., Marzola, L., Masciocchi, S., Masina, I., Massimiliano, A., Massironi, A., Masubuchi, T., Matveev, V. A., Mazzoni, M. A., McCullough, M., McIntosh, P. A., Meade, P., Medina, L., Meier, A., Meignan, J., Mele, B., Mendes Saraiva, J. G., Menez, F., Mentink, M., Meoni, E., Meridiani, P., Merk, M., Mermod, P., Mertens, V., Mether, L., Metral, E., Migliorati, M., Milanese, A., Milardi, C., Milhano, G., Militsyn, B. L., Millet, F., Minashvili, I., Minervini, J. V., Miralles, L. S., Mirarchi, D., Mishima, S., Missiaen, D. P., Mitselmakher, G., Mitsuhashi, T., Mnich, J., Najafabadi, M. Mohammadi, Mohapatra, R. N., Mokhov, N., Molson, J. G., Monge, R., Montag, C., Montagna, G., Monteil, S., Montenero, G., Montesinos, E., Moortgat, F., Morange, N., Morello, G., Llacer, M. Moreno, Moretti, M., Moretti, S., Morley, A. K., Moros, A., Morozov, I., Morretta, V., Morrone, M., Mostacci, A., Muanza, S., Muchnoi, N., Muehlegger, M., Mulder, M., Mulders, M., Mueller, B., Mueller, F., Mueller, A. -S., Munilla, J., Murray, M. J., Muttoni, Y., Myers, S., Mylona, M., Nachtman, J., Nakamoto, T., Nardecchia, M., Nardini, G., Nason, P., Nergiz, Z., Nesterenko, A. V., Nettstraeter, A., Neubuser, C., Neundorf, J., Niccoli, F., Nicrosini, O., Nie, Y., Niedermayer, U., Niedziela, J., Niemi, A., Nikitin, S. A., Nisati, A., No, J. M., Nonis, M., Nosochkov, Y., Novak, M., Novokhatski, A., O'Callaghan, J. M., Ochando, C., Ogur, S., Ohmi, K., Oide, K., Okorokov, V. A., Okumura, Y., Oleari, C., Olness, F. I., Onel, Y., Ortino, M., Osborne, J., Osland, P., Otto, T., Oyulmaz, K. Y., Ozansoy, A., Ozcan, V., Ozdemir, K., Pagliarone, C. E., da Silva, H. F. Pais, Palmieri, E., Palumbo, L., Pampaloni, A., Pan, R. -Q., Panareo, M., Panella, O., Panico, G., Panizzo, G., Pankov, A. A., Pantsyrny, V., Papadopoulos, C. G., Papaefstathiou, A., Papaphilippou, Y., Parker, M. A., Parma, V., Pasquali, M., Patra, S. K., Patterson, R., Paukkunen, H., Pauss, F., Peggs, S., Penttinen, J. -P., Peon, G., Perepelkin, E. E., Perez, E., Perez, J. C., Perez, G., Perez, F., Codina, E. Perez, Perez Morales, J., Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Placzek, W., Plagge, M., Plehn, T., Pleier, M. -A., Ploskon, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Lener, M. Poli, Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Pulawski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramirez-Uribe, N. S., Ramsey-Musolf, M. J., Rata, R., Ratoff, P., Ravotti, F., Rebello Teles, P., Reboud, M., Redaelli, S., Renner, E., Renteria-Olivo, A. E., Rescigno, M., Reuter, J., Ribon, A., Ricci, A. M., Riegler, W., Riemann, S., Riemann, B., Riemann, T., Rifflet, J. M., Rimmer, R. A., Rinaldesi, R., Rinolfi, L., Rubiras, O. Rios, Risselada, T., Rivetti, A., Rivkin, L., Rizzo, T., Robens, T., Robert, F., Robson, A. J., Rochepault, E., Roda, C., Rodrigo, G., Rodriguez-Cahuantzi, M., Rogan, C., Roig, M., Rojas-Torres, S., Rojo, J., Rolandi, G., Rolando, G., Roloff, P., Romanenko, A., Romanov, A., Roncarolo, F., Rosado Sanchez, A., Rosaz, G., Rossi, L., Rossi, A., Rossmanith, R., Rousset, B., Royon, C., Ruan, X., Ruehl, I., Ruhlmann-Kleider, V., Ruiz, R., Rumyantsev, L., Ruprecht, R., Ryazanov, A. I., Saba, A., Sadykov, R., de Jauregui, D. Saez, Sahin, M., Sailer, B., Saito, M., Sala, F., Salam, G. P., Salfeld-Nebgen, J., Salgado, C. A., Salini, S., Sallese, J. M., Salmi, T., Salzburger, A., Sampayo, O. A., Sanfilippo, S., Santiago, J., Santopinto, E., Santoro, R., Ull, A. Sanz, Sarasola, X., Sarpun, I. H., Sauvain, M., Savelyeva, S., Sawada, R., Sborlini, G. F. R., Schaffer, A., Schaumann, M., Schenk, M., Scheuerlein, C., Schienbein, I., Schlenga, K., Schmickler, H., Schmidt, R., Schoerling, D., Schoning, A., Schoerner-Sadenius, T., Schott, M., Schulte, D., Schwaller, P., Schwanenberger, C., Schwemling, P., Schwerg, N., Scibile, L., Sciuto, A., Scomparin, E., Sebastiani, C., Seeber, B., Segreti, M., Selva, P., Selvaggi, M., Senatore, C., Senol, A., Serin, L., Serluca, M., Serra, N., Seryi, A., Sestini, L., Sfyrla, A., Shaposhnikov, M., Shaposhnikova, E., Sharkov, B. Yu., Shatilov, D., Shelton, J., Shiltsev, V., Shipsey, I. P., Shirkov, G. D., Shivaji, A., Shwartz, D., Sian, T., Sidorov, S., Siemko, A., Silvestrini, L., Simand, N., Simon, F., Singh, B. K., Siodmok, A., Sirois, Y., Sirtori, E., Sirvinskaite, R., Sitar, B., Sjoestrand, T., Skands, P., Skordis, E., Skovpen, K., Skrzypek, M., Slade, E., Slavich, P., Slovak, R., Smaluk, V., Smirnov, V., Snoeys, W., Soffi, L., Sollander, P., Solovyanov, O., Soltveit, H. K., Song, H., Sopicki, P., Sorbi, M., Spallino, L., Spannowsky, M., Spataro, B., Sphicas, P., Spiesberger, H., Spiller, P., Spira, M., Srivastava, T., Stachel, J., Stakia, A., Stanyard, J. L., Starchenko, E., Starikov, A. Yu., Stasto, A. M., Statera, M., Steerenberg, R., Steggemann, J., Stenvall, A., Stivanello, F., Stoeckinger, D., Stoel, L. S., Stoeger-Pollach, M., Strauss, B., Stuart, M., Stupakov, G., Su, S., Sublet, A., Sugita, K., Sulak, L., Sullivan, M. K., Sultansoy, S., Sumida, T., Suzuki, K., Sylva, G., Syphers, M. J., Sznajder, A., Taborelli, M., Tahir, N. A., Hod, E. Tal, Takeuchi, M., Tambasco, C., Tanaka, J., Tang, K., Tapan, I., Taroni, S., Tartarelli, G. F., Tassielli, G., Tavian, L., Taylor, T. M., Taylor, G. N., Teixeira, A. M., Tejeda-Munoz, G., Telnov, V. I., Tenchini, R., ten Kate, H. H. J., Terashi, K., Tesi, A., Testa, M., Tetrel, C., Teytelman, D., Thaler, J., Thamm, A., Thomas, S., Tiirakari, M. T., Tikhomirov, V., Tikhonov, D., Timko, H., Tisserand, V., Tkachenko, L. M., Tkaczuk, J., Tock, J. Ph., Todd, B., Todesco, E., Garcia, R. Tomas, Tommasini, D., Tonelli, G., Toral, F., Torims, T., Torre, R., Townsend, Z., Trant, R., Treille, D., Trentadue, L., Tricoli, A., Tricomi, A., Trischuk, W., Tropin, I. S., Tuchming, B., Tudora, A. A., Turbiarz, B., Cakir, I. Turk, Turri, M., Tydecks, T., Usovitsch, J., Uythoven, J., Vaglio, R., Valassi, A., Valchkova, F., Valdivia Garcia, M. A., Valente, P., Valente, R. U., Valente-Feliciano, A. -M., Valentino, G., Silva, L. Vale, Valet, J. M., Valizadeh, R., Valle, J. W. F., Vallecorsa, S., Vallone, G., van Leeuwen, M., van Rienen, U. H., van Riesen-Haupt, L., Varasteh, M., Vecchi, L., Vedrine, P., Velev, G., Veness, R., Ventura, A., Delsolaro, W. Venturini, Verducci, M., Verhaaren, C. B., Vernieri, C., Verweij, A. P., Verwilligen, O., Viazlo, O., Vicini, A., Viehhauser, G., Vignaroli, N., Vignolo, M., Vitrano, A., Vivarelli, I., Vlachos, S., Vogel, M., Vogt, D. M., Voelkl, V., Volkov, P., Volpini, G., von Ahnen, J., Vorotnikov, G., Voutsinas, G. G., Vysotsky, V., Wagner, U., Wallny, R., Wang, L. -T., Wang, R., Wang, K., Ward, B. F. L., Watson, T. P., Watson, N. K., Was, Z., Weiland, C., Weinzierl, S., Welsch, C. P., Wenninger, J., Widorski, M., Wiedemann, U. A., Wienands, H. -U., Wilkinson, G., Williams, P. H., Winter, A., Wohlfahrt, A., Wojton, T., Wollmann, D., Womersley, J., Woog, D., Wu, X., Wulzer, A., Yanehsari, M. K., Yang, G., Yang, H. J., Yao, W. -M., Yazgan, E., Yermolchik, V., Yilmaz, Ay., Yilmaz, Al., Yoo, H. -D., Yost, S. A., You, T., Young, C., Yu, T. -T., Yu, F., Zaborowska, A., Zadeh, S. G., Zahnd, M., Zanetti, M., Zanotto, L., Zawiejski, L., Zeiler, P., Zerlauth, M., Zernov, S. M., Porta, G. Zevi Dell, Zhang, Z., Zhang, Y., Zhang, C., Zhang, H., Zhao, Z., Zhong, Y. -M., Zhou, J., Zhou, D., Zhuang, P., Zick, G., Zimmermann, F., Zinn-Justin, J., Zivkovic, L., Zlobin, A. V., Zobov, M., Zupan, J., and Zurita, J.
Abstract: We review the physics opportunities of the Future Circular Collider, covering its e(+)e(-), pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.
Published: 2019
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30. Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Author: Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, and Kleineidam, Luca
Abstract: Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
Published: 2019

31. Anomalous quartic $WW\gamma\gamma$ couplings in $ep$ collisions at the LHeC and the FCC-he

Author: Ari, V., Gurkanli, E., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., Köksal, M., Ari, V., Gurkanli, E., Gutiérrez-Rodríguez, A., Hernández-Ruíz, M. A., and Köksal, M.
Abstract: We conducted a study on measuring $W^+W^-$ production and on the sensitivity limits at $95\%$ Confidence Level on thirteen anomalous couplings obtained by dimension-8 operators which are related to the anomalous quartic $WW\gamma\gamma$ couplings. We consider the main $e^-p \to e^-\gamma^*\gamma^*p \to e^-W^+W^-p$ reaction with the sub-process $\gamma^*\gamma^* \to W^+W^-$ at the Large Hadron electron Collider (LHeC) and the Future Circular Collider-hadron electron (FCC-he). For the LHeC, energies of the $e^-$ beams are taken to be $E_e =60$ and 140 GeV and the energy of the $p$ beams is taken to be $E_p = 7$ TeV. For the FCC-he, energies of the $e^-$ beams are taken to be $E_e =60$ and 140 GeV and the energy of the $p$ beams is taken to be $E_p = 50$ TeV, respectively. It is interesting to notice that the LHeC and the FCC-he will lead to model-independent limits on the anomalous quartic $WW\gamma\gamma$ couplings which are one order of magnitude stringent than the CMS Collaboration limits, in addition to being competitive with other limits reported in the literature., Comment: 28 pages, 10 Figures and 13 Tables
Published: 2019
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32. Analysis of the anomalous quartic $WWWW$ couplings at the LHeC and the FCC-he

Author: Gurkanli, E., Ari, V., Billur, A. A., Köksal, M., Gurkanli, E., Ari, V., Billur, A. A., and Köksal, M.
Abstract: The quartic gauge boson couplings that identify the strengths of the gauge boson self-interactions are exactly determined by the non-Abelian gauge nature of the Standard Model. The examination of these couplings at $ep$ collisions with high center-of-mass energy and high integrated luminosity provides an important opportunity to test the validity of the Standard Model and the existence of new physics beyond the Standard Model. The quartic gauge boson couplings can contribute directly to multi-boson production at colliders. Therefore, we examine the potential of the process $ep \rightarrow \nu_{e}W^{+}W^{-} j$ at the Large Hadron Electron Collider and the Future Circular Collider-hadron electron to study non-standard $WWWW$ couplings in a model independent way by means of the effective Lagrangian approach. We present an investigation on measuring $W^{+}W^{-}$ production in pure leptonic and semileptonic decay channels. In addition, we calculate the sensitivity limits at $95\%$ Confidence Level on the anomalous $\frac{f_{M0}}{\Lambda^{4}}$, $\frac{f_{M1}}{\Lambda^{4}}$, $\frac{f_{M7}}{\Lambda^{4}}$, $\frac{f_{S0}}{\Lambda^{4}}$, $\frac{f_{S1}}{\Lambda^{4}}$, $\frac{f_{T0}}{\Lambda^{4}}$, $\frac{f_{T1}}{\Lambda^{4}}$ and $\frac{f_{T2}}{\Lambda^{4}}$ couplings obtained by dimension-8 operators through the process $ep \rightarrow \nu_{e}W^{+}W^{-} j$ for the Large Hadron Electron Collider and the Future Circular Hadron Electron Collider's different center-of-mass energies and integrated luminosities. Our results show that with the process $ep \rightarrow \nu_{e}W^{+}W^{-} j$ at the Large Hadron Electron Collider and the Future Circular Collider-hadron electron the sensitivity estimated on the anomalous $WWWW$ couplings can be importantly strengthened., Comment: 33 pages, 9 figures and 25 tables
Published: 2019
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33. Circulating metabolites and the risk of type 2 diabetes:a prospective study of 11,896 young adults from four Finnish cohorts

Author: Ahola-Olli, A. V. (Ari V.), Mustelin, L. (Linda), Kalimeri, M. (Maria), Kettunen, J. (Johannes), Jokelainen, J. (Jari), Auvinen, J. (Juha), Puukka, K. (Katri), Havulinna, A. S. (Aki S.), Lehtimäki, T. (Terho), Kähönen, M. (Mika), Juonala, M. (Markus), Keinänen-Kiukaanniem, S. (Sirkka), Salomaa, V. (Veikko), Perola, M. (Markus), Järvelin, M.-R. (Marjo-Riitta), Ala-Korpela, M. (Mika), Raitakari, O. (Olli), Würtz, P. (Peter), Ahola-Olli, A. V. (Ari V.), Mustelin, L. (Linda), Kalimeri, M. (Maria), Kettunen, J. (Johannes), Jokelainen, J. (Jari), Auvinen, J. (Juha), Puukka, K. (Katri), Havulinna, A. S. (Aki S.), Lehtimäki, T. (Terho), Kähönen, M. (Mika), Juonala, M. (Markus), Keinänen-Kiukaanniem, S. (Sirkka), Salomaa, V. (Veikko), Perola, M. (Markus), Järvelin, M.-R. (Marjo-Riitta), Ala-Korpela, M. (Mika), Raitakari, O. (Olli), and Würtz, P. (Peter)
Abstract: Aims/hypothesis: Metabolomics technologies have identified numerous blood biomarkers for type 2 diabetes risk in case−control studies of middle-aged and older individuals. We aimed to validate existing and identify novel metabolic biomarkers predictive of future diabetes in large cohorts of young adults. Methods: NMR metabolomics was used to quantify 229 circulating metabolic measures in 11,896 individuals from four Finnish observational cohorts (baseline age 24–45 years). Associations between baseline metabolites and risk of developing diabetes during 8–15 years of follow-up (392 incident cases) were adjusted for sex, age, BMI and fasting glucose. Prospective metabolite associations were also tested with fasting glucose, 2 h glucose and HOMA-IR at follow-up. Results: Out of 229 metabolic measures, 113 were associated with incident type 2 diabetes in meta-analysis of the four cohorts (ORs per 1 SD: 0.59–1.50; p< 0.0009). Among the strongest biomarkers of diabetes risk were branched-chain and aromatic amino acids (OR 1.31–1.33) and triacylglycerol within VLDL particles (OR 1.33–1.50), as well as linoleic n-6 fatty acid (OR 0.75) and non-esterified cholesterol in large HDL particles (OR 0.59). The metabolic biomarkers were more strongly associated with deterioration in post-load glucose and insulin resistance than with future fasting hyperglycaemia. A multi-metabolite score comprised of phenylalanine, non-esterified cholesterol in large HDL and the ratio of cholesteryl ester to total lipid in large VLDL was associated with future diabetes risk (OR 10.1 comparing individuals in upper vs lower fifth of the multi-metabolite score) in one of the cohorts (mean age 31 years). Conclusions/interpretation: Metabolic biomarkers across multiple molecular pathways are already predictive of the long-term risk of diabetes in young adults. Comprehensive metabolic profiling may help to target preventive interventions for young asymptomatic individuals at increased risk.
Published: 2019

34. FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1

Author: Abada, A., Abbrescia, M., AbdusSalam, S. S., Abdyukhanov, I., Fernandez, J. Abelleira, Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Fernandez, R. M. Alemany, Alexahin, Y., Alia, R. G., Alioli, S., Tehrani, N. Alipour, Allanach, B. C., Allport, P. P., Altinli, M., Altmannshofer, W., Ambrosio, G., Amorim, D., Amstutz, O., Anderlini, L., Andreazza, A., Andreini, M., Andriatis, A., Andris, C., Andronic, A., Angelucci, M., Antinori, F., Antipov, S. A., Antonelli, M., Antonello, M., Antonioli, P., Antusch, S., Anulli, F., Apolinario, L., Apollinari, G., Apollonio, A., Appelo, D., Appleby, R. B., Apyan, Ara., Apyan, Arm., Arbey, A., Arbuzov, A., Arduini, G., Ari, V., Arias, S., Armesto, N., Arnaldi, R., Arsenyev, S. A., Arzeo, M., Asai, S., Aslanides, E., Assmann, R. W., Astapovych, D., Atanasov, M., Atieh, S., Attie, D., Auchmann, B., Audurier, A., Aull, S., Aumon, S., Aune, S., Avino, F., Avrillaud, G., Aydin, G., Azatov, A., Azuelos, G., Azzi, P., Azzolini, O., Azzurri, P., Bacchetta, N., Bacchiocchi, E., Bachacou, H., Baek, Y. W., Baglin, V., Bai, Y., Baird, S., Baker, M. J., Baldwin, M. J., Ball, A. H., Ballarino, A., Banerjee, S., Barber, D. P., Barducci, D., Barjhoux, P., Barna, D., Barnafoldi, G. G., Barnes, M. J., Barr, A., Garcia, J. Barranco, da Costa, J. Barreiro Guimaraes, Bartmann, W., Baryshevsky, V., Barzi, E., Bass, S. A., Bastianin, A., Baudouy, B., Bauer, F., Bauer, M., Baumgartner, T., Bautista-Guzman, I., Bayindir, C., Beaudette, F., Bedeschi, F., Beguin, M., Bellafont, I., Bellagamba, L., Bellegarde, N., Belli, E., Bellingeri, E., Bellini, F., Bellomo, G., Belomestnykh, S., Bencivenni, G., Benedikt, M., Bernardi, G., Bernardi, J., Bernet, C., Bernhardt, J. M., Bernini, C., Berriaud, C., Bertarelli, A., Bertolucci, S., Besana, M. I., Besancon, M., Beznosov, O., Bhat, P., Bhat, C., Biagini, M. E., Biarrotte, J. -L., Chevalier, A. Bibet, Bielert, E. R., Biglietti, M., Bilei, G. M., Bilki, B., Biscari, C., Bishara, F., Blanco-Garcia, O. R., Blanquez, F. R., Blekman, F., Blondel, A., Blumlein, J., Boccali, T., Boels, R., Bogacz, S. A., Bogomyagkov, A., Boine-Frankenheim, O., Boland, M. J., Bologna, S., Bolukbasi, O., Bomben, M., Bondarenko, S., Bonvini, M., Boos, E., Bordini, B., Bordry, F., Borghello, G., Borgonovi, L., Borowka, S., Bortoletto, D., Boscherini, D., Boscolo, M., Boselli, S., Bosley, R. R., Bossu, F., Botta, C., Bottura, L., Boughezal, R., Boutin, D., Bovone, G., Jelisavcic, I. Bozovic, Bozbey, A., Bozzi, C., Bozzini, D., Braccini, V., Braibant-Giacomelli, S., Bramante, J., Braun-Munzinger, P., Briffa, J. A., Britzger, D., Brodsky, S. J., Brooke, J. J., Bruce, R., De Renstrom, P. Bruckman, Bruna, E., Bruning, O., Brunner, O., Brunner, K., Bruzzone, P., Buffat, X., Bulyak, E., Burkart, F., Burkhardt, H., Burnet, J. -P., Butin, F., Buttazzo, D., Butterworth, A., Caccia, M., Cai, Y., Caiffi, B., Cairo, V., Cakir, O., Calaga, R., Calatroni, S., Calderini, G., Calderola, G., Caliskan, A., Calvet, D., Calviani, M., Camalich, J. M., Camarri, P., Campanelli, M., Camporesi, T., Canbay, A. C., Canepa, A., Cantergiani, E., Cantore-Cavalli, D., Capeans, M., Cardarelli, R., Cardella, U., Cardini, A., Calame, C. M. Carloni, Carra, F., Carra, S., Carvalho, A., Casalbuoni, S., Casas, J., Cascella, M., Castelnovo, P., Castorina, G., Catalano, G., Cavasinni, V., Cazzato, E., Cennini, E., Cerri, A., Cerutti, F., Cervantes, J., Chaikovska, I., Chakrabortty, J., Chala, M., Chamizo-Llatas, M., Chanal, H., Chanal, D., Chance, S., Chance, A., Charitos, P., Charles, J., Charles, T. K., Chattopadhyay, S., Chehab, R., Chekanov, S. V., Chen, N., Chernoded, A., Chetvertkova, V., Chevalier, L., Chiarelli, G., Chiarello, G., Chiesa, M., Chiggiato, P., Childers, J. T., Chmielinska, A., Cholakian, A., Chomaz, P., Chorowski, M., Chou, W., Chrzaszcz, M., Chyhyrynets, E., Cibinetto, G., Ciftci, A. K., Ciftci, R., Cimino, R., Ciuchini, M., Clark, P. J., Coadou, Y., Cobal, M., Coccaro, A., Cogan, J., Cogneras, E., Collamati, F., Colldelram, C., Collier, P., Collot, J., Contino, R., Conventi, F., Cook, C. T. A., Cooley, L., Corcella, G., Cornell, A. S., Corral, G. H., Correia-Rodrigues, H., Costanza, F., Pinto, P. Costa, Couderc, F., Coupard, J., Craig, N., Crespo Garrido, I., Crivellin, A., Croteau, J. F., Crouch, M., Alaniz, E. Cruz, Cure, B., Curti, J., Curtin, D., Czech, M., Dachauer, C., D'Agnolo, R. T., Daibo, M., Dainese, A., Dalena, B., Daljevec, A., Dallapiazza, W., Schwartzentruber, L. D'Aloia, Dam, M., D'Ambrosio, G., Das, S. P., DasBakshi, S., da Silva, W., da Silveira, G. G., D'Auria, V., D'Auria, S., David, A., Davidek, T., Deandrea, A., de Blas, J., Debono, C. J., De Curtis, S., De Filippis, N., de Florian, D., Deghaye, S., de Jong, S. J., Bo, C. Del, Duca, V. Del, Delikaris, D., Deliot, F., Dell'Acqua, A., Rose, L. Delle, Delmastro, M., De Lucia, E., Demarteau, M., Denegri, D., Deniau, L., Denisov, D., Denizli, H., Denner, A., d'Enterria, D., de Rijk, G., De Roeck, A., Derue, F., Deschamps, O., Descotes-Genon, S., Dev, P. S. B., de Regie, J. B. de Vivie, Dewanjee, R. K., Ciaccio, A. Di, Cicco, A. Di, Dillon, B. M., Micco, B. Di, Nezza, P. Di, Vita, S. Di, Doblhammer, A., Dominjon, A., D'Onofrio, M., Dordei, F., Drago, A., Draper, P., Drasal, Z., Drewes, M., Duarte, L., Dubovyk, I., Duda, P., Dudarev, A., Dudko, L., Duellmann, D., Duenser, M., du Pree, T., Durante, M., Yildiz, H. Duran, Dutta, S., Duval, F., Duval, J. M., Dydyshka, Ya., Dziewit, B., Eisenhardt, S., Eisterer, M., Ekelof, T., Khechen, D. El, Ellis, S. A., Ellis, J., Ellison, J. A., Elsener, K., Elsing, M., Enari, Y., Englert, C., Eriksson, H., Eskola, K. J., Esposito, L. S., Etisken, O., Etzion, E., Fabbricatore, P., Falkowski, A., Falou, A., Faltova, J., Fan, J., Fano, L., Farilla, A., Farinelli, R., Farinon, S., Faroughy, D. A., Fartoukh, S. D., Faus-Golfe, A., Fawcett, W. J., Felici, G., Felsberger, L., Ferdeghini, C., Fernandez Navarro, A. M., Fernandez-Tellez, A., Troitino, J. Ferradas, Ferrara, G., Ferrari, R., Ferreira, L., da Silva, P. Ferreira, Ferrera, G., Ferro, F., Fiascaris, M., Fiorendi, S., Fiorio, C., Fischer, O., Fischer, E., Flieger, W., Florio, M., Fonnesu, D., Fontanesi, E., Foppiani, N., Foraz, K., Forkel-Wirth, D., Forte, S., Fouaidy, M., Fournier, D., Fowler, T., Fox, J., Francavilla, P., Franceschini, R., Franchino, S., Franco, E., Freitas, A., Fuks, B., Furukawa, K., Furuseth, S. V., Gabrielli, E., Gaddi, A., Galanti, M., Gallo, E., Ganjour, S., Gao, Jia., Gao, Jie., Diaz, V. Garcia, Perez, M. Garcia, Garcia Tabares, L., Garion, C., Garzelli, M. V., Garzia, I., Gascon-Shotkin, S. M., Gaudio, G., Gay, P., Ge, S. -F., Gehrmann, T., Genest, M. H., Gerard, R., Gerigk, F., Gerwig, H., Giacomelli, P., Giagu, S., Gianfelice-Wendt, E., Gianotti, F., Giffoni, F., Gilardoni, S. S., Gil Costa, M., Giovannetti, M., Giovannozzi, M., Giubellino, P., Giudice, G. F., Giunta, A., Gladilin, L. K., Glukhov, S., Gluza, J., Gobbi, G., Goddard, B., Goertz, F., Golling, T., Goncalves, D., Goncalves, V. P., Goncalo, R., Gomez, L. A. Gonzalez, Zadeh, S. Gorgi, Gorine, G., Gorini, E., Gourlay, S. A., Gouskos, L., Grancagnolo, F., Grassellino, A., Grau, A., Graverini, E., Gray, H. M., Greco, Ma., Greco, Mi., Grenard, J. -L., Grimm, O., Grojean, C., Gromov, V. A., Grosse-Oetringhaus, J. F., Grudiev, A., Grzanka, K., Gu, J., Guadagnoli, D., Guidi, V., Guiducci, S., Guillermo Canton, G., Gunaydin, Y. O., Gupta, R., Gupta, R. S., Gutierrez, J., Gutleber, J., Guyot, C., Guzey, V., Gwenlan, C., Haberstroh, Ch., Hacisahinoglu, B., Haerer, B., Hahn, K., Hahn, T., Hammad, A., Han, C., Hance, M., Hannah, A., Harris, P. C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H-J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, Ana., Henriques, And., Hernandez, P., Hernandez-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Hofle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Bermudez, S. Izquierdo, Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jimenez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. O., Karadeniz, H., Karaventzas, V., Karpov, I., Kartal, S., Karyukhin, A., Kashikhin, V., Behr, J. Katharina, Kaya, U., Keintzel, J., Keinz, P. A., Keppel, K., Kersevan, R., Kershaw, K., Khanpour, H., Khatibi, S., Yanehsari, M. Khatiri, Khoze, V. V., Kieseler, J., Kilic, A., Kilpinen, A., Kim, Y. -K., Kim, D. W., Klein, U., Klein, M., Kling, F., Klinkenberg, N., Kloeppel, S., Klute, M., Klyukhin, V. I., Knecht, M., Kniehl, B., Kocak, F., Koeberl, C., Kolano, A. M., Kollegger, A., Kolodziej, K., Kolomiets, A. A., Komppula, J., Koop, I., Koppenburg, P., Koratzinos, M., Kordiaczynska, M., Korjik, M., Kortner, O., Kostka, P., Kotlarski, W., Kotnig, C., Kottig, T., Kotwal, A. V., Kovalenko, A. D., Kowalski, S., Kozaczuk, J., Kozlov, G. A., Kozub, S. S., Krainer, A. M., Kramer, T., Kraemer, M., Krammer, M., Krasnov, A. A., Krauss, F., Kravalis, K., Kretzschmar, L., Kriske, R. M., Kritscher, H., Krkotic, P., Kroha, H., Kucharczyk, M., Kuday, S., Kuendig, A., Kuhlmann, G., Kulesza, A., Kumar, Mi., Kumar, Mu., Kusina, A., Kuttimalai, S., Kuze, M., Kwon, T., Lackner, F., Lackner, M., La Francesca, E., Laine, M., Lamanna, G., La Mendola, S., Lancon, E., Landsberg, G., Langacker, P., Lange, C., Langner, A., Lankford, A. J., Lansberg, J. P., Lari, T., Laycock, P. J., Lebrun, P., Lechner, A., Lee, K., Lee, S., Lee, R., Lefevre, T., Guen, P. Le, Lehtinen, T., Leith, S. B., Lenzi, P., Leogrande, E., Leonidopoulos, C., Leon-Monzon, I., Lerner, G., Leroy, O., Lesiak, T., Levai, P., Leveratto, A., Levichev, E., Li, G., Li, S., Li, R., Liberati, D., Liepe, M., Lissauer, D. A., Liu, Z., Lobko, A., Locci, E., Agaliotis, E. Logothetis, Lombardo, M. P., Long, A. J., Lorin, C., Losito, R., Louzguiti, A., Low, I., Lucchesi, D., Lucchini, M. T., Luciani, A., Lueckhof, M., Lunt, A. J. G., Luzum, M., Lyubimtsev, D. A., Maggiora, M., Magnin, N., Mahmoud, M. A., Mahmoudi, F., Maitre, J., Makarenko, V., Malagoli, A., Malcles, J., Malgeri, L., Mallon, P. J., Maltoni, F., Malvezzi, S., Malyshev, O. B., Mancinelli, G., Mandrik, P., Manfrinetti, P., Mangano, M., Manil, P., Mannelli, M., Marchiori, G., Marhauser, F., Mariani, V., Marinozzi, V., Mariotto, S., Marquard, P., Marquet, C., Marriott-Dodington, T., Martin, R., Martin, O., Martin Camalich, J., Martinez, T., Bruzual, H. Martinez, Martinez-Hernandez, M. I., Martins, D. E., Marzani, S., Marzocca, D., Marzola, L., Masciocchi, S., Masina, I., Massimiliano, A., Massironi, A., Masubuchi, T., Matveev, V. A., Mazzoni, M. A., McCullough, M., McIntosh, P. A., Meade, P., Medina, L., Meier, A., Meignan, J., Mele, B., Mendes Saraiva, J. G., Menez, F., Mentink, M., Meoni, E., Meridiani, P., Merk, M., Mermod, P., Mertens, V., Mether, L., Metral, E., Migliorati, M., Milanese, A., Milardi, C., Milhano, G., Militsyn, B. L., Millet, F., Minashvili, I., Minervini, J. V., Miralles, L. S., Mirarchi, D., Mishima, S., Missiaen, D. P., Mitselmakher, G., Mitsuhashi, T., Mnich, J., Najafabadi, M. Mohammadi, Mohapatra, R. N., Mokhov, N., Molson, J. G., Monge, R., Montag, C., Montagna, G., Monteil, S., Montenero, G., Montesinos, E., Moortgat, F., Morange, N., Morello, G., Llacer, M. Moreno, Moretti, M., Moretti, S., Morley, A. K., Moros, A., Morozov, I., Morretta, V., Morrone, M., Mostacci, A., Muanza, S., Muchnoi, N., Muehlegger, M., Mulder, M., Mulders, M., Mueller, B., Mueller, F., Mueller, A. -S., Munilla, J., Murray, M. J., Muttoni, Y., Myers, S., Mylona, M., Nachtman, J., Nakamoto, T., Nardecchia, M., Nardini, G., Nason, P., Nergiz, Z., Nesterenko, A. V., Nettstraeter, A., Neubuser, C., Neundorf, J., Niccoli, F., Nicrosini, O., Nie, Y., Niedermayer, U., Niedziela, J., Niemi, A., Nikitin, S. A., Nisati, A., No, J. M., Nonis, M., Nosochkov, Y., Novak, M., Novokhatski, A., O'Callaghan, J. M., Ochando, C., Ogur, S., Ohmi, K., Oide, K., Okorokov, V. A., Okumura, Y., Oleari, C., Olness, F. I., Onel, Y., Ortino, M., Osborne, J., Osland, P., Otto, T., Oyulmaz, K. Y., Ozansoy, A., Ozcan, V., Ozdemir, K., Pagliarone, C. E., da Silva, H. F. Pais, Palmieri, E., Palumbo, L., Pampaloni, A., Pan, R. -Q., Panareo, M., Panella, O., Panico, G., Panizzo, G., Pankov, A. A., Pantsyrny, V., Papadopoulos, C. G., Papaefstathiou, A., Papaphilippou, Y., Parker, M. A., Parma, V., Pasquali, M., Patra, S. K., Patterson, R., Paukkunen, H., Pauss, F., Peggs, S., Penttinen, J. -P., Peon, G., Perepelkin, E. E., Perez, E., Perez, J. C., Perez, G., Perez, F., Codina, E. Perez, Perez Morales, J., Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Placzek, W., Plagge, M., Plehn, T., Pleier, M. -A., Ploskon, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Lener, M. Poli, Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Pulawski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramirez-Uribe, N. S., Ramsey-Musolf, M. J., Rata, R., Ratoff, P., Ravotti, F., Rebello Teles, P., Reboud, M., Redaelli, S., Renner, E., Renteria-Olivo, A. E., Rescigno, M., Reuter, J., Ribon, A., Ricci, A. M., Riegler, W., Riemann, S., Riemann, B., Riemann, T., Rifflet, J. M., Rimmer, R. A., Rinaldesi, R., Rinolfi, L., Rubiras, O. Rios, Risselada, T., Rivetti, A., Rivkin, L., Rizzo, T., Robens, T., Robert, F., Robson, A. J., Rochepault, E., Roda, C., Rodrigo, G., Rodriguez-Cahuantzi, M., Rogan, C., Roig, M., Rojas-Torres, S., Rojo, J., Rolandi, G., Rolando, G., Roloff, P., Romanenko, A., Romanov, A., Roncarolo, F., Rosado Sanchez, A., Rosaz, G., Rossi, L., Rossi, A., Rossmanith, R., Rousset, B., Royon, C., Ruan, X., Ruehl, I., Ruhlmann-Kleider, V., Ruiz, R., Rumyantsev, L., Ruprecht, R., Ryazanov, A. I., Saba, A., Sadykov, R., de Jauregui, D. Saez, Sahin, M., Sailer, B., Saito, M., Sala, F., Salam, G. P., Salfeld-Nebgen, J., Salgado, C. A., Salini, S., Sallese, J. M., Salmi, T., Salzburger, A., Sampayo, O. A., Sanfilippo, S., Santiago, J., Santopinto, E., Santoro, R., Ull, A. Sanz, Sarasola, X., Sarpun, I. H., Sauvain, M., Savelyeva, S., Sawada, R., Sborlini, G. F. R., Schaffer, A., Schaumann, M., Schenk, M., Scheuerlein, C., Schienbein, I., Schlenga, K., Schmickler, H., Schmidt, R., Schoerling, D., Schoning, A., Schoerner-Sadenius, T., Schott, M., Schulte, D., Schwaller, P., Schwanenberger, C., Schwemling, P., Schwerg, N., Scibile, L., Sciuto, A., Scomparin, E., Sebastiani, C., Seeber, B., Segreti, M., Selva, P., Selvaggi, M., Senatore, C., Senol, A., Serin, L., Serluca, M., Serra, N., Seryi, A., Sestini, L., Sfyrla, A., Shaposhnikov, M., Shaposhnikova, E., Sharkov, B. Yu., Shatilov, D., Shelton, J., Shiltsev, V., Shipsey, I. P., Shirkov, G. D., Shivaji, A., Shwartz, D., Sian, T., Sidorov, S., Siemko, A., Silvestrini, L., Simand, N., Simon, F., Singh, B. K., Siodmok, A., Sirois, Y., Sirtori, E., Sirvinskaite, R., Sitar, B., Sjoestrand, T., Skands, P., Skordis, E., Skovpen, K., Skrzypek, M., Slade, E., Slavich, P., Slovak, R., Smaluk, V., Smirnov, V., Snoeys, W., Soffi, L., Sollander, P., Solovyanov, O., Soltveit, H. K., Song, H., Sopicki, P., Sorbi, M., Spallino, L., Spannowsky, M., Spataro, B., Sphicas, P., Spiesberger, H., Spiller, P., Spira, M., Srivastava, T., Stachel, J., Stakia, A., Stanyard, J. L., Starchenko, E., Starikov, A. Yu., Stasto, A. M., Statera, M., Steerenberg, R., Steggemann, J., Stenvall, A., Stivanello, F., Stoeckinger, D., Stoel, L. S., Stoeger-Pollach, M., Strauss, B., Stuart, M., Stupakov, G., Su, S., Sublet, A., Sugita, K., Sulak, L., Sullivan, M. K., Sultansoy, S., Sumida, T., Suzuki, K., Sylva, G., Syphers, M. J., Sznajder, A., Taborelli, M., Tahir, N. A., Hod, E. Tal, Takeuchi, M., Tambasco, C., Tanaka, J., Tang, K., Tapan, I., Taroni, S., Tartarelli, G. F., Tassielli, G., Tavian, L., Taylor, T. M., Taylor, G. N., Teixeira, A. M., Tejeda-Munoz, G., Telnov, V. I., Tenchini, R., ten Kate, H. H. J., Terashi, K., Tesi, A., Testa, M., Tetrel, C., Teytelman, D., Thaler, J., Thamm, A., Thomas, S., Tiirakari, M. T., Tikhomirov, V., Tikhonov, D., Timko, H., Tisserand, V., Tkachenko, L. M., Tkaczuk, J., Tock, J. Ph., Todd, B., Todesco, E., Garcia, R. Tomas, Tommasini, D., Tonelli, G., Toral, F., Torims, T., Torre, R., Townsend, Z., Trant, R., Treille, D., Trentadue, L., Tricoli, A., Tricomi, A., Trischuk, W., Tropin, I. S., Tuchming, B., Tudora, A. A., Turbiarz, B., Cakir, I. Turk, Turri, M., Tydecks, T., Usovitsch, J., Uythoven, J., Vaglio, R., Valassi, A., Valchkova, F., Valdivia Garcia, M. A., Valente, P., Valente, R. U., Valente-Feliciano, A. -M., Valentino, G., Silva, L. Vale, Valet, J. M., Valizadeh, R., Valle, J. W. F., Vallecorsa, S., Vallone, G., van Leeuwen, M., van Rienen, U. H., van Riesen-Haupt, L., Varasteh, M., Vecchi, L., Vedrine, P., Velev, G., Veness, R., Ventura, A., Delsolaro, W. Venturini, Verducci, M., Verhaaren, C. B., Vernieri, C., Verweij, A. P., Verwilligen, O., Viazlo, O., Vicini, A., Viehhauser, G., Vignaroli, N., Vignolo, M., Vitrano, A., Vivarelli, I., Vlachos, S., Vogel, M., Vogt, D. M., Voelkl, V., Volkov, P., Volpini, G., von Ahnen, J., Vorotnikov, G., Voutsinas, G. G., Vysotsky, V., Wagner, U., Wallny, R., Wang, L. -T., Wang, R., Wang, K., Ward, B. F. L., Watson, T. P., Watson, N. K., Was, Z., Weiland, C., Weinzierl, S., Welsch, C. P., Wenninger, J., Widorski, M., Wiedemann, U. A., Wienands, H. -U., Wilkinson, G., Williams, P. H., Winter, A., Wohlfahrt, A., Wojton, T., Wollmann, D., Womersley, J., Woog, D., Wu, X., Wulzer, A., Yanehsari, M. K., Yang, G., Yang, H. J., Yao, W. -M., Yazgan, E., Yermolchik, V., Yilmaz, Ay., Yilmaz, Al., Yoo, H. -D., Yost, S. A., You, T., Young, C., Yu, T. -T., Yu, F., Zaborowska, A., Zadeh, S. G., Zahnd, M., Zanetti, M., Zanotto, L., Zawiejski, L., Zeiler, P., Zerlauth, M., Zernov, S. M., Porta, G. Zevi Dell, Zhang, Z., Zhang, Y., Zhang, C., Zhang, H., Zhao, Z., Zhong, Y. -M., Zhou, J., Zhou, D., Zhuang, P., Zick, G., Zimmermann, F., Zinn-Justin, J., Zivkovic, L., Zlobin, A. V., Zobov, M., Zupan, J., Zurita, J., Abada, A., Abbrescia, M., AbdusSalam, S. S., Abdyukhanov, I., Fernandez, J. Abelleira, Abramov, A., Aburaia, M., Acar, A. O., Adzic, P. R., Agrawal, P., Aguilar-Saavedra, J. A., Aguilera-Verdugo, J. J., Aiba, M., Aichinger, I., Aielli, G., Akay, A., Akhundov, A., Aksakal, H., Albacete, J. L., Albergo, S., Alekou, A., Aleksa, M., Aleksan, R., Fernandez, R. M. Alemany, Alexahin, Y., Alia, R. G., Alioli, S., Tehrani, N. Alipour, Allanach, B. C., Allport, P. P., Altinli, M., Altmannshofer, W., Ambrosio, G., Amorim, D., Amstutz, O., Anderlini, L., Andreazza, A., Andreini, M., Andriatis, A., Andris, C., Andronic, A., Angelucci, M., Antinori, F., Antipov, S. A., Antonelli, M., Antonello, M., Antonioli, P., Antusch, S., Anulli, F., Apolinario, L., Apollinari, G., Apollonio, A., Appelo, D., Appleby, R. B., Apyan, Ara., Apyan, Arm., Arbey, A., Arbuzov, A., Arduini, G., Ari, V., Arias, S., Armesto, N., Arnaldi, R., Arsenyev, S. A., Arzeo, M., Asai, S., Aslanides, E., Assmann, R. W., Astapovych, D., Atanasov, M., Atieh, S., Attie, D., Auchmann, B., Audurier, A., Aull, S., Aumon, S., Aune, S., Avino, F., Avrillaud, G., Aydin, G., Azatov, A., Azuelos, G., Azzi, P., Azzolini, O., Azzurri, P., Bacchetta, N., Bacchiocchi, E., Bachacou, H., Baek, Y. W., Baglin, V., Bai, Y., Baird, S., Baker, M. J., Baldwin, M. J., Ball, A. H., Ballarino, A., Banerjee, S., Barber, D. P., Barducci, D., Barjhoux, P., Barna, D., Barnafoldi, G. G., Barnes, M. J., Barr, A., Garcia, J. Barranco, da Costa, J. Barreiro Guimaraes, Bartmann, W., Baryshevsky, V., Barzi, E., Bass, S. A., Bastianin, A., Baudouy, B., Bauer, F., Bauer, M., Baumgartner, T., Bautista-Guzman, I., Bayindir, C., Beaudette, F., Bedeschi, F., Beguin, M., Bellafont, I., Bellagamba, L., Bellegarde, N., Belli, E., Bellingeri, E., Bellini, F., Bellomo, G., Belomestnykh, S., Bencivenni, G., Benedikt, M., Bernardi, G., Bernardi, J., Bernet, C., Bernhardt, J. M., Bernini, C., Berriaud, C., Bertarelli, A., Bertolucci, S., Besana, M. I., Besancon, M., Beznosov, O., Bhat, P., Bhat, C., Biagini, M. E., Biarrotte, J. -L., Chevalier, A. Bibet, Bielert, E. R., Biglietti, M., Bilei, G. M., Bilki, B., Biscari, C., Bishara, F., Blanco-Garcia, O. R., Blanquez, F. R., Blekman, F., Blondel, A., Blumlein, J., Boccali, T., Boels, R., Bogacz, S. A., Bogomyagkov, A., Boine-Frankenheim, O., Boland, M. J., Bologna, S., Bolukbasi, O., Bomben, M., Bondarenko, S., Bonvini, M., Boos, E., Bordini, B., Bordry, F., Borghello, G., Borgonovi, L., Borowka, S., Bortoletto, D., Boscherini, D., Boscolo, M., Boselli, S., Bosley, R. R., Bossu, F., Botta, C., Bottura, L., Boughezal, R., Boutin, D., Bovone, G., Jelisavcic, I. Bozovic, Bozbey, A., Bozzi, C., Bozzini, D., Braccini, V., Braibant-Giacomelli, S., Bramante, J., Braun-Munzinger, P., Briffa, J. A., Britzger, D., Brodsky, S. J., Brooke, J. J., Bruce, R., De Renstrom, P. Bruckman, Bruna, E., Bruning, O., Brunner, O., Brunner, K., Bruzzone, P., Buffat, X., Bulyak, E., Burkart, F., Burkhardt, H., Burnet, J. -P., Butin, F., Buttazzo, D., Butterworth, A., Caccia, M., Cai, Y., Caiffi, B., Cairo, V., Cakir, O., Calaga, R., Calatroni, S., Calderini, G., Calderola, G., Caliskan, A., Calvet, D., Calviani, M., Camalich, J. M., Camarri, P., Campanelli, M., Camporesi, T., Canbay, A. C., Canepa, A., Cantergiani, E., Cantore-Cavalli, D., Capeans, M., Cardarelli, R., Cardella, U., Cardini, A., Calame, C. M. Carloni, Carra, F., Carra, S., Carvalho, A., Casalbuoni, S., Casas, J., Cascella, M., Castelnovo, P., Castorina, G., Catalano, G., Cavasinni, V., Cazzato, E., Cennini, E., Cerri, A., Cerutti, F., Cervantes, J., Chaikovska, I., Chakrabortty, J., Chala, M., Chamizo-Llatas, M., Chanal, H., Chanal, D., Chance, S., Chance, A., Charitos, P., Charles, J., Charles, T. K., Chattopadhyay, S., Chehab, R., Chekanov, S. V., Chen, N., Chernoded, A., Chetvertkova, V., Chevalier, L., Chiarelli, G., Chiarello, G., Chiesa, M., Chiggiato, P., Childers, J. T., Chmielinska, A., Cholakian, A., Chomaz, P., Chorowski, M., Chou, W., Chrzaszcz, M., Chyhyrynets, E., Cibinetto, G., Ciftci, A. K., Ciftci, R., Cimino, R., Ciuchini, M., Clark, P. J., Coadou, Y., Cobal, M., Coccaro, A., Cogan, J., Cogneras, E., Collamati, F., Colldelram, C., Collier, P., Collot, J., Contino, R., Conventi, F., Cook, C. T. A., Cooley, L., Corcella, G., Cornell, A. S., Corral, G. H., Correia-Rodrigues, H., Costanza, F., Pinto, P. Costa, Couderc, F., Coupard, J., Craig, N., Crespo Garrido, I., Crivellin, A., Croteau, J. F., Crouch, M., Alaniz, E. Cruz, Cure, B., Curti, J., Curtin, D., Czech, M., Dachauer, C., D'Agnolo, R. T., Daibo, M., Dainese, A., Dalena, B., Daljevec, A., Dallapiazza, W., Schwartzentruber, L. D'Aloia, Dam, M., D'Ambrosio, G., Das, S. P., DasBakshi, S., da Silva, W., da Silveira, G. G., D'Auria, V., D'Auria, S., David, A., Davidek, T., Deandrea, A., de Blas, J., Debono, C. J., De Curtis, S., De Filippis, N., de Florian, D., Deghaye, S., de Jong, S. J., Bo, C. Del, Duca, V. Del, Delikaris, D., Deliot, F., Dell'Acqua, A., Rose, L. Delle, Delmastro, M., De Lucia, E., Demarteau, M., Denegri, D., Deniau, L., Denisov, D., Denizli, H., Denner, A., d'Enterria, D., de Rijk, G., De Roeck, A., Derue, F., Deschamps, O., Descotes-Genon, S., Dev, P. S. B., de Regie, J. B. de Vivie, Dewanjee, R. K., Ciaccio, A. Di, Cicco, A. Di, Dillon, B. M., Micco, B. Di, Nezza, P. Di, Vita, S. Di, Doblhammer, A., Dominjon, A., D'Onofrio, M., Dordei, F., Drago, A., Draper, P., Drasal, Z., Drewes, M., Duarte, L., Dubovyk, I., Duda, P., Dudarev, A., Dudko, L., Duellmann, D., Duenser, M., du Pree, T., Durante, M., Yildiz, H. Duran, Dutta, S., Duval, F., Duval, J. M., Dydyshka, Ya., Dziewit, B., Eisenhardt, S., Eisterer, M., Ekelof, T., Khechen, D. El, Ellis, S. A., Ellis, J., Ellison, J. A., Elsener, K., Elsing, M., Enari, Y., Englert, C., Eriksson, H., Eskola, K. J., Esposito, L. S., Etisken, O., Etzion, E., Fabbricatore, P., Falkowski, A., Falou, A., Faltova, J., Fan, J., Fano, L., Farilla, A., Farinelli, R., Farinon, S., Faroughy, D. A., Fartoukh, S. D., Faus-Golfe, A., Fawcett, W. J., Felici, G., Felsberger, L., Ferdeghini, C., Fernandez Navarro, A. M., Fernandez-Tellez, A., Troitino, J. Ferradas, Ferrara, G., Ferrari, R., Ferreira, L., da Silva, P. Ferreira, Ferrera, G., Ferro, F., Fiascaris, M., Fiorendi, S., Fiorio, C., Fischer, O., Fischer, E., Flieger, W., Florio, M., Fonnesu, D., Fontanesi, E., Foppiani, N., Foraz, K., Forkel-Wirth, D., Forte, S., Fouaidy, M., Fournier, D., Fowler, T., Fox, J., Francavilla, P., Franceschini, R., Franchino, S., Franco, E., Freitas, A., Fuks, B., Furukawa, K., Furuseth, S. V., Gabrielli, E., Gaddi, A., Galanti, M., Gallo, E., Ganjour, S., Gao, Jia., Gao, Jie., Diaz, V. Garcia, Perez, M. Garcia, Garcia Tabares, L., Garion, C., Garzelli, M. V., Garzia, I., Gascon-Shotkin, S. M., Gaudio, G., Gay, P., Ge, S. -F., Gehrmann, T., Genest, M. H., Gerard, R., Gerigk, F., Gerwig, H., Giacomelli, P., Giagu, S., Gianfelice-Wendt, E., Gianotti, F., Giffoni, F., Gilardoni, S. S., Gil Costa, M., Giovannetti, M., Giovannozzi, M., Giubellino, P., Giudice, G. F., Giunta, A., Gladilin, L. K., Glukhov, S., Gluza, J., Gobbi, G., Goddard, B., Goertz, F., Golling, T., Goncalves, D., Goncalves, V. P., Goncalo, R., Gomez, L. A. Gonzalez, Zadeh, S. Gorgi, Gorine, G., Gorini, E., Gourlay, S. A., Gouskos, L., Grancagnolo, F., Grassellino, A., Grau, A., Graverini, E., Gray, H. M., Greco, Ma., Greco, Mi., Grenard, J. -L., Grimm, O., Grojean, C., Gromov, V. A., Grosse-Oetringhaus, J. F., Grudiev, A., Grzanka, K., Gu, J., Guadagnoli, D., Guidi, V., Guiducci, S., Guillermo Canton, G., Gunaydin, Y. O., Gupta, R., Gupta, R. S., Gutierrez, J., Gutleber, J., Guyot, C., Guzey, V., Gwenlan, C., Haberstroh, Ch., Hacisahinoglu, B., Haerer, B., Hahn, K., Hahn, T., Hammad, A., Han, C., Hance, M., Hannah, A., Harris, P. C., Hati, C., Haug, S., Hauptman, J., Haurylavets, V., He, H-J., Hegglin, A., Hegner, B., Heinemann, K., Heinemeyer, S., Helsens, C., Henriques, Ana., Henriques, And., Hernandez, P., Hernandez-Pinto, R. J., Hernandez-Sanchez, J., Herzig, T., Hiekkanen, I., Hillert, W., Hoehn, T., Hofer, M., Hofle, W., Holdener, F., Holleis, S., Holzer, B., Hong, D. K., Honorato, C. G., Hopkins, S. C., Hrdinka, J., Hug, F., Humann, B., Humer, H., Hurth, T., Hutton, A., Iacobucci, G., Ibarrola, N., Iconomidou-Fayard, L., Ilyina-Brunner, K., Incandela, J., Infantino, A., Ippolito, V., Ishino, M., Islam, R., Ita, H., Ivanovs, A., Iwamoto, S., Iyer, A., Bermudez, S. Izquierdo, Jadach, S., Jamin, D. O., Janot, P., Jarry, P., Jeff, A., Jenny, P., Jensen, E., Jensen, M., Jiang, X., Jimenez, J. M., Jones, M. A., Jones, O. R., Jowett, J. M., Jung, S., Kaabi, W., Kado, M., Kahle, K., Kalinovskaya, L., Kalinowski, J., Kamenik, J. F., Kannike, K., Kara, S. O., Karadeniz, H., Karaventzas, V., Karpov, I., Kartal, S., Karyukhin, A., Kashikhin, V., Behr, J. Katharina, Kaya, U., Keintzel, J., Keinz, P. A., Keppel, K., Kersevan, R., Kershaw, K., Khanpour, H., Khatibi, S., Yanehsari, M. Khatiri, Khoze, V. V., Kieseler, J., Kilic, A., Kilpinen, A., Kim, Y. -K., Kim, D. W., Klein, U., Klein, M., Kling, F., Klinkenberg, N., Kloeppel, S., Klute, M., Klyukhin, V. I., Knecht, M., Kniehl, B., Kocak, F., Koeberl, C., Kolano, A. M., Kollegger, A., Kolodziej, K., Kolomiets, A. A., Komppula, J., Koop, I., Koppenburg, P., Koratzinos, M., Kordiaczynska, M., Korjik, M., Kortner, O., Kostka, P., Kotlarski, W., Kotnig, C., Kottig, T., Kotwal, A. V., Kovalenko, A. D., Kowalski, S., Kozaczuk, J., Kozlov, G. A., Kozub, S. S., Krainer, A. M., Kramer, T., Kraemer, M., Krammer, M., Krasnov, A. A., Krauss, F., Kravalis, K., Kretzschmar, L., Kriske, R. M., Kritscher, H., Krkotic, P., Kroha, H., Kucharczyk, M., Kuday, S., Kuendig, A., Kuhlmann, G., Kulesza, A., Kumar, Mi., Kumar, Mu., Kusina, A., Kuttimalai, S., Kuze, M., Kwon, T., Lackner, F., Lackner, M., La Francesca, E., Laine, M., Lamanna, G., La Mendola, S., Lancon, E., Landsberg, G., Langacker, P., Lange, C., Langner, A., Lankford, A. J., Lansberg, J. P., Lari, T., Laycock, P. J., Lebrun, P., Lechner, A., Lee, K., Lee, S., Lee, R., Lefevre, T., Guen, P. Le, Lehtinen, T., Leith, S. B., Lenzi, P., Leogrande, E., Leonidopoulos, C., Leon-Monzon, I., Lerner, G., Leroy, O., Lesiak, T., Levai, P., Leveratto, A., Levichev, E., Li, G., Li, S., Li, R., Liberati, D., Liepe, M., Lissauer, D. A., Liu, Z., Lobko, A., Locci, E., Agaliotis, E. Logothetis, Lombardo, M. P., Long, A. J., Lorin, C., Losito, R., Louzguiti, A., Low, I., Lucchesi, D., Lucchini, M. T., Luciani, A., Lueckhof, M., Lunt, A. J. G., Luzum, M., Lyubimtsev, D. A., Maggiora, M., Magnin, N., Mahmoud, M. A., Mahmoudi, F., Maitre, J., Makarenko, V., Malagoli, A., Malcles, J., Malgeri, L., Mallon, P. J., Maltoni, F., Malvezzi, S., Malyshev, O. B., Mancinelli, G., Mandrik, P., Manfrinetti, P., Mangano, M., Manil, P., Mannelli, M., Marchiori, G., Marhauser, F., Mariani, V., Marinozzi, V., Mariotto, S., Marquard, P., Marquet, C., Marriott-Dodington, T., Martin, R., Martin, O., Martin Camalich, J., Martinez, T., Bruzual, H. Martinez, Martinez-Hernandez, M. I., Martins, D. E., Marzani, S., Marzocca, D., Marzola, L., Masciocchi, S., Masina, I., Massimiliano, A., Massironi, A., Masubuchi, T., Matveev, V. A., Mazzoni, M. A., McCullough, M., McIntosh, P. A., Meade, P., Medina, L., Meier, A., Meignan, J., Mele, B., Mendes Saraiva, J. G., Menez, F., Mentink, M., Meoni, E., Meridiani, P., Merk, M., Mermod, P., Mertens, V., Mether, L., Metral, E., Migliorati, M., Milanese, A., Milardi, C., Milhano, G., Militsyn, B. L., Millet, F., Minashvili, I., Minervini, J. V., Miralles, L. S., Mirarchi, D., Mishima, S., Missiaen, D. P., Mitselmakher, G., Mitsuhashi, T., Mnich, J., Najafabadi, M. Mohammadi, Mohapatra, R. N., Mokhov, N., Molson, J. G., Monge, R., Montag, C., Montagna, G., Monteil, S., Montenero, G., Montesinos, E., Moortgat, F., Morange, N., Morello, G., Llacer, M. Moreno, Moretti, M., Moretti, S., Morley, A. K., Moros, A., Morozov, I., Morretta, V., Morrone, M., Mostacci, A., Muanza, S., Muchnoi, N., Muehlegger, M., Mulder, M., Mulders, M., Mueller, B., Mueller, F., Mueller, A. -S., Munilla, J., Murray, M. J., Muttoni, Y., Myers, S., Mylona, M., Nachtman, J., Nakamoto, T., Nardecchia, M., Nardini, G., Nason, P., Nergiz, Z., Nesterenko, A. V., Nettstraeter, A., Neubuser, C., Neundorf, J., Niccoli, F., Nicrosini, O., Nie, Y., Niedermayer, U., Niedziela, J., Niemi, A., Nikitin, S. A., Nisati, A., No, J. M., Nonis, M., Nosochkov, Y., Novak, M., Novokhatski, A., O'Callaghan, J. M., Ochando, C., Ogur, S., Ohmi, K., Oide, K., Okorokov, V. A., Okumura, Y., Oleari, C., Olness, F. I., Onel, Y., Ortino, M., Osborne, J., Osland, P., Otto, T., Oyulmaz, K. Y., Ozansoy, A., Ozcan, V., Ozdemir, K., Pagliarone, C. E., da Silva, H. F. Pais, Palmieri, E., Palumbo, L., Pampaloni, A., Pan, R. -Q., Panareo, M., Panella, O., Panico, G., Panizzo, G., Pankov, A. A., Pantsyrny, V., Papadopoulos, C. G., Papaefstathiou, A., Papaphilippou, Y., Parker, M. A., Parma, V., Pasquali, M., Patra, S. K., Patterson, R., Paukkunen, H., Pauss, F., Peggs, S., Penttinen, J. -P., Peon, G., Perepelkin, E. E., Perez, E., Perez, J. C., Perez, G., Perez, F., Codina, E. Perez, Perez Morales, J., Perfilov, M., Pernegger, H., Peruzzi, M., Pes, C., Peters, K., Petracca, S., Petriello, F., Pezzotti, L., Pfeiffer, S., Piccinini, F., Pieloni, T., Pierini, M., Pikhartova, H., Pikurs, G., Pilicer, E., Piminov, P., Pira, C., Pittau, R., Placzek, W., Plagge, M., Plehn, T., Pleier, M. -A., Ploskon, M., Podeur, M., Podlech, H., Podzorny, T., Poggioli, L., Poiron, A., Polesello, G., Lener, M. Poli, Polini, A., Polinski, J., Polozov, S. M., Ponce, L., Pont, M., Pontecorvo, L., Portaluri, T., Potamianos, K., Prasse, C., Prausa, M., Preinerstorfer, A., Premat, E., Price, T., Primavera, M., Prino, F., Prioli, M., Proudfoot, J., Provino, A., Pugnat, T., Pukhaeva, N., Pulawski, S., Pulikowski, D., Punzi, G., Putti, M., Pyarelal, A., Quack, H., Quispe, M., Racioppi, A., Rafique, H., Raginel, V., Raidal, M., Ramirez-Uribe, N. S., Ramsey-Musolf, M. J., Rata, R., Ratoff, P., Ravotti, F., Rebello Teles, P., Reboud, M., Redaelli, S., Renner, E., Renteria-Olivo, A. E., Rescigno, M., Reuter, J., Ribon, A., Ricci, A. M., Riegler, W., Riemann, S., Riemann, B., Riemann, T., Rifflet, J. M., Rimmer, R. A., Rinaldesi, R., Rinolfi, L., Rubiras, O. Rios, Risselada, T., Rivetti, A., Rivkin, L., Rizzo, T., Robens, T., Robert, F., Robson, A. J., Rochepault, E., Roda, C., Rodrigo, G., Rodriguez-Cahuantzi, M., Rogan, C., Roig, M., Rojas-Torres, S., Rojo, J., Rolandi, G., Rolando, G., Roloff, P., Romanenko, A., Romanov, A., Roncarolo, F., Rosado Sanchez, A., Rosaz, G., Rossi, L., Rossi, A., Rossmanith, R., Rousset, B., Royon, C., Ruan, X., Ruehl, I., Ruhlmann-Kleider, V., Ruiz, R., Rumyantsev, L., Ruprecht, R., Ryazanov, A. I., Saba, A., Sadykov, R., de Jauregui, D. Saez, Sahin, M., Sailer, B., Saito, M., Sala, F., Salam, G. P., Salfeld-Nebgen, J., Salgado, C. A., Salini, S., Sallese, J. M., Salmi, T., Salzburger, A., Sampayo, O. A., Sanfilippo, S., Santiago, J., Santopinto, E., Santoro, R., Ull, A. Sanz, Sarasola, X., Sarpun, I. H., Sauvain, M., Savelyeva, S., Sawada, R., Sborlini, G. F. R., Schaffer, A., Schaumann, M., Schenk, M., Scheuerlein, C., Schienbein, I., Schlenga, K., Schmickler, H., Schmidt, R., Schoerling, D., Schoning, A., Schoerner-Sadenius, T., Schott, M., Schulte, D., Schwaller, P., Schwanenberger, C., Schwemling, P., Schwerg, N., Scibile, L., Sciuto, A., Scomparin, E., Sebastiani, C., Seeber, B., Segreti, M., Selva, P., Selvaggi, M., Senatore, C., Senol, A., Serin, L., Serluca, M., Serra, N., Seryi, A., Sestini, L., Sfyrla, A., Shaposhnikov, M., Shaposhnikova, E., Sharkov, B. Yu., Shatilov, D., Shelton, J., Shiltsev, V., Shipsey, I. P., Shirkov, G. D., Shivaji, A., Shwartz, D., Sian, T., Sidorov, S., Siemko, A., Silvestrini, L., Simand, N., Simon, F., Singh, B. K., Siodmok, A., Sirois, Y., Sirtori, E., Sirvinskaite, R., Sitar, B., Sjoestrand, T., Skands, P., Skordis, E., Skovpen, K., Skrzypek, M., Slade, E., Slavich, P., Slovak, R., Smaluk, V., Smirnov, V., Snoeys, W., Soffi, L., Sollander, P., Solovyanov, O., Soltveit, H. K., Song, H., Sopicki, P., Sorbi, M., Spallino, L., Spannowsky, M., Spataro, B., Sphicas, P., Spiesberger, H., Spiller, P., Spira, M., Srivastava, T., Stachel, J., Stakia, A., Stanyard, J. L., Starchenko, E., Starikov, A. Yu., Stasto, A. M., Statera, M., Steerenberg, R., Steggemann, J., Stenvall, A., Stivanello, F., Stoeckinger, D., Stoel, L. S., Stoeger-Pollach, M., Strauss, B., Stuart, M., Stupakov, G., Su, S., Sublet, A., Sugita, K., Sulak, L., Sullivan, M. K., Sultansoy, S., Sumida, T., Suzuki, K., Sylva, G., Syphers, M. J., Sznajder, A., Taborelli, M., Tahir, N. A., Hod, E. Tal, Takeuchi, M., Tambasco, C., Tanaka, J., Tang, K., Tapan, I., Taroni, S., Tartarelli, G. F., Tassielli, G., Tavian, L., Taylor, T. M., Taylor, G. N., Teixeira, A. M., Tejeda-Munoz, G., Telnov, V. I., Tenchini, R., ten Kate, H. H. J., Terashi, K., Tesi, A., Testa, M., Tetrel, C., Teytelman, D., Thaler, J., Thamm, A., Thomas, S., Tiirakari, M. T., Tikhomirov, V., Tikhonov, D., Timko, H., Tisserand, V., Tkachenko, L. M., Tkaczuk, J., Tock, J. Ph., Todd, B., Todesco, E., Garcia, R. Tomas, Tommasini, D., Tonelli, G., Toral, F., Torims, T., Torre, R., Townsend, Z., Trant, R., Treille, D., Trentadue, L., Tricoli, A., Tricomi, A., Trischuk, W., Tropin, I. S., Tuchming, B., Tudora, A. A., Turbiarz, B., Cakir, I. Turk, Turri, M., Tydecks, T., Usovitsch, J., Uythoven, J., Vaglio, R., Valassi, A., Valchkova, F., Valdivia Garcia, M. A., Valente, P., Valente, R. U., Valente-Feliciano, A. -M., Valentino, G., Silva, L. Vale, Valet, J. M., Valizadeh, R., Valle, J. W. F., Vallecorsa, S., Vallone, G., van Leeuwen, M., van Rienen, U. H., van Riesen-Haupt, L., Varasteh, M., Vecchi, L., Vedrine, P., Velev, G., Veness, R., Ventura, A., Delsolaro, W. Venturini, Verducci, M., Verhaaren, C. B., Vernieri, C., Verweij, A. P., Verwilligen, O., Viazlo, O., Vicini, A., Viehhauser, G., Vignaroli, N., Vignolo, M., Vitrano, A., Vivarelli, I., Vlachos, S., Vogel, M., Vogt, D. M., Voelkl, V., Volkov, P., Volpini, G., von Ahnen, J., Vorotnikov, G., Voutsinas, G. G., Vysotsky, V., Wagner, U., Wallny, R., Wang, L. -T., Wang, R., Wang, K., Ward, B. F. L., Watson, T. P., Watson, N. K., Was, Z., Weiland, C., Weinzierl, S., Welsch, C. P., Wenninger, J., Widorski, M., Wiedemann, U. A., Wienands, H. -U., Wilkinson, G., Williams, P. H., Winter, A., Wohlfahrt, A., Wojton, T., Wollmann, D., Womersley, J., Woog, D., Wu, X., Wulzer, A., Yanehsari, M. K., Yang, G., Yang, H. J., Yao, W. -M., Yazgan, E., Yermolchik, V., Yilmaz, Ay., Yilmaz, Al., Yoo, H. -D., Yost, S. A., You, T., Young, C., Yu, T. -T., Yu, F., Zaborowska, A., Zadeh, S. G., Zahnd, M., Zanetti, M., Zanotto, L., Zawiejski, L., Zeiler, P., Zerlauth, M., Zernov, S. M., Porta, G. Zevi Dell, Zhang, Z., Zhang, Y., Zhang, C., Zhang, H., Zhao, Z., Zhong, Y. -M., Zhou, J., Zhou, D., Zhuang, P., Zick, G., Zimmermann, F., Zinn-Justin, J., Zivkovic, L., Zlobin, A. V., Zobov, M., Zupan, J., and Zurita, J.
Abstract: We review the physics opportunities of the Future Circular Collider, covering its e(+)e(-), pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics.
Published: 2019
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35. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function., Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
Published: 2018
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36. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function., Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
Published: 2018
Full Text: View/download PDF

37. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function., Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
Published: 2018
Full Text: View/download PDF

38. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Author: Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, and Kleineidam, Luca
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018

39. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Göran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Göran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018
Full Text: View/download PDF

40. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, G. (Gail), Lam, M. (Max), Harris, S.E. (Sarah), Trampush, J.W. (Joey W.), Luciano, M. (Michelle), Hill, W.D. (W. David), Hagenaars, S. (Saskia), Ritchie, S.J. (Stuart J.), Marioni, R.E. (Riccardo), Fawns-Ritchie, C., Liewald, D.C.M. (David C. M.), Okely, J.A. (Judith A.), Ahola-Olli, A.V. (Ari V.), Barnes, C.L.K. (Catriona L. K.), Bertram, L. (Lars), Bis, J.C. (Joshua), Burdick, K.E. (Katherine E.), Christoforou, A. (Andrea), Derosse, P. (Pamela), Djurovic, S. (Srdjan), Espeseth, T. (Thomas), Giakoumaki, S. (Stella), Giddaluru, S. (Sudheer), Gustavson, D.E. (Daniel E.), Hayward, C. (Caroline), Hofer, E. (Edith), Ikram, M.A. (Arfan), Karlsson, R. (Robert), Knowles, E. (Emma), Lahti, J. (Jari), Leber, I. (Isabelle), Li, S. (Shuo), Mather, R., Melle, I. (Ingrid), Morris, D. (Derek), Oldmeadow, C. (Christopher), Palviainen, T. (Teemu), Payton, A. (Antony), Pazoki, R. (Raha), Petrovic, K. (Katja), Reynolds, C.A. (C.), Sargurupremraj, M. (Muralidharan), Scholz, M. (Markus), Smith, J.A. (Jennifer A), Smith, A.V. (Albert), Terzikhan, N. (Natalie), Thalamuthu, A. (Anbupalam), Trompet, S. (Stella), Lee, S.J. (Sven) van der, Ware, E.B. (Erin B.), Windham, B.G. (Gwen), Wright, M.J. (Margaret J.), Yang, J. (Jingyun), Yu, J. (Jin), Ames, D.J. (David), Amin, N. (Najaf), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Armstrong, N.J. (Nicola J.), Assareh, A.A., Attia, J. (John), Attix, D. (Deborah), Avramopoulos, D. (Dimitrios), Bennett, D.A. (David), Böhmer, M.R. (Marcel), Boyle, P.A. (Patricia A.), Brodaty, H. (Henry), Campbell, H. (Harry), Cannon, T.D. (Tyrone D.), Cirulli, E.T. (Elizabeth T.), Congdon, E. (Eliza), Conley, E.D. (Emily Drabant), Corley, J. (Janie), Cox, S.R. (Simon R.), Dale, A.M. (Anders), Dehghan, A. (Abbas), Dick, D. (Danielle), Dickinson, D. (Dwight), Hagen, K. (Knut), Evangelou, E. (Evangelos), Faul, J.D. (Jessica D.), Ford, I. (Ian), Freimer, N.A. (Nelson A.), Gao, H. (He), Giegling, I. (Ina), Gillespie, N.A. (Nathan A.), Gordon, S.D. (Scott D.), Gottesman, R.F. (Rebecca), Griswold, M.D. (Michael), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hartmann, A.M. (Annette M), Hatzimanolis, A. (Alex), Heiss, G. (Gerardo), Holliday, E.G. (Elizabeth), Joshi, P.K. (Peter), Kähönen, M. (Mika), Kardia, S.L.R. (Sharon L. R.), Karlsson, I. (Ida), Kleineidam, L. (Luca), Knopman, D.S. (David), Kochan, N.A. (Nicole A.), Konte, B. (Bettina), Kwok, J.B.J. (John), Le Hellard, S. (Stephanie), Lee, T. (Teresa), Lehtimäki, T. (Terho), Li, S.-C. (Shu-Chen), Liu, T. (Tian), Koini, M. (Marisa), London, E. (Edythe), Longstreth Jr, W.T., Lopez, O.L. (Oscar), Loukola, A. (Anu), Luck, T. (Tobias), Lundervold, A.J. (Astri), Lundquist, A. (Anders), Lyytikäinen, L.-P. (Leo-Pekka), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant W.), Murray, A.D. (Alison D.), Need, A.C. (Anna C.), Noordam, R. (Raymond), Nyberg, L. (Lisa), Ollier, W.E.R. (William), Papenberg, G., Pattie, A. (Alison), Polasek, O. (Ozren), Poldrack, R.A. (Russell A.), Psaty, B.M. (Bruce M.), Reppermund, S., Riedel-Heller, S. (Steffi), Rose, R.J. (Richard), Rotter, J.I. (Jerome I.), Roussos, A. (Alexandra), Rovio, S.P. (Suvi P.), Saba, Y. (Yasaman), Sabb, F.W. (Fred W.), Sachdev, P.S. (Perminder), Satizabal, C.L. (Claudia), Schmid, M. (Matthias), Scott, R.J. (Rodney J.), Scult, M.A. (Matthew A.), Simino, J. (Jeannette), Slagboom, P.E. (Eline), Smyrnis, N. (Nikolaos), Soumaré, A. (Aicha), Stefanis, N.C. (Nikos C.), Stott, D.J. (David. J.), Straub, R.E. (Richard), Sundet, K. (Kjetil), Taylor, A.M. (Adele M.), Taylor, K.D. (Kent), Tzoulaki, I., Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Voineskos, A.N. (Aristotle N.), Kaprio, J. (Jaakko), Wagner, M. (Michael), Wagner, H. (Hermann), Weinhold, L. (Leonie), Wen, K.H. (K. Hoyan), Widen, E., Yang, Q. (Qiong Fang), Zhao, W. (Wei), Adams, H.H.H. (Hieab), Arking, D.E. (Dan), Bilder, R.M. (Robert M.), Bitsios, P. (Panos), Boerwinkle, E. (Eric), Chiba-Falek, O. (Ornit), Corvin, A. (Aiden), Jager, P.L. (Philip) de, Debette, S. (Stéphanie), Donohoe, D.J. (Dennis), Elliott, P. (Paul), Fitzpatrick, A.L. (Annette), Gill, M. (Michael), Glahn, D.C. (David), Hägg, S. (Sara), Hansell, N.K. (Narelle), Hariri, A.R. (Ahmad), Ikram, M.K. (Kamran), Jukema, J.W. (Jan Wouter), Vuoksimaa, E. (Eero), Keller, M.C. (Matthew C), Kremen, W.S. (William S.), Launer, L.J. (Lenore), Lindenberger, U. (Ulman), Palotie, A. (Aarno), Pedersen, N.L. (Nancy), Pendleton, N. (Neil), Porteous, D.J. (David J.), Räikkönen, K. (Katri), Raitakari, O.T. (Olli T.), Ramirez, A. (Alfredo), Reinvang, I. (Ivar), Rudan, I. (Igor), Rujescu, D. (Dan), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, P.W. (Peter W.), Schofield, C.J. (Christopher), Starr, J.M. (John), Steen, V.M. (Vidar), Trollor, J., Turner, S.T. (Steven T.), Duijn, C.M. (Cornelia) van, Villringer, A. (Arno), Weinberger, D.R. (Daniel), Weir, D.R. (David R.), Wilson, J.F. (James F.), Malhotra, A.K. (Anil K), McIntosh, A.M. (Andrew), Gale, C.R. (Catharine R.), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Bressler, J. (Jan), Lencz, T. (Todd), Deary, I.J. (Ian), Davies, G. (Gail), Lam, M. (Max), Harris, S.E. (Sarah), Trampush, J.W. (Joey W.), Luciano, M. (Michelle), Hill, W.D. (W. David), Hagenaars, S. (Saskia), Ritchie, S.J. (Stuart J.), Marioni, R.E. (Riccardo), Fawns-Ritchie, C., Liewald, D.C.M. (David C. M.), Okely, J.A. (Judith A.), Ahola-Olli, A.V. (Ari V.), Barnes, C.L.K. (Catriona L. K.), Bertram, L. (Lars), Bis, J.C. (Joshua), Burdick, K.E. (Katherine E.), Christoforou, A. (Andrea), Derosse, P. (Pamela), Djurovic, S. (Srdjan), Espeseth, T. (Thomas), Giakoumaki, S. (Stella), Giddaluru, S. (Sudheer), Gustavson, D.E. (Daniel E.), Hayward, C. (Caroline), Hofer, E. (Edith), Ikram, M.A. (Arfan), Karlsson, R. (Robert), Knowles, E. (Emma), Lahti, J. (Jari), Leber, I. (Isabelle), Li, S. (Shuo), Mather, R., Melle, I. (Ingrid), Morris, D. (Derek), Oldmeadow, C. (Christopher), Palviainen, T. (Teemu), Payton, A. (Antony), Pazoki, R. (Raha), Petrovic, K. (Katja), Reynolds, C.A. (C.), Sargurupremraj, M. (Muralidharan), Scholz, M. (Markus), Smith, J.A. (Jennifer A), Smith, A.V. (Albert), Terzikhan, N. (Natalie), Thalamuthu, A. (Anbupalam), Trompet, S. (Stella), Lee, S.J. (Sven) van der, Ware, E.B. (Erin B.), Windham, B.G. (Gwen), Wright, M.J. (Margaret J.), Yang, J. (Jingyun), Yu, J. (Jin), Ames, D.J. (David), Amin, N. (Najaf), Amouyel, P. (Philippe), Andreassen, O.A. (Ole), Armstrong, N.J. (Nicola J.), Assareh, A.A., Attia, J. (John), Attix, D. (Deborah), Avramopoulos, D. (Dimitrios), Bennett, D.A. (David), Böhmer, M.R. (Marcel), Boyle, P.A. (Patricia A.), Brodaty, H. (Henry), Campbell, H. (Harry), Cannon, T.D. (Tyrone D.), Cirulli, E.T. (Elizabeth T.), Congdon, E. (Eliza), Conley, E.D. (Emily Drabant), Corley, J. (Janie), Cox, S.R. (Simon R.), Dale, A.M. (Anders), Dehghan, A. (Abbas), Dick, D. (Danielle), Dickinson, D. (Dwight), Hagen, K. (Knut), Evangelou, E. (Evangelos), Faul, J.D. (Jessica D.), Ford, I. (Ian), Freimer, N.A. (Nelson A.), Gao, H. (He), Giegling, I. (Ina), Gillespie, N.A. (Nathan A.), Gordon, S.D. (Scott D.), Gottesman, R.F. (Rebecca), Griswold, M.D. (Michael), Gudnason, V. (Vilmundur), Harris, T.B. (Tamara), Hartmann, A.M. (Annette M), Hatzimanolis, A. (Alex), Heiss, G. (Gerardo), Holliday, E.G. (Elizabeth), Joshi, P.K. (Peter), Kähönen, M. (Mika), Kardia, S.L.R. (Sharon L. R.), Karlsson, I. (Ida), Kleineidam, L. (Luca), Knopman, D.S. (David), Kochan, N.A. (Nicole A.), Konte, B. (Bettina), Kwok, J.B.J. (John), Le Hellard, S. (Stephanie), Lee, T. (Teresa), Lehtimäki, T. (Terho), Li, S.-C. (Shu-Chen), Liu, T. (Tian), Koini, M. (Marisa), London, E. (Edythe), Longstreth Jr, W.T., Lopez, O.L. (Oscar), Loukola, A. (Anu), Luck, T. (Tobias), Lundervold, A.J. (Astri), Lundquist, A. (Anders), Lyytikäinen, L.-P. (Leo-Pekka), Martin, N.G. (Nicholas), Montgomery, G.W. (Grant W.), Murray, A.D. (Alison D.), Need, A.C. (Anna C.), Noordam, R. (Raymond), Nyberg, L. (Lisa), Ollier, W.E.R. (William), Papenberg, G., Pattie, A. (Alison), Polasek, O. (Ozren), Poldrack, R.A. (Russell A.), Psaty, B.M. (Bruce M.), Reppermund, S., Riedel-Heller, S. (Steffi), Rose, R.J. (Richard), Rotter, J.I. (Jerome I.), Roussos, A. (Alexandra), Rovio, S.P. (Suvi P.), Saba, Y. (Yasaman), Sabb, F.W. (Fred W.), Sachdev, P.S. (Perminder), Satizabal, C.L. (Claudia), Schmid, M. (Matthias), Scott, R.J. (Rodney J.), Scult, M.A. (Matthew A.), Simino, J. (Jeannette), Slagboom, P.E. (Eline), Smyrnis, N. (Nikolaos), Soumaré, A. (Aicha), Stefanis, N.C. (Nikos C.), Stott, D.J. (David. J.), Straub, R.E. (Richard), Sundet, K. (Kjetil), Taylor, A.M. (Adele M.), Taylor, K.D. (Kent), Tzoulaki, I., Tzourio, C. (Christophe), Uitterlinden, A.G. (André), Vitart, V. (Veronique), Voineskos, A.N. (Aristotle N.), Kaprio, J. (Jaakko), Wagner, M. (Michael), Wagner, H. (Hermann), Weinhold, L. (Leonie), Wen, K.H. (K. Hoyan), Widen, E., Yang, Q. (Qiong Fang), Zhao, W. (Wei), Adams, H.H.H. (Hieab), Arking, D.E. (Dan), Bilder, R.M. (Robert M.), Bitsios, P. (Panos), Boerwinkle, E. (Eric), Chiba-Falek, O. (Ornit), Corvin, A. (Aiden), Jager, P.L. (Philip) de, Debette, S. (Stéphanie), Donohoe, D.J. (Dennis), Elliott, P. (Paul), Fitzpatrick, A.L. (Annette), Gill, M. (Michael), Glahn, D.C. (David), Hägg, S. (Sara), Hansell, N.K. (Narelle), Hariri, A.R. (Ahmad), Ikram, M.K. (Kamran), Jukema, J.W. (Jan Wouter), Vuoksimaa, E. (Eero), Keller, M.C. (Matthew C), Kremen, W.S. (William S.), Launer, L.J. (Lenore), Lindenberger, U. (Ulman), Palotie, A. (Aarno), Pedersen, N.L. (Nancy), Pendleton, N. (Neil), Porteous, D.J. (David J.), Räikkönen, K. (Katri), Raitakari, O.T. (Olli T.), Ramirez, A. (Alfredo), Reinvang, I. (Ivar), Rudan, I. (Igor), Rujescu, D. (Dan), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Schofield, P.W. (Peter W.), Schofield, C.J. (Christopher), Starr, J.M. (John), Steen, V.M. (Vidar), Trollor, J., Turner, S.T. (Steven T.), Duijn, C.M. (Cornelia) van, Villringer, A. (Arno), Weinberger, D.R. (Daniel), Weir, D.R. (David R.), Wilson, J.F. (James F.), Malhotra, A.K. (Anil K), McIntosh, A.M. (Andrew), Gale, C.R. (Catharine R.), Seshadri, S. (Sudha), Mosley, T.H. (Thomas H.), Bressler, J. (Jan), Lencz, T. (Todd), and Deary, I.J. (Ian)
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the c
Published: 2018
Full Text: View/download PDF

41. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Knopman, David S, Kochan, Nicole A, Konte, Bettina, Kwok, John B, Le Hellard, Stephanie, Lee, Teresa, Lehtimäki, Terho, Li, Shu-Chen, Lill, Christina M, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T, Lopez, Oscar L, Loukola, Anu, Luck, Tobias, Lundervold, Astri J, Lundquist, Anders, Lyytikäinen, Leo-Pekka, Martin, Nicholas G, Montgomery, Grant W, Murray, Alison D, Need, Anna C, Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A, Psaty, Bruce M, Reppermund, Simone, Riedel-Heller, Steffi G, Rose, Richard J, Rotter, Jerome I, Roussos, Panos, Rovio, Suvi P, Saba, Yasaman, Sabb, Fred W, Sachdev, Perminder S, Satizabal, Claudia L, Schmid, Matthias, Scott, Rodney J, Scult, Matthew A, Simino, Jeannette, Slagboom, P Eline, Smyrnis, Nikolaos, Soumaré, Aïcha, Stefanis, Nikos C, Stott, David J, Straub, Richard E, Sundet, Kjetil, Taylor, Adele M, Taylor, Kent D, Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André, Vitart, Veronique, Voineskos, Aristotle N, Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab HH, Arking, Dan E, Bilder, Robert M, Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L, Debette, Stéphanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L, Gill, Michael, Glahn, David C, Hägg, Sara, Hansell, Narelle K, Hariri, Ahmad R, Ikram, M Kamran, Jukema, J Wouter, Vuoksimaa, Eero, Keller, Matthew C, Kremen, William S, Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L, Pendleton, Neil, Porteous, David J, Räikkönen, Katri, Raitakari, Olli T, Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Dan Rujescu, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W, Schofield, Peter R, Starr, John M, Steen, Vidar M, Trollor, Julian N, Turner, Steven T, Van Duijn, Cornelia M, Villringer, Arno, Weinberger, Daniel R, Weir, David R, Wilson, James F, Malhotra, Anil, McIntosh, Andrew M, Gale, Catharine R, Seshadri, Sudha, Mosley, Thomas H, Bressler, Jan, Lencz, Todd, Deary, Ian J, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Knopman, David S, Kochan, Nicole A, Konte, Bettina, Kwok, John B, Le Hellard, Stephanie, Lee, Teresa, Lehtimäki, Terho, Li, Shu-Chen, Lill, Christina M, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T, Lopez, Oscar L, Loukola, Anu, Luck, Tobias, Lundervold, Astri J, Lundquist, Anders, Lyytikäinen, Leo-Pekka, Martin, Nicholas G, Montgomery, Grant W, Murray, Alison D, Need, Anna C, Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A, Psaty, Bruce M, Reppermund, Simone, Riedel-Heller, Steffi G, Rose, Richard J, Rotter, Jerome I, Roussos, Panos, Rovio, Suvi P, Saba, Yasaman, Sabb, Fred W, Sachdev, Perminder S, Satizabal, Claudia L, Schmid, Matthias, Scott, Rodney J, Scult, Matthew A, Simino, Jeannette, Slagboom, P Eline, Smyrnis, Nikolaos, Soumaré, Aïcha, Stefanis, Nikos C, Stott, David J, Straub, Richard E, Sundet, Kjetil, Taylor, Adele M, Taylor, Kent D, Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André, Vitart, Veronique, Voineskos, Aristotle N, Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab HH, Arking, Dan E, Bilder, Robert M, Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L, Debette, Stéphanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L, Gill, Michael, Glahn, David C, Hägg, Sara, Hansell, Narelle K, Hariri, Ahmad R, Ikram, M Kamran, Jukema, J Wouter, Vuoksimaa, Eero, Keller, Matthew C, Kremen, William S, Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L, Pendleton, Neil, Porteous, David J, Räikkönen, Katri, Raitakari, Olli T, Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Dan Rujescu, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W, Schofield, Peter R, Starr, John M, Steen, Vidar M, Trollor, Julian N, Turner, Steven T, Van Duijn, Cornelia M, Villringer, Arno, Weinberger, Daniel R, Weir, David R, Wilson, James F, Malhotra, Anil, McIntosh, Andrew M, Gale, Catharine R, Seshadri, Sudha, Mosley, Thomas H, Bressler, Jan, Lencz, Todd, and Deary, Ian J
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018

42. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018

43. Model independent study for the anomalous quartic $WW\gamma\gamma$ couplings at Future Electron-Proton Colliders

Author: Ari, V., Gurkanli, E., Billur, A. A., Koksal, M., Ari, V., Gurkanli, E., Billur, A. A., and Koksal, M.
Abstract: The Large Hadron Electron Collider and the Future Circular Collider-hadron electron with high center-of-mass energy and luminosity allow to better understand the Standard Model and to examine new physics beyond the Standard Model in the electroweak sector. Multi-boson processes permit for a measurement of the gauge boson self-interactions of the Standard Model that can be used to determine the anomalous gauge boson couplings. For this purpose, we present a study of the process $ep \rightarrow \nu_{e} \gamma \gamma j$ at the Large Hadron Electron Collider with center-of-mass energies of 1.30, 1.98 TeV and at the Future Circular Collider-hadron electron with center-of-mass energies of 7.07, 10 TeV to interpret the anomalous quartic $WW\gamma\gamma$ gauge couplings using a model independent way in the framework of effective field theory. We obtain the sensitivity limits at $95\%$ Confidence Level on 13 different anomalous couplings arising from dimension-8 operators. The best limit in $f_{Mi}/\Lambda^{4}$ ($i=0,1,2,3,4,5,7$) parameters is obtained for $f_{M2}/\Lambda^{4}$ parameter while the best sensitivity derived on $f_{Ti}/\Lambda^{4}$ ($i=0,1,2,5,6,7$) parameters is obtained for $f_{T5}/\Lambda^{4}$. In addition, this study is the first report on the anomalous quartic couplings determined by effective Lagrangians at $ep$ colliders., Comment: 28 Pages, 15 Figures and 7 Tables
Published: 2018
Full Text: View/download PDF

44. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

Author: Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Davies, Gail, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, and Kleineidam, Luca
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018

45. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Knopman, David S, Kochan, Nicole A, Konte, Bettina, Kwok, John B, Le Hellard, Stephanie, Lee, Teresa, Lehtimäki, Terho, Li, Shu-Chen, Lill, Christina M, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T, Lopez, Oscar L, Loukola, Anu, Luck, Tobias, Lundervold, Astri J, Lundquist, Anders, Lyytikäinen, Leo-Pekka, Martin, Nicholas G, Montgomery, Grant W, Murray, Alison D, Need, Anna C, Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A, Psaty, Bruce M, Reppermund, Simone, Riedel-Heller, Steffi G, Rose, Richard J, Rotter, Jerome I, Roussos, Panos, Rovio, Suvi P, Saba, Yasaman, Sabb, Fred W, Sachdev, Perminder S, Satizabal, Claudia L, Schmid, Matthias, Scott, Rodney J, Scult, Matthew A, Simino, Jeannette, Slagboom, P Eline, Smyrnis, Nikolaos, Soumaré, Aïcha, Stefanis, Nikos C, Stott, David J, Straub, Richard E, Sundet, Kjetil, Taylor, Adele M, Taylor, Kent D, Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André, Vitart, Veronique, Voineskos, Aristotle N, Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab HH, Arking, Dan E, Bilder, Robert M, Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L, Debette, Stéphanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L, Gill, Michael, Glahn, David C, Hägg, Sara, Hansell, Narelle K, Hariri, Ahmad R, Ikram, M Kamran, Jukema, J Wouter, Vuoksimaa, Eero, Keller, Matthew C, Kremen, William S, Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L, Pendleton, Neil, Porteous, David J, Räikkönen, Katri, Raitakari, Olli T, Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Dan Rujescu, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W, Schofield, Peter R, Starr, John M, Steen, Vidar M, Trollor, Julian N, Turner, Steven T, Van Duijn, Cornelia M, Villringer, Arno, Weinberger, Daniel R, Weir, David R, Wilson, James F, Malhotra, Anil, McIntosh, Andrew M, Gale, Catharine R, Seshadri, Sudha, Mosley, Thomas H, Bressler, Jan, Lencz, Todd, Deary, Ian J, Davies, Gail, Lam, Max, Harris, Sarah E, Trampush, Joey W, Luciano, Michelle, Hill, W David, Hagenaars, Saskia P, Ritchie, Stuart J, Marioni, Riccardo E, Fawns-Ritchie, Chloe, Liewald, David CM, Okely, Judith A, Ahola-Olli, Ari V, Barnes, Catriona LK, Bertram, Lars, Bis, Joshua C, Burdick, Katherine E, Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E, Hayward, Caroline, Hofer, Edith, Ikram, M Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A, Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A, Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A, Smith, Albert V, Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J, Ware, Erin B, Windham, B Gwen, Wright, Margaret J, Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A, Armstrong, Nicola J, Assareh, Amelia A, Attia, John R, Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A, Böhmer, Anne C, Boyle, Patricia A, Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D, Cirulli, Elizabeth T, Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R, Dale, Anders M, Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G, Evangelou, Evangelos, Faul, Jessica D, Ford, Ian, Freimer, Nelson A, Gao, He, Giegling, Ina, Gillespie, Nathan A, Gordon, Scott D, Gottesman, Rebecca F, Griswold, Michael E, Gudnason, Vilmundur, Harris, Tamara B, Hartmann, Annette M, Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G, Joshi, Peter K, Kähönen, Mika, Kardia, Sharon LR, Karlsson, Ida, Kleineidam, Luca, Knopman, David S, Kochan, Nicole A, Konte, Bettina, Kwok, John B, Le Hellard, Stephanie, Lee, Teresa, Lehtimäki, Terho, Li, Shu-Chen, Lill, Christina M, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T, Lopez, Oscar L, Loukola, Anu, Luck, Tobias, Lundervold, Astri J, Lundquist, Anders, Lyytikäinen, Leo-Pekka, Martin, Nicholas G, Montgomery, Grant W, Murray, Alison D, Need, Anna C, Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A, Psaty, Bruce M, Reppermund, Simone, Riedel-Heller, Steffi G, Rose, Richard J, Rotter, Jerome I, Roussos, Panos, Rovio, Suvi P, Saba, Yasaman, Sabb, Fred W, Sachdev, Perminder S, Satizabal, Claudia L, Schmid, Matthias, Scott, Rodney J, Scult, Matthew A, Simino, Jeannette, Slagboom, P Eline, Smyrnis, Nikolaos, Soumaré, Aïcha, Stefanis, Nikos C, Stott, David J, Straub, Richard E, Sundet, Kjetil, Taylor, Adele M, Taylor, Kent D, Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, André, Vitart, Veronique, Voineskos, Aristotle N, Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab HH, Arking, Dan E, Bilder, Robert M, Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L, Debette, Stéphanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L, Gill, Michael, Glahn, David C, Hägg, Sara, Hansell, Narelle K, Hariri, Ahmad R, Ikram, M Kamran, Jukema, J Wouter, Vuoksimaa, Eero, Keller, Matthew C, Kremen, William S, Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L, Pendleton, Neil, Porteous, David J, Räikkönen, Katri, Raitakari, Olli T, Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Dan Rujescu, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W, Schofield, Peter R, Starr, John M, Steen, Vidar M, Trollor, Julian N, Turner, Steven T, Van Duijn, Cornelia M, Villringer, Arno, Weinberger, Daniel R, Weir, David R, Wilson, James F, Malhotra, Anil, McIntosh, Andrew M, Gale, Catharine R, Seshadri, Sudha, Mosley, Thomas H, Bressler, Jan, Lencz, Todd, and Deary, Ian J
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018

46. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Published: 2018

47. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function., Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
Published: 2018
Full Text: View/download PDF

48. Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Author: Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, Deary, Ian J., Davies, Gail, Lam, Max, Harris, Sarah E., Trampush, Joey W., Luciano, Michelle, Hill, W. David, Hagenaars, Saskia P., Ritchie, Stuart J., Marioni, Riccardo E., Fawns-Ritchie, Chloe, Liewald, David C. M., Okely, Judith A., Ahola-Olli, Ari V., Barnes, Catriona L. K., Bertram, Lars, Bis, Joshua C., Burdick, Katherine E., Christoforou, Andrea, DeRosse, Pamela, Djurovic, Srdjan, Espeseth, Thomas, Giakoumaki, Stella, Giddaluru, Sudheer, Gustavson, Daniel E., Hayward, Caroline, Hofer, Edith, Ikram, M. Arfan, Karlsson, Robert, Knowles, Emma, Lahti, Jari, Leber, Markus, Li, Shuo, Mather, Karen A., Melle, Ingrid, Morris, Derek, Oldmeadow, Christopher, Palviainen, Teemu, Payton, Antony, Pazoki, Raha, Petrovic, Katja, Reynolds, Chandra A., Sargurupremraj, Muralidharan, Scholz, Markus, Smith, Jennifer A., Smith, Albert V., Terzikhan, Natalie, Thalamuthu, Anbupalam, Trompet, Stella, van der Lee, Sven J., Ware, Erin B., Windham, B. Gwen, Wright, Margaret J., Yang, Jingyun, Yu, Jin, Ames, David, Amin, Najaf, Amouyel, Philippe, Andreassen, Ole A., Armstrong, Nicola J., Assareh, Amelia A., Attia, John R., Attix, Deborah, Avramopoulos, Dimitrios, Bennett, David A., Boehmer, Anne C., Boyle, Patricia A., Brodaty, Henry, Campbell, Harry, Cannon, Tyrone D., Cirulli, Elizabeth T., Congdon, Eliza, Conley, Emily Drabant, Corley, Janie, Cox, Simon R., Dale, Anders M., Dehghan, Abbas, Dick, Danielle, Dickinson, Dwight, Eriksson, Johan G., Evangelou, Evangelos, Faul, Jessica D., Ford, Ian, Freimer, Nelson A., Gao, He, Giegling, Ina, Gillespie, Nathan A., Gordon, Scott D., Gottesman, Rebecca F., Griswold, Michael E., Gudnason, Vilmundur, Harris, Tamara B., Hartmann, Annette M., Hatzimanolis, Alex, Heiss, Gerardo, Holliday, Elizabeth G., Joshi, Peter K., Kahonen, Mika, Kardia, Sharon L. R., Karlsson, Ida, Kleineidam, Luca, Knopman, David S., Kochan, Nicole A., Konte, Bettina, Kwok, John B., Le Hellard, Stephanie, Lee, Teresa, Lehtimaki, Terho, Li, Shu-Chen, Liu, Tian, Koini, Marisa, London, Edythe, Longstreth, Will T., Jr., Lopez, Oscar L., Loukola, Anu, Luck, Tobias, Lundervold, Astri J., Lundquist, Anders, Lyytikainen, Leo-Pekka, Martin, Nicholas G., Montgomery, Grant W., Murray, Alison D., Need, Anna C., Noordam, Raymond, Nyberg, Lars, Ollier, William, Papenberg, Goran, Pattie, Alison, Polasek, Ozren, Poldrack, Russell A., Psaty, Bruce M., Reppermund, Simone, Riedel-Heller, Steffi G., Rose, Richard J., Rotter, Jerome I., Roussos, Panos, Rovio, Suvi P., Saba, Yasaman, Sabb, Fred W., Sachdev, Perminder S., Satizabal, Claudia L., Schmid, Matthias, Scott, Rodney J., Scult, Matthew A., Simino, Jeannette, Slagboom, P. Eline, Smyrnis, Nikolaos, Soumare, Aicha, Stefanis, Nikos C., Stott, David J., Straub, Richard E., Sundet, Kjetil, Taylor, Adele M., Taylor, Kent D., Tzoulaki, Ioanna, Tzourio, Christophe, Uitterlinden, Andre, Vitart, Veronique, Voineskos, Aristotle N., Kaprio, Jaakko, Wagner, Michael, Wagner, Holger, Weinhold, Leonie, Wen, K. Hoyan, Widen, Elisabeth, Yang, Qiong, Zhao, Wei, Adams, Hieab H. H., Arking, Dan E., Bilder, Robert M., Bitsios, Panos, Boerwinkle, Eric, Chiba-Falek, Ornit, Corvin, Aiden, De Jager, Philip L., Debette, Stephanie, Donohoe, Gary, Elliott, Paul, Fitzpatrick, Annette L., Gill, Michael, Glahn, David C., Hagg, Sara, Hansell, Narelle K., Hariri, Ahmad R., Ikram, M. Kamran, Jukema, J. Wouter, Vuoksimaa, Eero, Keller, Matthew C., Kremen, William S., Launer, Lenore, Lindenberger, Ulman, Palotie, Aarno, Pedersen, Nancy L., Pendleton, Neil, Porteous, David J., Raikkonen, Katri, Raitakari, Olli T., Ramirez, Alfredo, Reinvang, Ivar, Rudan, Igor, Rujescu, Dan, Schmidt, Reinhold, Schmidt, Helena, Schofield, Peter W., Schofield, Peter R., Starr, John M., Steen, Vidar M., Trollor, Julian N., Turner, Steven T., Van Duijn, Cornelia M., Villringer, Arno, Weinberger, Daniel R., Weir, David R., Wilson, James F., Malhotra, Anil, McIntosh, Andrew M., Gale, Catharine R., Seshadri, Sudha, Mosley, Thomas H., Jr., Bressler, Jan, Lencz, Todd, and Deary, Ian J.
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function., Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
Published: 2018
Full Text: View/download PDF

49. Effects of the FCNC couplings in production of new heavy quarks within Z' models at the LHC

Author: Cetinkaya, V., Ari, V., Cakir, O., Cetinkaya, V., Ari, V., and Cakir, O.
Abstract: We study the flavor changing neutral current couplings of new heavy quarks through the Z' models at the LHC. We calculate the cross sections for the signal and the corresponding standard model background processes. Considering the present limits on the mass of new heavy quarks and the Z' boson, we performed an analysis to investigate the parameter space (mixing and mass) through different Z' models. For an FCNC mixing parameter x=0.1 and the Z' mass M_{Z'}=2000 GeV, and new heavy quark mass m_{t'}=700 GeV at the LHC with \sqrt{s}=13 TeV, we find the cross section for single production of new heavy quarks associated with top quarks as 5.8 fb, 3.3 fb, 1.5 fb and 1.2 fb within the Z'_{\eta} , Z'_{\psi} , Z'_{LP} and Z'_{\chi} models, respectively. It is shown that the sensitivity would benefit from the flavor tagging., Comment: 17 pages, 18 figures, update. arXiv admin note: text overlap with arXiv:1003.3156
Published: 2015

50. Pair Production of New Heavy Leptons with $U(1)'$ Charge at Linear Colliders

Author: Ari, V., Çakir, O., Kuday, S., Ari, V., Çakir, O., and Kuday, S.
Abstract: We study the pair production of new heavy leptons within a new $U(1)'$ symmetry extension of the Standard Model. Because of the new symmetry, the production and decay modes of the new heavy leptons would be different from those of three families of the standard model. The pair production cross sections depending on the mixing parameter and the mass of heavy leptons have been calculated for the center of mass energies of $0.5$ TeV, $1$ TeV and $3$ TeV. The accessible ranges of the parameters have been obtained for different luminosity projections at linear colliders. We find the sensitivity to the range of mixing parameter $-1
Published: 2013
Full Text: View/download PDF

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