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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Authors :
Davies, G. (Gail) Lam, M. (Max) Harris, S.E. (Sarah) Trampush, J.W. (Joey W.) Luciano, M. (Michelle) Hill, W.D. (W. David) Hagenaars, S. (Saskia) Ritchie, S.J. (Stuart J.) Marioni, R.E. (Riccardo) Fawns-Ritchie, C. Liewald, D.C.M. (David C. M.) Okely, J.A. (Judith A.) Ahola-Olli, A.V. (Ari V.) Barnes, C.L.K. (Catriona L. K.) Bertram, L. (Lars) Bis, J.C. (Joshua) Burdick, K.E. (Katherine E.) Christoforou, A. (Andrea) Derosse, P. (Pamela) Djurovic, S. (Srdjan) Espeseth, T. (Thomas) Giakoumaki, S. (Stella) Giddaluru, S. (Sudheer) Gustavson, D.E. (Daniel E.) Hayward, C. (Caroline) Hofer, E. (Edith) Ikram, M.A. (Arfan) Karlsson, R. (Robert) Knowles, E. (Emma) Lahti, J. (Jari) Leber, I. (Isabelle) Li, S. (Shuo) Mather, R. Melle, I. (Ingrid) Morris, D. (Derek) Oldmeadow, C. (Christopher) Palviainen, T. (Teemu) Payton, A. (Antony) Pazoki, R. (Raha) Petrovic, K. (Katja) Reynolds, C.A. (C.) Sargurupremraj, M. (Muralidharan) Scholz, M. (Markus) Smith, J.A. (Jennifer A) Smith, A.V. (Albert) Terzikhan, N. (Natalie) Thalamuthu, A. (Anbupalam) Trompet, S. (Stella) Lee, S.J. (Sven) van der Ware, E.B. (Erin B.) Windham, B.G. (Gwen) Wright, M.J. (Margaret J.) Yang, J. (Jingyun) Yu, J. (Jin) Ames, D.J. (David) Amin, N. (Najaf) Amouyel, P. (Philippe) Andreassen, O.A. (Ole) Armstrong, N.J. (Nicola J.) Assareh, A.A. Attia, J. (John) Attix, D. (Deborah) Avramopoulos, D. (Dimitrios) Bennett, D.A. (David) Böhmer, M.R. (Marcel) Boyle, P.A. (Patricia A.) Brodaty, H. (Henry) Campbell, H. (Harry) Cannon, T.D. (Tyrone D.) Cirulli, E.T. (Elizabeth T.) Congdon, E. (Eliza) Conley, E.D. (Emily Drabant) Corley, J. (Janie) Cox, S.R. (Simon R.) Dale, A.M. (Anders) Dehghan, A. (Abbas) Dick, D. (Danielle) Dickinson, D. (Dwight) Hagen, K. (Knut) Evangelou, E. (Evangelos) Faul, J.D. (Jessica D.) Ford, I. (Ian) Freimer, N.A. (Nelson A.) Gao, H. (He) Giegling, I. (Ina) Gillespie, N.A. (Nathan A.) Gordon, S.D. (Scott D.) Gottesman, R.F. (Rebecca) Griswold, M.D. (Michael) Gudnason, V. (Vilmundur) Harris, T.B. (Tamara) Hartmann, A.M. (Annette M) Hatzimanolis, A. (Alex) Heiss, G. (Gerardo) Holliday, E.G. (Elizabeth) Joshi, P.K. (Peter) Kähönen, M. (Mika) Kardia, S.L.R. (Sharon L. R.) Karlsson, I. (Ida) Kleineidam, L. (Luca) Knopman, D.S. (David) Kochan, N.A. (Nicole A.) Konte, B. (Bettina) Kwok, J.B.J. (John) Le Hellard, S. (Stephanie) Lee, T. (Teresa) Lehtimäki, T. (Terho) Li, S.-C. (Shu-Chen) Liu, T. (Tian) Koini, M. (Marisa) London, E. (Edythe) Longstreth Jr, W.T. Lopez, O.L. (Oscar) Loukola, A. (Anu) Luck, T. (Tobias) Lundervold, A.J. (Astri) Lundquist, A. (Anders) Lyytikäinen, L.-P. (Leo-Pekka) Martin, N.G. (Nicholas) Montgomery, G.W. (Grant W.) Murray, A.D. (Alison D.) Need, A.C. (Anna C.) Noordam, R. (Raymond) Nyberg, L. (Lisa) Ollier, W.E.R. (William) Papenberg, G. Pattie, A. (Alison) Polasek, O. (Ozren) Poldrack, R.A. (Russell A.) Psaty, B.M. (Bruce M.) Reppermund, S. Riedel-Heller, S. (Steffi) Rose, R.J. (Richard) Rotter, J.I. (Jerome I.) Roussos, A. (Alexandra) Rovio, S.P. (Suvi P.) Saba, Y. (Yasaman) Sabb, F.W. (Fred W.) Sachdev, P.S. (Perminder) Satizabal, C.L. (Claudia) Schmid, M. (Matthias) Scott, R.J. (Rodney J.) Scult, M.A. (Matthew A.) Simino, J. (Jeannette) Slagboom, P.E. (Eline) Smyrnis, N. (Nikolaos) Soumaré, A. (Aicha) Stefanis, N.C. (Nikos C.) Stott, D.J. (David. J.) Straub, R.E. (Richard) Sundet, K. (Kjetil) Taylor, A.M. (Adele M.) Taylor, K.D. (Kent) Tzoulaki, I. Tzourio, C. (Christophe) Uitterlinden, A.G. (André) Vitart, V. (Veronique) Voineskos, A.N. (Aristotle N.) Kaprio, J. (Jaakko) Wagner, M. (Michael) Wagner, H. (Hermann) Weinhold, L. (Leonie) Wen, K.H. (K. Hoyan) Widen, E. Yang, Q. (Qiong Fang) Zhao, W. (Wei) Adams, H.H.H. (Hieab) Arking, D.E. (Dan) Bilder, R.M. (Robert M.) Bitsios, P. (Panos) Boerwinkle, E. (Eric) Chiba-Falek, O. (Ornit) Corvin, A. (Aiden) Jager, P.L. (Philip) de Debette, S. (Stéphanie) Donohoe, D.J. (Dennis) Elliott, P. (Paul) Fitzpatrick, A.L. (Annette) Gill, M. (Michael) Glahn, D.C. (David) Hägg, S. (Sara) Hansell, N.K. (Narelle) Hariri, A.R. (Ahmad) Ikram, M.K. (Kamran) Jukema, J.W. (Jan Wouter) Vuoksimaa, E. (Eero) Keller, M.C. (Matthew C) Kremen, W.S. (William S.) Launer, L.J. (Lenore) Lindenberger, U. (Ulman) Palotie, A. (Aarno) Pedersen, N.L. (Nancy) Pendleton, N. (Neil) Porteous, D.J. (David J.) Räikkönen, K. (Katri) Raitakari, O.T. (Olli T.) Ramirez, A. (Alfredo) Reinvang, I. (Ivar) Rudan, I. (Igor) Rujescu, D. (Dan) Schmidt, R. (Reinhold) Schmidt, H. (Helena) Schofield, P.W. (Peter W.) Schofield, C.J. (Christopher) Starr, J.M. (John) Steen, V.M. (Vidar) Trollor, J. Turner, S.T. (Steven T.) Duijn, C.M. (Cornelia) van Villringer, A. (Arno) Weinberger, D.R. (Daniel) Weir, D.R. (David R.) Wilson, J.F. (James F.) Malhotra, A.K. (Anil K) McIntosh, A.M. (Andrew) Gale, C.R. (Catharine R.) Seshadri, S. (Sudha) Mosley, T.H. (Thomas H.) Bressler, J. (Jan) Lencz, T. (Todd) Deary, I.J. (Ian) Davies, G. (Gail) Lam, M. (Max) Harris, S.E. (Sarah) Trampush, J.W. (Joey W.) Luciano, M. (Michelle) Hill, W.D. (W. David) Hagenaars, S. (Saskia) Ritchie, S.J. (Stuart J.) Marioni, R.E. (Riccardo) Fawns-Ritchie, C. Liewald, D.C.M. (David C. M.) Okely, J.A. (Judith A.) Ahola-Olli, A.V. (Ari V.) Barnes, C.L.K. (Catriona L. K.) Bertram, L. (Lars) Bis, J.C. (Joshua) Burdick, K.E. (Katherine E.) Christoforou, A. (Andrea) Derosse, P. (Pamela) Djurovic, S. (Srdjan) Espeseth, T. (Thomas) Giakoumaki, S. (Stella) Giddaluru, S. (Sudheer) Gustavson, D.E. (Daniel E.) Hayward, C. (Caroline) Hofer, E. (Edith) Ikram, M.A. (Arfan) Karlsson, R. (Robert) Knowles, E. (Emma) Lahti, J. (Jari) Leber, I. (Isabelle) Li, S. (Shuo) Mather, R. Melle, I. (Ingrid) Morris, D. (Derek) Oldmeadow, C. (Christopher) Palviainen, T. (Teemu) Payton, A. (Antony) Pazoki, R. (Raha) Petrovic, K. (Katja) Reynolds, C.A. (C.) Sargurupremraj, M. (Muralidharan) Scholz, M. (Markus) Smith, J.A. (Jennifer A) Smith, A.V. (Albert) Terzikhan, N. (Natalie) Thalamuthu, A. (Anbupalam) Trompet, S. (Stella) Lee, S.J. (Sven) van der Ware, E.B. (Erin B.) Windham, B.G. (Gwen) Wright, M.J. (Margaret J.) Yang, J. (Jingyun) Yu, J. (Jin) Ames, D.J. (David) Amin, N. (Najaf) Amouyel, P. (Philippe) Andreassen, O.A. (Ole) Armstrong, N.J. (Nicola J.) Assareh, A.A. Attia, J. (John) Attix, D. (Deborah) Avramopoulos, D. (Dimitrios) Bennett, D.A. (David) Böhmer, M.R. (Marcel) Boyle, P.A. (Patricia A.) Brodaty, H. (Henry) Campbell, H. (Harry) Cannon, T.D. (Tyrone D.) Cirulli, E.T. (Elizabeth T.) Congdon, E. (Eliza) Conley, E.D. (Emily Drabant) Corley, J. (Janie) Cox, S.R. (Simon R.) Dale, A.M. (Anders) Dehghan, A. (Abbas) Dick, D. (Danielle) Dickinson, D. (Dwight) Hagen, K. (Knut) Evangelou, E. (Evangelos) Faul, J.D. (Jessica D.) Ford, I. (Ian) Freimer, N.A. (Nelson A.) Gao, H. (He) Giegling, I. (Ina) Gillespie, N.A. (Nathan A.) Gordon, S.D. (Scott D.) Gottesman, R.F. (Rebecca) Griswold, M.D. (Michael) Gudnason, V. (Vilmundur) Harris, T.B. (Tamara) Hartmann, A.M. (Annette M) Hatzimanolis, A. (Alex) Heiss, G. (Gerardo) Holliday, E.G. (Elizabeth) Joshi, P.K. (Peter) Kähönen, M. (Mika) Kardia, S.L.R. (Sharon L. R.) Karlsson, I. (Ida) Kleineidam, L. (Luca) Knopman, D.S. (David) Kochan, N.A. (Nicole A.) Konte, B. (Bettina) Kwok, J.B.J. (John) Le Hellard, S. (Stephanie) Lee, T. (Teresa) Lehtimäki, T. (Terho) Li, S.-C. (Shu-Chen) Liu, T. (Tian) Koini, M. (Marisa) London, E. (Edythe) Longstreth Jr, W.T. Lopez, O.L. (Oscar) Loukola, A. (Anu) Luck, T. (Tobias) Lundervold, A.J. (Astri) Lundquist, A. (Anders) Lyytikäinen, L.-P. (Leo-Pekka) Martin, N.G. (Nicholas) Montgomery, G.W. (Grant W.) Murray, A.D. (Alison D.) Need, A.C. (Anna C.) Noordam, R. (Raymond) Nyberg, L. (Lisa) Ollier, W.E.R. (William) Papenberg, G. Pattie, A. (Alison) Polasek, O. (Ozren) Poldrack, R.A. (Russell A.) Psaty, B.M. (Bruce M.) Reppermund, S. Riedel-Heller, S. (Steffi) Rose, R.J. (Richard) Rotter, J.I. (Jerome I.) Roussos, A. (Alexandra) Rovio, S.P. (Suvi P.) Saba, Y. (Yasaman) Sabb, F.W. (Fred W.) Sachdev, P.S. (Perminder) Satizabal, C.L. (Claudia) Schmid, M. (Matthias) Scott, R.J. (Rodney J.) Scult, M.A. (Matthew A.) Simino, J. (Jeannette) Slagboom, P.E. (Eline) Smyrnis, N. (Nikolaos) Soumaré, A. (Aicha) Stefanis, N.C. (Nikos C.) Stott, D.J. (David. J.) Straub, R.E. (Richard) Sundet, K. (Kjetil) Taylor, A.M. (Adele M.) Taylor, K.D. (Kent) Tzoulaki, I. Tzourio, C. (Christophe) Uitterlinden, A.G. (André) Vitart, V. (Veronique) Voineskos, A.N. (Aristotle N.) Kaprio, J. (Jaakko) Wagner, M. (Michael) Wagner, H. (Hermann) Weinhold, L. (Leonie) Wen, K.H. (K. Hoyan) Widen, E. Yang, Q. (Qiong Fang) Zhao, W. (Wei) Adams, H.H.H. (Hieab) Arking, D.E. (Dan) Bilder, R.M. (Robert M.) Bitsios, P. (Panos) Boerwinkle, E. (Eric) Chiba-Falek, O. (Ornit) Corvin, A. (Aiden) Jager, P.L. (Philip) de Debette, S. (Stéphanie) Donohoe, D.J. (Dennis) Elliott, P. (Paul) Fitzpatrick, A.L. (Annette) Gill, M. (Michael) Glahn, D.C. (David) Hägg, S. (Sara) Hansell, N.K. (Narelle) Hariri, A.R. (Ahmad) Ikram, M.K. (Kamran) Jukema, J.W. (Jan Wouter) Vuoksimaa, E. (Eero) Keller, M.C. (Matthew C) Kremen, W.S. (William S.) Launer, L.J. (Lenore) Lindenberger, U. (Ulman) Palotie, A. (Aarno) Pedersen, N.L. (Nancy) Pendleton, N. (Neil) Porteous, D.J. (David J.) Räikkönen, K. (Katri) Raitakari, O.T. (Olli T.) Ramirez, A. (Alfredo) Reinvang, I. (Ivar) Rudan, I. (Igor) Rujescu, D. (Dan) Schmidt, R. (Reinhold) Schmidt, H. (Helena) Schofield, P.W. (Peter W.) Schofield, C.J. (Christopher) Starr, J.M. (John) Steen, V.M. (Vidar) Trollor, J. Turner, S.T. (Steven T.) Duijn, C.M. (Cornelia) van Villringer, A. (Arno) Weinberger, D.R. (Daniel) Weir, D.R. (David R.) Wilson, J.F. (James F.) Malhotra, A.K. (Anil K) McIntosh, A.M. (Andrew) Gale, C.R. (Catharine R.) Seshadri, S. (Sudha) Mosley, T.H. (Thomas H.) Bressler, J. (Jan) Lencz, T. (Todd) Deary, I.J. (Ian)
Publication Year :
2018
Abstract
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 × 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the c
Details
Database :
OAIster
Notes :
application/pdf, Nature Communications vol. 9 no. 1, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1047726632
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41467-018-04362-x