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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Authors :
Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Boehmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kahonen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimaki, Terho Li, Shu-Chen Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T., Jr. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikainen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Goran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumare, Aicha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, Andre Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widen, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H. H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stephanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hagg, Sara Hansell, Narelle K. Hariri, Ahmad R. Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Raikkonen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Rujescu, Dan Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar M. Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H., Jr. Bressler, Jan Lencz, Todd Deary, Ian J. Davies, Gail Lam, Max Harris, Sarah E. Trampush, Joey W. Luciano, Michelle Hill, W. David Hagenaars, Saskia P. Ritchie, Stuart J. Marioni, Riccardo E. Fawns-Ritchie, Chloe Liewald, David C. M. Okely, Judith A. Ahola-Olli, Ari V. Barnes, Catriona L. K. Bertram, Lars Bis, Joshua C. Burdick, Katherine E. Christoforou, Andrea DeRosse, Pamela Djurovic, Srdjan Espeseth, Thomas Giakoumaki, Stella Giddaluru, Sudheer Gustavson, Daniel E. Hayward, Caroline Hofer, Edith Ikram, M. Arfan Karlsson, Robert Knowles, Emma Lahti, Jari Leber, Markus Li, Shuo Mather, Karen A. Melle, Ingrid Morris, Derek Oldmeadow, Christopher Palviainen, Teemu Payton, Antony Pazoki, Raha Petrovic, Katja Reynolds, Chandra A. Sargurupremraj, Muralidharan Scholz, Markus Smith, Jennifer A. Smith, Albert V. Terzikhan, Natalie Thalamuthu, Anbupalam Trompet, Stella van der Lee, Sven J. Ware, Erin B. Windham, B. Gwen Wright, Margaret J. Yang, Jingyun Yu, Jin Ames, David Amin, Najaf Amouyel, Philippe Andreassen, Ole A. Armstrong, Nicola J. Assareh, Amelia A. Attia, John R. Attix, Deborah Avramopoulos, Dimitrios Bennett, David A. Boehmer, Anne C. Boyle, Patricia A. Brodaty, Henry Campbell, Harry Cannon, Tyrone D. Cirulli, Elizabeth T. Congdon, Eliza Conley, Emily Drabant Corley, Janie Cox, Simon R. Dale, Anders M. Dehghan, Abbas Dick, Danielle Dickinson, Dwight Eriksson, Johan G. Evangelou, Evangelos Faul, Jessica D. Ford, Ian Freimer, Nelson A. Gao, He Giegling, Ina Gillespie, Nathan A. Gordon, Scott D. Gottesman, Rebecca F. Griswold, Michael E. Gudnason, Vilmundur Harris, Tamara B. Hartmann, Annette M. Hatzimanolis, Alex Heiss, Gerardo Holliday, Elizabeth G. Joshi, Peter K. Kahonen, Mika Kardia, Sharon L. R. Karlsson, Ida Kleineidam, Luca Knopman, David S. Kochan, Nicole A. Konte, Bettina Kwok, John B. Le Hellard, Stephanie Lee, Teresa Lehtimaki, Terho Li, Shu-Chen Liu, Tian Koini, Marisa London, Edythe Longstreth, Will T., Jr. Lopez, Oscar L. Loukola, Anu Luck, Tobias Lundervold, Astri J. Lundquist, Anders Lyytikainen, Leo-Pekka Martin, Nicholas G. Montgomery, Grant W. Murray, Alison D. Need, Anna C. Noordam, Raymond Nyberg, Lars Ollier, William Papenberg, Goran Pattie, Alison Polasek, Ozren Poldrack, Russell A. Psaty, Bruce M. Reppermund, Simone Riedel-Heller, Steffi G. Rose, Richard J. Rotter, Jerome I. Roussos, Panos Rovio, Suvi P. Saba, Yasaman Sabb, Fred W. Sachdev, Perminder S. Satizabal, Claudia L. Schmid, Matthias Scott, Rodney J. Scult, Matthew A. Simino, Jeannette Slagboom, P. Eline Smyrnis, Nikolaos Soumare, Aicha Stefanis, Nikos C. Stott, David J. Straub, Richard E. Sundet, Kjetil Taylor, Adele M. Taylor, Kent D. Tzoulaki, Ioanna Tzourio, Christophe Uitterlinden, Andre Vitart, Veronique Voineskos, Aristotle N. Kaprio, Jaakko Wagner, Michael Wagner, Holger Weinhold, Leonie Wen, K. Hoyan Widen, Elisabeth Yang, Qiong Zhao, Wei Adams, Hieab H. H. Arking, Dan E. Bilder, Robert M. Bitsios, Panos Boerwinkle, Eric Chiba-Falek, Ornit Corvin, Aiden De Jager, Philip L. Debette, Stephanie Donohoe, Gary Elliott, Paul Fitzpatrick, Annette L. Gill, Michael Glahn, David C. Hagg, Sara Hansell, Narelle K. Hariri, Ahmad R. Ikram, M. Kamran Jukema, J. Wouter Vuoksimaa, Eero Keller, Matthew C. Kremen, William S. Launer, Lenore Lindenberger, Ulman Palotie, Aarno Pedersen, Nancy L. Pendleton, Neil Porteous, David J. Raikkonen, Katri Raitakari, Olli T. Ramirez, Alfredo Reinvang, Ivar Rudan, Igor Rujescu, Dan Schmidt, Reinhold Schmidt, Helena Schofield, Peter W. Schofield, Peter R. Starr, John M. Steen, Vidar M. Trollor, Julian N. Turner, Steven T. Van Duijn, Cornelia M. Villringer, Arno Weinberger, Daniel R. Weir, David R. Wilson, James F. Malhotra, Anil McIntosh, Andrew M. Gale, Catharine R. Seshadri, Sudha Mosley, Thomas H., Jr. Bressler, Jan Lencz, Todd Deary, Ian J.
Publication Year :
2018
Abstract
General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P < 5 x 10-8) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.<br />Errata: Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., … Deary, I. J. (2019). Author correction to Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. [Nature Communications (2018), 9, Article number 2098]. Nature Communications, 10, Article number: 2068. DOI: 10.1038/s41467-019-10160-w
Details
Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1234380746
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41467-018-04362-x