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Phase change material (PCM) are characterized by their high latent heat and low density. Combining PCM with building walls, aircraft fuselages, and other structures can significantly enhance the thermal sink capability of these structures. In order to address the issue of low heat storage efficiency resulting from the low thermal conductivity of PCM, a novel integrated thermal protection structure (ITPS) architecture with a supportive structure based on a porous lattice has been designed. Experimental and numerical methods were employed to investigate the thermal response characteristics of the ITPS with and without PCM, the melting behavior of PCM within the porous lattice, and the effects of lattice configuration and pore size on the PCM melting rate. The current ITPS study includes evaluation of two types of lattice configurations and three different pore sizes. The results indicate that the inclusion of PCM reduces the internal panel temperature of the ITPS by approximately 15%. The melting of PCM occurs primarily at the central region of the porous lattice and gradually spreads towards the periphery until complete melting is achieved. Specifically, the Gibson–Ashby lattice configuration enhances the PCM melting rate by 43.5%, while the tetradecahedron lattice configuration yields a 53.1% improvement. Furthermore, for PCM with different pore sizes, smaller pores exhibit faster melting rates during the early and intermediate stages, whereas larger pores exhibit faster melting rates in the later stages as the proportion of liquid PCM increases. The conclusions of this study provide valuable insights for the application of PCM in the field of thermal management.

The structural anisotropy of open-cell foam leads to the anisotropy of effective thermal conductivity (ETC). To quantitatively analyze the effect of structural anisotropy on the anisotropy of ETC, a new predicting model for the ETC of anisotropic open-cell foam was proposed based on an anisotropy tetrakaidecahedron cell (ATC). Feret diameters in three orthogonal directions obtained by morphological analysis of real foam structures were used to characterize the anisotropy of ATC. To validate our proposed anisotropic model, the ETCs of real foam structures in three orthogonal directions predicted by it were compared with the numerical results, for which the structures of numerical models are reconstructed by X-ray computed tomography (X-CT). Using the present anisotropic model, the influences of the thermal conductivity ratio (TCR) and porosity of the foams on the anisotropic ratios of ETCs are also investigated. Results show that there is good consistency between the ETCs obtained by the anisotropic model and the numerical method. The maximum relative errors between them are 2.84% and 13.57% when TCRs are 10 and 100, respectively. The present anisotropic model can not only predict the ETCs in different orthogonal directions but also quantitatively predict the anisotropy of ETC. The anisotropies of the ETCs decrease with porosity because the proportion of the foam skeleton decreases. However, the anisotropies of ETCs increase with TCR, and there exist asymptotic values in anisotropic ratios of ETCs as TCR approaches infinity and they are equal to the relative Feret diameters in different orthogonal directions.

Background: HBeAg-positive chronic infection is a unique phase of chronic hepatitis B virus (HBV) infection. Current guidelines advise against starting antiviral treatment for HBeAg-positive chronic hepatitis B virus (HBV) infection patients, some data suggest treating such patients may reduce the risk of hepatocellular carcinoma. We aimed to explore whether these patients can have evident histological liver injury (EHLI), and develop a non-invasive model for identifying EHLI in such patients. Method: We assessed whether HBeAg-positive chronic HBV infection patients can have EHLI defined by Ishak fibrosis stage ≥3 and/or histologic activity index ≥ 9 in a prospective multicenter study. Logistic and Lasso regression was used to select the optimal predictors. We used Akaike information criterion, discrimination improvement, net reclassification improvement to develop and validate models predicting EHLI risk in training cohort and two external validation cohorts. Findings: Of these 336 patients met the inclusion criteria, 181(54%) were HBeAg-positive chronic HBV infection, of whom 60 patients (33%) had EHLI, the proportion of significant fibrosis was higher than that of significant inflammation (33% vs. 8%, P

High-enthalpy dissociating aerodynamic environment during high-speed spacecraft entries brings new challenges to the prediction of heat transfer characteristics on the surface of thermal protection system. This study numerically dealt with the coupling modeling of chemically reacting interface in carbon-oxygen dissociating environment in order to accurately and reliably predict the Mars entry heating load. Computational fluid dynamics, computational heat transfer and interface balance with proper coupling strategy were involved in the coupling algorithm to take into account the surface catalysis, material ablation and structural thermal response. Numerical simulation shows that the interfacial reaction model has influences on coupling evolution by exchanging various patterns of heat transfer on the interface, including that from temperature gradient, that caused by chemical reaction, and that carried by the injection kinetic energy. The types and energy barriers of interfacial reaction were found to change the aerodynamic heating enhancement and its evolution over coupling time, which is the most remarkable difference from the perfect gas result. Gas-solid interaction involving interfacial reaction exhibits three distinct temporal intervals: the initial, developing and fully developed stages, and the chemical dynamics and heat transfer characteristics vary at different temporal scales. Related research provides important technical support for the design of thermal protection system for space vehicles.

Mega electronvolt ion implantation and subsequent annealing were used to reduce crystalline disorders in molecular beam epitaxy GaAs films on Si. Results show that the success of the recrystallization process relies on the proper selection of the ion beam dose and energy. Further experimentation showed that complete recrystallization with improved quality is possible through proper implantation and subsequent annealing. The improved layers displayed defect densities that were lower than the amorphous-grown layers, particularly near the interface.

Background: Chronic hepatitis B (CHB) can progress to cirrhosis, hepatocellular carcinoma (HCC) and ultimately liver-related death. Although oral antiviral therapy for patients with CHB reduces the risk of such complications, once cirrhosis is established, the benefits of antiviral therapy are not robustly demonstrated. According to traditional Chinese medicine (TCM), some Chinese herbal medicines promote blood circulation and soften hard masses, and therefore they may block and reverse hepatic fibrosis. The aim of this study is to evaluate the effects of TCM tablets of the compound biejia ruangan (RGT) administered for fibrosis, and entecavir (ETV), on the development of HCC in patients with CHB or hepatitis B virus (HBV)-related compensated cirrhosis. Methods/design: This multicenter, centrally randomized, double-blind, placebo-controlled, parallel-group study is planned to complete within 5 years. For the study, 1,000 with CHB or HBV-related compensated cirrhosis are randomly assigned in a 1:1 ratio to a treatment group (0.5 mg ETV once daily; 2 g RGT three times daily) or a control group (0.5 mg ETV once daily; 2 g RGT dummy agent three times daily). The primary end points are the development of HCC and liver-related death. Secondary end points include disease progression and overall survival. Discussion: Although antiviral therapy can achieve sustained suppression of HBV replication, thereby preventing cirrhosis, patients with CHB treated with nucleos(t)ide analogs (NUCs) retain a higher risk for HCC compared with patients with inactive disease. Although previous clinical trials with RGT have confirmed the efficacy of blocking and reversing hepatic fibrosis in patients with CHB or compensated cirrhosis, the long-term risk for HCC or disease progression in these patients treated with combination of RGT and NUCs compared with NUCs alone is unclear. Therefore, it is necessary to investigate the effects of the RGT blockade and reversal of hepatic fibrosis on the development of HCC in patients with CHB or HBV-related compensated cirrhosis in large, prospective, multicenter, double-blind, randomized, controlled trials in China. [ABSTRACT FROM AUTHOR]

Surface chemical effects have great influence on the prediction of hypersonic nonequilibrium aerodynamic heating, and they are particularly complex in a dissociated carbon-oxygen environment for the possible use of Mars entry simulation. To clearly characterize the thermochemical behaviors and precisely predict the surface heat fluxes, a finite-rate surface chemical model involving the catalysis and ablation effects is developed, and the influences of catalysis, ablation, and their interaction on aerodynamic heating are parametrically discussed in detail. The computation finds that the surface thermochemical characteristics are dominated commonly by surface reactions and near-wall diffusion, depending on the balance of the levels of the chemical-reaction rate and the diffusional transport speed. The findings of this study indicate that both competition and enhancement exist between various surface reaction channels. They will compete for the species if they commonly consume the same reactant, whereas they will mutually enhance their heat fluxes if the product of one reaction channel supplies to the other. The surface chemical effects on aerodynamic heating can make assessments for the search and application of promising and profitable thermal protection materials based on the material catalytic and ablative characteristics in the scope of decreasing the weight of the thermal protection system. [ABSTRACT FROM AUTHOR]