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2. Highly selective hydroformylation of long-chain alkenes in a supercritical fluid ionic liquid biphasic systemThis paper was published as part of the themed issue of contributions from the Green Solvents – Alternative Fluids in Science and Application conference held in Berchtesgaden, October 2010.Dedicated to the memory of Dr Thulani Kunene who died tragically. A fine scientist and a good man. An obituary is provided as a supplementary file.
- Author
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KuneneDeceased December 2010., Thulani E., Webb, Paul B., and Cole-Hamilton, David J.
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HYDROFORMYLATION , *ALKENES , *SUPERCRITICAL fluids , *IONIC liquids , *RHODIUM catalysts , *ALDEHYDES , *LIGANDS (Chemistry) , *SOLUTION (Chemistry) , *IMIDAZOLES , *PHOSPHINE - Abstract
Continuous-flow rhodium-catalysed hydroformylation of long chain alkenes has been achieved with selectivities to the desired linear aldehyde of 92% and minimum rhodium loss, using a xantphos-derived ligand attached to an imidazolium salt in a supercritical fluid–ionic liquid system. The effect of oxygen in the system can be ameliorated to some extent by adding a simple sulfonated triphenylphosphine to the catalytic solution. [ABSTRACT FROM AUTHOR]
- Published
- 2011
3. Complete dissolution and partial delignification of wood in the ionic liquid 1-ethyl-3-methylimidazolium acetateThis paper was published as part of the themed issue of contributions from the Green Solvents - Progress in Science and Application conference held in Friedrichshafen, September 2008.Electronic supplementary information (ESI) available: Fig. S1–4. See DOI: 10.1039/b822702k
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Sun, Ning, Rahman, Mustafizur, Qin, Ying, Maxim, Mirela L., Rodríguez, Héctor, and Rogers, Robin D.
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SOLVATION , *WOOD chemistry , *IONIC liquids , *LIGNINS , *ACETATES , *IMIDAZOLES , *SUSTAINABLE chemistry , *HARDWOODS - Abstract
Both softwood (southern yellow pine) and hardwood (red oak) can be completely dissolved in the ionic liquid 1-ethyl-3-methylimidazolium acetate ([C2mim]OAc) after mild grinding. Complete dissolution was achieved by heating the sample in an oil bath, although wood dissolution can be accelerated by microwave pulses or ultrasound irradiation. It has been shown that [C2mim]OAc is a better solvent for wood than 1-butyl-3-methylimidazolium chloride ([C4mim]Cl) and that variables such as type of wood, initial wood load, particle size, etc.affect dissolution and dissolution rates; for example, red oak dissolves better and faster than southern yellow pine. Carbohydrate-free lignin and cellulose-rich materials can be obtained by using the proper reconstitution solvents (e.g., acetone/water 1 : 1 v/v) and approximately 26.1% and 34.9% reductions of lignin content in the reconstituted cellulose-rich materials (from pine and oak, respectively) have been achieved in one dissolution/reconstitution cycle. The regenerated cellulose-rich materials and lignin fractions were characterized and compared with the original wood samples and biopolymer standards. For pine, 59% of the holocellulose (i.e., the sum of cellulose and hemicellulose) in the original wood can be recovered in the cellulose-rich reconstituted material; whereas 31% and 38% of the original lignin is recovered, respectively, as carbohydrate-free lignin and as carbohydrate-bonded lignin in the cellulose-rich material. [ABSTRACT FROM AUTHOR]
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- 2009
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4. Synthesis and properties of glycerylimidazolium based ionic liquids: a promising class of task-specific ionic liquidsThis paper was published as part of the themed issue of contributions from the Green Solvents - Progress in Science and Application conference held in Friedrichshafen, September 2008.
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Bellina, Fabio, Bertoli, Alessandra, Melai, Bernardo, Scalesse, Francesca, Signori, Francesca, and Chiappe, Cinzia
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ORGANIC synthesis , *IONIC liquids , *IMIDAZOLES , *CATIONS , *SUSTAINABLE chemistry , *GLYCERIN , *CATALYSIS , *PALLADIUM catalysts - Abstract
A series of task-specific ionic liquids (TSILs) based on glycerylimidazolium cations have been prepared by reaction of 1-chloropropanediol, a compound obtainable from glycerol (a widely available and in-expensive waste product), with the appropriate base (1-H-imidazole, 1,2-dimethylimidazole and 1-methyl-1-H-imidazole). The reaction of 3-(1H-imidazol-1-yl)propane-1,2-diol with chloroalkanes, bromoalkanes and alkyl mesylates gave the corresponding salts which were characterized. The possibility to use these ILs in palladium catalyzed reactions was evaluated, evidencing good catalyst stability and a high recyclability. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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5. Synthesis and structural studies of metallamacrotricycles based on a metacyclophane in 1,3-alternate conformation bearing four imidazolyl unitsThis paper is dedicated to Professor Javier de Mendoza on the occasion of his 65th birthday.CCDC reference numbers 702193–702201. For crystallographic data in CIF or other electronic format see DOI: 10.1039/b816053h
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Ehrhart, Jérôme, Planeix, Jean-Marc, Kyritsakas-Gruber, Nathalie, and Hosseini, Mir Wais
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CYCLOPHANES , *CONFORMATIONAL analysis , *IMIDAZOLES , *METAL complexes , *X-ray diffraction , *CHEMICAL structure , *COMPLEX compounds synthesis , *MACROCYCLIC compounds - Abstract
The combination of a [1111]metacyclophane blocked in 1,3-alternate conformation and bearing four imidazole units with MX2(M = Co, Cu, Zn and Hg; X = Cl or Br) complexes leads to the formation of a series of analogous neutral metallamacrotricycles. In all cases, the structure of the binuclear complexes has been studied by X-ray diffraction methods on single crystals. [ABSTRACT FROM AUTHOR]
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- 2009
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6. Phosphabarrelene-modified Rh-catalysts: a new and selective route towards hydroxy-functionalized bicyclic imidazoles viatandem reactionsThis article is part of a ChemComm ‘Catalysis in Organic Synthesis’ web-theme issue showcasing high quality research in organic chemistry. Please see our website (http://www.rsc.org/chemcomm/organicwebtheme2009) to access the other papers in this issue.Electronic supplementary information (ESI) available: A list of all experimental details. CCDC reference number 736069. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/b911612e
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Bäuerlein, Patrick S., Gonzalez, Ismael Arenas, Weemers, Jarno J. M., Lutz, Martin, Spek, Anthony L., Vogt, Dieter, and Müller, Christian
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PYRIDINE , *RHODIUM catalysts , *IMIDAZOLES , *ORGANIC reaction mechanisms , *HYDROFORMYLATION , *RING formation (Chemistry) , *ORGANIC synthesis - Abstract
8-Hydroxy-6-methyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine was formed selectively in high yields from N-(β-methallyl)imidazole by a tandem hydroformylation–cyclization sequence, representing a novel one-pot catalytic synthesis of bicyclic imidazole derivatives. [ABSTRACT FROM AUTHOR]
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- 2009
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7. Rhodium catalyzed enantioselective cyclization of substituted imidazoles viaCâH bond activationThis article is part of a ChemComm âCatalysis in Organic Synthesisâ web-theme issue showcasing high quality research in organic chemistry. Please see our website http:www.rsc.orgchemcommorganicwebtheme2009 to access the other papers in this issue.Electronic supplementary information (ESI) available: Experimental details, analytical data, HPLC chromatograms, NMR spectra, and X-ray crystallographic data. CCDC 727522. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/b902878a
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Tsai, Andy S., Wilson, Rebecca M., Harada, Hitoshi, Bergman, Robert G., and Ellman, Jonathan A.
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RHODIUM catalysts , *RING formation (Chemistry) , *IMIDAZOLES , *HYDROGEN bonding , *ACTIVATION (Chemistry) , *ORGANIC synthesis , *ENANTIOMERS - Abstract
The enantioselective intramolecular alkylation of substituted imidazoles with enantiomeric excesses up to 98 has been accomplished by rhodium catalyzed CâH bond functionalization with S,Sâ²,R,Râ²TangPhos as the chiral ligand. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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8. A novel symmetrical imidazole-containing framework as a fluorescence sensor for selectively detecting silver ions.
- Author
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Wang, Junjie, Lan, Zhenni, Hou, Shili, and Hou, Shifeng
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SILVER ions ,FLUORESCENCE ,IMIDAZOLES ,DETECTORS ,STANDARD deviations ,WATER testing - Abstract
In this study, a novel and highly efficient "turn-off" fluorescence imidazole-based sensor (BIB) with a symmetric structure was synthesized by a four-step reaction, from o-phenylenediamine, 6-bromo-2-pyridinecarboxaldehyde, and 1-bromohexane. The sensing mechanism was confirmed via fluorescence titration, HRMS, and
1 HNMR techiniques. The results showed that the binding ratio of BIB and Ag+ was 1 : 1 in a DMF-HEPES (pH 7.4) solution (9 : 1, v/v). The fluorescence response of BIB exhibited a good linear response within the Ag+ concentration ranging from 2 × 10−7 to 8 × 10−6 mol L−1 , and the limit of detection was calculated to be 4.591 × 10−8 mol L−1 . BIB was successfully applied to the detection of Ag+ in water samples with recoveries of 97.25–109.50% and relative standard deviations (RSD) of 1.14–2.45%. In addition, BIB can successfully be applied to qualitatively and quantitatively identify Ag+ in water by test paper strips of BIB, which is fast and convenient. This provides a possible potential for the rapid monitoring of metal ions by sensors in environmental research. [ABSTRACT FROM AUTHOR]- Published
- 2021
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9. Design and synthesis of functionalized defective MOFs for catalytic conversion of CO2 to cyclic carbonates under green conditions.
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Liu, Xueting, Cui, Shasha, Li, Kuayue, Liu, Wenkui, Cui, Peng, and Wei, Fengyu
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RING formation (Chemistry) ,LEWIS acidity ,MONOCARBOXYLIC acids ,CARBONATES ,TEREPHTHALIC acid ,IMIDAZOLES - Abstract
In this paper, the functionalized ligand 2-(imidazole-1-yl)terephthalic acid was obtained by grafting an imidazole group onto 2-bromoterephthalic acid. Then, defective MOFs were synthesized with Hf ions and the ligand in the presence of monocarboxylic acid acting as a modulator, and NHC (nitrogen heterocyclic carbene)–CO
2 adducts were grafted onto the Hf-based MOFs to catalyze the cycloaddition reaction of epoxides with CO2 to produce cyclic carbonates under green conditions of ambient pressure and being solvent- and cocatalyst-free. The mesopore defects created by the modulator and DMC (dimethyl carbonate) solvothermal etching, the enhanced Lewis acidity of the Hf clusters and the grafted NHC–CO2 adducts can improve synergistically the catalytic performance of the MOFs via decreasing activation energy, promoting mass transfer and providing more active catalytic sites. The results show that the highest conversion rate reaches 81.64% at 100 °C and 10 h for the cycloaddition reaction of CO2 with epichlorohydrin. Finally, a possible reaction mechanism was proposed based on characterization and catalytic measurement. [ABSTRACT FROM AUTHOR]- Published
- 2023
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10. New Hg(II) coordination polymers based on a thioimidazole ligand with good performance to detoxify Hg(II) and reversibly capture iodine.
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Bahrani-Pour, Maryam, Beheshti, Azizolla, Sedaghat, Tahereh, Hoveizi, Elham, Naseri, Nadieh, Mayer, Peter, and Centore, Roberto
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COORDINATION polymers ,THIOAMIDES ,IMIDAZOLES ,X-ray crystallography ,CATIONIC polymers ,IODINE ,LIVER cells ,SINGLE crystals - Abstract
In the current paper, we have successfully synthesized three new mercury coordination polymers with fascinating structures and properties via a flexible sulfur donor ligand, namely, {[Hg(μ
2 -Cl)(μ2 -Ls)]}n [BF4 ]n (1), {[Hg(μ2 -Cl)(μ2 -Ls)]}n [ClO4 ]n (2), and [Hg(SCN)2 (μ2 -Ls)]n (3) [Ls = 1,1-bis(3-methyl-4-imidazoline-2-thione)methane]. These complexes have been characterized by means of different techniques such as single crystal X-ray crystallography, FT-IR, elemental analysis (CHNS), UV-Vis, PXRD, BET, and TGA. Suitable single crystals of all complexes were obtained using the branch tube method with a very high yield and good stability due to the high affinity of mercury to bind to the thione groups. The cationic moieties of polymers 1 and 2 were isostructural, with a HgCl2 S2 coordination core structure. The voids of the quasi-hexagonal packing of the columnar chains were occupied by unbonded tetrahedral BF4 − ions in 1 and perchlorate anions in polymer 2. Polymer 3 has a less distorted tetrahedral geometry than 1 and 2, with a HgS4 core structure. By considering the thiophilicity of mercury, a thioamide-based Ls ligand was used to detoxify Hg(II) into insoluble polymers 1–3. The results of an MTT assay for (HepG2) liver cells confirmed the excellent cytoprotective effect of this ligand against mercury. Based on IC50 calculations, their toxicity was in order of polymer 1 > polymer 2 > polymer 3. These polymers were also considered as adsorbents for the reversible removal of iodine from solution and the kinetics of the process has been studied in detail. Interestingly, all of them showed an excellent stability and high capacity, in order of 763.53 mg g−1 , 877.10 mg g−1 , and 905.31 mg g−1 for polymers 1–3, respectively. [ABSTRACT FROM AUTHOR]- Published
- 2023
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11. Insensitive nitrogen-rich compounds with a planar 2D configuration based on an imidazole–tetrazole.
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Qin, Yaqi, Yang, Feng, Xu, Yuangang, Wang, Pengcheng, Lin, Qiuhan, and Lu, Ming
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FURAZANS ,TETRAZOLES ,IMIDAZOLES ,NITROGEN compounds ,STRUCTURAL stability ,INTEGRATED software - Abstract
Nowadays, nitrogen rich compounds are the key research objects for high-energy materials. In this paper, a novel nitrogen rich energetic compound (NABTI) and its salt (4) with bis(tetrazole)imidazole as the skeleton were synthesized by simple steps. Their detailed structural data and stability parameters were obtained through experiments, and the internal relationship between them was theoretically analyzed. The results show that they both have regular planar configurations and layer-by-layer packing patterns, and the 3D hydrogen-bonding network and π–π interactions inside the crystals weaken their sensitivity to mechanical stimuli. As the most direct parameter reflecting the energy level, the detonation velocity (D) and detonation pressure (P) of the compounds in the study were calculated through the EXPLOV5 software package. The calculation results showed that NABTI exhibited a better detonation performance (D = 8329 m s
−1 and P = 31.4 GPa) than the same type (triazole–tetrazole, NATT) of compound. The advantages of NABTI, such as high nitrogen content, high energy and simple synthesis, fully demonstrate its practicality. [ABSTRACT FROM AUTHOR]- Published
- 2022
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12. Excited-state intramolecular proton-transfer solid-state fluorophores with aggregation-induced emission as efficient emitters for electroluminescent devices.
- Author
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Petdee, Sujinda, Chantanop, Nuttapong, Arunlimsawat, Suangsiri, Saenubol, Atthapon, Nalaoh, Phattananawee, Sudyoadsuk, Taweesak, and Promarak, Vinich
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ELECTROLUMINESCENT devices ,INTRAMOLECULAR proton transfer reactions ,STOKES shift ,FLUOROPHORES ,LIGHT emitting diodes ,QUANTUM efficiency ,IMIDAZOLES - Abstract
Excited-state intramolecular proton transfer (ESIPT) materials have emerged as highly promising candidates for emitters in organic light-emitting diodes (OLEDs), attributed to their distinctive photophysical properties. These materials have garnered considerable attention due to their pronounced Stokes shifts, exceptional color purity, and potential for achieving high efficiency and stability in OLED applications. To develop highly luminescent solids with large Stokes shifts, two imidazole-based ESIPT-AIE emitters, PPy-HPI and PPy-HPIC, have been synthesized following the strategy of combining excited-state intramolecular proton transfer (ESIPT) and aggregation-induced emission (AIE) systems. These emitters integrate the ESIPT cores 2-(2-hydroxy-5-methylphenyl)-1,4,5-triphenylimidazole (HPI) and 2-(2-hydroxy-5-methylphenyl)-1- phenylphenanthroimidazole (HPIC) with the AIE-active luminogen 4-(1-phenylvinyl)pyridine (PPy). The ESIPT and AIE properties were confirmed through both theoretical and experimental studies. The emitters demonstrated ESIPT and AIE characteristics, featuring a large Stokes shift and strong yellow-green to yellow emission in the solid state, which originated from the pure keto form. A non-doped OLED utilizing PPy-HPIC demonstrated yellow emission with CIE coordinates of (0.47, 0.51), a maximum external quantum efficiency (EQE
max ) of 3.13% and a maximum current efficiency (CEmax ) of 9.48 cd A-1 . Notably, the non-doped OLED incorporating PPy-HPI exhibited yellow-green emission with CIE coordinates of (0.15, 0.10), EQEmax of 3.61%, and CEmax of 10.56 cd A-1 , with minimal efficiency roll-off. These results signify a major breakthrough in creating ESIPT molecules for use as non-doped emitters in fluorescent OLEDs. [ABSTRACT FROM AUTHOR]- Published
- 2024
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13. Effervescent tablet-enhanced acidic ionic liquid-assisted in situ solvent formation magnetic solid-phase extraction for the detection of three phenolic pesticides in four kinds of crop flour samples.
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Bian, Chang, Liu, Yu, Li, Zhenghao, Wang, Xuedong, and Gao, Ming
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SOLID phase extraction ,FLOUR ,TABLETING ,SOLVENTS ,CROPS ,TRANSCRANIAL magnetic stimulation ,PESTICIDES ,IMIDAZOLES - Abstract
There are some notable drawbacks of ordinary magnetic effervescent tablets including their quick disintegration, hygroscopicity, and impracticability for field use. In order to solve the above problems for further extraction and preconcentration of three phenolic pesticides from crop flour samples, an effervescent tablet-assisted acidic ionic liquid-based in situ solvent formation magnetic solid-phase extraction (ETA-AIL-MSPE) technique was developed. In contrast to conventional imidazole ionic liquids, acidic ionic liquids can be employed as an acid source for effervescent processes in addition to being used as extractants. Not only does this reduce the need for organic solvents, but the production of CO
2 by the effervescent tablet also provides a rapid dispersion effect, removing the requirement for further dispersion stages and streamlining the experiment. The magnetic effervescent tablet is made of Na2 CO3 as an alkaline source, [BMIM][HSO4 ] as extractant and acidic sources, NaCl as a viscosity modifier, and Fe3 O4 as magnetic nanoparticles. The Plackett–Burman design and the central composite design were used to screen and optimize three key variables (93 mg of Na2 CO3 , 451 mg of AIL, and 37 mg of Fe3 O4 ), respectively. Through the integration of high-performance liquid chromatography-diode array detection (HPLC-DAD), the ETA-AIL-MSPE technique provided enhanced recoveries of 85.0–107.2% and limits of detection of 0.14–0.17 μg kg−1 for three representative species (ioxynil, bromoxynil, and dinoseb) in four different types of crop flour samples. For both intra-day and inter-day precision, the relative standard deviations were below 7.7%. Generally, the recently developed technique is convenient, efficient and environmental-friendly, and it has great potential for on-site sample preparation for the detection of phenolic pesticides in crop flour samples. [ABSTRACT FROM AUTHOR]- Published
- 2024
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14. A new imidazole based phenanthridine probe for ratiometric fluorescence monitoring of methanol in biodiesel.
- Author
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Sawminathan, Sathish and Iyer, Sathiyanarayanan Kulathu
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PHENANTHRIDINE ,METHANOL ,FLUORESCENCE ,EMISSION spectroscopy ,IMIDAZOLES ,ORGANIC solvents - Abstract
We prepared and characterized an array of polarity-sensitive fluorescent dyes (7 and 9a, 9b and 9c). Fluorescent dyes are based on imidazole cores, suitably functionalized with a conjugated push–pull system. The photophysical properties of the synthesized materials were elaborately investigated. These new fluorescent probes showed good fluorecence emission, higher φ
Fl values and large Stokes shifts in different organic solvents because of their ICT nature. Furthermore, with aldehyde groups as the recognition sites, all the dyes could act as ratiometric fluorescent sensors towards methanol. The selective ratiometric fluorescence response towards methanol is due to the strong intermolecular H-bonding between the aldehyde unit and methanol. The detection limit of methanol was found to be at the ppm level. Methanol sensing was confirmed using emission spectroscopy, FTIR studies and theoretical calculations. Additionally, these dyes were used for the detection of methanol in biodiesel and in test paper strips. [ABSTRACT FROM AUTHOR]- Published
- 2021
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15. Reactions of cyclonickelated complexes with hydroxylamines and TEMPO˙: isolation of new TEMPOH adducts of Ni(II) and their reactivities with nucleophiles and oxidants.
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Sarker, Rajib K. and Zargarian, Davit
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NUCLEOPHILES ,OXIDIZING agents ,MORPHOLINE ,ACETONITRILE ,IMIDAZOLES - Abstract
This contribution describes a study on the reactivities of the complexes [{κP,κC-(i-Pr)
2 PO-Ar}Ni(μ-Br)]2 , 1a–d (Ar: C6 H4 , a; 3-Cl-C6 H3 , b; 3-OMe-C6 H3 , c; 4-OMe-napthalenyl, d), with hydroxylamines in the presence of TEMPO˙ (TEMPO˙ = (2,2,6,6-tetramethylpiperidinyl-1-yl)oxyl). The results of this study showed that treating 1a–d with a mixture of Et2 NOH and TEMPO˙ did not afford the desired oxidation-induced functionalization of the Ni-aryl moiety in 1a–d, giving instead the corresponding κO-TEMPOH adducts [{κP,κC-(i-Pr)2 PO-Ar}Ni(Br)(κO-TEMPOH)], 3a–d (TEMPOH = N-hydroxy-2,2,6,6-tetramethylpiperidine). The TEMPOH moiety in these zwitterionic compounds 3 can be displaced by a large excess of acetonitrile (MeCN), 10 equiv. of morpholine, or 1–2 equivalents of imidazole. Although these reactions have given the authenticated products [{κP,κC-(i-Pr)2 PO-C6 H4 }Ni(Br)(NCMe)], 4a, [{κP,κC-(i-Pr)2 PO-C6 H4 }Ni(Br)(morpholine)], 5a, and [{κP,κC-(i-Pr)2 PO-C6 H4 }Ni(imidazole)2 ]Br, 6a, a few other products were also detected by NMR, indicating that the observed reactivities are far more complex than simple substitution of the TEMPOH moiety. Similarly, treating 3a with AgOC(O)CF3 results in the isolation of [{κP,κC-(i-Pr)2 PO-C6 H4 }Ni{OC(O)CF3 }(κO-TEMPOH)], 7a, arising from the substitution of the bromo ligand, whereas spectroscopic evidence suggests further reactivity, possibly including displacement of TEMPOH and oxidative decomposition. [ABSTRACT FROM AUTHOR]- Published
- 2024
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16. Enhanced selectivity towards melanoma cells with zinc(II)-Schiff bases containing imidazole derivatives.
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Côrte-Real, Leonor, Sergi, Baris, Yildirim, Busra, Colucas, Raquel, Starosta, Radosław, Fontrodona, Xavier, Romero, Isabel, André, VÃnia, Acilan, Ceyda, and Correia, Isabel
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SCHIFF bases ,DOUBLE-strand DNA breaks ,TRIPLE-negative breast cancer ,COORDINATION polymers ,MELANOMA ,ZINC ,CANCER cells ,IMIDAZOLES - Abstract
Zinc(II)-complexes with the general formula [Zn(L)
2 ] containing 8-hydroxyquinoline Schiff bases functionalized with 1-(3-aminopropyl)imidazole or 1-(3-aminopropyl)-2-methyl-1H-imidazole on 2-position and their respective ligands (HL1 or HL2 ) were synthesized and characterized by NMR, UV-Vis, FTIR and CD spectroscopies as well as ESI-MS spectrometry. Single crystals of HL2 and [Zn(L1 )2 ]n were analysed by SC-XRD. [Zn(L1 )2 ]n shows a 1D polymeric chain structure of alternating Zn(II) cations and bridging Schiff base ligands, in contrast to previously reported monomeric structures of analogous complexes. DFT calculations were performed to rationalize the polymeric X-ray structure of Zn(L1 )2 . Results showed that the ligands can bind as bi- or tridentate to Zn(II) and there is the possibility of a dynamic behavior for the complexes in solution. Both ligands and complexes present limited stability in aqueous media, however, in the presence of bovine serum albumin the complexes are stable. Molecular docking simulations and circular dichroism spectroscopic studies suggest binding to this protein in close proximity to the Trp213 residue. Biological studies on a panel of cancer cells revealed that the Zn(II)-complexes have a lower impact on cell viability than cisplatin, except for triple-negative breast cancer cells in which they were comparable. Notwithstanding, they display much higher selectivity towards cancer cells vs. normal cells, than cisplatin. They induce the generation of ROS and DNA double-strand breaks, primarily through apoptosis as the mode of cell death. Overall, the novel Zn(II)-complexes demonstrate improved induction of apoptosis and higher selectivity, particularly for melanoma cells, compared to previously reported analogues, making them promising candidates for clinical application. [ABSTRACT FROM AUTHOR]- Published
- 2024
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17. Experimental and theoretical studies of pH-responsive iridium(III) complexes of azole and N-heterocyclic carbene ligands.
- Author
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Hashemzadeh, Tahmineh, Christofferson, Andrew J., White, Keith F., and Barnard, Peter J.
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IRIDIUM ,PHOSPHORESCENCE ,PROTON transfer reactions ,PHOTOLUMINESCENCE ,IMIDAZOLES ,VOLUMETRIC analysis ,BENZIMIDAZOLES ,PALLADIUM compounds - Abstract
A series of nine luminescent iridium(III) complexes with pH-responsive imidazole and benzimidazole ligands have been prepared and characterized. The first series of complexes were of the form [Ir(ppy)
2 (N^N)]+ or [Ir(ppy)2 (C^N)]+ (where ppy is 2-phenylpyridine and N^N is 2-(2-pyridyl)imidazole or 2-(2-pyridyl)benzimidazole and C^N represents a pyridyl-triazolylidene-based N-heterocyclic carbene ligand). For these complexes, the benzimidazole group was either unsubstituted or substituted with electron-withdrawing (Cl) or electron-donating (Me) groups. The second series of complexes were of the form [Ir(phbim)2 (N^N)]+ or [Ir(phbim)2 (C^N)]+ (where phbim is 2-phenylbenzimidazole and N^N is either 2,2′-bipyridine or 1,10-phenanthroline and C^N is either a pyridyl-imidazolylidene or pyridyl-triazolylidene N-heterocyclic carbene ligand). UV-visible and photoluminescence pH titration studies showed that changing the protonation state of these complexes results in significant changes in the photoluminescence emission properties. The pKa values of prepared complexes were estimated from the spectroscopic pH titration data and these values show that the nature of the pH-sensitive ligands (either main or ancillary ligands) resulted in a significant capacity to modulate the pKa values for these compounds with values ranging from 5.19–11.22. Theoretical investigations into the nature of the electronic transitions for the different protonation states of compounds were performed and the results were consistent with the experimental results. [ABSTRACT FROM AUTHOR]- Published
- 2024
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18. Novel fused pyran derivatives induce apoptosis and target cell cycle progression in anticancer efficacy against multiple cell lines.
- Author
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Fabitha, K., Kallingal, Anoop, Maciejewska, Natalia, Arya, C. G., Chandrakanth, Munugala, Thomas, Neethu Mariam, Li, Yupeng, Gondru, Ramesh, Munikumar, Manne, and Banothu, Janardhan
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CELL cycle ,PYRAN derivatives ,BENZOTRIAZOLE derivatives ,ANTINEOPLASTIC agents ,CELL lines ,DOUBLE-strand DNA breaks ,BENZIMIDAZOLES ,IMIDAZOLES - Abstract
Nitrogen-based heterocycles such as pyrazole, imidazole, 1,2,4-triazole, benzimidazole, and benzotriazole substituted fused pyran derivatives (6a–e, 8a–e, 10a–e, 12a–e, & 14a–e) have been synthesized and tested for their in vitro anticancer efficacies against MCF7, A549, and HCT116 cancer cell lines. Among the compounds, 6e, 14b, and 8c were identified as the most potent against MCF7, A549, and HCT116, with IC
50 values of 12.46 ± 2.72 μM, 0.23 ± 0.12 μM, and 7.58 ± 1.01 μM, respectively. Further studies demonstrated that these compounds can change cellular and nuclear morphology and inhibit colony formation in the tested cancer cells. They also remarkably block/inhibit the cell cycle progression of cancer cells at various phases. DNA damage analysis and apoptosis studies revealed that these compounds have the potential to induce DNA double-strand breaks and apoptosis. In silico absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of the potent compounds were assessed, revealing that all the compounds exhibited favorable pharmacokinetic and toxicological properties. The potent compounds identified from this study can be considered as a lead for further drug design and development. [ABSTRACT FROM AUTHOR]- Published
- 2024
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19. Self-assembled superstructures derived from suitably substituted phenanthro[9,10-d] imidazole-based Zn(II)/Cd(II) complexes for selective detection of acetone.
- Author
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Siva, Mallayasamy, Sasi, Sheethal, Rana, Priya, Bera, Raj Kumar, Sivalingam, Yuvaraj, and Das, Priyadip
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SURFACE photovoltage ,VOLATILE organic compounds ,ACETONE ,GAS detectors ,MOLECULAR probes ,SMART materials ,IMIDAZOLES - Abstract
The design and development of smart materials in developing advanced sensing platforms for volatile organic compounds (VOCs) have attracted increasing attention. π-Conjugated small organic building blocks, which can self-assemble into well-ordered superstructures, offer multiple advantages of high surface area, unique optoelectronic properties, good chemical/thermal stability, and host–guest interaction ability, which make them appealing candidates for VOC sensing. However, the fabrication of stable and well-ordered self-assembled structures from π-conjugated building blocks with appreciable electrical properties and their successful employment in the selective detection of VOCs remains a challenge due to the non-specific interaction between monomers during self-assembly and with other existing VOCs during sensing, respectively. Herein, we have designed and synthesized three phenanthro[9,10-d] imidazole-based ligands; L1, L2, and L3 with three different hydroxy benzene analog substitutions at the 2-position and their corresponding Zn(II) and Cd(II) complexes followed by fabrication into well-ordered superstructures with discrete morphologies for the selective detection of acetone vapour by measuring the contact potential difference using the Scanning Kelvin Probe (SKP). Several experimental analyses suggest that a precise combination of the operative non-covalent interactions along with the metal–ligand interactions drive the overall self-assembly process of these metal coordinated π-conjugated probes and could lead to generation of well-ordered various superstructures. Surface photovoltage measurements using the SKP on the surfaces of films coated with superstructures derived from these metal complexes were carried out both in the dark and under UV (Ultra-Violet) illumination in the presence of different vapours of VOCs. As per the results, under UV illumination, the thin film fabricated with superstructures derived from Cd complexes ((L1)
2 M, (L2)2 M and (L3)2 M; M = Cd(II)) exhibit higher sensitivity and selectivity towards acetone in comparison with Zn(II) complexes-based superstructures. Thus, these self-assembled structures generated by the metal complexes of these π-conjugated molecular probes may provide new insights into the fabrication of organic electronic devices for gas sensors. [ABSTRACT FROM AUTHOR]- Published
- 2024
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20. Nanopolyhedral Zn/Fe-NC derived from bimetallic zeolitic imidazole frameworks as an efficient catalyst for the oxygen reduction reaction in an air-cathode microbial fuel cell.
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Wang, Qianwu, Lu, Jingzhao, Liu, Songlin, Yu, Boqu, and Liang, Bolong
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MICROBIAL fuel cells ,OXYGEN reduction ,IMIDAZOLES ,CATALYSTS ,CATALYTIC activity ,DOPING agents (Chemistry) - Abstract
The development of carbon-based catalysts to substitute Pt-based catalysts for the oxygen reduction reaction is highly important for promoting their practical application in energy conversion. Herein, we prepare Zn, Fe and N-codoped porous carbon (Zn/Fe-NC-x) as a cathode catalyst via a facile one-step pyrolysis predesigned bimetallic zeolitic imidazole framework. Systematic electrochemical studies demonstrated that the synthesized Zn/Fe-NC-0.5 exhibits higher electrocatalytic activity towards the oxygen reduction reaction. In particular, Zn/Fe-NC-0.5 has a smaller charge transfer resistance, larger exchange current density, and much higher open circuit potential and mainly proceeds via an efficient four-electron pathway. A microbial fuel cell equipped with the synthesized catalyst exhibited the highest maximum power density of 1954 ± 20 mW m
−2 . In addition, the effects of the iron doping content on the oxygen reduction reaction performance and maximum power density were evaluated: a moderate Fe doping content plays a crucial role in improving the catalytic activity, and the synergistic effect of Zn, Fe and N codoping promotes cathodic performance. In brief, Zn/Fe-NC, which has the advantages of facile synthesis, environmental friendliness and excellent electrochemical activity, is a promising Pt-alternative catalyst for the oxygen reduction reaction in air-cathode microbial fuel cells. [ABSTRACT FROM AUTHOR]- Published
- 2024
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21. The nature of π-hole spodium bonds in the HgLCl2(L = pyrrole, pyrazole, imidazole, pyridine, pyridazine, and pyrimidine) complexes: from noncovalent to covalent interactions.
- Author
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Tian, Rong, Zeng, Yanli, Li, Xiaoyan, and Zhang, Xueying
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COORDINATE covalent bond ,PYRROLES ,PYRAZOLES ,PYRIMIDINES ,PYRIDINE ,IMIDAZOLES ,PYRIDAZINES - Abstract
The nature of π-hole spodium bonds in the HgLCl
2 ⋯ZH3 /CH2 Y complexes (L = pyrrole 1, pyrazole 2, imidazole 3, pyridine 4, pyridazine 5, and pyrimidine 6; Z = N, P, As, and Sb; Y = O, S, Se, and Te) has been studied using theoretical calculations. The electrophilicity of the π-hole in the tri-coordinated HgII complexes varies with the type of N-heterocyclic ligand. The strength and nature of the π-hole spodium bond is closely related to the properties of the Lewis bases. In the case of HgLCl2 ⋯ZH3 , the strength of the π-hole spodium bond weakens as the nucleophilicity of the base decreases, following the sequence HgLCl2 ⋯NH3 > HgLCl2 ⋯PH3 > HgLCl2 ⋯AsH3 > HgLCl2 ⋯SbH3 . The Hg⋯Z spodium bonds change from a partially covalent interaction to a close-shelled noncovalent interaction. The nucleophilic ability of CH2 Y decreases in the order CH2 O > CH2 S > CH2 Se > CH2 Te, while the strength of the π-hole spodium bond follows the order HgLCl2 ⋯OCH2 < HgLCl2 ⋯SCH2 < HgLCl2 ⋯SeCH2 < HgLCl2 ⋯TeCH2 . The Hg⋯Y spodium bond undergoes a transition from a close-shelled noncovalent to a partially covalent interaction, resulting in an incremental increase in the degree of covalence. The Hg⋯Te spodium bond exhibits certain characteristics resembling those of a coordinate covalent bond. The inter-orbital interactions observed in the formation of the HgLCl2 ⋯YCH2 complexes appear to be significantly stronger compared to those observed in the HgLCl2 ⋯ZH3 complexation. [ABSTRACT FROM AUTHOR]- Published
- 2024
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22. Synergic improvements in flame retardant and dielectric properties of hybrid epoxy resin composites bearing a dimethyl methylphosphonate-loaded zeolitic imidazole framework.
- Author
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Guan, Huiru, Liu, TingShu, Shi, Lifeng, Ma, Liwei, Kirillov, Alexander M., Liu, Weisheng, Yang, Lizi, and Dou, Wei
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FIREPROOFING agents ,DIELECTRIC properties ,EPOXY resins ,DIMETHYL methylphosphonate ,ENTHALPY ,DIELECTRIC loss ,IMIDAZOLES - Abstract
With a rapid expansion in applications of epoxy resins (EP) and derived composites, there is a high demand for improving their flame retardant and dielectric properties. In this work, a facile and convenient strategy for loading a dimethyl methylphosphonate (DMMP) flame retardant into the channels of ZIF-8 (zeolitic imidazolate framework) was developed, followed by the assembly of a hybrid ZIF-8@DMMP material with epoxy resin (EP). The obtained MOF-containing hybrid EP composites, abbreviated as 8
20 /EP (with 20 wt% ZIF-8) and 8 FR20 /EP (with 20wt% ZIF-8@DMMP), were fully characterized and shown to feature superior flame retardant behavior, contributing to an enhanced safety of such material in terms of total smoke suppression, lower levels of total heat release and carbon monoxide generation. The results demonstrated that the formation of an intumescent dense char layer restrained further combustion, thus enabling this composite material to feature a better flame retardant performance. Besides, the composite exhibited a dielectric permittivity and dielectric loss of as low as 3.0 at a high frequency, which significantly outperforms the neat epoxy resin. This work thus showcases a simple and efficient route to enhance dielectric and flame retardant properties of polymeric epoxy resins, while merging the inherent porosity of ZIF-8 and traditional flame retardant behavior of DMMP. [ABSTRACT FROM AUTHOR]- Published
- 2024
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23. Composition–property relationships of choline based eutectic solvents: impact of the hydrogen bond donor and CO2 saturation.
- Author
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Dikki, Ruth, Khokhar, Vaishali, Zeeshan, Muhammad, Bhattacharjee, Sanchari, Coskun, Oguz Kagan, Getman, Rachel, and Gurkan, Burcu
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CHOLINE chloride ,HYDROGEN bonding ,SOLVENTS ,ETHYLENE glycol ,EUTECTICS ,IMIDAZOLES ,CHOLINE - Abstract
Eutectic solvents are tunable for targeted applications through the functional groups in their hydrogen bond acceptor (HBA) and hydrogen bond donor (HBD) components, as well as the HBA : HBD composition ratio. This study examines the properties of choline-based eutectics containing imidazole, phenol, pyrrole-2-carbonitrile, and 1,2,4-triazole HBAs, and ethylene glycol, 1,2-propylene glycol, and ethanolamine HBDs. The viscosity, conductivity, degree of hydrogen bonding, thermal stability, and solvatochromic properties are examined as a function of HBA, HBD, and the composition. These studies revealed a predominant dependence of physical properties on the HBD and determined that the strong hydrogen bonding in phenol and imidazole-based systems lead to higher viscosities and lower conductivities – critical parameters for CO
2 capture and electrochemical conversion. The developed eutectic solvents were further evaluated in terms of their CO2 capture capacities and electrochemical stabilities. Solvatochromic properties were found to correlate with CO2 capacities, demonstrating the tunability of these solvents for CO2 capture. The quantitative structure–property relationship (QSPR) analysis demonstrated the ability to predict viscosities and CO2 capture capacities (<25% deviation) through a multi linear regression method utilizing five molecular descriptors. This work highlights the role of functionalized HBAs and HBDs in the physical, thermal, and electrochemical properties of eutectic solvents as they relate to CO2 capture and electrochemical processes. [ABSTRACT FROM AUTHOR]- Published
- 2024
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24. 4,5-Diiodo-1-H-imidazole-derived linker ligand and Cu(I) and Co(II) coordination polymers based thereupon.
- Author
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Zaguzin, Alexander S., Zaitsev, Artem V., Korobeynikov, Nikita A., Novikov, Alexander S., Usoltsev, Andrey N., Fedin, Vladimir P., and Adonin, Sergey A.
- Subjects
COORDINATION polymers ,COPPER ,BUTANE ,IMIDAZOLES - Abstract
A new iodine-rich imidazole derivative 1,4-bis(4,5-diiodo-1H-imidazol-1-yl)butane (bimbI
4 , 1) features multiple I⋯I interactions in the solid state. Using 1 as a precursor, we prepared 1D and 2D coordination polymers of Co(II) and Cu(I) – {[Co(bimbI4 )Cl2 ]·1.5DMF}n (2) and {[Cu2 I2 (bimbI4 )]}n (3), respectively, also featuring extended systems of halogen bonds within their structures. [ABSTRACT FROM AUTHOR]- Published
- 2024
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25. Polyoxometalate-based ionic liquids: efficient reversible phase transformation-type catalysts for thiolation of alcohols to construct C–S bonds.
- Author
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Li, Jikun, Ma, Junwei, Wei, Chuanping, Zheng, Zebao, Han, Yinfeng, Wang, Huiping, Wang, Xueshen, and Hu, Changwen
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IONIC liquids ,HETEROGENEOUS catalysts ,CATALYTIC activity ,CATALYSTS ,BENZYL alcohol ,IMIDAZOLES ,COUPLING reactions (Chemistry) - Abstract
As important building blocks in natural products and organic synthesis, thioethers have a wide range of potential applications. Herein, polyoxometalate-based ionic liquids (POM-ILs-SO
3 H) derived from N-alkyl imidazole were synthesized and used for the first time for the thiolation of alcohols to construct C–S bonds in a series of benzyl thioethers. This type of POM-ILs-SO3 H catalyst exhibited high catalytic activity, providing up to 98% yield of thioether within 1 h at 70 °C. The alkyl chain length of the imidazole had a certain effect on the solubility of the POM-ILs-SO3 H catalysts in the reaction solvent, and then affected their catalytic activity. The catalytic system had a wide substrate scope and was suitable for the reaction of tertiary and secondary benzyl alcohols with thiophenols or cycloalkyl thiols. In particular, [PIMPS]3 PW12 O40 (PIM = 1-propylimidazole, PS = propane sulfonate) as a reversible phase transformation-type catalyst, combining the advantages of homogeneous and heterogeneous catalysts, exhibited high activity and good recyclability with only a slight decrease in the yield after five runs. Additionally, a carbocation mechanism was proposed for the thiolation reaction of alcohols. [ABSTRACT FROM AUTHOR]- Published
- 2024
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26. Catalyst- and additive-free three-component construction of isoxazolidinyl nucleosides and azoles via 1,3-dipolar cycloaddition.
- Author
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Yuan, Xinyufei, Gao, Hang, Li, Xing, Zhang, Qin, Chen, Wenwen, and Wang, Hui
- Subjects
AZOLES ,DIAZO compounds ,NUCLEOSIDES ,RING formation (Chemistry) ,PYRIMIDINES ,IMIDAZOLES - Abstract
Environment-benign one-pot three-component cycloadditions of diazo compounds, nitrosoarenes and vinyl pyrimidines, or vinyl purines, or vinyl imidazoles, or vinyl triazoles or vinyl indole have been developed. This catalyst- and additive-free strategy could efficiently introduce the isoxazolidine skeleton into nucleoside analogues, oxazole molecules and indole derivatives to provide diverse classes of isoxazolidinyl pyrimidine nucleoside analogues, isoxazolidinyl purine nucleoside analogues, isoxazolidinyl imidazoles, isoxazolidinyl triazoles and isoxazolidinyl indole with moderate to good yields for most substrates. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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27. A new class of unique quinoidal-like imidazoliumyl tetrazinides: synthesis, structure, and mechanism.
- Author
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Geng, Yanxue, Sun, Weijun, Zhang, Weixu, Li, Mengyao, Wang, Guo, and Wang, Jianchun
- Subjects
COMPUTATIONAL chemistry ,CHEMICAL yield ,MASS spectrometry ,X-ray diffraction ,SOLVENTS ,IMIDAZOLES - Abstract
A series of 6-oxo-3-(1,2,4,5-substituted-1H-imidazol-3-ium-3-yl)-3,6-dihydro-1,2,4,5-tetrazin-3-ides (3a–3z, 3aa–3ak) was synthesized with medium to good yield by the reaction of 3,6-dichloro-1,2,4,5-tetrazine with a variety of substituted imidazoles in the presence of trace water in solvents. The quinoidal-like structure of these compounds was demonstrated via spectroscopic methods, X-ray diffraction techniques, and computational chemistry. Additionally, water–
18 O was used to prove that the oxygen in tetrazinone comes from the water in solvents via high-resolution mass spectrometry (HRMS). Moreover, a possible mechanism of aromatic nucleophilic substitution is proposed. [ABSTRACT FROM AUTHOR]- Published
- 2024
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28. A terpyridyl-imidazole based europium tris-(β-diketonate) complex as an efficient molecular luminescent thermometer and single component white light emitter via synergy in energy transfer between ligands and Eu3+.
- Author
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Ahmed, Toushique, Chakraborty, Amit, Maity, Sanchari, and Baitalik, Sujoy
- Subjects
LIGHT emitting diodes ,ENERGY transfer ,EUROPIUM ,TEMPERATURE sensors ,THERMOMETERS ,IMIDAZOLES - Abstract
The thermosensing and thermochromic behavior of one of our recently reported terpyridyl-imidazole based ternary europium tris-(β-diketonate) complexes of the composition [Eu(tta)
3 (tpy-HImzphen)] (tta = 2-thenoyltrifluoroacetone and tpy-HImzphen = 2-(4-[2,2′:6′,2′′] terpyridin-4′-yl-phenyl)-1H-phenanthro[9,10-d]imidazole) has been thoroughly investigated in this work. The said Eu(III) complex exhibits magnificent thermosensing as well as thermochromic properties and can be recommended as an excellent temperature sensor in a wide temperature domain of 273–343 K in terms of both emission intensity ratio (Sm = 5.78% K−1 at Tm = 343 K, δT = 0.012 K) and lifetime values (Sm = 3.36% K−1 at Tm = 333 K, δT = 0.009 K) or even in terms of its emitting color (red at 268 K, violet at 303 K, and blue at 343 K). Additionally, it displays remarkable solvent-induced luminescence behavior by displaying various emitting colors instead of its sole characteristic red emission upon varying the nature of the solvent. Finally, amalgamating these two features, we are able to attain white light emission (Commission Internationale de l'Eclairage coordinates: x = 0.34, y = 0.38) at 283 K from a single component. A plausible energy transfer mechanism has also been proposed in light of the existence of the ligand-to-metal charge transfer (LMCT) state as the quencher. [ABSTRACT FROM AUTHOR]- Published
- 2024
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29. Three water-soluble copper(II) N-heterocyclic carbene complexes: toward copper-catalyzed ketone reduction under sustainable conditions.
- Author
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Sharma, Mitu, Perkins, Amanda M., Awoyemi, Raymond Femi, Schmittou, Allison N., Raju, Selvam, Pierce, Brad S., Donnadieu, Bruno, Wipf, David O., Stokes, Sean L., and Emerson, Joseph P.
- Subjects
COPPER ,KETONES ,X-ray crystallography ,CYCLIC voltammetry ,BENZIMIDAZOLES ,IMIDAZOLES - Abstract
A series of tridentate copper(II) N-heterocyclic carbene (NHC) complexes with imidazole, benzimidazole, and 5,6-dimethylbenzimidazole azole rings were synthesized and comprehensively characterized via X-ray crystallography, ESI-MS, cyclic voltammetry, and UV-Vis and EPR spectroscopic studies. These complexes were then utilized for the optimization of ketone reduction under sustainable conditions using 2-acetylpyridine and phenylsilane. The relationships between product formation, temperature, reaction time, and catalyst loading for the hydrogenation reactions are covered in detail. Reduction of eighteen different aliphatic, cyclic, and aromatic ketones were demonstrated, which were compatible to produce the corresponding products in moderate to good yields. These systems were used to develop related DNA-hybrid catalytic systems, but only supported weak enantioselectivity. Further thermodynamic experiments showed Cu-NHC complexes did not demonstrate specific binding to DNA, which is consistent with their limited selectivity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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30. In vitro retardation and modulation of human insulin amyloid fibrillation by Fe3+ and Cu2+ ions.
- Author
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Paul, Swarnali, Begum, Shahnaz, Parvej, Hasan, Dalui, Ramkrishna, Sardar, Subrata, Mondal, Falguni, Sepay, Nayim, and Halder, Umesh Chandra
- Subjects
TRANSITION metal ions ,AMYLOID ,INSULIN ,CARRIER proteins ,AMYLOID beta-protein ,IONS ,IMIDAZOLES - Abstract
Metal ions of the later part of the first-row transition series (Fe, Co, Ni, Cu, and Zn) can form bonds through the carboxylate, hydroxyl, thiol, and imidazole side chains of proteins and those bonds are significantly more stable than those formed by non-transition metals. Their adventitious binding to protein surfaces provides a great platform for maintaining the native structure of many biologically significant proteins and thus inhibiting the self-aggregation phenomenon of proteins. Aggregation followed by deposition of proteins used for therapeutic purposes either at the site of administration in vivo or during storage conditions in vitro is a major concern. In this work, human insulin is induced to form 'amyloid fibrils' at acidic pH and elevated temperature and then the inhibitory activities of two transition metal ions Fe
3+ and Cu2+ towards insulin amyloid fibrillation were investigated. The results show that the formation of β-sheet-rich fibrillar structures was inhibited more with Fe3+ than Cu2+ -treated insulin. Dynamic light scattering and circular dichroism proved that Cu2+ was effective at lowering the interaction ratios with insulin, yet Fe3+ was effective in maintaining the size as well as the alpha-helical conformation of monomeric insulin. This metal complex (insulin-Fe3+ or insulin-Cu2+ ) delayed the nucleation step of aggregation and Fe3+ is far better than Cu2+ in this endeavor. However, both of the metal ions proved their effectiveness in preventing amyloid fibrillation in vitro and can modulate the morphology of the aggregates as revealed by TEM studies. Overall the two transition metal ions Fe3+ and Cu2+ employed in this investigation are essential micronutrients too and are required in minute concentrations. The present study will encourage the applications of transition metal ions Fe3+ and Cu2+ as effective interrupters of amyloidogenesis in aggregation-prone proteins showing pathogenic amyloid deposition. [ABSTRACT FROM AUTHOR]- Published
- 2024
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31. Insight into the conformational selectivity of cobalt(III) complexes with a tetradentate salen-type Schiff base ligand and their biorelevant catalysis: a combined experimental and theoretical study.
- Author
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Jana, Narayan Ch., Brandão, Paula, Gomila, Rosa M., Frontera, Antonio, and Panja, Anangamohan
- Subjects
SCHIFF bases ,CONFORMATIONAL isomers ,COBALT ,VOIDS (Crystallography) ,X-ray crystallography ,CATALYSIS ,DIAMINES ,IMIDAZOLES - Abstract
Salen-based octahedral trans metallo-salen complexes with monodentate co-ligands may exist as several conformational isomers, including stepped and umbrella shaped conformations. However, the factors governing the selective isolation of a particular conformer have not been investigated properly. In this report, six mononuclear cobalt(III) complexes (1–6) with a tetradentate salen-type Schiff base ligand, N,N′-bis(3-methoxy-5-methylsalicylidene)-ethane-1,2-diamine (H
2 L), and different heteroaromatic co-ligands (pyridines, imidazole and pyrazole) have been synthesized and characterized to unveil the influence of heteroaromatic co-ligands on the conformational (stepped versus umbrella) selectivity of the resulting complexes. X-ray crystallography reveals that the structures of 1–6 are eventually similar with only differences in the coordinated heteroaromatic moieties at axial positions and the accommodation of a different number of lattice solvent/guest molecules in the crystal voids. Interestingly, although a landscape of intermolecular non-covalent interactions are present in the solid state in these systems, the pyridyl co-ligands exclusively stabilize the umbrella-shaped conformation, while five-membered heteroaromatic bases prefer the stepped-shaped conformation, disclosing that the different degrees of intramolecular interactions (repulsion/attraction) of the six and five membered heteroaromatic ligands at the axial positions play the most important role in the selective stability of the different conformations in the solid state. All these complexes exhibit efficient catalytic activity mimicking the functions of phenoxazinone synthase and catechol oxidase. The catalyst recyclability test was also performed and it showed a very negligible change in catalytic efficiency even after five catalytic cycles. Theoretical calculations were performed to gain in-depth understanding of the preference of pyridine ligands for the umbrella-shaped conformation and the five-membered ring co-ligands for the stepped-shaped one, as well as for the mechanistic investigation of the aerobic oxidation of o-aminophenol in the presence of 1–6 as catalysts. [ABSTRACT FROM AUTHOR]- Published
- 2024
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32. A copper(II) metal–organic framework with 2,2-dimethylglutarate and imidazole ligands: synthesis, characterization and catalytic performance for cycloaddition of CO2 to epoxides.
- Author
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Köse Yaman, Pelin, Demir, Sevde, Denizaltı, Serpil, Erer, Hakan, and Yeşilel, Okan Zafer
- Subjects
METAL-organic frameworks ,COPPER ,EPOXY compounds ,X-ray powder diffraction ,LIGANDS (Chemistry) ,IMIDAZOLES - Abstract
A new three-dimensional (3D) framework with the general formula {[Cu(μ
3 -dmg)(im)2 ]·3H2 O}n (1) was synthesized using an aliphatic dicarboxylic acid linker 2,2-dimethylglutarate (dmg2− ) and nitrogen-containing imidazole ligand (im) under conventional methods. 1 was characterized by FT-IR spectroscopy, elemental analysis, single crystal and powder X-ray diffractions, and thermal analysis techniques. Additionally, the optical and topological properties of compound 1 were also investigated. The single crystal X-ray data exhibit that 1 is an interesting 3D framework and it has a I41 /a space group, which originates from two imidazole ligands, one dmg and three lattice water molecules. Topologically, 1 displays a lvt-a topology with the point symbol of {4.8.10}. In addition, the catalytic activity of compound 1 was investigated in the CO2 conversion into cyclic carbonates. It was found that compound 1 was an active catalyst even at low catalyst loading under 0.1 MPa CO2 at 80 °C. The yields of 23–99% were obtained. Compound 1 can be recycled at least four times without significant compromise in the activity in the first three catalytic reactions. [ABSTRACT FROM AUTHOR]- Published
- 2024
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33. Electrooxidation-induced synthesis of 3-thio/selenophosphorylated imidazole: a potent pesticide with good biocompatibility.
- Author
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Yin, Yonghong, Yang, Jianjing, Yan, Kelu, Zeng, Ting, Lin, Hongyan, Ling, Jing, Wang, Shibo, and Wen, Jiangwei
- Subjects
PESTICIDES ,BIOCOMPATIBILITY ,ORGANIC synthesis ,IMIDAZOLES ,ISOCYANATES ,ISOTHIOCYANATES ,INTERLEUKIN-6 - Abstract
The development of convenient and practical synthetic strategies for constructing bioactive molecules without metal residues is of great interest in organic synthesis. Herein, a metal-free, operationally simple, and scalable electrooxidation-induced three-component cross-coupling method to access 3-thio/selenophosphorylated imidazole derivatives from readily available isothiocyanates/isoselenocyanates, isocyanates, and H-phosphonates is first reported. More than 30 examples have been provided with good to moderate yields. Importantly, the readily accessible compounds could be used as pesticides (wheat anti-locust) with good biocompatibility (5d-stimulated RAW 264.7 macrophages, IL-6 = 5.3 pg mL
−1 , THF-α = 79.8 pg mL−1 ), reiterating the importance of the developed electrochemical methodology. [ABSTRACT FROM AUTHOR]- Published
- 2024
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34. Bimetallic nickel complexes containing imidazole-based phenolate ligands as efficient catalysts for the copolymerization of carbon dioxide with epoxides.
- Author
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Hsu, Han-Fang, Liu, Guan-Lin, Su, Yu-Chia, and Ko, Bao-Tsan
- Subjects
PHENOXIDES ,CARBON dioxide ,EPOXY compounds ,BIMETALLIC catalysts ,NICKEL catalysts ,COPOLYMERIZATION ,IMIDAZOLES - Abstract
The utilization of hexadentate imidazole-derived diamine-bisphenolate ligands to construct structurally well-defined bimetallic nickel catalysts that enable the mediation of the copolymerization of carbon dioxide with alicyclic epoxides was reported for the first time. A series of dinickel carboxylate/nitrophenolate complexes were facilely prepared through a one-pot procedure and their structures were fully determined by single crystal X-ray structural analysis. Dinickel complexes 1–10 were used as single-component catalysts, and were evaluated for the copolymerization of CO
2 and cyclohexene oxide (CHO), for which acetato-incorporated complex 1 was proved to exhibit the best activity. Not only has the controllability of binickel catalyst 1 for CO2 /CHO copolymerization been demonstrated, but also an "immortal" character for the same polymerization has been realized. Furthermore, detailed kinetic studies of polymerization catalysis of this type were undertaken, and the kinetics results revealed a first-order dependence on both Ni complex 1 and CHO concentrations. This is a successful example of the introduction of the easily accessible nitrogen-heterocycle group, the imidazole moiety, into phenolate ligands for the development of high-performance homogeneous catalysts towards the bimetallic complex-catalyzed copolymerization of CO2 and epoxides. [ABSTRACT FROM AUTHOR]- Published
- 2024
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35. Eco-friendly, in-water, and catalyst-free assembly of acylethenylpyrroloimidazoindoles from 3H-indoles and acylpyrrolylacetylenes.
- Author
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Oparina, Ludmila A., Belyaeva, Kseniya V., Kolyvanov, Nikita A., Ushakov, Igor A., Tomilin, Denis N., Sobenina, Lyubov N., Kuzmin, Anton V., and Trofimov, Boris A.
- Subjects
PYRROLES ,INDOLE compounds ,DIMETHYL sulfoxide ,RING formation (Chemistry) ,MOLECULES ,IMIDAZOLES - Abstract
The merging of fundamentally and biologically important heterocyclic structures, such as pyrroles, indoles, and imidazoles, in molecules of dihydropyrrolo[1′,2′:3,4]imidazo[1,2-a]indoles functionalized by E-acylethenyl groups was achieved in water on the platform of commercial 3H-indoles using readily available acylpyrrolylacetylenes as additional building blocks. The yields of the ensembles reached 88% (100 °C, 8 h), which is noticeably better than that produced using conventional solvents (MeCN, MeNO
2 , DMSO, and CF3 CH2 OH), wherein the reaction proceeds at a rate of approximately 10 times longer (96 h) with lower yields of the target products (not higher than 80%). The reaction presumably proceeds in a micellar-like microreactor self-assembled in a two-phase aqueous medium that secures favorable mutual orientation of the merging molecules, providing a facile [2+3] concerted cycloaddition to finally form fused polyheterocyclic systems. The performed DFT calculations are in agreement with such mechanistic considerations, particularly those underlying the crucial role of water in the studied cascade process. [ABSTRACT FROM AUTHOR]- Published
- 2024
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- View/download PDF
36. Nonlinear optical-active ferrocene conjugated Y-shaped imidazole donor–π–acceptor [(D–π)2–IM–π–A] compounds for dye-sensitized solar cells using non-corrosive copper complexes as a redox mediator
- Author
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Prabu, Selvam, Francesco, Fagnani, Colombo, Alessia, Dragonetti, Claudia, Biagini, Paolo, Melchiorre, Fabio, and Palanisami, Nallasamy
- Subjects
DYE-sensitized solar cells ,COPPER compounds ,FRONTIER orbitals ,NONLINEAR optical spectroscopy ,SECOND harmonic generation ,IMIDAZOLES ,TRIPHENYLAMINE ,FERROCENE - Abstract
Two new bis-ferrocene (Fc) conjugated Y-shaped imidazole (IM) based donor–π–acceptor [(D–π)
2 –IM–π–A] type "push–pull" compounds [(Fc–CH=CH)2 –IM–C8 H17 –C6 H4 –R] {R = COOC2 H5 (1); COOH (2)} have been synthesized for second-order nonlinear optics (1, ester) and dye-sensitized solar cell (2, acid) applications. The redox potentials of the compounds were examined using cyclic voltammetry, which shows one-electron charge transfer from the ferrocene to ferrocenium ion (Fe2+ Fe3+ ), and these potentials were employed to calculate the related energy gap. The second-order nonlinear optical (NLO) properties of the ester compound 1 were explored using the Electric-Field-Induced Second Harmonic generation (EFISH) technique in CHCl3 solution with an incident wavelength of 1907 nm, and it shows an interesting μβEFISH value of −780 × 10−48 esu. Besides, the carboxylic acid compound 2, adequately functionalized for anchoring to TiO2 , was tested as a photosensitizer in dye-sensitized solar cells (DSSCs) with non-corrosive Cu(I)/Cu(II) complexes as the redox mediator. Although the photovoltaic performance of 2 attached to TiO2 in a DSSC device is rather limited (JSC = 1.51 mA cm−2 , VOC = 404 mV, FF = 42.7, η = 0.26%), it confirms the potential of ferrocenyl conjugated D–π–A systems as photosensitizers. In addition, frontier molecular orbital levels, ground and excited state dipole moments (μg and μe ), and the origin of electronic absorption spectra were studied by using density functional theory (DFT) with the B3LYP method using 6-31+G** as the basis set. [ABSTRACT FROM AUTHOR]- Published
- 2024
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37. Computer-aided drug design applied to a series of pyridinyl imidazole derivatives targeting p38α MAP kinase: 2D-QSAR, docking, MD simulation, and ADMET investigations.
- Author
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El Aissouq, Abdellah, Lachhab, Aissam, El Rhabori, Said, Bouachrine, Mohammed, Ouammou, Abdelkrim, and Khalil, Fouad
- Subjects
COMPUTER-assisted drug design ,MITOGEN-activated protein kinases ,LIGAND binding (Biochemistry) ,IMIDAZOLES ,MOLECULAR dynamics ,MOLECULAR docking ,CHEMICAL structure - Abstract
The p38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammation. Here, 2D-QSAR and molecular docking studies were performed on a new series of pyridinyl imidazole derivatives as p38α MAPK inhibitors. The goal is to find a correlation between the chemical structures and inhibitory activity of the p38α MAPK. The partial least squares (PLS) regression method was used to build the 2D-QSAR model. The results revealed that the generated model yielded 0.85 for the determination coefficient (r
2 ), 0.83 for the adjusted determination coefficient (ra 2 ), and 0.16 for the root-mean-square error (RMSE). Internal and external validations were used to figure out how well the model could predict the future. The rcv 2 and rtest 2 values were 0.78 and 0.92, indicating that the developed model is robust and capable of predicting the activity of new compounds. The affinity of the ligands (pyridinyl imidazole derivatives) and the binding pocket of the p38α MAP kinase receptor was also determined by molecular docking using autoDock tools. The results revealed the importance of conventional hydrogen bonds in the binding pocket of the p38α MAPK receptor. Based on these results, a novel series of compounds were predicted and evaluated using molecular dynamics (MD) and ADMET prediction investigations. The study's findings might pave the way for the development of new pyridinyl imidazole derivatives that are able to inhibit the enzymatic activity of the p38α MAP kinase. [ABSTRACT FROM AUTHOR]- Published
- 2022
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38. Imidazole-based AIEgens for highly sensitive and selective detection of picric acid.
- Author
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Zhang, Yuzhu, Tang, Fang, He, Xuan, Wang, Chengyuan, Kong, Lin, Yang, Jiaxiang, and Ding, Aixiang
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PICRIC acid ,IMIDAZOLES ,PHOTOINDUCED electron transfer ,INTELLIGENT sensors ,MOLECULAR conformation ,DETECTION limit - Abstract
Imidazole is an important heterocyclic motif and its derivatives are widely used in many fields such as catalysis, medicine, and smart sensors. Here we report the synthesis of four imidazole derivatives (M1, M2, M3, and M4) with different fused aromatics as fluorescent sensors for picric acid (PA) detection. The four compounds with modifications of triphenylamine or tetraphenylethylene at the N
1 and C2 positions of the imidazole ring exhibit typical aggregation-induced emission (AIE) properties. The single crystallography results indicate that the bright luminescence is ascribed to the rigidified molecular conformation by multiple weak interactions. As PA probes, M1–M4 show high selectivity and sensitivity in the tetrahydrofuran/water mixture (fw = 99%). The detection limits are as low as 10−9 M. Mechanism study suggests that photoinduced electron transfer (PET) is responsible for PA detection. These AIE-active imidazole derivatives have been demonstrated to be convenient and easily operating sensors for PA detection. [ABSTRACT FROM AUTHOR]- Published
- 2022
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39. Controlled synthesis of a PS/Au/ZIF-8 hybrid structure as a SERS substrate for ultrasensitive detection.
- Author
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Xue, Xiangxin, Chen, Lei, Wang, Chunxu, Qiao, Yu, Zhao, Cuimei, Wang, Hairui, Nie, Ping, Li, Jiahui, Zhao, JinFu, and Chang, Limin
- Subjects
IMIDAZOLES ,METAL-organic frameworks ,MATERIALS analysis ,DETECTION limit - Abstract
In this paper, PS (polystyrene)/Au/ZIF-8 (zeolite imidazole framework-8) hybrid structures were synthesized for the first time as novel SERS active substrates. A series of substrates were successfully prepared by changing the Au sputtering time (5 min, 8 min, 10 min, 15 min and 20 min). When the sputtering time of Au was 10 min, the 4-mercaptobenzoic acid (4-MBA) molecules on the PS/Au/ZIF-8 substrate exhibited the maximum SERS enhancement. Meanwhile, the hybrid SERS substrate exhibited good SERS reproducibility, and we successfully obtained an ultrahigh enhancement factor of 1.67 × 10
6 . Probe molecules can be easily enriched on the surface of the PS/Au/ZIF-8 composite due to their large pore volume and the high surface area of metal organic framework (MOF) materials. ZIF-8 also guides the probe molecules to the "hot-spots" to enhance the SERS signals. Moreover, the detection limit of R6G molecules achieved was 10−12 M when PS/Au(10 min)/ZIF-8 was used as a highly sensitive SERS sensor. This strategy has brought new insights to SERS research, and has also provided a new idea for the application and development of SERS in MOF-based SERS materials and ultra-sensitive analyses. [ABSTRACT FROM AUTHOR]- Published
- 2021
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40. Salts of barbituric and 2-thiobarbituric acids with imidazole: polymorphism, supramolecular structure, thermal stability and water solubility.
- Author
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Lakeev, Alexander P., Sukhikh, Taisiya S., Kurzina, Irina A., Korotchenko, Natalia M., and Nikitin, Dmitriy S.
- Subjects
GEOTHERMAL resources ,THERMAL stability ,X-ray powder diffraction ,SOLUBILITY ,IMIDAZOLES ,PHTHALIC acid ,INTERMOLECULAR interactions - Abstract
Barbituric acids are a useful tool for the construction of various supramolecular compounds with intriguing physicochemical properties. Also, barbiturates play a significant role in biology and medicine. The same is true for imidazole derivatives. Herein, three novel salts of barbituric (H
2 BA) and 2-thiobarbituric (H2 TBA) acids with imidazole (Im), namely imidazolium barbiturate in two polymorphic modifications, HIm(HBA) (1) (pale yellow) and (2) (pale orange), and imidazolium 2-thiobarbiturate, HIm(HTBA) (3), were synthesized and characterized by CHNS elemental analysis, single-crystal and powder X-ray diffraction, FT-IR and UV-Vis spectroscopy techniques. Crystal structure analysis revealed that the compounds feature three different supramolecular architectures with the formula unit count (Z′) varying from 1 for 3 to 4 for 1, which is governed by an unusual geometry of hydrogen bonding motifs. Intermolecular interactions in crystals 1–3 were analyzed using 2D-fingerprint plots derived from the Hirshfeld surfaces. According to the TG-DSC analysis, compounds 1–3 were thermally stable up to ∼100 °C in air. The solubility studies (solubility product constants and solubility at a fixed pH value were determined) showed that salts 2 and 3 were more soluble in water than H2 (T)BA. To the best of our knowledge, this is one of the first reports on the phenomenon of polymorphism among organic salts with barbiturate moieties. Thus, the present findings broaden our understanding of the supramolecular organization of barbiturates, complement the systematic studies of the correlation between their crystal structure and physicochemical properties and lay the foundation for the further development of novel materials based on imidazolium (2-thio)barbiturates. [ABSTRACT FROM AUTHOR]- Published
- 2023
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41. Exploiting click-chemistry: backbone post-functionalisation of homoleptic gold(I) 1,2,3-triazole-5-ylidene complexes.
- Author
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Richter, Leon F., Marques, Fernanda, Correia, João D. G., Pöthig, Alexander, and Kühn, Fritz E.
- Subjects
SPINE ,GOLD ,CANCER cells ,TRIAZOLES ,METALS ,RING formation (Chemistry) ,IMIDAZOLES - Abstract
The synthesis of a homoleptic azide-functionalised Au(I) bis-1,2,3-triazole-5-ylidene complex is reported, starting from a backbone-modified 1,2,3-triazolium salt ligand precursor. The incorporated azide handle allows for a straightforward modification of the complex according to click-chemistry protocols without impacting the steric shielding around the metal center, demonstrating the superiority of the presented triazole ligand framework over imidazole based systems. Employing the SPAAC and the CuAAC reactions, post-modification of the complex is facilitated with two model substrates, while retaining very high antiproliferative activity (nanomolar range IC
50 values) in A2780 and MCF-7 human cancer cells. [ABSTRACT FROM AUTHOR]- Published
- 2023
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42. 2-Pyridine cyclic triimidazole as a chelating and bridging ligand in mono- and hexa-nuclear Re(I) complexes with emissive properties in solution and in the solid state.
- Author
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Malpicci, Daniele, Maver, Daniele, Maggioni, Daniela, Mercandelli, Pierluigi, Carlucci, Lucia, Cariati, Elena, Mussini, Patrizia, and Panigati, Monica
- Subjects
TIME-dependent density functional theory ,SOLID solutions ,BRIDGING ligands ,CHELATES ,DENSITY functional theory ,IMIDAZOLES ,FURAZANS - Abstract
Two luminescent Re(I) complexes, namely mononuclear fac-[ReCl(CO)
3 (TT-Py)] (1) and hexanuclear [{Re(μ-Cl)(CO)3 (μ-TT-Py)}{Re2 (μ-Cl)2 (CO)6 }]2 (2), were isolated in high yields by a one-pot reaction between [ReCl(CO)5 ] and different amounts of nitrogen-rich 2-pyridine cyclic triimidazole (TT-Py), which acts as a chelating ligand in both derivatives. The metallo-supramolecular cyclic structure of 2, which can be described as a metallacycle in which two mononuclear units of 1 act as bridging ligands towards two "Re2 (μ-Cl)2 (CO)6 " fragments, was confirmed by single-crystal X-ray diffraction analysis. Both complexes were fully characterized in solution by 1D and 2D multinuclear NMR spectroscopy. 1 and 2 exhibit photoluminescence at room temperature in solution, with a broad unstructured emission in the 530–570 nm range. The nature of the excited states involved in the electronic absorption spectrum of 1 was ascertained by a combined density functional theory and time-dependent density functional theory (TD-DFT) study. Both compounds exhibit strong aggregation induced emission enhancement (AIEE), which is more pronounced for 2 leading to a solid state photoluminescence quantum yield of 2.5% that is one of the highest values ever reported for Re(I) polynuclear metallacycles so far. The versatility of TT-Py to adopt variegated coordination modes, previously observed for Cu(I) and Cu(II) derivatives, is confirmed supporting further use of this ligand to obtain new and peculiar emissive mono-, polynuclear and extended coordination systems. [ABSTRACT FROM AUTHOR]- Published
- 2023
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43. Protonated and deprotonated vanadyl imidazole tartrates for the mimics of the vanadium coordination in the FeV-cofactor of V-nitrogenase.
- Author
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Shuang-Shuang Zhu, Zhen-Lang Xie, Lan Deng, Si-Yuan Wang, Lu-Bin Ni, and Zhao-Hui Zhou
- Subjects
TARTRATES ,VIBRATIONAL circular dichroism ,VANADIUM ,IMIDAZOLES ,EINSTEIN-Podolsky-Rosen experiment ,COFACTORS (Biochemistry) - Abstract
Chiral imidazole-based oxidovanadium tartrates (H
2 im)2 [Δ,Λ-VIV 2 O2 (R,R-H2 tart)(R,R-tart)(Him)2 ]·Him (1, H4 tart = tartaric acid, Him = imidazole) and [Λ,Λ-VIV 2 O2 (R,R-tart)(Him)6 ]·4H2 O (2) and their corresponding enantiomers (H2 im)2 [Λ,Δ-VIV 2 O2 (S,S-H2 tart)(S,S-tart)(Him)2 ]·Him (3) and [Δ,Δ-VIV 2 O2 (S,S-tart)(Him)6 ]·4H2 O (4) were obtained in alkaline solutions. Interestingly, the tartrates chelate with vanadium bidentately through α-alkoxy/α-hydroxy and α-carboxy groups and imidazole coordinates monodentately through nitrogen atom. It is worth noting that complexes 1 and 3 contain both protonated α-hydroxy and deprotonated α-alkoxy groups simultaneously, which have short V–Oα-alkoxy distances [1.976(4)av Å in 1–4] and long V–Oα-hydroxy distances [2.237(3)av Å in 1 and 2.230(2)av Å in 3]. There is an interesting strong intramolecular hydrogen bond [O(11)⋯O(1) 2.731(5) Å] between the two parts in 1 and 3. The protonated V–O distances are closer to the average bond distance in reported FeV-cofactors (FeV-cos, V–Oα-alkoxy 2.156av Å) in VFe proteins, which corresponds to the feasible protonation of coordinated α-hydroxy in R-homocitrate in V-nitrogenase, showing the homocitrate in the mechanistic model for nitrogen reduction as a secondary proton donor. Furthermore, vibrational circular dichroism (VCD) and IR spectra of 1–4 pointed out the disparity between the characteristic vibrations of the C–O and C–OH groups clearly. EPR experiment and theoretical calculations support +4 oxidation states for vanadium in 1–4. Solution13 C {¹H} NMR spectra and CV analyses exhibited the solution properties for 1 and 2, respectively, which indicates that there should be a rapid exchange equilibrium between the protonated and deprotonated species in solutions. [ABSTRACT FROM AUTHOR]- Published
- 2023
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44. Impact of exposed crystal facets on oxygen reduction reaction activity in zeolitic imidazole frameworks.
- Author
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Pimu, Sorawich, Yodsin, Nuttapon, Maneewan, Sirawee, Kanthachan, Jaruwan, Namuangruk, Supawadee, and Kongpatpanich, Kanokwan
- Subjects
OXYGEN reduction ,CRYSTALS ,CRYSTAL morphology ,METAL-organic frameworks ,IMIDAZOLES - Abstract
ZIF-67 is a representative type of metal–organic framework (MOF) developed for the oxygen reduction reaction (ORR) owing to its robust structure in alkaline electrolytes and the presence of the redox-active Co
2+ species in the structure. In this work, the improvement of the ORR electrolytic performance of ZIF-67 in its pure phase by optimization of its crystal morphology and crystal facets has been presented. ZIF-67 nanocubes exhibit higher ORR activity than their bulk crystals. The enriched (100) facet in the nanocube crystals provides a higher number of exposed Co2+ sites resulting in improved ORR performances. Moreover, DFT study suggests a distinguished mechanism in the (100) facet highlighting the importance of crystal facets in electrochemical performances. [ABSTRACT FROM AUTHOR]- Published
- 2023
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- View/download PDF
45. Synthesis, characterization, luminescence properties and deciphering the role of a terpyridyl-imidazole based ligand in the dissimilar luminescence sensitization of ternary lanthanide(III) tris-(β-diketonate) complexes.
- Author
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Ahmed, Toushique, Chakraborty, Amit, Paul, Animesh, and Baitalik, Sujoy
- Subjects
RARE earth metals ,LUMINESCENCE ,EMISSION spectroscopy ,EXCITED states ,SINGLE crystals ,IMIDAZOLES ,METAL ions ,TERBIUM - Abstract
We designed four ternary lanthanide tris-(β-diketonate) complexes of the form [Ln(tta)
3 (tpy-HImzphen)], where Ln = LaIII , EuIII , SmIII and TbIII ; tta = (2-theonyltrifluoroacetonate) and tpy-HImzphen = 2-(4-[2,2′:6′,2′′]terpyridin-4′-yl-phenyl)-1H-phenanthro[9,10-d]imidazole. All the complexes have been thoroughly characterized by standard analytical tools and spectroscopic techniques including single crystal X-ray diffraction. In situ generation of the complexes was also monitored via absorption and emission spectroscopy upon incremental addition of the respective lanthanide precursor {Ln(tta)3 (H2 O)2 } to the dichloromethane solution of the terpyridyl-imidazole ligand. The photophysical behaviors of all the complexes were thoroughly investigated via absorption and both steady-state and time-resolved emission spectroscopic techniques. The emission spectral measurements were carried out at both room temperature and 77 K to understand the deactivation dynamics of the excited states and elucidate the distinctive luminescence responses from the four lanthanide metal ions owing to the introduction of the terpyridyl-based ancillary ligand. [ABSTRACT FROM AUTHOR]- Published
- 2023
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46. Synthesis of metal–organic framework microrings via an anisotropic growth-etching approach.
- Author
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Zhang, Yue, Deng, Rong, Yuan, Ling, Zhang, Chaoqi, Wang, Jing, and Liu, Chao
- Subjects
METAL-organic frameworks ,CARBON-based materials ,OXYGEN reduction ,NANOSTRUCTURED materials ,PYROLYSIS ,IMIDAZOLES - Abstract
Design of metal–organic frameworks (MOFs) with elaborate structural features is of great significance for their applications with improved performances. In this work, we report the construction of unique zinc-based zeolite imidazole framework (ZIF-8) microrings via an anisotropic growth-etching route. The synthesis relies on the anisotropic deposition of ZIF-8 crystals on the edges with coordinatively unsaturated Zn
2+ of leaf-like ZIF (ZIF-L) nanosheets and subsequent selective etching of alkaline unstable ZIF-L. Furthermore, functional carbon materials with a ring-like structure can be prepared by pyrolysis of ZIF-8 microrings as precursors, exhibiting enhanced oxygen reduction reaction performance compared to the traditional ZIF-8 derived counterparts. Our work may pave the way for the design of MOFs with sophisticated micro/nanostructures. [ABSTRACT FROM AUTHOR]- Published
- 2023
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47. Enhancing electrochemical properties of a two-dimensional zeolitic imidazole framework by incorporating a conductive polymer for dopamine detection.
- Author
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Liu, Jing, Yin, Bing, Liu, Xiaobo, Yang, Cheng, Zang, Shiyu, and Wu, Shuo
- Subjects
DOPAMINE ,OPTOELECTRONIC devices ,CHARGE exchange ,SURFACE morphology ,ELECTRIC conductivity ,GAS storage ,IMIDAZOLES ,CONDUCTING polymers - Abstract
The zeolitic imidazole framework with a leaf-shaped morphology (ZIF-L) has a wide range of promising applications in gas storage, battery materials, catalytic reactions, and optoelectronic devices due to its planar leaf-like structure and large surface area. However, the low conductivity, weak catalytic activity, and poor stability in the water dielectric medium of ZIF-L limit its further practical application. To solve these problems, we added the conductive polymer heterocyclic poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) to ZIF-L for the sensitive detection of dopamine (DA). The synthesized composite ZIF-L/PEDOT:PSS (ZIF-L/PEDOT) not only retained the surface morphology of ZIF-L but also exhibited excellent electrochemical properties. The higher electrical conductivity of ZIF-L/PEDOT than that of ZIF-L was due to the enhanced electron transfer at the interface between ZIF-L and PEDOT:PSS. As a result, we developed an electrochemical biosensor based on the ZIF-L/PEDOT composite, which has a limit of detection of 7 nM for DA and a wide linear range from 25 nM to 500 μM. Furthermore, the current drop was negligible after 28 days, proving that the biosensor has excellent stability. Based on the above-mentioned outstanding performance, the ZIF-L/PEDOT-based biosensor was successfully used to detect DA in human serum samples. These results demonstrated that ZIF-L/PEDOT is expected to play an essential role in disease detection. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
48. Integrated battery–capacitor storage system: polyaniline interwoven Co-ZIF-derived hollow NiCo-LDH with enhanced electrochemical properties for hybrid supercapacitors.
- Author
-
Guo, Hao, Tian, Jiaying, Wang, Mingyue, Chen, Yuan, Wu, Ning, Peng, Liping, Liu, Yinsheng, Xu, Xijia, and Yang, Wu
- Subjects
POLYANILINES ,LAYERED double hydroxides ,SUPERCAPACITORS ,ENERGY density ,SUPERCAPACITOR electrodes ,POWER density ,IMIDAZOLES - Abstract
Layered double hydroxides (LDHs) are battery-type supercapacitor electrode materials with application potential due to their abundant active metal sites and surface functional groups. The traditional LDH structure easily aggregates and collapses. In this work, a stable cobalt zeolite imidazole framework (Co-ZIF) was used as the derived template to grow LDH nanosheets in situ to increase the contact area with the electrolyte, and polyaniline (PANI) acted as a conductive bridge to provide a rapid charge transfer pathway. The fabricated NiCo-LDH@PANI hollow structure demonstrated a specific capacity of 1315 C g
−1 at 1 A g−1 and achieved a rate capacity of 951 C g−1 at 20 A g−1 . Furthermore, the battery–supercapacitor hybrid device (NiCo-LDH@PANI//AC) exhibited an high energy density of 66.2 W h kg−1 at a power density of 800 W kg−1 with 95.5% capacitance retention after 20 000 cycles. [ABSTRACT FROM AUTHOR]- Published
- 2023
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- View/download PDF
49. 3D C–Co–N-anchored MWCNTs derived from metal–organic frameworks as high-performance electrochemical sensing platforms for the sensitive detection of adrenaline.
- Author
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Huang, Wei, Liu, Fengping, Xiang, Gang, Zhang, Zhenfa, Huang, Qing, Pan, Zhenjie, Zhuge, Wenfeng, and Peng, Jinyun
- Subjects
METAL-organic frameworks ,MULTIWALLED carbon nanotubes ,ADRENALINE ,ELECTROCHEMICAL sensors ,DETECTION limit ,IMIDAZOLES - Abstract
Metal–organic frameworks (MOFs) are composed of metal ions and organic ligands with high specific surface areas, controllable porous structures and abundant metal active sites, showing their extraordinary potential in electrochemical sensors. Here, a 3D conductive network structure (C–Co–N@MWCNTs) is designed by anchoring zeolite imidazole frameworks (ZIF-67) onto multi-walled carbon nanotubes (MWCNTs) and carbonizing them. The C–Co–N@MWCNTs exhibit excellent electron conductivity, a porous structure and considerable electrochemical active sites, which can effectively demonstrate high sensitivity and selectivity in the detection of adrenaline (Ad). The Ad sensor exhibited a low detection limit of 6.7 nmol L
−1 (S/N = 3) and a wide linear range of 0.02 μmol L−1 –1.0 mmol L−1 . The developed sensor also displayed high selectivity, good reproducibility and repeatability. The C–Co–N@MWCNTs electrode was further employed in the detection of Ad in a real sample of human serum, suggesting that it is a promising candidate for electrochemical sensing of Ad. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
50. An oxalamide-bridged imidazole based 'turn off' fluorescent receptor for copper(II) and iron(III) ions.
- Author
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Murugaperumal, Parvathavarthini, Rajendran, Praveena, Nallathambi, Sengottuvelan, Ayyanar, Siva, Perdih, Franc, Balasubramaniem, Ashokkumar, and Alagarsamy, Arun
- Subjects
CHEMORECEPTORS ,COPPER ,IRON ,ESCHERICHIA coli ,IONS ,IMIDAZOLES ,DENSITY functional theory - Abstract
We describe the synthesis of a symmetrical N,N′-bis(3-(1H-imidazol-1-yl)propyl)oxalamide-based receptor OX(PID)
2 and its characterization by different physicochemical techniques, namely FT-IR,1 H and13 C NMR, TGA, and mass spectrometry. Single crystal X-ray diffraction analysis shows that OX(PID)2 crystallizes in monoclinic space group P21/c. The sensing capability of OX(PID)2 towards various cations has been exhaustively investigated using UV-vis and fluorescence spectroscopy. OX(PID)2 shows high selectivity and sensitivity towards Cu2+ and Fe3+ ions with a 1 : 1 binding ratio over other metal ions, which was highly supported via Job's plot and density functional theory calculations. The Cu2+ and Fe3+ ions induce the 'turn-off' signal when interacting with OX(PID)2 . Moreover, using four different bacterial species, including S. aureus, B. subtilis, E. coli, and K. pneumonia, the biological activities of the newly created oxalamide-based compounds were assessed against various pathogenic bacteria and compared to streptomycin as a reference drug. Our substances exhibit moderate to good vital action against the aforementioned harmful microorganisms, according to the results. Then, fluorescence imaging in MDA-MB-231 on receptor OX(PID)2 suggested that OX(PID)2 had great potential in the application of bioimaging. The receptor with Cu2+ or Fe3+ ions was found to be cytotoxic against MDA-MB-231 and could be used as an anticancer agent. [ABSTRACT FROM AUTHOR]- Published
- 2023
- Full Text
- View/download PDF
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