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The objective of this deliverable is to create a tool meaningful and useful for the researchers of the nine ENLIGHT universities to help them to become familiar with ENLIGHT and ENLIGHT RISE and to enable them to start research collaborations within the ENLIGHT alliance.

Dieser Artikel möchte für die wachsende Bedeutung von systematischen Übersichtsarbeiten in den Human- und Sozialwissenschaften und die diversen Möglichkeiten der Unterstützung solcher Studien von bibliothekarischer Seite sensibilisieren. Er schildert die Entwicklung systematischer Übersichtsarbeiten in den letzten 10 Jahren, analysiert, welche Rollen dabei Fachreferent*innen bzw. Information Specialists zufallen können und gibt Empfehlungen, welchen konkreten Beitrag die Berufsgruppe der wissenschaftlichen Bibliothekar*innen für solche Forschungsprojekte leisten kann. This article aims to raise awareness of the growing importance of systematic reviews in the human and social sciences and the various ways in which libraries can support such studies. It describes the development of Systematic Reviews over the last 10 years, analyzes which roles can be played by subject librarians and information specialists and gives recommendations on the concrete contribution that the professional group of academic librarians can make to such research projects.

This article aims to provide an overview of the form, structure and content of conference posters for researchers who intend to submit an academic poster to a conference. It focuses in particular on the design and layout of academic conference posters, making some suggestions for possible poster layouts. It also provides information about factors influencing conference selection. Finally, it summarises some top tips to be considered when creating a conference poster such as font selection and use of images.

Background: Health libraries have been established as publication support services. Despite its importance, there is currently no study about the services that these centers offer. The aim of this work is to understand the role that libraries play in institutional scientific publishing policies. Material and methods: The sample was taken from the National Catalogue of Hospitals, the list of libraries of the Catalogue of Periodicals in Spanish Health Sciences Libraries (c17) and the National Catalogue of Health Sciences Publications (CNCS). Subsequently, virtual health libraries have also been incorporated. From this list, a questionnaire about library staff and activities related to publication process was sent. Results: We obtained a participation rate of 61.21%. The average number of technical personnel was 1.15 in virtual libraries and 0.81 in hospital libraries. The activities carried out have been: training activities (82.2%), counselling (90.1%), dissemination (30.7%) and evaluation (50.5%) Conclusions: The staff in libraries are insufficient. In many cases technicians assume an overwork of serving in both (virtual and hospital libraries). Most libraries offer training and research support services although there are differences between virtual and hospital ones. There is a relationship between the number of technicians and the publication support services.

Materials and text from a keynote given at the Mississippi State University ScholComm Summit on July 22nd, 2016. My presentation was inspired and substantially influenced by "Strategies and partnerships: tailoring data services for your institutional needs" accessible at https://osf.io/pju7g/ "Data services" is a new and developing area of work that libraries are exploring. This talk briefly examines the genealogy of data services, from scholarly communication through public access funder mandates (#OSTPResp) to data visualization and curation, and opines about 5 guiding questions that libraries (and the academic library profession) must grapple with.

The operational guidelines describe the services of the Research and Innovation Support Group (R&I SG) that are available to ENLIGHT partners.

Globally, nearly half of all pregnancies are unplanned. Male contraceptives offer the potential to decrease unintended pregnancy and introduce contraceptive equity, but decades of research have yet to bring a novel product to market. New funding avenues from the philanthropic sector seek to stimulate research in male contraceptives through investments, grants, and support for trainees alongside other programs that encourage product development and ultimately commercialization. This Forum outlines the purpose of and funding opportunities provided by Male Contraceptive Initiative, a funding agency and non-profit focused on the advancement of non-hormonal, reversible contraceptive technologies for those who produce sperm., Male contraception offers unrealized potential for improving global health and well-being, and increased research support is available to the reproductive biology community that facilitates further study in this important realm., Graphical Abstract Graphical Abstract

"Im Fokus neuer serviceorientierter Leistungen der UB stehen seit M��rz 2018 alle Forscher, angefangen vom Bachelor-Bereich bis hin zum Post-Doc. sowie alle Mitarbeiter der Universit��t. Au��erdem laufen Ank��ndigungen ��ber die Webseite der Universit��t Hildesheim im Veranstaltungskalender: https://www.uni-hildesheim.de/veranstaltungen/veranstaltungskalender/. Eine sehr hohe Motivation und Einsatztbereitschaft sind essentiell f��r eine gute Entwicklung des Forschungsdatenmanagement innerhalb der Bibliothek und am Campus. Mit ���Awareness���-Ma��nahmen wie Schulungen und Workshops hat sich die FDM-Stelle der UB inzwischen gut positionieren k��nnen." Quelle: https://www.password-online.de/?mailpoet_router&endpoint=view_in_browser&action=view&data=WzQ1LCIwZDkxNzMwYTg5YmMiLDAsMCwzOCwxXQ

"Im Fokus neuer serviceorientierter Leistungen der UB stehen seit März 2018 alle Forscher, angefangen vom Bachelor-Bereich bis hin zum Post-Doc. sowie alle Mitarbeiter der Universität. Außerdem laufen Ankündigungen über die Webseite der Universität Hildesheim im Veranstaltungskalender: https://www.uni-hildesheim.de/veranstaltungen/veranstaltungskalender/. Eine sehr hohe Motivation und Einsatztbereitschaft sind essentiell für eine gute Entwicklung des Forschungsdatenmanagement innerhalb der Bibliothek und am Campus. Mit „Awareness“-Maßnahmen wie Schulungen und Workshops hat sich die FDM-Stelle der UB inzwischen gut positionieren können." Quelle: https://www.password-online.de/?mailpoet_router&endpoint=view_in_browser&action=view&data=WzQ1LCIwZDkxNzMwYTg5YmMiLDAsMCwzOCwxXQ

In recent years, numerous studies and experiences have been developed in the field of teacher education that promotes professional development. These include works that manage to create and maintain a network, a community of practice or other forms of collaborative work among teachers, whether from the same educational level or from different institutions and levels. Most of these are joint work experiences carried out around the practical component in initial teacher training in which a methodology is used that falls within the broad field of qualitative research. Although all these studies reveal a field of work in which the productive relationships among the university, the educational centers, and their community are evident, none have addressed the professional growth of teachers through bidirectional training exchange between public early childhood and primary education centers and the university. This is a new format or formula that has proven to be effective and that allows further progress to be made in the field of initial and continuing teacher training. Aware of the benefits derived from this, the University of Granada (Spain) launches an initiative in the 2020-2021 academic year with the implementation of the experimental program HERMES. The main purpose is to create networks and working groups between teachers from schools and universities to facilitate the implementation of joint training, innovation and/or research projects in the next academic years. The bidirectional training stays between the educational center and the university give the Program an innovative profile within our country. This paper focuses its attention on it.

Academic librarians face multiple barriers in conducting the research that is expected in their work, yet they still manage to successfully complete it. This study aimed to identify the factors that contribute to their success. Through an online survey sent via email to a random sample of academic librarians in the United States, we gathered and analyzed quantitative data about education and experience, demographics, success factor statements, and research productivity to determine which factors are related to increased research output. We found that three categories of factors—Individual Attributes, Peers and Community, and Institutional Structures and Supports—contribute positively to overall research output. We identified several elements that academic librarians may want to pursue to increase research productivity, with Peers and Community identified as a category for exploration. Overall, we found that academic librarians are highly motivated to conduct research, yet the factors leading to their success are complex and varied.

New attention to the power of data in research has brought new kinds of data questions to the university research library. This study seeks to understand the character of research data questions in order to help research libraries develop the structures, technologies, collections, and professional skills needed to meet the needs of the research communities. It employs two original metrics to analyze 42 cases: The Data Question Typology, which allows for the organization of data questions into categories based on researcher objectives, and the Modified READ Scale for Data Questions (MRSD), which is used to record the magnitude of difficulty presented by each case. It finds that data questions differ significantly across academic fields and that successful research assistance often requires partnerships between subject specialists librarians and technological or computational experts. It concludes with a recommendation on how research libraries can facilitate a collaborative process and workflow for handling a diversity of data questions from across the university.

The Data Stewardship project is a new initiative from the Delft University of Technology (TU Delft) in the Netherlands. Its aim is to create mature working practices and policies regarding research data management across all TU Delft faculties. The novelty of this project relies on having a dedicated person, the so-called ‘Data Steward’, embedded in each faculty to approach research data management from a more discipline-specific perspective. It is within this framework that a research data management survey was carried out at the faculties that had a Data Steward in place by July 2018. The goal was to get an overview of the general data management practices, and use its results as a benchmark for the project. The total response rate was 11 to 37% depending on the faculty. Overall, the results show similar trends in all faculties, and indicate lack of awareness regarding different data management topics such as automatic data backups, data ownership, relevance of data management plans, awareness of FAIR data principles and usage of research data repositories. The results also show great interest towards data management, as more than ~80% of the respondents in each faculty claimed to be interested in data management training and wished to see the summary of survey results. Thus, the survey helped identified the topics the Data Stewardship project is currently focusing on, by carrying out awareness campaigns and providing training at both university and faculty levels.

Bipolar disorder (BD) is a complex neurobiological disease. It is likely that both neurons and glial cells are affected in BD, yet how these cell types are changed at the structural and functional level is still largely unknown. In this review we provide an overview of postmortem studies analyzing structural cellular changes in BD, including the density, number and size of neurons and glia. We categorize the results per cell-type and validate outcome measures per brain region. Despite variations by brain region, outcome measure and methodology, several patterns could be identified. Total neuron, total glia, and cell subtypes astrocyte, microglia and oligodendrocyte presence appears unchanged in the BD brain. Interneuron density may be decreased across various cortical areas, yet findings of interneuron subpopulations show discrepancies. This structural review brings to light issues in validation and replication. Future research should therefore prioritize the validation of existing studies in order to increasingly refine the conceptual models of BD.

Objective: To examine implementation and patients' and providers' participation and satisfaction of a newly developed decision support tool (DST) for patients with metastatic colorectal cancer (mCRC) in palliative setting.Methods: Our DST consisted of a consultation sheet and web-based tailored information for mCRC treatment options. We conducted an implementation trajectory in 11 Dutch hospitals and evaluated implementation, participation and satisfaction rates.Results: Implementation rates fluctuated between 3 and 72 handed out (median:23) consultation sheets per hospital with patients' login rates between 36% and 83% (median:57%). The majority of patients (68%) had (intermediate)-high participation scores. The median time spent using the DST was 38 min (IQR:18-56) and was highest for questions concerning patients' perspective (5 min). Seventy-six% of patients were (very) satisfied. The provider DST rating was 7.8 (scale 1-10) and participation ranged between 25 and 100%. Remaining implementation thresholds included providers' treatment preferences, resistance against shared decision-making and (over)confidence in shared decision-making concepts already in use.Conclusion: We implemented a DST with sufficient patient and oncologist satisfaction and high patient participation, but participation differed considerably between hospitals suggesting unequal adoption of our tool.Practice implications: Requirements for structural implementation are to overcome remaining thresholds and increase awareness for additional decision support. (C) 2019 Elsevier B.V. All rights reserved.

Expectations for Canadian academic librarians’ research have evolved, but not all librarians have access to the support systems needed that aid and enable them to conduct and publish research. A survey was sent to librarians asking about the research supports available and most useful to them. “Research” was not defined and was left to the interpretation of the participant. The survey found that supports are sporadic, possibly leading to a two-tiered research climate between “haves” and “have-nots.” It is essential for academic librarians to initiate and engage in conversation about what library research is and how librarians’ research competency may be improved. This should lead in turn to conversations about the support systems needed, which ones the universities and the libraries should provide, and how having a comprehensive research-support model would help librarians engage more with research, increase their research output, and improve the quality of their research.

OBJECTIVES: To establish an evidence-based cut-off to differentiate between early and late recurrence and to compare clinicopathologic risk factors between the two groups. SUMMARY BACKGROUND DATA: A clear definition of "early recurrence" after pancreatic ductal adenocarcinoma resection is currently lacking. METHODS: Patients undergoing pancreatectomy for pancreatic ductal adenocarcinoma between 2000 and 2013 were included. Exclusion criteria were neoadjuvant therapy and incomplete follow-up. A minimum P-value approach was used to evaluate the optimal cut-off value of recurrence-free survival to divide the patients into early and late recurrence cohorts based on subsequent prognosis. Potential risk factors for early recurrence were assessed with logistic regression models. RESULTS: Of 957 included patients, 204 (21.3%) were recurrence-free at last follow-up. The optimal length of recurrence-free survival to distinguish between early (n = 388, 51.5%) and late recurrence (n = 365, 48.5%) was 12 months (P < 0.001). Patients with early recurrence had 1-, and 2-year post-recurrence survival rates of 20 and 6% compared with 45 and 22% for the late recurrence group (both P < 0.001). Preoperative risk factors for early recurrence included a Charlson age-comorbidity index ≥4 (OR 1.65), tumor size > 3.0 cm on computed tomography (OR 1.53) and CA 19-9 > 210 U/mL (OR 2.30). Postoperative risk factors consisted of poor tumor differentiation grade (OR 1.66), microscopic lymphovascular invasion (OR 1.70), a lymph node ratio > 0.2 (OR 2.49), and CA 19-9 > 37 U/mL (OR 3.38). Adjuvant chemotherapy (OR 0.28) and chemoradiotherapy (OR 0.29) were associated with a reduced likelihood of early recurrence. CONCLUSION: A recurrence-free interval of 12 months is the optimal threshold for differentiating between early and late recurrence, based on subsequent prognosis.

Objective: To learn how to configure a patient communication aid (PCA) to facilitate shared decision-making (SDM) about treatment for advanced cancer.Methods: The PCA consists of education about SDM, a question prompt list, and values clarification methods. Study 1. A first veersion was presented to 13 patients, 8 relatives and 14 bereaved relatives in interviews. Study 2. A second version was used by 18 patients in a pilot study. Patients and oncologists were interviewed, patients were surveyed, and consultations were audio-recorded.Results: Respondents reported that the aid facilitated patient control over information, raised choice awareness and promoted elaboration. Risks were identified, most importantly that the aid might upset patients. Also, some respondents reported that the PCA did not, or would not support decision making because they felt sufficiently competent, did not perceive a role for themselves, or did not perceive that the decision required elaboration.Conclusions: Opinions on the usefulness of the PCA varied. It was challenging to raise awareness about the presence of a choice, and to find a balance between comprehensive information and sensitivity.Practice implications: A future study should demonstrate whether the PCA can improve SDM, and whether this effect is stronger when oncologists receive training. (C) 2018 Elsevier B.V. All rights reserved.

Renal transplant recipients have an increased risk of non-melanoma skin cancer (NMSC) compared to in the general population. Here, we show polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of NMSC in general, non-transplant setting, can predict risk of, and time to post-transplant skin cancer. Genetic variants, reaching pre-defined p-value thresholds were chosen from published squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) non-transplant GWAS. Using these genome-wide association studies, BCC and SCC PRS were calculated for each sample across three European-ancestry renal-transplant cohorts (n=889) and tested as predictors of case:control status and time to NMSC post-transplant. BCC PRS calculated at p-value threshold 1x10 was the most significant predictor of case:control status of NMSC post-transplant (OR=1.65; adjusted P=0.0008; AUC(full model adjusted for clinical predictors and PRS)=0.81). SCC PRS at p-value threshold 1x10 was the most significant predictor of time to post-transplant NMSC (adjusted P=8.15x10 ; HR=1.42, concordance (full model)=0.74). PRS of non-transplant NMSC is predictive of case:control status and time to NMSC post-transplant. These results are relevant to how genomics can risk stratify patients to help develop personalised treatment regimens. This article is protected by copyright. All rights reserved.

Purpose To develop and evaluate a dual-layer detector capable of acquiring intrinsically registered real-time fluoroscopic and nuclear images in the interventional radiology suite. Materials and Methods The dual-layer detector consists of an x-ray flat panel detector placed in front of a γ camera with cone beam collimator focused at the x-ray focal spot. This design relies on the x-ray detector absorbing the majority of the x-rays while it is more transparent to the higher energy γ photons. A prototype was built and dynamic phantom images were acquired. In addition, spatial resolution and system sensitivity (evaluated as counts detected within the energy window per second per megabecquerel) were measured with the prototype. Monte Carlo simulations for an improved system with varying flat panel compositions were performed to assess potential spatial resolution and system sensitivity. Results Experiments with the dual-layer detector prototype showed that spatial resolution of the nuclear images was unaffected by the addition of the flat panel (full width at half maximum, 13.6 mm at 15 cm from the collimator surface). However, addition of the flat panel lowered system sensitivity by 45%-60% because of the nonoptimized transmission of the flat panel. Simulations showed that an attenuation of 27%-35% of the γ rays in the flat panel could be achieved by decreasing the crystal thickness and housing attenuation of the flat panel. Conclusion A dual-layer detector was capable of acquiring real-time intrinsically registered hybrid images, which could aid interventional procedures involving radionuclides. Published under a CC BY-NC-ND 4.0 license. Online supplemental material is available for this article.

Research libraries in U.S. have continued looking for new ways to use library spaces to support the needs of learning, teaching, and research, with rapidly changing information technologies and high expectations for dynamic learning environment. Students and faculty look for research libraries to enable their collaboration, innovation, and explorations. The enhanced library space often features contemporary architectural and aesthetical design, at convenient locations, with concept of facilitating formal and informal learning, easy access to collections, technologies, supporting services, and flexible furniture arrangements to support a variety of learning activities. Since early spring 2020, library personnel at Auburn University in the United States, as with library colleagues around the world, have witnessed the unprecedented challenges of COVID-19. Through this period, the Libraries also re-examined the organizational structures, staffing mobilities, and the use of library space to meet users’ expectations. In this paper, the author will share experiences in re-imagining learning space and providing technology-enhanced services to fulfill the mission of research libraries and their parent institutions.

This article aims to provide an overview of the structure, form and content of systematic reviews. It focuses in particular on the literature searching component, and covers systematic database searching techniques, searching for grey literature and the importance of librarian involvement in the search. It also covers systematic review reporting standards such as PRISMA-P and PRISMA, critical appraisal and tools and resources to support the review and ensure it is conducted efficiently and effectively. Finally, it summarizes the requirements when screening search results for inclusion in the review, and the statistical synthesis of included studies’ findings.

ARDC's Data Management Planning Interest Group hosted a meetup on persistent identifiers and data management planning infrastructure on 17 June 2021. These slides accompanied Siobhann McCafferty's talk on PIDs infrastructure, RAiD and the Instruments for Identifiers Australasia Interest Group (I4IOZ).

This article provides an overview of writing for publication in peer-reviewed journals. While the main focus is on writing a research article, it also provides guidance on factors influencing journal selection, including journal scope, intended audience for the findings, open access requirements, and journal citation metrics. Finally, it covers the standard content of a scientific journal article, providing general advice and guidance regarding the information researchers would typically include in their published papers.

The Research Data Aliance and ARDC's Data Management Planning Interest Group co-hosted a webinar on infrastructure and data management plans. Specific tools for managing DMPs, infrastructure that uses DMPs and research infrastructure that is provisioned by DMP infrastructure. Updates from the recent Research Data Alliance Virtual Plenary 17 will also be included. Confirmed speakers ARDC Facilitators Liz Stokes and Kathryn Unsworth Stefanie Kethers, Research Data Alliance Peter Neish, University of Melbourne Rowland Mosbergen, Walter and Elizabeth Hall Institute Maria Praetzellis (John Chodacki), University of California - DMP Tool Andrew Brazzatti, Queensland Cyber Infrastructure Fund - ReDBox Peter Sefton, University of Technology. A video of this presentation can be found on ARDC's YouTube channel:https://youtu.be/9l5D78J4ULo

Purpose Treatment options are limited for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Tumor cells can exploit the programmed death-1 checkpoint pathway to evade immune surveillance. In the current study, we evaluated the efficacy and safety of programmed death-1 blockade by nivolumab in patients with relapsed/refractory DLBCL. Methods In this phase II, open-label study, patients with relapsed/refractory DLBCL who were ineligible for autologous hematopoietic cell transplantation (auto-HCT) or who had experienced failure with auto-HCT received nivolumab 3 mg/kg every 2 weeks. We assessed the efficacy and safety of nivolumab as well as genetic alterations of 9p24.1. Results Among 121 treated patients, patients in the auto-HCT–failed cohort (n = 87) received a median of four nivolumab doses and a median of three doses were administered to those in the auto-HCT–ineligible cohort (n = 34). At a median follow-up of 9 months in the auto-HCT–failed cohort and 6 months in the auto-HCT–ineligible cohort, independently assessed objective response rates were 10% and 3%, and median durations of response were 11 and 8 months, respectively. Median progression-free survival and overall survival were 1.9 and 12.2 months in the auto-HCT–failed cohort and 1.4 and 5.8 months in the auto-HCT–ineligible cohort respectively. All three patients with complete remission—3% of the auto-HCT–failed cohort—had durable response (11 or more, 14 or more, and 17 months). Treatment-related grade 3 and 4 adverse events were reported in 24% of patients. The most common were neutropenia (4%), thrombocytopenia (3%), and increased lipase (3%). Of all evaluable samples for 9p24.1 analysis, 16% exhibited low-level copy gain and 3% had amplification. Conclusion Nivolumab monotherapy is associated with a favorable safety profile but a low overall response rate among patients with DLBCL who are ineligible for auto-HCT or who experienced failure with auto-HCT. Genetic alterations of 9p24.1 are infrequent in DLBCL.

Summary Biosynthesis of the nucleotide sugar precursor dTDP‐L‐rhamnose is critical for the viability and virulence of many human pathogenic bacteria, including Streptococcus pyogenes (Group A Streptococcus; GAS), Streptococcus mutans and Mycobacterium tuberculosis. Streptococcal pathogens require dTDP‐L‐rhamnose for the production of structurally similar rhamnose polysaccharides in their cell wall. Via heterologous expression in S. mutans, we confirmed that GAS RmlB and RmlC are critical for dTDP‐L‐rhamnose biosynthesis through their action as dTDP‐glucose‐4,6‐dehydratase and dTDP‐4‐keto‐6‐deoxyglucose‐3,5‐epimerase enzymes respectively. Complementation with GAS RmlB and RmlC containing specific point mutations corroborated the conservation of previous identified catalytic residues. Bio‐layer interferometry was used to identify and confirm inhibitory lead compounds that bind to GAS dTDP‐rhamnose biosynthesis enzymes RmlB, RmlC and GacA. One of the identified compounds, Ri03, inhibited growth of GAS, other rhamnose‐dependent streptococcal pathogens as well as M. tuberculosis with an IC50 of 120–410 µM. Importantly, we confirmed that Ri03 inhibited dTDP‐L‐rhamnose formation in a concentration‐dependent manner through a biochemical assay with recombinant rhamnose biosynthesis enzymes. We therefore conclude that inhibitors of dTDP‐L‐rhamnose biosynthesis, such as Ri03, affect streptococcal and mycobacterial viability and can serve as lead compounds for the development of a new class of antibiotics that targets dTDP‐rhamnose biosynthesis in pathogenic bacteria.

Purpose: Pathogenic variations in genes encoding aminoacyl-tRNA synthetases (ARSs) are increasingly associated with human disease. Clinical features of autosomal recessive ARS deficiencies appear very diverse and without apparent logic. We searched for common clinical patterns to improve disease recognition, insight into pathophysiology, and clinical care. Methods: Symptoms were analyzed in all patients with recessive ARS deficiencies reported in literature, supplemented with unreported patients evaluated in our hospital. Results: In literature, we identified 107 patients with AARS, DARS, GARS, HARS, IARS, KARS, LARS, MARS, RARS, SARS, VARS, YARS, and QARS deficiencies. Common symptoms (defined as present in ≥4/13 ARS deficiencies) included abnormalities of the central nervous system and/or senses (13/13), failure to thrive, gastrointestinal symptoms, dysmaturity, liver disease, and facial dysmorphisms. Deep phenotyping of 5 additional patients with unreported compound heterozygous pathogenic variations in IARS, LARS, KARS, and QARS extended the common phenotype with lung disease, hypoalbuminemia, anemia, and renal tubulopathy. Conclusion: We propose a common clinical phenotype for recessive ARS deficiencies, resulting from insufficient aminoacylation activity to meet translational demand in specific organs or periods of life. Assuming residual ARS activity, adequate protein/amino acid supply seems essential instead of the traditional replacement of protein by glucose in patients with metabolic diseases.

Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls‐only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men, using data from the PASSYON study. In this cross‐sectional study, the HPV prevalence among 16‐ to 24‐year‐old visitors to sexually transmitted infection clinics was assessed in 2009, 2011, 2013, and 2015. We compared the genital postvaccination HPV prevalence with the prevaccination prevalence (2009) using Poisson GEE models. In total, we included 4,996 women and 1,901 heterosexual men. The percentage of women who reported to be vaccinated increased from 2.3% in 2009 to 37% in 2015. Among all women, the HPV16/18 prevalence decreased from 23% prevaccination to 15% in 2015 (adjusted prevalence ratio [aPR] 0.62, p trend < 0.01). Among heterosexual men, the HPV16/18 prevalence decreased from 17% prevaccination to 11% in 2015 (aPR 0.52, p trend < 0.01). Of the heterosexual men with a steady partner, HPV16/18 prevalence was lower among those whose steady partner had been vaccine‐eligible in the national immunization program (aPR 0.13). Among unvaccinated women, the HPV16/18 prevalence in 2015 was not different from prevaccination. The decreasing HPV16/18 prevalence among heterosexual men and the reduced HPV16/18 prevalence among heterosexual men with a vaccine‐eligible steady partner strongly suggests herd protection from girls‐only vaccination. Absence of notable herd effects among unvaccinated women 6 years postvaccination may be due to the moderate vaccine uptake among girls in the Netherlands., What's new? Human papillomavirus (HPV) is a sexually transmitted virus that plays a causal role in the development of anogenital and oropharyngeal cancers in both men and women. The population‐level impact of HPV vaccination programs on the HPV prevalence has however mainly been studied in women. This study shows decreasing trends in the HPV16 and HPV18 prevalence among both women and heterosexual men after the introduction of a girls‐only HPV16/18 vaccination program in the Netherlands. The findings provide compelling evidence for herd protection in men. Because HPV16/18 are the most oncogenic types, HPV‐related cancers are expected to decline in both sexes after girls‐only HPV vaccination.

Contains fulltext : 203188.pdf (Publisher’s version ) (Open Access) BACKGROUND: Hodgkin lymphoma (HL) survivors have an increased risk of gastrointestinal (GI) cancer. This study aims to evaluate whether survival of patients who survived HL and developed GI cancer differs from survival of first primary GI cancer patients. METHODS: Overall and cause-specific survival of GI cancer patients in a HL survivor cohort (GI-HL, N = 104, including esophageal, gastric, small intestinal, and colorectal cancer) was compared with survival of a first primary GI cancer patient cohort (GI-1, N = 1025, generated by case matching based on tumor site, gender, age, and year of diagnosis). Cox proportional hazards regression was used for survival analyses. Multivariable analyses were adjusted for GI cancer stage, grade of differentiation, surgery, radiotherapy, and chemotherapy. RESULTS: GI-HL cancers were diagnosed at a median age of 54 years (interquartile range 45-60). No differences in tumor stage or frequency of surgery were found. GI-HL patients less often received radiotherapy (8% vs 23% in GI-1 patients, P < 0.001) and chemotherapy (28% vs 41%, P = 0.01) for their GI tumor. Compared with GI-1 patients, overall and disease-specific survival of GI-HL patients was worse (univariable hazard ratio (HR) 1.30, 95% confidence interval (CI) 1.03-1.65, P = 0.03; and HR 1.29, 95% CI 1.00-1.67, P = 0.049, respectively; multivariable HR 1.33, 95% CI 1.05-1.68, P = 0.02; and HR 1.33, 95% CI 1.03-1.72, P = 0.03, respectively). CONCLUSIONS: Long-term overall and disease-specific survival of GI cancer in HL survivors is worse compared with first primary GI cancer patients. Differences in tumor stage, grade of differentiation, or treatment could not explain this worse survival.

Background: One of the claimed main advantages of individual participant data meta-analysis (IPDMA) is that it allows assessment of subgroup effects based on individual-level participant characteristics, and eventually stratified medicine. In this study, we evaluated the conduct and results of subgroup analyses in IPDMA. Methods: We searched PubMed, EMBASE and the Cochrane Library from inception to 31 December 2014. We included papers if they described an IPDMA based on randomized clinical trials that investigated a therapeutic intervention on human subjects and in which the meta-analysis was preceded by a systematic literature search. We extracted data items related to subgroup analysis and subgroup differences (subgroup-treatment interaction p

Objective - This research studied the recent literature of two professions, library and information studies (LIS) and research administration (RA), to map the priorities and concerns of each with regard to research support. Specifically, the research sought to answer these research questions: (1) What are the similarities and differences emerging from the LIS and RA literatures on research support? (2) How do librarians and research administrators understand and engage with each other’s activities through their professional literatures? (3) Do Whitchurch’s (2008a, 2008b, 2015) concepts of bounded-cross-boundary-unbounded professionals and theory of the “third space” provide a useful framework for understanding research support? Methods - The research method was a content analysis of journal articles on research-related topics published in select journals in the LIS (n = 195) and RA (n = 95) fields from 2012-2017. The titles and abstracts of articles to be included were reviewed to guide the creation of thematic coding categories. The coded articles were then analyzed to characterize and compare the topics and concerns addressed by the literature of each profession. Results - Only two (2.2%) RA articles referred to librarians and libraries in their exploration of research support topics, while six (3.1%) LIS articles referred to the research office or research administrators in a meaningful way. Of these six, two focused on undergraduate research programs, two on research data management, and two on scholarly communications. Thematic coding revealed five broad topics that appeared repeatedly in both bodies of literature: research funding, research impact, research methodologies, research infrastructure, and use of research. However, within these broad categories, the focus varied widely between the professions. There were also several topics that received considerable attention in the literature of one field without a major presence in that of the other, including research collaboration in the RA literature, and institutional repositories, research data management, citation analysis or bibliometrics, scholarly communication, and open access in the LIS literature. Conclusion - This content analysis of the LIS and RA literature provided insight into the priorities and concerns of each profession with respect to research support. It found that, even in instances where the professions engaged on the same broad topics, they largely focused on different aspects of issues. The literature of each profession demonstrated little awareness of the activities and concerns of the other. In Whitchurch’s (2008a) taxonomy, librarians and research administrators are largely working as “bounded” professionals, with occasional forays into “cross-boundary” activities (p. 377). There is not yet evidence of “unbounded” professionalism or a move to a “third space” of research support activity involving these professions (Whitchurch, 2015, p. 85). Librarians and research administrators will benefit from a better understanding of the current research support landscape and new modes of working, like the third space, that could prove transformative. With funding from the Canadian Association of Research Libraries (CARL) Faculty yes

Background The Netherlands is one of the six European countries considered on track to eliminate hepatitis C virus by 2030. To achieve this goal, continuous efforts have to be put into designing efficient case-finding strategies, including the retrieval of previously diagnosed hepatitis C virus-infected who are lost to follow-up. Aims To trace and treat all lost to follow-up hepatitis C virus patients in the Utrecht region and create an efficient retrieval strategy that can be used in future (national) retrieval initiatives. Methods Positive hepatitis C virus diagnostic tests (anti-hepatitis C virus IgG or hepatitis C virus-RNA) from the laboratory of all four hospitals and one central laboratory for primary care diagnostics in the province of Utrecht from 2001 to 2015 were linked to clinical records. Untreated patients with available contact information were deemed eligible for retrieval and invited for reevaluation with (virology) blood tests, fibroscan measurement and possible direct-acting antiviral therapy. Main results After screening all hepatitis C virus diagnostics, 1913 chronic hepatitis C virus-infected were identified of which 14.1% (n = 269) were invited back into care. Overall, 17.4% was traced with the highest yield (28.3%) in those who lived in the Utrecht province. Through renewed patient assessments, 42 chronic hepatitis C virus infections were re-identified (76% with a history of intravenous drug use, 24% with Metavir F3-F4). Until now, 59% has either scheduled or initiated direct-acting antiviral therapy. Conclusion The retrieval of previously diagnosed hepatitis C virus patients through screening of laboratory diagnostics from the past is feasible and should be pursued for further control and reduction of hepatitis C virus infection. Retrieval is most successful when performed regionally. Lay summary To completely eliminate chronic hepatitis C virus (HCV) infection and prevent complications, undiagnosed and also previously diagnosed but lost to follow-up (LFU) HCV patients have to be brought (back) into care for therapy. Retrieval of LFU HCV patients through screening of laboratory diagnostics from the past is feasible and most successful when performed regionally.

ObjectivesSeveral studies focused on the association between alcohol consumption and amyotrophic lateral sclerosis (ALS), although with inconsistent findings. Antioxidants may play a role since lyophilised red wine was found to prolong SOD1 mice lifespan. The aim of this international population-based case–control study performed in Ireland, The Netherlands and Italy was to assess the role of alcohol, and red wine in particular, in developing ALS.MethodsEuro-MOTOR is a case–control study where patients with incident ALS and controls matched for gender, age and area of residency were recruited in a population-based design. Logistic regression models adjusted for sex, age, cohort, education, leisure time physical activity, smoking, heart problems, hypertension, stroke, cholesterol and diabetes were performed.Results1557 patients with ALS and 2922 controls were enrolled in the study. Exposure to alcohol drinking was not significantly associated with ALS risk. A stratified analysis of exposure to alcohol by cohort revealed significant ORs in The Netherlands and in Apulia, with opposite directions (respectively 0.68 and 2.38). With regard to red wine consumption, only in Apulia the double-fold increased risk (OR 2.53) remained significant. A decreased risk was found for current alcohol drinkers (OR 0.83), while a significantly increased risk was detected among former drinkers (OR 1.63). Analysis of cumulative exposure to alcohol revealed no significant associations with ALS risk.ConclusionWith few exceptions, no significant association was found between alcohol consumption and ALS. The study of the association between alcohol and ALS requires a thorough exploration, especially considering the role of different type of alcoholic beverages.

Introduction This study investigates the extent to which Ontario hospital librarians and library resources support researchers and describe the librarians' participation in research capacity building within their institutions. Methods A 16-question SurveyMonkey™ web-based survey questionnaire was disseminated via email to 53 potential participants consisted of library directors, managers and solo librarians. Results The response rate was 60%. The number of researchers supported by librarians ranged from 10 or less to 76 or more researchers in the past 10 months. Librarians supported a variety of scholarly research outputs, assisting researchers with journal articles being the most frequently supported activity. The top three library resources used to support researchers were licensed electronic journals, print collections and expert librarian searches. One of the reported ways librarians received training to better assist researchers was via online continuing education.Discussion As others have reported, there was a predominance of support for literature studies including literature reviews and systematic reviews. Surprisingly, some librarians reported that they had all the databases or resources they needed to support research, while an alarming 79 per cent of respondents reported not having access to all the databases and resources they needed. Lack of access to databases or online resources may have a negative effect on the quality of research the librarians provided. Raising the awareness of the role of the librarian in supporting researchers in the hospital setting can inform the health sciences librarians' professional practices and provide evidence of the library's participation in the research capacity building of the organization.

Essentials von Willebrand Factor (VWF) and ADAMTS13 may affect early injury after subarachnoid hemorrhage (SAH). Early brain injury was assessed in VWF−/−, ADAMTS13−/− and recombinant (r) ADAMTS13 treated mice. VWF−/− and rADAMTS13 treated mice had less brain injury than ADAMTS13−/− and wild-type mice. Early administration of rADAMTS13 may improve outcome after SAH by reducing early brain injury. Summary: Background Early brain injury is an important determinant of poor functional outcome and case fatality after aneurysmal subarachnoid hemorrhage (SAH), and is associated with early platelet aggregation. No treatment exists for early brain injury after SAH. We investigated whether von Willebrand factor (VWF) is involved in the pathogenesis of early brain injury, and whether ultra-early treatment with recombinant ADAMTS-13 (rADAMTS-13) reduces early brain injury after experimental SAH. Methods Experimental SAH in mice was induced by prechiasmatic injection of non-anticoagulated blood from a littermate. The following experimental SAH groups were investigated: C57BL/6J control (n = 21), VWF−/− (n = 25), ADAMTS-13−/− (n = 23), and C57BL/6J treated with rADAMTS-13 (n = 26). Mice were killed at 2 h after SAH. Primary outcome measures were microglial activation (IBA-1 surface area) and neuronal injury (number of cleaved caspase-3-positive neurons). Results As compared with controls, microglial activation was decreased in VWF−/− mice (mean difference of − 20.0%, 95% confidence interval [CI] − 4.0% to − 38.6%), increased in ADAMTS-13−/− mice (mean difference of + 34.0%, 95% CI 16.2–51.7%), and decreased in rADAMTS-13-treated mice (mean difference of − 22.1%, 95% CI − 3.4% to − 39.1%). As compared with controls (185 neurons, interquartile range [IQR] 133–353), neuronal injury in the cerebral cortex was decreased in VWF−/− mice (63 neurons, IQR 25–78), not changed in ADAMTS-13−/− mice (53 neurons, IQR 26–221), and reduced in rADAMTS-13-treated mice (45 neurons, IQR 9–115). Conclusions Our findings suggest that VWF is involved in the pathogenesis of early brain injury, and support the further study of rADAMTS-13 as a treatment option for early brain injury after SAH.

Background and purpose Mechanisms underlying cognitive impairment in patients with small vessel disease (SVD) are still unknown. We hypothesized that cognition is affected by the cumulative effect of multiple SVD-related lesions on brain connectivity. We therefore assessed the relationship between the total SVD burden on MRI, global brain network efficiency, and cognition in memory clinic patients with vascular brain injury. Methods 173 patients from the memory clinic of the University Medical Center Utrecht underwent a 3 T brain MRI scan (including diffusion MRI sequences) and neuropsychological testing. MRI markers for SVD were rated and compiled in a previously developed total SVD score. Structural brain networks were reconstructed using fiber tractography followed by graph theoretical analysis. The relationship between total SVD burden score, global network efficiency and cognition was assessed using multiple linear regression analyses. Results Each point increase on the SVD burden score was associated with 0.260 [−0.404 - -0.117] SD units decrease of global brain network efficiency (p, Highlights • Increasing small vessel disease burden (SVD) related to decreasing network efficiency. • Network efficiency mediates association between SVD burden and processing speed. • Cumulative effect of SVD might partly affect cognition through disrupted connectivity.

Der Fachinformationsdienst Geschichtswissenschaft bietet deutschlandweit Unterstützung für Historikerinnen und Historiker. Die Beschaffung von Spezialliteratur, der Zugang zu Fachdatenbanken, die Open-Access-Bereitstellung einschlägiger Rezensionen und ein umfangreiches Rechercheportal sind einige der angebotenen Dienstleistungen. Das gemeinsame Projekt der Bayerischen Staatsbibliothek und der Bibliothek des Deutschen Museums, von der die Subdisziplinen Technik-, Umwelt- und Naturwissenschaftsgeschichte betreut werden, besteht seit 2016 und wird von der Deutschen Forschungsgemeinschaft gefördert. Der vorliegende Aufsatz beschreibt die Genese des FID und gibt einen Überblick über das Dienstleistungsportfolio der ersten Förderphase. (Notiz zur Lizenzangabe: Zweitveröffentlichung nach § 38 (4) UrhG. Download und Ausdruck für den persönlichen, nicht-kommerziellen Gebrauch möglich; keine Weiterverbreitung; keine Bearbeitung.) The Specialised Information Service for Historical Sciences offers support for historians throughout Germany. The acquisition of subject specific literature, access to specialized databases, the open access provision of relevant reviews and an extensive research portal are some of the provided services. The joint project of the Bavarian State Library and the library of the Deutsches Museum, which is repsonsible for the subdisciplines of history of technology, environmental history, and history of exact sciences, has been in operation since 2016 and is funded by the German Research Foundation. This paper describes the genesis of the Specialised Information Service and provides an overview of the service portfolio of the first funding phase. (Note on the license statement: Self archived publication according to § 38 (4) UrhG. Download and printout possible for private non-commercial use; no further distribution; no editing.)

Aim This study aimed to estimate long-term impairment attributable to congenital cytomegalovirus infection (cCMV). Method This nationwide cohort study retrospectively assessed cCMV in children born in 2008 in the Netherlands, testing 31 484 stored neonatal dried blood spots. Extensive medical data of cCMV-positive children (n=133) and matched cCMV-negative comparison children (n=274) up to 6 years of age were analysed. Results Moderate to severe long-term impairment was diagnosed in 24.8% (33 out of 133) of all cCMV-positive children (53.8% in symptomatic, 17.8% in asymptomatic), compared with 12.0% (33 out of 274) of cCMV-negative children. Sensorineural hearing loss was seen only in five cCMV-positive children (3.8%). Developmental delays were diagnosed more often in cCMV-positive children than cCMV-negative children: motor (12.0% vs 1.5%), cognitive (6.0% vs 1.1%), and speech–language (16.5% vs 7.3%). Long-term impairment in multiple domains was more frequent in symptomatic (19.2%) and asymptomatic (8.4%) cCMV-positive children than cCMV-negative children (1.8%). Interpretation Children with cCMV were twice as likely to have long-term impairment up to the age of 6 years, especially developmental delays and sensorineural hearing loss, than cCMV-negative comparison children, with a risk difference of 12.8%. These insights into the risk of cCMV-associated impairment can help optimize care and stimulate preventive measures. What this paper adds Congenital cytomegalovirus infection (cCMV) leads to impairment in 25% of cases. Fifty per cent of children with cCMV symptoms at birth have long-term impairment. The risk difference of moderate to severe long-term impairment between children with and without cCMV is 13%, attributable to cCMV. cCMV leads to motor, cognitive, and speech–language developmental delay in children.

Metastases undergo reconstruction Cancer cells from primary tumors can migrate to regional lymph nodes and distant organs. The prevailing model in oncology is that lymph node metastases give rise to distant metastases. This “sequential progression model” is the rationale for surgical removal of tumor-draining lymph nodes. Naxerova et al. used phylogenetic methods to reconstruct the evolutionary relationship of primary tumors, lymph node metastases, and distant metastases in 17 patients with colorectal cancer (see the Perspective by Markowitz). The sequential progression model applied to only one-third of the patients. In the other two-thirds, distant metastases and lymph node metastases originated from independent subclones within the primary tumor. Science , this issue p. 55 ; see also p. 35

In order to determine the impact of the epigenetic response to traumatic stress on post-traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development of PTSD symptoms in two prospective military cohorts (one discovery and one replication data set). In the first cohort consisting of male Dutch military servicemen (n=93), the emergence of PTSD symptoms over a deployment period to a combat zone was significantly associated with alterations in DNA methylation levels at 17 genomic positions and 12 genomic regions. Evidence for mediation of the relation between combat trauma and PTSD symptoms by longitudinal changes in DNA methylation was observed at several positions and regions. Bioinformatic analyses of the reported associations identified significant enrichment in several pathways relevant for symptoms of PTSD. Targeted analyses of the significant findings from the discovery sample in an independent prospective cohort of male US marines (n=98) replicated the observed relation between decreases in DNA methylation levels and PTSD symptoms at genomic regions in ZFP57, RNF39 and HIST1H2APS2. Together, our study pinpoints three novel genomic regions where longitudinal decreases in DNA methylation across the period of exposure to combat trauma marks susceptibility for PTSD.Molecular Psychiatry advance online publication, 20 June 2017; doi:10.1038/mp.2017.120. ispartof: Molecular Psychiatry vol:23 issue:5 pages:1145-1156 ispartof: location:England status: published

IntroductionSpace matters. We read space like we read people’s faces. Space is an instrument of collaboration and innovation. At the University of Michigan’s Institute for Clinical and Health Research (MICHR), a team was created to creatively and economically enhance our operating space into a flexible workspace that supports privacy, innovation, creativity, and most important, a culture of collaboration.MethodsThe team used a human-centered design process to creatively engage the staff at large into analyzing our existing space, identifying latent needs, proposing solutions, generating feedback, and economically building the rethought process.ResultsThe redesigned workspace embraces the differences among MICHR’s teams while encouraging collaboration and teamwork and keeping costs at a minimum. It has resulted in a flexible space that includes co-located teams, spaces dedicated to different work goals, an open area for collaboration, quiet zones for focused work, and better wayfinding.ConclusionsThrough our Rethink Space project, we hope to have demonstrated that, by initiating the project internally and by engaging the users of the space themselves in an empathetic, visual, and human-centered way, a space redesign can be undertaken economically while also leading to improved levels of employee and team satisfaction.

BACKGROUND: Adalimumab, a fully human anti-tumor necrosis factor α monoclonal antibody, is effective in the treatment of juvenile idiopathic arthritis (JIA). We tested the efficacy of adalimumab in the treatment of JIA-associated uveitis.METHODS: In this multicenter, double-blind, randomized, placebo-controlled trial, we assessed the efficacy and safety of adalimumab in children and adolescents 2 years of age or older who had active JIA-associated uveitis. Patients who were taking a stable dose of methotrexate were randomly assigned in a 2:1 ratio to receive either adalimumab (at a dose of 20 mg or 40 mg, according to body weight) or placebo, administered subcutaneously every 2 weeks. Patients continued the trial regimen until treatment failure or until 18 months had elapsed. They were followed for up to 2 years after randomization. The primary end point was the time to treatment failure, defined according to a multicomponent intraocular inflammation score that was based on the Standardization of Uveitis Nomenclature criteria.RESULTS: The prespecified stopping criteria were met after the enrollment of 90 of 114 patients. We observed 16 treatment failures in 60 patients (27%) in the adalimumab group versus 18 treatment failures in 30 patients (60%) in the placebo group (hazard ratio, 0.25; 95% confidence interval [CI], 0.12 to 0.49; PCONCLUSIONS: Adalimumab therapy controlled inflammation and was associated with a lower rate of treatment failure than placebo among children and adolescents with active JIA-associated uveitis who were taking a stable dose of methotrexate. Patients who received adalimumab had a much higher incidence of adverse events and serious adverse events than those who received placebo. (Funded by the NIHR Health Technology Assessment Programme and Arthritis Research UK; SYCAMORE EudraCT number, 2010-021141-41 .).

The thalamus acts as a central integrator for processing and relaying sensory and motor information to and from the cerebral cortex, and the habenula plays pivotal roles in emotive decision making by modulating dopaminergic and serotonergic circuits. These neural compartments are derived from a common developmental progenitor domain, called prosomere 2, in the caudal forebrain. Thalamic and habenular neurons exhibit distinct molecular profile, neurochemical identity, and axonal circuitry. However, the mechanisms of how their progenitors in prosomere 2 give rise to these two populations of neurons and contribute to the forebrain circuitry remains unclear. In this study, we discovered a previously unrecognized role for Tcf7l2, a transcription factor known as the canonical Wnt nuclear effector and diabetes risk-conferring gene, in establishing neuronal identity and circuits of the caudal forebrain. Using genetic and chemical axon tracers, we showed that efferent axons of the thalamus, known as the thalamocortical axons (TCAs), failed to elongate normally and strayed from their normal course to inappropriate locations in the absence of Tcf7l2. Further experiments with thalamic explants revealed that the pathfinding defects of Tcf7l2-deficient TCAs were associated at least in part with downregulation of guidance receptors Robo1 and Robo2 expression. Moreover, the fasciculus retroflexus, the main habenular output tract, was missing in embryos lacking Tcf7l2. These axonal defects may result from dysregulation of Nrp2 guidance receptor. Strikingly, loss of Tcf7l2 caused a post-mitotic identity switch between thalamic and habenular neurons. Despite normal acquisition of progenitor identity in prosomere 2, Tcf7l2-deficient thalamic neurons adopted a molecular profile of a neighboring forebrain derivative, the habenula. Conversely, habenular neurons failed to maintain their normal post-mitotic neuronal identity and acquired a subset of thalamic neuronal features in the absence of Tcf7l2. Our findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population, and provide a better understanding of the mechanism underlying neuronal specification, differentiation, and connectivity of the developing caudal forebrain.

Multiple recent examples highlight how stem cells can self-organize in vitro to establish organoids that closely resemble their in vivo counterparts. Single Lgr5+ mouse intestinal stem cells can be cultured under defined conditions forming ever-expanding epithelial organoids that retain cell polarization, cell type diversity and anatomical organization of the in vivo epithelium. Although exhibiting a remarkable level of self-organization, the so called ‘mini-guts’ have a closed cystic structure of microscopic size. Here, we describe a simple protocol to generate macroscopic intestinal tubes from small cystic organoids. Embedding proliferating organoids within a contracting floating collagen gel allows them to align and fuse to generate macroscopic hollow structures (‘tubes’) that are lined with a simple epithelium containing all major cell types (including functional stem cells) of the small intestine. Cells lining the central contiguous lumen closely resemble the epithelial cells on luminal villi in vivo, whereas buds that protrude from the main tube into the surrounding matrix closely resemble crypts. Thus, the remarkable self-organizing properties of Lgr5+ stem cells extend beyond the level of the microscopic cystic organoid to the next, macroscopic, level of tube formation.

Data management is a vital part of all research projects. Done well it can save time and stress as well as making the research process more efficient. This session will introduce participants to the basic elements of managing the information they use and create as part of their projects including how information can be backed up, stored and shared.

Presentation given at the CILIP Information Literacy Group Event "Exploring the Intersections of Information Literacy and Scholarly Communications". This presentation looks at the range of job roles available to librarians in scholarly communication and the skills they need to work in these roles. It also contains an activity designed to encourage the mapping of known information literacy skills on to existing scholarly communication job advertisements.

The pressure for increased research productivity to raise institutional ranking has shifted priorities for Indian universities. The role libraries can play in this scenario is of vital importance. Research Support from libraries needs to be examined along with how researchers are responding to this. The purpose of the study was to understand how aware and satisfied the researchers in AHSS (Arts, Humanities, Social Sciences) were regarding the Research Support provision of an Indian University Library (Anna Arignar Library). The authors surveyed the relationship between researchers and Library Research Support at an Indian university which had a high research ranking in the National Institute Ranking Framework (Bharathiar University). A structured questionnaire was used to collect data for the study. It was found that although researchers were comparatively satisfied with most of the traditional services and resources, they were unaware of newer, researcher-specific services like bibliometrics and Research Data Management. On the basis of findings, the authors recommended proactive participation of libraries in research process, and publicizing their services. The study helps understand needs of researchers with respect to the library, and how satisfied they are with the status quo.

With the recent advent of hybrid MRI-guided radiotherapy systems, continuous intra-fraction MR imaging for motion monitoring has become feasible. The ability to perform real-time custom image reconstructions is however often lacking. In this work we present a low-latency streaming solution, ReconSocket, which provides a real-time stream of k-space data from the magnetic resonance imaging (MRI) to custom reconstruction servers. We determined the performance of the data streaming by measuring the streaming latency (i.e. non-zero time delay due to data transfer and processing) and jitter (i.e. deviations from periodicity) using an ultra-fast 1D MRI acquisition of a moving phantom. Simultaneously, its position was recorded with near-zero time delay. The feasibility of low-latency custom reconstructions was tested by measuring the imaging latency (i.e. time delay between physical change and appearance of that change on the image) for several non-Cartesian 2D and 3D acquisitions using an in-house implemented reconstruction server. The measured streaming latency of the ReconSocket interface was ms. 98% of the incoming data packets arrived within a jitter range of 367 s. This shows that the ReconSocket interface can provide reliable real-time access to MRI data, acquired during the course of a MRI-guided radiotherapy fraction. The total imaging latency was measured to be 221 ms (2D) and 3889 ms (3D) for exemplary acquisitions, using the custom image reconstruction server. These imaging latencies are approximately equal to half of the temporal footprint (T acq/2) of the respective 2D and 3D golden-angle radial sequences. For radial sequences, it was previously showed that T acq/2 is the expected contribution of only the data acquisition to the total imaging latency. Indeed, the contribution of the non-Cartesian reconstruction to the total imaging latency was minor (