Back to Search
Start Over
Assessment of herd effects among women and heterosexual men after girls-only HPV16/18 vaccination in the Netherlands: A repeated cross-sectional study
- Source :
- International Journal of Cancer, 144(11), 2718-2727. Wiley-Liss Inc., Woestenberg, P J, Bogaards, J A, King, A J, Leussink, S, van der Sande, M A B, Hoebe, C J PA, van Benthem, B H B & on behalf of the Medical Microbiological Laboratories and the Public Health Services 2019, ' Assessment of herd effects among women and heterosexual men after girls-only HPV16/18 vaccination in the Netherlands: A repeated cross-sectional study ', International Journal of Cancer, vol. 144, no. 11, pp. 2718-2727 . https://doi.org/10.1002/ijc.31989, International Journal of Cancer, International Journal of Cancer, 144(11), 2718. Wiley-Liss Inc., International Journal of Cancer, 144(11), 2718-2727. Wiley
- Publication Year :
- 2019
-
Abstract
- Data on the impact of human papillomavirus (HPV) vaccination on the population HPV prevalence are largely obtained from women. We assessed the impact of the girls‐only HPV16/18 vaccination program in the Netherlands that started in 2009, on trends in HPV prevalence among women and heterosexual men, using data from the PASSYON study. In this cross‐sectional study, the HPV prevalence among 16‐ to 24‐year‐old visitors to sexually transmitted infection clinics was assessed in 2009, 2011, 2013, and 2015. We compared the genital postvaccination HPV prevalence with the prevaccination prevalence (2009) using Poisson GEE models. In total, we included 4,996 women and 1,901 heterosexual men. The percentage of women who reported to be vaccinated increased from 2.3% in 2009 to 37% in 2015. Among all women, the HPV16/18 prevalence decreased from 23% prevaccination to 15% in 2015 (adjusted prevalence ratio [aPR] 0.62, p trend < 0.01). Among heterosexual men, the HPV16/18 prevalence decreased from 17% prevaccination to 11% in 2015 (aPR 0.52, p trend < 0.01). Of the heterosexual men with a steady partner, HPV16/18 prevalence was lower among those whose steady partner had been vaccine‐eligible in the national immunization program (aPR 0.13). Among unvaccinated women, the HPV16/18 prevalence in 2015 was not different from prevaccination. The decreasing HPV16/18 prevalence among heterosexual men and the reduced HPV16/18 prevalence among heterosexual men with a vaccine‐eligible steady partner strongly suggests herd protection from girls‐only vaccination. Absence of notable herd effects among unvaccinated women 6 years postvaccination may be due to the moderate vaccine uptake among girls in the Netherlands.<br />What's new? Human papillomavirus (HPV) is a sexually transmitted virus that plays a causal role in the development of anogenital and oropharyngeal cancers in both men and women. The population‐level impact of HPV vaccination programs on the HPV prevalence has however mainly been studied in women. This study shows decreasing trends in the HPV16 and HPV18 prevalence among both women and heterosexual men after the introduction of a girls‐only HPV16/18 vaccination program in the Netherlands. The findings provide compelling evidence for herd protection in men. Because HPV16/18 are the most oncogenic types, HPV‐related cancers are expected to decline in both sexes after girls‐only HPV vaccination.
- Subjects :
- Male
Cancer Research
Outcome Assessment (Health Care)/statistics & numerical data
Cross-sectional study
Prevalence
Uterine Cervical Neoplasms
Gee
Men who have sex with men
0302 clinical medicine
Epidemiology
Outcome Assessment, Health Care
PROGRAM
Non-U.S. Gov't
human papillomavirus
Netherlands
education.field_of_study
Human papillomavirus 16
Uterine Cervical Neoplasms/immunology
Human papillomavirus 18
Research Support, Non-U.S. Gov't
public health
virus diseases
HUMAN-PAPILLOMAVIRUS VACCINATION
Human papillomavirus 18/immunology
PREVALENCE
Vaccination
Infectious Causes of Cancer
Oncology
INFECTIONS
030220 oncology & carcinogenesis
Female
HEALTH
BURDEN
Adult
medicine.medical_specialty
Adolescent
Population
Sexually Transmitted Diseases
Netherlands/epidemiology
IMMUNITY
Research Support
Mass Vaccination
03 medical and health sciences
Young Adult
SDG 3 - Good Health and Well-being
POPULATION-LEVEL IMPACT
medicine
Journal Article
Humans
Papillomavirus Vaccines
education
population effects
Papillomavirus Vaccines/administration & dosage
business.industry
Papillomavirus Infections
Sexually Transmitted Diseases/epidemiology
vaccination
Human papillomavirus 16/immunology
Cross-Sectional Studies
Papillomavirus Infections/epidemiology
Mass Vaccination/methods
Herd
herd protection
business
FEMALES
Demography
Program Evaluation
Subjects
Details
- ISSN :
- 00207136
- Volume :
- 144
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International Journal of Cancer
- Accession number :
- edsair.doi.dedup.....5dad29e57887b9e441cfe7b081f9d862