102 results on '"M. Oettel"'
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2. Interplay of orientational order and roughness in simulated thin film growth of anisotropically interacting particles
- Author
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E. Empting, N. Bader, and M. Oettel
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Soft Condensed Matter (cond-mat.soft) ,FOS: Physical sciences ,Condensed Matter - Soft Condensed Matter - Abstract
Roughness and orientational order in thin films of anisotropic particles are investigated using kinetic Monte Carlo simulations on a cubic lattice. Anisotropic next-neighbor interactions between the lattice particles were chosen to mimic the effects of shape anisotropy in the interactions of disc- or rod-like molecules with van-der-Waals attractions. Increasing anisotropy leads first to a preferred orientation in the film (which is close to the corresponding equilibrium transition) while the qualitative mode of roughness evolution (known from isotropic systems) does not change. At strong anisotropies, an effective step-edge (Ehrlich-Schwoebel) barrier appears and a non-equilibrium roughening effect is found, accompanied by re-ordering in the film which can be interpreted as the nucleation and growth of domains of lying-down discs or rods. The information on order and roughness is combined into a diagram of dynamic growth modes., Comment: 14 pages, 21 figures
- Published
- 2021
- Full Text
- View/download PDF
3. Hybride Fertigungsprozessketten Gießen-Additiv – Wie Aluminiumdruckguss gewinnbringend mit der additiven Fertigung kombiniert werden kann
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S. Flügel, A. Kleine, M. Oettel, and S. Polenz
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- 2020
4. Long Term Toxicological Studies on the Progestin STS 557
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H. Hoffmann, H. Hillesheim, J. Güttner, K. Stade, Eva-Maria Merbt, K. Holle, M. Oettel, J. Strecke, G. Hesse, U. Horn, U. Valentin, H. Lemke, K. Chemnitius, I. Schimmel, J. Deufrains, V. Hesse, E. Keil, G. Klinger, A. Stelzner, R. Furcht, P. Gaida, M. Anke, R. Dettmann, B. Kramp, and F. Robiller
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Male ,medicine.medical_specialty ,Time Factors ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Levonorgestrel ,Beagle ,Eating ,Dogs ,Endocrinology ,Oral administration ,Internal medicine ,Internal Medicine ,medicine ,Animals ,Nandrolone ,Progesterone Congeners ,business.industry ,Body Weight ,Norgestrel ,Organ Size ,General Medicine ,Glucose Tolerance Test ,Hyperplasia ,medicine.disease ,Hormones ,Rats ,Contraceptives, Oral, Combined ,medicine.anatomical_structure ,Toxicity ,Female ,Bone marrow ,business ,Progestin ,medicine.drug ,Hormone - Abstract
The toxicity of 17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9-dien-3-one (STS 557) was studied by its oral administration of 0.1, 1.0 or 10.0 mg/kg/day to Wistar rats for six months, and of 0.01, 0.1 or 1.0 mg/kg/day to beagle dogs for six months, respectively. Levonorgestrel at a dose of 1.0 mg/kg/day was used as the standard in the dog study. With respect to the progestational activity of the compound the main target organs were the hypophysis, the reproductive organs and the adrenals. Mammary hyperplasia was observed in dogs treated with STS 557 or levonorgestrel at the dose of 1.0 mg/kg/day, but in no case mammary nodules could be detected. At the dose of 1.0 mg/kg/day STS 557 and levonorgestrel were found to increase the plasma insulin response to i.v. glucose in bitches, but neither the mean blood glucose levels nor the glucose utilization were affected. Moreover, during administration of both steroids to dogs temporary changes in serum concentrations of triglycerides and total cholesterol were noted. The results obtained in rats and dogs from functional and morphological investigations did not reveal any toxic side effects of STS 557 on the liver, the kidneys, the bone marrow or on blood coagulation. The effects on the reproductive organs observed following STS 557 especially in dogs are related to both the hormonal effects of the compound and the specific response of the dog to potent progestagens.
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- 2009
5. Further Report on the Endocrinological Profile of Two Synthetic Estrogens with Antifertility Properties, STS 456 and STS 593
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H. Freund, T. I. Ivanenko, E. V. Pokrovskaya, M. Koch, V. P. Fedotov, A. Kurischko, and M. Oettel
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Male ,medicine.medical_specialty ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Estrogen receptor ,urologic and male genital diseases ,Binding, Competitive ,Mice ,Anabolic Agents ,Cytosol ,Endocrinology ,Estradiol Congeners ,Internal medicine ,Testis ,Internal Medicine ,medicine ,Animals ,Testosterone Congeners ,Estradiol ,Progesterone Congeners ,Estriol ,Chemistry ,Uterus ,Androgen Antagonists ,Biological activity ,General Medicine ,Hormones ,Rats ,Fertility ,Receptors, Estrogen ,Estrogen ,Vagina ,Female ,Rabbits ,hormones, hormone substitutes, and hormone antagonists ,Hormone - Abstract
Two synthetic estrogens, STS 456 and STS 593, with noteworthy post-coital antifertility properties in the rat were studied for their estrogenic, antiestrogenic, progestagenic, antiprogestagenic, antigonadotrophic, androgenic and antiandrogenic effects in laboratory animals. Beside their weak estrogenic activity which corresponds to their slight affinity to the uterine estrogen receptor in the rat, both steroids show remarkable antiestrogenic effects. No progestagenic, androgenic and antiandrogenic effects were found but STS 593 showed some antiprogestagenic activity. The antigonadotrophic efficacy of STS 456 was relatively high while STS 593 was scarcely active. The results are discussed with respect to possible application of these drugs for interceptive purposes.
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- 2009
6. Euro Area Governance and Beyond
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Johanna M. Oettel
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Market economy ,Sociology and Political Science ,Economy ,Corporate governance ,Political science ,Political Science and International Relations - Published
- 2009
7. High-dose pilot study with the novel progestogen dienogestin patients with endometriosis
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M. Oettel, Adolf E. Schindler, A. Henkel, Bernd Christensen, and C. Moore
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Adult ,medicine.medical_specialty ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,media_common.quotation_subject ,Endometriosis ,Urology ,Pilot Projects ,Fertility ,Statistics, Nonparametric ,chemistry.chemical_compound ,Hormone Antagonists ,Endocrinology ,medicine ,Humans ,Nandrolone ,Laparoscopy ,media_common ,Danazol ,Gynecology ,Progestogen ,medicine.diagnostic_test ,business.industry ,Obstetrics and Gynecology ,medicine.disease ,Treatment Outcome ,Dienogest ,chemistry ,Female ,business ,Progestin ,medicine.drug ,Hormone - Abstract
High-dose dienogest (20 mg/day) was used for the treatment of endometriosis in women aged 18-52 years after laparoscopic and histological diagnosis of endometriosis and staging according to the revised American Fertility Society criteria. Treatment efficacy was analyzed objectively by second-look laparoscopy, and serum hormone measurements and evaluation of endometriosis-related symptoms were performed done and side-effects recorded. Compared with other high-dose progestin therapies, treatment with dienogest was shown to be effective even in stage IV endometriosis. The side-effect profile of the high-dose dienogest treatment appears to be highly favorable compared with other treatments. Neither the menopausal symptoms caused by therapy with gonadotropin-releasing hormone agonists nor the adverse androgen-related effects induced by danazol were observed. Therefore, long-term high-dose dienogest therapy can be recommended particularly for women with progressive endometriosis.
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- 2006
8. Clinical experience with the new long-acting injectable testosterone undecanoate. Report on the educational symposium on the occasion of the 5th World Congress on the Aging Male, 9–12 February 2006, Salzburg, Austria
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Alvaro Morales, M. Oettel, Michael Zitzmann, Eberhard Nieschlag, Markus Schubert, and Aksam Yassin
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medicine.medical_specialty ,Testosterone - serum ,business.industry ,Aging male ,Physiology ,medicine.disease ,Regimen ,Erectile dysfunction ,Long acting ,Endocrinology ,Internal medicine ,Testosterone enanthate ,Androgen deficiency ,medicine ,Geriatrics and Gerontology ,business ,Testosterone - Abstract
This symposium report summarizes first extensive clinical findings with injectable testosterone undecanoate (Nebido®) in hypogonadal patients showing clinical symptoms of androgen deficiency with or without erectile dysfunction (ED). This new testosterone formulation (1000 mg testosterone undecanoate in 4 ml castor oil) possesses nearly ideal long-term kinetics, i.e. sustained close mimicking of eugonadal testosterone serum levels without supra- or sub-physiological serum concentrations. The generally accepted administration scheme recommends the second injection 6 weeks after the first one followed by further injections every 12 weeks. Applying this regimen, administration intervals are drastically reduced in comparison to conventional i.m. testosterone preparations (e.g. about 16 injections of testosterone enanthate vs. 4–5 injections of testosterone undecanoate per year). Depending on the testosterone serum levels, individualized therapy is possible by shortening (every 10 weeks) or prolonging (every 1...
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- 2006
9. Dehydroepiandrosterone Treatment in the Aging Male – What Should the Urologist Know?
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C.E. Hoesl, A. Römmler, M. Oettel, J. D. Fauteck, and Farid Saad
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Male ,Aging ,medicine.medical_specialty ,Hormone Replacement Therapy ,medicine.drug_class ,Urology ,MEDLINE ,Physiology ,Dehydroepiandrosterone ,Cardiovascular Physiological Phenomena ,Hormone replacement therapy (female-to-male) ,Internal medicine ,Androgen deficiency ,Humans ,Medicine ,Clinical Trials as Topic ,business.industry ,Penile Erection ,Androgen ,medicine.disease ,Clinical trial ,Endocrinology ,Ageing ,Dietary Supplements ,Sexual function ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Objective: Dehydroepiandrosterone (DHEA) has attracted considerable attention as a means against the decrements of aging. This review will summarize clinical studies evaluating DHEA as a treatment option for age-related conditions and diseases. Methods: Literature search of PubMed documented publications and abstracts from meetings. Results: The collected data indicate that DHEA supplementation to counteract its gradual decrease over age is beneficiary. Positive effects on the cardiovascular system, body composition, BMD, the skin, the CNS, and the immune system have been reported. Improvement of sexual function by DHEA has been demonstrated. Conclusion: Although long-term clinical trials (applying the standards of evidence-based methods) are not available at present, the consistency of the data and the extensive practical experience may justify the use of DHEA in aging men given the rules of classical endocrinology are thoroughly followed including diagnosis based on clinical picture and biochemical evidence, compliance to periodic evaluations, and individual dose adjustment to maintain serum concentrations in the physiological range of young males. Being one among other important hormonal factors, DHEA can delay and correct age-related disorders only to a certain degree.
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- 2005
10. Progesterone: the forgotten hormone in men?
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M. Oettel and A. K. Mukhopadhyay
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Male ,medicine.medical_specialty ,Neuroactive steroid ,business.industry ,medicine.drug_class ,Prostate ,Urogenital System ,Progesterone secretion ,Luteal phase ,Gonadotropin secretion ,Endocrinology ,Internal medicine ,Progesterone receptor ,medicine ,Animals ,Humans ,Female ,Progestins ,Geriatrics and Gerontology ,business ,Receptor ,Progestin ,Progesterone ,Hormone - Abstract
'Classical' genomic progesterone receptors appear relatively late in phylogenesis, i.e. it is only in birds and mammals that they are detectable. In the different species, they mediate manifold effects regarding the differentiation of target organ functions, mainly in the reproductive system. Surprisingly, we know little about the physiology, endocrinology, and pharmacology of progesterone and progestins in male gender or men respectively, despite the fact that, as to progesterone secretion and serum progesterone levels, there are no great quantitative differences between men and women (at least outside the luteal phase). In a prospective cohort study of 1026 men with and without cardiovascular disease, we were not able to demonstrate any age-dependent change in serum progesterone concentrations. Progesterone influences spermiogenesis, sperm capacitation/acrosome reaction and testosterone biosynthesis in the Leydig cells. Other progesterone effects in men include those on the central nervous system (CNS) (mainly mediated by 5alpha-reduced progesterone metabolites as so-called neurosteroids), including blocking of gonadotropin secretion, sleep improvement, and effects on tumors in the CNS (meningioma, fibroma), as well as effects on the immune system, cardiovascular system, kidney function, adipose tissue, behavior, and respiratory system. A progestin may stimulate weight gain and appetite in men as well as in women. The detection of progesterone receptor isoforms would have a highly diagnostic value in prostate pathology (benign prostatic hypertrophy and prostate cancer). The modulation of progesterone effects on typical male targets is connected with a great pharmacodynamic variability. The reason for this is that, in men, some important effects of progesterone are mediated non-genomically through different molecular biological modes of action. Therefore, the precise therapeutic manipulation of progesterone actions in the male requires completely new endocrine-pharmacological approaches.
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- 2004
11. Testosterone metabolism, dose–response relationships and receptor polymorphisms: selected pharmacological/toxicological considerations on benefits versus risks of testosterone therapy in men
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M. Oettel
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Male ,Drug ,medicine.medical_specialty ,Dose-Response Relationship, Drug ,Hormone Replacement Therapy ,business.industry ,Hypogonadism ,media_common.quotation_subject ,Physiology ,Testosterone (patch) ,Pharmacology ,Androgen receptor ,Androgen Therapy ,Epidemiology ,Toxicity ,medicine ,Humans ,Testosterone ,Animal studies ,Geriatrics and Gerontology ,business ,media_common ,Transdermal - Abstract
In this review selected toxicological problems related to testosterone therapy in hypogonadal men are discussed. Applying "classical" pharmacological/toxicological findings (e.g. animal studies on short- and long-term toxicity) to clinical situations is not very helpful. Molecular biological knowledge and especially evaluation of epidemiological studies, as well as intervention studies, on testosterone therapy in hypogonadal men are more useful. Potential risks include overdosage for lifestyle reasons, e.g. excessive muscle building and reduction of visceral obesity, when erythrocytosis occurs concomitantly. Modern galenic formulations of testosterone administration (e.g. transdermal gel, suitable testosterone esters for intramuscular application and newer oral preparations) avoid supraphysiological serum concentrations, therefore significantly reducing the toxicological risk. A hypothetical model of the toxicological risks of testosterone therapy is given that is based on the influence of testosterone metabolism (aromatization vs. reduction) of the respective parameter/target chosen. Finally, the great influence of polymorphisms of the androgen receptor on the assessment of toxicological risk and on the individualization of androgen therapy is shown. Already existing national, continental and international guidelines or recommendations for the testosterone therapy should be harmonized.
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- 2003
12. Is there a role for estrogens in the maintenance of men's health?
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M. Oettel
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medicine.medical_specialty ,biology ,Bone density ,medicine.drug_class ,business.industry ,Estrogen secretion ,Estrogen receptor ,Carbohydrate metabolism ,chemistry.chemical_compound ,Mood ,Endocrinology ,chemistry ,Estrogen ,Internal medicine ,medicine ,biology.protein ,Phytoestrogens ,Geriatrics and Gerontology ,Aromatase ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
This paper gives an overview of our own studies and the literature on the biosynthesis and metabolism of estrogens in elderly men, the estrogen action in the male, and the clinical usefulness of estrogen therapy, including the phytoestrogens. Finally, the paper includes a short review of our knowledge of xenoestrogens and men's sexual health. A strong estrogen-deficient status is seen in male patients with mutations of the estrogen receptors or in cases of deviations of the aromatase gene. On the other hand, there are no clear age-dependent changes in estrogen secretion. But, in men with disorders of glucose metabolism and also of increased body mass index, the serum estrogen concentrations are significantly elevated. There are also strong positive correlations between serum estrogen levels and bone density, including prevalence of fractures and mood in men. New fields of interest are natural fatty esters of endogenous estrogens, e.g. lipoprotein-associated estrogens, and the role and clinical significanc...
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- 2002
13. What is past is prologue: estrogen/progestin replacement tomorrow
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C. Holz, M. Oettel, V. Patchev, Walter Elger, P. Lähteenmäki, and T. Gräser
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medicine.medical_specialty ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Obstetrics and Gynecology ,Drospirenone ,Pharmacology ,Biology ,medicine.disease ,Menopause ,chemistry.chemical_compound ,Endocrinology ,Dienogest ,chemistry ,Selective estrogen receptor modulator ,Oral administration ,Estrogen ,Internal medicine ,medicine ,Phytoestrogens ,Progestin ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
The ‘ depletion’ of the granulosa cells and associated cessation of the secretion of 17 b-estradiol by the ovary mark the menopause. The well-known 17 b-estradiol deficiency syndrome occurs. Replacement with 17 b-estradiol (in the most varying dosages and in different administration regimens) will remain the ‘ gold standard’ in times to come. Combination with a progestin-delivering intrauterine system can optimize 17 b-estradiol replacement. Future developments include dietary measures (so-called ‘ nutriceuticals’ ) or the potency-enhanced phytoestrogens, essentially improved selective estrogen receptor modulators (SERMs) including central nervous system-focused estrogens with reduced peripheral action, and the estrogen sulfamates with a unique pharmacokinetic pattern after oral administration (‘ oral patch’ ). In the field of progestins, the so-called hybrid progestins (e.g. dienogest, drospirenone, and the selective progesterone receptor modulators (mesoprogestins)) will probably predominate. A very attractive approach is the use of selective androgen-receptor modulators (SARMs) as non-masculinizing androgens.
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- 2001
14. Antiatherogenic effects of 17β-estradiol and 17α-estradiol and its derivative J811 in cholesterol-fed rabbits with thyroid inhibition
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M. Oettel, Yury Popov, I. Chirkina, D. Hübler, A. Chirkin, Elena Naruta, W. Römer, Oxana Lukivskaya, and Vyacheslav Buko
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medicine.medical_specialty ,medicine.drug_class ,business.industry ,Cholesterol ,Antithyroid agent ,medicine.medical_treatment ,Thyroid ,Cholic acid ,Obstetrics and Gynecology ,General Medicine ,17beta estradiol ,Thiouracil ,chemistry.chemical_compound ,Dose–response relationship ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Estrogen ,Internal medicine ,medicine ,business - Abstract
Objective: The aim of this study was to investigate the antiatherogenic effects of 17β-estradiol and 17α-estradiol and its derivative J811 (estra-1,3,5(10),8-tetraene-3, 17α-diol), having a non-feminizing effect and high antioxidant potential, in male rabbits. Experimental design: Male White-Russian rabbits weighing 2.1-2.6 kg were fed either a standard or a high-cholesterol (200 mg/kg) diet, with thyroid function-inhibiting thiouracil (20 mg/kg) combined with cholic acid (40 mg/kg) administered daily in sunflower oil for 3 months. During the last month of the study, estrogens were administered by gavage at a dose of 0.02 or 0.1 mg/kg. Results and conclusions: All three estrogens exerted remarkable antiatherosclerotic effects. Decreases in serum and aortic-wall lipid parameters and the index of atherogenicity were dependent on estrogen dose. Morphological evaluation of the aortic wall (height of plaques, size of plaque relative to aortic half-circumference) showed only weak therapeutic effects with all th...
- Published
- 2001
15. 17 alpha-oestradiol and 17 beta-oestradiol do not affect basal and follicle-stimulating hormone-stimulated inhibin B secretion by highly purified rat Sertoli cells
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U. C. Hipler, W. Roemer, V. Patchev, G. Schreiber, M. Oettel, and J. Berlau
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Male ,endocrine system ,medicine.medical_specialty ,medicine.drug_class ,Urology ,Biology ,Testicle ,Follicle-stimulating hormone ,Basal (phylogenetics) ,Endocrinology ,Internal medicine ,medicine ,Animals ,Secretion ,skin and connective tissue diseases ,Cells, Cultured ,Sertoli Cells ,Estradiol ,Prostatic Secretory Proteins ,General Medicine ,Sertoli cell ,Rats ,medicine.anatomical_structure ,Estrogen ,Follicle Stimulating Hormone ,Gonadotropin ,Peptides ,hormones, hormone substitutes, and hormone antagonists ,Hormone - Abstract
The effects of 17 alpha-oestradiol and 17 beta-oestradiol on basal and follicle-stimulating hormone (FSH)-stimulated inhibin B secretion by rat Sertoli cells were studied. Sertoli cells were isolated and cultivated from testes of 18-day-old Wistar rats in the presence and absence of FSH and different doses of oestrogens. On day 4 of culture, secreted inhibin was measured by enzyme-linked immunosorbent assay. Neither 17 alpha-oestradiol nor 17 beta-oestradiol had any effect on the secreted inhibin level in either the presence or absence of FSH. It is concluded that these oestradiols do not play an essential role in regulatory processes involving inhibin or FSH.
- Published
- 2000
16. Effects of two oral contraceptives on plasma levels of insulin-like growth factor I (IGF-I) and growth hormone (hGH)
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M. Oettel, Balogh A, G. Klinger, G Gräser, E Kauf, and R Vollanth
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medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Levonorgestrel ,Ethinyl Estradiol ,Insulin-like growth factor ,chemistry.chemical_compound ,Basal (phylogenetics) ,Oral administration ,Internal medicine ,Ethinylestradiol ,Contraceptive Agents, Female ,medicine ,Humans ,Nandrolone ,Insulin-Like Growth Factor I ,Progestogen ,Human Growth Hormone ,business.industry ,Obstetrics and Gynecology ,Contraceptives, Oral, Combined ,Insulin-Like Growth Factor Binding Protein 3 ,Endocrinology ,Reproductive Medicine ,Dienogest ,chemistry ,Linear Models ,Female ,business ,Hormone ,medicine.drug - Abstract
In 18 healthy women, the effect of two oral contraceptives (OCs) on insulin-like growth factor (IGF-I) and its binding protein-3 (IGFBP-3) and growth hormone (hGH) plasma level were studied before and after intake of either of two OC formulations over 21 days, one containing 2 mg dienogest and 0.03 mg ethinylestradiol (group A) and the other 0.125 mg levonorgestrel and 0.03 mg ethinylestradiol (group B). There was a reduction of the mean IGF-I concentration of 30% (p = 0.008) in the women receiving dienogest-containing pills and 12% (p = 0.006) in women taking the levonogestrel-containing preparation. This difference between drug groups was statistically significant (p = 0.002). A correlation between the control values and the basal-treatment difference (r = 0.945; p = 0.000) was observed only in women of group A. Between basal and treatment cycles the mean plasma levels of hGH remained unchanged in both groups tested, but the 23.5-h integrated mean hGH plasma concentrations (AUC0–23.5h) were significantly elevated by 36% (p = 0.016) in comparison to basal values before treatment only in women receiving the levonorgestrel-containing pills. Also, in the women who received the dienogest-containing preparation, the changes of integrated mean plasma level were inversely associated with the control values (r = −0.723; p = 0.025). Neither in group A nor in group B was the mean plasma level of IGFB-3 changed. In conclusion: the results of the present analysis indicate that hormonal contraceptives can modulate the GH and IGF-I-axis in the reproductive age. Probably the androgenic progestogen levonorgestrel (0.125 mg/day) opposes the estrogen-induced action. In the women who took the dienogest-containing formulations (anti-androgenic progestogen—group A), the extent of individual changes (hGh and IGF-I) depends on the basal level prior to pill intake. Further studies, especially of long-term intake of OCs, are necessary to confirm these results and to assess the practical relevance for possible effects on connective tissue and bone.
- Published
- 2000
17. Continuous-combined treatment of the menopause with combinations of oestradiol valerate and dienogest — a dose-ranging study
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T. Graser, A.O Mück, M Oettel, A Müller, U Mellinger, and Theodor H. Lippert
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Adult ,medicine.medical_specialty ,Hormone Replacement Therapy ,medicine.medical_treatment ,Urology ,Endometrium ,Valerate ,General Biochemistry, Genetics and Molecular Biology ,chemistry.chemical_compound ,Germany ,medicine ,Humans ,Nandrolone ,Aged ,Gynecology ,chemistry.chemical_classification ,Estrogens, Conjugated (USP) ,Dose-Response Relationship, Drug ,Estradiol ,Progesterone Congeners ,medicine.diagnostic_test ,business.industry ,Estradiol valerate ,Obstetrics and Gynecology ,Hormone replacement therapy (menopause) ,Middle Aged ,medicine.disease ,Dose-ranging study ,Menopause ,medicine.anatomical_structure ,Dienogest ,chemistry ,Drug Therapy, Combination ,Female ,business ,medicine.drug ,Endometrial biopsy - Abstract
Objectives: To determine the progestational efficacy of continuous treatment with various doses of dienogest, combined with oestradiol valerate, on the basis of endometrial histology, effect on climacteric symptoms and bleeding profile in postmenopausal women. Methods: Patients were randomised to one of five fixed-combination treatments, oestradiol valerate 2.0 mg plus dienogest 0.5, 1.0, 2.0, 3.0 or 4.0 mg. Efficacy was assessed by endometrial biopsy, menstrual charts and change in climacteric symptoms. Results: The endometrium was classified as atrophic in 20.0, 31.3, 25.0, 55.6 and 57.1% of patients in the 0.5, 1.0, 2.0, 3.0 and 4.0 mg dienogest groups, respectively. The frequency of uterine bleeding was dose-dependent. The most favourable bleeding profile was seen in the 3.0 mg dienogest group, whereas the lower doses of dienogest had advantages with respect to the efficacy of the combined preparation. Conclusions: Dienogest 2.0 and 3.0 mg are the optimal doses for combination with 2.0 mg oestradiol valerate for continuous-combined hormone replacement therapy.
- Published
- 2000
18. Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells
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Peter Riederer, Eva Ahlbom, W. Römer, D. Blum-Degen, M. Oettel, M.E. Götz, Sten Orrenius, Boris Zhivotovsky, and Sandra Ceccatelli
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chemistry.chemical_classification ,Reactive oxygen species ,Programmed cell death ,Cerebellum ,biology ,Estrogen receptor ,medicine.disease_cause ,medicine.disease ,Cell biology ,Cellular and Molecular Neuroscience ,medicine.anatomical_structure ,chemistry ,Biochemistry ,Apoptosis ,medicine ,biology.protein ,Cell damage ,Oxidative stress ,Caspase - Abstract
Oxidative stress is considered to be an important pathophysiological condition to promote cell death in a broad variety of disorders, such as cardiovascular and neurodegenerative diseases. Scavestrogens, structurally derived from estradiol, are potent radical scavengers and inhibitors of iron-induced cell damage in vitro. In this study the potential cytoprotective effects of the so-called scavestrogen estra-1,3,5(10),8-tetraene-3,17alpha-diol, J 811, was tested using rat cerebellar granule cells (CGCs) exposed to 25 or 50 microM hydrogen peroxide (H2O2). H2O2-induced apoptotic cell death was detected by the appearance of high molecular weight DNA fragments and nuclear condensation. The addition of J 811 before or shortly after the exposure to H2O2 prevented CGC apoptosis in a dose-dependent manner. The estrogen receptor antagonist ICI 182.780 failed to prevent the protective effect of J 811, suggesting that the latter is not dependent on estrogen receptor activation. The lack of protection against apoptosis caused by colchicine suggests that J 811 is neither interfering with the activation of caspase-3, nor acting downstream of caspase-3. Therefore, the protective effect observed against H2O2 seems to be upstream caspases activation, pointing to a scavenging action of J 811. Thus the scavestrogen J 811 is a powerful antioxidant able to interfere with radical-mediated cell death and is potentially useful in diseases where reactive oxygen species are involved.
- Published
- 1999
19. The pharmacological profile of dienogest
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D. Hübler, H. Zimmermann, M. Oettel, Walter Elger, G. Kaufmann, H. Breitbarth, L. Sobek, C. Moore, T. Graser, V. Patchev, J. Schröder, and W Römer
- Subjects
chemistry.chemical_compound ,Reproductive Medicine ,Dienogest ,chemistry ,Pharmacokinetics ,medicine.drug_class ,business.industry ,medicine ,Obstetrics and Gynecology ,Pharmacology (medical) ,Pharmacology ,business ,Progestin - Abstract
Dienogest is the first non-alkylated 19-norprogestin on the market. This so-called hybrid progestin combines the typical qualities of the modern 19-norprogestins with those of natural progesterone ...
- Published
- 1999
20. Mechanisms of relaxation of rat aorta in response to progesterone and synthetic progestins
- Author
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S Wagner, M Oettel, E Glusa, and T Gräser
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Chlormadinone Acetate ,Endothelium ,Muscle Relaxation ,Vasodilator Agents ,Aorta, Thoracic ,Vasodilation ,Muscle, Smooth, Vascular ,General Biochemistry, Genetics and Molecular Biology ,Glibenclamide ,Phenylephrine ,Chlormadinone acetate ,chemistry.chemical_compound ,Hormone Antagonists ,Internal medicine ,medicine ,Animals ,Nandrolone ,Vasoconstrictor Agents ,Rats, Wistar ,Fulvestrant ,Progesterone ,Estradiol ,Progesterone Congeners ,Voltage-dependent calcium channel ,business.industry ,Estrogen Antagonists ,Obstetrics and Gynecology ,Potassium channel ,Rats ,Endocrinology ,medicine.anatomical_structure ,Verapamil ,chemistry ,Endothelium, Vascular ,Norethindrone ,business ,Muscle Contraction ,medicine.drug - Abstract
To compare the acute effects of progesterone, chlormadinone acetate (CMA), norethisterone acetate (NETA) and dienogest (DNG) with those of 17 beta-estradiol (17 beta-E2) on the vascular reactivity of male rat thoracic aorta.Aortic rings with or without endothelium were placed in an organ bath for isometric tension recording. The integrity of the endothelium was assessed by the relaxant response of precontracted rings to acetylcholine (1 and 10 microM), which was diminished after mechanical removal of the endothelium. The concentrations of the steroid hormones were 0.01-10 microM.In vessels precontracted with phenylephrine (1 microM), CaCl2 (3 mM) or KCl (30 mM), progesterone, CMA and NETA (10 microM each) an endothelium-independent relaxation of 20-35% resulted, with a maximum response after 20-30 min, while DNG had a negligible effect in all experiments. The same concentration of 17 beta-E2 was twice as potent as the progestins. Indomethacin, the cyclooxygenase inhibitor and glibenclamide, an inhibitor of the ATP-sensitive potassium channels, did not affect the relaxant responses. The antagonists of progesterone receptors J 867 (1 microM) as well as of estrogen receptors ICI 182780 (1 microM) did not counteract the relaxation induced by progesterone and 17 beta-E2, respectively. Progesterone (10 microM) did not interfere with endothelium-dependent acetylcholine-induced relaxation of precontracted aortic rings. Pretreatment of the vessels with the hormones attenuated the maximal contractile response to phenylephrine. In the presence of verapamil (1 microM) or progesterone (10 microM) or 17 beta-E2 (1 and 10 microM) the concentration-response curves for calcium-induced contractions in K(+)-depolarized vessels were shifted to the right, with suppression of the maximum response.These studies suggest that in addition to 17 beta-E2 the progestins, progesterone, CMA and NETA caused a reduction of vascular tone, probably due to blockade of voltage-dependent and/or receptor-operated calcium channels.
- Published
- 1997
21. A comparative study of two levonorgestrel-containing hormone replacement therapy regimens on efficacy and tolerability variables
- Author
-
K Schubert, T. Graser, U Bönisch, P Rößner, A Müller, and M Oettel
- Subjects
medicine.medical_specialty ,Patient Dropouts ,Time Factors ,medicine.drug_class ,Lipoproteins ,medicine.medical_treatment ,Levonorgestrel ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Cohort Studies ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Dose-Response Relationship, Drug ,Progesterone Congeners ,medicine.diagnostic_test ,business.industry ,Estrogen Replacement Therapy ,Estradiol valerate ,Obstetrics and Gynecology ,Hormone replacement therapy (menopause) ,Middle Aged ,Lipid Metabolism ,medicine.disease ,Lipids ,Postmenopause ,Menopause ,Regimen ,Endocrinology ,Tolerability ,Estrogen ,Female ,Uterine Hemorrhage ,business ,Lipid profile ,medicine.drug - Abstract
Objective: To compare the effect of two sequential hormone replacement regimens differing in the dose of levonorgestrel on climacteric symptoms, bleeding pattern and lipid metabolism in postmenopausal women. Study design: In a multicentre, randomized, double-blind, active-treatment-controlled study, 210 postmenopausal women were assessed at the end of treatment cycles 3 and 6. The high-levonorgestrel group was treated with 2 mg estradiol valerate (days 1–21) sequentially combined with 0.25 mg levonorgestrel (days 12–21). The low-levonorgestrel group received the same estrogen regimen (2 mg estradiol valerate, days 1–21), but levonorgestrel was administered sequentially in a dose of 0.15 mg during the last 12 days of the cycle (days 10–21). Statistical analysis by Student's t-test for dependent variables (measured values versus baseline) and independent variables (differences between groups), and the composite t-test method for comparison of both regimens with respect to efficacy, was performed. Results: Both groups were statistically comparable. The trial was completed by 137 subjects. Protocol violations occurred in 38 cases. Thirty-five subjects dropped out during the study, 21 of them because of adverse events. Both treatments were equally effective in the treatment of climacteric complaints. There were no clinically significant changes in body weight, blood pressure, haematological tests, and parameters of clinical chemistry. There was a tendency towards a reduction in bleeding intensity in both groups in the second half of the treatment period. The treatment for six cycles with both regimens significantly (P
- Published
- 1997
22. Measurements of Urinary Prostaglandins in Young Ovulatory Women During the Menstrual Cycle and in Postmenopausal Women
- Author
-
N Nassr, M. Oettel, R Vollandt, H Schweer, K Farker, A Hoffmann, Nagel U, and Hannsjörg W. Seyberth
- Subjects
Adult ,Ovulation ,medicine.medical_specialty ,Adolescent ,media_common.quotation_subject ,Prostaglandin ,6-Ketoprostaglandin F1 alpha ,Luteal Phase ,Luteal phase ,Biochemistry ,Dinoprostone ,Excretion ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,Follicular phase ,medicine ,Humans ,Menstrual Cycle ,Menstrual cycle ,media_common ,business.industry ,Middle Aged ,medicine.disease ,Postmenopause ,Thromboxane B2 ,Menopause ,Follicular Phase ,chemistry ,Prostaglandins ,Female ,lipids (amino acids, peptides, and proteins) ,business ,Hormone - Abstract
The purpose of the present work was to study the prostaglandin excretion in young nonpregnant ovulatory women during the menstrual cycle on the one hand and in postmenopausal women on the other hand and to investigate the influence of female sex hormones (estradiol, progesterone) on urinary prostanoid excretion. Urinary excretion rates of prostaglandin E2 (PGE2), 6-keto-PGF1 alpha, thromboxane B2 (TxB2) and their metabolites PGE-M (11 alpha-hydroxy-9, 15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid), 2,3-dinor-6-keto-PGF1 alpha, 2,3-dinor-TxB2 and 11-dehydro-TxB2 were determined by gas chromatography-triple stage quadrupole mass spectrometry (GC/MS/MS) in 41 young non-pregnant women during the follicular phase and during the luteal phase and in 23 postmenopausal women. Excretion rates of all urinary prostanoids were not significantly different in the follicular phase when compared with the luteal phase. In contrast to the young ovulatory women, PGE2 and TxB2 were significantly higher in postmenopausal women. Concerning the other prostaglandins significant differences between these groups of women did not exist. Although serum levels of estradiol and progesterone were different in young and postmenopausal women, sex hormones have not been shown to correlate with prostaglandins. Our data do not suggest sex hormones to be responsible for the difference in the prostaglandin excretion in women of reproductive age and in women in the menopause. Further systematic investigations into age dependency of prostaglandin excretion in women are necessary.
- Published
- 1997
23. ChemInform Abstract: Steroid Research
- Author
-
C. HOERHOLD, K. PONSOLD, G. HOBE, P. ATRAT, B. SCHOENECKER, and M. OETTEL
- Subjects
General Medicine - Published
- 2010
24. Comparison of a new long-acting testosterone undecanoate formulation vs testosterone enanthate for intramuscular androgen therapy in male hypogonadism
- Author
-
F. Jockenhövel, M. Schubert, S. Freude, T Minnemann, M Oettel, C. Schumann, Doris Hübler, Michael Ernst, I. Gouni-Berthold, A Christoph, W. Krone, and U Mellinger
- Subjects
Adult ,Leptin ,Male ,medicine.medical_specialty ,Adolescent ,Endocrinology, Diabetes and Metabolism ,Chemistry, Pharmaceutical ,Hematocrit ,Injections, Intramuscular ,law.invention ,Body Mass Index ,Grip strength ,Young Adult ,Endocrinology ,Waist–hip ratio ,Randomized controlled trial ,Pharmacokinetics ,law ,Internal medicine ,medicine ,Humans ,Testosterone ,Aged ,medicine.diagnostic_test ,Hand Strength ,business.industry ,Waist-Hip Ratio ,Hypogonadism ,Middle Aged ,Lipids ,Androgen Therapy ,Delayed-Action Preparations ,Hemoglobin ,business ,Body mass index - Abstract
Objective: To assess the efficacy and safety of a novel long-acting im testosterone undecanoate (TU) formulation in comparison with testosterone enanthate (TE). Subjects and methods: An open-label, randomized, prospective clinical trial in 40 hypogonadal men (baseline serum testosterone levels
- Published
- 2008
25. A four-year efficacy and safety study of the long-acting parenteral testosterone undecanoate
- Author
-
T. Minnemann, M. Schubert, D. Hübler, I. Gouni-Berthold, S. Freude, C. Schumann, M. Oettel, M. Ernst, U. Mellinger, F. Sommer, W. Krone, and F. Jockenhövel
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Sex hormone-binding globulin ,Prostate ,Internal medicine ,Germany ,medicine ,Humans ,Infusions, Parenteral ,Testosterone ,Aged ,Bone mineral ,medicine.diagnostic_test ,biology ,business.industry ,Leptin ,Hypogonadism ,Middle Aged ,Long acting ,Endocrinology ,Blood pressure ,medicine.anatomical_structure ,Treatment Outcome ,biology.protein ,Geriatrics and Gerontology ,Safety ,Liver function tests ,business - Abstract
This is a four-year follow-up of 25 men who received parenteral testosterone undecanoate (TU), 1000 mg every 12 weeks for at least four years. This study was a continuation of a 30-week study wherein the effects of TU had been compared to those of parenteral testosterone enanthate.Plasma testosterone (T) trough values of the injection interval of 12 weeks): median 11.9 - 15.9 nmol/L (N 10.0-30.0). E2 and SHBG were stable. Body weight, BMI, waist-to-hip ratio remained stable. Total cholesterol, and triglycerides were unchanged but plasma LDL declined while HDL, after an initial reduction over the first 30 weeks, had increased significantly after three years. Leptin levels, bone mineral density, blood pressure, liver function tests, haemoglobin and haematocrit levels remained stable without values above the upper limit of normal. Over the first 12 months of the study there was an increase in prostate volume from 19.7 +/- 8.8 mL to 22.0 +/- 8.4 mL (p0.05) but thereafter volumes remained stable, paralleled by an increase in PSA from 0.67 +/- 0.38 microg/dL to 0.75 +/- 0.35 microg/dL (p0.05) without any further changes after 12 months.TU appears to be a stable and safe treatment modality of hypogonadal men.
- Published
- 2007
26. Is there a role for estrogens in the maintenance of men's health?
- Author
-
M, Oettel
- Subjects
Male ,Aging ,Sexual Dysfunction, Physiological ,Health Status ,Humans ,Estrogens ,Aged - Abstract
This paper gives an overview of our own studies and the literature on the biosynthesis and metabolism of estrogens in elderly men, the estrogen action in the male, and the clinical usefulness of estrogen therapy, including the phytoestrogens. Finally, the paper includes a short review of our knowledge of xenoestrogens and men's sexual health. A strong estrogen-deficient status is seen in male patients with mutations of the estrogen receptors or in cases of deviations of the aromatase gene. On the other hand, there are no clear age-dependent changes in estrogen secretion. But, in men with disorders of glucose metabolism and also of increased body mass index, the serum estrogen concentrations are significantly elevated. There are also strong positive correlations between serum estrogen levels and bone density, including prevalence of fractures and mood in men. New fields of interest are natural fatty esters of endogenous estrogens, e.g. lipoprotein-associated estrogens, and the role and clinical significance of tissue-specific, local estrogen biosynthesis (e.g. different promoters of the aromatase gene). Exogenous estrogen treatment is focused today on patients with normal testosterone and low levels of circulating estrogens documented on several occasions and with clinical symptoms of hormone deficiency; male-to-female transsexuals; and selected patients with prostate cancer. Some clinical studies show the benefits of estrogen treatment on some cardiovascular parameters and for treating selected signs of mental stress. An indirect estrogen replacement can occur if dehydroepiandrosterone is given orally to men. The clinical usefulness of dissociated estrogens, including non-feminizing estrogens and selective estrogen receptor modulators, is still an open question. The beneficial action of phytoestrogens in lowering the clinical symptoms of benign prostatic hyperplasia is well documented. Finally, the question about the definitive influence of so-called endocrine disruptors (xenoestrogens) on sexual functions in men is also discussed.
- Published
- 2003
27. Hormonal contraception: what is new?
- Author
-
A. Vople, D. T. Baird, C. La Vecchia, S. Skouby, T. Farley, P. G. Crosignani, D. R. Mishell, E. Arisi, M. Bygdeman, M. Oettel, E. Diczfalusy, J. Collins, Anna Glasier, K. Schmidt-Gollwitzer, G. C. Frigerio, and F. H.Y. Wu
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Contraceptives, Oral, Hormonal ,Ovarian function ,Pregnancy ,medicine ,Humans ,Emergency contraception ,Intensive care medicine ,Adverse effect ,Population Growth ,Gynecology ,business.industry ,Patient Selection ,Combined oral contraceptives ,Contraceptive Agents, Male ,Obstetrics and Gynecology ,World population ,Contraceptive use ,Reproductive Medicine ,Hormonal contraception ,Legal abortion ,Female ,Emergencies ,business - Abstract
Hormonal contraception has become more effective and more widely used, while the world population has grown from 3000 million in 1960 to 6000 million in 2000. There is a need for improved contraception, because legal abortion is used in a high proportion of pregnancies and illegal abortion continues to be common in some countries. Hormonal contraception now includes different choices of administration and dose regimens. The best selection depends on the benefits and risks of the method and whether there is a medical disability. Medical eligibility for combined oral contraceptives has improved during the past 40 years so that, for most women, all currently available low-dose products are safe. For women with medical conditions, wider eligibility for oral contraceptive use has evolved from better knowledge of the risk factors. The long-term risks of rare cardiovascular and malignant adverse events remain controversial. There are long-term benefits, however, as oral contraceptive use appears to protect against endometrial, ovarian and colorectal cancers. Emergency contraception provides an option that reduces the number of unplanned pregnancies with little or no long-term risk. Endometrial contraception is an option that would ideally have no influence on ovarian function or the bleeding pattern, and cause no significant side-effects. Hormonal male contraception, with indirect suppression of spermatogenesis by decreasing gonadotrophin output, is a further choice. Although hormonal contraception is effective and safe, many research investigations remain to be carried out in order to improve tolerance and achieve wider utilization.
- Published
- 2002
28. Comparison of the efficacy and endometrial safety of two estradiol valerate/dienogest combinations and Kliogest for continuous combined hormone replacement therapy in postmenopausal women
- Author
-
T. Graser, M. Oettel, R. Koytchev, and A Müller
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Biopsy ,Urology ,Endometrium ,chemistry.chemical_compound ,Breast Diseases ,Double-Blind Method ,medicine ,Humans ,Nandrolone ,Vaginal bleeding ,Prospective Studies ,Gynecology ,Postmenopausal women ,Estradiol ,business.industry ,Estriol ,Estrogen Replacement Therapy ,Estradiol valerate ,Obstetrics and Gynecology ,Hormone replacement therapy (menopause) ,General Medicine ,Norethisterone acetate ,Postmenopause ,Drug Combinations ,medicine.anatomical_structure ,Treatment Outcome ,Dienogest ,chemistry ,Therapeutic Equivalency ,Endometrial Hyperplasia ,Female ,Uterine Hemorrhage ,medicine.symptom ,Norethindrone ,business ,medicine.drug - Abstract
To compare the efficacy and endometrial safety of two estradiol valerate/dienogest combinations with Kliogest in the treatment of postmenopausal symptoms.This was a double-blind, randomized, multicenter study.Patients were randomized to estradiol valerate 2.0 mg/dienogest 2.0 mg (Climodien), estradiol valerate 2.0 mg/dienogest 3.0 mg (E2Val 2/DNG 3); or estradiol 2.0 mg/estriol 1.0 mg/norethisterone acetate 1.0 mg (Kliogest) once daily for 1 year. The primary efficacy variable was the Kupperman index. Endometrial safety was determined primarily by biopsy.Climodien and E2Val 2/DNG 3 were therapeutically equivalent to Kliogest (mean changes in Kupperman index -20.1, -19.0 and -18.3, respectively). No statistically significant differences existed between treatment groups in the severity of postmenopausal symptoms. The incidences of endometrial atrophy were similar in all groups. Climodien appeared to be superior to Kliogest in terms of vaginal bleeding pattern, whereas E2Val 2/DNG 3 was associated with a slightly higher incidence and greater intensity of vaginal bleeding. The incidences of adverse events were similar in all groups. A greater proportion of women in the Kliogest and E2Val 2/DNG 3 groups experienced vaginal bleeding, whereas breast problems were more common with Climodien. Climodien and E2Val 2/DNG 3 induced desirable changes in insulin-like growth factor I (decrease) and sex hormone binding globulin (increase) that were not seen with Kliogest.
- Published
- 2002
29. The effects of postmenopausal hormone replacement therapy and oral contraceptives on the endogenous estradiol metabolism
- Author
-
Harald Seeger, Theodor H. Lippert, Alfred O. Mueck, Gräser T, and M Oettel
- Subjects
Adult ,medicine.medical_specialty ,Hydroxyestrones ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,media_common.quotation_subject ,medicine.medical_treatment ,Clinical Biochemistry ,Population ,Ethinyl Estradiol ,Biochemistry ,chemistry.chemical_compound ,Endocrinology ,Internal medicine ,Ethinylestradiol ,medicine ,Humans ,Nandrolone ,education ,Menstrual cycle ,media_common ,education.field_of_study ,Estradiol ,business.industry ,Biochemistry (medical) ,Estrogen Replacement Therapy ,Estradiol valerate ,Hormone replacement therapy (menopause) ,General Medicine ,Middle Aged ,Norethisterone acetate ,Estrogens, Catechol ,Postmenopause ,Norethindrone Acetate ,Dienogest ,chemistry ,Female ,Norethindrone ,business ,Progestin ,medicine.drug ,Contraceptives, Oral - Abstract
The estradiol metabolism may be of clinical relevance in the pathophysiology of various diseases; the increase In D-ring metabolites over A-ring metabolites in breast cancer patients is of special interest. Since estrogen therapy has been blamed for increasing the risk of breast cancer the effects of hormonal replacement therapy (HRT) and oral contraception were investigated on the ratio of the main D-ring metabolite 16alpha-hydroxy-estrone (16-OHE1) to the main A-ring metabolite 2-hydroxyestrone (2-OHE1). In our study hormone replacement therapy (HRT) in postmenopausal women consisted of administration of estradiol valerate either with or without addition of the progestin dienogest. In the second part of the study women of reproductive age received ethinylestradiol plus dienogest or ethinylestradiol plus norethisterone acetate as oral contraceptives (OC). 2-OHE1 and 16-OHE1 were measured by enzyme immunoassay in 8 hour night-urine collected before and after 3 months of hormone administration. With HRT that is estradiol valerate or estradiol valerate plus dienogest the ratios before treatment were 0.47 and 0.60; after 3 months they were 0.54 and 0.52 respectively. There were no significant differences. With oral contraception that is ethinylestradiol plus dienogest or norethisterone acetate the ratios before administration were 0.62 and 0.68 vs. 0.31 and 0.54 after 3 months respectively. The ratio after ethinylestradiol and dienogest was significantly lower after treatment. HRT and OC in the estrogen-progestin combinations tested did not impose any negative effects on estradiol metabolism-- they did not elicit a higher D-ring metabolism which is considered to increase breast cancer risk. (authors)
- Published
- 2001
30. Antiatherogenic effects of 17 beta-estradiol and 17 alpha-estradiol and its derivative J811 in cholesterol-fed rabbits with thyroid inhibition
- Author
-
V U, Buko, O, Lukivskaya, E, Naruta, Y, Popov, A, Chirkin, I, Chirkina, M, Oettel, W, Römer, and D, Hübler
- Subjects
Male ,Sex Characteristics ,Dose-Response Relationship, Drug ,Estradiol ,Arteriosclerosis ,Anticholesteremic Agents ,Cholesterol, HDL ,Hypercholesterolemia ,Drug Evaluation, Preclinical ,Free Radical Scavengers ,Thiouracil ,Disease Models, Animal ,Random Allocation ,Antithyroid Agents ,Animals ,Diet, Atherogenic ,Rabbits - Abstract
The aim of this study was to investigate the antiatherogenic effects of 17 beta-estradiol and 17 alpha-estradiol and its derivative J811 (estra-1,3,5(10),8-tetraene-3, 17 alpha-diol), having a non-feminizing effect and high antioxidant potential, in male rabbits.Male White-Russian rabbits weighing 2.1-2.6 kg were fed either a standard or a high-cholesterol (200 mg/kg) diet, with thyroid function-inhibiting thiouracil (20 mg/kg) combined with cholic acid (40 mg/kg) administered daily in sunflower oil for 3 months. During the last month of the study, estrogens were administered by gavage at a dose of 0.02 or 0.1 mg/kg.All three estrogens exerted remarkable antiatherosclerotic effects. Decreases in serum and aortic-wall lipid parameters and the index of atherogenicity were dependent on estrogen dose. Morphological evaluation of the aortic wall (height of plaques, size of plaque relative to aortic half-circumference) showed only weak therapeutic effects with all three estrogens. It is an open question whether the treatment period was too short to reverse the above changes. On the other hand, the data clearly suggest that 17 alpha-estradiol and J811 offer new perspectives for the prevention of atherosclerosis in men, which is similar to that found with 17 beta-estradiol in women.
- Published
- 2001
31. Calcium antagonistic effect of 17 alpha-estradiol derivatives: in vitro examinations
- Author
-
M Oettel, Alfred O. Mueck, S. Schwarz, Harald Seeger, and Theodor H. Lippert
- Subjects
medicine.medical_specialty ,Estradiol ,Endocrinology, Diabetes and Metabolism ,Calcium Radioisotopes ,Obstetrics and Gynecology ,chemistry.chemical_element ,Muscle, Smooth ,Free Radical Scavengers ,Calcium ,Ethinyl Estradiol ,17 beta estradiol ,In vitro ,Antioxidants ,Endocrinology ,chemistry ,Smooth muscle ,Internal medicine ,medicine ,Humans ,Calcium influx ,hormones, hormone substitutes, and hormone antagonists ,Aorta - Abstract
The calcium antagonistic effect of 17 alpha-estradiol derivatives was investigated in vitro in human aortic smooth muscle cells. The substances tested were 17 alpha-estradiol, 17 alpha-ethinylestradiol, the scavestrogens J811 and J861, and 17 beta-estradiol. Examinations were carried out by measuring 45Ca influx into the cells. All compounds showed a significant inhibition of calcium influx at the concentration of 10(-6) M. The strongest effect could be registered for the scavestrogens. Since these substances are virtually devoid of estrogenic activity, they may offer advantages over 17 beta-estradiol in the therapy and prevention of cardiovascular disease.
- Published
- 1999
32. Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells
- Author
-
M E, Götz, E, Ahlbom, B, Zhivotovsky, D, Blum-Degen, M, Oettel, W, Römer, P, Riederer, S, Orrenius, and S, Ceccatelli
- Subjects
Cell Nucleus ,Neurons ,Time Factors ,Dose-Response Relationship, Drug ,Estradiol ,Estrogen Antagonists ,Apoptosis ,DNA Fragmentation ,Free Radical Scavengers ,Hydrogen Peroxide ,Antioxidants ,Rats ,Rats, Sprague-Dawley ,Oxidative Stress ,Cerebellum ,Animals ,Colchicine ,Fulvestrant ,Cells, Cultured - Abstract
Oxidative stress is considered to be an important pathophysiological condition to promote cell death in a broad variety of disorders, such as cardiovascular and neurodegenerative diseases. Scavestrogens, structurally derived from estradiol, are potent radical scavengers and inhibitors of iron-induced cell damage in vitro. In this study the potential cytoprotective effects of the so-called scavestrogen estra-1,3,5(10),8-tetraene-3,17alpha-diol, J 811, was tested using rat cerebellar granule cells (CGCs) exposed to 25 or 50 microM hydrogen peroxide (H2O2). H2O2-induced apoptotic cell death was detected by the appearance of high molecular weight DNA fragments and nuclear condensation. The addition of J 811 before or shortly after the exposure to H2O2 prevented CGC apoptosis in a dose-dependent manner. The estrogen receptor antagonist ICI 182.780 failed to prevent the protective effect of J 811, suggesting that the latter is not dependent on estrogen receptor activation. The lack of protection against apoptosis caused by colchicine suggests that J 811 is neither interfering with the activation of caspase-3, nor acting downstream of caspase-3. Therefore, the protective effect observed against H2O2 seems to be upstream caspases activation, pointing to a scavenging action of J 811. Thus the scavestrogen J 811 is a powerful antioxidant able to interfere with radical-mediated cell death and is potentially useful in diseases where reactive oxygen species are involved.
- Published
- 1999
33. Intramuscular injection of testosterone undecanoate for the treatment of male hypogonadism: phase I studies
- Author
-
M Oettel, K. Abshagen, Eberhard Nieschlag, Hermann M. Behre, and D Hubler
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Blood Pressure ,Injections, Intramuscular ,Dosage form ,Endocrinology ,Internal medicine ,Sex Hormone-Binding Globulin ,Medicine ,Humans ,Testosterone ,Substitution therapy ,Gluteal muscles ,Testosterone Congeners ,Estradiol ,business.industry ,Male hypogonadism ,Hypogonadism ,Body Weight ,General Medicine ,Middle Aged ,Hormones ,medicine.anatomical_structure ,Castor oil ,Testosterone enanthate ,business ,Intramuscular injection ,Gonadotropins ,medicine.drug - Abstract
OBJECTIVE: In the search for long-acting testosterone preparations suited for substitution therapy of hypogonadal men, testosterone undecanoate (TU) dissolved in either tea seed oil or castor oil was investigated. DESIGN: In study I, 1000 mg TU in tea seed oil (125 mg/ml) were injected in equal parts into the gluteal muscles of seven hypogonadal men. In study II, 1000 mg TU in castor oil (250 mg/ml) were injected into one gluteal muscle of 14 patients. RESULTS: In comparison with published data on testosterone enanthate, most widely used for i.m. injections, the kinetic profiles of both TU preparations showed extended half-lives and serum levels not exceeding the upper limit of normal. The castor oil preparation had a longer half-life than TU in tea seed oil (33.9+/-4.9 vs 20.9+/-6.0 days (mean pm S.E.M.)). CONCLUSION: The longer half-life and the smaller injection volume make TU in castor oil a strong candidate for further applications in substitution therapy and in trials for male contraception.
- Published
- 1999
34. Can oral contraceptive steroids influence the elimination of nifedipine and its primary pryidine metabolite in humans?
- Author
-
G. Klinger, U. Mellinger, S. Gessinger, M. Hippius, U. Svarovsky, Hoffmann A, Balogh A, and M. Oettel
- Subjects
Adult ,genetic structures ,Nifedipine ,Pyridines ,Metabolite ,Population ,Levonorgestrel ,Pharmacology ,Ethinyl Estradiol ,Contraceptives, Oral, Hormonal ,Mixed Function Oxygenases ,chemistry.chemical_compound ,Cytochrome P-450 Enzyme System ,Estradiol Congeners ,Oral administration ,Ethinylestradiol ,Cytochrome P-450 CYP3A ,medicine ,Contraceptive Agents, Female ,Humans ,Nandrolone ,Pharmacology (medical) ,Drug Interactions ,education ,education.field_of_study ,CYP3A4 ,business.industry ,General Medicine ,Calcium Channel Blockers ,stomatognathic diseases ,chemistry ,Area Under Curve ,Female ,business ,medicine.drug ,Half-Life - Abstract
To investigate the influence of oral contraceptives on cytochrome P450 3A4 (P450NF) activity.In 23 healthy women, the pharmacokinetics of nifedipine and its main metabolite dehydronifedipine in plasma were assessed after a single oral dose, prior to and after intake of one of two oral contraceptive formulations, one containing 2 mg dienogest and 0.03 mg ethinylestradiol (group A) and the other containing 0.125 mg levonorgestrel and 0.03 mg ethinylestradiol (group B).While the intake of two oral contraceptives for 21 days did not influence the plasma concentration-time curve of unchanged nifedipine, mean AUC0-23.5 h and the mean Cmax values of dehydronifedipine were significantly lower in both groups tested/(24% in group A and 25% in group B). This observation may indicate a reduced formation rate of metabolites and reflects an inhibition of cytochrome P450 3A4 activity. The activation of the same or other metabolic degradation mechanism(s) could explain this result.The investigation presented demonstrates the importance of metabolite measurement when in vivo studies are undertaken to investigate different influences on drug metabolizing ability.The influence of combined oral contraceptives (OCs) on cytochrome P450 3A4 activity was investigated in a study of 23 healthy women. The pharmacokinetics of nifedipine and its main metabolite, dehydronifedipine, in plasma were measured after a single oral dose, before and after intake of 1 or 2 OC formulations. The first contained 2 mg of dienogest and 0.03 mg of ethinyl estradiol (group A); the second contained 0.125 mg of levonorgestrel and 0.03 mg of ethinyl estradiol (group B). OC use for 21 days did not influence the plasma concentration-time curve of unchanged nifedipine. However, the mean area-under-curve values at 0-23.5 hours after nifedipine administration were significantly lower than baseline (by 24% in group A and 25% in group B). This finding may indicate a reduced formation rate of metabolites and reflects an inhibition of cytochrome P450 3A4 activity. Activation of the same or other metabolic degradation mechanisms could explain this finding. Assessment of its clinical importance requires a longer period of nifedipine use. This study demonstrates the importance of metabolite measurement when in vivo studies are undertaken to investigate different influences on drug metabolizing activity.
- Published
- 1999
35. A
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
36. H
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
37. I
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
38. C
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
39. G
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
40. Estrogens and Antiestrogens in the Male
- Author
-
M. Oettel
- Subjects
medicine.medical_specialty ,17β-oestradiol ,Endocrinology ,Aromatase inhibitor ,medicine.drug_class ,Estrogen ,Internal medicine ,medicine ,Biology ,Luteinizing hormone ,Antiestrogen ,hormones, hormone substitutes, and hormone antagonists - Abstract
Estrogens and men - this is a topic which has been neglected for quite some time and it is only relatively recently that discussion of it has intensified remarkably. The discussion has not been restricted to the scientific community. In former times, the role of estrogens in male physiology received little attention since androgens clearly have a dominant role. It is now becoming more and more evident that estrogens are far more important in the male than we had supposed (HABENICHT 1998).
- Published
- 1999
41. F
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
42. B
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
43. D
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
44. K
- Author
-
Franz von Bruchhausen, Eberhard Hackenthal, Siegfried Ebel, Ulrike Holzgrabe, August Wilhelm Frahm, M. Albinus, G. Amschler, E. von Angerer, null Arras-Reiter, P. Barth, W. Barthel, K. Bauer, P. Bauer, I. Baumann, J. Beckmann, W. Beil, J. Reitz, K. Binder, F. Bossle, F. Bracher, H. Bräunlich, E. Bretschneider, R. Brigelius-Flohé, K. Brinkmann, F. von Bruchhausen, A. Rüge, W. Christ, M. Cimbollek, R. Daniels, G. Dannhardt, H. Duchstein, S. Ebel, K. Eger, P. Eichhorn, U. Eiben, T. Erker, P. Felfe, A. Frahm, M. Frahm, V. Franke, K. Freundt, D. Geffken, U. Geis, E. Glusa, B. Göber, P. Gobina, W. Golder, M. GoppeltStrübe, K. Götte, E. Gottstein, G. Greif, A. Grisk, M. Grosam, H. Gustmann, M. Gütschow, E. Hackenthal, A. Häfner, B. Haluszczynski, A. Harder, H. Häusler, D. Heber, M. Heidenreich, G. Heinemeyer, E. Heller, D. von Herrath, J. Hilfenhaus, H. Hoffmann, U. Hoffmann-Schollmayer, B. Hofmann, C. Holpert, U. Holzgrabe, U. Hübner-Steiner, M. Hug, E. Inkmann, A. Jördens, J. Jürgens, B. Kaiser, D. Kalbhen, H. Kemmler, P. Kisser, D. Kleinsorge, C. Klett, S. Klett, M. Klingmüller, H. Klöcking, A. Kramer, B. Krammer, M. Kreher, M. Krüger, M. Kuhn, D. Landsiedel-Maier, P. Lauven, J. Lehmann, M. Lehner, D. Leopoldt, A. Maurer, W. Meindl, K. Menges, P. Messinger, F. Meyer, W. Meyerhof, R. Morgenstern, U. Mühlhans, A. Müller, C. Müller, K. Müller, A. Mülsch, C. Nachtsheim, M. Neugebauer, W. Neupert, P. Nickel, P. Nuhn, B. Nürnberg, H. Oelschläger, J. Oertel, M. Oettel, R. Ott, T. Ott, T. Otzen, P. Pachaly, H. Pelzer, K. Petersen, R. Pick, M. Pickert, A. Pies, H. Priewer, O. Queckenberg, G. Radau, E. Reimann, J. Remien, M. Reuß, W. Reuß, J. Richter, P. Richter, K. Riecke, H. Rommelspacher, U. Rose, G. Roth, D. Rothley, G. Rücker, J. Schäfer, J. Schantl, H. Schlager, H. Schleinitz, W. Schlichter, M. Schmauß, H. Schmidhammer, G. Schmidt, T. Schmidt, H. Schmitt, J. Sehräder, T. Schulz, H. Schwilden, M. Serke, G. Skopp, G. Skorka, K. Smolinka, U. Speck, M. Spohn, R. Stahlmann, J. Stasch, C. Steffen, H. Stein, J. Steinmeyer, K. Stiefvater, G. Strippel, K. Surborg, U. Stürig, H. Szelényi, I. Szelényi, A. Täufel, R. Thieroff-Ekerdt, R. Troschütz, H. Ungeheuer, B. Unterhalt, E. Verspohl, S. Vogel, F. Volk, T. Vorwerk, J. Wallmann, H. Weber, M. Wenzel, M. Weyandt-Spangenberg, S. Wich, R. Wintersteiger, B. Wüst, and D. Youssef
- Published
- 1999
45. Approaches to the replacement of ethinylestradiol by natural 17beta-estradiol in combined oral contraceptives
- Author
-
C. Moore, T. Graser, H. Hoffmann, M. Oettel, Walter Elger, H. Zimmermann, and Sigfrid Prof-Dr Schwarz
- Subjects
medicine.drug_class ,Pharmacology ,Toxicology ,Ethinyl Estradiol ,Drug Administration Schedule ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,Estradiol Congeners ,Ovarian Follicle ,Oral administration ,Ethinylestradiol ,medicine ,Animals ,Humans ,Menstrual Cycle ,Clinical Trials as Topic ,Estradiol ,business.industry ,Combined oral contraceptives ,Cell Biology ,General Medicine ,Rats ,Contraceptives, Oral, Combined ,Dienogest ,chemistry ,Estrogen ,Concomitant ,Toxicity ,Female ,business ,Progestin ,medicine.drug - Abstract
Summary The strong hepatic estrogenic actions of ethinylestradiol (EE) are very likely to be the cause of the cardiovascular morbidity related to the use of combined oral contraceptives (COCs). This survey presents results of EE replacement inCOCs with natural 17β-estradiol (E2) in the following stages: reduction of EE to daily doses of 0.01 mg and concomitant replacement with E2 (as valerate, EV), complete replacement of EE with E2 using a novel multiphasic combination containing EV and the progestin dienogest (DNG), and the use of natural E2 to develop estrogen sulfamates (J 995) showing sufficient dissociation of uterine from liver estrogenicity. Recent data from preclinical and clinical studies show that these approaches seem to be promising.
- Published
- 1998
46. Scavestrogens protect IMR 32 cells from oxidative stress-induced cell death
- Author
-
D. Blum-Degen, R. Harth, W. Römer, M. Haas, Peter Riederer, S. Pohli, M. Oettel, and M.E. Götz
- Subjects
Programmed cell death ,Cell Survival ,Iron ,Cell ,Oxidative phosphorylation ,Pharmacology ,Toxicology ,medicine.disease_cause ,Thiobarbituric Acid Reactive Substances ,Antioxidants ,chemistry.chemical_compound ,Neuroblastoma ,medicine ,Tumor Cells, Cultured ,Humans ,Viability assay ,Cell damage ,chemistry.chemical_classification ,Reactive oxygen species ,Cell Death ,Estradiol ,Chemistry ,Glutathione ,Free Radical Scavengers ,Hydrogen Peroxide ,medicine.disease ,Oxidative Stress ,medicine.anatomical_structure ,Biochemistry ,Lipid Peroxidation ,Oxidative stress - Abstract
Oxidative stress is considered an important pathophysiological mechanism contributing to promote cell death in a broad variety of diseases including cardiovascular and neurodegenerative disorders. The so-called scavestrogens J811 and J861, structurally derived from 17alpha-estradiol, are potent radical scavengers and inhibitors of iron-induced cell damage in vitro. In this study the potential cytoprotective effects of the scavestrogens J811 and J861 against Fenton reagent-induced cell damage (50 microM FeSO4 plus 200 microM H2O2) were compared with those of 17alpha- and 17beta-estradiol. Cell viability studies using Trypan blue staining showed that estradiols and scavestrogens at concentrations ranging from 0.1 to 10 microM are able to protect IMR 32 neuroblastoma cells from Fenton-mediated death. In addition, these compounds decreased lipid peroxidation measured as thiobarbituric acid reactive substances and renormalize oxidative stress-increased intracellular glutathione levels. When given 6 h after the toxic stimulus, J811 and J861 rescued 60% of cells, whereas 17alpha- and 17beta-estradiol were ineffective. These results suggest that the scavestrogens J811 and J861 are powerful antioxidants capable of interfering with radical-mediated cell death in diseases known to be aggravated by reactive oxygen species. Such compounds may be useful in the development of novel treatments for stroke or neurodegenerative disorders.
- Published
- 1998
47. Evaluation of an oral pulsatile delivery system for melatonin in humans
- Author
-
H, Hoffmann, M, Dittgen, A, Hoffmann, C, Bartsch, H, Breitbarth, C, Timpe, K, Farker, U, Schmidt, U, Mellinger, H, Zimmermann, T, Gräser, and M, Oettel
- Subjects
Adult ,Male ,Cross-Over Studies ,Drug Delivery Systems ,Area Under Curve ,Delayed-Action Preparations ,Humans ,Half-Life ,Melatonin - Abstract
Using melatonin (MT) as a circadian synchroniser in humans to treat a variety of rhythm disorders, it is desirable to develop controlled-release dosage forms that deliver MT in accordance with its endogenous secretory pattern as well as preparations that release MT in a pulsatile way. In this paper we describe two oral pulsatile dosage forms containing 10 mg MT each (capsules B and C) and a fast-release form containing 5 mg MT (capsule A) studied in a randomised single-dose, threefold cross-over study in 15 healthy male volunteers. The concentrations of both MT in serum and its main metabolite 6-sulfatoxymelatonin (aMT6s) in urine were analysed by means of specific radioimmunoassays up to 10 h p.a. of the MT preparations. Mean peak concentrations of MT in serum were reached between 0.5 h and 0.75 h (Cmax[1] pmol/ml): 20.7 (A), 16.4 (B), 9.7 (C). The capsules B and C released a second MT pulse after about 3.5 h with Cmax[2] of 13.0 and 17.5 pmol/ml, respectively. Dose proportionality for the MT preparations studied was calculated by determining the AUC0-infinity (pmol/ml.h): 18.4 (A), 36.1 (B), 42.4 (C). The terminal serum half-lives of MT ranged between 0.64 and 0.84 h. The time course of the renally excreted aMT6s correlated with that of changes in MT serum concentrations.
- Published
- 1998
48. Influence of hormonal contraceptives on microbial flora of gingival sulcus
- Author
-
W. Pfister, G. Klinger, C. Moore, M. Oettel, Thomas Gräser, and S. Eick
- Subjects
Adult ,medicine.drug_class ,Gingiva ,Dentistry ,Physiology ,Ethinyl Estradiol ,Aggregatibacter actinomycetemcomitans ,Prevotella intermedia ,Contraceptives, Oral, Hormonal ,chemistry.chemical_compound ,Gingivitis ,stomatognathic system ,Desogestrel ,Ethinylestradiol ,medicine ,Humans ,Nandrolone ,Gingival sulcus ,biology ,business.industry ,Obstetrics and Gynecology ,biology.organism_classification ,Reproductive Medicine ,Dienogest ,chemistry ,Estrogen ,Actinobacillus ,Female ,medicine.symptom ,business ,Porphyromonas gingivalis ,medicine.drug - Abstract
To determine a possible influence of two different hormonal contraceptives on bacterial microflora of gingival sulcus, subgingival plaque samples of 29 healthy women aged between 20 and 32 years were investigated bacteriologically before subjects took a contraceptive and 10 and 20 days after subjects started the medication. In 14 women, and oral contraceptive containing 0.02 mg ethinyl estradiol and 0.15 mg desogestrel (preparation A) was used, and 15 women took a contraceptive containing 0.03 mg ethinyl estradiol and 2.00 mg dienogest (preparation B) daily over 21 days. There were no changes in clinical parameters of the teeth investigated during 3 weeks of the study. The periodontopathogenic bacteria Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were never detected throughout the study. On the other hand, the periodontopathogenic species Prevotella intermedia was found in plaque samples of 22 women. The content of this microorganism showed only a little change between the pretreatment period and plaque sampling after 10 days of contraceptive treatment, but a striking increase occurred after 20 days of contraceptive treatment, especially in the preparation A group. In this respect, there was a significant difference between preparations A and B.Several studies have suggested an association between sex hormones and chronic inflammatory periodontal disease. This study investigated the impact of two oral contraceptives (OCs) on bacterial microflora of gingival sulcus samples obtained from 29 women 20-32 years of age recruited from Jena (Germany) University Women's Hospital. Study participants were randomly assigned to receive an OC containing either 0.02 mg of ethinyl estradiol and 0.15 mg of desogestrel (n = 14) or 0.03 mg of ethinyl estradiol and 2.00 mg of dienogest (n = 15). Subgingival plaque samples were obtained before and 10 and 20 days after the initiation of OC use. No changes in clinical parameters of the upper incisors (i.e., bleeding on probing, pocket depth, plaque) occurred in either study group during 21 days of OC use. Although Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were not detected, 22 plaque samples showed evidence of the periodontopathogenic bacteria Prevotella intermedia. The mean cultivable content of this microorganism increased significantly in users of the OC containing desogestrel from 1.2% at day 10 of OC use to 10.0% at day 20, but decreased slightly in women assigned to the OC containing dienogest and a higher dose of ethinyl estradiol. Good oral hygiene is essential in pregnancy and during OC use to compensate for hormonal influences and prevent gingivitis.
- Published
- 1998
49. Are the antioxidative effects of 17 beta-estradiol modified by concomitant administration of a progestin?
- Author
-
M. Dören, J. Schröder, B. Schneider, and M. Oettel
- Subjects
endocrine system ,medicine.medical_specialty ,medicine.drug_class ,Estrone ,Levonorgestrel ,Pharmacology ,In Vitro Techniques ,Valerate ,General Biochemistry, Genetics and Molecular Biology ,Drug Administration Schedule ,chemistry.chemical_compound ,Oral administration ,Internal medicine ,medicine ,Animals ,Humans ,Climacteric ,chemistry.chemical_classification ,Dose-Response Relationship, Drug ,Estradiol ,business.industry ,Estrogen Replacement Therapy ,Estradiol valerate ,Obstetrics and Gynecology ,Middle Aged ,Lipoproteins, LDL ,Endocrinology ,chemistry ,Estrogen ,Ovariectomized rat ,Drug Therapy, Combination ,Female ,Lipid Peroxidation ,Rabbits ,Progestins ,business ,Progestin ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Objective : Estrogens are known to exhibit antioxidative effects. At present little information exists on the influence of co-administered progestins upon this effect. Therefore we investigated the influence of levonorgestrel, a potent antiestrogenic progestin, on the inhibition of the low-density lipoprotein (LDL) oxidation by 17β-estradiol or 17β-estradiol valerate in vitro and ex vivo. Methods : After isolation from blood, the in vitro oxidation of LDL was induced by copper ions and measured continuously by monitoring the formation of conjugated dienes. In 21 female ovariectomized White New Zealand rabbits the antioxidative action of 17β-estradiol alone or in combination with levonorgestrel after subcutaneous infusion for 3 days was determined using the copper-induced LDL-oxidation as an endpoint. Eleven postmenopausal women were exposed to sequential estrogen-progestin replacement therapy (day 1–21: 2 mg estradiol valerate/day, day 10–21: 0.15 mg levonorgestrel/day). Blood samples were collected at three times: on day 1, on day 10, on day 22 (after the combination phase). The lag time of ex vivo oxidation of LDL, the plasma estradiol and estrone levels were estimated. Results : In the chosen cell-free system, 17β-estradiol increased the lag time of the LDL-oxidation in a dose-dependent manner. Levonorgestrel showed neither pro-oxidative nor antioxidative effects when administered alone in different concentrations. Co-administration of different doses of levonorgestrel did not modify the antioxidative action of estrogen either. The two ex-vivo models confirmed these results. In rabbits the co-administered 19-nortestosterone derivative levonorgestrel did not impair or reverse the estradiol-dependent effect. In postmenopausal women the daily oral administration of levonorgestrel in conjunction with 17β-estradiol valerate did not diminish the antioxidative action of this estrogen given for the first 9 days. Conclusion : The antioxidative potential of estradiol and estradiol valerate is maintained in the presence of levonorgestrel.
- Published
- 1996
50. Pharmakologisch-toxikologisches Wirkprofil von Dienogest
- Author
-
M. Oettel, J. Richard, H. Hoffmann, H. G. Hillesheim, G. Sykes, E. Kuchling, and H. Zimmermann
- Published
- 1995
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