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Long Term Toxicological Studies on the Progestin STS 557
- Source :
- Experimental and Clinical Endocrinology & Diabetes. 81:179-196
- Publication Year :
- 2009
- Publisher :
- Georg Thieme Verlag KG, 2009.
-
Abstract
- The toxicity of 17 alpha-cyanomethyl-17 beta-hydroxy-estra-4, 9-dien-3-one (STS 557) was studied by its oral administration of 0.1, 1.0 or 10.0 mg/kg/day to Wistar rats for six months, and of 0.01, 0.1 or 1.0 mg/kg/day to beagle dogs for six months, respectively. Levonorgestrel at a dose of 1.0 mg/kg/day was used as the standard in the dog study. With respect to the progestational activity of the compound the main target organs were the hypophysis, the reproductive organs and the adrenals. Mammary hyperplasia was observed in dogs treated with STS 557 or levonorgestrel at the dose of 1.0 mg/kg/day, but in no case mammary nodules could be detected. At the dose of 1.0 mg/kg/day STS 557 and levonorgestrel were found to increase the plasma insulin response to i.v. glucose in bitches, but neither the mean blood glucose levels nor the glucose utilization were affected. Moreover, during administration of both steroids to dogs temporary changes in serum concentrations of triglycerides and total cholesterol were noted. The results obtained in rats and dogs from functional and morphological investigations did not reveal any toxic side effects of STS 557 on the liver, the kidneys, the bone marrow or on blood coagulation. The effects on the reproductive organs observed following STS 557 especially in dogs are related to both the hormonal effects of the compound and the specific response of the dog to potent progestagens.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Levonorgestrel
Beagle
Eating
Dogs
Endocrinology
Oral administration
Internal medicine
Internal Medicine
medicine
Animals
Nandrolone
Progesterone Congeners
business.industry
Body Weight
Norgestrel
Organ Size
General Medicine
Glucose Tolerance Test
Hyperplasia
medicine.disease
Hormones
Rats
Contraceptives, Oral, Combined
medicine.anatomical_structure
Toxicity
Female
Bone marrow
business
Progestin
medicine.drug
Hormone
Subjects
Details
- ISSN :
- 14393646 and 09477349
- Volume :
- 81
- Database :
- OpenAIRE
- Journal :
- Experimental and Clinical Endocrinology & Diabetes
- Accession number :
- edsair.doi.dedup.....a8cba0f79c39e9909552d3c671488e3e