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Laser-induced graphene (LIG) technology featuring low-cost, high-efficiency and scalability has presented great advantages in micro-supercapacitors (MSCs) fabrication. However, the limited capacitance of LIG based MSCs is still hindering their further development. Herein, we introduce joule heating as a critical in-situ treatment merged with the assembly of laser-induced graphene paper based MSCs (LIGP-MSCs) toward capacitive enhancement. By increasing heating-treatment temperature from ∼20 to 500 °C, the number of nanopores in LIGP continuously increases, attributed to the gradual decomposition of amorphous carbon components. The resulting joule-heated LIGP (J-LIGP) with improved specific surface area (160.97–533.49 m2/g) and pore volume (0.179–0.553 cm3/g) as well as superhydrophilic surface is highly suitable to be employed as J-LIGP-MSCs microelectrodes. By investigating process dependent performance, the J-LIGP-MSCs heated at 500 °C for 60 min delivers a significantly improved specific areal capacitance (CA) of 13.71 mF/cm2 at 10 mV/s, which is approximately six-fold higher than that of unheated LIGP-MSCs. By further exploring and optimizing the process efficiency, J-LIGP-MSCs with a CA of 12.61 mF/cm2 has been achieved by 550 °C heating for only 5 min. Along with superior mechanical flexibility, cyclability and structural modularity, the proposed in-situ joule heating treatment is finally proved to be a universal approach for consistently enhancing the CA of LIG based MSCs processed under various chemical modifications.

Time-limited exposure of electrode-free optically rewritable electronic paper is essential for applications, but performance characteristics can be modest. In this study we investigate whether imag...

We demonstrated the thermally robust reduced graphene oxide (rGO)/boron nitride nanotube (BNNT) papers and their application in electromagnetic interference shielding. In order to overcome the thermal durability shortcomings of electromagnetic wave shielding paper based on rGO nanomaterial, rGO/BNNT electromagnetic interference (EMI) shielding paper having excellent thermal durability could be manufactured using BNNT nanomaterials having excellent chemical and thermal stability at high temperature. With the addition of a little BNNT, the durability against temperature can be increased by more than two times while there is little reduction in EMI performance.

In this study, Taguchi experimental design was used to the optimize operating parameters for the degradation of paper mill effluent using electrochemical (EC) process with two-dimensional concentric aluminum tube electrodes (CATE). For this purpose, four significant experimental factors were used in four levels pH (6–9), electrolysis time (10–40 min), voltage (6–12 V) and surface area (357–624 cm(2)). The process parameters were optimized, through performing L16 orthogonal array of Taguchi technique, for the removal of chemical oxygen demand (COD) and turbidity. The percent COD and turbidity reductions were transferred into an accurate S/N ratio for a larger value is the better (LBT) response. The study presents a unique method of finding optimum combination of process parameters to illustrate their effect on the turbidity and COD reduction. The treatment conditions for the maximum elimination of the pollutants were second level of pH (7), third level of ET (30 min), fourth level of voltage (12 V) and second level of surface area (446 cm(2)). The confirmation experiment results were within the confidence intervals (CI) indicating an acceptable agreement between predicted and observed values. Based on the p-values, the electrolysis time and voltages were found to be the most significant factors for both COD and turbidity reduction. The findings of research indicated, that the Taguchi method can be used successfully for the treatment of paper industry effluent by electrochemical technique.

The work aims to explore a microscopic observation system of paper surface and achieve high-precision stereoscopic observation with detail characterization of paper surface morphology. Based on the DT-400E precision program-controlled three-dimensional translation stage and KEYENCE LJV-7200 two-dimensional laser scanner, the hardware parts of our own system are developed to scan and transmit point cloud data of paper surface morphology to the computer. The corresponding system software will automatically process the point cloud data acquired from the laser scanner and generate the corresponding vivid 3D model and height histogram. This system scans and characterizes four different types of paper samples, allowing the human eye to visually distinguish the differences in surface morphology as well as automatically calculate the numerical differences in paper surface morphology parameters. The results of the applicability test show that the system is highly efficient in acquiring, observing, and evaluating the topography of the paper surface. The system can not only predict the paper surface quality of printed paper, but can also be extended to the evaluation of 3D printed surfaces.

Flexible paper-based sensors may be applied in numerous fields, but this requires addressing their limitations related to poor thermal and water resistance, which results in low service life. Herein, we report a paper-based composite sensor composed of carboxylic carbon nanotubes (CCNTs) and poly-m-phenyleneisophthalamide (PMIA), fabricated by a facile papermaking process. The CCNT/PMIA composite sensor exhibits an ability to detect pressures generated by various human movements, attributed to the sensor's conductive network and the characteristic "mud-brick" microstructure. The sensor exhibits the capability to monitor human motions, such as bending of finger joints and elbow joints, speaking, blinking, and smiling, as well as temperature variations in the range of 30-90 °C. Such a capability to sensitively detect pressure can be realized at different applied frequencies, gradient sagittas, and multiple twists with a short response time (104 ms) even after being soaked in water, acid, and alkali solutions. Moreover, the sensor demonstrates excellent mechanical properties and hence can be folded up to 6000 times without failure, can bear 5 kg of load without breaking, and can be cycled 2000 times without energy loss, providing a great possibility for a long sensing life. Additionally, the composite sensor shows exceptional Joule heating performance, which can reach 242 °C in less than 15 s even when powered by a low input voltage (25 V). From the perspective of industrialization, low-cost and large-scale roll-to-roll production of the paper-based sensor can be achieved, with a formed length of thousands of meters, showing great potential for future industrial applications as a wearable smart sensor for detecting pressure and temperature, with the capability of electric heating.

Edible oils form an integral component in the human diet as well as in the industrial preparations. Any adulteration in oil is concerning from nutritional as well as economical perspective. Although analytical techniques exist for detection of adulterants in oil, most of them require sophisticated instruments, and trained professionals. Microfluidic based lab-on-a-chip technologies have rapidly progressed over the recent years and offer promising alternatives in this regard. In this work, we report development of a paper-based microfluidic lab-on-a-chip for detection of palm oil contamination in sunflower oil. We use the paper-based microfluidic colorimetric detection approach that indicates the presence of adulteration in a visual manner. The data is analyzed using digitally acquired images along with ultraviolet–visible spectrophotometry. The paper-based microfluidic device is fabricated and tested for 10–50% (v/v) palm oil adulteration in sunflower oil. Further, we employ the device for free fatty acid content tests in oil samples. Visual signal acquired from the device is optimized by varying phenolphthalein proportions. The stability of visual colorimetric signal is examined over time and is found to remain steady over the trial period of six days considered in this work. The integration of the detection device with smartphone imaging can prove to be useful for onsite data collection. We believe the approach presented here can be extended to food quality monitoring portable platforms.

Organic electrochemical transistors (OECTs) have attracted great interest in the last few years as biochemical sensors due to their outstanding analytical performance, versatility, stability, and e...

This collaborative statement from the Digital Health Committee of the Heart Rhythm Society provides everyday clinical scenarios in which wearables may be utilized by patients for cardiovascular health and arrhythmia management. We describe herein the spectrum of wearables that are commercially available for patients, and their benefits, shortcomings and areas for technological improvement. Although wearables for rhythm diagnosis and management have not been examined in large randomized clinical trials, undoubtedly the usage of wearables has quickly escalated in clinical practice. This document is the first of a planned series in which we will update information on wearables as they are revised and released to consumers.

This is a pre-copyedited, author-produced version of an article accepted for publication in European Journal of Preventive Cardiology following peer review. The version of record Kavousi, Pisinger, Barthelemy, Smedt, Koskinas, Marques-Vidal, Panagiotakos, Prescott, Tiberi, Vassiliou, Løchen. Electronic cigarettes and health with special focus on cardiovascular effects: position paper of the European Association of Preventive Cardiology (EAPC). European Journal of Preventive Cardiology (EJPC). 2020:2047487320941993, is available online at: https://doi.org/10.1177/2047487320941993. Background - Tobacco use is the single largest preventable risk factor for premature death of non-communicable diseases and the second leading cause of cardiovascular disease. In response to the harmful effects of tobacco smoking, the use of electronic cigarettes (e-cigarettes) has emerged and gained significant popularity over the past 15 years. E-cigarettes are promoted as safe alternatives for traditional tobacco smoking and are often suggested as a way to reduce or quit smoking. However, evidence suggests they are not harmless. Discussion - The rapid evolution of the e-cigarette market has outpaced the legislator’s regulatory capacity, leading to mixed regulations. The increasing use of e-cigarettes in adolescents and young individuals is of concern. While the long-term direct cardiovascular effects of e-cigarettes remain largely unknown, the existing evidence suggests that the e-cigarette should not be regarded as a cardiovascular safe product. The contribution of e-cigarette use to reducing conventional cigarette use and smoking cessation is complex, and the impact of e-cigarette use on long-term cessation lacks sufficient evidence. Conclusion - This position paper describes the evidence regarding the prevalence of e-cigarette smoking, uptake of e-cigarettes in the young, related legislations, cardiovascular effects of e-cigarettes and the impact of e-cigarettes on smoking cessation. Knowledge gaps in the field are also highlighted. The recommendations from the population science and public health section of the European Association of Preventive Cardiology are presented.

Detecting the concentration of free chlorine is important for monitoring the quality of water. In this study, we report a nanohybrid paper-based chemiresistive sensor that can be used with smartphones to detect free chlorine ions. The sensor was fabricated using a simple and standardized coating process. The graphene and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) nanohybrid paper-based sensing device exhibited a more stable and intuitive response to free chlorine than that exhibited by the device using only PEDOT:PSS. The nanohybrid paper-based sensor was sensitive to free chlorine concentrations in a linear range of 0.1-500 ppm, and the limit of detection was 0.18 ppm. The sensor showed specificity for free chloride ions and detection capability in samples. The sensor was integrated as a module with an electric readout system, and the measured signals and results could be displayed in real time on a smartphone. Therefore, the proposed sensing platform is suitable owing to its portability, low cost, ease of use, and capability for on-site water quality measurement.

Purpose To study respiratory effects of exposure to soft paper dust exposure, a relationship that is rarely studied. Methods Soft tissue paper mill workers at a Swedish paper mill were investigated using a questionnaire and lung function and atopy screening. Spirometry without bronchodilation was performed with a dry wedge spirometer, and forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were obtained and expressed as percent predicted. Exposure to soft paper dust was assessed from historical stationary and personal measurements of total dust, in addition to historical information about the work, department, and production. The impact of high exposure to soft paper dust (> 5 mg/m3) vs. lower exposure ≤ 5 mg/m3, as well as cumulative exposure, was analyzed using multiple linear regression models. Multivariate models were adjusted for smoking, atopy, gender, and body mass index. Results One hundred ninety-eight current workers (124 male and 74 female) were included. There were significant associations between both cumulative exposure and years of high exposure to soft paper dust and impaired lung function. Each year of high exposure to soft paper dust was associated with a 0.87% decrease in FEV1 [95% confidence interval (CI) − 1.39 to − 0.35] and decreased FVC (− 0.54%, 95% CI − 1.00 to − 0.08) compared to the lower exposed workers. Conclusions The present study shows that occupational exposure to soft paper dust (years exceeding 5 mg/m3 total dust) is associated with lung function impairment and increased prevalence of obstructive lung function impairment.

Abstract Tissue paper softness relies on two major factors, the bulk softness, which can be indicated by the elasticity of the sheet, and surface softness. Measurement of surface softness is complicated and often requires a multi-step process. A key parameter defining surface softness is the topography of the surface, particularly the crepe structure and its periodicity. Herein, we present a novel approach to measure and quantify the tissue paper surface crepe structure and periodicity based on the detection of waviness along the sample using laser scanning confocal microscopy (LSM) and X-ray tomography (XRT). In addition, field emission scanning electron microscope (FESEM) was used to characterize the tissue paper surface. We demonstrate that surface topography is directly correlated to the erosion of the doctor blade, which is used to remove the dry tissue paper from the Yankee cylinder. Because of its accuracy and simplicity, the laser confocal microscopy method has the potential to be used directly on the production line to monitor the production process of the tissue paper. XRT revealed more structural details of the tissue paper structure in 3D, and it allowed for the reconstruction of the surface and the internal structure of the tissue paper. Graphic abstract

Objective To compare the effectiveness of silicone sheets and paper tape in the prevention of postoperative cesarean section scars. Methods Patients undergoing horizontal cesarean section were included in this randomized controlled trial. Surgical wounds were divided into two halves. Patients randomly applied silicone sheets or paper tape to each side of their wound as assigned for 3 months. Wounds were assessed at 1, 3, 6, and 12 months after surgery. Researchers used the objective Vancouver Scar Scale (VSS) to evaluate the scars and the subjective visual analog scale (VAS) to evaluate itch, pain, and scar appearance. Results No significant differences between the silicone sheet and paper tape groups were noted at postoperative follow-ups with respect to VSS scores. The silicone sheet group had significantly better VAS scores for scar appearance than the paper tape group at 6 (6.81 ± 1.47 vs 6.19 ± 1.62, P = .03) and 12 (6.88 ± 2.01 vs 6.2 ± 2.08, P = .04) months' follow-up, respectively. Conclusions The silicone sheet group showed statistically significant differences in comparison with the paper tape group in terms of scar appearance as determined by the VAS. However, the differences were too small to be clinically meaningful.

With more than 23 million infections and more than 814,000 deaths worldwide, the coronavirus disease-2019 (COVID-19) pandemic is still far from over. Several classes of drugs including antivirals, antiretrovirals, anti-inflammatory, immunomodulatory, and antibiotics have been tried with varying levels of success. Still, there is lack of any specific therapy to deal with this infection. Although less than 30% of these patients require intensive care unit admission, morbidity and mortality in this subgroup of patients remain high. Hence, it becomes imperative to have general principles to guide intensivists managing these patients. However, as the literature emerges, these recommendations may change and hence, frequent updates may be required. How to cite this article: Juneja D, Savio RD, Srinivasan S, Pandit RA, Ramasubban S, Reddy PK, et al. Basic Critical Care for Management of COVID-19 Patients: Position Paper of Indian Society of Critical Care Medicine, Part-I. Indian J Crit Care Med 2020;24(Suppl 5):S244-S253.

Objectives: The objective of the study was to study the compressive strength of the partially replaced paper mill waste in cement. Methods/ Statistical analysis: The concrete cube specimen were prepared for compressive strength test. In this study, the cement has been replaced with 20%, 30%, 40% and 50% of hypo sludge. The specimens were cured for two different ages (7 days and 28 days) and tested for compressive strength. The quadratic polynomial prediction equation was proposed using Response Surface Methodology (RSM). The prediction model was developed using the experimental output results. Thus, the prediction model facilitates the further research work to be conducted by researchers on paper mill waste replacement. The rate analysis was also further carried out to show the cost effectiveness of using the waste replacement in cement. Findings: The test was conducted on the compressive strength (7 days and 28 days) of control specimen (0%) and partial replacement of 20%, 30%, 40% and 50% of cement using the hypo sludge. Thus, 20% replacement of cement using hypo sludge has shown good compressive strength than the control specimen. The cost of 20% paper mill waste was less when compared to the cost of control specimen. Novelty/ Applications: The compressive strength of 20% partial replacement of paper mill waste in cement can be used in further construction. The prediction model can be used to predict the future compressive strength of partially replaced paper mill waste concrete. Keywords: Ordinary Portland cement; Paper mill waste; Hypo sludge; Partial replacement; RSM

Objective: To compare the effectiveness of mobile video-guided home exercise program and standard paper-based home exercise program. Methods: Eligible participants were randomly assigned to either experimental group with mobile video-guided home exercise program or control group with home exercise program in a standard pamphlet for three months. The primary outcome was exercise adherence. The secondary outcomes were self-efficacy for exercise by Self-Efficacy for Exercise (SEE) Scale; and functional outcomes including mobility level by Modified Functional Ambulatory Category (MFAC) and basic activities of daily living (ADL) by Modified Barthel Index (MBI). All outcomes were captured by phone interviews at 1 day, 1 month and 3 months after the participants were discharged from the hospitals. Results: A total of 56 participants were allocated to the experimental group [Formula: see text] and control group [Formula: see text]. There were a significant between-group differences in 3-months exercise adherence (experimental group: 75.6%; control group: 55.2%); significant between-group differences in 1-month SEE (experimental group: 58.4; control group: 43.3) and 3-month SEE (experimental group: 62.2; control group: 45.6). For functional outcomes, there were significant between-group differences in 3-month MFAC gain (experimental group: 1.7; control group: 1.0). There were no between-group differences in MBI gain. Conclusion: The use of mobile video-guided home exercise program was superior to standard paper-based home exercise program in exercise adherence, SEE and mobility gain but not basic ADL gain for patients recovering from stroke.

The recycling of waste paper has been an effective way to achieve the environmental-friendly growth of papermaking industry. Focusing on the mixed-pulping process which has been generally employed, to ensure the required properties of the deinking pulp (DIP) and minimize the purchase cost of waste paper, an intelligent model scheduling the mixing ratio of waste paper was developed in the study. Primarily, driven by the field data of mixing ratio of waste paper and DIP properties, the prediction models of DIP properties were developed by SVM, GA-SVM, and BP-NN algorithms. Subsequently, based on the best prediction model, the scheduling model for the mixing ratio of waste paper was set up by NSGAII algorithm. The experimental results showed that, based on the obtained best BP-NN prediction model of DIP properties, the developed NSGAII scheduling model for the ratio of waste paper could achieve excellent scheduling results under the rigorous constraints and multi-objective. Compared with the previous study, the developed prediction and scheduling models in this study reduced the purchase cost of waste paper by 2.16%, and improved the acceptable proportion of DIP property from 56.07% to 100%.

Reflective liquid crystal displays are attracting attention as portable information systems because of zero- or extremely low power consumption. In this study, we deal with an electrode-free reflec...

Microfluidic paper-based analytical devices (μPADs) allow user-friendly and portable chemical determinations, although they provide limited applicability due to insufficient sensitivity. Several approaches have been proposed to address poor sensitivity in μPADs, but they frequently require bulky equipment for power and/or read-outs. Universal serial buses (USB) are an attractive alternative to less portable power sources and are currently available in many common electronic devices. Here, USB-powered μPADs (USB μPADs) are proposed as a fusion of both technologies to improve performance without adding instrumental complexity. Two ITP USB μPADs were developed, both powered by a 5 V potential provided through standard USB ports. The first device was fabricated using the origami approach. Its operation was analyzed experimentally and numerically, yielding a two-order-of-magnitude sample focusing in 15 min. The second ITP USB μPAD is a novel design, which was numerically prototyped with the aim of handling larger sample volumes. The reservoirs were moved away from the ITP channel and capillary action was used to drive the sample and electrolytes to the separation zone, predicting 25-fold sample focusing in 10 min. USB μPADs are expected to be adopted by minimally-trained personnel in sensitive areas like resource-limited settings, the point-of-care and in emergencies. Fil: Schaumburg, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Kler, Pablo Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones en Métodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones en Métodos Computacionales; Argentina Fil: Carrell, Cody S.. State University of Colorado - Fort Collins; Estados Unidos Fil: Berli, Claudio Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina Fil: Henry, Charles S.. State University of Colorado - Fort Collins; Estados Unidos

Electromagnetic interference (EMI) shielding materials with high performance and low density are urgently needed with the rapid development of electronic communications. In this work, tuning solid–air interface of graphene paper was carried out to enhance multiple reflections of incident electromagnetic waves for high-performance EMI shielding. The large amount solid–air interface (57.8 m2 g−1) endowed the porous graphene paper with a high EMI shielding effectiveness (SE) of 31.0 dB, 50% enhancement from its counterpart of solid graphene paper. This porous graphene paper also showed an ultralow density of 0.02 g cm−3, an 18.5-fold decrease from its counterpart of solid graphene paper. Moreover, the EMI SE of obtained graphene papers exhibited proportional relationship with their specific surface area, further confirming the vital role of solid–air interface in the enhancement of EMI shielding. This work quantitatively demonstrates the significance of solid–air interface area for enhancing the EMI shielding performance and proposes an efficient guideline for the design of high-performance and low-density EMI shielding materials.

This ESH Position Paper 2021 with updated proposed recommendations was deemed necessary after the publication of a set of new pivotal sham-controlled randomized clinical trials (RCTs), which provided important information about the efficacy and safety of endovascular device-based renal denervation (RDN) for hypertension treatment. RDN is effective in reducing or interrupting the sympathetic signals to the kidneys and decreasing whole body sympathetic activity. Five independent, fully completed, sham-controlled RCTs provide conclusive evidence that RDN lowers ambulatory and office blood pressure (BP) to a significantly greater extent than sham treatment. BP-lowering efficacy is evident both in patients with and without concomitant antihypertensive medication. The average decrease of 10mmHg in office BP is estimated to lower the incidence of cardiovascular events by 25-30%, based on meta-analyses of RCTs using pharmacological treatment. Neither peri-procedural, nor short-term or long-term adverse events or safety signals (available up to 3 years) have been observed. Implementing RDN as an innovative third option in the armamentarium of antihypertensive treatment requires a structured process that ensures the appropriate performance of the endovascular RDN procedure and adequate selection of hypertensive patients. The latter should also incorporate patients' perspective and preference that needs to be respected in a shared decision-making process.

Life expectancy of power transformers is limited by the integrity of insulating cellulosic paper wound around transformer winding. The insulating paper is subjected to thermal, electrical and mechanical stresses. There are three main factors causing degradation in the paper, i.e. moisture, oxygen and temperature. In this work, the degradation rate due to temperature is only discussed. That means that transformer life could be shortened or extended by adjusting loads which results in higher or lower temperature conditions. The temperature, namely the hot-spot temperature is typically used to estimate the relative ageing rate and loss of insulation life. Being able to estimate the hot-spot temperature accurately given load and weather data helps operators to plan about transformer replacement properly. This could also reduce costs of early replacement due to a conservative estimation. In this work, thermal models have been developed using machine learning techniques to learn thermal behavior from historical data. The data are comprised of the hot-spot temperature estimated by winding temperature indicator (WTI), load profiles, ambient temperature, rainfall, wind speed and direction and solar radiation. The proposed method has been validated using data for five 400kV/275kV, four 400kV/132kV and two 275kV/66kV autotransformers and has been shown to work effectively.

The development of renewable energy sources minimizes the burning of fossil fuels for clean and green environment. Electrochemical energy storage/conversion device pays a way towards sustainable development that concludes an emerging field in the trends of the research community. Prominently, the functional materials with suitable structure and property determine the performance and durability of the devices. In recent times, graphene with its tremendous properties play a major role in electrochemical energy device applications. Meanwhile, the graphene-based electrodes were fabricated by various coating techniques on existing electrodes that utilized for energy device fabrication. Apart from these, it is also fabricated in a paper like a form (self-supported or free-standing) with its remarkable high conductivity, flexibility, robustness and electrochemical behavior which have been nominated for fabrication of flexible energy devices. Paper-like electrodes become an emerging field to fabricate a light-weight and flexible electronic devices for future prospects. Thus, we have summarized a synthetic strategy of graphene paper and its properties that potentially focused on flexible device fabrication in both the energy storage and conversion system. Hence, this review boosts up the forthcoming researchers to enhance the device performance with interrelating free-standing graphene and other host material.

In most cases, three-dimensional paper-based microfluidic analytical devices (3D-μPADs) were fabricated manually by stacking or folding methods. For the first time, digital light processing stereolithography (DLP-SLA) 3D printing technology was adopted to automatically make 3D-μPADs. In the fabrication process, a printing pause was set between two layers to allow paper to be placed in the resin tank. The resin on the fresh paper spontaneously bonded to the former cured paper layer during curing, thus realizing the automatic bonding and alignment between different layers of paper and avoiding the human participation and errors as in stacking and folding methods. There was a gap between two vertical aligned flow paths, therefore the liquid did not flow spontaneously from the upper layer to the lower layer. Most of the fluid flow in 3D-μPADs was spontaneous or manually activated, which was not conducive to complex assays that require different regents to be delivered sequentially. Herein, we used an electric field or airflow to trigger the fluid flow and demonstrated the flow controllability by a proof-of-concept colorimetric assay. The limits of detection of glucose and albumin were 0.8 mM and 3.5 μM, respectively, which were sufficient for clinical requirements. Given the characteristic of flow controllability, we believe that the proposed 3D-μPADs have great potential to make paper-based complex assays automated and programmable.

Objective: This study mainly focussed how foldscope can be used as an efficient viewable tool to detect in morphological and anatomical investigation of various bioactive medicinal plants. Microscope provides a beneficial instrument for visualization of living cells. Its cost is very high which is not affordable for rural based educational institutes. Foldscope is the ultra-affordable and versatile, paper microscope designed to be extremely portable, durable and to give optical quality similar to conventional research microscopes. Methods: For enhancing scientific temperament among rural children, Indian Born Scientist (Dr. Manu Prakash) has introduced an ultra-low-cost foldable origami-based approach for large-scale manufacturing of microscope, specifically demonstrating bright field, dark field and fluorescence microscopes. However, its potential as in research tool in the area of aromatic medicinal plants is still not known. The slides were prepared by own and were observed with the magnification power of 140X. Results: The result of the present study reported that the Foldcsope images revealed viable stained areas in the respective plant parts like trichomes, stomata, pollen grains, stem and leaf of different medicinal plants and indicating their live activities. Conclusion: Based on the attractive images captured from the Foldscope, the uses of foldscope were recommended to public. Previously we had organized some awareness cum demonstration programme regarding foldscope and its applications in the field of science education in the different educational institute of Erode District, Tamilnadu. Based on the clarity of images and easy handling of Foldscope the uses of origami microscope were recommended for higher studies.

This paper presents a new approach towards the design of paper based autonomous microfluidic devices. Autonomy in the device operation is achieved through the incorporation of mechanically actuated microfluidic switches that are versatile in their design and may be configured to be simple time triggered ON or OFF switches or more complex switches that can be timed to be in multiple states (timed ON, followed by timed OFF). These switches are self-contained and require no external power for their operation, deriving their functionality solely through stored elastic energy. This paper presents the design and fabrication of these switches as fluidic analogs of electronic transistors, and their integration into microfluidic paper based circuit demonstrating their operation as a programmable paper-based microfluidic device.

Enzyme use has provided boost to the technoeconomics of many industrial processes. In this chapter, we summarize different cellulase-based industrial processes for preparation of paper, pulp, brewing products, and different foods. This review presents a brief chemistry and mechanism of cellulose degradation by the cellulase enzyme. Also, cellulase production abilities of many microbial species have been addressed in this chapter. Cellulase plays a major role in production of good-quality paper and pulp. It’s used to debark the biomass and to remove lignocellulosic part. This enzyme also has application in recycling of used paper by deinking and biobleaching. Cellulase enhances freeness and drainage ability of the fibers without compromising the brightness of the fibers. In brewing industry, cellulase in combination of other enzymes is used to extract the more sugar for better-quality alcohol production. Cellulases have a wide range of potential applications in food and beverage processing, production of fruit and vegetable juices, and improvement of methods for extraction, clarification, and stabilization.

In recent era of modern and bendable technology, energy dearth arises as a paramount subject around the globe with a dire demand of flexible and lightweight energy storage devices. This study targets fabrication of reduced graphene oxide (rGO) and utility of abundantly available, cost effective, and environment friendly lignocelluloses (LC) fibers extracted from Carica papaya source, as a binder to bind active material (rGO) as robust and compact paper sheet. Fabricated samples were analyzed by X-ray diffraction for crystallographic analysis, Scanning electron microscopy, Transmission electron microscope for morphology, Fourier transform infrared spectroscopy for structural bonding, and Raman spectroscopy for vibrational modes. Robust and bendable rGO/LC paper electrode was tested for energy storage application by employing in different characterizations, i.e., cyclic voltammetry for capacitive behavior, galvanostatic charge–discharge for symmetric EDLC, and electrochemical impedance spectroscopy for resistive charge kinetics, respectively. rGO/LC composite sheet employed as working electrode in 3-electrode CV measurements and revealed specific capacitance of 591 F/g at a scan rate of 5 mV/s by keeping the undistorted shape of voltammograms at higher scan rates which present it as a suitable candidate for modern flexible and energy storage devices. rGO/LC-based symmetric cell revealed the highest specific capacitance of 228 F/g at applied current density of 0.1 A/g, the energy density of 6.3 Wh/kg, and power density of 129 W/kg, respectively. rGO/LC-based symmetric cell confirmed the cycling stability by revealing capacitance retention of 82% after 200 cycles. It can conclude that biomass-based rGO paper sheet can be a potential candidate as environmentally safe with remarkable electrochemical activity in energy storage applications.

Although cellular transplantation remains a relatively small field compared to solid organ transplantation, the prospects for advancement in basic science and clinical care remain bountiful. In this review, notable historical events and the current landscape of the field of cellular transplantation are reviewed with an emphasis on islets (allo- and xeno-), hepatocytes (including bioartificial liver), adoptive regulatory immunotherapy, and stem cells (SCs, specifically endogenous organ-specific and mesenchymal). Also, the nascent but rapidly evolving field of three-dimensional bioprinting is highlighted, including its major processing steps and latest achievements. To reach its full potential where cellular transplants are a more viable alternative than solid organ transplants, fundamental change in how the field is regulated and advanced is needed. Greater public and private investment in the development of cellular transplantation is required. Furthermore, consistent with the call of multiple national transplant societies for allo-islet transplants, the oversight of cellular transplants should mirror that of solid organ transplants and not be classified under the unsustainable, outdated model that requires licensing as a drug with the Food and Drug Administration. Cellular transplantation has the potential to bring profound benefit through progress in bioengineering and regenerative medicine, limiting immunosuppression-related toxicity, and providing markedly reduced surgical morbidity.

Although Al-ion battery is attracting researchers’ attention worldwide, its volumetric energy density was not so promising due to low density of graphite-based positive electrodes in the current published literatures. Thus, defect-free yet densely packed graphene electrodes with high electronic conductivity and fast ionic diffusion are crucial to the realization of compacted Al-ion batteries with high volumetric energy density. In the present work, a self-supported and defect-free graphene-positive electrode (RHG-P-2850) was successfully produced by a hydriodic acid reduction of the graphene oxide (GO) method, followed by an ultrahigh temperature (2850 °C) annealing treatment. The density of the RHG-P-2850 (0.32 g cm−3) is currently the highest positive electrode material in the preparation of graphene-positive electrodes from GO. RHG-P-2850 positive electrode enables to deliver considerably high specific capacity 27.1 mAh cm−3 (85 mAh g−1) at the current density 2 A g−1. More importantly, a remarkably stable performance was achieved with 20% fading over 8000 cycles. The results enlighten and promote the design and preparation of densely packed graphene-positive electrode to develop high-performance Al/graphene battery.

Nowadays, the needs of bendable energy storage components are growing to match with the development of wearable devices. However, it is still a great challenge to fabricate flexible electrodes to k...

The imbalance between the prevalence of patients with acute respiratory failure (ARF) and acute-on-chronic respiratory failure and the number of intensive care unit (ICU) beds requires new solutions. The increasing use of non-invasive respiratory tools to support patients at earlier stages of ARF and the increased expertise of non-ICU clinicians in other types of supportive care have led to the development of adult pulmonary intensive care units (PICUs) and pulmonary intermediate care units (PIMCUs). As in other European countries, Italian PICUs and PIMCUs provide an intermediate level of care as the setting designed for managing ARF patients without severe non-pulmonary dysfunction. The PICUs and PIMCUs may also act as step-down units for weaning patients from prolonged mechanical ventilation and for discharging patients still requiring ventilatory support at home. These units may play an important role in the on-going coronavirus disease 2019 pandemic. This position paper promoted by the Italian Thoracic Society (ITS-AIPO) describes the models, facilities, staff, equipment, and operating methods of PICUs and PIMCUs.

Brain-machine interfaces (BMIs) decode neural activity in real-time, allowing control of sensors and actuators. However, real-time neural decoding requires high computational resources. Recently developed paper-based electronics (e.g., transistors) are likely to reduce the cost of computing devices. In this theoretical study, we propose a roadmap to develop BMIs that take advantage of cellulose based supercomputers. Major milestones will include: 1) an initial prototype with a small number of elements capable of forming a simple brain-controlled On/Off switch, and 2) scaling up the capabilities of the new computing device, such that paper-based electronics lined in the walls of people’s homes will form a supercomputer. The initial prototype will be used to control the lights in a room, but more advanced devices are expected to decode more complex brain commands. As paper-based electronics are very low cost, it is proposed here that paper-based supercomputing capabilities may significantly improve BMIs.

Objective This study collected randomized controlled trials (RCTs) published in the social sciences in China and assessed their risk of bias and reporting quality. Study Design and Setting Three databases were systematically searched for publications from January 2000 to June 2020 for RCTs in the social sciences published by Chinese researchers. The risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool (CCRBT), and reporting quality was assessed using the Consolidated Standards of Reporting Trials for Social and Psychological Interventions (CONSORT-SPI). Results A total of 316 RCTs were identified, including 204 articles in English and 112 articles in Chinese. The most frequently researched interventions focused on education (33.9%), and the most frequently studied population were students (32.9%). Eighty-seven percent of RCTs had intermediate reporting quality. Twenty-four of the 43 CONSORT-SPI sub-items had a compliance rate of less than 50%. Most RCTs had an unclear risk of bias for blinding outcome assessors (84.5%), blinding participants and personnel (82.9%), allocation concealment (73.1%), and random sequence generation (68.0%). A low proportion of CONSORT-SPI items were reported and, high proportion of the papers had unclear risk of bias. Conclusion The quality and reporting of RCTs in the social sciences needs improvement in China, especially for reporting methods and results. Most studies had an unclear risk of bias as they lacked important methodological information.

Contains fulltext : 237219.pdf (Publisher’s version ) (Open Access) Objective: To describe characteristics of randomised controlled trials (RCTs) conducted using electronic health records (EHRs), including completeness and transparency of reporting assessed against the 2021 CONSORT Extension for RCTs Conducted Using Cohorts and Routinely Collected Data (CONSORT-ROUTINE) criteria. Study design: MEDLINE and Cochrane Methodology Register were searched for a sample of RCTs published from 2011–2018. Completeness of reporting was assessed in a random sample using a pre-defined coding form. Results 183 RCT publications were identified; 122 (67%) used EHRs to identify eligible participants, 139 (76%) used the EHR as part of the intervention and 137 (75%) to ascertain outcomes. When 60 publications were evaluated against the CONSORT 2010 item and the corresponding extension for the 8 modified items, four items were 'adequately reported' for the majority of trials. Five new reporting items were identified for the CONSORT-ROUTINE extension; when evaluated, one was 'adequately reported', three were reported 'inadequately or not at all', the other 'partially'. There were, however, some encouraging signs with adequate and partial reporting of many important items, including descriptions of trial design, the consent process, outcome ascertainment and interpretation. Conclusion: Aspects of RCTs using EHRs are sub-optimally reported. Uptake of the CONSORT-ROUTINE Extension may improve reporting. 12 p.

The use of membranes in integrated water systems has garnered increasing attention in paper mills operating with virgin fibres, with documented closed water loops in industry. However, limited research exists on the performance of ultrafiltration (UF) in mills operating with 100% recycled fibres (RCF) and closed water systems, as these result in the introduction and accumulation of insoluble contaminants in the effluent. This study investigated the effect of transmembrane pressure (TMP) and feed organic load on the flux, types of fouling, and organic separation with UF membranes in a recycled paper mill using 100% RCF. The high feed organic load caused inevitable fouling, limiting the highest achievable flux. However, the TMP could be manipulated to improve on or exacerbate the process performance, within the range that was set as a result of the feed's characteristics. Low TMP (1.35 bar) generated the highest permeability and chemical oxygen demand removal, while higher TMPs produced higher fluxes and recoveries. The process was characterised by high initial fluxes, followed by cake formation, which dominated, and pore blockage. The excess cake formation induced cake filtration. This study shows the potential of UF membranes to be used as pre-treatment in filtering the process water in a recycled paper mill operating with 100% RCF, a critical step forward in implementing an integrated water system, and eventually closing the water loop.

BACKGROUND: Ultrafiltration (UF) technology is efficient in treating wastewater. However, membrane fouling during filtration process affects the performance of UF to a large extent. Pretreatment prior to UF is important for enhancing membrane performance, reducing membrane fouling and extending the membrane lifetime. RESULTS: In this study, two pretreatment technologies, including coagulation and Fenton, were applied individually before UF for treating secondary effluent (SE) from recycled paper mill. Results exhibited that direct membrane filtration got the highest flux loss and worst membrane fouling compared with performances of those conducting pretreatments. Compared to coagulation + UF, Fenton + UF had superior performance in reducing dissolved organics with a COD rejection of 91.81%, and mitigating membrane fouling with a stable flux of 133 J m⁻² h⁻¹. GPC results further showed that Fenton pretreatment degraded macromolecules into smaller organic compounds. In addition, the classical blocking filtration laws were employed to scrutinize the fouling alleviation mechanism of pretreatments. CONCLUSION: Pretreatments prolonged the transition from pore blocking to cake filtration, thereby reducing fouling. Among them, Fenton was a promising pretreatment method prior to UF for treating recycled paper SE. © 2018 Society of Chemical Industry

Civil Construction Industry impacts significantly the environment, being one of the most critic factors related to elevated production of Civil Construction Residue (CCR). Among CCR produced, the Kraft paper package acquires notoriety, due their large use on material packaging, such as Portland cement and lime, then, present a high production rate and offer contamination potential, lack of collection logistics and nearly any reuse. In this scenario, the study and development of alternative constructive materials which applies the sustainability concept and CCR recycling have acquired great relevance in the sector. It is highlighted the residue incorporation on masonry soil-cement blocks, due its block are not submitted to the sintering process. Then, the present research intend to study adobe blocks mechanical properties based on soil-cement reinforced with cellulose fibers obtained from Kraft paper recycling. The bricks were confectioned with 7% Portland cement content and with 0%, 8%, 10% e 12% Kraft paper fiber addition, being submitted to compressive strength test, water absorption test, durability test with wetting and drying and retraction analysis. It was verified the confectioned composites presented as a viable and interesting alternative on technical and environment range. All studied researches presented null retraction and compressive strength increase on cracked state, toughness increase and good performance about durability.

L -dopa is a chiral drug that has been extensively used for the treatment of Parkinson’s disease. The concentration of L -dopa plays a vital role in the treatment, and this work emphasizes on designing a versatile platform for the quantitative and selective detection of L -dopa using reduced graphene quantum dot (rGQD). The platform is efficient in three different sensing methods, viz. fluorescence turn-on, filter paper-based sensing, and electronic measurements. The rGQD undergoes a dramatic fluorescence turn-on in the presence of L -dopa in aqueous media and artificial urine with a detection limit as low as 1.307 µM and 1.217 µM respectively. Experimental evidence revealed that the fluorescence enhancement is attributed to aggregation-induced emission mechanism. The system is also applicable for visual detection of L -dopa using filter paper strips treated with rGQD and develops bright fluorescence under ultra-violet irradiation. Apart from this, electrical sensors for L -dopa were also developed by preparing rGQD treated poly-vinyl alcohol films, and the increase in the current conduction with varying concentrations of L -dopa was observed. The films produce 2.5 order higher current conduction at 300 μM of L -dopa with a detection limit of about 13.136 µM. At the final stage, we have designed flexible electronic devices using these materials that develop 1.3 order higher current for L -dopa. The devices exhibit excellent air stability under varied relative humidity conditions as well as high bending stability for potential practical applications.

Traction transformers are one of the most important equipment in the traction power supply system. Thermal aging of transformer insulation system determines its reliable life. To achieve an estimation of the insulation life of traction power transformers operated under real load condition, the effects of traction loads on the thermal aging of oil-paper insulation in traction transformers were investigated. First, the design principles for the accelerated thermal aging experiment were studied and proposed by considering magnitude (i.e., load rate) and frequency (i.e. spare time and lasting time) of the traction load. Then, an experimental system was established in the laboratory to conduct extensive accelerated thermal aging experiments, in which the traction loads were mimicked by using positive temperature coefficient (PTC) heating plates and a programmable logic controller (PLC). Finally, the experimental results were analyzed and discussed to reveal the effects of traction load on the thermal aging of oil-paper insulation in traction transformers.

Background We use inkjet printing and film adhesion methods to economically develop paper-based electrowetting-on-dielectric (EWOD) mixing device. Because the periodic shrinking and stretching of droplet contact line induces surface capillary wave, the coalesced droplet on EWOD device vibrates to accelerate solute mixing on the merged spot. Methods An office inkjet printer fabricates pads of conducting silver nanoparticles to compose EWOD activation electrodes on a piece of glossy label paper, covered with one oil-coated dielectric film. Using the triggering relays of each pad, two droplets of thirty microliter individually loaded on the electrode ends are driven to coalesce. Alloy nanorod-catalyzed chemiluminescence assay can be performed on this mixing device. Findings When ac voltage of 100 Hz is applied on the electrode flakes, compared with solute transport efficiency in static condition, solute diffusivity is enhanced by 4 times using this mixing device. Linear relation (R2 = 0.99) between luminescence intensity acquired with smartphone camera and luminol concentration of aforementioned chemiluminescence assay is obtained, demonstrating reproducibility improvement for accurate determination.