1. NIR-Laser-Controlled Drug Release from DOX/IR-780-Loaded Temperature-Sensitive-Liposomes for Chemo-Photothermal Synergistic Tumor Therapy
- Author
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Hao Wu, Hongmei Liu, Xin Liu, Min Pan, Yekuo Li, Yuli Zhou, Wanlu Duan, Hairong Zheng, and Fei Yan
- Subjects
Temperature-sensitive-liposome ,Indoles ,Infrared Rays ,Medicine (miscellaneous) ,Antineoplastic Agents ,Breast Neoplasms ,Breast tumors ,02 engineering and technology ,Pharmacology ,010402 general chemistry ,01 natural sciences ,Mice ,Drug Therapy ,Temperature sensitive liposomes ,In vivo ,IR-780 ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Doxorubicin ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Drug Carriers ,Chemistry ,Lasers ,Tumor therapy ,Photothermal therapy ,021001 nanoscience & nanotechnology ,Combined Modality Therapy ,In vitro ,0104 chemical sciences ,Disease Models, Animal ,Drug Liberation ,Treatment Outcome ,Photochemotherapy ,Apoptosis ,Liposomes ,Drug release ,Heterografts ,0210 nano-technology ,Research Paper ,medicine.drug - Abstract
NIR laser-induced photothermal therapy (PTT) through near-infrared agents has demonstrated the great potential in solid tumor ablation. However, the nonuniform heat distribution over tumors from PTT makes it insufficient to kill all tumor cells, resulting in tumor recurrence and inferior outcomes. To improve the tumor treatment efficacy, it is highly desirable to develop the combinational treatment of PTT with other modalities, especially with chemotherapeutic agents. Here we report a smart DOX/IR-780-loaded temperature-sensitive-liposome (DITSL) which can achieve NIR-laser-controlled drug release for chemo-photothermal synergistic tumor therapy. In this system, the liposoluble IR-780 was incorporated into the temperature-sensitive lipid bilayer and the soluble chemotherapeutic doxorubicin (DOX) was encapsulated in the hydrophilic core. The resulting DITSL is proved to be physiologically stable and can provide a fast and laser irradiation-controllable DOX release in the PBS and cellular conditions. We further employed this nanoparticle for tumor treatment, demonstrating significantly higher tumor inhibition efficacy than that of DOX-loaded temperature-sensitive-liposome (DTSL) or IR780-loaded temperature-sensitive-liposome (ITSL) in the in vitro cells and in vivo animals. Histological analysis further revealed much more apoptotic cells, confirming the advantageous anti-tumor effect of DITSL over DTSL or ITSL. Our study provides a promising strategy to realize chemo-photothermal synergistic combination therapy for breast tumors.
- Published
- 2016