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NIR-Laser-Controlled Drug Release from DOX/IR-780-Loaded Temperature-Sensitive-Liposomes for Chemo-Photothermal Synergistic Tumor Therapy
- Source :
- Theranostics
- Publication Year :
- 2016
- Publisher :
- Ivyspring International Publisher, 2016.
-
Abstract
- NIR laser-induced photothermal therapy (PTT) through near-infrared agents has demonstrated the great potential in solid tumor ablation. However, the nonuniform heat distribution over tumors from PTT makes it insufficient to kill all tumor cells, resulting in tumor recurrence and inferior outcomes. To improve the tumor treatment efficacy, it is highly desirable to develop the combinational treatment of PTT with other modalities, especially with chemotherapeutic agents. Here we report a smart DOX/IR-780-loaded temperature-sensitive-liposome (DITSL) which can achieve NIR-laser-controlled drug release for chemo-photothermal synergistic tumor therapy. In this system, the liposoluble IR-780 was incorporated into the temperature-sensitive lipid bilayer and the soluble chemotherapeutic doxorubicin (DOX) was encapsulated in the hydrophilic core. The resulting DITSL is proved to be physiologically stable and can provide a fast and laser irradiation-controllable DOX release in the PBS and cellular conditions. We further employed this nanoparticle for tumor treatment, demonstrating significantly higher tumor inhibition efficacy than that of DOX-loaded temperature-sensitive-liposome (DTSL) or IR780-loaded temperature-sensitive-liposome (ITSL) in the in vitro cells and in vivo animals. Histological analysis further revealed much more apoptotic cells, confirming the advantageous anti-tumor effect of DITSL over DTSL or ITSL. Our study provides a promising strategy to realize chemo-photothermal synergistic combination therapy for breast tumors.
- Subjects :
- Temperature-sensitive-liposome
Indoles
Infrared Rays
Medicine (miscellaneous)
Antineoplastic Agents
Breast Neoplasms
Breast tumors
02 engineering and technology
Pharmacology
010402 general chemistry
01 natural sciences
Mice
Drug Therapy
Temperature sensitive liposomes
In vivo
IR-780
Cell Line, Tumor
medicine
Animals
Humans
Doxorubicin
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Drug Carriers
Chemistry
Lasers
Tumor therapy
Photothermal therapy
021001 nanoscience & nanotechnology
Combined Modality Therapy
In vitro
0104 chemical sciences
Disease Models, Animal
Drug Liberation
Treatment Outcome
Photochemotherapy
Apoptosis
Liposomes
Drug release
Heterografts
0210 nano-technology
Research Paper
medicine.drug
Subjects
Details
- ISSN :
- 18387640
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Theranostics
- Accession number :
- edsair.doi.dedup.....ea1f1a28bc04a1615d6747d9ddd942da