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Nonequilibrium Population Dynamics of Phenotype Conversion of Cancer Cells
- Source :
- PLoS ONE, Vol 9, Iss 12, p e110714 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Tumorigenesis is a dynamic biological process that involves distinct cancer cell subpopulations proliferating at different rates and interconverting between them. In this paper we proposed a mathematical framework of population dynamics that considers both distinctive growth rates and intercellular transitions between cancer cell populations. Our mathematical framework showed that both growth and transition influence the ratio of cancer cell subpopulations but the latter is more significant. We derived the condition that different cancer cell types can maintain distinctive subpopulations and we also explain why there always exists a stable fixed ratio after cell sorting based on putative surface markers. The cell fraction ratio can be shifted by changing either the growth rates of the subpopulations (Darwinism selection) or by environment-instructed transitions (Lamarckism induction). This insight can help us to understand the dynamics of the heterogeneity of cancer cells and lead us to new strategies to overcome cancer drug resistance.
- Subjects :
- Drug Research and Development
Cellular differentiation
Population
Population Modeling
lcsh:Medicine
Biology
medicine.disease_cause
Hematologic Cancers and Related Disorders
Leukemias
Breast Tumors
Basic Cancer Research
Drug Discovery
Medicine and Health Sciences
medicine
lcsh:Science
education
Pharmacology
Genetics
education.field_of_study
Multidisciplinary
Cell growth
Systems Biology
lcsh:R
Biology and Life Sciences
Computational Biology
Cancers and Neoplasms
Hematology
Cell Fraction
Cell sorting
Phenotype
Oncology
Evolutionary biology
Cancer cell
lcsh:Q
Clinical Medicine
Carcinogenesis
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ded6ffdf24d517aae91bb359c400554c