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Maintaining of the proper predetermined paper pulp consistency on the different stages of the paper or cardboard manufacturing process significantly affects on quality and self cost of manufactured articles. The improvement of precision and repeatability of the paper pulp viscosity and consistency measurements is relevant to paper industry. Objective of the work is to improve the industrial-type paper pulp rotational consistometer. A new method for measurement of paper pulp concentration by means of a rotational viscometer was suggested which enables determining the flow consistency index K and flow behavior index n in the Ostwald-de Waele power law. The influence of the following torques on the measurement results is eliminated thanks to the new method: the friction torque in the seal of the sensitive element, the friction torque in the bearings of the shaft and the torque created under the influence of the flow with distorted flow speed profile. This is achieved by measuring the torque which acts on the sensitive element approaching the selected frequencies of sensitive element rotation both from the lower and higher frequencies. The mean torque value is calculated based on the obtained values. The measurements are conducted for two sensitive element rotation frequencies adjusted in advance. The frequency of sensitive element rotation is changed by means of a frequency converter. It is shown that by using two different rotation frequencies of the sensitive element of a rotational viscometer it is possible to define the flow consistency index and the flow behavior index. Paper pulp viscosity and consistency is defined on the basis of these two indexes. It is also suggested to average the results of viscous friction torque measurement approaching the rotation frequency of the viscometer sensitive element to the working frequency chosen for measurement from the lower and higher frequency ranges. By averaging the results of such measurement the friction torques in sealing and bearings supporting the sensitive element shaft are compensated. By changing the rotation direction of the sensitive element and by further averaging the obtained results it is possible to eliminate the influence of the asymmetrical distribution of paper pulp flow speed in the pipeline. This improves accuracy of the paper pulp consistency measurement.

Lipoedema is a chronic progressive disorder of adipose tissue leading to an enlargement of lower extremities. It is considered to be rare; however, the prevalence of the disease is underestimated because it is commonly misdiagnosed as obesity or lymphedema and the general awareness is poor. The etiology of the disorder is considered to be multifarious, including genetic inheritance, hormonal imbalance and microcirculation alterations. Diagnosis is mainly based on medical history and physical examination. Management of lipoedema is focused on reducing the symptoms, improving the quality of life and preventing further progression of the disease. The aim of this paper is to raise the awareness of the disease and provide appropriate clinical guidance for the assessment of lipoedema. We searched through the PubMed/MEDLINE database and took into consideration all of the results available as of 6September, 2020 and outlined the current evidence regarding lipoedema epidemiology, etiology, clinical presentation, differential diagnosis, and management. Better understanding of lipoedema is crucial for establishing an early diagnosis and a proper treatment, which in turn will reduce the psychological and physical implications associated with the disease.

Admission Dysfunctions of the lumbosacral spine are among the most common problems related to the movement of contemporary society throughout the world, and its incidence increases with age. In recent years, increased interest in the issues fascia, which until recently was neglected in the etiology of low back pain. One of the therapeutic options that can be applied in the case of chronic pain syndrome lumbar-sacral spine techniques are easing myofascial (ang. Myofascial release, MFR), which is one of the latest methods in the field of manual medicine. Objective of the work The aim of the work was overview AD recently published study on the effectiveness of techniques easing myofascial pain in chronic lumbar-sacral spine. Material and methods To find the current investigate research (publications of the last 5 years) dedicated to MFR in the treatment of chronic pain, lumbar-sacral spine searched the following databases: PubMed, PEDro (Physiotherapy Evidence Database), ScienceDirect and Academic Search Premier. The following keywords: myofascial release, myofascial release therapy, myofascial pain, chronic low back pain. Results 9 qualified to review the studies investigating the effect of loosening myofascial pain and range of motion, functional limitations, muscles, as well as the quality of life in people with chronic pain lumbosacral spine. Conclusions The results of this review show that there is little research on the MFR employs treat ailments low back pain lumbar - sacral. Based on the studies included in this review can be concluded that the MFR can be an effective treatment for back pain lumbar - sacral, but there is a need for further research with a well-developed research procedure that will allow the standardization of this therapeutic method.

The conducted study has shown problems with electronic documents already in the moment of their accession, as well as arrangement and description, storage and providing access to them in the archive. It turned out that, unfortunately, electronic documents are treated only as an addition to paper versions of materials. The study uses method of document analysis (including electronic document), as well as a survey – a questionnaire. The object of the study was a private papers of Professor Stanisław Gorgolewski.

The problems of the creation of the basic reasons of Ukrainian nation’s political identity in the context of cultural and political dimension have been revealed in the article. It has been found that Cyril and Methodians understood the reasons of political division, which had historical and spiritual background. It has been shown that members of Cyril and Methodiy’s company tried to determine the variations of directions in the development of national and political unity and to determine the Ukrainian national - cultural priorities. They argued that the Ukrainian mentality had been formed on the basis of the following dominant principles: respect to the family, esthetical love to their native land, rational and ethical attitude and respect to human life. It has been indicated, that Cyril and Methodians had proven the idea about the state of the national culture, which had transformed into the global culture through Russian culture, although Ukrainian and Russian culture had perceived differently the importance of global processes. Big attention has been paid to the fact that free Ukrainian people had the experience of struggling for the affirmation of present national character, they did not want to form unions that would destroy freedom. The achievements of Ukrainian national freedom have been described primarily in the implementation of the “freedom” of the individual. Statements of the human freedom being the need of self-expression inside the individual freedom by means of obtaining a sign of social freedom have been suggested. It can be provided when collectivism has no pressure on the will of the individual and cannot influence its intellectual potential. The emphasis has been referred to the fact that the psychology of self-defense is based on Ukrainian cultural achievements being the part of its national identity. The forms of language development, the construction of temples, traditional rituals of rural life have been developed. The “live” power laid in national and cultural achievements of Ukrainians as they borrowed the values from other cultures and adapted to their minds. This happened due to the fact that national culture was formed as a specific element of the current world culture and withstand the pressure of “great power.” It has been noted that Ukrainians contributed to the development of Russian culture, they dissolved this so-called Little Russian mentality in the Russian public sphere and popularized Ukrainian spirit. The impact of ideas of European Slavophiles Decembrists, Ukrainian philosophers to the attitudes of Cyril and Methodius has been reviewed. Theoretical and methodological basis to analyze the maturing political identity formed work of contemporary philosophers, political scientists, cultural studies, where they were identified and developed fundamental categories methodology regarding patterns of political thinking Ukrainian nation.

Admission Dysfunctions of the lumbosacral spine are among the most common problems related to the movement of contemporary society throughout the world, and its incidence increases with age. In recent years, increased interest in the issues fascia, which until recently was neglected in the etiology of low back pain. One of the therapeutic options that can be applied in the case of chronic pain syndrome lumbar-sacral spine techniques are easing myofascial (ang. Myofascial release, MFR), which is one of the latest methods in the field of manual medicine. Objective of the work The aim of the work was overview AD recently published study on the effectiveness of techniques easing myofascial pain in chronic lumbar-sacral spine. Material and methods To find the current investigate research (publications of the last 5 years) dedicated to MFR in the treatment of chronic pain, lumbar-sacral spine searched the following databases: PubMed, PEDro (Physiotherapy Evidence Database), ScienceDirect and Academic Search Premier. The following keywords: myofascial release, myofascial release therapy, myofascial pain, chronic low back pain. Results 9 qualified to review the studies investigating the effect of loosening myofascial pain and range of motion, functional limitations, muscles, as well as the quality of life in people with chronic pain lumbosacral spine. Conclusions The results of this review show that there is little research on the MFR employs treat ailments low back pain lumbar - sacral. Based on the studies included in this review can be concluded that the MFR can be an effective treatment for back pain lumbar - sacral, but there is a need for further research with a well-developed research procedure that will allow the standardization of this therapeutic method.

Objectives This paper focuses on recognising and addressing the challenges of ADHD in early childhood girls. The paper aims to fill a gap in the scientific literature by focusing on the specificity of ADHD in girls, which differs from symptoms in boys. It also aims to raise awareness of the issue of ADHD among parents and teachers and to provide practical therapeutic guidance and educational support that is tailored to the needs of girls with ADHD. Material and methods The source materials for this publication will be various monographs and articles by special educators. The collected material will allow the analytical-critical method to synthetically realise the indicated aim of the work. Results Parents should learn to anticipate potential conflict situations, to exclude them or to plan in such a way that the child can cope with them. It is the parents' task to plan the day in such a way as to introduce a ritual and a daily routine of repetitive activities. Children with Attention Deficit Hyperactivity Disorder need to acquire skills to deal with conflict, emotional labile, anxiety and stress. Conclusions Often undiagnosed girls suffer alone together with their disorder. Close cooperation between parents and teachers is an indispensable element in the treatment of ADHD. A child with ADHD should be allowed to participate in the educational and educational process. It is important to get to know the peer group so that girls with ADHD can learn to recognise themselves and their own reactions and abilities.

This paper indicates significance of generational diversity management in modern business. Due to certain social, political and economic circumstances each generation is specific, with its own skills, interactions and expectations. What is common for all of them is the willingness to find the right employer. The one open to human needs and aware of their work commitment; the one to offer appropriate work surroundings, self- development and adequate gratification. The paper is aimed at presenting those generational disparities, for awareness of them is crucial in efficient human resources management. Worksite is the natural environment, where such age-related experiences and opinions clash, enabling to gain the right perspective and choose the most effective and innovative directing solution. Generationally diverse team brings multilevel benefits for both sites and aids enterprise development.

Objectives This paper aims to present a synthetic diagnostic tool for assessing wokeism in universities, offering a comprehensive framework derived from an extensive literature review. The purpose is to measure and evaluate the level and impact of wokeism, identifying strengths and weaknesses within university contexts. The framework development involves defining dimensions and indicators of wokeism, collecting and analyzing data through diverse sources like surveys and interviews, scoring and ranking wokeism levels. Material and methods This paper presents a synthetic diagnostic tool designed for the assessment of wokeism in universities. It extensively reviews literature on wokeism, offering a framework for the creation of this diagnostic tool. The provided examples demonstrate practical applications for measuring and evaluating the level and impact of wokeism within university settings. Results The paper highlights several limitations and implications that warrant consideration. First, the broad and general definition of wokeism employed might overlook nuanced variations within the movement. Second, reliance on secondary sources and hypothetical data raises concerns about the representation of the actual situation of wokeism in universities. Third, the subjective scoring and ranking system employed may lack the validity and reliability required for a comprehensive assessment. Conclusions The paper proposes directions for future research and practice. It recommends refining and operationalizing the definition and measurement of wokeism, testing and validating the tool and framework with primary and empirical data, and applying more objective and rigorous methods for scoring and ranking.

Objectives The issue of professional competence is dealt with by many scientific fields, hence the need to review the definition and classification of the concept and to indicate, based on the literature, the current state of research. The main objective of this paper was to identify the research gap in the area of the usefulness of competencies acquired during military service by Polish Army officers in their current workplace after military service. Material and methods The following research methods were used to write the paper: literature analysis and criticism, heuristic method and comparative method. The quantitative method was significantly applied in the work. A survey questionnaire was used, aimed at retired officers of the Polish Army regarding the use of their competencies after leaving the service. Results The terms that often accompany “competence” in theoretical considerations are qualifications and skills. However, qualifications and skills have a narrower context than competencies, which are the result of having both a wide variety of skills and qualifications. Most respondents found employment in a state institution and a uniformed organization. Retired officers pointed mainly to knowledge, experience, and some also to personality traits. Conclusions The issue of competence is undoubtedly an interdisciplinary concept, with its connotations in many fields of science. Consequently, the concept of competence is not clearly perceived in the literature. The personality traits that distinguish officers of the Polish Army are very valuable, as is their specialized knowledge. They will certainly be a great asset to a retired officer's future employer.

Objectives The purpose of the paper is to examine the impact of labour incomes on economic activity and growth in Poland. Material and methods The thesis of the paper is rooted in the hypothesis of underconsumption and it claims that a proportion of labour incomes to the domestic product exerts an influence on the structure and the value of the aggregate demand and thus it eventually has an effect on economic activity. Empirical analysis provided refers to macroeconomic data for the period 2010-2019. Results The results support the thesis; relatively low growth of labour incomes is followed by low rates of economic growth and investment and higher rates of unemployment. Conclusions The analysis of changes in real production per employee, real wages, the rate of unemployment, the rate of GDP growth and changes in households’ consumption spending strongly support the claim that low wages at least periodically stand behind a demand constraint in the Polish economy and that they impair economic results.

Introduction The rising prevalence of electronic cigarette (e-cigarette) use has prompted concerns regarding its potential health implications. While much attention has focused on respiratory and cardiovascular effects, injuries, oral trauma, and bone fractures linked to e-cigarette use have received less scrutiny. This paper aims to comprehensively review the landscape of injuries, oral trauma, and bone fractures induced by e-cigarettes, shedding light on this underexplored facet of e-cigarette-related harm. Material and Methods This literature review has analyzed 16 papers. Inclusion criteria: researches and case reports published after 2015. PubMed and Google Scholar has been searched to identify the papers. Analysis of the Literature Existing literature suggests a growing incidence of injuries, oral trauma, and bone fractures associated with e-cigarette use, albeit with limited systematic investigation. Mechanisms underlying these injuries range from device malfunctions to inadvertent impacts during use. Case reports highlight a spectrum of injuries, including oral burns, dental trauma, and skeletal fractures, often involving the face and mouth regions. Conclusions Despite the lack of comprehensive epidemiological data emerging evidence underscores the need for heightened awareness and preventive measures to mitigate e-cigarette-related injuries. Enhanced education, regulation of e-cigarette devices, and promotion of safer usage practices are crucial steps towards reducing the burden of e-cigarette-related harm on oral and skeletal health.

The paper proposes a modern approach to the automated design of three-dimensional models of wood drying chambers and the study of their operation parameters using the SolidWorks Simulation tool, which makes it possible to create various information models using computer tools. Therefore, in this paper, a three-dimensional model of a wood drying chamber was developed and presented, which includes its main components: walls, ceilings, door, stacks of lumber to be dried, a fresh air supply system, a system for its circulation through fans and heating through heaters. For the automated design of three-dimensional models of all these components, the corresponding algorithms were also developed and programmatically implemented using a specialized SolidWorks application programming interface. At the same time, the developed software application takes into account the parameters entered by the user, including the size, quantity, and type of lumber to be dried. In addition, several thermal calculations were performed across the stack, including with different air velocities. This allows us to analyze the effect of this speed on the distribution of heat transfer across the stack. In general, the obtained results are automatically displayed in one of the windows of the software application. This approach makes it possible to obtain results in the background of SolidWorks with minimal user intervention. Despite the fact that such studies are carried out in SolidWorks Simulation, the graphical results, including the temperature distribution across the stack, are fully automated without user intervention. The software application also makes it possible to automatically change the geometry of a three-dimensional model of a wood drying chamber or stacks within specified limits. In turn, the use of the developed software application in combination with SolidWorks Simulation can effectively speed up the process of creating three-dimensional models of wood drying chambers and studying their operation parameters. In general, this work reflects the trend towards digital transformation in industry, opening up new opportunities for woodworking enterprises and contributing to their market competitiveness and production efficiency.

Introduction and purpose Non-specific and specific lower back pain syndrome is one of the leading causes of musculoskeletal disability and affects more than half of the population worldwide. The aim of this paper is to confront the problem of lumbar pain, possible diagnostic options, conservative and surgical opportunities with long term satisfactory rate. State of knowledge The paper reviews literature on lower back pain syndrome, sciatica, radiculopathy and lumbar disc herniation in regards to detection of the problem, classifying it and possible methods of resolvement. The WHO defines lower back pain as one of the leading causes of musculoskeletal dysfunction and it focuses on reducing the occurrence by programs like WHO Rehabilitation 2030 Initiative, UN Decade of Healthy Ageing and others. The paper also focuses on non surgical options of treatment. Material and method A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on differential diagnosis depending on clinical presentation and possible treatment methods depending on symptoms, pathogenesis of the disorder and available procedures. Summary Our review managed to present the current state of development, possible differential diagnosis, prevalence of neural compressions, sciatica and radiculopathy in different diagnostic options. By receiving multiple studies we confront varied opinions of specialists regarding the approach to lower back pain syndrome and favorable forms of care. Additionally we came to the conclusion that the difference of patients' long term satisfactory rate in regards to nonoperative and operative treatment is not significant, and flattens over the years.

Gilbert’s syndrome is the most common inherited jaundice worldwide. It affects 5-10% of the population. It is caused by a mutation of the UGT1A1 gene, which results in impaired bilirubin metabolism. It is a benign disease and does not affect the life expectancy of patients. Patients with Gilbert’s syndrome should be alert to factors that exacerbate the course of the disease, interactions with medications taken and possible comorbidities such as hemolytic anemia, cholelithiasis or schizophrenia. However, it is the responsibility of physicians with such patients under their care to properly educate patients. Gilbert’s syndrome carries not only the consequences associated with the mutation, but also has many benefits that patients may not be fully aware of. Mildly elevated bilirubin levels have an antioxidant and anti-inflammatory effect, which prevents the development of lifestyle diseases and cancer. Ongoing clinical trials suggest that this could be a great step toward new treatments for diseases affecting the entire human population. PURPOSE OF THE WORK: This review paper aims to show Gilbert’s syndrome as a multifaceted disease and to sensitize doctors' attention to patients with the described mutation. MATERIALS AND METHODS: An analysis of papers available in PubMed and Google Scholar was performed using the following key words: Gilbert’s syndrome, bilirubin, UDP-glucuronosyltransferase, Gilbert’s syndrome harmful and protective aspects, iatrogenic Gilbert’s syndrome RESULTS: The result of the work is to present Gilbert’s syndrome as a disease that carries medical problems directly related to the mutation, but also, in some cases, has a protective effect on affected individuals. The work highlights the complexity of the problem.

Introduction and purpose: Diabetes has emerged as a global lifestyle disease, with an alarming rise in cases, particularly of type 2 diabetes. In Poland, over 3 million people are diagnosed, and an estimated 4 million cases are expected by 2030. Effective treatment involves a multifaceted approach, including dietary intervention, physical activity, and pharmacological options. Incretins, such as glucagon-like peptide-1 (GLP-1), play a pivotal role in carbohydrate metabolism regulation, and GLP-1 analogs have become essential in managing type 2 diabetes. This paper explores the development and mechanisms of GLP-1 analogs, detailing their impact on insulin secretion, gastric emptying, and weight reduction. Description of the state knowledge: Various GLP-1 receptor agonists, including exenatide, liraglutide, dulaglutide, semaglutide, and the novel tirzepatide, are discussed. These drugs exhibit diverse pharmacokinetics, modes of administration, and effects on glucose metabolism and weight. Despite their efficacy, there is a concerning trend of off-label use, particularly for obesity treatment, leading to shortages for patients with valid prescriptions. This misuse is fueled by para-advertising on social media platforms, contributing to a surge in prescriptions and reimbursement costs. To address this, guidelines for GLP-1 analog use in obesity treatment are proposed, emphasizing the need for a stable drug supply and normalizing drug availability. Summary: In 2023, concerns intensified with reports of counterfeit GLP-1 analogs, prompting regulatory interventions. The paper concludes by underscoring the critical role GLP-1 analogs play in diabetes and obesity treatment, while emphasizing the importance of responsible prescription practices, guidelines adherence, and regulatory vigilance to ensure patient safety and mitigate the risks associated with misuse and counterfeit drugs.

Effective body posture entails the correct alignment of body parts in relation to each other and is crucial for preserving balance, stability, and the efficient operation of muscles and joints. The major types of posture abnormalities such as lordosis, kyphosis and scoliosis can lead to alterations in various areas of the body, such as stomatognatic system. The potential correlation between malocclusion and body posture remains a subject of controversy. The aim of this review is to investigate and evaluate the association between posture defects and malocclusion on the basis of literature. This literature review has analyzed 18 studies. Inclusion criteria: clinical researches published after 2010, regarding children and adults. PubMed and Google Scholar has been searched to identify the papers. In 18 analyzed studies, 2133 patients were enrolled (including 979 children aged 4-18). A positive correlation between scoliosis and different types of malocclusion has been proven by six papers. There are also other noteworthy dependencies, such as overjet and pelvic torsion, kyphosis and sagittal position of mandible, skeletal Class III and torticollis, cross bite and scapula plane. Adolescent Idiopathic Scoliosis significantly affects the stomatognathic system, leading to issues like crossbite, crowding, increased overjet, overbite, partial open bite, and midline deviation. Orthopedists should collaborate with orthodontists for comprehensive treatment, particularly during developmental stages.

This scientific paper focuses on the treatment of breast cancer, one of the most common cancers among women. Despite increased awareness and the popularity of screening tests, statistics indicate a significant rise in incidence. The paper presents breast-conserving treatment methods, including brachytherapy, as a modern technique with promising outcomes. It describes the physical properties of ionizing radiation used in brachytherapy, discussing the photoelectric effect, Compton effect, and the phenomenon of pair production. The paper then delves into the biological effects of ionizing radiation, emphasizing the dependence on the cell cycle phase. It highlights lethal, sublethal, and potentially lethal cellular damage, categorizing the effects of radiation interaction into early and late responses. The discussion transitions to the application of brachytherapy in breast cancer treatment, focusing on various techniques such as LDR, PDR, and HDR. The paper provides a detailed description of brachytherapy's use in breast-conserving treatment, considering contraindications, treatment planning, and Accelerated Partial Breast Irradiation (APBI) techniques. The radioisotopes used in brachytherapy are also presented, with special attention to Iridium-192. The physical and practical aspects related to this isotope are discussed, along with other commonly used radioisotopes such as Cesium-137, Cobalt-60, and Strontium-90. The paper concludes with a summary, emphasizing the significance of brachytherapy in breast cancer treatment and outlining its prospects for development. The authors highlight precision and shortened therapy duration.

Introduction and purpose: In our work, we focused on presenting the role of collagen supplementation and its impact on skin and joint health. We considered studies discussing the differences in the effects of collagen from various plant and animal sources. We also examined the influence of the degree of hydrolysis on the absorbability of the supplement. The aim of the paper is to comprehensively summarize knowledge on collagen supplementation, differentiating between its sources and forms. Material and methods: In our paper, we endeavored to address the subject of oral collagen supplementation comprehensively. We explored studies about various forms and sources of collagen. We also delved into the collagen supplementation impact on skin and joints health and impact of additives in enhancing the positive effect of collagen . State of knowledge: Oral collagen supplementation can be beneficial for skin and joints health. It promote collagen synthesis in human body increasing strength of skin and joints. The higher the degree of collagen hydrolysis, the more easily it is absorbed by the body. Additives in the form of vitamin C and A can enhance collagen synthesis. Results and conclusions: This review article indicates a growing interest in oral collagen supplementation and its impact on health. Although there are encouraging findings regarding positive effects, further research is necessary to better understand and determine the optimal conditions for achieving maximum supplementation benefits. This information may be crucial for clinical decisions made by physicians regarding joint reinforcement and anti-aging effects on the skin.

Introduction and purpose The term "probiotic" rooted in Latin, signifies 'for life,' reflecting the historical use of fermented products for therapeutic purposes. While browsing many websites devoted to healthy eating or popular science topics, we often came across the topic of probiotic food without any confirmation by scientific research. The aim of this paper is to confirm or exclude the presence of probiotics in popular foods. State of knowledge The paper reviews literature on the health benefits of various food that is traditionally considered probiotic, focusing on how they impact on varied health conditions. Defined by the WHO as living microorganisms conferring health benefits when consumed adequately, probiotics, mainly bacteria from Lactobacillus and Bifidobacterium genera, play a vital role in maintaining gut microbiota balance, regulating digestion, supporting the immune system and influencing mental and cardiovascular health. In addition, the paper also searches for scientific basis for their action. Material and methods A review of the literature available in the “PubMed” and Google Schoolar was conducted. We focused on checking whether the microorganisms contained in pickled food meet the WHO criteria for probiotics. Summary Our review managed to prove the probiotic effect of almost all presented food, except for miso. By reviewing many articles, we shed a lot of uncertainty on the repeated myth about the lack of probiotic effect of cucumbers preserved in vinegar and what is more, we found scientific assumptions about the probiotic effect of vinegar itself. Fermented food contains numerous strains of bacteria that are resistant to acid, bile and temperature in the human digestive tract and can be effectively used as a source of probiotics. Additionally, compared to probiotics from the pharmacy, fermented products provide not only probiotics, but also nutritional value, valuable fiber and vitamins, benefiting to our health.

Introduction and purpose: The purpose of this scientific paper is to review the current knowledge of the effects of red wine on human health, particularly with regard to cardiovascular disease. State of Knowledge: Since the 1990s, red wine has gained its status as a health-promoting alcohol through the French Paradox - when drunk in moderate amounts, it protects against cardiovascular disease. The authors have collected scientific papers on the health effects of alcohol, red wine and resveratrol-a polyphenol that is the main component with health-promoting effects of wine. On their basis, they analyzed the assumptions of the positive effects of wine reaching inconclusive conclusions. Summary: Despite the fact that both ethanol and resveratrol have a positive effect in in vitro studies, in population studies their effect is much less significant, either because the negative behavioral-health effects in the case of ethanol are omitted or the actual effective doses of resveratrol are omitted.

Context: Angular gyrus is an anatomical structure of the brain located in the parietal lobe, taking part in writing and reading, language-use, memory and attention and spatial recognition. It is supplied by the angular gyrus artery, which is one of the caudal branches of the middle cerebral artery. One of the clinical pathologies of the angular gyrus artery is the ischemic stroke of the angular gyrus in the dominant hemisphere, responsible for the presence of Gerstmann Syndrome: left-right disorientation, agraphia, alexia, acalculia and finger agnosia. This systematic review aims to present the variety of anomalies of the main cerebral artery and the angular gyrus artery. Objective: Preparing a systematic review of papers describing the course anomalies of the angular gyrus artery. Materials and methods: PubMed and Google Scholar electronic databases was searched for phrases: ‘Angular gyrus artery’, ‘Artery of angular gyrus’, ‘Middle cerebral artery branches’, ‘Branches of middle cerebral artery’, ‘Gerstmann Syndrome’ published between years 2015 and 2023. Also 3 papers published before 2000 were used. From the selected 30 papers, 6 were used to prepare this analysis. Results: The middle cerebral artery, from which arises the angular gyrus artery, is marked by a significant variety of its division, mainly the number of the dividing trunks of the artery. Depending on the type of the division, the angular gyrus artery can arise from the upper, middle or lower trunk and vary in sizes. It can also appear as a singular or two separate branches. Instances of the anomaly of both the angular gyrus artery and posterior parietal artery are rare, but reported. Conclusions: The angular gyrus artery is characterised by a number of anomalies in its course, separation from the middle cerebral artery, diameter and branching.

Introduction and purpose: Apples are a widely consumed fruit globally and are known to be a great source of nutrition. Studies have shown that apples contain high levels of antioxidants, dietary fiber, and vitamins that contribute to numerous health benefits. This paper aims to provide a comprehensive review of the impact of apples on human health. State of knowledge: The paper reviews the current literature on the health benefits of apples, focusing on their impact on various health conditions such as cancer, cardiovascular diseases, diabetes, and obesity. Additionally, it examines the role of apples in improving intestinal, immune, and cognitive function. The paper also discusses the potential mechanisms by which apples exert their health benefits, such as high levels of flavonoids, polyphenols, and dietary fiber. Summary: In conclusion, the vast body of evidence reviewed in this paper supports the notion that consuming apples regularly can contribute to better health outcomes. They may help reduce the risk of chronic diseases, such as cancer, cardiovascular diseases, and diabetes, as well as promote healthy gut microbiota and immune function. Despite the controversy surrounding the use of pesticides in apple cultivation, the benefits of consuming apples outweigh the risks. Therefore, it is highly recommended to include apples as part of a balanced and nutritious diet to promote optimal health and wellbeing. As the saying goes, "An apple a day keeps the doctor away".

Introduction and aim Diabetic foot ulcer (DFU) is a chronic condition that affects an increasing number of people each year[1]. Healing the ulceration requires cooperation between patients, specialists and scientists in order to achieve satisfactory results. Treating this type of wound is not only a therapeutic challenge[1,2,3,4,5,6], but also an economic one, which is why so much scientific research has already been made on this phenomenon[2,3]. Still scientists continue their quest for new cost-effective alternatives to current therapeutic options that would be consistent with contemporary knowledge and available engineering capabilities in pursuance of creating techniques and new dressings that will accelerate the healing of DFUs[2,3,7,8]. Factors such as stress, obesity, certain medications, and chronic diseases appear to negatively affect the process of repair [1,9,10,4,6,11]. Studies prove that aloe vera gel due to its healing properties, can be considered as a potential dressing that will expedite the mending process of diabetic foot ulceration[12,13,14]. In this paper, we performed a literature review of the applicability of aloe vera in the healing process of DFUs. Materials and methods Searching the available literature, including randomized clinical trials and systematic reviews, we drew on databases focusing on the effects of treatment for diabetic foot ulceration using Aloe vera. Conclusion: The current scientific research on the use of Aloe vera gel in diabetic foot ulcer treatment indicates that this method is safe, effective and inexpensive[2,3]. However the difficulty of treatment and the increasing prevalence of this type of wound pose a challenge to finding new solutions and exploring mechanisms in which aloe vera can have a possible role in the wound healing process. Nevertheless, this paper presents a promising impact of Aloe vera gel applicability in the healing process of diabetic foot ulcer.

Introduction and purpose: Currently, as the frequency of obesity is alarming, the role of many factors that could contribute in preventing and treating this condition are being researched, among them the certain food with beneficial health profiles - one of them is soybeans, specifically the isoflavones it contains. Populations that consume soy are known for lower risk of various disorders - among them obesity. The aim of this paper is to summarize the existing paper about the role of these bioactive components in the treatment of this condition. The search was conducted using PubMed and Google Scholarship databases. Brief description of the state of knowledge: Obesity is one of the leading challenges in today’s healthcare as it leads to various chronic diseases that are fraught in consequences. Current knowledge is pointing into the association between composition of the soy isoflavones and the lower risk of obesity. Results of the studies indicate that patients affected with obesity could benefit from introducing soy isoflavones into their diet along with other necessary modifications. Conclusions: Soy isoflavones are potential agents in the holistic obesity treatment. Consumption of isoflavones merits further recognition as foregoing results of conducted studies are pointing to its possibly meaningful role. It is worth mentioning that consumption of soy isoflavones is not only an anti-obese factor, but also presents various other health benefits and when consumed rationally poses no risk to human’s well being. We conclude that further studies would enable us to fully reveal the potential of those polyphenols.

This article examines the concept of integrated sustainability management and its relationship with corporate social responsibility (CSR) and environmental, social and corporate governance (ESG). Although CSR is a normative concept that requires companies to be responsible for their participation in society from an ethical perspective, ESG helps measure and quantify these efforts, primarily through investment criteria. The paper identifies that sustainability reporting (SDR) can bring financial, reputational, risk management and strategic benefits to companies, and more companies recognize the importance of sustainability reporting and making it a priority in their business practices. This study presented grouped classifications of the benefits of ESG disclosure in corporate reporting. The main problems faced by Ukrainian companies during the implementation of ESG criteria in their activities are highlighted, in particular: limited awareness and lack of understanding of ESG issues, lack of standardized ESG reporting, improper disclosure of ESG information, weak compliance with existing regulations, insufficient coverage of ESG issues in mass media information, etc. This article also suggests some measures that should be taken to solve the mentioned problems. The paper highlights the relationship between sustainability and financial performance, a widely debated topic. Some argue that implementing sustainability practices can have a positive impact on a company's financial performance in the long term, while others argue that sustainability practices can have a negative short-term impact on financial performance. In addition, the analysis of major meta-reviews that analyze and summarize research findings on the relationship between ESG reporting and financial performance is highlighted. These meta-reviews show that there is indeed a positive relationship between these metrics, although the strength of the relationship may vary depending on a number of factors, including industry, geographic location, and company size.

Objectives The main objectives of this paper are to define the issues related to a search for a drowned corpse, fishing it out and procedures to take evidence when the victim’s body has not been found. Material and methods A case analysis was performed in which the criminal covered up traces by drowning the corpse. An extensive study in this regard was conducted covering 500 criminal cases concluded with a final and binding judgement. Finding a corpse in a lake 24 years after the crime is a case described in detail in this paper. The authors obtained the consent of the District Prosecutor and the District Court in Olsztyn for publishing the case materials. Results Neither the process of the corpse search nor fishing it out were carried out properly in the case under study. The large number of search attempts was caused by poor coordination of the search groups and by using unsuitable tools. Most methods were ineffective given the small size of the package resting on the water reservoir bed. Conclusions A search for a drowned corpse requires good cooperation between the search team and law enforcement authorities and later with forensic medicine specialists in establishing the cause of death.

Objectives This paper is about to review some key weakness of the Solow model, when it is applied to less developed economics. Material and methods The paper takes the economic data performance for the Chilean economy from1990-2020, focusing in GDP growth, as well as the investment trend given the positive correlation between these variables. A theoretical background of the Solow Model is analyzed in more details, as well as its assumptions , especially those ones : a. Which assumes that production decisions are self-made by the operation efficiency requirement, b. Which make of the supply of labor high elasticity, linked to population growth , a key variable to ensure that given technological progress, output may growth as expected in the C-D production function. c. The role of technological progress in productivity growth given that in a less developed economy, productivity gains, would hardly come up without government support by setting rules and policies dealing with property rights, efficient regulation, tax incentives, and stable economic policies. Results a. The implication of lacking a management variable, meant that the economy would be on its own, far from being capable of coping with all the requirements to sustain economic growth path. b. The Solow Model standard formulation, had important limitations for a less developed economy c. Investment pattern follow a two tier format: „investment creation” and “investment deviation”. Conclusions The evaluation about the Chilean economy outcome up to 2019, was based on the advantages and disadvantages of the neo liberal model principles, without taking into consideration the ill designed microeconomic setting provided by the Solow model to sustain the path of key variables (Economic growth), as an input for public policies design and its right timing and consistency

The paper is dedicated to the Western reception of Narod na vojne (People at war) written by the little-known Russian writer Sof'ja Fedorčenko. Although it was published first as supposedly authentic reports of soldiers (1917, Kiev), Fedorčenko later claimed it to be one of her own artificial works. This paper focuses on a comparative analysis of three translations of Narod na vojne and transformations, which take place by means of the paratexts and the reorganisation of the fragmentary text. The English translation Ivan speaks (1919, Boston) emphasize an anti-war message, the German translation Der Russe redet (1922, Munich) accentuates a supposed ‘Russian character’ and the French one Le peuple à la guerre (1930, Paris) directs attention to the Russian Revolution.

Objectives The phenomenon of food terrorism belongs to one of the many varieties of terrorism and, due to its effects on society, is one of the most dangerous manifestations of criminal activity. As a result of food terrorism, food safety and food security are threatened. The purpose of this paper is to present the general essence of the phenomenon of food terrorism and to identify the requirements of existing systems from the field of management to minimize the consequences associated with it. The rationale for dealing with this topic is the current unstable economic and political situation, especially the ongoing war in Ukraine, prompting organizations to be more concerned than before about the safety of the product, consumers, and their employees. Material and methods Critical analysis of the literature, the method of document analysis, including the legal-dogmatic method, then the comparative method, as well as the method of synthesis, and logical inference. Results The paper presents the results of the analysis of existing recognized quality and food safety management systems. The systems were analyzed for their alignment with food defense requirements. Conclusions The research confirmed that each of the identified systems contains references to food defense, although not all contain a clear definition of it, a need to develop a defense plan, and conduct a risk assessment. The management systems are generic, which means that organizations should use additional solutions, such as the TACCP (Threat Assessment Critical Control Points) system when implementing a food defense plan.

Objectives Innovation, especially eco-innovation (eco-innovation), is an important element of modern economic systems. The aim of this paper is to assess resource efficiency indicators considering them from the perspective of the level of eco-innovation in EU countries. Material and methods Based on an analysis of the available literature, the paper focuses on the issues of measuring eco-innovation. The article, based on the analysis of the available literature on the subject, focuses on the issues of measuring eco-innovation. Then, the available eco-innovation indicators were used and statistical data for 2021 were analysed. Data was collected from European Commission reports. Results The analysis of selected indicators was presented both for Poland and for the other EU countries, which made international comparisons possible. Then, through the so-called indicator monitoring, the stage of development of eco-innovation was determined for each country Conclusions The eco-innovation indicator is one of the most important indicators in the field of environmental protection. The implementation of eco-innovation is therefore aimed at stimulating sustainable development.

Introduction. This paper studies the role of the monetary policy in the economy of the state, as one of the main instruments to support it’s financial potential, both at the period of military conflict as well as in the period of recovery after it. Methodological bases are general and special methods of scientific research, including synthesis, analysis, modeling, comparison, etc. The main information sources were the resources of World Bank Open Data, the data of National Bank of Ukraine and state statistics service of Ukraine. Purpose. The main purpose of this paper is to study and analyse macroeconomic methods and instruments, which were used by different countries in the post-conflict recovery period and theoretical implementation of using these instruments in Ukrainian reality. Results: The strategy of synchronizing the actions of the central bank and the government must be adjusted according to the peculiarities of post-conflict economic recovery of each country separately. The studies of macroeconomic indicators of countries, that successfully overcame the consequences of military actions show the main role of the central bank in stimulating economic growth of the country. Conclusions: To further solve the problem of post-conflict recovery of state's economy, the perspective direction would be to build effective strategies of cooperation for the institutes, that perform monetary and fiscal policies, that would have a direct impact on the effectiveness of economic growth and the development of national security of the country.

This paper examines how Kharms uses performativity in his 1928 play Elizaveta Bam to explore the relationship between the subject and the state. The play follows Elizaveta as she attempts to escape a murder charge by cycling through a series of radically different and strange personae. Her many transformations obfuscate her actual identity and personality; in the context of her flight from men who would kill her, this ability to transform is a survival mechanism. Ultimately, however, she is caught, and Kharms frames this as an inevitability. This approach to the relationship between state and subject corresponds to Althusser’s concept of interpellation, which tracks the deep connection between individuals and the ideologies that surround them. This paper argues that Kharms makes the actor’s performance into the central device of the play, and in so doing, he uses the tools of theater itself to depict (futile) resistance to overwhelming state power.

The avant-garde literary group OBĖRIU, with its poetics of the absurd, alogism and grotesque, had a great influence on later Soviet Russian literature and on neo-avant-garde movements as well. This paper investigates the connection between OBĖRIU and the neo-avant-garde of the 1970s and 1980s, especially by comparing two representatives of these different ‘ages’ of avant-garde – Daniil Kharms and Dmitrii Prigov. The analysis will focus particularly on the genre of the anecdote, with which they both experimented. After tracing the heritage of OBĖRIU poetics in Conceptualism and in the work of Prigov, who was interested in the form of Kharmsian prose miniatures, the paper will compare the well-known Anecdotes from the Life of Pushkin by Kharms (1937) with a series of quasi-hagiographical texts, Stories about Stalin, by Prigov (1975-1989). These bizarre sketches have several common features related to the genre, the formal structure, and the stylistic devices employed. Despite some striking parallels, however, the analysis will demonstrate that Kharms and Prigov have two different approaches to understanding deconstruction of myths, the grotesque, and the absurd.

The essay attempts to outline the issues of the visual culture of the selfie from the perspective of “visual identity” that has referred to contemporary art. In this paper, I analyze examples of the following artworks: The Reincarnation of Saint ORLAN by the French artist ORLAN, the Bodies© INCorporated website, designed by Victoria Vesna, The Little Revenge from the Periphery by José Bedia Valdés, The Chief: He Who Sold Africa to the Colonists and Autoportraits by Samuel Fosso. In addition, this paper is focused on an analysis of the “biopower” concept which refers to Michel Foucault’s “docile bodies.” This concept is based on the neoliberal power process over the production of living beings and exercising control over them is an updating of the development of political, democratic, and economic institutions, as well as information and biocybernetic technologies. The “docile bodies” concept strengthens the conviction of the bodies must become the object of biopower interventions for the “perfect body” concept to act upon the strictly defined appearance of the body consistent with the standards and norms of “beauty” adopted by visual culture. In this situation, the selfie and photographic images produce homogeneous images, which function as “ideological texts” making our “visual identity” and self-image. This concept is given a lot of considerable space in this paper because the selfie can be regarded as an “personality identity” shaping the visual appearance of our bodies. In the essay’s conclusion, I claim that the visual culture of the selfie seems to be an aesthetic phenomenon shaped by a visual medium such as digital photography. However, photography does not is the key medium of the selfie. My analyses were aimed at showing that this role plays an “image,” no matter how it can be understood.

Introduction and purpose of the work. Aesthetic medicine currently has many methods to keep our skin in the best possible condition, and one of these methods is the use of tissue stimulators. The purpose of the following paper is to analyze, present and apply tissue stimulators in anti-aging prevention. Review methods. The paper is based on a review of literature about tissue stimulators, aesthetic medicine and anti-aging therapy. Most of the publications used were from Pubmed and Google Scholar electronic databases. State of the art description. Aesthetic medicine is a department that over the past few years has been closely associated with the slowing down of skin aging processes. In humans, over the years, proliferative processes slow down, the rate of collagen and elastin degradation increases, and the intercellular matrix is reduced. Substances known as tissue stimulators used in anti-aging therapies mean that the above processes can be delayed. Conclusion. The expectations of patients visiting aesthetic medicine clinics regarding activities that improve their appearance are increasing. They are unable to accept their own aesthetic defects, which is why they often strive for unnatural effects. Tissue simulator treatments can be a valuable way for patients to maintain healthy and rejuvenated skin.

Introduction: Xenotransplantology, the field of transplantation involving organs or tissues between different species, holds great promise for addressing the global organ shortage crisis. However, the development of new technologies without proper legislative preparation raises significant moral and ethical considerations. This paper provides an overview of the current state of xenotransplantology, highlighting its revolutionary potential alongside the moral dilemmas it entails. Aim of the study: The aim of this study is to assess current social, ethical, religious, and legal trends regarding the issue of xenotransplantation. Materials and methods: To obtain up-to-date information concerning trends in xenotransplantation, a review of the PubMed and Google Scholar databases, along with the latest legislative reports in both Europe and Poland, was performed. Conclusions: Firstly, the authors briefly report on the current situation concerning transplantology and the widely spread organ donor crisis. Next, the issue of species boundaries and the moral status of non-human animals is addressed. The assessment of ethical implications of utilizing animals as organ donors is examined, along with the legal acts regulating this issue. Moreover, the authors attempt to evaluate the cultural and religious differences related to this concern. Furthermore, this study discusses the allocation and distribution of xenotransplants, considering issues of justice, fairness, and access to this innovative medical technology. Lastly, the paper delves into the risks and uncertainties associated with xenotransplantation, including the possibility of cross-species disease transmission and intensified course of organ rejection disease.

Introduction and Purpose: Coeliac disease is an increasingly prevalent disorder worldwide. It is estimated to affect about 1% of the population and its symptoms heavily impact people's lives. The aim of this paper is to delve into the topic of coeliac disease and present basic information about its origins, current diagnostic methods, and the challenges associated with its treatment. This article includes all the necessary information from up-to-date sources. State of Knowledge: Coeliac disease was discovered a long time ago, but it is still not completely understood. Every year, new research is published regarding different populations in various countries. While we know more about the disease, its symptoms, and causes, we are still far from fully understanding all the inflammatory processes occurring in the human body. There is solid evidence that this enteropathy is caused by gluten, and the only way to reduce the clinical manifestation of coeliac disease is to adhere to a gluten-free diet. However, some patients do not benefit from this type of diet and still suffer from coeliac disease. New drugs currently being developed offer hope for these individuals, as they attempt to target the immunological reaction and mitigate the immune response in the small intestine. Conclusion: As approximately 1% of the population suffers from this disease, it is crucial to diagnose patients in the early stages of its development. Early diagnosis can prevent the development of other disorders that coexist with coeliac disease, which can be particularly dangerous, especially for children. This paper provides up-to-date information about the clinical manifestations of the disease, as well as methods of diagnosis.

This article focuses on the promotional aspects related to the tourist attractiveness of the neighboring countries-Poland and Slovakia. The purpose of the article is to analyze the issue in question and point out the importance of the search for ways to increase the effectiveness of management of the area of tourism promotion in both countries. The authors used an empirical research method with quantitative-statistical and qualitative studies on specific promotional campaigns. The Olympic Games have the greatest marketing potential among sporting events, as the most important sporting event in the world. The possibility of organizing such an event in Poland and Slovakia would certainly serve to improve the recognition rates of both countries. The authors will try to demonstrate this potential as part of the considerations in this article. Acknowledgement: This paper was supported by the project NP-KSV-ET-01-2023-12/ST - International cooperation in the field of development, management and law in tourism and sports between the Republic of Poland and Slovak Republic. The views expressed in this paper are those of the authors and should not be taken as reflecting the position of any authority, entity or institution. This article presents the legal status as of 25 March 2023.

Objectives A number of studies have dealt with the effects of economic integration on foreign direct investment, however without a comprehensive and simultaneous analysis of the overall positioning of these countries along the investment development path (IDP). In the current paper, a comparative analysis is conducted of IDPs of four Eastern European countries, both members and non-members of the European Union. The purpose of the paper is to determine the effect of economic integration on foreign direct investment (FDI) flows and on the movement of these Eastern European economies through their IDP stages. Material and methods An attempt is made to identify the positioning of the sample countries on the IDP, using trend estimation depicting the relationship between net outward investment (NOI) position per capita and gross domestic product (GDP) per capita, as well as detailed descriptive data on inward and outward FDI stocks and flows, subsequently supported with econometric analyses. Results While the findings point to a rather ambiguous effect of European Union (EU) membership on FDI growth and IDP trajectories, integration tends to exert a stronger effect on outward FDI than on inward FDI of member countries. Conclusions The study’s findings reveal the need to add new theoretical considerations to the interface between economic integration and the IDP model as well as formulate certain policy implications resulting therefrom.

Objectives The paper is of a cognitive nature, it aims at diagnosing the factors of activity of the elderly and defining their anxieties and expectations related to old age and ageing. Material and methods The paper is a set of theoretical deliberations consistent with the literature of the subject and empirical deliberations collected based on generally available statistical data and own research findings. The presented research is of an exploratory nature. Results The more and more visible process of ageing societies is contributing to the growing interest in the problem of old age, particularly with regard to the social perception of old age itself and to the related complex process of ageing. This paper attempts to analyse the indicated aspects, considering seniors' attitudes towards the discussed problems. The article presents statistical data for Poland and the author's own research findings. Conclusions Contemporary old age is really varied in terms of age, sex, education level, and first of all in terms of health and independence level, thus, the way of experiencing it is very individual. However, one can indicate some trends and tendencies which accompany this process. At present, seniors prepare better and better to go through old age, more and more often they take advantage of various forms of activity, owing to which they can face the consequences of aging and experience their old age more and more consciously.

Oral mucosa is an inner lining of oral cavity, which maintains different functions including protection of epithelial integrity. Pathology of oral mucosa can develop in response to the action of pathogenic microorganisms, viruses, and various traumatic factors; it can be a result of systemic pathology of a patient as well. Pain and discomfort usually accompanies such conditions leading to decrease of patient wellbeing. The basis of the pharmacological regulation of the regeneration process is the stimulation of wound healing. The aim is to summarize and discuss the spectrum of remedy options that are used to stimulate epithelization of oral mucosa. The overall goal of the paper is to provide full and comprehensive information for dentists and their patients about medicament variety, ways of theirs application and dosage. Methods. Relevant literature from MEDLINE (PubMed), Google Scholar, and in open access journals which are published by Elsevier was selected using the following key words «oral mucosa», «epithelization», and «remedy» were used in various combinations by the year of 2023. In total there were found 48 papers. To the selected scientific papers we applied the inclusion and exclusion criteria to choose the relevant ones. Conclusions. A significant number of drugs for the treatment of inflammatory processes in the oral cavity are available nowadays on dental market. Numerous studies substantiates the effectiveness of their use in dentistry. Therefore, when choosing pharmacological drugs, preference is given to drugs with a complex effect, which locally affect various links of the pathogenetic mechanism of the occurrence of diseases and do not disturb human wellbeing.

Endometriosis is a chronic gynaecological disease characterized by the presence of the uterine mucosa that functions in accordance with the menstrual cycle outside of its usual location. This disease significantly reduces the quality of life of women facing numerous ailments, most often pain, and may lead to reduced fertility. The prevalence of endometriosis is difficult to determine due to the complexity and lengthy diagnosis. It is estimated that this disease occurs in 3-8% of women of reproductive age, and symptoms may also appear after menopause. It is worth noting that the relationship between the disease's severity and endometriosis symptoms is often not proportional. The aim of the paper is to present a case report of a 23-year-old female patient with endometriosis, to differentiate the disease from irritable bowel syndrome and to draw attention to the problematic and lengthy diagnostic process due to the multitude of symptoms from various organs. Material and method: Study of an individual case of a patient and a review of scientific articles available in Google Scholar and a review of publicly available textbooks in the field of medicine. The paper emphasizes the need to broaden the knowledge about endometriosis by specialists in many fields of medicine and points to the lack of quick, minimally invasive tests enabling efficient diagnosis of the disease. Increasing the awareness of doctors including other specializations than gynaecology, organizing campaigns to increase awareness of the disease among women, which may contribute to earlier diagnosis of patients, earlier application of an effective treatment, and improvement of patients' quality of life.

Introduction:Lipid disorders are one of the most common modifiable risk factors for cardiovascular disease. Until now, the mainstay of dyslipidemia treatment was the use of widely available statins. These drugs, despite significantly lowering cholesterol and bringing its concentration to desired values were associated with a number of side effects. In addition, the need for daily use of statins is inconvenient for patients and leads to their irregular use and, consequently, failure to achieve the desired effect. The new drug, inclisiran, which is a PCSK9 inhibitor, represents the future in the treatment of lipid disorders. Studies conducted to date have explored the drug's mechanism of action, frequency of administration to achieve the desired effect, and side effects. The results of these studies have confirmed the significant efficacy of inclisiran,which may become a major form of treatment for dyslipidemia in the future. Purpose of the work: This article reviews the state of knowledge based on available studies on inclisiran. The aim of the review is to present the most important information about this drug related to the mechanism of action, effects on the body or assessment of efficacy. Materials and methods: The authors, based on databases such as PubMed, Scopus and Google Scholar, created a paper summarizing a review of currently available publications, concerning a new drug in the treatment of dyslipidemia- inclisiran. The authors searched for available information , using terms under the heading "key words" contained in other scientific papers. Summary Inclisiran is a novel drug that represents the future in the treatment of dyslipidemia. Due to the lack of systemic effect, it has insignificant side effects, and the need for such rare administration will allow to obtain the desired lipid concentrations even in patients who do not cooperate.

The primary purpose of this paper is to determine and prove the impact of loads with different intensities on the treadmill on the heart frequency, as well as to prove the relationship and impact of some anthropometric and motor parameters on the physiological one in the manifest space. In harmony with the purpose of the research, three basic hypotheses have been presented that cover the anthropological research fields. In this paper, 19-year-old students of the Faculty of Sports Sciences are included. To achieve the purpose of the paper, a sample of 80 students who were regular students during the year 2022/2023 was included. Four anthropometric variables, three motor tests (running tests) and four physiological tests (pulse at rest and during loads) are included in this paper. For the three groups of the system of variables, the basic statistical and distribution parameters for each variable, as well as the measures of asymmetry and normal distribution, were calculated. Then the correlations between the variables in the manifest space, as well as the correlations between the system of variables. In order to determine the relationship between predictor variables (anthropometric and motor characteristics) and criterion variables (results of functional skills), regression analysis was applied in the manifest space. The processing of the results shows that the obtained values do not deviate from the normal distribution, which completes their metric characteristics. The impact of morphological and motor factors on heart rate results has not been proven.

Introduction. The article examines the issue of the digital transformation of Ukrainian businesses. Despite the existing developed sector of information technology, domestic companies have a low level of digitalization of their activity. The methodological basis of the study were general and special research methods, including methods of theoretical generalization, analysis, synthesis, comparison and others. The information base of the study was the data of the State Statistics Service of Ukraine, National Bank of Ukraine, research of international organizations, scientific papers and other open sources. Purpose. The purpose of the article is the identification of trends in the digitalization of financial and economic activities of companies in Ukraine and the development of recommendations for improving the implementation of information technology. Results. The problem of poor access of domestic enterprises to the Internet has been identified. The largest share of companies that have websites was in the field of information technology (57,1% of all companies in the industry in 2021). The volume of sold products (goods, services) received from e-commerce in Ukraine is projected to increase to UAH 736,97 billion in 2023. The tendency to increase the share of enterprises that use cloud computing services (like using software for accounting and finance, file storage, database hosting) has been determined. Conclusions. The paper develops the main ways to improve the digital transformation of Ukrainian business: 1) creation of business site (very critical for industries with a high value of having a website); 2) providing all employees with access to the Internet; 3) improving the functionality of the website (following market trends); 4) assessment of the feasibility of purchasing a cloud computing service depends on business's specific; 5) providing the opportunity for payments by smartphones and other NFC devices when making contactless payments; 6) transition to sending invoices in electronic form purchased for automated processing (depending on the customer base).

Background: C-reactive protein (CRP) is a commonly determined biomarker of inflammation and may reflect the progression of a vascular disease. CRP values within 12 to 24 hours of stroke symptom onset are an independent predictor of adverse functional outcome in terms of the level of motor recovery in the first year of follow-up. Objective: This study aims to provide a complementary analysis of the scientific literature and critically review studies on the use of CRP as a potential biomarker associated with stroke and affecting the achievement of neurorehabilitation progress in post-stroke patients. Methods: This critical review of the literature was prepared based on the following inclusion criteria: (1) original research, (2) studies indexed in PubMed, Scopus and PEDro databases, (3) full-text articles in English, (4) papers published in 2012 – 2022, and (5) papers addressing the use of PCR assay as a biomarker of rehabilitation effectiveness. Results: Based on a review of PubMed, Scopus and PEDro databases, 47, 56 and 9 papers, respectively, were selected based on precisely selected keywords and included in full for further full text review. In this review, the most important scientific rationale was included in response to the aim of this paper. Summary: Recognition of the role of inflammatory and immunological factors in the development of atherosclerosis and the occurrence of ischaemic stroke provides scope for the search for new methods of stroke risk assessment and the development of new methods to prevent stroke. Further empirical validation and unequivocal demonstration of the levels of CRP as a potential marker that affects the health status of a post-stroke patient are needed to ensure the greatest possible level of motor recovery and ability to function independently in terms of all activities of daily living.

INTRODUCTION: Retinoids are a broad group of natural and synthetic compounds derived from vitamin A. Many studies have shown strong anti-aging effects, and they have also been shown to have therapeutic effects on acne vulgaris or psoriasis. Vitamin A and its derivatives make the skin more elastic and smooth, cause a decrease in fine wrinkles and cause an increase in fibroblast activity and collagen fiber production. Retinoid compounds regulate biological processes of the skin such as immune processes, angiogenesis, proliferation and differentiation. THE AIM OF STUDY: The purpose of this paper is to discuss the effects of retinoids and the use of the substances in skin diseases. MATERIALS AND METHOD: Literature review of PubMed, Google Scholar and Science Direct and evaluation of available randomized controlled trials using retinoids in terms of treatment effectiveness in terms of skin quality, anti-aging benefits use in dermatology. CONCLUSIONS: Vitamin A and its derivatives plays an important role in anty-aging prevention and treatment of skin diseases, such as acne vulgaris, psoriasis and photo-aging. There are still many ongoing studies and not known opportunities of its use to treat other skin diseases that we should be aware of and keep track of new papers that indicate such.

Introduction and purpose: The aim of artificial sweeteners is to replace the sweetness of sugar without contributing to the higher energy consumption or unfavorable metabolic effects conventional sugar causes. Synthetic sweeteners - one of the most popular groups - are labeled as safe for use in foods and represented by acesulfame K, aspartame, neotame, saccharin, sucralose, cyclamate and advantame. Although they underwent safety procedures, their possible unbeneficial effects are still being evaluated. In this paper we focus on their impact on the gut microbiome. Brief description of the state of knowledge: For now, the advantage of search conducted on animals is observed. Those papers show the possibility of a relationship between artificial sweeteners and composition of the gut microbiota. Changes that were observed affected the gut microbiota in a negative way as they may be responsible for causing disbalance in the conglomerate of microorganisms. Studies on humans are limited. Long term consumption of acesulfame K and sucralose is linked with modulation of the composition of the microbiota. It has also been shown that synthetic sweeteners are able to increase the ability of bacteria to form a biofilm. Conclusions: Heretofore published paperworks about the impact of synthetic sweeteners on the gut microbiota are not sufficient to conduct valuable and unambiguous conclusions. Evidence collected until now is leading to a deduction that gut microbiota can be affected by the consumption of the sugar surrogates although more data is needed to clearly determine their possible role.

This paper presents the value and role of empathy in the contemporary world. Sensitivity and empathy take crucial places in the pastoral activity of the Holy Catholic Church. Tenderness and compassion are important issues in Pope Francis’ teaching. In papal understanding, Christian dialog involves sensitivity and empathy, which let one fulfill Christ’s command to love one’s neighbor. This article explores the idea of a Christian view on empathy and brotherhood referring to official papal documents. This topic is currently crucial due to increasing splits, aggression and individualism. The paper looks for an answer how empathetic should the Church approach to the world be and according to the Pope’s teaching, how should the Church dialog profitably with people.