1. S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study
- Author
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R.J. Heine, Ronald M.A. Henry, Pieter J. Kostense, Annemarie Becker, J.M. Dekker, Tom Teerlink, Coen D.A. Stehouwer, Lex M. Bouter, Yvo M. Smulders, Giel Nijpels, A.M.W. Spijkerman, C.A.J.M. Jakobs, Internal medicine, Epidemiology and Data Science, Division 6, Pulmonary medicine, AII - Cancer immunology, CCA - Cancer biology and immunology, CCA - Cancer Treatment and quality of life, Laboratory Medicine, Dermatology, General practice, APH - Health Behaviors & Chronic Diseases, Sociology and Social Gerontology, EMGO+ - Lifestyle, Overweight and Diabetes, Interne Geneeskunde, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, and RS: CARIM School for Cardiovascular Diseases
- Subjects
Male ,medicine.medical_specialty ,S-Adenosylmethionine ,Homocysteine ,Endothelium ,Brachial Artery ,Vasodilator Agents ,Population ,Vasodilation ,chemistry.chemical_compound ,Nitroglycerin ,Folic Acid ,SDG 3 - Good Health and Well-being ,Risk Factors ,medicine.artery ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Vitamin B12 ,Brachial artery ,education ,Tetrahydrofolates ,Aged ,Ultrasonography ,education.field_of_study ,Vascular disease ,business.industry ,Middle Aged ,medicine.disease ,Vitamin B 6 ,Vitamin B 12 ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Diabetes Mellitus, Type 2 ,Cardiovascular Diseases ,Regional Blood Flow ,Female ,Endothelium, Vascular ,Cardiology and Cardiovascular Medicine ,business ,Diabetic Angiopathies - Abstract
Objective— To explore to what extent homocysteine, S-adenosylmethionine (SAM), S-adenosylhomocysteine, total folate, 5-methyltetrahydrofolate (5-MTHF), vitamin B12, and vitamin B6 are associated with endothelium-dependent, flow-mediated vasodilation (FMD), and whether these associations are stronger in individuals with diabetes or other cardiovascular risk factors. Methods and Results— In this population-based study of 608 elderly people, FMD and endothelium-independent nitroglycerin-mediated dilation (NMD) were ultrasonically estimated from the brachial artery (absolute change in diameter [μm]). High SAM and low 5-MTHF were significantly associated with high and low FMD, respectively (linear regression coefficient, [95% confidence interval]): 48.57 μm (21.16; 75.98) and −32.15 μm (−59.09; −5.20), but high homocysteine was not (−15.11 μm (−42.99; 12.78). High SAM and low 5-MTHF were also significantly associated with high and low NMD, respectively. NMD explained the association of 5-MTHF with FMD but not of SAM. No interactions were observed for diabetes or cardiovascular risk factors. Conclusions— In this elderly population, both SAM and 5-MTHF are associated with endothelial and smooth muscle cell function. The effect of homocysteine on endothelial function is relatively small compared with SAM and 5-MTHF. The relative impact of SAM, 5-MTHF, and homocysteine, and the mechanisms through which these moieties may affect endothelial and smooth muscle cell function need clarification.
- Published
- 2005