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Cardiovascular risk factors prior to the development of non-insulin-dependent diabetes mellitus in persons with impaired glucose tolerance: the Hoorn Study
- Source :
- Nijpels, M G A A M, Popp-Snijders, C, Kostense, P J, Bouter, L M & Heine, R J 1997, ' Cardiovascular risk factors prior to the development of non-insulin-dependent diabetes mellitus in persons with impaired glucose tolerance: the Hoorn Study ', Journal of Clinical Epidemiology, vol. 50, pp. 1003-1009 . https://doi.org/10.1016/S0895-4356(97)00119-4, Journal of Clinical Epidemiology, 50, 1003-1009. Elsevier USA
- Publication Year :
- 1997
-
Abstract
- The aim of the study was to analyze cardiovascular risk factors as predictors for developing non- insulin-dependent diabetes mellitus (NIDDM) in people with impaired glucose tolerance. A cross-sectional sur- vey of glucose tolerance was conducted in people, aged 50-74, w h o were randomly selected from the registry of the middle-sized town Hoorn (The Netherlands). Based on the mean values of two oral glucose tolerance tests, people were classified in glucose tolerance categories according to the WHO criteria. The mean follow- LIP> time was 36 months (range 13-55 months). The cumulative incidence of NIDDM was 34% (95% CI 16.9% 45.1). In multiple logistic regression analysis, cardiovascular risk factors at baseline did not predict the conversion from impaired glucose tolerance to NIDDM, in contrast with the two-hour plasma glucose level (odds ratio 3.56, p < 0.001) and the fasting proinsulin level, as one of the determinants of beta-cell dysfunction (Odds ratio 2.1, p < 0.05). The baseline HDL- h 1 't c o eb ero 1 1 eve , one of the components of the insulin resistance syn- 1 drome, was associated with the conversion from impaired glucose tolerance to normal glucose tolerance (Odds ratio 1.58, p < 0.05). The results of our study seem to support the hypothesis that conversion from impaired glucose tolerance to normal glucose tolerance depends on insulin resistance and the development of NIDDM from impaired glucose tolerance depends on beta-cell dysfunction. J CLIN EPIDEMIOL 50;9:1003-1009, 1997. 0 1997 Elsevier Science Inc.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Epidemiology
Impaired glucose tolerance
Insulin resistance
SDG 3 - Good Health and Well-being
Predictive Value of Tests
Risk Factors
Diabetes mellitus
Internal medicine
Glucose Intolerance
medicine
Odds Ratio
Humans
Cumulative incidence
Risk factor
Proinsulin
Aged
Netherlands
business.industry
Incidence (epidemiology)
Incidence
Cholesterol, HDL
Odds ratio
Middle Aged
medicine.disease
Endocrinology
Cross-Sectional Studies
Logistic Models
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Female
Insulin Resistance
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 08954356
- Database :
- OpenAIRE
- Journal :
- Nijpels, M G A A M, Popp-Snijders, C, Kostense, P J, Bouter, L M & Heine, R J 1997, ' Cardiovascular risk factors prior to the development of non-insulin-dependent diabetes mellitus in persons with impaired glucose tolerance: the Hoorn Study ', Journal of Clinical Epidemiology, vol. 50, pp. 1003-1009 . https://doi.org/10.1016/S0895-4356(97)00119-4, Journal of Clinical Epidemiology, 50, 1003-1009. Elsevier USA
- Accession number :
- edsair.doi.dedup.....dadaa28cc3df6578d89a7f0046c5ab9e