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S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study
- Source :
- Arteriosclerosis, Thrombosis, and Vascular Biology, 25(4), 778-784. Lippincott Williams and Wilkins, Spijkerman, A M W, Smulders, Y M, Kostense, P J, Henry, R M A, Becker, A, Teerlink, T, Jakobs, C, Dekker, J M, Nijpels, G, Heine, R J, Bouter, L M & Stehouwer, C D A 2005, ' S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine : The Hoorn Study ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 4, pp. 778-784 . https://doi.org/10.1161/01.ATV.0000157981.57694.d2, Arteriosclerosis Thrombosis and Vascular Biology, 25(4), 778-784. LIPPINCOTT WILLIAMS & WILKINS, Spijkerman, A M W, Smulders, Y M, Kostense, P J, Henry, R M A, Becker-Commissaris, A, Teerlink, T, Jakobs, C A J M, Dekker, J M, Nijpels, M G A A M, Heine, R J, Bouter, L M & Stehouwer, C D A 2005, ' S-Adenosylmethionine and 5-Methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn study ', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 4, pp. 778-784 . https://doi.org/10.1161/01.ATV.0000157981.57694.d2
- Publication Year :
- 2005
-
Abstract
- Objective— To explore to what extent homocysteine, S-adenosylmethionine (SAM), S-adenosylhomocysteine, total folate, 5-methyltetrahydrofolate (5-MTHF), vitamin B12, and vitamin B6 are associated with endothelium-dependent, flow-mediated vasodilation (FMD), and whether these associations are stronger in individuals with diabetes or other cardiovascular risk factors. Methods and Results— In this population-based study of 608 elderly people, FMD and endothelium-independent nitroglycerin-mediated dilation (NMD) were ultrasonically estimated from the brachial artery (absolute change in diameter [μm]). High SAM and low 5-MTHF were significantly associated with high and low FMD, respectively (linear regression coefficient, [95% confidence interval]): 48.57 μm (21.16; 75.98) and −32.15 μm (−59.09; −5.20), but high homocysteine was not (−15.11 μm (−42.99; 12.78). High SAM and low 5-MTHF were also significantly associated with high and low NMD, respectively. NMD explained the association of 5-MTHF with FMD but not of SAM. No interactions were observed for diabetes or cardiovascular risk factors. Conclusions— In this elderly population, both SAM and 5-MTHF are associated with endothelial and smooth muscle cell function. The effect of homocysteine on endothelial function is relatively small compared with SAM and 5-MTHF. The relative impact of SAM, 5-MTHF, and homocysteine, and the mechanisms through which these moieties may affect endothelial and smooth muscle cell function need clarification.
- Subjects :
- Male
medicine.medical_specialty
S-Adenosylmethionine
Homocysteine
Endothelium
Brachial Artery
Vasodilator Agents
Population
Vasodilation
chemistry.chemical_compound
Nitroglycerin
Folic Acid
SDG 3 - Good Health and Well-being
Risk Factors
medicine.artery
Diabetes mellitus
Internal medicine
medicine
Humans
Vitamin B12
Brachial artery
education
Tetrahydrofolates
Aged
Ultrasonography
education.field_of_study
Vascular disease
business.industry
Middle Aged
medicine.disease
Vitamin B 6
Vitamin B 12
Endocrinology
medicine.anatomical_structure
chemistry
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Regional Blood Flow
Female
Endothelium, Vascular
Cardiology and Cardiovascular Medicine
business
Diabetic Angiopathies
Subjects
Details
- Language :
- English
- ISSN :
- 10795642
- Volume :
- 25
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Arteriosclerosis Thrombosis and Vascular Biology
- Accession number :
- edsair.doi.dedup.....a6dc900c5b842c1738a9ec1e031f7707