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7. Coronary computed tomography angiography-based endothelial wall shear stress in normal coronary arteries

Author

Schultz, J., Hoogen, I.J. van den, Kuneman, J.H., Graaf, M.A. de, Kamperidis, V., Broersen, A., Jukema, J.W., Sakellarios, A., Nikopoulos, S., Tsarapatsani, K., Naka, K., Michalis, L., Fotiadis, D.I., Maaniitty, T., Saraste, A., Bax, J.J., and Knuuti, J.

Subjects
Coronary computed tomography angiography, Endothelial wall shear stress, Computational fluid dynamics, Atherosclerosis, Coronary artery disease
Abstract

Endothelial wall shear stress (ESS) is a biomechanical force which plays a role in the formation and evolution of atherosclerotic lesions. The purpose of this study is to evaluate coronary computed tomography angiography (CCTA)-based ESS in coronary arteries without atherosclerosis, and to assess factors affecting ESS values. CCTA images from patients with suspected coronary artery disease were analyzed to identify coronary arteries without atherosclerosis. Minimal and maximal ESS values were calculated for 3-mm segments. Factors potentially affecting ESS values were examined, including sex, lumen diameter and distance from the ostium. Segments were categorized according to lumen diameter tertiles into small (

Published
2022

8. Association of MMP9 with adverse features of plaque progression and residual inflammatory risk in patients with chronic coronary syndrome (CCS)

Author

Caselli, C., Giorgi, N. di, Ragusa, R., Lorenzoni, V., Smit, J., Mahdiui, M. el, Buechel, R.R., Teresinska, A., Pizzi, M.N., Roque, A., Poddighe, R., Knuuti, J., Schutte, M., Parodi, O., Pelosi, G., Scholte, A., Rocchiccioli, S., Neglia, D., SMARTool Investigators, University of Zurich, and Caselli, Chiara

Subjects
Male, Pharmacology, Computed Tomography Angiography, Physiology, MMP9, 610 Medicine & health, 10181 Clinic for Nuclear Medicine, 1314 Physiology, Coronary Artery Disease, Plaque, Atherosclerotic, Residual inflammatory risk, Anti-inflammatory therapy, 3004 Pharmacology, Matrix Metalloproteinase 9, 1313 Molecular Medicine, Humans, Molecular Medicine, Calcium, Female, Coronary atherosclerosis, RNA-seq, Adverse plaque progression
Abstract

Background and aims: MMP-9 is a predictor of atherosclerotic plaque instability and adverse cardiovascular events, but longitudinal data on the association between MMP9 and coronary disease progression are lacking. This study is aimed at investigating whether MMP9 is associated with atherosclerotic plaque progression and the related molecular basis in stable patients with chronic coronary syndrome (CCS). Methods: MMP9 serum levels were measured in 157 CCS patients (58 & PLUSMN; 8 years of age; 66% male) undergoing coronary computed tomography angiography at baseline and after a follow up period of 6.5 & PLUSMN; 1.1 years to assess progression of Total, Fibrous, Fibro-fatty, Necrotic Core, and Dense Calcium plaque volumes (PV). Gene expression analysis was evaluated in whole blood using a transcriptomic approach by RNA-seq. Results: At multivariate analysis, serum MMP9 was associated with annual change of Total and Necrotic Core PV (Coefficient 3.205, SE 1.321, P = 0.017; 1.449, SE 0.690, P = 0.038, respectively), while MMP9 gene expression with Necrotic Core PV (Coefficient 70.559, SE 32.629, P = 0.034), independently from traditional cardiovascular risk factors, medications, and presence of obstructive CAD. After transcriptomic analysis, MMP9 expression was linked to expression of genes involved in the innate immunity. Conclusions: Among CCS patients, MMP9 is an independent predictive marker of progression of adverse coronary plaques, possibly reflecting the activity of inflammatory pathways conditioning adverse plaque phenotypes. Thus, blood MMP9 might be used for the identification of patients with residual risk even with optimal man-agement of classical cardiovascular risk factors who may derive the greatest benefit from targeted anti-inflammatory drugs.

Published
2022

9. Impact of COVID-19 on the imaging diagnosis of cardiac disease in Europe

Author

Williams M. C., Shaw L., Hirschfeld C. B., Maurovich-Horvat P., Norgaard B. L., Pontone G., Jimenez-Heffernan A., Sinitsyn V., Sergienko V., Ansheles A., Bax J. J., Buechel R., Milan E., Slart R. H. J. A., Nicol E., Bucciarelli-Ducci C., Pynda Y., Better N., Cerci R., Dorbala S., Raggi P., Villines T. C., Vitola J., Malkovskiy E., Goebel B., Cohen Y., Randazzo M., Pascual T. N. B., Dondi M., Paez D., Einstein A. J., Nasery M. N., Goda A., Shirka E., Benlabgaa R., Bouyoucef S., Medjahedi A., Nailli Q., Agolti M., Aguero R. N., Del Carmen Alak M., Alberguina L. G., Arronada G., Astesiano A., Norton C. B., Benteo P., Blanco J., Bonelli J. M., Bustos J. J., Cabrejas R., Cachero J., Campisi R., Canderoli A., Carames S., Carrascosa P., Castro R., Cendoya O., Cognigni L. M., Collaud C., Cortes C., Courtis J., Cragnolino D., Daicz M., De La Vega A., De Maria S. T., Del Riego H., Dettori F., Deviggiano A., Dragonetti L., Embon M., Enriquez R. E., Ensinas J., Faccio F., Facello A., Garofalo D., Geronazzo R., Gonza N., Gutierrez L., Guzzo M. A., Hasbani V., Huerin M., Jager V., Lewkowicz J. M., De Munain M. N. A. L., Lotti J. M., Marquez A., Masoli O., Masoli O. H., Mastrovito E., Mayoraz M., Melado G. E., Mele A., Merani M. F., Meretta A. H., Molteni S., Montecinos M., Noguera E., Novoa C., Sueldo C. P., Ascani S. P., Pollono P., Pujol M. P., Radzinschi A., Raimondi G., Redruello M., Rodriguez M., Romero R. L., Acuna A. R., Rovaletti F., Miguel L. S., Solari L., Strada B., Traverso S., Traverzo S. S., Del Huerto Velazquez Espeche M., Weihmuller J. S., Wolcan J., Zeffiro S., Sakanyan M., Beuzeville S., Boktor R., Butler P., Calcott J., Carr L., Chan V., Chao C., Chong W., Dobson M., Downie D., Dwivedi G., Elison B., Engela J., Francis R., Gaikwad A., Basavaraj A. G., Goodwin B., Greenough R., Hamilton-Craig C., Hsieh V., Joshi S., Lederer K., Lee K., Lee J., Magnussen J., Mai N., Mander G., Murton F., Nandurkar D., Neill J., O'Rourke E., O'Sullivan P., Pandos G., Pathmaraj K., Pitman A., Poulter R., Premaratne M., Prior D., Ridley L., Rutherford N., Salehi H., Saunders C., Scarlett L., Seneviratne S., Shetty D., Shrestha G., Shulman J., Solanki V., Stanton T., Stuart M., Stubbs M., Swainson I., Taubman K., Taylor A., Thomas P., Unger S., Upton A., Vamadevan S., Van Gaal W., Verjans J., Voutnis D., Wayne V., Wilson P., Wong D., Wong K., Younger J., Feuchtner G., Mirzaei S., Weiss K., Maroz-Vadalazhskaya N., Gheysens O., Homans F., Moreno-Reyes R., Pasquet A., Roelants V., Van De Heyning C. M., Rios R. A., Soldat-Stankovic V., Stankovic S., Siqueira M. H. A., Almeida A., Togni P. H. A., Andrade J. H., Andrade L., Anselmi C., Araujo R., Azevedo G., Bezerra S., Biancardi R., Grossman G. B., Brandao S., Pianta D. B., Carreira L., Castro B., Chang T., Cunali F., Cury R., Dantas R., De Amorim Fernandes F., De Lorenzo A., De MacEdo Filho R., Erthal F., Fernandes F., Fernandes J., De Souza T. F., Alves W. F., Ghini B., Goncalves L., Gottlieb I., Hadlich M., Kameoka V., Lima R., Lima A., Lopes R. W., E Silva R. M., Magalhaes T., Silva F. M., Mastrocola L. E., Medeiros F., Meneghetti J. C., Naue V., Naves D., Nolasco R., Nomura C., Oliveira J. B., Paixao E., De Carvalho F. P., Pinto I., Possetti P., Quinta M., Ramos R. R. N., Rocha R., Rodrigues A., Rodrigues C., Romantini L., Sanches A., Santana S., Da Silva L. S., Schvartzman P., Matushita C. S., Senra T., Shiozaki A., De Siqueira M. E. M., Siqueira C., Smanio P., Soares C. E., Soares J., Bittencourt M. S., Spiro B., Mesquita C. T., Torreao J., Torres R., Uellendahl M., Monte G. U., Verissimo O., Cabeda E. V., Pedras F. V., Waltrick R., Zapparoli M., Naseer H., Garcheva-Tsacheva M., Kostadinova I., Theng Y., Abikhzer G., Barette R., Chow B., Dabreo D., Friedrich M., Garg R., Hafez M. N., Johnson C., Kiess M., Leipsic J., Leung E., Miller R., Oikonomou A., Probst S., Roifman I., Small G., Tandon V., Trivedi A., White J., Zukotynski K., Canessa J., Munoz G. C., Concha C., Hidalgo P., Lovera C., Massardo T., Vargas L. S., Abad P., Arturo H., Ayala S., Benitez L., Cadena A., Caicedo C., Moncayo A. C., Gomez S., Villamil C. T. G., Jaimes C., Londono J., Blair J. L. L., Pabon L., Pineda M., Rojas J. C., Ruiz D., Escobar M. V., Vasquez A., Vergel D., Zuluaga A., Gamboa I. B., Castro G., Gonzalez U., Baric A., Batinic T., Franceschi M., Hrabak M., Jukic M., Medakovic P., Persic V., Prpic M., Punda A., Batista J. F., Lauchy J. M. G., Gutierrez Y. M., Menendez R., Peix A., Rochela L., Panagidis C., Petrou I., Engelmann V., Kaminek M., Kincl V., Lang O., Simanek M., Abdulla J., Bottcher M., Christensen M., Gormsen L. C., Hasbak P., Hess S., Holdgaard P., Johansen A., Kyhl K., Ovrehus K. A., Sand N. P. R., Steffensen R., Thomassen A., Zerahn B., Perez A., Velez G. A. E., Velez M. S., Aziz I. S. A., Abougabal M., Ahmed T., Allam A., Asfour A., Hassan M., Hassan A., Ibrahim A., Kaffas S., Kandeel A., Ali M. M., Mansy A., Maurice H., Nabil S., Shaaban M., Flores A. C., Poksi A., Knuuti J., Kokkonen V., Larikka M., Uusitalo V., Bailly M., Burg S., Deux J. -F., Habouzit V., Hyafil F., Lairez O., Proffit F., Regaieg H., Sarda-Mantel L., Tacher V., Schneider R. P., Ayetey H., Angelidis G., Archontaki A., Chatziioannou S., Datseris I., Fragkaki C., Georgoulias P., Koukouraki S., Koutelou M., Kyrozi E., Repasos E., Stavrou P., Valsamaki P., Gonzalez C., Gutierrez G., Maldonado A., Buga K., Garai I., Schmidt E., Szilveszter B., Varady E., Banthia N., Bhagat J. K., Bhargava R., Bhat V., Bhatia M., Choudhury P., Chowdekar V. S., Irodi A., Jain S., Joseph E., Kumar S., Mahapatra G., Mitra D., Mittal B. R., Ozair A., Patel C., Patel T., Patel R., Patel S., Saxena S., Sengupta S., Singh S., Singh B., Sood A., Verma A., Affandi E., Alam P. S., Edison E., Gunawan G., Hapkido H., Hidayat B., Huda A., Mukti A. P., Prawiro D., Soeriadi E. A., Syawaluddin H., Albadr A., Assadi M., Emami F., Houshmand G., Maleki M., Rostami M. T., Zakavi S. R., Zaid E. A., Agranovich S., Arnson Y., Bar-Shalom R., Frenkel A., Knafo G., Lugassi R., Moalem I. S. M., Mor M., Muskal N., Ranser S., Shalev A., Albano D., Alongi P., Arnone G., Bagatin E., Baldari S., Bauckneht M., Bertelli P., Bianco F., Bonfiglioli R., Boni R., Bruno A., Bruno I., Busnardo E., Califaretti E., Camoni L., Carnevale A., Casoni R., Cavallo A. U., Cavenaghi G., Chierichetti F., Chiocchi M., Cittanti C., Colletta M., Conti U., Cossu A., Cuocolo A., Cuzzocrea M., De Rimini M. L., De Vincentis G., Del Giudice E., Del Torto A., Della Tommasina V., Durmo R., Erba P. A., Evangelista L., Faletti R., Faragasso E., Farsad M., Ferro P., Florimonte L., Frantellizzi V., Fringuelli F. M., Gatti M., Gaudiano A., Gimelli A., Giubbini R., Giuffrida F., Ialuna S., Laudicella R., Leccisotti L., Leva L., Liga R., Liguori C., Longo G., Maffione M., Mancini M. E., Marcassa C., Nardi B., Pacella S., Pepe G., Pulizzi S., Quartuccio N., Rampin L., Ricci F., Rossini P., Rubini G., Russo V., Sacchetti G. M., Sambuceti G., Scarano M., Sciagra R., Sperandio M., Stefanelli A., Ventroni G., Zoboli S., Baugh D., Chambers D., Madu E., Nunura F., Asano H., Chimura C. M., Fujimoto S., Fujisue K., Fukunaga T., Fukushima Y., Fukuyama K., Hashimoto J., Ichikawa Y., Iguchi N., Imai M., Inaki A., Ishimura H., Isobe S., Kadokami T., Kato T., Kudo T., Kumita S., Maruno H., Mataki H., Miyagawa M., Morimoto R., Moroi M., Nagamachi S., Nakajima K., Nakata T., Nakazato R., Nanasato M., Naya M., Norikane T., Ohta Y., Okayama S., Okizaki A., Otomi Y., Otsuka H., Saito M., Sakata S. Y., Sarai M., Sato D., Shiraishi S., Suwa Y., Takanami K., Takehana K., Taki J., Tamaki N., Taniguchi Y., Teragawa H., Tomizawa N., Tsujita K., Umeji K., Wakabayashi Y., Yamada S., Yamazaki S., Yoneyama T., Rawashdeh M., Batyrkhanov D., Dautov T., Makhdomi K., Ombati K., Alkandari F., Garashi M., Coie T. L., Rajvong S., Kalinin A., Kalnina M., Haidar M., Komiagiene R., Kviecinskiene G., Mataciunas M., Vajauskas D., Picard C., Karim N. K. A., Reichmuth L., Samuel A., Allarakha M. A., Naojee A. S., Alexanderson-Rosas E., Barragan E., Becerril A., Gonzalez-Montecinos, Cabada M., Rodriguez D. C., Carvajal-Juarez I., Cortes V., Cortes F., De La Pena E., Gama-Moreno M., Gonzalez L., Ramirez N. G., Jimenez-Santos M., Matos L., Monroy E., Morelos M., Ornelas M., Ramirez J. A. O., Preciado-Anaya A., Preciado-Gutierrez O. U., Barragan A. P., Uvera S. G. R., Sandoval S., Tomas M. S., Sierra-Galan L. M., Siu S., Vallejo E., Valles M., Faraggi M., Sereegotov E., Ilic S., Ben-Rais N., Alaoui N. I., Taleb S., Myo K. P. P., Thu P. S., Ghimire R. K., Rajbanshi B., Barneveld P., Glaudemans A., Habets J., Koopmans K. P., Manders J., Pool S., Scholte A., Scholtens A., Slart R., Thimister P., Van Asperen E. -J., Veltman N., Verschure D., Wagenaar N., Edmond J., Ellis C., Johnson K., Keenan R., Kueh S. H., Occleshaw C., Sasse A., To A., Van Pelt N., Young C., Cuadra T., Vanegas H. B. R., Soli I. A., Issoufou D. M., Ayodele T., Madu C., Onimode Y., Efros-Monsen E., Forsdahl S. H., Dimmen J. -M. H., Jorgensen A., Krohn I., Lovhaugen P., Braten A. T., Al Dhuhli H., Al Kindi F., Al-Bulushi N., Jawa Z., Tag N., Afzal M. S., Fatima S., Younis M. N., Riaz M., Saadullah M., Herrera Y., Lenturut-Katal D., Vazquez M. C., Ortellado J., Akhter A., Cao D., Cheung S., Dai X., Gong L., Han D., Hou Y., Li C., Li T., Li D., Li S., Liu J., Liu H., Lu B., Ng M. Y., Sun K., Tang G., Wang J., Wang X., Wang Z. -Q., Wang Y., Wu J., Wu Z., Xia L., Xiao J., Xu L., Yang Y., Yin W., Yu J., Yuan L., Zhang T., Zhang L., Zhang Y. -G., Zhang X., Zhu L., Alfaro A., Abrihan P., Barroso A., Cruz E., Gomez M. R., Magboo V. P., Medina J. M., Obaldo J., Pastrana D., Pawhay C. M., Quinon A., Tang J. M., Tecson B., Uson K. J., Uy M., Kostkiewicz M., Kunikowska J., Bettencourt N., Cantinho G., Ferreira A., Syed G., Arnous S., Atyani S., Byrne A., Gleeson T., Kerins D., Meehan C., Murphy D., Murphy M., Murray J., O'Brien J., Bang J. -I., Bom H., Cho S. -G., Hong C. M., Jang S. J., Jeong Y. H., Kang W. J., Kim J. -Y., Namgung C. K., So Y., Won K. S., Majstorov V., Vavlukis M., Salobir B. G., Stalc M., Benedek T., Benedek I., Mititelu R., Stan C. A., Dariy O., Drozdova O., Gagarina N., Gulyaev V. M., Itskovich I., Karalkin A., Kokov A., Migunova E., Pospelov V., Ryzhkova D., Saifullina G., Sazonova S., Shurupova I., Trifonova T., Ussov W. Y., Vakhromeeva M., Valiullina N., Zavadovsky K., Zhuravlev K., Alasnag M., Okarvi S., Saranovic D. S., Keng F., See J. H. J., Sekar R., Yew M. S., Vondrak A., Bejai S., Bennie G., Bester R., Engelbrecht G., Evbuomwan O., Gongxeka H., Vuuren M. J., Kaplan M., Khushica P., Lakhi H., Louw L., Malan N., Milos K., Modiselle M., More S., Naidoo M., Scholtz L., Vangu M., Aguade-Bruix S., Blanco I., Cabrera A., Camarero A., Casans-Tormo I., Cuellar-Calabria H., Flotats A., Canamero M. E. F., Garcia M. E., Leta R., Diaz J. L., Lumbreras L., Marquez-Cabeza J. J., Martin F., De Alegria A. M., Medina F., Canal M. P., Peiro V., Pubul-Nunez V., Madrid J. I. R., Rey C. R., Perez R. R., Ruiz J., Hernandez G. S., Sevilla A., Zeidan N., Nanayakkara D., Udugama C., Simonsson M., Alkadhi H., Buechel R. R., Burger P., Ceriani L., De Boeck B., Grani C., De Saint Lager Lucas A. J., Kamani C. H., Kawel-Boehm N., Manka R., Prior J. O., Rominger A., Vallee J. -P., Khiewvan B., Premprabha T., Thientunyakit T., Sellem A., Kir K. M., Sayman H., Sebikali M. J., Muyinda Z., Kmetyuk Y., Korol P., Mykhalchenko O., Pliatsek V., Satyr M., Albalooshi B., Hassan M. I. A., Anderson J., Bedi P., Biggans T., Bularga A., Bull R., Burgul R., Carpenter J. -P., Coles D., Cusack D., Deshpande A., Dougan J., Fairbairn T., Farrugia A., Gopalan D., Gummow A., Ramkumar P. G., Hamilton M., Harbinson M., Hartley T., Hudson B., Joshi N., Kay M., Kelion A., Khokhar A., Kitt J., Low C., Mak S. M., Marousa N., Martin J., McAlindon E., Menezes L., Morgan-Hughes G., Moss A., Murray A., Patel D., Peebles C., Pugliese F., Rodrigues J. C. L., Rofe C., Sabharwal N., Schofield R., Semple T., Sharma N., Strouhal P., Subedi D., Topping W., Tweed K., Weir-Mccall J., Abbara S., Abbasi T., Abbott B., Abohashem S., Abramson S., Al-Abboud T., Al-Mallah M., Almousalli O., Ananthasubramaniam K., Kumar M. A., Askew J., Attanasio L., Balmer-Swain M., Bayer R. R., Bernheim A., Bhatti S., Bieging E., Blankstein R., Bloom S., Blue S., Bluemke D., Borges A., Branch K., Bravo P., Brothers J., Budoff M., Bullock-Palmer R., Burandt A., Burke F. W., Bush K., Candela C., Capasso E., Cavalcante J., Chang D., Chatterjee S., Chatzizisis Y., Cheezum M., Chen T., Chen J., Chen M., Choi A., Clarcq J., Cordero A., Crim M., Danciu S., Decter B., Dhruva N., Doherty N., Doukky R., Dunbar A., Duvall W., Edwards R., Esquitin K., Farah H., Fentanes E., Ferencik M., Fisher D., Fitzpatrick D., Foster C., Fuisz T., Gannon M., Gastner L., Gerson M., Ghoshhajra B., Goldberg A., Goldner B., Gonzalez J., Gore R., Gracia-Lopez S., Hage F., Haider A., Haider S., Hamirani Y., Hassen K., Hatfield M., Hawkins C., Hawthorne K., Heath N., Hendel R., Hernandez P., Hill G., Horgan S., Huffman J., Hurwitz L., Iskandrian A., Janardhanan R., Jellis C., Jerome S., Kalra D., Kaviratne S., Kay F., Kelly F., Khalique O., Kinkhabwala M., Iii G. K., Kircher J., Kirkbride R., Kontos M., Kottam A., Krepp J., Layer J., Lee S. H., Leppo J., Lesser J., Leung S., Lewin H., Litmanovich D., Liu Y., Lopez-Mattei J., Magurany K., Markowitz J., Marn A., Matis S. E., McKenna M., McRae T., Mendoza F., Merhige M., Min D., Moffitt C., Moncher K., Moore W., Morayati S., Morris M., Mossa-Basha M., Mrsic Z., Murthy V., Nagpal P., Napier K., Narula J., Nelson K., Nijjar P., Osman M., Parwani P., Passen E., Patel A., Patil P., Paul R., Phillips L., Polsani V., Poludasu R., Pomerantz B., Porter T., Prentice R., Pursnani A., Rabbat M., Ramamurti S., Rich F., Luna H. R., Robinson A., Robles K., Rodriguez C., Rorie M., Rumberger J., Russell R., Sabra P., Sadler D., Schemmer M., Schoepf U. J., Shah S., Shah N., Shanbhag S., Sharma G., Shayani S., Shirani J., Shivaram P., Sigman S., Simon M., Slim A., Smith D., Smith A., Soman P., Srichai-Parsia M. B., Streeter J., Albert T., Tawakol A., Thomas D., Thompson R., Torbet T., Trinidad D., Ullery S., Unzek S., Uretsky S., Vallurupalli S., Verma V., Waller A., Wang E., Ward P., Weissman G., Wesbey G., White K., Winchester D., Wolinsky D., Yost S., Zgaljardic M., Alonso O., Beretta M., Ferrando R., Kapitan M., Mut F., Djuraev O., Rozikhodjaeva G., Ngoc H. L., Mai S. H., Nguyen X. C., Williams, M, Shaw, L, Hirschfeld, C, Maurovich-Horvat, P, Norgaard, B, Pontone, G, Jimenez-Heffernan, A, Sinitsyn, V, Sergienko, V, Ansheles, A, Bax, J, Buechel, R, Milan, E, Slart, R, Nicol, E, Bucciarelli-Ducci, C, Pynda, Y, Better, N, Cerci, R, Dorbala, S, Raggi, P, Villines, T, Vitola, J, Malkovskiy, E, Goebel, B, Cohen, Y, Randazzo, M, Pascual, T, Dondi, M, Paez, D, Einstein, A, Nasery, M, Goda, A, Shirka, E, Benlabgaa, R, Bouyoucef, S, Medjahedi, A, Nailli, Q, Agolti, M, Aguero, R, Del Carmen Alak, M, Alberguina, L, Arronada, G, Astesiano, A, Norton, C, Benteo, P, Blanco, J, Bonelli, J, Bustos, J, Cabrejas, R, Cachero, J, Campisi, R, Canderoli, A, Carames, S, Carrascosa, P, Castro, R, Cendoya, O, Cognigni, L, Collaud, C, Cortes, C, Courtis, J, Cragnolino, D, Daicz, M, De La Vega, A, De Maria, S, Del Riego, H, Dettori, F, Deviggiano, A, Dragonetti, L, Embon, M, Enriquez, R, Ensinas, J, Faccio, F, Facello, A, Garofalo, D, Geronazzo, R, Gonza, N, Gutierrez, L, Guzzo, M, Hasbani, V, Huerin, M, Jager, V, Lewkowicz, J, De Munain, M, Lotti, J, Marquez, A, Masoli, O, Mastrovito, E, Mayoraz, M, Melado, G, Mele, A, Merani, M, Meretta, A, Molteni, S, Montecinos, M, Noguera, E, Novoa, C, Sueldo, C, Ascani, S, Pollono, P, Pujol, M, Radzinschi, A, Raimondi, G, Redruello, M, Rodriguez, M, Romero, R, Acuna, A, Rovaletti, F, Miguel, L, Solari, L, Strada, B, Traverso, S, Traverzo, S, Del Huerto Velazquez Espeche, M, Weihmuller, J, Wolcan, J, Zeffiro, S, Sakanyan, M, Beuzeville, S, Boktor, R, Butler, P, Calcott, J, Carr, L, Chan, V, Chao, C, Chong, W, Dobson, M, Downie, D, Dwivedi, G, Elison, B, Engela, J, Francis, R, Gaikwad, A, Basavaraj, A, Goodwin, B, Greenough, R, Hamilton-Craig, C, Hsieh, V, Joshi, S, Lederer, K, Lee, K, Lee, J, Magnussen, J, Mai, N, Mander, G, Murton, F, Nandurkar, D, Neill, J, O'Rourke, E, O'Sullivan, P, Pandos, G, Pathmaraj, K, Pitman, A, Poulter, R, Premaratne, M, Prior, D, Ridley, L, Rutherford, N, Salehi, H, Saunders, C, Scarlett, L, Seneviratne, S, Shetty, D, Shrestha, G, Shulman, J, Solanki, V, Stanton, T, Stuart, M, Stubbs, M, Swainson, I, Taubman, K, Taylor, A, Thomas, P, Unger, S, Upton, A, Vamadevan, S, Van Gaal, W, Verjans, J, Voutnis, D, Wayne, V, Wilson, P, Wong, D, Wong, K, Younger, J, Feuchtner, G, Mirzaei, S, Weiss, K, Maroz-Vadalazhskaya, N, Gheysens, O, Homans, F, Moreno-Reyes, R, Pasquet, A, Roelants, V, Van De Heyning, C, Rios, R, Soldat-Stankovic, V, Stankovic, S, Siqueira, M, Almeida, A, Togni, P, Andrade, J, Andrade, L, Anselmi, C, Araujo, R, Azevedo, G, Bezerra, S, Biancardi, R, Grossman, G, Brandao, S, Pianta, D, Carreira, L, Castro, B, Chang, T, Cunali, F, Cury, R, Dantas, R, De Amorim Fernandes, F, De Lorenzo, A, De MacEdo Filho, R, Erthal, F, Fernandes, F, Fernandes, J, De Souza, T, Alves, W, Ghini, B, Goncalves, L, Gottlieb, I, Hadlich, M, Kameoka, V, Lima, R, Lima, A, Lopes, R, E Silva, R, Magalhaes, T, Silva, F, Mastrocola, L, Medeiros, F, Meneghetti, J, Naue, V, Naves, D, Nolasco, R, Nomura, C, Oliveira, J, Paixao, E, De Carvalho, F, Pinto, I, Possetti, P, Quinta, M, Ramos, R, Rocha, R, Rodrigues, A, Rodrigues, C, Romantini, L, Sanches, A, Santana, S, Da Silva, L, Schvartzman, P, Matushita, C, Senra, T, Shiozaki, A, De Siqueira, M, Siqueira, C, Smanio, P, Soares, C, Soares, J, Bittencourt, M, Spiro, B, Mesquita, C, Torreao, J, Torres, R, Uellendahl, M, Monte, G, Verissimo, O, Cabeda, E, Pedras, F, Waltrick, R, Zapparoli, M, Naseer, H, Garcheva-Tsacheva, M, Kostadinova, I, Theng, Y, Abikhzer, G, Barette, R, Chow, B, Dabreo, D, Friedrich, M, Garg, R, Hafez, M, Johnson, C, Kiess, M, Leipsic, J, Leung, E, Miller, R, Oikonomou, A, Probst, S, Roifman, I, Small, G, Tandon, V, Trivedi, A, White, J, Zukotynski, K, Canessa, J, Munoz, G, Concha, C, Hidalgo, P, Lovera, C, Massardo, T, Vargas, L, Abad, P, Arturo, H, Ayala, S, Benitez, L, Cadena, A, Caicedo, C, Moncayo, A, Gomez, S, Villamil, C, Jaimes, C, Londono, J, Blair, J, Pabon, L, Pineda, M, Rojas, J, Ruiz, D, Escobar, M, Vasquez, A, Vergel, D, Zuluaga, A, Gamboa, I, Castro, G, Gonzalez, U, Baric, A, Batinic, T, Franceschi, M, Hrabak, M, Jukic, M, Medakovic, P, Persic, V, Prpic, M, Punda, A, Batista, J, Lauchy, J, Gutierrez, Y, Menendez, R, Peix, A, Rochela, L, Panagidis, C, Petrou, I, Engelmann, V, Kaminek, M, Kincl, V, Lang, O, Simanek, M, Abdulla, J, Bottcher, M, Christensen, M, Gormsen, L, Hasbak, P, Hess, S, Holdgaard, P, Johansen, A, Kyhl, K, Ovrehus, K, Sand, N, Steffensen, R, Thomassen, A, Zerahn, B, Perez, A, Velez, G, Velez, M, Aziz, I, Abougabal, M, Ahmed, T, Allam, A, Asfour, A, Hassan, M, Hassan, A, Ibrahim, A, Kaffas, S, Kandeel, A, Ali, M, Mansy, A, Maurice, H, Nabil, S, Shaaban, M, Flores, A, Poksi, A, Knuuti, J, Kokkonen, V, Larikka, M, Uusitalo, V, Bailly, M, Burg, S, Deux, J, Habouzit, V, Hyafil, F, Lairez, O, Proffit, F, Regaieg, H, Sarda-Mantel, L, Tacher, V, Schneider, R, Ayetey, H, Angelidis, G, Archontaki, A, Chatziioannou, S, Datseris, I, Fragkaki, C, Georgoulias, P, Koukouraki, S, Koutelou, M, Kyrozi, E, Repasos, E, Stavrou, P, Valsamaki, P, Gonzalez, C, Gutierrez, G, Maldonado, A, Buga, K, Garai, I, Schmidt, E, Szilveszter, B, Varady, E, Banthia, N, Bhagat, J, Bhargava, R, Bhat, V, Bhatia, M, Choudhury, P, Chowdekar, V, Irodi, A, Jain, S, Joseph, E, Kumar, S, Mahapatra, G, Mitra, D, Mittal, B, Ozair, A, Patel, C, Patel, T, Patel, R, Patel, S, Saxena, S, Sengupta, S, Singh, S, Singh, B, Sood, A, Verma, A, Affandi, E, Alam, P, Edison, E, Gunawan, G, Hapkido, H, Hidayat, B, Huda, A, Mukti, A, Prawiro, D, Soeriadi, E, Syawaluddin, H, Albadr, A, Assadi, M, Emami, F, Houshmand, G, Maleki, M, Rostami, M, Zakavi, S, Zaid, E, Agranovich, S, Arnson, Y, Bar-Shalom, R, Frenkel, A, Knafo, G, Lugassi, R, Moalem, I, Mor, M, Muskal, N, Ranser, S, Shalev, A, Albano, D, Alongi, P, Arnone, G, Bagatin, E, Baldari, S, Bauckneht, M, Bertelli, P, Bianco, F, Bonfiglioli, R, Boni, R, Bruno, A, Bruno, I, Busnardo, E, Califaretti, E, Camoni, L, Carnevale, A, Casoni, R, Cavallo, A, Cavenaghi, G, Chierichetti, F, Chiocchi, M, Cittanti, C, Colletta, M, Conti, U, Cossu, A, Cuocolo, A, Cuzzocrea, M, De Rimini, M, De Vincentis, G, Del Giudice, E, Del Torto, A, Della Tommasina, V, Durmo, R, Erba, P, Evangelista, L, Faletti, R, Faragasso, E, Farsad, M, Ferro, P, Florimonte, L, Frantellizzi, V, Fringuelli, F, Gatti, M, Gaudiano, A, Gimelli, A, Giubbini, R, Giuffrida, F, Ialuna, S, Laudicella, R, Leccisotti, L, Leva, L, Liga, R, Liguori, C, Longo, G, Maffione, M, Mancini, M, Marcassa, C, Nardi, B, Pacella, S, Pepe, G, Pulizzi, S, Quartuccio, N, Rampin, L, Ricci, F, Rossini, P, Rubini, G, Russo, V, Sacchetti, G, Sambuceti, G, Scarano, M, Sciagra, R, Sperandio, M, Stefanelli, A, Ventroni, G, Zoboli, S, Baugh, D, Chambers, D, Madu, E, Nunura, F, Asano, H, Chimura, C, Fujimoto, S, Fujisue, K, Fukunaga, T, Fukushima, Y, Fukuyama, K, Hashimoto, J, Ichikawa, Y, Iguchi, N, Imai, M, Inaki, A, Ishimura, H, Isobe, S, Kadokami, T, Kato, T, Kudo, T, Kumita, S, Maruno, H, Mataki, H, Miyagawa, M, Morimoto, R, Moroi, M, Nagamachi, S, Nakajima, K, Nakata, T, Nakazato, R, Nanasato, M, Naya, M, Norikane, T, Ohta, Y, Okayama, S, Okizaki, A, Otomi, Y, Otsuka, H, Saito, M, Sakata, S, Sarai, M, Sato, D, Shiraishi, S, Suwa, Y, Takanami, K, Takehana, K, Taki, J, Tamaki, N, Taniguchi, Y, Teragawa, H, Tomizawa, N, Tsujita, K, Umeji, K, Wakabayashi, Y, Yamada, S, Yamazaki, S, Yoneyama, T, Rawashdeh, M, Batyrkhanov, D, Dautov, T, Makhdomi, K, Ombati, K, Alkandari, F, Garashi, M, Coie, T, Rajvong, S, Kalinin, A, Kalnina, M, Haidar, M, Komiagiene, R, Kviecinskiene, G, Mataciunas, M, Vajauskas, D, Picard, C, Karim, N, Reichmuth, L, Samuel, A, Allarakha, M, Naojee, A, Alexanderson-Rosas, E, Barragan, E, Becerril, A, Gonzalez-Montecinos, Cabada, M, Rodriguez, D, Carvajal-Juarez, I, Cortes, V, Cortes, F, De La Pena, E, Gama-Moreno, M, Gonzalez, L, Ramirez, N, Jimenez-Santos, M, Matos, L, Monroy, E, Morelos, M, Ornelas, M, Ramirez, J, Preciado-Anaya, A, Preciado-Gutierrez, O, Barragan, A, Uvera, S, Sandoval, S, Tomas, M, Sierra-Galan, L, Siu, S, Vallejo, E, Valles, M, Faraggi, M, Sereegotov, E, Ilic, S, Ben-Rais, N, Alaoui, N, Taleb, S, Myo, K, Thu, P, Ghimire, R, Rajbanshi, B, Barneveld, P, Glaudemans, A, Habets, J, Koopmans, K, Manders, J, Pool, S, Scholte, A, Scholtens, A, Thimister, P, Van Asperen, E, Veltman, N, Verschure, D, Wagenaar, N, Edmond, J, Ellis, C, Johnson, K, Keenan, R, Kueh, S, Occleshaw, C, Sasse, A, To, A, Van Pelt, N, Young, C, Cuadra, T, Vanegas, H, Soli, I, Issoufou, D, Ayodele, T, Madu, C, Onimode, Y, Efros-Monsen, E, Forsdahl, S, Dimmen, J, Jorgensen, A, Krohn, I, Lovhaugen, P, Braten, A, Al Dhuhli, H, Al Kindi, F, Al-Bulushi, N, Jawa, Z, Tag, N, Afzal, M, Fatima, S, Younis, M, Riaz, M, Saadullah, M, Herrera, Y, Lenturut-Katal, D, Vazquez, M, Ortellado, J, Akhter, A, Cao, D, Cheung, S, Dai, X, Gong, L, Han, D, Hou, Y, Li, C, Li, T, Li, D, Li, S, Liu, J, Liu, H, Lu, B, Ng, M, Sun, K, Tang, G, Wang, J, Wang, X, Wang, Z, Wang, Y, Wu, J, Wu, Z, Xia, L, Xiao, J, Xu, L, Yang, Y, Yin, W, Yu, J, Yuan, L, Zhang, T, Zhang, L, Zhang, Y, Zhang, X, Zhu, L, Alfaro, A, Abrihan, P, Barroso, A, Cruz, E, Gomez, M, Magboo, V, Medina, J, Obaldo, J, Pastrana, D, Pawhay, C, Quinon, A, Tang, J, Tecson, B, Uson, K, Uy, M, Kostkiewicz, M, Kunikowska, J, Bettencourt, N, Cantinho, G, Ferreira, A, Syed, G, Arnous, S, Atyani, S, Byrne, A, Gleeson, T, Kerins, D, Meehan, C, Murphy, D, Murphy, M, Murray, J, O'Brien, J, Bang, J, Bom, H, Cho, S, Hong, C, Jang, S, Jeong, Y, Kang, W, Kim, J, Namgung, C, So, Y, Won, K, Majstorov, V, Vavlukis, M, Salobir, B, Stalc, M, Benedek, T, Benedek, I, Mititelu, R, Stan, C, Dariy, O, Drozdova, O, Gagarina, N, Gulyaev, V, Itskovich, I, Karalkin, A, Kokov, A, Migunova, E, Pospelov, V, Ryzhkova, D, Saifullina, G, Sazonova, S, Shurupova, I, Trifonova, T, Ussov, W, Vakhromeeva, M, Valiullina, N, Zavadovsky, K, Zhuravlev, K, Alasnag, M, Okarvi, S, Saranovic, D, Keng, F, See, J, Sekar, R, Yew, M, Vondrak, A, Bejai, S, Bennie, G, Bester, R, Engelbrecht, G, Evbuomwan, O, Gongxeka, H, Vuuren, M, Kaplan, M, Khushica, P, Lakhi, H, Louw, L, Malan, N, Milos, K, Modiselle, M, More, S, Naidoo, M, Scholtz, L, Vangu, M, Aguade-Bruix, S, Blanco, I, Cabrera, A, Camarero, A, Casans-Tormo, I, Cuellar-Calabria, H, Flotats, A, Canamero, M, Garcia, M, Leta, R, Diaz, J, Lumbreras, L, Marquez-Cabeza, J, Martin, F, De Alegria, A, Medina, F, Canal, M, Peiro, V, Pubul-Nunez, V, Madrid, J, Rey, C, Perez, R, Ruiz, J, Hernandez, G, Sevilla, A, Zeidan, N, Nanayakkara, D, Udugama, C, Simonsson, M, Alkadhi, H, Burger, P, Ceriani, L, De Boeck, B, Grani, C, De Saint Lager Lucas, A, Kamani, C, Kawel-Boehm, N, Manka, R, Prior, J, Rominger, A, Vallee, J, Khiewvan, B, Premprabha, T, Thientunyakit, T, Sellem, A, Kir, K, Sayman, H, Sebikali, M, Muyinda, Z, Kmetyuk, Y, Korol, P, Mykhalchenko, O, Pliatsek, V, Satyr, M, Albalooshi, B, Anderson, J, Bedi, P, Biggans, T, Bularga, A, Bull, R, Burgul, R, Carpenter, J, Coles, D, Cusack, D, Deshpande, A, Dougan, J, Fairbairn, T, Farrugia, A, Gopalan, D, Gummow, A, Ramkumar, P, Hamilton, M, Harbinson, M, Hartley, T, Hudson, B, Joshi, N, Kay, M, Kelion, A, Khokhar, A, Kitt, J, Low, C, Mak, S, Marousa, N, Martin, J, Mcalindon, E, Menezes, L, Morgan-Hughes, G, Moss, A, Murray, A, Patel, D, Peebles, C, Pugliese, F, Rodrigues, J, Rofe, C, Sabharwal, N, Schofield, R, Semple, T, Sharma, N, Strouhal, P, Subedi, D, Topping, W, Tweed, K, Weir-Mccall, J, Abbara, S, Abbasi, T, Abbott, B, Abohashem, S, Abramson, S, Al-Abboud, T, Al-Mallah, M, Almousalli, O, Ananthasubramaniam, K, Kumar, M, Askew, J, Attanasio, L, Balmer-Swain, M, Bayer, R, Bernheim, A, Bhatti, S, Bieging, E, Blankstein, R, Bloom, S, Blue, S, Bluemke, D, Borges, A, Branch, K, Bravo, P, Brothers, J, Budoff, M, Bullock-Palmer, R, Burandt, A, Burke, F, Bush, K, Candela, C, Capasso, E, Cavalcante, J, Chang, D, Chatterjee, S, Chatzizisis, Y, Cheezum, M, Chen, T, Chen, J, Chen, M, Choi, A, Clarcq, J, Cordero, A, Crim, M, Danciu, S, Decter, B, Dhruva, N, Doherty, N, Doukky, R, Dunbar, A, Duvall, W, Edwards, R, Esquitin, K, Farah, H, Fentanes, E, Ferencik, M, Fisher, D, Fitzpatrick, D, Foster, C, Fuisz, T, Gannon, M, Gastner, L, Gerson, M, Ghoshhajra, B, Goldberg, A, Goldner, B, Gonzalez, J, Gore, R, Gracia-Lopez, S, Hage, F, Haider, A, Haider, S, Hamirani, Y, Hassen, K, Hatfield, M, Hawkins, C, Hawthorne, K, Heath, N, Hendel, R, Hernandez, P, Hill, G, Horgan, S, Huffman, J, Hurwitz, L, Iskandrian, A, Janardhanan, R, Jellis, C, Jerome, S, Kalra, D, Kaviratne, S, Kay, F, Kelly, F, Khalique, O, Kinkhabwala, M, Iii, G, Kircher, J, Kirkbride, R, Kontos, M, Kottam, A, Krepp, J, Layer, J, Lee, S, Leppo, J, Lesser, J, Leung, S, Lewin, H, Litmanovich, D, Liu, Y, Lopez-Mattei, J, Magurany, K, Markowitz, J, Marn, A, Matis, S, Mckenna, M, Mcrae, T, Mendoza, F, Merhige, M, Min, D, Moffitt, C, Moncher, K, Moore, W, Morayati, S, Morris, M, Mossa-Basha, M, Mrsic, Z, Murthy, V, Nagpal, P, Napier, K, Narula, J, Nelson, K, Nijjar, P, Osman, M, Parwani, P, Passen, E, Patel, A, Patil, P, Paul, R, Phillips, L, Polsani, V, Poludasu, R, Pomerantz, B, Porter, T, Prentice, R, Pursnani, A, Rabbat, M, Ramamurti, S, Rich, F, Luna, H, Robinson, A, Robles, K, Rodriguez, C, Rorie, M, Rumberger, J, Russell, R, Sabra, P, Sadler, D, Schemmer, M, Schoepf, U, Shah, S, Shah, N, Shanbhag, S, Sharma, G, Shayani, S, Shirani, J, Shivaram, P, Sigman, S, Simon, M, Slim, A, Smith, D, Smith, A, Soman, P, Srichai-Parsia, M, Streeter, J, Albert, T, Tawakol, A, Thomas, D, Thompson, R, Torbet, T, Trinidad, D, Ullery, S, Unzek, S, Uretsky, S, Vallurupalli, S, Verma, V, Waller, A, Wang, E, Ward, P, Weissman, G, Wesbey, G, White, K, Winchester, D, Wolinsky, D, Yost, S, Zgaljardic, M, Alonso, O, Beretta, M, Ferrando, R, Kapitan, M, Mut, F, Djuraev, O, Rozikhodjaeva, G, Ngoc, H, Mai, S, Nguyen, X, ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Translational Immunology Groningen (TRIGR), and Cardiovascular Centre (CVC)

Subjects
INCAPS COVID Investigators Group, cardiac imaging techniques, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, Practice Patterns, Disease, Cardiovascular, coronary artery disease, COVID-19, Cardiac Imaging Techniques, Cardiologists, Europe, Health Care Surveys, Healthcare Disparities, Heart Diseases, Humans, Practice Patterns, Physicians', Predictive Value of Tests, Gross domestic product, Human health, cardiovascular disease, Pandemic, Medicine, cardiovascular imaging, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, cardiac imaging technique, Predictive value of tests, Cardiology and Cardiovascular Medicine, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija, cardiac disease, Coronavirus disease 2019 (COVID-19), Independent predictor, cardiac imaging, NO, Imaging diagnosis, Diseases of the circulatory (Cardiovascular) system, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, Physicians', business.industry, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology, RC666-701, HOSPITALIZATIONS, business, Health Care Delivery, Economics and Global Health Care, Demography
Abstract

ObjectivesWe aimed to explore the impact of the COVID-19 pandemic on cardiac diagnostic testing and practice and to assess its impact in different regions in Europe.MethodsThe online survey organised by the International Atomic Energy Agency Division of Human Health collected information on changes in cardiac imaging procedural volumes between March 2019 and March/April 2020. Data were collected from 909 centres in 108 countries.ResultsCentres in Northern and Southern Europe were more likely to cancel all outpatient activities compared with Western and Eastern Europe. There was a greater reduction in total procedure volumes in Europe compared with the rest of the world in March 2020 (45% vs 41%, p=0.003), with a more marked reduction in Southern Europe (58%), but by April 2020 this was similar in Europe and the rest of the world (69% vs 63%, p=0.261). Regional variations were apparent between imaging modalities, but the largest reductions were in Southern Europe for nearly all modalities. In March 2020, location in Southern Europe was the only independent predictor of the reduction in procedure volume. However, in April 2020, lower gross domestic product and higher COVID-19 deaths were the only independent predictors.ConclusionThe first wave of the COVID-19 pandemic had a significant impact on care of patients with cardiac disease, with substantial regional variations in Europe. This has potential long-term implications for patients and plans are required to enable the diagnosis of non-COVID-19 conditions during the ongoing pandemic.

Published
2021

10. Coronary Computed Tomographic Angiography for Complete Assessment of Coronary Artery Disease: JACC State-of-the-Art Review

Author

Serruys, P.W., Hara, H., Garg, S., Kawashima, H., Norgaard, B.L., Dweck, M.R., Bax, J.J., Knuuti, J., Nieman, K., Leipsic, J.A., Mushtaq, S., Andreini, D., and Onuma, Y.

Subjects
coronary physiology, cardiovascular diseases, coronary plaque, coronary computed tomography angiography
Abstract

Coronary computed tomography angiography (CTA) has shown great technological improvements over the last 2 decades. High accuracy of CTA in detecting significant coronary stenosis has promoted CTA as a substitute for conven-tional invasive coronary angiography in patients with suspected coronary artery disease. In patients with coronary stenosis, CTA-derived physiological assessment is surrogate for intracoronary pressure and velocity wires, and renders possible decision-making about revascularization solely based on computed tomography. Computed tomography coro-nary anatomy with functionality assessment could potentially become a first line in diagnosis. Noninvasive imaging assessment of plaque burden and morphology is becoming a valuable substitute for intravascular imaging. Recently, wall shear stress and perivascular inflammation have been introduced. These assessments could support risk management for both primary and secondary cardiovascular prevention. Anatomy, functionality, and plaque composition by CTA tend to replace invasive assessment. Complete CTA assessment could provide a 1-stop-shop for diagnosis, risk management, and decision-making on treatment. (J Am Coll Cardiol 2021;78:713-736) (c) 2021 by the American College of Cardiology Foundation.

Published
2021

13. Validation of [18F]fluorodeoxyglucose and positron emission tomography (PET) for the measurement of intestinal metabolism in pigs, and evidence of intestinal insulin resistance in patients with morbid obesity

Author

Honka, H., Mäkinen, J., Hannukainen, J. C., Tarkia, M., Oikonen, V., Teräs, M., Fagerholm, V., Ishizu, T., Saraste, A., Stark, C., Vähäsilta, T., Salminen, P., Kirjavainen, A., Soinio, M., Gastaldelli, A., Knuuti, J., Iozzo, P., and Nuutila, P.

Published
2013
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14. Global and segmental absolute stress myocardial blood flow in prediction of cardiac events:[¹⁵O] water positron emission tomography study

Author

Harjulahti, E. (Esa), Maaniitty, T. (Teemu), Nammas, W. (Wail), Stenström, I. (Iida), Biancari, F. (Fausto), Bax, J. J. (Jeroen J.), Knuuti, J. (Juhani), and Saraste, A. (Antti)

Subjects
Positron emission tomography, Net reclassification improvement, Chronic coronary syndromes, Myocardial blood flow
Abstract

Purpose: We evaluated the value of reduced global and segmental absolute stress myocardial blood flow (sMBF) quantified by [¹⁵O] water positron emission tomography (PET) for predicting cardiac events in patients with suspected obstructive coronary artery disease (CAD). Methods: Global and segmental sMBF during adenosine stress were retrospectively quantified in 530 symptomatic patients who underwent [¹⁵O] water PET for evaluation of coronary stenosis detected by coronary computed tomography angiography. Results: Cardiovascular death, myocardial infarction, or unstable angina occurred in 28 (5.3%) patients at a 4-year follow-up. Reduced global sMBF was associated with events (area under the receiver operating characteristic curve 0.622, 95% confidence interval (95% CI) 0.538–0.707, p = 0.006). Reduced global sMBF (

Published
2021

15. Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia: The IAEA INCAPS-COVID Study

Author

Kudo, T., Lahey, R., Hirschfeld, C.B., Williams, M.C., Lu, B., Alasnag, M., Bhatia, M., Henry Bom, H.-., Dautov, T., Fazel, R., Karthikeyan, G., Keng, F.Y.J., Rubinshtein, R., Better, N., Cerci, R.J., Dorbala, S., Raggi, P., Shaw, L.J., Villines, T.C., Vitola, J.V., Choi, A.D., Malkovskiy, E., Goebel, B., Cohen, Y.A., Randazzo, M., Pascual, T.N.B., Pynda, Y., Dondi, M., Paez, D., Einstein, A.J., Cerci, R., Hinterleitner, G., Lu, Y., Morozova, O., Xu, Z., Cohen, Y., Choi, A., Lopez-Mattei, J., Parwani, P., Nasery, M.N., Goda, A., Shirka, E., Benlabgaa, R., Bouyoucef, S., Medjahedi, A., Nailli, Q., Agolti, M., Aguero, R.N., Alak, M.D.C., Alberguina, L.G., Arronada, G., Astesiano, A., Norton, C.B., Benteo, P., Blanco, J., Bonelli, J.M., Bustos, J.J., Cabrejas, R., Cachero, J., Campisi, R., Canderoli, A., Carames, S., Carrascosa, P., Castro, R., Cendoya, O., Cognigni, L.M., Collaud, C., Cortes, C., Courtis, J., Cragnolino, D., Daicz, M., De La Vega, A., De Maria, S.T., Del Riego, H., Dettori, F., Deviggiano, A., Dragonetti, L., Embon, M., Enriquez, R.E., Ensinas, J., Faccio, F., Facello, A., Garofalo, D., Geronazzo, R., Gonza, N., Gutierrez, L., Guzzo, M.A., Hasbani, V., Huerin, M., Jager, V., Lewkowicz, J.M., Lopez De Munain, M.N.A., Lotti, J.M., Marquez, A., Masoli, O., Masoli, O.H., Mastrovito, E., Mayoraz, M., Melado, G.E., Mele, A., Merani, M.F., Meretta, A.H., Molteni, S., Montecinos, M., Noguera, E., Novoa, C., Sueldo, C.P., Ascani, S.P., Pollono, P., Pujol, M.P., Radzinschi, A., Raimondi, G., Redruello, M., Rodriguez, M., Romero, R.L., Acuna, A.R., Rovaletti, F., San Miguel, L., Solari, L., Strada, B., Traverso, S., Traverzo, S.S., Espeche, M.D.H.V., Weihmuller, J.S., Wolcan, J., Zeffiro, S., Sakanyan, M., Beuzeville, S., Boktor, R., Butler, P., Calcott, J., Carr, L., Chan, V., Chao, C., Chong, W., Dobson, M., Downie, D.A., Dwivedi, G., Elison, B., Engela, J., Francis, R., Gaikwad, A., Basavaraj, A.G., Goodwin, B., Greenough, R., Hamilton-Craig, C., Hsieh, V., Joshi, S., Lederer, K., Lee, K., Lee, J., Magnussen, J., Mai, N., Mander, G., Murton, F., Nandurkar, D., Neill, J., O'Rourke, E., O'Sullivan, P., Pandos, G., Pathmaraj, K., Pitman, A., Poulter, R., Premaratne, M., Prior, D., Ridley, L., Rutherford, N., Salehi, H., Saunders, C., Scarlett, L., Seneviratne, S., Shetty, D., Shrestha, G., Shulman, J., Solanki, V., Stanton, T., Stuart, M., Stubbs, M., Swainson, I., Taubman, K., Taylor, A., Thomas, P., Unger, S., Upton, A., Vamadevan, S., Van Gaal, W., Verjans, J., Voutnis, D., Wayne, V., Wilson, P., Wong, D., Wong, K., Younger, J., Feuchtner, G., Mirzaei, S., Weiss, K., Maroz-Vadalazhskaya, N., Gheysens, O., Homans, F., Moreno-Reyes, R., Pasquet, A., Roelants, V., Van De Heyning, C.M., Rios, R.A., Soldat-Stankovic, V., Stankovic, S., Albernaz Siqueira, M.H., Almeida, A., Alves Togni, P.H., Andrade, J.H., Andrade, L., Anselmi, C., Araujo, R., Azevedo, G., Bezerra, S., Biancardi, R., Grossman, G.B., Brandao, S., Pianta, D.B., Carreira, L., Castro, B., Chang, T., Cunali, F., Cury, R., Dantas, R., de Amorim Fernandes, F., De Lorenzo, A., De Macedo Filho, R., Erthal, F., Fernandes, F., Fernandes, J., De Souza, T.F., Alves, W.F., Ghini, B., Goncalves, L., Gottlieb, I., Hadlich, M., Kameoka, V., Lima, R., Lima, A., Lopes, R.W., Machado e Silva, R., Magalhaes, T., Silva, F.M., Mastrocola, L.E., Medeiros, F., Meneghetti, J.C., Naue, V., Naves, D., Nolasco, R., Nomura, C., Oliveira, J.B., Paixao, E., De Carvalho, F.P., Pinto, I., Possetti, P., Quinta, M., Nogueira Ramos, R.R., Rocha, R., Rodrigues, A., Rodrigues, C., Romantini, L., Sanches, A., Santana, S., Sara da Silva, L., Schvartzman, P., Matushita, C.S., Senra, T., Shiozaki, A., Menezes de Siqueira, M.E., Siqueira, C., Smanio, P., Soares, C.E., Junior, J.S., Bittencourt, M.S., Spiro, B., Mesquita, C.T., Torreao, J., Torres, R., Uellendahl, M., Monte, G.U., Verissimo, O., Cabeda, E.V., Pedras, F.V., Waltrick, R., Zapparoli, M., Naseer, H., Garcheva-Tsacheva, M., Kostadinova, I., Theng, Y., Abikhzer, G., Barette, R., Chow, B., Dabreo, D., Friedrich, M., Garg, R., Hafez, M.N., Johnson, C., Kiess, M., Leipsic, J., Leung, E., Miller, R., Oikonomou, A., Probst, S., Roifman, I., Small, G., Tandon, V., Trivedi, A., White, J., Zukotynski, K., Canessa, J., Munoz, G.C., Concha, C., Hidalgo, P., Lovera, C., Massardo, T., Vargas, L.S., Abad, P., Arturo, H., Ayala, S., Benitez, L., Cadena, A., Caicedo, C., Moncayo, A.C., Gomez, S., Gutierrez Villamil, C.T., Jaimes, C., Londono, J., Londono Blair, J.L., Pabon, L., Pineda, M., Rojas, J.C., Ruiz, D., Escobar, M.V., Vasquez, A., Vergel, D., Zuluaga, A., Gamboa, I.B., Castro, G., Gonzalez, U., Baric, A., Batinic, T., Franceschi, M., Paar, M.H., Jukic, M., Medakovic, P., Persic, V., Prpic, M., Punda, A., Batista, J.F., Gomez Lauchy, J.M., Gutierrez, Y.M., Menendez, R., Peix, A., Rochela, L., Panagidis, C., Petrou, I., Engelmann, V., Kaminek, M., Kincl, V., Lang, O., Simanek, M., Abdulla, J., Bottcher, M., Christensen, M., Gormsen, L.C., Hasbak, P., Hess, S., Holdgaard, P., Johansen, A., Kyhl, K., Norgaard, B.L., Ovrehus, K.A., Ronnow Sand, N.P., Steffensen, R., Thomassen, A., Zerahn, B., Perez, A., Escorza Velez, G.A., Velez, M.S., Abdel Aziz, I.S., Abougabal, M., Ahmed, T., Allam, A., Asfour, A., Hassan, M., Hassan, A., Ibrahim, A., Kaffas, S., Kandeel, A., Ali, M.M., Mansy, A., Maurice, H., Nabil, S., Shaaban, M., Flores, A.C., Poksi, A., Knuuti, J., Kokkonen, V., Larikka, M., Uusitalo, V., Bailly, M., Burg, S., Deux, J.-., Habouzit, V., Hyafil, F., Lairez, O., Proffit, F., Regaieg, H., Sarda-Mantel, L., Tacher, V., Schneider, R.P., Ayetey, H., Angelidis, G., Archontaki, A., Chatziioannou, S., Datseris, I., Fragkaki, C., Georgoulias, P., Koukouraki, S., Koutelou, M., Kyrozi, E., Repasos, E., Stavrou, P., Valsamaki, P., Gonzalez, C., Gutierrez, G., Maldonado, A., Buga, K., Garai, I., Maurovich-Horvat, P., Schmidt, E., Szilveszter, B., Varady, E., Banthia, N., Bhagat, J.K., Bhargava, R., Bhat, V., Choudhury, P., Chowdekar, V.S., Irodi, A., Jain, S., Joseph, E., Kumar, S., Girijanandan Mahapatra, P.D., Mitra, D., Mittal, B.R., Ozair, A., Patel, C., Patel, T., Patel, R., Patel, S., Saxena, S., Sengupta, S., Singh, S., Singh, B., Sood, A., Verma, A., Affandi, E., Alam, P.S., Edison, E., Gunawan, G., Hapkido, H., Hidayat, B., Huda, A., Mukti, A.P., Prawiro, D., Soeriadi, E.A., Syawaluddin, H., Albadr, A., Assadi, M., Emami, F., Houshmand, G., Maleki, M., Rostami, M.T., Zakavi, S.R., Zaid, E.A., Agranovich, S., Arnson, Y., Bar-Shalom, R., Frenkel, A., Knafo, G., Lugassi, R., Maor Moalem, I.S., Mor, M., Muskal, N., Ranser, S., Shalev, A., Albano, D., Alongi, P., Arnone, G., Bagatin, E., Baldari, S., Bauckneht, M., Bertelli, P., Bianco, F., Bonfiglioli, R., Boni, R., Bruno, A., Bruno, I., Busnardo, E., Califaretti, E., Camoni, L., Carnevale, A., Casoni, R., Cavallo, A.U., Cavenaghi, G., Chierichetti, F., Chiocchi, M., Cittanti, C., Colletta, M., Conti, U., Cossu, A., Cuocolo, A., Cuzzocrea, M., De Rimini, M.L., De Vincentis, G., Del Giudice, E., Del Torto, A., Della Tommasina, V., Durmo, R., Erba, P.A., Evangelista, L., Faletti, R., Faragasso, E., Farsad, M., Ferro, P., Florimonte, L., Frantellizzi, V., Fringuelli, F.M., Gatti, M., Gaudiano, A., Gimelli, A., Giubbini, R., Giuffrida, F., Ialuna, S., Laudicella, R., Leccisotti, L., Leva, L., Liga, R., Liguori, C., Longo, G., Maffione, M., Mancini, M.E., Marcassa, C., Milan, E., Nardi, B., Pacella, S., Pepe, G., Pontone, G., Pulizzi, S., Quartuccio, N., Rampin, L., Ricci, F., Rossini, P., Rubini, G., Russo, V., Sacchetti, G.M., Sambuceti, G., Scarano, M., Sciagra, R., Sperandio, M., Stefanelli, A., Ventroni, G., Zoboli, S., Baugh, D., Chambers, D., Madu, E., Nunura, F., Asano, H., Chimura, C.M., Fujimoto, S., Fujisue, K., Fukunaga, T., Fukushima, Y., Fukuyama, K., Hashimoto, J., Ichikawa, Y., Iguchi, N., Imai, M., Inaki, A., Ishimura, H., Isobe, S., Kadokami, T., Kato, T., Kumita, S., Maruno, H., Mataki, H., Miyagawa, M., Morimoto, R., Moroi, M., Nagamachi, S., Nakajima, K., Nakata, T., Nakazato, R., Nanasato, M., Naya, M., Norikane, T., Ohta, Y., Okayama, S., Okizaki, A., Otomi, Y., Otsuka, H., Saito, M., Sakata, S.Y., Sarai, M., Sato, D., Shiraishi, S., Suwa, Y., Takanami, K., Takehana, K., Taki, J., Tamaki, N., Taniguchi, Y., Teragawa, H., Tomizawa, N., Tsujita, K., Umeji, K., Wakabayashi, Y., Yamada, S., Yamazaki, S., Yoneyama, T., Rawashdeh, M., Batyrkhanov, D., Makhdomi, K., Ombati, K., Alkandari, F., Garashi, M., Coie, T.L., Rajvong, S., Kalinin, A., Kalnina, M., Haidar, M., Komiagiene, R., Kviecinskiene, G., Mataciunas, M., Vajauskas, D., Picard, C., Karim, N.K.A., Reichmuth, L., Samuel, A., Allarakha, M.A., Naojee, A.S., Alexanderson-Rosas, E., Barragan, E., Gonzalez-Montecinos, A.B., Cabada, M., Rodriguez, D.C., Carvajal-Juarez, I., Cortes, V., Cortes, F., De La Pena, E., Gama-Moreno, M., Gonzalez, L., Ramirez, N.G., Jimenez-Santos, M., Matos, L., Monroy, E., Morelos, M., Ornelas, M., Ortga Ramirez, J.A., Preciado-Anaya, A., Preciado-Gutierrez, O.U., Barragan, A.P., Rosales Uvera, S.G., Sandoval, S., Tomas, M.S., Sierra-Galan, L.M., Siu, S., Vallejo, E., Valles, M., Faraggi, M., Sereegotov, E., Ilic, S., Ben-Rais, N., Alaoui, N.I., Taleb, S., Pa Myo, K.P., Thu, P.S., Ghimire, R.K., Rajbanshi, B., Barneveld, P., Glaudemans, A., Habets, J., Koopmans, K.P., Manders, J., Pool, S., Scholte, A., Scholtens, A., Slart, R., Thimister, P., Van Asperen, E.-., Veltman, N., Verschure, D., Wagenaar, N., Edmond, J., Ellis, C., Johnson, K., Keenan, R., Kueh, S.H.A., Occleshaw, C., Sasse, A., To, A., Van Pelt, N., Young, C., Cuadra, T., Roque Vanegas, H.B., Soli, I.A., Issoufou, D.M., Ayodele, T., Madu, C., Onimode, Y., Efros-Monsen, E., Forsdahl, S.H., Hildre Dimmen, J.-., Jorgensen, A., Krohn, I., Lovhaugen, P., Braten, A.T., Al Dhuhli, H., Al Kindi, F., Al-Bulushi, N., Jawa, Z., Tag, N., Afzal, M.S., Fatima, S., Younis, M.N., Riaz, M., Saadullah, M., Herrera, Y., Lenturut-Katal, D., Vazquez, M.C., Ortellado, J., Akhter, A., Cao, D., Cheung, S., Dai, X., Gong, L., Han, D., Hou, Y., Li, C., Li, T., Li, D., Li, S., Liu, J., Liu, H., M. Y., N., Sun, K., Tang, G., Wang, J., Wang, X., Wang, Z.-., Wang, Y., Wu, J., Wu, Z., Xia, L., Xiao, J., Xu, L., Yang, Y., Yin, W., Yu, J., Yuan, L., Zhang, T., Zhang, L., Zhang, Y.-., Zhang, X., Zhu, L., Alfaro, A., Abrihan, P., Barroso, A., Cruz, E., Gomez, M.R., Magboo, V.P., Medina, J.M., Obaldo, J., Pastrana, D., Pawhay, C.M., Quinon, A., Tang, J.M., Tecson, B., Uson, K.J., Uy, M., Kostkiewicz, M., Kunikowska, J., Bettencourt, N., Cantinho, G., Ferreira, A., Syed, G., Arnous, S., Atyani, S., Byrne, A., Gleeson, T., Kerins, D., Meehan, C., Murphy, D., Murphy, M., Murray, J., O'Brien, J., Bang, J.-., Bom, H., Cho, S.-., Hong, C.M., Jang, S.J., Jeong, Y.H., Kang, W.J., Kim, J.-., Namgung, C.K., So, Y., Won, K.S., Majstorov, V., Vavlukis, M., Salobir, B.G., Stalc, M., Benedek, T., Benedek, I., Mititelu, R., Stan, C.A., Ansheles, A., Dariy, O., Drozdova, O., Gagarina, N., Gulyaev, V.M., Itskovich, I., Karalkin, A., Kokov, A., Migunova, E., Pospelov, V., Ryzhkova, D., Saifullina, G., Sazonova, S., Sergienko, V., Shurupova, I., Trifonova, T., Ussov, W.Y., Vakhromeeva, M., Valiullina, N., Zavadovsky, K., Zhuravlev, K., Okarvi, S., Saranovic, D.S., Keng, F., Jason See, J.H., Sekar, R., Yew, M.S., Vondrak, A., Bejai, S., Bennie, G., Bester, R., Engelbrecht, G., Evbuomwan, O., Gongxeka, H., Vuuren, M.J., Kaplan, M., Khushica, P., Lakhi, H., Louw, L., Malan, N., Milos, K., Modiselle, M., More, S., Naidoo, M., Scholtz, L., Vangu, M., Aguade-Bruix, S., Blanco, I., Cabrera, A., Camarero, A., Casans-Tormo, I., Cuellar-Calabria, H., Flotats, A., Fuentes Canamero, M.E., Garcia, M.E., Jimenez-Heffernan, A., Leta, R., Diaz, J.L., Lumbreras, L., Marquez-Cabeza, J.J., Martin, F., Martinez de Alegria, A., Medina, F., Canal, M.P., Peiro, V., Pubul-Nunez, V., Rayo Madrid, J.I., Rey, C.R., Perez, R.R., Ruiz, J., Hernandez, G.S., Sevilla, A., Zeidan, N., Nanayakkara, D., Udugama, C., Simonsson, M., Alkadhi, H., Buechel, R.R., Burger, P., Ceriani, L., De Boeck, B., Grani, C., Juillet de Saint Lager Lucas, A., Kamani, C.H., Kawel-Boehm, N., Manka, R., Prior, J.O., Rominger, A., Vallee, J.-., Khiewvan, B., Premprabha, T., Thientunyakit, T., Sellem, A., Kir, K.M., Sayman, H., Sebikali, M.J., Muyinda, Z., Kmetyuk, Y., Korol, P., Mykhalchenko, O., Pliatsek, V., Satyr, M., Albalooshi, B., Ahmed Hassan, M.I., Anderson, J., Bedi, P., Biggans, T., Bularga, A., Bull, R., Burgul, R., Carpenter, J.-., Coles, D., Cusack, D., Deshpande, A., Dougan, J., Fairbairn, T., Farrugia, A., Gopalan, D., Gummow, A., Ramkumar, P.G., Hamilton, M., Harbinson, M., Hartley, T., Hudson, B., Joshi, N., Kay, M., Kelion, A., Khokhar, A., Kitt, J., Low, C., Mak, S.M., Marousa, N., Martin, J., Mcalindon, E., Menezes, L., Morgan-Hughes, G., Moss, A., Murray, A., Nicol, E., Patel, D., Peebles, C., Pugliese, F., Luis Rodrigues, J.C., Rofe, C., Sabharwal, N., Schofield, R., Semple, T., Sharma, N., Strouhal, P., Subedi, D., Topping, W., Tweed, K., Weir-Mccall, J., Abbara, S., Abbasi, T., Abbott, B., Abohashem, S., Abramson, S., Al-Abboud, T., Al-Mallah, M., Almousalli, O., Ananthasubramaniam, K., Kumar, M.A., Askew, J., Attanasio, L., Balmer-Swain, M., Bayer, R.R., Bernheim, A., Bhatti, S., Bieging, E., Blankstein, R., Bloom, S., Blue, S., Bluemke, D., Borges, A., Branch, K., Bravo, P., Brothers, J., Budoff, M., Bullock-Palmer, R., Burandt, A., Burke, F.W., Bush, K., Candela, C., Capasso, E., Cavalcante, J., Chang, D., Chatterjee, S., Chatzizisis, Y., Cheezum, M., Chen, T., Chen, J., Chen, M., Clarcq, J., Cordero, A., Crim, M., Danciu, S., Decter, B., Dhruva, N., Doherty, N., Doukky, R., Dunbar, A., Duvall, W., Edwards, R., Esquitin, K., Farah, H., Fentanes, E., Ferencik, M., Fisher, D., Fitzpatrick, D., Foster, C., Fuisz, T., Gannon, M., Gastner, L., Gerson, M., Ghoshhajra, B., Goldberg, A., Goldner, B., Gonzalez, J., Gore, R., Gracia-Lopez, S., Hage, F., Haider, A., Haider, S., Hamirani, Y., Hassen, K., Hatfield, M., Hawkins, C., Hawthorne, K., Heath, N., Hendel, R., Hernandez, P., Hill, G., Horgan, S., Huffman, J., Hurwitz, L., Iskandrian, A., Janardhanan, R., Jellis, C., Jerome, S., Kalra, D., Kaviratne, S., Kay, F., Kelly, F., Khalique, O., Kinkhabwala, M., Iii, G.K., Kircher, J., Kirkbride, R., Kontos, M., Kottam, A., Krepp, J., Layer, J., Lee, S.H., Leppo, J., Lesser, J., Leung, S., Lewin, H., Litmanovich, D., Liu, Y., Magurany, K., Markowitz, J., Marn, A., Matis, S.E., Mckenna, M., Mcrae, T., Mendoza, F., Merhige, M., Min, D., Moffitt, C., Moncher, K., Moore, W., Morayati, S., Morris, M., Mossa-Basha, M., Mrsic, Z., Murthy, V., Nagpal, P., Napier, K., Nelson, K., Nijjar, P., Osman, M., Passen, E., Patel, A., Patil, P., Paul, R., Phillips, L., Polsani, V., Poludasu, R., Pomerantz, B., Porter, T., Prentice, R., Pursnani, A., Rabbat, M., Ramamurti, S., Rich, F., Luna, H.R., Robinson, A., Robles, K., Rodriguez, C., Rorie, M., Rumberger, J., Russell, R., Sabra, P., Sadler, D., Schemmer, M., Schoepf, U.J., Shah, S., Shah, N., Shanbhag, S., Sharma, G., Shayani, S., Shirani, J., Shivaram, P., Sigman, S., Simon, M., Slim, A., Smith, D., Smith, A., Soman, P., Srichai-Parsia, M.B., Streeter, J., T, A., Tawakol, A., Thomas, D., Thompson, R., Torbet, T., Trinidad, D., Ullery, S., Unzek, S., Uretsky, S., Vallurupalli, S., Verma, V., Waller, A., Wang, E., Ward, P., Weissman, G., Wesbey, G., White, K., Winchester, D., Wolinsky, D., Yost, S., Zgaljardic, M., Alonso, O., Beretta, M., Ferrando, R., Kapitan, M., Mut, F., Djuraev, O., Rozikhodjaeva, G., Le Ngoc, H., Mai, S.H., and Nguyen, X.C.

Subjects
INCAPS COVID Investigators Group, Pediatric Research Initiative, positron emission tomography, CTA, SARS-CoV-2, cardiac testing, invasive coronary angiography, Prevention, coronavirus, coronavirus disease-19, COVID-19, global health, Settore MED/11 - Malattie dell'Apparato Cardiovascolare, cardiac magnetic resonance, cardiovascular disease, NO, transthoracic echocardiography, PET, Good Health and Well Being, severe acute respiratory syndrome-coronavirus-2, TTE, ICA, CMR, computed tomographic angiography
Abstract

BackgroundThe coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known.ObjectivesThis study sought to evaluate the effects of the early phase of the COVID-19 pandemic on cardiovascular diagnostic procedures and safety practices in Asia.MethodsThe International Atomic Energy Agency conducted a worldwide survey to assess changes in cardiovascular procedure volume and safety practices caused by COVID-19. Testing volumes were reported for March 2020 and April 2020 and were compared to those from March 2019. Data from 180 centers across 33 Asian countries were grouped into 4 subregions for comparison.ResultsProcedure volumes decreased by 47% from March 2019 to March 2020, showing recovery from March 2020 to April 2020 in Eastern Asia, particularly in China. The majority of centers cancelled outpatient activities and increased time per study. Practice changes included implementing physical distancing and restricting visitors. Although COVID testing was not commonly performed, it was conducted in one-third of facilities in Eastern Asia. The most severe reductions in procedure volumes were observed in lower-income countries, where volumes decreased 81% from March 2019 to April2020.ConclusionsThe COVID-19 pandemic in Asia caused significant reductions in cardiovascular diagnostic procedures, particularly in low-income countries. Further studies on effects of COVID-19 on cardiovascular outcomes and changes in care delivery are warranted.

Published
2021

23. Prognostic implications of a novel algorithm to grade secondary tricuspid regurgitation

Author

Fortuni, F., Dietz, M.F., Prihadi, E.A., Bijl, P. van der, Ferrari, G.M. de, Knuuti, J., Bax, J.J., Delgado, V., and Marsan, N.A.

Subjects
prognosis, right ventricle, tricuspid regurgitation
Abstract

OBJECTIVES A novel tricuspid regurgitation (TR) grading system, using vena contracta (VC) width and effective regurgitant orifice area (EROA), was proposed and validated based on its prognostic usefulness.BACKGROUND The clinical need of a new grading system for TR has recently been emphasized to depict the whole spectrum of TR severity, particularly beyond severe TR (massive or torrential).METHODS TR severity was characterized in 1,129 patients with moderate or severe secondary TR (STR). Recently proposed cutoff values of VC width were more effective in differentiating the prognosis of patients with moderate STR, whereas EROA cutoff values performed better in characterizing the risk of patients with more severe STR. Therefore, these 2 parameters were combined into a novel grading system to define moderate (VC = 7 mm and EROA = 7 mm and EROA >= 80 mm(2)) STR.RESULTS A total of 143 patients (13%) showed moderate STR, whereas 536 patients (47%) had severe STR, and 450 (40%) had torrential STR. Patients with torrential STR had larger right ventricular (RV) dimensions, lower RV systolic function, and were more likely to receive diuretics. The cumulative 10-year survival rate was 53% for moderate, 45% for severe, and 35% for torrential STR (p = 0.007). After adjusting for potential confounders, torrential STR retained an association with worse prognosis compared with other STR grades (hazard ratio: 1.245; 95% confidence interval: 1.023 to 1.516; p = 0.029).CONCLUSIONS A novel STR grading system was able to capture the whole range of STR severity and identified patients with torrential STR who were characterized by a worse prognosis. (C) 2021 by the American College of Cardiology Foundation.

Published
2020

24. 2019 ESC Guide on the Diagnosis and Treatment of Chronic Coronary Syndromes

Author

Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R.F., Deaton, C., Cuisset, T., Agewall, S., Dickstein, K., Edvardsen, T., Escaned, J., Gersh, B.J., Svitil, P., Gilard, M., Hasdai, D., Hatala, R., Mahfoud, F., Masip, J., Muneretto, C., Valgimigli, M., Achenbach, S., Bax, J.J., and Soc Europea Cardiologia ESC Diagno

Published
2020

25. Pilot study of the multicentre DISCHARGE trial

Author

Rubeis, G. de, Napp, A.E., Schlattmann, P., Geleijns, J., Laule, M., Dreger, H., Kofoed, K., Sorgaard, M., Engstrom, T., Tilsted, H.H., Boi, A., Porcu, M., Cossa, S., Rodriguez-Palomares, J.F., Valente, F.X., Roque, A., Feuchtner, G., Plank, F., Stechovsky, C., Adla, T., Schroeder, S., Zelesny, T., Gutberlet, M., Woinke, M., Karolyi, M., Karady, J., Donnelly, P., Ball, P., Dodd, J.D., Hensey, M., Mancone, M., Ceccacci, A., Berzina, M., Zvaigzne, L., Sakalyte, G., Basevicius, A., Ilnicka-Suckiel, M., Kusmierz, D., Faria, R., Gama-Ribeiro, V., Benedek, I., Benedek, T., Adjic, F., Cankovic, M., Berry, C., Delles, C., Thwaite, E., Davis, G., Knuuti, J., Pietila, M., Kepka, C., Kruk, M., Vidakovic, R., Neskovic, A.N., Lecumberri, I., Gonzales, I.D., Ruzsics, B., Fisher, M., Dewey, M., Francone, M., and DISCHARGE Trial Grp

Abstract

The original version of this article, published on 16 December 2019, unfortunately contained two mistakes.

Published
2020

26. Therapeutic antibody against phosphorylcholine preserves coronary function and attenuates vascular F-18-FDG uptake in atherosclerotic mice

Author

Stahle, M., Silvola, J.M.U., Hellberg, S., Vries, M. de, Quax, P.H.A., Kroon, J., Rinne, P., Jong, A. de, Liljenback, H., Savisto, N., Wickman, A., Stroes, E.S.G., Yla-Herttuala, S., Saukko, P., Abrahamsson, T., Pettersson, K., Knuuti, J., Roivainen, A., and Saraste, A.

Subjects
phosphorylcholine, coronary flow reserve, inflammation, atherosclerosis, F-18-fluorodeozyglucose positron emission tomography
Abstract

This study showed that treatment with a therapeutic monoclonal immunoglobutin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of F-18-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies. (C) 2020 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

Published
2020

27. Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography

Author

Rubeis, G. de, Napp, A.E., Schlattmann, P., Geleijns, J., Laule, M., Dreger, H., Kofoed, K., Sorgaard, M., Engstrom, T., Tilsted, H.H., Boi, A., Porcu, M., Cossa, S., Rodriguez-Palomares, J.F., Valente, F.X., Roque, A., Feuchtner, G., Plank, F., Stechovsky, C., Adla, T., Schroeder, S., Zelesny, T., Gutberlet, M., Woinke, M., Karolyi, M., Karady, J., Donnelly, P., Ball, P., Dodd, J., Hensey, M., Mancone, M., Ceccacci, A., Berzina, M., Zvaigzne, L., Sakalyte, G., Basevicius, A., Ilnicka-Suckiel, M., Kusmierz, D., Faria, R., Gama-Ribeiro, V., Benedek, I., Benedek, T., Adjic, F., Cankovic, M., Berry, C., Delles, C., Thwaite, E., Davis, G., Knuuti, J., Pietila, M., Kepka, C., Kruk, M., Vidakovic, R., Neskovic, A.N., Lecumberri, I., Gonzales, I.D., Ruzsics, B., Fisher, M., Dewey, M., Francone, M., and DISCHARGE Trial Grp

Subjects
Male, medicine.medical_specialty, Computed Tomography Angiography, Image quality, Pilot Projects, Computed tomography, Coronary Angiography, Coronary artery disease, angiography, coronary, coronary artery disease, CT angiography, medical imaging, trial protocols, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Medical imaging, Humans, Radiology, Nuclear Medicine and imaging, Neuroradiology, Protocol (science), medicine.diagnostic_test, business.industry, Angiography, Reproducibility of Results, Interventional radiology, General Medicine, Middle Aged, medicine.disease, Coronary Vessels, Invasive coronary angiography, 030220 oncology & carcinogenesis, Trial protocols, Female, Radiology, business
Abstract

To implement detailed EU cardiac computed tomography angiography (CCTA) quality criteria in the multicentre DISCHARGE trial (FP72007-2013, EC-GA 603266), we reviewed image quality and adherence to CCTA protocol and to the recommendations of invasive coronary angiography (ICA) in a pilot study.From every clinical centre, imaging datasets of three patients per arm were assessed for adherence to the inclusion/exclusion criteria of the pilot study, predefined standards for the CCTA protocol and ICA recommendations, image quality and non-diagnostic (NDX) rate. These parameters were compared via multinomial regression and ANOVA. If a site did not reach the minimum quality level, additional datasets had to be sent before entering into the final accepted database (FADB).We analysed 226 cases (150 CCTA/76 ICA). The inclusion/exclusion criteria were not met by 6 of the 226 (2.7%) datasets. The predefined standard was not met by 13 of 76 ICA datasets (17.1%). This percentage decreased between the initial CCTA database and the FADB (multinomial regression, 53 of 70 vs 17 of 75 [76%] vs [23%]). The signal-to-noise ratio and contrast-to-noise ratio of the FADB did not improve significantly (ANOVA, p = 0.20; p = 0.09). The CTA NDX rate was reduced, but not significantly (initial CCTA database 15 of 70 [21.4%]) and FADB 9 of 75 [12%]; p = 0.13).We were able to increase conformity to the inclusion/exclusion criteria and CCTA protocol, improve image quality and decrease the CCTA NDX rate by implementing EU CCTA quality criteria and ICA recommendations.• Failure to meet protocol adherence in cardiac CTA was high in the pilot study (77.6%). • Image quality varies between sites and can be improved by feedback given by the core lab. • Conformance with new EU cardiac CT quality criteria might render cardiac CTA findings more consistent and comparable.

Published
2020

29. Correction to: Pilot study of the multicentre DISCHARGE trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography

Author

De Rubeis, G., Napp, A. E., Schlattmann, P., Geleijns, J., Laule, M., Dreger, H., Kofoed, K., Sorgaard, M., Engstrom, T., Tilsted, H. H., Boi, A., Porcu, M., Cossa, S., Rodriguez-Palomares, J. F., Valente, F. X., Roque, A., Feuchtner, G., Plank, F., Stechovsky, C., Adla, T., Schroeder, S., Zelesny, T., Gutberlet, M., Woinke, M., Karolyi, M., Karady, J., Donnelly, P., Ball, P., Dodd, J. D., Hensey, M., Mancone, M., Ceccacci, A., Berzina, M., Zvaigzne, L., Sakalyte, G., Basevicius, A., Ilnicka-Suckiel, M., Kusmierz, D., Faria, R., Gama-Ribeiro, V., Benedek, I., Benedek, T., Adjic, F., Cankovic, M., Berry, C., Delles, C., Thwaite, E., Davis, G., Knuuti, J., Pietila, M., Kepka, C., Kruk, M., Vidakovic, R., Neskovic, A. N., Lecumberri, I., Gonzales, I. D., Ruzsics, B., Fisher, M., Dewey, M., and Francone, M.

Subjects
TAVI, CT, MR, Radiology, Nuclear Medicine and imaging, General Medicine
Published
2020

36. Posters display III clinical outcome and PET

Author

Baliño, N. Nestor Perez, Masoli, O., Traverso, S., Grynberg, L., Rappallo, C., Redruello, M., Rosa, D., Cragnolino, D., Meretta, A., Vidal, L., Graf, S., Khorsand, A. Aliasghar, Gyongyosi, M., Karanikas, G., Eidherr, H., Kletter, K., Porenta, G., Glogar, D., Sochor, H., Beheshti, M., Poetzi, C., Wadsak, W., Porenta, G., Maurer, G., Wolfram, J., Winter, O. Olivier De, Velghe, A., Veire, N. Van de, Bondt, P. De, Buyzere, M. De, Wiele, C. Van de, Backer, G. De, Gillebert, T. C., Dierckx, R. A., Sutter, J. De, Bernard, D., Langlois, M., Duarte, P. S. Paulo, Mastrocolla, L. E., Sampaio, C. R. E., Rossi, J. M., Smanio, P. E., Lima, E. V., Oliveira, C. A. R., Pereira, J. C. R., Smanio, P. Paola, Beraldo, P., Rodrigues, F., Thom, A., Yoshinaga, K. Keiichiro, Ukkonen, H., Burwash, I., DeKemp, R., Dafoe, W., Davies, R., Haddad, H., Ruddy, T., DaSilva, J., Beanlands, R., Chow, B., Williams, K., Garrard, L., Szeto, A., Aung, M., Sondergaard, H. Hanne, Bottcher, M., Madsen, M. M., Schmitz, O., Nielsen, T. T., Botker, H. E., Høilund-Carlsen, P. F. Poul F., Johansen, A., Christensen, H. W., Vach, W., Møldrup, M., Haghfelt, T., Johansen, A. Allan, Høilund-Carlsen, P. F., Christensen, H. W., Møldrup, M., Kristensen, J. Jens Hedega, Maeng, M., Mortensen, U. M., Berg, J. S., Rehling, M., Nielsen, T. T., Elsaban, K. Khaled, El-Kady, T., El-Gabaly, M., Yehia, A., El-Sayed, M., Naum, A. Alexandru, Laaksonen, M. S., Tuunanen, H., Oikonen, V., Kemppainen, J., Järvisalo, M. J., Nuutila, P., Knuuti, J., Vanzetto, G. Gerald, Jacon, P., Fagret, D., Machecourt, J., Lindner, O. Oliver, Vogt, J., Kammeier, A., Fricke, E., Wielepp, P., Baller, D., Lamp, B., Holzinger, J., Horstkotte, D., Burchert, W., Nekolla, S. G. Stephan, Souvatzoglou, M., Hausleiter, J., Henke, N., Kruschke, K., Bengel, F., Schwaiger, M., Sundaram, P. S. Palaniswamy Shanmuga, Padma, S., Haridas, K. K., Kumar, S., Zachariah, M., Livschitz, S. Shay, Zornitzki, T., Vered, S., Oettinger, M., Levy, R., Caspi, A., Faraggi, D., Knobler, H., Mats, I., Solodky, A., Ben-Gal, T., Battler, A., Zafrir, N. Nili, Varani, E. Elisabetta, Balducelli, M., Severi, S., Patroncini, A. L., Vecchi, G., Gatti, C., Corbelli, C., Casanova, R., Maresta, A., Cittanti, C. Corrado, Valgimigli, M., Giganti, M., Malagutti, P., Percoco, G., Bagatin, E., Panareo, S., Avigni, N., Ferrari, R., Feggi, L., Filardi, P. Pasquale Perrone, Cuocolo, A., Storto, G., Brevetti, G., Dellegrottaglie, S., Corrado, L., Cafiero, M., Polimeno, M., Zarrilli, A., Chiariello, M., Marcassa, C. Claudio, Campini, R., Calza, P., Giannuzzi, P., Galassi, A. R. Alfredo, Grasso, C., Azzarelli, S., Leotta, E., Moshiri, S., Tamburino, C., Acampa, W., Ferro, A., Petretta, M., Salvatore, M., Cuocolo, A. Alberto, Pieri, P. L. Pierluigi, Berta, R., Moscatelli, G., Buccoliero, F., Inglese, E., Marcassa, C. Claudio, Medolago, G., Imperiale, A., Rimini, M. L. De, Bertagna, F., Sullo, P., Lupo, M., Cappagli, M., Fukuda, H. Hiroshi, Kunimasa, T., Furuhashi, T., Moroi, M., Yasuhi, W. Watanabe, Akihiro, S., Akio, Y., Ryou, K., Kimio, T., Yasunori, W., Yasuhiko, T., Nariaki, E., Watabe, H. Hiroshi, Teramoto, N., Ohta, Y., Kou, Y., Hayashi, T., Iida, H., Bom, H. S. Hee-Seung, Song, H. C., Min, J. J., Heo, Y. J., Seo, J. H., Lee, J. Jae-Tae, Bae, J. H., Jeong, S. Y., Ahn, B. C., Chae, S. C., Lee, K. B., Popiel, M. Malgorzata, Grajek, S., Czepczynski, R., Breborowicz, P., Lesiak, M., Czyz, A., Sawinski, K., Komarnicki, M., Cieslinski, A., Sowinski, J., Ferreira, A. António, Ventosa, A., Gil, V., Calqueiro, J., Lima, S., Aguiar, C., Couto, R., Raposo, L., Seabra-Gomes, R., Vasconcelos, M. Mariana, Martins, E., Faria, T., Oliveira, A., Garcia, M., Pereira, J., Rocha-Gonçalves, F., Lourenço, C. Cândida, Roque, C., Ferrer-Antunes, A., Ferreira, M., Providência, L. A., Lima, J., Medrea, C. Claudia, Bogdan, R., Lazar, A., Mot, S., Capilneanu, R., Kozulin, V. Vickenty, Berkovich, O., Ivashchenko, T., Larionova, V., Esipovich, I., Gordeev, M., Panov, A., Shlyakhto, E., Burova, N., Baranov, D., Timoshin, V., Chuprova, S., Shkolnikova, M., Zaklyazminskaya, E., Poliakov, A., Sazonova, S. Svetlana, Romero-Farina, G., Arenillas, J. F., Candell-Riera, J., Aguadè-Bruix, S. Santiago, Leon, G. De, Molina, C. A., Chacon, P., Montaner, J., Rovira, A., Alvarez-Sabin, J., Namdar, M. Mehdi, Siegrist, P. T., Grathwohl, R., Delaloye, R., Koepfli, P., Wyss, C. A., Kaufmann, P. A., Bartenstein, N., Hellermann, J., Siegrist, P. T. Patrick, Namdar, M., Pollack, C., Schurr, U., Kaufmann, P. A., Zellweger, M. J. Michael, Burger, P. C., Mueller-Brand, J., Pfisterer, M. E., Gordon, L. Leonie, Epps, A., Chiarameda, S., Navare, S. Sachin, Ahlberg, A., Cyr, G., Katten, D., Ausef, A., Heller, G., Darrow, B. Bruce, Thomas, G. S. Gregory, Ip, T. K., Thompson, R. C., Kramer, D. B., Rice, D. L., Thomas, J. J., Miyamoto, M. I., Druz, R. S. Regina, Nichols, K. J., Akinboboye, O. O., Reichek, N., Podrasky, E. Ernest, Tuttle, R. T. Robert, Shaw, L. S. Linda, Hanson, M. W. H. Michael, Borges-Neto, S. Salvador, Lundbye, J. Justin, Werden, S., Kazi, F., Whalen, A., Noble, G. L., O’Sullivan, D., Boden, W. E., Heller, G. V., Ausef, A. Amir, Ahlberg, A. W., Danias, P. G., Papaioannou, G. I., Leka, I. A., Boden, W. E., Heller, G. V., Beretta, M. Mario, Viňas, S., Gonzalez, A., Vidal, I., and Rener, A.

Published
2005
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48. Characterization of functionally significant coronary artery disease by a coronary computed tomography angiography-based index: A comparison with positron emission tomography

Author

Anagnostopoulos, C.D. Siogkas, P.K. Liga, R. Benetos, G. Maaniitty, T. Sakellarios, A.I. Koutagiar, I. Karakitsios, I. Papafaklis, M.I. Berti, V. Sciagrà, R. Scholte, A.J.H.A. Michalis, L.K. Gaemperli, O. Kaufmann, P.A. Pelosi, G. Parodi, O. Knuuti, J. Fotiadis, D.I. Neglia, D.

Abstract

To test the hypothesis that virtual functional assessment index (vFAI) is related with regional flow parameters derived by quantitative positron emission tomography (PET) and can be used to assess abnormal vasodilating capability in coronary vessels with stenotic lesions at coronary computed tomography angiography (CCTA). Methods and results: vFAI, stress myocardial blood flow (MBF), and myocardial flow reserve (MFR) were assessed in 78 patients (mean age 62.2 ± 7.7 years) with intermediate pre-test likelihood of coronary artery disease (CAD). Coronary stenoses ≥50% were considered angiographically significant. PET was considered positive for significant CAD, when more than one contiguous segments showed stress MBF ≤2.3 mL/g/min for O-water or

Published
2019

49. Molecular imaging to monitor left ventricular remodeling in heart failure

Author

Ylä-Herttuala, E. (Elias), Saraste, A. (Antti), Knuuti, J. (Juhani), Liimatainen, T. (Timo), and Ylä-Herttuala, S. (Seppo)

Subjects
PET, Infarction, Myocardium, SPECT, Hyperpolarized MRI, MRI
Abstract

Purpose of Review: Cardiovascular diseases are the leading cause of deaths worldwide. Many complex cellular and molecular pathways lead to myocardial remodeling after ischemic insults. Anatomy, function, and viability of the myocardium can be assessed by modern medical imaging techniques by both visualizing and quantifying damages. Novel imaging techniques aim for a precise and accurate visualization of the myocardium and for the detection of alternations at the molecular level. Recent Findings: Magnetic resonance imaging assesses anatomy, function, and tissue characterization of the myocardium non-invasively with high spatial resolution, sensitivity, and specificity. Using hyperpolarized magnetic resonance imaging, molecular and metabolic conditions can be assessed non-invasively. Single photon-emission tomography and positron-emission tomography are the most sensitive techniques to detect biological processes in the myocardium. Cardiac perfusion, metabolism, and viability are the most common clinical targets. In addition, molecular-targeted imaging of biological processes involved in heart failure, such as myocardial innervation, inflammation, and extracellular matrix remodeling, is feasible. Summary: Novel imaging techniques can provide a precise and accurate visualization of the myocardium and for the detection of alternations at molecular level.

Published
2019

50. Amyloid-targeting PET tracer [¹⁸F]Flutemetamol accumulates in atherosclerotic plaques

Author

Hellberg, S. (Sanna), Silvola, J. M. (Johanna M.U.), Liljenbäck, H. (Heidi), Kiugel, M. (Max), Eskola, O. (Olli), Hakovirta, H. (Harri), Hörkkö, S. (Sohvi), Morisson-Iveson, V. (Veronique), Hirani, E. (Ella), Saukko, P. (Pekka), Ylä-Herttuala, S. (Seppo), Knuuti, J. (Juhani), Saraste, A. (Antti), and Roivainen, A. (Anne)

Subjects
atherosclerolis, autodiography, positron emission tomography, amyloid, imaging
Abstract

Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, and different amyloid species have recently been recognized in atherosclerotic plaques. Therefore, we studied the uptake of the amyloid imaging agent [¹⁸F]Flutemetamol in atherosclerotic plaques. The binding of [¹⁸F]Flutemetamol to human carotid artery plaque was studied in vitro. In vivo uptake of the tracer was studied in hypercholesterolemic IGF-II/LDLR⁻/⁻ApoB¹⁰⁰/¹⁰⁰ mice and C57BL/6N controls. Tracer biodistribution was studied in vivo with PET/CT, and ex vivo by gamma counter and digital ex vivo autoradiography. The presence of amyloid, ox-LDL, and macrophages in the plaques was examined by immunohistochemistry. [¹⁸F]Flutemetamol showed specific accumulation in human carotid plaque, especially in areas positive for amyloid beta. The aortas of IGF-II/LDLR⁻/⁻ApoB¹⁰⁰/¹⁰⁰ mice showed large thioflavin-S-positive atherosclerotic plaques containing ox-LDL and macrophages. Autoradiography revealed 1.7-fold higher uptake in the plaques than in a lesion-free vessel wall, but no difference in aortic tissue uptake between mouse strains were observed in the in vivo PET/CT. In conclusion, [¹⁸F]Flutemetamol binds to amyloid-positive areas in human atherosclerotic plaques. Further studies are warranted to clarify the uptake mechanisms, and the potential of the tracer for in vivo imaging of atherosclerosis in patients.

Published
2019

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