Characterization of functionally significant coronary artery disease by a coronary computed tomography angiography-based index: A comparison with positron emission tomography

Authors :: Anagnostopoulos, C.D. Siogkas, P.K. Liga, R. Benetos, G. Maaniitty, T. Sakellarios, A.I. Koutagiar, I. Karakitsios, I. Papafaklis, M.I. Berti, V. Sciagrà, R. Scholte, A.J.H.A. Michalis, L.K. Gaemperli, O. Kaufmann, P.A. Pelosi, G. Parodi, O. Knuuti, J. Fotiadis, D.I. Neglia, D.
Publication Year :: 2019
Abstract: To test the hypothesis that virtual functional assessment index (vFAI) is related with regional flow parameters derived by quantitative positron emission tomography (PET) and can be used to assess abnormal vasodilating capability in coronary vessels with stenotic lesions at coronary computed tomography angiography (CCTA). Methods and results: vFAI, stress myocardial blood flow (MBF), and myocardial flow reserve (MFR) were assessed in 78 patients (mean age 62.2 ± 7.7 years) with intermediate pre-test likelihood of coronary artery disease (CAD). Coronary stenoses ≥50% were considered angiographically significant. PET was considered positive for significant CAD, when more than one contiguous segments showed stress MBF ≤2.3 mL/g/min for O-water or

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