17 results on '"Kim, Hui-Hun"'
Search Results
2. Perfluorooctanoic acid induces mast cell-mediated allergic inflammation by the release of histamine and inflammatory mediators
- Author
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Singh, Thoudam S.K., Lee, Soyoung, Kim, Hui-Hun, Choi, Jin Kyeong, and Kim, Sang-Hyun
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- 2012
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3. A new neolignan and lignans from the stems of Lindera obtusiloba Blume and their anti-allergic inflammatory effects
- Author
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Choi, Hyun Gyu, Choi, Yeon Ho, Kim, Ji Hyang, Kim, Hui-Hun, Kim, Sang-Hyun, Kim, Jeong Ah, Lee, Sang Myung, Na, MinKyun, and Lee, Seung Ho
- Published
- 2014
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4. Inhibitory effect of 1,2,4,5-tetramethoxybenzene on mast cell-mediated allergic inflammation through suppression of IκB kinase complex
- Author
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Je, In-Gyu, Choi, Hyun Gyu, Kim, Hui-Hun, Lee, Soyoung, Choi, Jin Kyeong, Kim, Sung-Wan, Kim, Duk-Sil, Kwon, Taeg Kyu, Shin, Tae-Yong, Park, Pil-Hoon, Khang, Dongwoo, and Kim, Sang-Hyun
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- 2015
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5. Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation
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Kim, Hui-Hun, Park, Seung-Bin, Lee, Soyoung, Kyu Kwon, Taeg, Shin, Tae-Yong, Park, Pil-Hoon, Lee, Seung-Ho, and Kim, Sang-Hyun
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- 2014
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6. SG-HQ2 inhibits mast cell-mediated allergic inflammation through suppression of histamine release and pro-inflammatory cytokines.
- Author
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Je, In-Gyu, Kim, Hui-Hun, Park, Pil-Hoon, Kwon, Taeg Kyu, Seo, Seung-Yong, Shin, Tae-Yong, and Kim, Sang-Hyun
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- 2015
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7. Galangin attenuates mast cell-mediated allergic inflammation.
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Kim, Hui-Hun, Bae, Yunju, and Kim, Sang-Hyun
- Subjects
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FLAVONOLS , *MAST cells , *DRUG development , *INFLAMMATION treatment , *ALLERGIES , *CYTOKINES , *GENE expression , *TUMOR necrosis factors - Abstract
Highlights: [•] Discovery of drugs for the allergic inflammation is important in human health. [•] Galangin is a natural flavonoid contained in propolis, vegetable and fruits. [•] Galangin decreased inflammatory cytokines through the inhibition of NF-κB. [•] Galangin inhibited local hypersensitivity, and the expression of H1R. [•] Galangin might be a candidate for the treatment of allergic inflammatory diseases. [Copyright &y& Elsevier]
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- 2013
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8. Aqueous Extract of Mosla chinensis Inhibits Mast Cell-Mediated Allergic Inflammation.
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Kim, Hui-Hun, Yoo, Jin-Su, Shin, Tae-Yong, and Kim, Sang-Hyun
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ALLERGY drug therapy , *ANAPHYLAXIS , *ANIMAL experimentation , *BIOLOGICAL assay , *CELL culture , *DOSE-effect relationship in pharmacology , *ENZYME-linked immunosorbent assay , *GENE expression , *HISTAMINE , *INFLAMMATION , *INTERLEUKINS , *MAST cells , *MICE , *POLYMERASE chain reaction , *RESEARCH funding , *STATISTICS , *TUMOR necrosis factors , *WESTERN immunoblotting , *PLANT extracts , *DATA analysis , *REVERSE transcriptase polymerase chain reaction , *DATA analysis software , *DESCRIPTIVE statistics - Abstract
Allergic inflammatory diseases such as food allergy, asthma, sinusitis, and atopic dermatitis are increasing worldwide. In this study, we investigated the effects of aqueous extract of Mosla chinensis Max. (AMC) on mast cell-mediated allergic inflammation and studied the possible mechanism of this action. AMC inhibited compound 48/80-induced systemic and immunoglobulin E (IgE)-mediated local anaphylaxis. AMC reduced intracellular calcium levels and downstream histamine release from rat peritoneal mast cells activated by compound 48/80 or IgE. In addition, AMC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-8 in human mast cells. The inhibitory effect of AMC on cytokine expression was nuclear factor (NF)-κB dependent. Our results indicate that AMC inhibits mast cell-mediated allergic inflammatory reaction by suppressing histamine release and expression of proinflammatory cytokines and the involvement of calcium and NF-κB in these effects. AMC might be a possible therapeutic candidate for allergic inflammatory disorders. [ABSTRACT FROM AUTHOR]
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- 2012
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9. Suppression of dust mite extract and 2,4-dinitrochlorobenzene-induced atopic dermatitis by the water extract of Lindera obtusiloba
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Choi, Eun-Ju, Lee, Soyoung, Kim, Hui-Hun, Singh, Thoudam S.K., Choi, Jin Kyeong, Choi, Hyun Gyu, Suh, Won Mo, Lee, Seung-Ho, and Kim, Sang-Hyun
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ATOPIC dermatitis , *ALTERNATIVE medicine , *ANALYSIS of variance , *ANIMAL experimentation , *BIOPHYSICS , *EAR , *EPIDERMIS , *GENES , *HISTAMINE , *IMMUNOGLOBULINS , *INTERLEUKINS , *MAST cells , *RESEARCH methodology , *MEDICINAL plants , *MICE , *MITES , *CUTANEOUS therapeutics , *TUMOR necrosis factors , *PLANT extracts , *PREVENTION - Abstract
Abstract: Ethnopharmacological relevance: The Lindera obtusiloba has been used in traditional medicine for the treatment of inflammation and dermatitis. In this study, we investigated the effect of topical application of Lindera obtusiloba water extract (LOWE) on the house dust mite extract (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Materials and methods: We established AD model in BALB/c mice by repeated local exposure of DFE/DNCB to the ears. After a topical application of LOWE on the skin lesions, the epidermal thickness, mast cell infiltration, and serum immunoglobulin E (IgE) and histamine were measured. In addition, the gene expression of interleukin (IL)-4, IL-13, IL-31, and tumor necrosis factor (TNF)-α in the ears was assayed. Results: LOWE reduced AD symptoms based on ear thickness, histopathological analysis, and serum IgE levels. LOWE inhibited mast cell infiltration into the ear and elevation of serum histamine in AD model. Moreover, LOWE suppressed DFE/DNCB-induced expression of IL-4, IL-13, IL-31, and TNF-α in the ears. Conclusions: Our results showed that topical application of LOWE exerts beneficial effects in AD symptoms, suggesting that LOWE might be a candidate for the treatment of AD. [Copyright &y& Elsevier]
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- 2011
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10. Free-Standing NiS₂ Electrode as High-Rate Anode Material for Sodium-Ion Batteries.
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Sadan MK, Kim HH, Kim C, Cho GB, Reddy NS, Cho KK, Nam TH, Kim KW, Ahn JH, and Ahn HJ
- Abstract
Owing to the speculated price hike and scarcity of lithium resources, sodium-ion batteries are attracting significant research interest these days. However, sodium-ion battery anodes do not deliver good electrochemical performance, particularly rate performance. Herein, we report the facile electrospinning synthesis of a free-standing nickel disulfide (NiS²) embedded on carbon nanofiber. This electrode did not require a conducting agent, current collector, and binder, and typically delivered high capacity and rate performance. The electrode delivered a high initial capacity of 603 mAh g
-1 at the current density of 500 mA g-1 . Moreover, the electrode delivered the capacity of 271 mAh g-1 at the high current density of 15 A g-1 . The excellent rate performance and high coulombic efficiency of the electrode were attributed to its low charge transfer resistance and unique structure.- Published
- 2020
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11. Inhibitory effects of Diospyros kaki in a model of allergic inflammation: role of cAMP, calcium and nuclear factor-κB.
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Kim HH, Kim DS, Kim SW, Lim SH, Kim DK, Shin TY, and Kim SH
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- Animals, Anti-Asthmatic Agents pharmacology, Cell Line, Cromolyn Sodium pharmacology, Disease Models, Animal, Histamine Release drug effects, Humans, Hypersensitivity drug therapy, Interleukin-1beta genetics, Interleukin-1beta metabolism, Interleukin-6 genetics, Interleukin-6 metabolism, Male, Mast Cells drug effects, Mast Cells metabolism, Mice, Mice, Inbred ICR, NF-kappa B antagonists & inhibitors, NF-kappa B genetics, NF-kappa B metabolism, Tumor Necrosis Factor-alpha genetics, Tumor Necrosis Factor-alpha metabolism, Calcium metabolism, Diospyros chemistry, Inflammation drug therapy, Plant Extracts pharmacology
- Abstract
Diospyros kaki (D. kaki) has been cultivated throughout Eastern Asia for hundreds of years. D. kaki contains various biological active compounds, such as amino acids, carotenoids, flavonoids, tannins, catechins and vitamin A. Previous studies have shown that D. kaki has beneficial effects on homeostasis, constipation, hypertension, atherosclerosis and allergic dermatitis and is a good source of antioxidants, polyphenols and dietary fiber. However, the anti-allergic and anti-inflammatory effects of D. kaki have not yet been elucidated. This study aimed to investigate the protective effects of the aqueous extract of Diospyros kaki (AEDK) on mast cell-mediated allergic inflammation and to determine its possible mechanisms of action by using in vitro and in vivo mast cell-based models. The cAMP and intracellular calcium levels were measured to clarify the mechanisms by which AEDK inhibits the release of histamine from mast cells. AEDK inhibited the release of histamine and β-hexosaminidase from mast cells by modulating cAMP and intracellular calcium levels. We also measured the expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-1β. AEDK decreased gene expression and the secretion of the pro-inflammatory cytokines, TNF-α and IL-1β by inhibiting nuclear factor-κB. In addition, AEDK inhibited systemic and cutaneous allergic reaction. The inhibitory effects of AEDK on allergic reaction and the release of histamine were found to be similar to those of disodium cromoglycate, a known anti-allergic drug. To isolate the active component of AEDK, activity-guided fractionation was performed, based on the inhibitory effects on systemic anaphylaxis. Catechin was identified as an active compound. The present findings provide evidence that AEDK inhibits allergic inflammation and suggest the therapeutic application of AEDK in allergic inflammatory disorders.
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- 2013
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12. Vigna angularis inhibits mast cell-mediated allergic inflammation.
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Kim HH, Kim SW, Kim DS, Oh HM, Rho MC, and Kim SH
- Subjects
- Anaphylaxis drug therapy, Anaphylaxis immunology, Anaphylaxis metabolism, Animals, Anti-Allergic Agents administration & dosage, Calcium metabolism, Cell Line, Cytokines biosynthesis, Disease Models, Animal, Dose-Response Relationship, Drug, Histamine Release drug effects, Histamine Release immunology, Humans, Hypersensitivity drug therapy, Hypersensitivity metabolism, Inflammation Mediators metabolism, Male, Mast Cells metabolism, Mice, Mitogen-Activated Protein Kinases metabolism, NF-kappa B metabolism, Plant Extracts administration & dosage, Plant Extracts genetics, Signal Transduction drug effects, Anti-Allergic Agents pharmacology, Fabaceae chemistry, Hypersensitivity immunology, Mast Cells drug effects, Mast Cells immunology, Plant Extracts pharmacology
- Abstract
The aim of the present study was to elucidate whether extracts of Vigna angularis (EVA) inhibit allergic inflammatory reactions and to elucidate the possible mechanisms of action. For the assessment of allergic inflammatory response, histamine release and the expression of pro-inflammatory cytokines from human mast cells (HMC-1) were examined. To identify the underlying mechanisms of action, intracellular calcium and the activation of nuclear factor (NF)-κB and mitogen-activated protein kinases (MAPKs) were assayed. To confirm the effects of EVA in vivo, systemic and local allergic reaction mouse models were employed. EVA dose-dependently reduced phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI)-induced histamine release from mast cells. The inhibitory effects of EVA on the release of histamine from mast cells were mediated by the reduction of intracellular calcium levels. EVA decreased the PMACI-stimulated gene expression and secretion of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6. The inhibitory effects of EVA on pro-inflammatory cytokines were NF-κB- and MAPK-dependent. In addition, EVA inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E (IgE)-mediated cutaneous anaphylaxis. Our findings provide evidence that EVA inhibits mast cell-derived allergic inflammation, and suggest the possible therapeutic application of EVA in allergic inflammatory disorders.
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- 2013
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13. Piceatannol inhibits mast cell-mediated allergic inflammation.
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Ko YJ, Kim HH, Kim EJ, Katakura Y, Lee WS, Kim GS, and Ryu CH
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- Anaphylaxis chemically induced, Animals, Anti-Inflammatory Agents chemistry, Cell Line, Cell Survival drug effects, Cytokines analysis, Cytokines genetics, Cytokines metabolism, Extracellular Signal-Regulated MAP Kinases metabolism, Histamine metabolism, Humans, Male, Mice, Mice, Inbred ICR, Stilbenes chemistry, beta-N-Acetylhexosaminidases metabolism, p-Methoxy-N-methylphenethylamine toxicity, Anti-Inflammatory Agents pharmacology, Mast Cells drug effects, Mast Cells metabolism, Signal Transduction drug effects, Stilbenes pharmacology
- Abstract
Piceatannol is a phenolic stilbenoid and a metabolite of resveratrol which is found in red wine. Piceatannol (PIC) commonly exhibits anti-inflammatory, antiplatelet and antiproliferative activity. In the present study, the anti-allergic and anti-inflammatory mechanisms of PIC were investigated by examining the effects of PIC on pro‑inflammatory cytokine release and phosphorylation of mitogen-activated protein (MAP) kinases (ERK, JNK and p38) in a human mast cell line. PIC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E-mediated local allergic reactions. PIC reduced the immunoglobulin E (IgE)-mediated local allergic reaction and attenuated histamine release from rat peritoneal mast cells. Histamine and β-hexosaminidase release was markedly decreased dose-dependently by PIC treatment in RBL-2H3 cells. PIC treatments of HMC-1 cells definitely reduced mRNA expression and the release of the pro‑inflammatory cytokines, tumor necrosis factor-α and interleukin-8. MAP kinase phosphorylation was also strongly decreased dose-dependently following PIC treatment. PIC regulated the production of cytokines and histamine in phorbol 12-myristate 13-acetate plus A23187-stimulated mast cells. Thus, PIC may alleviate allergic inflammation and may be a useful therapeutic agent for allergic diseases.
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- 2013
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14. Sparassis crispa suppresses mast cell-mediated allergic inflammation: Role of calcium, mitogen-activated protein kinase and nuclear factor-κB.
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Kim HH, Lee S, Singh TS, Choi JK, Shin TY, and Kim SH
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- Anaphylaxis chemically induced, Anaphylaxis drug therapy, Animals, Complex Mixtures administration & dosage, Complex Mixtures pharmacology, Cytokines metabolism, Enzyme Activation drug effects, Histamine Release drug effects, Hypersensitivity drug therapy, Hypersensitivity immunology, Inflammation Mediators metabolism, Male, Mast Cells immunology, Mice, Mice, Inbred ICR, Rats, Rats, Sprague-Dawley, p-Methoxy-N-methylphenethylamine adverse effects, Calcium metabolism, Hypersensitivity metabolism, Mast Cells drug effects, Mast Cells metabolism, Mitogen-Activated Protein Kinases metabolism, NF-kappa B metabolism, Polyporales chemistry
- Abstract
Allergic inflammatory disease such as food allergy, asthma and atopic dermatitis are increasing worldwide. In this study, we investigated the effect of water extract of Sparassis crispa (WESC) Fr. (Aphyllophoromycetideae) on mast cell-mediated allergic inflammation and the possible mechanisms of action. WESC inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. WESC decreased immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis. Additionally, WESC reduced histamine release and intracellular calcium in human mast cells activated by phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. WESC decreased PMA and A23187-stimulated expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-α, inlerleukin (IL)-6 and IL-1β. The inhibitory effect of WESC on pro-inflammatory cytokines was nuclear factor-κB, extracellular signal-regulated kinase and p38 mitogen-activated protein kinase-dependent. Our results suggest potential therapeutic application of WESC in allergic inflammatory diseases.
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- 2012
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15. Ripe fruit of Rubus coreanus inhibits mast cell-mediated allergic inflammation.
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Kim HH, Choi PH, Yoo JS, Jeon H, Chae BS, Park JS, Kim SH, and Shin TY
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- Anaphylaxis chemically induced, Animals, Calcium metabolism, Caspase 1 metabolism, Cell Line, Disease Models, Animal, Enzyme Activation drug effects, Gene Expression drug effects, Histamine Release drug effects, Humans, Inflammation immunology, Inflammation Mediators metabolism, Male, Mice, Mitogen-Activated Protein Kinases metabolism, NF-kappa B metabolism, Rats, Rats, Sprague-Dawley, p-Methoxy-N-methylphenethylamine adverse effects, Anaphylaxis immunology, Fruit chemistry, Mast Cells drug effects, Mast Cells immunology, Plant Extracts pharmacology, Rosaceae chemistry
- Abstract
In this study, we investigated the effect of a water extract of the ripe fruits of Rubus coreanus Miq. (Rosaceae) (RFRC) on mast cell-mediated allergic inflammation and studied the possible mechanism of action. Mast cell-mediated allergic disease is involved in many diseases such as anaphylaxis, rhinitis, asthma and atopic dermatitis. RFRC dose-dependently inhibited compound 48/80-induced systemic anaphylaxis and serum histamine release in mice. RFRC reduced the immunoglobulin E (IgE)-mediated local allergic reaction, passive cutaneous anaphylaxis. RFRC attenuated histamine release from rat peritoneal mast cells and human mast cells by the reduction of intracellular calcium. RFRC decreased the phorbol 12-myristate 13-acetate (PMA) and the calcium ionophore A23187 (PMACI)-stimulated expression and secretion of pro-inflammatory cytokines in human mast cells. The inhibitory effect of RFRC on cytokine production was nuclear factor (NF)-κB- and mitogen-activated protein kinase (MAPK)-dependent. In addition, RFRC suppressed the activation of caspase-1. Our findings provide evidence that RFRC inhibits mast cell-derived allergic inflammatory reactions, and for the involvement of calcium, NF-κB, MAPKs and caspase-1 in these effects. Furthermore, in vivo and in vitro anti-allergic inflammatory effects of RFRC provide affirmative proof of a possible therapeutic application of this agent in allergic inflammatory diseases.
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- 2012
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16. Elsholtzia ciliata inhibits mast cell-mediated allergic inflammation: role of calcium, p38 mitogen-activated protein kinase and nuclear factor-{kappa}B.
- Author
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Kim HH, Yoo JS, Lee HS, Kwon TK, Shin TY, and Kim SH
- Subjects
- Animals, Calcium blood, Histamine Release drug effects, Hypersensitivity physiopathology, Inflammation drug therapy, Inflammation physiopathology, Male, Mast Cells physiology, Mice, Mice, Inbred ICR, NF-kappa B drug effects, Passive Cutaneous Anaphylaxis drug effects, Rats, Rats, Sprague-Dawley, p-Methoxy-N-methylphenethylamine pharmacology, p38 Mitogen-Activated Protein Kinases drug effects, Calcium physiology, Hypersensitivity drug therapy, Lamiaceae, Mast Cells drug effects, NF-kappa B physiology, Plant Extracts pharmacology, p38 Mitogen-Activated Protein Kinases physiology
- Abstract
Mast cell-mediated allergic reaction is involved in many diseases such as asthma and allergic rhinitis. Therefore, discovery of drugs for the prevention or treatment of allergic disease is an important topic in human health. In this study, we evaluated the effects of water extract of Elsholtzia ciliata (Thunb.) Hyland (Labiatae) (WEEC) on mast cell-mediated allergic inflammation and studied the possible mechanisms of action. WEEC inhibited compound 48/80-induced systemic and immunoglobulin E-mediated local anaphylaxis, and serum histamine release in mice. WEEC reduced intracellular calcium levels and downstream histamine release from human mast cells (HMC-1) activated with phorbol 12-myristate 13-acetate and calcium ionophore A23187. In addition, WEEC decreased gene expression and secretion of proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1β and IL-6 in HMC-1. The inhibitory effect of WEEC on cytokine expression was nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) dependent. Our results indicate that WEEC inhibits mast cell-mediated allergic inflammatory reactions by suppressing histamine release and proinflammatory cytokine expression, and involvement of calcium, NF-κB and p38 MAPK in these effects.
- Published
- 2011
- Full Text
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17. Suppression of mast-cell-mediated allergic inflammation by Lindera obtusiloba.
- Author
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Suh WM, Park SB, Lee S, Kim HH, Suk K, Son JH, Kwon TK, Choi HG, Lee SH, and Kim SH
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- Animals, Anti-Allergic Agents isolation & purification, Anti-Allergic Agents pharmacology, Calcium metabolism, Cell Line, Disease Models, Animal, Gene Expression, Histamine metabolism, Humans, Interleukin-6 antagonists & inhibitors, Interleukin-6 biosynthesis, Mice, Plant Extracts isolation & purification, Plant Extracts pharmacology, Signal Transduction, Tumor Necrosis Factor-alpha antagonists & inhibitors, Tumor Necrosis Factor-alpha biosynthesis, Anti-Allergic Agents administration & dosage, Hypersensitivity drug therapy, Inflammation prevention & control, Lindera chemistry, Mast Cells drug effects, Mast Cells immunology, Plant Extracts administration & dosage
- Abstract
Allergic disease is a consequence of exposure to normally innocuous substances that elicit the activation of mast cells. Mast-cell-mediated allergic response is involved in many diseases such as anaphylaxis, allergic rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of Lindera obtusiloba water extract (LOWE) on the mast-cell-mediated allergic inflammation and possible mechanism of action using in vitro and in vivo models. LOWE reduced histamine release from various types of mast cells activated by immunoglobulin E (IgE) or phorbol 12-myristate 13-acetate and calcium ionophore A23187 (PMACI). The inhibitory effect of LOWE on histamine release was mediated by calcium signal. LOWE decreased the PMACI-stimulated gene expression of proinflammatory cytokines such as tumor necrosis factor-α and interleukin-6 in human mast cells. The inhibitory effect of LOWE on the proinflammatory cytokines was nuclear factor (NF)-κB dependent. In addition, LOWE suppressed compound 48/80-induced systemic allergic reaction and serum histamine release in mice and IgE-mediated local allergic reactions. Our results indicate that LOWE inhibits mast-cell-derived allergic inflammation and involvement of calcium, histamine, proinflammatory cytokines and NF-κB in these effects.
- Published
- 2011
- Full Text
- View/download PDF
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