32 results on '"Aneiros-Cachaza J"'
Search Results
2. Assessment of incompletely excised Basal cell carcinomas in six facial areas: influence of elastosis.
- Author
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Husein-Elahmed, H, Aneiros-Fernandez, J, Gutierrez-Salmeron, M T, Aneiros-Cachaza, J, and Naranjo-Sintes, R
- Published
- 2012
3. Ulceration of the scalp: lipogranuloma induced by industrial oils in an interior decorator.
- Author
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Husein-ElAhmed, H., Hernandez-Soriano, M. I., Aneiros-Cachaza, J., Ruiz-Carrascosa, J. C., and Naranjo-Sintes, R.
- Published
- 2011
4. A pregnant woman with a nodule on the tongue: a quiz. Lobular capillary haemangioma (pyogenic granuloma)
- Author
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Arias-Santiago, Salvador, Aneiros-Fernandez, José, Orgaz-Molina, Jacinto, Fernández-Pugnaire, María Antonia, Girón-Prieto, Maria Sierra, Naranjo-Sintes, Ramón, Aneiros-Cachaza, Jose, Arias-Santiago, S, Orgaz-Molina,J, Aneiros-Fernandez, J, Fernandez-Pugnaire,MA, Giron-Prieto, MS, Naranjo-Sintes, R, ] Department of Dermatology, San Cecilio University Hospital, Granada, Spain. [Aneiros-Fernandez, J, and Aneiros-Cachaza, J] Department of Pathology, San Cecilio University Hospital, Granada, Spain
- Subjects
Complicaciones del Embarazo ,Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications [Medical Subject Headings] ,Adulto ,Embarazo ,Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Granuloma::Granuloma, Pyogenic [Medical Subject Headings] ,Femenino ,Humanos ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunohistochemistry [Medical Subject Headings] ,body regions ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,Biopsia ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Biopsy [Medical Subject Headings] ,Check Tags::Female [Medical Subject Headings] ,Granuloma Piogénico ,Named Groups::Persons::Age Groups::Adult [Medical Subject Headings] ,Enfermedades de la Lengua ,Diseases::Stomatognathic Diseases::Mouth Diseases::Tongue Diseases [Medical Subject Headings] ,Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy [Medical Subject Headings] ,Inmunohistoquímica - Abstract
Diagnosis: Lobular capillary haemangioma (pyogenic granuloma) A 34-year-old woman, in her fourth month of pregnancy, presented with an isolated exophytic lesion of the tongue, which had developed 2 months previously and which caused discomfort when swallowing. Yes
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- 2011
5. Smoothelin and WT-1 expression in glomus tumors and glomuvenous malformations.
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Aneiros-Fernandez J, Retamero JA, Husein-ElAhmed H, Carriel V, Ruiz Villaverde R, O'Valle F, and Aneiros-Cachaza J
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- Actins metabolism, Adolescent, Adult, Aged, Child, Desmin metabolism, Female, Glomus Tumor pathology, Humans, Immunohistochemistry, Infant, Male, Middle Aged, Myocytes, Smooth Muscle metabolism, Myocytes, Smooth Muscle pathology, Myosins metabolism, Paraganglioma, Extra-Adrenal pathology, Soft Tissue Neoplasms pathology, Arm pathology, Cytoskeletal Proteins metabolism, Glomus Tumor metabolism, Muscle Proteins metabolism, Paraganglioma, Extra-Adrenal metabolism, Soft Tissue Neoplasms metabolism, Thigh pathology, WT1 Proteins metabolism
- Abstract
Background: Smoothelin is a specific marker for smooth muscle cells with contractile capacity which has not been widely studied in glomus lesions. In the same way, the expression for Wilms tumor 1 (WT1) has only been studied occasionally in the endothelial cells of glomovenous malformations and in the glomus cells of glomus tumours., Objective: We studied the significance of immunohistochemical expression of smoothelin and WT1 in 25 glomus lesions., Methods: We assessed 9 cases of solid glomus tumors (SGT), 8 cases of glomus tumors with vascular ectasia (VEGT), 2 cases of glomangiomyomas (GMM) and 6 cases of glomuvenous malformation (GM). Immunohistochemistry was performed, evaluating the expression of WT1, smoothelin, smooth muscle actin (SMA), smooth muscle myosin (SMM), h-caldesmon and desmin., Results: Glomic cells showed cytoplasmic positivity for smoothelin, and WT1 expression was present in all studied cases. SGT showed WT1 positivity in all endothelia. However, in regarding VEGT and GMM, WT1 endothelial expression was positive in some areas, but not in others. GM did not show endothelial cell positivity for WT1., Conclusions: Smoothelin expression in glomic cells indicates that they are contractile smooth muscle cells, and thus its role in routine diagnosis should be considered. The absence of WT1 expression in the endothelium of the vascular structures of the GM is a differential characteristic between SGT, VEGT and GMM.
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- 2017
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6. Basal cell carcinoma arising in outdoor workers versus indoor workers: a retrospective study.
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Husein-Elahmed H, Gutierrez-Salmeron MT, Aneiros-Cachaza J, and Naranjo-Sintes R
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- Aged, Aged, 80 and over, Carcinoma, Basal Cell etiology, Carcinoma, Basal Cell pathology, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Skin Neoplasms etiology, Skin Neoplasms pathology, Carcinoma, Basal Cell epidemiology, Occupational Exposure adverse effects, Skin Neoplasms epidemiology, Ultraviolet Rays adverse effects
- Abstract
Basal cell carcinoma (BCC) is the most prevalent malignancy in white individuals and continues to be a serious health problem. Individuals who have sustained exposure to UV radiation are at the highest risk for developing BCC. The aim of this study was to compare the features of BCC in outdoor workers (OWs) with a history of occupational exposure to UV radiation versus indoor workers (IWs). We found that OWs are more likely to develop nodular BCC with no increased risk for superficial BCC. The age of onset of BCC was older in OWs than in IWs. Truncal BCC was more common in IWs, which may suggest other etiological factors are involved in BCC such as genetic predisposition.
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- 2017
7. Primary cutaneous and subcutaneous leiomyosarcomas: evolution and prognostic factors.
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Aneiros-Fernandez J, Antonio Retamero J, Husein-Elahmed H, Ovalle F, and Aneiros-Cachaza J
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- Humans, Leiomyosarcoma mortality, Neoplasm Metastasis, Neoplasm Recurrence, Local mortality, Prognosis, Skin Neoplasms mortality, Soft Tissue Neoplasms mortality, Leiomyosarcoma pathology, Neoplasm Recurrence, Local pathology, Skin Neoplasms pathology, Soft Tissue Neoplasms pathology
- Abstract
Cutaneous and subcutaneous leiomyosarcomas (LMS) are uncommon neoplasms. We reviewed the MEDLINE database to assess their rates of recurrence and metastasis, mortality and recommended follow-up period. Other prognostic factors were also studied. This review included 112 subcutaneous LMS and 313 cutaneous LMS. In subcutaneous LMS, we observed that rates of recurrence, metastasis and mortality were 36.63%, 43.23% and 37.82%, respectively, after a median follow-up period of 4.40 years, while in cutaneous LMS those figures were 24.40%, 4.22% and 3.33%, respectively, after a median follow-up period of 3.45 years. Although subcutaneous and cutaneous LMS show similar morphologic features, the latter show less tendency to recur and metastasize; in certain cases they both may be the cause of death. For these reasons we suggest avoiding the term "atypical intradermal smooth muscle neoplasm". Location, size and histologic grade are essential prognostic factors for superficial LMS. Recurrence after incomplete excision can be avoided when performed with a surgical margin of at least 1 cm. Follow-up should be at least five years.
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- 2016
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8. Basal cell carcinoma: analysis of factors associated with incomplete excision at a referral hospital in southern Spain.
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Husein-Elahmed H, Aneiros-Fernandez J, Gutierrez-Salmeron MT, Aneiros-Cachaza J, and Naranjo-Sintes R
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- Adult, Aged, Aged, 80 and over, Carcinoma, Basal Cell surgery, Cohort Studies, Female, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm, Residual, Neoplasms, Multiple Primary surgery, Retrospective Studies, Risk Factors, Skin Neoplasms surgery, Spain, Tumor Burden, Carcinoma, Basal Cell pathology, Neoplasms, Multiple Primary pathology, Skin Neoplasms pathology
- Abstract
Basal cell carcinoma (BCC) is the most prevalent malignancy, with excision as the best therapeutic approach. Incomplete excision of nonmelanoma skin cancer is a clinical indicator of the surgical technique performed. This retrospective study of 292 patients with BCC assessed the rate of incomplete excision in a tertiary referral hospital in southern Spain and its relationship with tumor location as well as histologic and surgical features.
- Published
- 2014
9. Solitary eccrine syringofibroadenoma arising on the toe.
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Husein-ElAhmed H, Caba-Molina M, Naranjo-Sintes R, and Aneiros-Cachaza J
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- Adenoma, Sweat Gland classification, Adenoma, Sweat Gland surgery, Aged, Diagnosis, Differential, Eccrine Glands surgery, Humans, Male, Toes pathology, Toes surgery, Treatment Outcome, Adenoma, Sweat Gland pathology, Eccrine Glands pathology, Foot Diseases pathology, Foot Diseases surgery, Sweat Gland Neoplasms pathology, Sweat Gland Neoplasms surgery
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- 2014
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10. MT1 melatonin receptor expression in Warthin's tumor.
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Aneiros-Fernandez J, Arias-Santiago S, Arias-Santiago B, Herrero-Fernández M, Carriel V, Aneiros-Cachaza J, López-Valverde A, and Cutando-Soriano A
- Subjects
- Adenolymphoma genetics, Adenolymphoma pathology, Adult, Epithelial Cells metabolism, Epithelial Cells pathology, Female, Humans, Immunohistochemistry, Male, Middle Aged, Parotid Gland metabolism, Parotid Gland pathology, Receptor, Melatonin, MT1 genetics, Receptor, Melatonin, MT1 metabolism, Adenolymphoma metabolism, Receptor, Melatonin, MT1 biosynthesis
- Abstract
We contribute the first immunohistochemical study of MT1 melatonin receptor in Warthin's tumor and normal parotid gland. All 14 Warthin's tumors studied showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in basal cells. The lymphoid component accompanying the tumor was always negative for MT1 receptor. The parotid structure surrounding the tumor showed intense cytoplasmic positivity in all cells lining excretory ducts (lobar and lobulillar), with a lesser and focal positivity in cells of the acinar component. The biological activity of MT1 receptor in epithelial cells lining parotid excretory ducts may resemble its activity in Warthin's tumor cells. Hence, we propose Warthin's tumor as a useful positive control in immunohistochemical studies of MT1 melatonin receptor.
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- 2013
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11. Factors related to delay in the diagnosis of basal cell carcinoma.
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Husein-Elahmed H, Gutierrez-Salmeron MT, Naranjo-Sintes R, and Aneiros-Cachaza J
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- Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Carcinoma, Basal Cell diagnosis, Delayed Diagnosis statistics & numerical data, Skin Neoplasms diagnosis
- Abstract
Background: There is often a delay between the clinical emergence of a basal cell carcinoma (BCC) and the point in time at which the patient presents for definitive diagnosis and treatment. Previously published studies on delays regarding skin cancer have focused on melanoma rather than BCC. We conducted a study aimed at identifying factors associated with the detection of BCC and reasons for the delay in diagnosis., Method: A monocentric study was performed. Patients with a primary BCC diagnosed in 2010 were included in the study. They were asked about factors concerning BCC awareness and detection, tumor characteristics, previous history of nonmelanoma cutaneous cancer, family history of nonmelanoma cutaneous cancer, and the presence of comorbidities. Data were analyzed using SPSS software., Results: The mean diagnostic delay for BCC in our hospital setting was estimated at 19.79 ± 14.71 months. Delayed diagnosis was significantly associated with patients over 65 years, those without a previous history of BCC, those without a family history of BCC, those with BCC located elsewhere than the head or neck, and those with lesions not associated with itching or bleeding., Conclusion: This study revealed considerable delay in the diagnosis of BCC. The main reason for delay in the diagnosis seems to be the initial decision of the patient to seek medical advice. These data suggest a need for greater information for the general public on the symptoms and signs that should prompt suspicion of a BCC.
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- 2013
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12. MTNR1A receptor expression in normal and pathological human salivary glands.
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Arias-Santiago S, Aneiros-Fernández J, Arias-Santiago B, Girón-Prieto MS, Caba-Molina M, López-Valverde A, Aneiros-Cachaza J, Campos A, and Cutando A
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- Adenolymphoma pathology, Adult, Aged, Humans, Immunohistochemistry, Middle Aged, RNA, Messenger analysis, Receptor, Melatonin, MT1 analysis, Salivary Gland Neoplasms pathology, Salivary Glands pathology, Adenolymphoma metabolism, Biomarkers, Tumor analysis, Receptor, Melatonin, MT1 biosynthesis, Salivary Gland Neoplasms metabolism, Salivary Glands metabolism
- Abstract
Aim: To analyze and compare the expression of MTNR1A receptor in normal and pathological major and minor salivary glands., Materials and Methods: Twenty samples of major and minor salivary glands and 10 with Warthin's tumor were studied. Expression of the MTNR1A receptor (goat polyclonal antibody raised against a peptide mapping at the N-terminus of MEL-1A R of human origin) was analyzed., Results: The excretory ducts of major salivary glands demonstrated intense intracytoplasmic positivity but scant cytoplasmic membrane positivity for MTNR1A. The studied Warthin's tumors showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in basal cells. The lymphoid component accompanying the tumor was negative for MT1 receptor., Conclusion: Intense intracytoplasmic positivity for the MTNR1A receptor in the excretory ducts of human major and minor salivary glands and Warthin's tumor was found. The intense expression of MTNR1A receptors observed in this study in the excretory ducts of major and minor salivary glands may be related to salivary regulation.
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- 2012
13. Alcohol intake and risk of aggressive histological basal cell carcinoma: a case-control study.
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Husein-Elahmed H, Aneiros-Fernandez J, Gutierrez-Salmerón MT, Botella-Lopez M, Aneiros-Cachaza J, and Naranjo-Sintes R
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- Aged, Case-Control Studies, Female, Humans, Male, Prospective Studies, Risk Factors, Severity of Illness Index, Surveys and Questionnaires, Alcohol Drinking adverse effects, Carcinoma, Basal Cell epidemiology, Carcinoma, Basal Cell pathology, Skin Neoplasms epidemiology, Skin Neoplasms pathology
- Abstract
Background: Aggressive basal cell carcinomas (BCC) are not rare. These subtypes of skin cancer are characterized by an infiltrative behavior and rapid progression. Often, management may be difficult. Recent evidence suggests that minimal UV exposure in combination with other behavioral and/or environmental factors may lead to higher incidence of BCC and, therefore, more risk of aggressive subtypes of this malignancy. Alcohol is a very commonly consumed beverage in Western societies, especially in association with outdoors activities., Objective: To investigate a possible relationship between alcohol intake and aggressive histological variants of BCC., Materials and Method: We designed a prospective study. Patients who underwent surgery for BCC in our hospital were interviewed to collect data regarding alcohol intake. The specimens were reviewed by a pathologist and classified into aggressive and non-aggressive subtypes. Statistical analysis was performed using SPSS software., Results: 136 patients were included. Of participants with aggressive BCCs, 10 (26.3%) were abstainers, 4 (10.4%) had light consumption, 18 (47.5%) moderate consumption and 6 (15.8%) heavy consumption, while among participants with non-aggressive BCCs, 57 (58.2%) were abstainers, 29 (29.5%) had light consumption, 10 (10.2%) moderate consumption and 2 (2.1%) heavy consumption. In the multivariate analysis we found a positive significant association between alcohol consumption and the presence of aggressive BBCs., Conclusions: According to our results, alcohol intake may be linked with a higher incidence of aggressive subtypes of BCC.
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- 2012
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14. "Eruptive" facial syringomas: an inflammatory skin reaction?
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Husein-ElAhmed H, Aneiros-Fernandez J, and Aneiros-Cachaza J
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- Adult, Diagnosis, Differential, Face, Female, Humans, Inflammation pathology, Skin pathology, Sweat Gland Neoplasms pathology, Syringoma pathology, Inflammation diagnosis, Sweat Gland Neoplasms diagnosis, Syringoma diagnosis
- Abstract
A 26-year-old woman exhibited multiple, 1- to 3-mm eruptive asymptomatic papules, symmetrically distributed on the face. None of her family members had similar lesions. The papules first appeared in 2006 and gradually increased in number, particularly during her first pregnancy. She stated that the development of lesions was preceded by dermatitis. Physical examination revealed many flesh-colored or slightly reddish, smooth-surfaced papules around the eyes, both cheeks, and temples (Figure 1 and Figure 2). The differential diagnosis included syringomas in an atypical location, cutaneous sarcoidosis, and periorificial dermatitis. Histopathologic examinations revealed aggregation of small tubular structures lined by two rows of epithelial cells, most of which were characterized by comma-like tails, giving them a tadpole shape. They were embedded in a fibrous connective tissue stroma in the dermis. These histopathologic findings were consistent with syringoma (Figure 3).
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- 2012
15. Ulceration of the scalp: lipogranuloma induced by industrial oils in a decorator woman.
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Husein-Elahmed H, Soriano-Hernandez MI, Aneiros-Cachaza J, Ruiz-Carrascosa JC, and Naranjo-Sintes R
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- Female, Granuloma, Foreign-Body pathology, Humans, Middle Aged, Scalp Dermatoses pathology, Granuloma, Foreign-Body chemically induced, Industrial Oils adverse effects, Scalp pathology, Scalp Dermatoses chemically induced
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- 2012
16. Effect of non-steroidal anti-inflammatory drugs on the histology of basal cell carcinomas.
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Husein-El Ahmed H, Aneiros-Fernandez J, Gutierrez-Salmeron MT, Aneiros-Cachaza J, and Naranjo-Sintes R
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- Aged, Case-Control Studies, Confidence Intervals, Female, Humans, Logistic Models, Male, Odds Ratio, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Carcinoma, Basal Cell pathology, Skin Neoplasms pathology
- Abstract
Background: Aggressive histology is not rare in BCC. Large studies from referral centers report incidences of aggressive histology BCC ranging from 2.5- 44%. These aggressive BCC are characterized by subclinical extension, invasive behavior, local recurrence and challenging treatment., Objectives: To examine the association between non-steroidal anti-inflammatory drug (NSAID) use and the different histological subtypes of basal cell carcinoma (BCC)., Methods: The design was a nested case-control study. The two population-based cohorts were of patients with a primary BCC diagnosis during January and May 2010 (n=136) and NSAID use in the 15 years prior to baseline. All the lesions were excised and analyzed to determinate the histological subtype of BCC as aggressive or non-aggressive. Odds ratios (ORs) and 95% confidence intervals (CIs), using conditional logistic regression, were calculated with the SPSS software to estimate the association of aggressive histological subtypes of BCC and use of NSAID. We controlled the potential confounding factors., Results: The rate of non-aggressive BCC associated with exposure to NSAID was increased (OD: 0.34; 95% CI: 0.14-0.84) after adjusting for covariants., Limitations: our sample is small. We collected data regarding use of NSAID over a wide time ranges, so that we are unable to propose when the potential benefits of NSAID on the histology of BCC would happen., Conclusion: According to our data, NSAID exposure is associated with a decreased risk of aggressive BCC.
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- 2012
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17. A new perspective in Oral health: potential importance and actions of melatonin receptors MT1, MT2, MT3, and RZR/ROR in the oral cavity.
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Cutando A, Aneiros-Fernández J, López-Valverde A, Arias-Santiago S, Aneiros-Cachaza J, and Reiter RJ
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- Humans, Mouth physiology, Mouth Diseases prevention & control, Nuclear Receptor Subfamily 1, Group F, Member 1 physiology, Receptor, Melatonin, MT1 physiology, Receptor, Melatonin, MT2 physiology, Melatonin physiology, Oral Health, Receptors, Melatonin physiology
- Abstract
Background: Melatonin is involved in many physiological processes in mammals, amongst others; it is implicated in sleep-wake regulation. It has antioxidant and anti-inflammatory properties. It also acts as an immunomodulator, stimulates bone metabolism and inhibits various tumours. Additionally an abnormal melatonin rhythm may contribute to depression and insomnia. The mechanisms of action of melatonin include the involvement of membrane receptors (MT1, MT2), cytosolic binding sites (MT3 and calmodulin), and nuclear receptors of the RZR/ROR family. Melatonin also has receptor-independent activity and can directly scavenge free radicals. The current review addresses the functions of melatonin in the oral cavity in relation to its receptors., Methods: An extensive search was conducted on the following scientific databases Pub Med, Science Direct, ISI Web of Knowledge and Cochrane database in order to review all pertinent literature., Results: Melatonin from the blood into the saliva may play an important role in suppressing oral diseases. It may have beneficial effects in periodontal disease, herpes and oral cancer, amongst others., Conclusions: Melatonin contributes to protecting of oral cavity from tissue damage due to its action of different receptors. From the reviewed literature it is concluded that experimental evidence suggests that melatonin can be useful in treating several common diseases of the oral cavity. Specific studies are necessary to extend the therapeutic possibilities of melatonin to other oral diseases., (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Published
- 2011
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18. A pregnant woman with a nodule on the tongue: a quiz. Lobular capillary haemangioma (pyogenic granuloma).
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Arias-Santiago S, Aneiros-Fernandez J, Orgaz-Molina J, Fernández-Pugnaire MA, Girón-Prieto MS, Naranjo-Sintes R, and Aneiros-Cachaza J
- Subjects
- Adult, Biopsy, Female, Granuloma, Pyogenic pathology, Granuloma, Pyogenic surgery, Humans, Immunohistochemistry, Pregnancy, Pregnancy Complications pathology, Pregnancy Complications surgery, Tongue Diseases pathology, Tongue Diseases surgery, Granuloma, Pyogenic diagnosis, Pregnancy Complications diagnosis, Tongue Diseases diagnosis
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- 2011
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19. Melatonin and cancer: current knowledge and its application to oral cavity tumours.
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Cutando A, Aneiros-Fernández J, Aneiros-Cachaza J, and Arias-Santiago S
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- Antioxidants therapeutic use, Humans, Melatonin therapeutic use, Carcinoma prevention & control, Melatonin physiology, Mouth Neoplasms prevention & control, Receptors, Melatonin physiology
- Abstract
Background: Melatonin (MLT) is a molecule secreted by the pineal gland in cyclical periods. In mammals, MLT is involved in physiological processes, such as sleep/wake regulation in the circadian cycle. It has antioxidant and anti-inflammatory properties, functions as an immunomodulator, and stimulates bone metabolism. MLT is also involved in tumour processes in breast, prostate, liver, and bone cancers, among others, and in oral cavity tumours like epidermoid carcinoma. We are gradually increasing our knowledge of the underlying mechanism of MLT action in the aforementioned tumour processes, in which MT1, MT2, MT3, and RZR receptors appear to play a highly important role. These receptors belong to a large family of G-protein-coupled transmembrane receptors, some of which have been linked to melatonin's anticancer action, to tumour growth, and to prognosis. The objective of this article is to provide a clear review of research into the range of MLT functions, focusing specifically on MT receptors. We aim to contribute interesting, new approaches to research into oral cavity tumours., Methods: An extensive review of the research literature was conducted using PubMed, Science Direct, ISI Web of Knowledge, and the Cochrane base., Results: This study highlights the growing importance of MLT in the prognosis and treatment of certain tumours, including epidermoid carcinoma in the oral cavity. Moreover, it opens up a highly original, encouraging line of research in the field of tumours., Conclusions: MLT contributes to protecting the oral cavity from tissue damage caused by receptor action. Experimental evidence suggests that it may be useful in the treatment and prognosis of tumour processes in the oral cavity., (© 2011 John Wiley & Sons A/S.)
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- 2011
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20. Hemangiopericytoma-like dermatofibroma with mast cells.
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Aneiros-Fernandez J, Arias-Santiago S, Espiñeira-Carmona MJ, Caba-Molina M, Fernandez-Pugnaire MA, O'Valle F, del Moral RG, and Aneiros-Cachaza J
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- Aged, 80 and over, Angiomyoma diagnosis, Antigens, CD metabolism, Antigens, Differentiation, Myelomonocytic metabolism, Biomarkers, Tumor metabolism, Dermatofibrosarcoma diagnosis, Diagnosis, Differential, Factor XIIIa metabolism, Hemangiopericytoma metabolism, Hemangiopericytoma surgery, Histiocytoma, Benign Fibrous metabolism, Histiocytoma, Benign Fibrous surgery, Humans, Male, Mast Cells metabolism, Melanoma, Amelanotic diagnosis, Peripheral Nervous System Neoplasms diagnosis, Perivascular Epithelioid Cell Neoplasms diagnosis, Skin Neoplasms metabolism, Skin Neoplasms surgery, Solitary Fibrous Tumors diagnosis, Treatment Outcome, Hemangiopericytoma pathology, Histiocytoma, Benign Fibrous pathology, Mast Cells pathology, Skin Neoplasms pathology
- Abstract
We report an unusual case of hemangiopericytoma-like dermatofibroma in the right shoulder of an 82-year-old patient with a well-defined nodular growth located in the dermis. Microscopic study revealed a band of haphazardly arranged cells with a vascular component of gaping, simple, endothelial-lined vascular structures with intervening postcapillary venules and capillary-sized slit-like "staghorn" vascular channels filled with erythrocytes; abundant mast cells were also observed. The neoplasm cells were positive for CD68 and Factor XIIIA and negative for CD34. Few data have been published on the presence of abundant mast cells (tryptase and CD117 positive) in these neoplasm. The differential diagnosis of this entity should consider other spindle cell neoplasm, including hemangiopericytoma/solitary fibrous tumor, dermatofibrosarcoma protuberans, myopericytoma, angioleiomyoma, amelanotic melanoma, pecoma, and benign and malignant peripheral nerve tumors. We present an infrequent case of dermatofibroma with a vascular pattern resembling hemangiopericytoma and the presence of abundant mast cells, which may be responsible for this vascular component.
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- 2011
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21. Annular erythematous papules in the neckline.
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Espiñeira-Carmona MJ, Arias-Santiago S, Aneiros-Fernández J, Fernández-Pugnaire MA, Naranjo-Sintes R, and Aneiros-Cachaza J
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- Erythema drug therapy, Female, Granuloma, Giant Cell drug therapy, Humans, Immunosuppressive Agents therapeutic use, Middle Aged, Skin Diseases drug therapy, Tacrolimus therapeutic use, Erythema pathology, Granuloma, Giant Cell pathology, Skin Diseases pathology
- Abstract
A 45-year-old woman with personal history of hypertension presented with an erythematous lesion in the neckline for a year and with a progressive growth. A physical examination revealed an annular lesion with erythematous papules in the edge. Histological exam showed phagocytosis of elastic fibers by multinucleated cells compatible with annular elastolytic giant-cell granuloma. The patient did not present any other associated systemic manifestation. Treatment with tacrolimus 0.1 percent ointment was prescribed with a very good response after two months.
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- 2011
22. A 5-year-old boy with comedo-like lesions on the right buttock.
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Arias-Santiago S, Aneiros-Fernandez J, Buendía-Eisman A, Girón-Prieto MS, and Aneiros-Cachaza J
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- Child, Preschool, Diagnosis, Differential, Hair Follicle pathology, Humans, Male, Nevus diagnosis, Skin Neoplasms diagnosis, Buttocks pathology, Nevus pathology, Skin Neoplasms pathology
- Abstract
A healthy, 5-year-old boy presented with cutaneous lesions on the right buttock, evident at birth. A physical examination revealed plugged pores in a linear distribution with the appearance of comedones and scar areas. Histopathological exam revealed multiple atrophic cystically dilated hair follicles containing abundant keratinous debris and small projections of epithelial cells extending from the wall of the cyst into the surrounding dermis, compatible with nevus comedonicus.
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- 2010
23. Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall.
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Aneiros-Fernandez J, Arias-Santiago S, Husein-Elahmed H, Ovalle F, Siendones MI, and Aneiros-Cachaza J
- Abstract
Unlabelled: We report the clinical-morphological study of a granular cell tumor in dermal/hypodermal junction and subcutaneous fat left breast of an 83-year-old woman with a family history of breast carcinoma. Mammography study showed a spiculated lesion in the lower inner quadrant with suspicion of malignancy. The results of fine needle puncture-aspiration were inconclusive. Subsequent tumorectomy revealed a poorly-defined indurated lesion of 1.1 x 0.7 cm. The histopathology study showed a proliferation of cells with ample and granular cytoplasm that were positive for S100, CD 68 and inhibin and negative for hormonal receptors. We present a benign lesion that clinically reproduces a breast carcinoma., Keywords: Granular cell tumor; Breast; Differential diagnosis; Cutaneous.
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- 2010
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24. Acantholytic-like malignant melanoma: an unusual morphologic variant.
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Aneiros-Fernández J, Arias-Santiago S, Diaz-Recuero JL, O'valle Ravassa F, Nogales Fernández F, and Aneiros Cachaza J
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- Diagnosis, Differential, Humans, Male, Middle Aged, Acantholysis pathology, Melanoma pathology, Skin Neoplasms pathology
- Abstract
We report the case of a primary cutaneous melanoma with acantholytic-like changes in a 61-year-old man. Clinical and immunohistochemic features were similar to those of other superficial spreading with vertical growth melanomas. Histologically, intraepidermal and suprabasal bullous spaces were filled by isolated tumor cells, simulating acantholytic blisters. These findings could be explained by the presence of inflammation-related extracellular fluid. Two other cases with suprabasal discohesive atypical melanocytes have recently been described. We report the first case of malignant melanoma with an intense and diffuse pattern of dyscohesion, resembling acantholysis. Recognition of this histologic pattern in malignant melanoma is important to avoid a misdiagnosis.
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- 2010
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25. Myositis ossificans circumscripta without history of trauma.
- Author
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Aneiros-Fernandez J, Caba-Molina M, Arias-Santiago S, Ovalle F, Hernandez-Cortes P, and Aneiros-Cachaza J
- Abstract
Unlabelled: Myositis ossificans circumscripta is a form of heterotopic ossification that is benign in nature associated to a trauma, but may appear clinically and radiologically as a malignant neoplasm. We describe a rare case of calcifying of myositis ossificans not associated to trauma in a 35-year-old woman with a mass in her upper third and external of right thigh. We discuss some of the difficulties of diagnosis and histological evolution of the lesion., Keywords: Myositis ossificans; Thigh; Differential diagnosis; Nontraumatic.
- Published
- 2010
- Full Text
- View/download PDF
26. Lichenoid dermatosis induced by alendronate: an unusual skin drug reaction.
- Author
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Husein-Elahmed H, Aneiros-Fernandez J, Arias-Santiago S, Aneiros-Cachaza J, and Naranjo-Sintes R
- Subjects
- Aged, Biopsy, Glucocorticoids therapeutic use, Humans, Lichenoid Eruptions drug therapy, Lichenoid Eruptions pathology, Male, Osteoporosis complications, Prednisone therapeutic use, Skin pathology, Spinal Fractures etiology, Treatment Outcome, Alendronate adverse effects, Bone Density Conservation Agents adverse effects, Lichenoid Eruptions chemically induced, Lumbar Vertebrae injuries, Osteoporosis drug therapy, Skin drug effects, Spinal Fractures drug therapy
- Published
- 2010
- Full Text
- View/download PDF
27. Cutaneous metastasis as first clinical manifestation of signet ring cell gastric carcinoma.
- Author
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Aneiros-Fernandez J, Husein-ElAhmed H, Arias-Santiago S, Escobar Gómez-Villalva F, Nicolae A, O'Valle Ravassa F, and Aneiros-Cachaza J
- Subjects
- Aged, Antineoplastic Agents therapeutic use, Capecitabine, Carcinoma, Signet Ring Cell drug therapy, Carcinoma, Signet Ring Cell secondary, Deoxycytidine analogs & derivatives, Deoxycytidine therapeutic use, Docetaxel, Fluorouracil analogs & derivatives, Fluorouracil therapeutic use, Humans, Male, Skin Neoplasms drug therapy, Skin Neoplasms secondary, Stomach Neoplasms drug therapy, Stomach Neoplasms pathology, Taxoids therapeutic use, Carcinoma, Signet Ring Cell diagnosis, Skin Neoplasms diagnosis, Stomach Neoplasms diagnosis
- Abstract
Cutaneous metastases from signet ring cell gastric carcinoma are uncommon. A 69-year-old man presented with a 15-day history of an asymptomatic indurated scar-like lesion. The biopsy revealed an infiltrating signet ring cell carcinoma consistent with gastric metastasis. Gastroscopy and biopsy showed gastric carcinoma with signet ring cells; subsequent computed tomography revealed metastatic nodules in the liver, mesentery, and retroperitoneal and peripancreatic lymph nodes. A review of the 10 cases of cutaneous metastasis from signet ring cell carcinoma in the literature revealed that cutaneous metastases of gastric origin usually appear at earlier ages than in our patient and that the primary tumor is unknown at the time of skin biopsy in 64 percent of cases. The present report describes the unusual clinical-diagnostic sequence of a patient diagnosed with cutaneous metastasis before detection of his gastric carcinoma.
- Published
- 2010
28. Markers of metastasis in lip cancer.
- Author
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Fernández-Angel I, Rodríguez-Archilla A, Aneiros Cachaza J, Muñoz Medina M, and Serrano Ortega S
- Subjects
- Aged, Biomarkers, Tumor, Carcinoma, Squamous Cell etiology, Carcinoma, Squamous Cell secondary, Female, Humans, Incidence, Lip Neoplasms etiology, Lip Neoplasms pathology, Lymphatic Metastasis, Male, Medical Records, Middle Aged, Retrospective Studies, Risk Factors, Spain epidemiology, Carcinoma, Squamous Cell epidemiology, Lip Neoplasms epidemiology
- Abstract
The incidence of lip cancer in Granada, Spain, is much higher than that recorded in other countries. The natural history of the disease generally includes induction on previous actinic lesions, promotion with local growth of the tumour, and the appearance of metastasis in regional lymph node chains and, exceptionally, via the blood stream. In order to determine the risk factors for metastases, a retrospective hospital-based study was conducted of 251 cases of lower lip cancer diagnosed and treated during a 10-year period from 1985 to 1995. All patients studied had a minimum follow-up of five years. Among the metastasis risk factors considered, only localization in commissure showed statistical significance (p < 0.001).
- Published
- 2003
29. Mitotic activity in centrocytic and/or centroblastic lymphomas: analysis of 54 cases.
- Author
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Esquivias Lopez-Cuervo JJ, Garcia del Moral R, O'Valle Ravassa F, and Aneiros Cachaza J
- Subjects
- Humans, Lymphoma, AIDS-Related pathology, Lymphoma, Non-Hodgkin pathology, Mitosis
- Published
- 1992
- Full Text
- View/download PDF
30. Zinc deficiency dermatitis in parenteral nutrition: an electron-microscopic study.
- Author
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Serrano Ortega S, Aneiros Cachaza J, Tovar IV, and Feijoo MF
- Subjects
- Acute Disease, Dermatitis pathology, Humans, Microscopy, Electron, Skin ultrastructure, Dermatitis etiology, Parenteral Nutrition adverse effects, Zinc deficiency
- Abstract
Two cases of zinc deficiency dermatitis (acute phase) on parenteral nutrition are reported. Subepidermal blisters caused by a decrease in the number of desmosomes and hemidesmosomes located between the discontinuous basal membrane and cell membranes are shown. The collagen fibers presented changes which probably are responsible for the breaking or fragility of the capillaries. These facts went unnoticed in previous studies.
- Published
- 1985
- Full Text
- View/download PDF
31. Neuroendocrine changes in basal cell carcinoma.
- Author
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Aneiros-Cachaza J, Caracuel MD, Cámara M, and Alonso J
- Subjects
- Humans, Carcinoma, Basal Cell ultrastructure, Cytoplasmic Granules ultrastructure, Neurosecretory Systems ultrastructure, Skin Neoplasms ultrastructure
- Published
- 1988
32. Endocervical polyp with pseudosarcomatous pattern and cytoplasmic inclusions: an electron microscopic study.
- Author
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Aneiros Cachaza J, Lopez Caballero JJ, Alonso Fernandez J, and Salido E
- Subjects
- Adult, Cytoplasm ultrastructure, Female, Humans, Inclusion Bodies ultrastructure, Microscopy, Electron, Polyps ultrastructure, Uterine Cervical Neoplasms ultrastructure
- Abstract
A case of endocervical polyp with atypical stromal cells in a 32-year-old woman is reported. Light microscopy showed atypical stromal cells with eosinophilic cytoplasmic inclusions which, by electron microscopy, were nonmembrane-bound, compact fibrillary structures in close relationship with the cytoplasmic microfibrils. The ultrastructural features demonstrated a fibroblastic nature of bizarre cells. These inclusions are similar to those of infantile digital fibromatosis. These findings have not been reported previously.
- Published
- 1986
- Full Text
- View/download PDF
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