MTNR1A receptor expression in normal and pathological human salivary glands.

Authors :: Arias-Santiago S
Aneiros-Fernández J
Arias-Santiago B
Girón-Prieto MS
Caba-Molina M
López-Valverde A
Aneiros-Cachaza J
Campos A
Cutando A
Source :: Anticancer research [Anticancer Res] 2012 Nov; Vol. 32 (11), pp. 4765-71.
Publication Year :: 2012
Abstract: Aim: To analyze and compare the expression of MTNR1A receptor in normal and pathological major and minor salivary glands.<br />Materials and Methods: Twenty samples of major and minor salivary glands and 10 with Warthin's tumor were studied. Expression of the MTNR1A receptor (goat polyclonal antibody raised against a peptide mapping at the N-terminus of MEL-1A R of human origin) was analyzed.<br />Results: The excretory ducts of major salivary glands demonstrated intense intracytoplasmic positivity but scant cytoplasmic membrane positivity for MTNR1A. The studied Warthin's tumors showed intense cytoplasmic positivity for MT1 receptor in all cylindrical epithelial cells lining spaces and a less intense positivity in basal cells. The lymphoid component accompanying the tumor was negative for MT1 receptor.<br />Conclusion: Intense intracytoplasmic positivity for the MTNR1A receptor in the excretory ducts of human major and minor salivary glands and Warthin's tumor was found. The intense expression of MTNR1A receptors observed in this study in the excretory ducts of major and minor salivary glands may be related to salivary regulation.