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In the title compound, 2C14H19N4O3+·C7H3NO42−·5H2O, the asymmetric unit contains two trimethoprim cations ( A and B), a dipicolinate anion and five water mol­ecules. One of the picolinate carboxyl­ate groups inter­acts with cation A via a pair of N—H⋯O hydrogen bonds, forming a ring motif (8). A loop of O—H⋯O hydrogen bonds is formed between four water mol­ecules and the two carboxyl­ate groups to form a supramolecular chain along the a axis. Mol­ecules A and B constitute a base pair via N—H⋯N hydrogen bonds, and these base pairs are cross-linked by N—H⋯O and C—H⋯O hydrogen bonds. [ABSTRACT FROM AUTHOR]

In the title compound, C4H7N4O2+·SO42−·H2O, the asymmetric unit contains two amino­pyrimidinium cations, a sulfate anion and a water mol­ecule. These species are connected by N—H⋯O and O—H⋯O hydrogen bonds, resulting in a three-dimensional network. [ABSTRACT FROM AUTHOR]

In the crystal structure of the title compound, C6H10N3+·Br−·C6H9N3·H2O, the asymmetric unit contains a 2-amino-4,6-di­methyl­pyrimidinium cation, a Br− anion, a neutral 2-amino-4,6-di­methyl­pyrimidine mol­ecule and a water mol­ecule. Each neutral base molecule is paired with another inversion-related molecule through N—H⋯N hydrogen bonds to form dimers, and these are linked to one another through water-mediated hydrogen bonds, generating a supramolecular ribbon. The cations also pair with one another through N—H⋯N hydrogen bonds. The cation pairs are stacked on top of the neutral pairs. The Br− anion also takes part in hydrogen bonding (N/O—H⋯Br). [ABSTRACT FROM AUTHOR]

In the title compound, C4H6N4O·C7H5NO4, there are two types of base-pairing motifs, one involving a pair of N—H...N hydrogen bonds and the other involving a pair of N—H...O hydrogen bonds. These paired molecules are further linked by N—H...O hydrogen bonds to generate DADA and DDAA ( D = donor and A = acceptor) arrays leading to a supramolecular sheet. [ABSTRACT FROM AUTHOR]

In 2,4-diamino-5-( p-chlorophenyl)-6-ethylpyrimidinium hydrogen adipate, C12H14ClN4+·C6H9O4−, the protonated pyrimethamine cation interacts with the carboxylate group of the adipate ion through N—H...O hydrogen bonds, forming a cyclic hydrogen-bonded R22(8) motif. The carboxyl and carboxylate groups of the adipate ions are linked through O—H...O hydrogen bonds in a head-to-tail fashion, forming a chain. Anions and cations are further connected by an extensive network of N—H...O hydrogen bonds. [ABSTRACT FROM AUTHOR]

In the crystal structure of the title compound, C6H10N3+·C7H5O3-, the asymmetric unit contains four crystallographically independent 2-amino-4,6-dimethylpyrimidinium and salicylate ions (Z = 8). In each of these, one of the pyrimidine N atoms is protonated, and the carboxylate group of the salicylate ion interacts with the pyrimidine group through a pair of N—H…O hydrogen bonds, forming an R2²(8) motif. The pyrimidine cations also form base pairs via a pair of N—H…N hydrogen bonds (involving the amino group and the unprotonated ring N atom), forming another R2²(8) motif. Three such R2²(8) motifs, fused together, constitute a closed cyclic aggregate, and the linking of these aggregates, arranged in consecutive layers, can be analysed in terms of off-face stacking interactions. [ABSTRACT FROM AUTHOR]

In the title compounds, namely 2,4-diamino-5-[(3,4,5-trimethoxy­phenyl)methyl]­pyrimidin-1-ium pyridine-2-carboxyl­ate, C14H19N4O3+·C6H4NO2−, (I), and 2-amino-4,6-dimethyl­pyrimidin-1-ium pyridine-2-carboxyl­ate hemihydrate, C6H10N3+·C6H4NO2−·0.5H2O, (II), the trimethoprim and 2-amino-4,6-dimethyl­pyrimidin-1-ium cations are protonated at one of the pyrimidine N atoms. In (I), bifurcated hydrogen bonds are observed between a picolinate O atom, the protonated N atom and the 2-amino group; the graph-set designator is R21(6). The pyrimidine moieties of the trimethoprim cations are centrosymmetrically paired through a pair of N—H⋯N hydrogen bonds. In addition to the base pairing, one of the picolinate O atoms bridges the 2- and 4-amino groups on either side of the paired bases, resulting in a complementary DADA array. In (II), the carboxyl­ate group of the picolinate anion binds with the protonated pyrimidine N atom and the 2-amino group of the pyrimidine moiety through a pair of N—H⋯O hydrogen bonds, leading to the common ring motif R22(8). The water mol­ecule, which resides on a twofold rotation axis, bridges the carboxyl­ate group of the picolinate anion via O—H⋯O hydrogen bonds. [ABSTRACT FROM AUTHOR]

In the title compound [systematic name: 2,4-diamino-5-(3,4,5-trimethoxy­benz­yl)pyrimidinium tetrafluoroborate], C14H19N4O3+·BF4−, the trimethoprim (TMP) mol­ecule is protonated at one of the pyrimidine N atoms. The protonated N atom and 2-amine group of the TMP cation inter­act with the tetrafluoroborate anion through a pair of N—H⋯F hydrogen bonds [graph set R22(8)]. The inversion-related TMP cations are linked through a pair of N—H⋯N hydrogen bonds. The 2-amine group of one TMP cation and the 4-amine group of another cation are bridged by a meth­oxy O atom, via N—H⋯O hydrogen bonds. [ABSTRACT FROM AUTHOR]

The title compound, [Sr(C9H5INO4S2)2(H2O)2]·H2O, is isomorphous with the corresponding calcium complex of ferron (8-hydroxy-7-iodo­quinoline-5-sulfonic acid). The asymmetric unit consists of one SrII ion, two organic ligands, two coordinated water mol­ecules and one uncoordinated water mol­ecule. The SrII ion has a pentagonal–bipyramidal coordination geometry made up of O atoms of three different sulfonate groups, deprotonated quinolinol O atoms of two different oxine rings and two water mol­ecules. In the ligands of type I, two O atoms of the sulfonate group are involved in coordination, whereas in type II ligands, only one O atom is involved. Ligands of type I are stacked on top of one another, each pair of adjacent members of the stack being related by an inversion centre. Ligands of type II are also stacked in a similar manner. These molecular stacks are cross-linked by Sr—O(sulfonate) and Sr—O(quinolinol) bonds, leading to an extended framework. This architecture is further stabilized by a number of O—H⋯O and N—H⋯O hydrogen bonds. [ABSTRACT FROM AUTHOR]

In the title cocrystal, C6H9N3O2·C7H7NO2, the 2-amino-4,6-dimethoxy­pyrimidine mol­ecule inter­acts with the carboxyl group of the 4-amino­benzoic acid mol­ecule through N—H⋯O and O—H⋯N hydrogen bonds, forming a cyclic hydrogen-bonded motif [ R22(8)]. This motif further self-organizes through N—H⋯O hydrogen bonds to generate an array of six hydrogen bonds with the rings having the graph-set notation R23(6), R22(8), R42(8), R22(8) and R23(6). The 4-amino­benzoic acid mol­ecules self-assemble via N—H⋯O hydrogen bonds to form a supra­molecular chain along the c axis. [ABSTRACT FROM AUTHOR]