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This study explores the fusion of a field-effect transistor (FET), a paper-based analytical cartridge, and the computational power of deep learning (DL) for quantitative biosensing via kinetic analyses. The FET sensors address the low sensitivity challenge observed in paper analytical devices, enabling electrical measurements with kinetic data. The paper-based cartridge eliminates the need for surface chemistry required in FET sensors, ensuring economical operation (cost < $0.15/test). The DL analysis mitigates chronic challenges of FET biosensors such as sample matrix interference, by leveraging kinetic data from target-specific bioreactions. In our proof-of-concept demonstration, our DL-based analyses showcased a coefficient of variation of <6.46% and a decent concentration measurement correlation with an r 2 value of >0.976 for cholesterol testing when blindly compared to results obtained from a CLIA-certified clinical laboratory. These integrated technologies have the potential to advance FET-based biosensors, potentially transforming point-of-care diagnostics and at-home testing through enhanced accessibility, ease-of-use, and accuracy.

Successful integration of point-of-care testing (POCT) into clinical settings requires improved assay sensitivity and precision to match laboratory standards. Here, we show how innovations in amplified biosensing, imaging, and data processing, coupled with deep learning, can help improve POCT. To demonstrate the performance of our approach, we present a rapid and cost-effective paper-based high-sensitivity vertical flow assay (hs-VFA) for quantitative measurement of cardiac troponin I (cTnI), a biomarker widely used for measuring acute cardiac damage and assessing cardiovascular risk. The hs-VFA includes a colorimetric paper-based sensor, a portable reader with time-lapse imaging, and computational algorithms for digital assay validation and outlier detection. Operating at the level of a rapid at-home test, the hs-VFA enabled the accurate quantification of cTnI using 50 μL of serum within 15 min per test and achieved a detection limit of 0.2 pg/mL, enabled by gold ion amplification chemistry and time-lapse imaging. It also achieved high precision with a coefficient of variation of <7% and a very large dynamic range, covering cTnI concentrations over 6 orders of magnitude, up to 100 ng/mL, satisfying clinical requirements. In blinded testing, this computational hs-VFA platform accurately quantified cTnI levels in patient samples and showed a strong correlation with the ground truth values obtained by a benchtop clinical analyzer. This nanoparticle amplification-based computational hs-VFA platform can democratize access to high-sensitivity point-of-care diagnostics and provide a cost-effective alternative to laboratory-based biomarker testing.

This study developed an innovative approach that combines a colourimetric sensor array (CSA) composed of twelve pH-response dyes with advanced algorithms, aiming to detect amine gases and assess the freshness of chilled beef. With the assistance of multivariate statistical analysis, the sensor array can effectively distinguish five amine gases and enable rapid quantification of trimethylamine vapour with a limit of detection (LOD) of 8.02 ppb and visually monitor the fresh levels of chilled beef. Moreover, the utilization of deep learning models (ResNet34, VGG16, and GoogleNet) for chilled beef freshness evaluation achieved an overall accuracy of 98.0 %. Furthermore, t-distributed stochastic neighbour embedding (t-SNE) visualized the feature extraction process and provided explanations to understand the classification process of deep learning. The results demonstrated that applying deep learning techniques in the process of pattern recognition of CSA can help in realizing the rapid, robust, and accurate assessment of chilled beef freshness., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Background: Health-related patient-reported outcomes (HR-PROs) are crucial for assessing the quality of life among individuals experiencing low back pain. However, manual data entry from paper forms, while convenient for patients, imposes a considerable tallying burden on collectors. In this study, we developed a deep learning (DL) model capable of automatically reading these paper forms., Methods: We employed the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire, a globally recognized assessment tool for low back pain. The questionnaire comprised 25 low back pain-related multiple-choice questions and three pain-related visual analog scales (VASs). We collected 1305 forms from an academic medical center as the training set, and 483 forms from a community medical center as the test set. The performance of our DL model for multiple-choice questions was evaluated using accuracy as a categorical classification task. The performance for VASs was evaluated using the correlation coefficient and absolute error as regression tasks., Result: In external validation, the mean accuracy of the categorical questions was 0.997. When outputs for categorical questions with low probability (threshold: 0.9996) were excluded, the accuracy reached 1.000 for the remaining 65 % of questions. Regarding the VASs, the average of the correlation coefficients was 0.989, with the mean absolute error being 0.25., Conclusion: Our DL model demonstrated remarkable accuracy and correlation coefficients when automatic reading paper-based HR-PROs during external validation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Multiplexed computational sensing with a point-of-care serodiagnosis assay to simultaneously quantify three biomarkers of acute cardiac injury is demonstrated. This point-of-care sensor includes a paper-based fluorescence vertical flow assay (fxVFA) processed by a low-cost mobile reader, which quantifies the target biomarkers through trained neural networks, all within <15 min of test time using 50 µL of serum sample per patient. This fxVFA platform is validated using human serum samples to quantify three cardiac biomarkers, i.e., myoglobin, creatine kinase-MB, and heart-type fatty acid binding protein, achieving less than 0.52 ng mL -1 limit-of-detection for all three biomarkers with minimal cross-reactivity. Biomarker concentration quantification using the fxVFA that is coupled to neural network-based inference is blindly tested using 46 individually activated cartridges, which shows a high correlation with the ground truth concentrations for all three biomarkers achieving >0.9 linearity and <15% coefficient of variation. The competitive performance of this multiplexed computational fxVFA along with its inexpensive paper-based design and handheld footprint makes it a promising point-of-care sensor platform that can expand access to diagnostics in resource-limited settings., (© 2023 The Authors. Small published by Wiley-VCH GmbH.)

Smartphone has long been considered as one excellent platform for disease screening and diagnosis, especially when combined with microfluidic paper-based analytical devices (μPADs) that feature low cost, ease of use, and pump-free operations. In this paper, we report a deep learning-assisted smartphone platform for ultra-accurate testing of paper-based microfluidic colorimetric enzyme-linked immunosorbent assay (c-ELISA). Different from existing smartphone-based μPAD platforms, whose sensing reliability is suffered from uncontrolled ambient lighting conditions, our platform is able to eliminate those random lighting influences for enhanced sensing accuracy. We first constructed a dataset that contains c-ELISA results (n = 2048) of rabbit IgG as the model target on μPADs under eight controlled lighting conditions. Those images are then used to train four different mainstream deep learning algorithms. By training with these images, the deep learning algorithms can well eliminate the influences of lighting conditions. Among them, the GoogLeNet algorithm gives the highest accuracy (>97%) in quantitative rabbit IgG concentration classification/prediction, which also provides 4% higher area under curve (AUC) value than that of the traditional curve fitting results analysis method. In addition, we fully automate the whole sensing process and achieve the "image in, answer out" to maximize the convenience of the smartphone. A simple and user-friendly smartphone application has been developed that controls the whole process. This newly developed platform further enhances the sensing performance of μPADs for use by laypersons in low-resource areas and can be facilely adapted to the real disease protein biomarkers detection by c-ELISA on μPADs., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

During global outbreaks such as COVID-19, regular nucleic acid amplification tests (NAATs) have posed unprecedented burden on hospital resources. Data of traditional NAATs are manually analyzed post assay. Integration of artificial intelligence (AI) with on-chip assays give rise to novel analytical platforms via data-driven models. Here, we combined paper microfluidics, portable optoelectronic system with deep learning for SARS-CoV-2 detection. The system was quite streamlined with low power dissipation. Pixel by pixel signals reflecting amplification of synthesized SARS-CoV-2 templates (containing ORF1ab, N and E genes) can be real-time processed. Then, the data were synchronously fed to the neural networks for early prediction analysis. Instead of the quantification cycle (C q ) based analytics, reaction dynamics hidden at the early stage of amplification curve were utilized by neural networks for predicting subsequent data. Qualitative and quantitative analysis of the 40-cycle NAATs can be achieved at the end of 22nd cycle, reducing time cost by 45%. In particular, the attention mechanism based deep learning model trained by microfluidics-generated data can be seamlessly adapted to multiple clinical datasets including readouts of SARS-CoV-2 detection. Accuracy, sensitivity and specificity of the prediction can reach up to 98.1%, 97.6% and 98.6%, respectively. The approach can be compatible with the most advanced sensing technologies and AI algorithms to inspire ample innovations in fields of fundamental research and clinical settings., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Medical imaging refers to the process of obtaining images of internal organs for therapeutic purposes such as discovering or studying diseases. The primary objective of medical image analysis is to improve the efficacy of clinical research and treatment options. Deep learning has revamped medical image analysis, yielding excellent results in image processing tasks such as registration, segmentation, feature extraction, and classification. The prime motivations for this are the availability of computational resources and the resurgence of deep convolutional neural networks. Deep learning techniques are good at observing hidden patterns in images and supporting clinicians in achieving diagnostic perfection. It has proven to be the most effective method for organ segmentation, cancer detection, disease categorization, and computer-assisted diagnosis. Many deep learning approaches have been published to analyze medical images for various diagnostic purposes. In this paper, we review the work exploiting current state-of-the-art deep learning approaches in medical image processing. We begin the survey by providing a synopsis of research works in medical imaging based on convolutional neural networks. Second, we discuss popular pretrained models and general adversarial networks that aid in improving convolutional networks' performance. Finally, to ease direct evaluation, we compile the performance metrics of deep learning models focusing on COVID-19 detection and child bone age prediction., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2023 Bagher Sistaninejhad et al.)

Practical human biofluid sensing requires a sensor device to differentiate patients from the normal group with high sensitivity and specificity. Label-free molecular identification from human biofluids allows direct classification of abnormal samples, providing insights for disease diagnosis and finding of new biomarkers. Here, we introduce a label-free surface-enhanced Raman scattering sensor based on a three-dimensional plasmonic coral nanoarchitecture (3D-PCN), which has strong electromagnetic field enhancement through multiple hot spots. The 3D-PCN was synthesized on a paper substrate via direct one-step gold reduction, forming a coral-like nanoarchitecture with high absorption property for biofluids. This was fabricated as a urine test strip and then integrated with a handheld Raman system to develop an on-site urine diagnostic platform. The developed platform successfully classified the human prostate and pancreatic cancer urines in a label-free method supported by two types of deep learning networks, with high clinical sensitivity and specificity. Our technology has the potential to be utilized not only for urinary cancer diagnosis but also for various human biofluid sensing systems as a future point-of-care testing platform., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023. Published by Elsevier B.V.)

A paper-based colourimetric assay for the detection of alanine transaminase has been developed. In the presence of alanine transaminase, 2,4-dinitrophenyl hydrazine changes to pyruvate hydrazone leading to a colour change from pale yellow to dark yellow. Reaction conditions were optimized using absorption spectroscopic studies. Hydrophobic patterns on the Whatman chromatographic paper were created by wax printing, and the reagents were drop cast at the reagent zone. On the paper device, the intensity of the yellow colour increases with ALT concentration in the range of 20-140 U/L in human serum. For the quantification of ALT, coloured images were captured using a digital camera and were processed with Image J software. The machine learning approach was also explored for the ALT analysis by training with colour images of the paper device and testing using a cross-validation procedure. The results obtained with real clinical samples on the paper device showed good accuracy of less than 5% relative error with the clinical lab results. Furthermore, the paper device shows high selectivity to ALT in the presence of various interfering species in blood serum with a sensitivity of 0.261 a.u/(U/L), a detection limit of 4.12 U/L, and precise results with an RSD of less than 7%. For the testing of whole blood, a plasma separation membrane was integrated with the patterned paper., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier B.V. All rights reserved.)

Abstract Purpose Paper-based artifacts hold significant cultural and social values. However, paper is intrinsically fragile to microorganisms, such as mold, due to its cellulose composition, which can serve as a microorganisms’ nutrient source. Mold not only can damage papers’ structural integrity and pose significant challenges to conservation works but also may subject individuals attending the contaminated artifacts to health risks. Current approaches for strain identification usually require extensive training, prolonged time for analysis, expensive operation costs, and higher risks of secondary damage due to sampling. Thus, in current conservation practices with mold-contaminated artifacts, little pre-screening or strain identification was performed before mold removal, and the cleaning techniques are usually broad-spectrum rather than strain-specific. With deep learning showing promising applications across various domains, this study investigated the feasibility of using a convolutional neural network (CNN) for fast in-situ recognition and classification of mold on paper. Methods Molds were first non-invasively sampled from ancient Xuan Paper-based Chinese books from the Qing and Ming dynasties. Strains were identified using molecular biology methods and the four most prevalent strains were inoculated on Xuan paper to create mockups for image collection. Microscopic images of the molds as well as their stains situated on paper were collected using a compound microscope and commercial microscope lens for cell phone cameras, which were then used for training CNN models with a transfer learning scheme to perform the classification of mold. To enable involvement and contribution from the research community, a web interface that actuates the process while providing interactive features for users to learn about the information of the classified strain was constructed. Moreover, a feedback functionality in the web interface was embedded for catching potential classification errors, adding additional training images, or introducing new strains, all to refine the generalizability and robustness of the model. Results & Conclusion In the study, we have constructed a suite of high-confidence classification CNN models for the diagnostic process for mold contamination in conservation. At the same time, a web interface was constructed that allows recurrently refining the model with human feedback through engaging the research community. Overall, the proposed framework opens new avenues for effective and timely identification of mold, thus enabling proactive and targeted mold remediation strategies in conservation.

There is increasing focus on applying deep learning methods to electrocardiograms (ECGs), with recent studies showing that neural networks (NNs) can predict future heart failure or atrial fibrillation from the ECG alone. However, large numbers of ECGs are needed to train NNs, and many ECGs are currently only in paper format, which are not suitable for NN training. We developed a fully-automated online ECG digitisation tool to convert scanned paper ECGs into digital signals. Using automated horizontal and vertical anchor point detection, the algorithm automatically segments the ECG image into separate images for the 12 leads and a dynamical morphological algorithm is then applied to extract the signal of interest. We then validated the performance of the algorithm on 515 digital ECGs, of which 45 were printed, scanned and redigitised. The automated digitisation tool achieved 99.0% correlation between the digitised signals and the ground truth ECG (n = 515 standard 3-by-4 ECGs) after excluding ECGs with overlap of lead signals. Without exclusion, the performance of average correlation was from 90 to 97% across the leads on all 3-by-4 ECGs. There was a 97% correlation for 12-by-1 and 3-by-1 ECG formats after excluding ECGs with overlap of lead signals. Without exclusion, the average correlation of some leads in 12-by-1 ECGs was 60-70% and the average correlation of 3-by-1 ECGs achieved 80-90%. ECGs that were printed, scanned, and redigitised, our tool achieved 96% correlation with the original signals. We have developed and validated a fully-automated, user-friendly, online ECG digitisation tool. Unlike other available tools, this does not require any manual segmentation of ECG signals. Our tool can facilitate the rapid and automated digitisation of large repositories of paper ECGs to allow them to be used for deep learning projects., (© 2022. The Author(s).)

Both the ABO and Rhesus (Rh) blood groups play crucial roles in blood transfusion medicine. Herein, we report a simple and low-cost paper-based analytical device (PAD) for phenotyping red blood cell (RBC) antigens. Using this Rh typing format, 5 Rh antigens on RBCs can be simultaneously detected and macroscopically visualized within 12 min. The proposed Rh phenotyping relies on the presence or absence of hemagglutination in the sample zones after immobilizing the antibodies targeting each Rh antigen. The PAD was optimized in terms of filter paper type, antibodies, and distance of the visualization zone. In this study, the optimal conditions were Whatman filter paper Grade 4; anti-D, -C, -E, -c, and -e antibodies; RBC suspension of 30%; and a visualization zone of 1 cm above the sample zone. The accuracy of simultaneously phenotyping the five Rh RBC antigens in the blood samples (n = 4692) was 99.19%, comparable with the accuracy of the gold-standard tube method used by blood bank laboratories in several regions of Thailand. Furthermore, decision making based on this method can be assisted by deep learning. After implementing a two-stage objective detection algorithm (YOLO v4-tiny) and classification model (DenseNet-201), the ambiguous images (n = 48) were interpreted with 100% accuracy. The PAD integrated with customized-region convolutional neural networks can reduce the interpretation discrepancies in RBC antigen phenotyping in any laboratory., (Copyright © 2022 Elsevier B.V. All rights reserved.)

One of the most popular and well-established forms of payment in use today is paper money. Handling paper money might be challenging for those with vision impairments. Assistive technology has been reinventing itself throughout time to better serve the elderly and disabled people. To detect paper currency and extract other useful information from them, image processing techniques and other advanced technologies, such as Artificial Intelligence, Deep Learning, etc., can be used. In this paper, we present a meticulously curated and comprehensive dataset named ‘NSTU-BDTAKA’ tailored for the simultaneous detection and recognition of a specific object of cultural significance - the Bangladeshi paper currency (in Bengali it is called ‘Taka’). This research aims to facilitate the development and evaluation of models for both taka detection and recognition tasks, offering a rich resource for researchers and practitioners alike. The dataset is divided into two distinct components: (i) taka detection, and (ii) taka recognition. The taka detection subset comprises 3,111 high-resolution images, each meticulously annotated with rectangular bounding boxes that encompass instances of the taka. These annotations serve as ground truth for training and validating object detection models, and we adopt the state-of-the-art YOLOv5 architecture for this purpose. In the taka recognition subset, the dataset has been extended to include a vast collection of 28,875 images, each showcasing various instances of the taka captured in diverse contexts and environments. The recognition dataset is designed to address the nuanced task of taka recognition providing researchers with a comprehensive set of images to train, validate, and test recognition models. This subset encompasses challenges such as variations in lighting, scale, orientation, and occlusion, further enhancing the robustness of developed recognition algorithms. The dataset NSTU-BDTAKA not only serves as a benchmark for taka detection and recognition but also fosters advancements in object detection and recognition methods that can be extrapolated to other cultural artifacts and objects. We envision that the dataset will catalyze research efforts in the field of computer vision, enabling the development of more accurate, robust, and efficient models for both detection and recognition tasks.

Electrocardiography (ECG) is essential in many heart diseases. However, some ECGs are recorded by paper, which can be highly noisy. Digitizing the paper-based ECG records into a high-quality signal is critical for further analysis. We formulated the digitization problem as a segmentation problem and proposed a deep learning method to digitize highly noisy ECG scans. Our method extracts the ECG signal in an end-to-end manner and can handle different paper record layouts. In the experiment, our model clearly extracted the ECG waveform with a Dice coefficient of 0.85 and accurately measured the common ECG parameters with more than 0.90 Pearson's correlation. We showed that the end-to-end approach with deep learning can be powerful in ECG digitization. To the best of our knowledge, we provide the first approach to digitize the least informative noisy binary ECG scans and potentially be generalized to digitize various ECG records., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

AIM: To analyze research hotspots and trends of artificial intelligence in diabetic retinopathy(DR)based on bibliometrics and high-impact papers.METHODS: Papers on artificial intelligence in DR research published in the Web of Science Core Collection(WoSCC)from January 1, 2012, to December 31, 2022 were retrieved. The data was analyzed by CiteSpace software to examine annual publication number, countries, institutions, source journal, research categories, keywords, and to perform an in-depth analysis of high-impact papers.RESULTS: A total of 1 009 papers on artificial intelligence in DR from 79 countries were included in the study, with 272 papers published in 2022. Notably, China and India contributed 287 and 234 papers, respectively. The United Kingdom exhibited a centrality score of 0.31, while the United States boasted an impressive H-index of 48. Three prominent institutions in the United Kingdom(University of London, Moorfields Eye Hospital, and University College London)and one institution in Egypt(Egyptian Knowledge Bank)all achieved a notable H-index of 14. The primary academic disciplines associated with this research field encompassed ophthalmology, computer science, and artificial intelligence. Burst keywords in the years 2021～2022 included transfer learning, vessel segmentation, and convolutional neural networks.CONCLUSION: China emerged as the leading contributor in terms of publication number in this field, while the United States stood out as a key player. Notably, Egyptian Knowledge Bank and University of London assumed leading roles among research institutions. Additionally, IEEE Access was identified as the most active journal within this domain. The research focus in the field of artificial intelligence in DR has transitioned from AI applications in disease detection and grading to a more concentrated exploration of AI-assisted diagnostic systems. Transfer learning, vessel segmentation, and convolutional neural networks hold substantial promise for widespread applications in this field.

This document is a summary of a special issue of the journal Quality & Reliability Engineering International. The issue showcases original research presented at the 2023 International Conference on Quality, Reliability, Risk, Maintenance, and Safety Engineering. The research papers cover a diverse range of topics related to reliability and safety in modern engineering systems. The papers address areas such as reliability modeling and analysis, reliability-based design and optimization, failure/safety analysis and prevention, and maintainability. The authors express their appreciation to the journal and the reviewers for their support and hope that the research presented will be valuable to researchers, engineers, scientists, and students in the field. [Extracted from the article]

In recent years, the research pertaining to speech recognition technology in the Kazakh language has gained significant importance. This is due to the increasing demand for natural language processing applications in the region where Kazakh is predominantly spoken. Thus, there exists an urgent requirement for precise and dependable speech recognition systems. The research study examines the application of sophisticated deep learning methodologies, such as Natural Language Processing (NLP) and Hidden Markov Model (HMM), in facilitating speech recognition for the Kazakh language. Additionally, the investigation delves into how various techniques, including data preprocessing, acoustic modeling, and language modeling, can aid in devising effective speech recognition systems. The article deliberates on the feasible uses of speech recognition technology in the geographic area where Kazakh language is spoken and outlines its future research prospects. The investigation underscores the significance of persistent inquiry in this realm to confront distinctive obstacles encountered in creating speech recognition systems for languages with restricted resources. [ABSTRACT FROM AUTHOR]

ABSTRACTPredictive maintenance strategies are becoming increasingly more important with the increased needs for automation and digitalization within pulp and paper manufacturing sector.Hence, this study contributes to examine the most efficient pre-processing approaches for predicting sensory data trends based on Gated Recurrent Unit (GRU) neural networks. To validate the model, the data from two paper pulp presses with several pre-processing methods are utilized for predicting the units’ conditions. The results of validation criteria show that pre-processing data using a LOWESS in combination with the Elimination of discrepant data filter achieves more stable results, the prediction error decreases, and the predicted values are easier to interpret. The model can anticipate future values with MAPE, RMSE and MAE of 1.2, 0.27 and 0.30 respectively. The errors are below the significance level. Moreover, it is identified that the best hyperparameters found for each paper pulp press must be different.

The automatic semantic structuring of scientific text allows for more efficient reading of research articles and is an important indexing step for academic search engines. Sequential sentence classification is an essential structuring task and targets the categorisation of sentences based on their content and context. However, the potential of transfer learning for sentence classification across different scientific domains and text types, such as full papers and abstracts, has not yet been explored in prior work. In this paper, we present a systematic analysis of transfer learning for scientific sequential sentence classification. For this purpose, we derive seven research questions and present several contributions to address them: (1) We suggest a novel uniform deep learning architecture and multi-task learning for cross-domain sequential sentence classification in scientific text. (2) We tailor two transfer learning methods to deal with the given task, namely sequential transfer learning and multi-task learning. (3) We compare the results of the two best models using qualitative examples in a case study. (4) We provide an approach for the semi-automatic identification of semantically related classes across annotation schemes and analyse the results for four annotation schemes. The clusters and underlying semantic vectors are validated using k-means clustering. (5) Our comprehensive experimental results indicate that when using the proposed multi-task learning architecture, models trained on datasets from different scientific domains benefit from one another. Our approach significantly outperforms state of the art on full paper datasets while being on par for datasets consisting of abstracts. [ABSTRACT FROM AUTHOR]

Background: In low-middle income countries, healthcare providers primarily use paper health records for capturing data. Paper health records are utilized predominately due to the prohibitive cost of acquisition and maintenance of automated data capture devices and electronic medical records. Data recorded on paper health records is not easily accessible in a digital format to healthcare providers. The lack of real time accessible digital data limits healthcare providers, researchers, and quality improvement champions to leverage data to improve patient outcomes. In this project, we demonstrate the novel use of computer vision software to digitize handwritten intraoperative data elements from smartphone photographs of paper anesthesia charts from the University Teaching Hospital of Kigali. We specifically report our approach to digitize checkbox data, symbol-denoted systolic and diastolic blood pressure, and physiological data. Methods: We implemented approaches for removing perspective distortions from smartphone photographs, removing shadows, and improving image readability through morphological operations. YOLOv8 models were used to deconstruct the anesthesia paper chart into specific data sections. Handwritten blood pressure symbols and physiological data were identified, and values were assigned using deep neural networks. Our work builds upon the contributions of previous research by improving upon their methods, updating the deep learning models to newer architectures, as well as consolidating them into a single piece of software. Results: The model for extracting the sections of the anesthesia paper chart achieved an average box precision of 0.99, an average box recall of 0.99, and an mAP0.5-95 of 0.97. Our software digitizes checkbox data with greater than 99% accuracy and digitizes blood pressure data with a mean average error of 1.0 and 1.36 mmHg for systolic and diastolic blood pressure respectively. Overall accuracy for physiological data which includes oxygen saturation, inspired oxygen concentration and end tidal carbon dioxide concentration was 85.2%. Conclusions: We demonstrate that under normal photography conditions we can digitize checkbox, blood pressure and physiological data to within human accuracy when provided legible handwriting. Our contributions provide improved access to digital data to healthcare practitioners in low-middle income countries. [ABSTRACT FROM AUTHOR]

The detection of ash content in coal slime flotation tailings using deep learning can be hindered by various factors such as foam, impurities, and changing lighting conditions that disrupt the collection of tailings images. To address this challenge, we present a method for ash content detection in coal slime flotation tailings. This method utilizes chromatographic filter paper sampling and a multi-scale residual network, which we refer to as MRCN. Initially, tailings are sampled using chromatographic filter paper to obtain static tailings images, effectively isolating interference factors at the flotation site. Subsequently, the MRCN, consisting of a multi-scale residual network, is employed to extract image features and compute ash content. Within the MRCN structure, tailings images undergo convolution operations through two parallel branches that utilize convolution kernels of different sizes, enabling the extraction of image features at various scales and capturing a more comprehensive representation of the ash content information. Furthermore, a channel attention mechanism is integrated to enhance the performance of the model. The combination of the multi-scale residual structure and the channel attention mechanism within MRCN results in robust capabilities for image feature extraction and ash content detection. Comparative experiments demonstrate that this proposed approach, based on chromatographic filter paper sampling and the multi-scale residual network, exhibits significantly superior performance in the detection of ash content in coal slime flotation tailings. [ABSTRACT FROM AUTHOR]

Over the past decades, tremendous technological advances have emerged in human motion analysis (HMA). How has technology for analysing human motion evolved over the past decades, and what clinical applications has it enabled? The literature on HMA has been extensively reviewed, focusing on three main approaches: Fully-Instrumented Gait Analysis (FGA), Wearable Sensor Analysis (WSA), and Deep-Learning Video Analysis (DVA), considering both technical and clinical aspects. FGA techniques relying on data collected using stereophotogrammetric systems, force plates, and electromyographic sensors have been dramatically improved providing highly accurate estimates of the biomechanics of motion. WSA techniques have been developed with the advances in data collection at home and in community settings. DVA techniques have emerged through artificial intelligence, which has marked the last decade. Some authors have considered WSA and DVA techniques as alternatives to "traditional" HMA techniques. They have suggested that WSA and DVA techniques are destined to replace FGA. We argue that FGA, WSA, and DVA complement each other and hence should be accounted as "synergistic" in the context of modern HMA and its clinical applications. We point out that DVA techniques are especially attractive as screening techniques, WSA methods enable data collection in the home and community for extensive periods of time, and FGA does maintain superior accuracy and should be the preferred technique when a complete and highly accurate biomechanical data is required. Accordingly, we envision that future clinical applications of HMA would favour screening patients using DVA in the outpatient setting. If deemed clinically appropriate, then WSA would be used to collect data in the home and community to derive relevant information. If accurate kinetic data is needed, then patients should be referred to specialized centres where an FGA system is available, together with medical imaging and thorough clinical assessments. • Gait analysis by stereophotogrammetry provides highly accurate biomechanics of motion. • Wearable sensors enable ecological data collection at home and in community setting. • Deep-learning video analysis can perform motion capture without instruments on subjects. • Several authors suggest more modern technologies shall replace traditional gait analysis. • We argue that these three technologies complement each other and shall be "synergistic". [ABSTRACT FROM AUTHOR]

Quantifiable predictability in the citation counts of articles is significant in scientometrics and informetrics. Many metrics based on the citation counts can evaluate the scientific impact of research articles and journals. Utilising time series models, an article's citation counts up to the y th year after publication can be predicted by those up to the previous years. However, the typically used models cannot predict the fat tail of the actual citation distributions. Thus, based on cumulative advantage of the citation behaviour, we propose a method to predict the accumulated citation counts, by using a random number sampled from a power-law distribution to modify the results given by a recurrent neural network (RNN), long short-term memory. Extensive experiments on the data set including 17 journals in information science verified the effectiveness of our method by the good fittings on distributions and evolutionary trends of the citation counts of articles. Our method has the potential to be extended to predict other popular assessment measures such as impact factor and h -index for journals. [ABSTRACT FROM AUTHOR]

Deep learning (DL) requires a large amount of training data to improve performance and prevent overfitting. To overcome these difficulties, we need to increase the size of the training dataset. This can be done by augmentation on a small dataset. The augmentation approaches must enhance the model's performance during the learning period. There are several types of transformations that can be applied to medical images. These transformations can be applied to the entire dataset or to a subset of the data, depending on the desired outcome. In this study, we categorize data augmentation methods into four groups: Absent augmentation, where no modifications are made; basic augmentation, which includes brightness and contrast adjustments; intermediate augmentation, encompassing a wider array of transformations like rotation, flipping, and shifting in addition to brightness and contrast adjustments; and advanced augmentation, where all transformation layers are employed. We plan to conduct a comprehensive analysis to determine which group performs best when applied to brain CT images. This evaluation aims to identify the augmentation group that produces the most favorable results in terms of improving model accuracy, minimizing diagnostic errors, and ensuring the robustness of the model in the context of brain CT image analysis., (© 2024. International Federation for Medical and Biological Engineering.)

There is a growing number of publicly available ophthalmic imaging datasets and open-source code for Machine Learning algorithms. This allows ophthalmic researchers and practitioners to independently perform various deep-learning tasks. With the advancement in artificial intelligence (AI) and in the field of imaging, the choice of the most appropriate AI architecture for different tasks will vary greatly. The best-performing AI-dataset combination will depend on the specific problem that needs to be solved and the type of data available. The article discusses different machine learning models and deep learning architectures currently used for various ophthalmic imaging modalities and for different machine learning tasks. It also proposes the most appropriate models based on accuracy and other important factors such as training time, the ability to deploy the model on clinical devices/smartphones, heatmaps that enhance the self-explanatory nature of classification decisions, and the ability to train/adapt on small image datasets to determine if further data collection is worthwhile. The article extensively reviews the existing state-of-the-art AI methods focused on useful machine-learning applications for ophthalmology. It estimates their performance and viability through training and evaluating architectures with different public and private image datasets of different modalities, such as full-color retinal images, OCT images, and 3D OCT scans. The article is expected to benefit the readers by enriching their knowledge of artificial intelligence applied to ophthalmology., (© 2024. The Author(s).)

Segmentation of glioma is crucial for quantitative brain tumor assessment, to guide therapeutic research and clinical management, but very time-consuming. Fully automated tools for the segmentation of multi-sequence MRI are needed. We developed and pretrained a deep learning (DL) model using publicly available datasets A (n = 210) and B (n = 369) containing FLAIR, T2WI, and contrast-enhanced (CE)-T1WI. This was then fine-tuned with our institutional dataset (n = 197) containing ADC, T2WI, and CE-T1WI, manually annotated by radiologists, and split into training (n = 100) and testing (n = 97) sets. The Dice similarity coefficient (DSC) was used to compare model outputs and manual labels. A third independent radiologist assessed segmentation quality on a semi-quantitative 5-scale score. Differences in DSC between new and recurrent gliomas, and between uni or multifocal gliomas were analyzed using the Mann-Whitney test. Semi-quantitative analyses were compared using the chi-square test. We found that there was good agreement between segmentations from the fine-tuned DL model and ground truth manual segmentations (median DSC: 0.729, std-dev: 0.134). DSC was higher for newly diagnosed (0.807) than recurrent (0.698) (p < 0.001), and higher for unifocal (0.747) than multi-focal (0.613) cases (p = 0.001). Semi-quantitative scores of DL and manual segmentation were not significantly different (mean: 3.567 vs. 3.639; 93.8% vs. 97.9% scoring ≥ 3, p = 0.107). In conclusion, the proposed transfer learning DL performed similarly to human radiologists in glioma segmentation on both structural and ADC sequences. Further improvement in segmenting challenging postoperative and multifocal glioma cases is needed., (© 2024. The Author(s).)

Nowadays many research articles are prefaced with research highlights to summarize the main findings of the paper. Highlights not only help researchers precisely and quickly identify the contributions of a paper, they also enhance the discoverability of the article via search engines. We aim to automatically construct research highlights given certain segments of a research paper. We use a pointer-generator network with coverage mechanism and a contextual embedding layer at the input that encodes the input tokens into SciBERT embeddings. We test our model on a benchmark dataset, CSPubSum, and also present MixSub, a new multi-disciplinary corpus of papers for automatic research highlight generation. For both CSPubSum and MixSub, we have observed that the proposed model achieves the best performance compared to related variants and other models proposed in the literature. On the CSPubSum dataset, our model achieves the best performance when the input is only the abstract of a paper as opposed to other segments of the paper. It produces ROUGE-1, ROUGE-2 and ROUGE-L F1-scores of 38.26, 14.26 and 35.51, respectively, METEOR score of 32.62, and BERTScore F1 of 86.65 which outperform all other baselines. On the new MixSub dataset, where only the abstract is the input, our proposed model (when trained on the whole training corpus without distinguishing between the subject categories) achieves ROUGE-1, ROUGE-2 and ROUGE-L F1-scores of 31.78, 9.76 and 29.3, respectively, METEOR score of 24.00, and BERTScore F1 of 85.25.

The growth of artificial intelligence combined with the collection and storage of large amounts of data in the electronic medical record collection has created an opportunity for orthopedic research and translation into the clinical environment. Machine learning (ML) is a type of artificial intelligence tool well suited for processing the large amount of available data. Specific areas of ML frequently used by orthopedic surgeons performing total joint arthroplasty include tabular data analysis (spreadsheets), medical imaging processing, and natural language processing (extracting concepts from text). Previous studies have discussed models able to identify fractures in radiographs, identify implant type in radiographs, and determine the stage of osteoarthritis based on walking analysis. Despite the growing popularity of ML, there are limitations including its reliance on "good" data, potential for overfitting, long life cycle for creation, and ability to only perform one narrow task. This educational article will further discuss a general overview of ML, discussing these challenges and including examples of successfully published models. [Display omitted] [ABSTRACT FROM AUTHOR]

In recent years, with the development of artificial intelligence, especially deep learning technology, researches on automatic detection of cerebrovascular diseases on medical images have made tremendous progress and these models are gradually entering into clinical practice. However, because of the complexity and flexibility of the deep learning algorithms, these researches have great variability on model building, validation process, performance description and results interpretation. The lack of a reliable, consistent, standardized design protocol has, to a certain extent, affected the progress of clinical translation and technology development of computer aided detection systems. After reviewing a large number of literatures and extensive discussion with domestic experts, this position paper put forward recommendations of standardized design on the key steps of deep learning-based automatic image detection models for cerebrovascular diseases. With further research and application expansion, this position paper would continue to be updated and gradually extended to evaluate the generalizability and clinical application efficacy of such tools.

Paper recommendation with personalized methods helps researchers to track the latest academic trends and master cutting-edge academic trends efficiently. Meanwhile, the methods of previous paper recommendation suffer from three problems: data sparsity of content-based and collaborative filtering methods; Graph-based recommendations do not fully consider the personalized information of authors and their articles; Cold start based on deep learning. To overcome those difficulties, we propose a personalized paper recommendation method based on a knowledge graph and Transformer encoder (KGTE) with a self-attention mechanism. Firstly, we add auxiliary information (article title, publication year, citation times, and abstract) as attributes to the nodes of knowledge graph(KG), which contain author, digital object unique identifier(DOI) and keywords. Secondly, BERT is used to represent the semantic information features of the article and Transformer is introduced to fully integrate the feature context. After that, by using RippleNet, we traverse the knowledge graph, filter the user preference distribution and form a set of pre recommended nodes with multi_hop nodes. Finally, the prediction layer sorts the set and gets a Top_n paper recommendation. In the experiments on the DBLP and Aminer datasets, the precision value of KGTE improved by an average of 2.59% over the existing baseline methods DER and 4.23% improvement in NDCG. [ABSTRACT FROM AUTHOR]

Artificial Intelligence, and Machine Learning especially, are becoming increasingly foundational to our collective future. Recent developments around generative models such as ChatGPT, and DALL-E represent just the tip of the iceberg in new gadgets that will change the way we live our lives. Convolutional Neural Networks (CNNs) and Transformer models are at the heart of advancements in the autonomous vehicles and health care industries as well. Yet these models, as impressive as they are, still make plenty of mistakes without justifying or explaining what aspects of the input or internal state, was responsible for the error. Often, the goal of automation is to increase throughput, processing as many tasks as possible in a short a period of time. For some use cases the cost of mistakes might be acceptable as long as production is increased above some set margin. However, in health care, autonomous vehicles, and financial applications, the cost of a mistake might have catastrophic consequences. For this reason, industries where single mistakes can be costly are less enthusiastic about early AI adoption. The field of eXplainable AI (XAI) has attracted significant attention in recent years with the goal of producing algorithms that shed light into the decision-making process of neural networks. In this paper we show how robust vision pipelines can be built using XAI algorithms with the goal of producing automated watchdogs that actively monitor the decision-making process of neural networks for signs of mistakes or ambiguous data. We call these robust vision pipelines, squinting pipelines.

The research groups in computer vision, graphics, and machine learning have dedicated a substantial amount of attention to the areas of 3D object reconstruction, augmentation, and registration. Deep learning is the predominant method used in artificial intelligence for addressing computer vision challenges. However, deep learning on three-dimensional data presents distinct obstacles and is now in its nascent phase. There have been significant advancements in deep learning specifically for three-dimensional data, offering a range of ways to address these issues. This study offers a comprehensive examination of the latest advancements in deep learning methodologies. We examine many benchmark models for the tasks of 3D object registration, augmentation, and reconstruction. We thoroughly analyse their architectures, advantages, and constraints. In summary, this report provides a comprehensive overview of recent advancements in three-dimensional deep learning and highlights unresolved research areas that will need to be addressed in the future.