Search

Understanding the etiological factors, stress and quality of life have important implications in the management. There is dearth of the literature in this subject, assessing the stress levels in hand eczema and disparities exist in results of the available literature. Primary objective of this study is to assess the clinico-etiological factors in cases of hand eczema. The secondary objectives include to find any correlation between morphological types and the etiological factors, and to determine the role of stress level in these patients. Patients with hand eczema who attended the outpatient department of our tertiary care institution were enrolled in this descriptive study. Sociodemographic and clinico-etiologic data were collected and patch testing of all patients were done. Stress levels were assessed with Perceived stress scale (PSS). Among the 62 patients enrolled, allergic contact dermatitis predominated with 37 (59.7%) cases and patch test was positive in 41 (66.1%). Potassium dichromate was the most common allergen in males, and fragrance mix in females. Significant levels of stress were seen in 67.7% of the subjects. There was no significant correlation between morphological subtypes and the identified aetiologies. Hand eczema is most commonly due to allergic contact dermatitis, and patch testing is helpful in reaching an etiological diagnosis in most of the cases. A large proportion of patients have high stress levels, and hence stress management should also be a part of treatment in addition to traditional treatment., (© 2020 Wiley Periodicals LLC.)

Background: Hand eczema is a common condition; it is often chronic and can be difficult to treat. Cyclosporine is used off-label to treat severe hand eczema; however, the evidence for this treatment is scarce., Objective: To examine the drug survival of cyclosporine in a daily practice cohort of patients with chronic hand eczema., Methods: This retrospective daily use study included hand eczema patients who were treated with cyclosporine between 01-06-1999 and 01-06-2014 in two Dutch university hospitals. Patient and treatment characteristics were retrospectively collected from medical charts. First treatment episodes were analysed by means of Kaplan-Meier drug survival curves. Possible determinants of drug survival were analysed by Cox regression models. Treatment effectiveness was analysed with a retrospective physician's global assessment., Results: A total of 102 patients were treated with cyclosporine. The median drug survival rate was 0.86 years (10.3 months). The overall drug survival rate after 6 months, 1, 2 and 3 years were 61.7%, 45.2%, 18.6% and 13.9% respectively. Main reasons for discontinuation were adverse events, especially early in treatment, and ineffectiveness. After 3 months, a good response to treatment was recorded in 62.9% of the patients., Conclusion: Cyclosporine had a median drug survival of 10.3 months. Especially patients with recurrent vesicular hand eczema showed a good treatment response., (© 2015 European Academy of Dermatology and Venereology.)

We present the case of a 52-year-old woman with a topic dermatitis since adolescence who developed work-related hand eczema, cough and runny nose 12 years after she had started working as a laboratory technician at a precious metals refinery. While skin prick test with sodium hexachloroplatinate (SPTPt ) was negative, patch testing with ammonium tetrachloroplatinate was positive after 24, 48, 72, and 96 hr. Inhalation challenge with sodium hexachloroplatinate yielded cough, mild shortness of breath, and a maximal decrease of FEV1 of 8% from baseline 24 hr after the challenge. Significant increases of bronchial hyperresponsiveness, exhaled nitric monoxide and sputum eosinophils were documented after the challenge. We conclude that eosinophilic airway disease due to platinum salts may occur in SPTPt negative subjects. Both, patch testing and inhalation challenge with platinum salts should be considered in SPT negative subjects with occupational exposure to precious metal salts and work-related allergic symptoms., (© 2015 Wiley Periodicals, Inc.)

Background: Shoe dermatitis is a form of contact dermatitis resulting from exposure to shoes. Allergens and types of shoes responsible may vary depending on manufacturing techniques, climatic conditions and indigenous traditions. This study focuses primarily on as yet unexplored shoe dermatitis cases in Indonesia., Objective: To determine the prevalence of shoe dermatitis in the Dermatology outpatient clinic, Sardjito University Hospital, Yogyakarta, Indonesia over a period of 3 years and to identify the responsible allergens., Methods: All patients meeting screening criteria for possible shoe contact dermatitis were patch tested with the European baseline series, shoe series and additional series based on earlier studies of Indonesian leather and shoe manufacturers; some were also patch tested with their own shoe materials and shoe extracts., Results: Sixty-four (7.1%) of 903 patients with foot skin disorders were diagnosed with shoe dermatitis. Twenty-five (52.1%) of 48 patch-tested patients showed positive reactions to one or more allergens related to footwear. Sixteen patients were patch tested with their own shoe materials; 11 showed positive reactions. The most frequent relevant sensitizers were rubber allergens followed by preservatives, shoe adhesives and leather materials., Conclusion: Shoe dermatitis is common in Indonesia. Using three series of patch tests, we identified responsible allergens and patterns of sensitization in Indonesian shoe dermatitis patients., (© 2015 European Academy of Dermatology and Venereology.)

Occupational hand eczema is frequent in hospital workers, especially in nurses. A comprehensive understanding regarding hand eczema is essential for establishing proper prevention and treatment strategies. The purpose of this study was to identify the risk factors for hand eczema in hospital nursing staffs. A self-administered questionnaire study was performed on hospital nursing staffs at a single general hospital in Korea. In addition, 70 patients with hand eczema underwent patch testing. Five hundred and twenty-five of 700 invited nurses completed the study (response rate, 75.0%). The overall frequency of symptom-based hand eczema was 75.6%, and self-reported hand eczema was 31.0%. Risk factors for hand eczema were young age, history of atopic dermatitis, frequent hand washing (>20 times/day) and long duration of glove wearing (>5 min). Hand eczema was less frequent among frequent hand moisturizer users (>3-4 times/day). Positive patch test reactions were observed in 61.4%. Frequent allergens were nickel sulfate (35.7%), cobalt chloride (28.6%) and thiomersal (21.4%). Among various antibiotics, ciprofloxacin (11.4%), trimethoprim/sulfamethoxazole (11.4%) and gentamicin (7.1%) were revealed as common allergens, in order of frequency. Hand eczema is quite common among hospital nursing staffs. Proper preventive programs and educations are demanded., (© 2013 Japanese Dermatological Association.)

Triclosan is a lypophilic chlorophenol biocide with broad-spectrum antibacterial and antifungal activity. Triclosan-based topical products have been shown to be tolerated and beneficial in atopic dermatitis. The aim of this study was to evaluate the sensitizing potential of triclosan and triclosan-based creams in patients affected by eczematous dermatitis. Two hundred and seventy-five patients affected by chronic eczema (allergic contact dermatitis, irritant contact dermatitis, atopic eczema, nummular eczema, stasis dermatitis) were patch tested with standard patch test series as well as triclosan and triclosan-based products. Standard patch test series resulted positive in 164 patients (61%), with nickel sulfate, house dust mites, fragrance mix, propolis, thimerosal, myroxylon pereira, potassium dichromate, wool alcohols, and p-phenylenediamine the most common sensitizing haptens. Only two patients developed positive reactions to triclosan (0.7%) and four (1.4%) to triclosan-based products. The present study's results confirm that triclosan is well tolerated and has a very low sensitizing potential even in high-risk patients affected by eczema.

Aim: To evaluate common methods of investigation and treatment in children younger than 2 y of age with eczema, with or without sensitization to food allergens., Methods: One hundred and twenty-three children younger than 2 y of age with eczema and suspected food allergy were included in this prospective study. The children underwent skin-prick test with cow's milk, fresh hen's egg white and wheat. Specific IgE to milk and egg white was analysed. The eczema extent and severity was estimated with SCORAD before and after treatment. Children with a positive skin-prick test were instructed to exclude that food item from their diet. All children were treated with emollients and topical steroids when needed., Results: Sixty-two of the children were skin-prick positive to at least one of the allergens; 62% had mild, 30% moderate and 8% severe eczema at their first visit. After treatment, 90% had mild, 10% moderate and 0% severe eczema. Forty-six per cent of the children had circulating IgE antibodies to milk or egg white. Ten per cent had specific IgE but negative skin-prick test to the same allergen. This subgroup improved their eczema significantly without elimination diet., Conclusion: The conventional treatments for children with eczema, i.e. skin care and food elimination, are effective. The beneficial effect of skin care as the first step should not be neglected, and it may not be necessary to eliminate food allergens to relieve skin symptoms in all food-sensitized children with eczema.

One hundred consecutive patients with hand eczema were patch tested with the Indian Standard Series and indigenous antigens after a detailed history and clinical examination. Both sexes were involved and the majority of them were in the age group between 20-39 years (56%). Their occupational profile varied in order of frequency from household work (37%), to masons (14%), students (11%), factory workers (7%), and others (31%). Itching was the most common presenting complaint (93%). A history of atopy was found in 36% of the patients. The predominant sites involved were the palms (43%), followed by fingers (32%), dorsum (17%), and the entire hand (8%). Dry, scaly skin was the most common morphological picture, followed by hyperpigmentation, fissuring, and lichenification. Based on history, clinical examination and patch test results, the diagnosis was made as allergic contact dermatitis in 67% of cases and irritant contact dermatitis in 15% of cases. Positive patch tests with one or more allergens were noted in 67% of the patients. Vegetables (21%) were found to be the most common sensitizers, followed by nickel sulphate (20%), potassium dichromate (18%), and others. Wet work, soaps, and detergents were found to be the most offending irritants. The present study confirmed the fact that hand eczema is a multifactorial disease caused by both irritants and allergens.

Hand eczema is a common skin disease. Because of its variable etiologies and clinical manifestations, it is difficult to determine the etiology from the clinical manifestation. Among the contact allergens, nickel is the most common. Patients with hand eczema and a nickel allergy have a poorer prognosis than patients without a nickel allergy. The reason is still uncertain; suggestions include persistent exposure to nickel or a weak skin barrier. The purpose of our study was to identify the characteristic clinical manifestations by etiology and to compare the skin barrier state between patients with nickel allergies and those without them. Ninety-three patients were classified into 4 types; irritation contact type, allergic contact type, atopic type and mixed type. After the sodium lauryl sulfate (SLS) test to compare the skin barrier state, visual score and transepidermal water loss (TEWL) were measured and analyzed statistically. From this study, it was not possible to ascertain a statistical difference, however a few characteristic clinical manifestations according to etiology can be stated. There was no difference in the visual scoring system or the TEWL after the SLS irritation test between the nickel-allergy group and the non-allergy group. Therefore, we believe that the poor prognosis of hand eczema with nickel allergy may be due to the nickel allergy itself rather than skin barrier state.

A 78-year-old woman suffered a generalized eczematous hypersensitivity reaction following the use of an intranasal budesonide inhaler. Patch testing demonstrated positive reactions to both budesonide and triamcinolone. Her eczema responded to emollients, betamethasone dipropionate ointment and cessation of her intranasal budesonide inhaler.

Patch testing was carried out in 424 schoolchildren (223M, 201F), aged 7-12 years, in northern Norway. In 99 (23.3%) of these children, one or more allergic patch test reactions were demonstrated; 30 children reacted to two and 6 to three or more substances; 53 irritant reactions were recorded in 33 (7.8%) of those tested. From a total of 144 positive tests, the most common allergen was nickel (14.9%), followed by cobalt (5.7%), kathon CG (5.2%), lanolin (1.7%) and neomycin (1.4%). Both allergic and irritant reactions were found twice as frequently in girls as in boys. Positive patch tests were significantly more frequent in atopic (28.8%) than in non-atopic (17.9%) children, being most pronounced in atopic girls (37.4%). Hand eczema was reported to have occurred or to be present in 6.5% of cases. Twenty-nine of 36 children reporting hand eczema participated in the clinical examination. Altogether 15 (3.5%) children had hand eczema at the time of the clinical examination but 12 of these children had no previous history of hand eczema. In 14 of these 15 subjects, the eczema was localized to the back of the hands, with 13 having atopic dermatitis. In 4 of these 15 children, an allergic patch test reaction was found; however, in only 2 of these 4 was the test considered to be clinically relevant for the diagnosis allergic hand eczema. In conclusion, irritant hand eczema may occur in early childhood and is most prevalent in children with atopic dermatitis.

Objective: To analyse the clinical characteristics and sensitivity of an essential oil patch test series (EOS) in patients sensitized to their own essential oils (EOs). Method: We analysed the clinical data and patch test results obtained with the European baseline series (BSE) and an EOS, as well as the mode of use of EOs, through a questionnaire included in the patient file. Results: The study included 42 patients (79% women, average age 50 years) with allergic contact dermatitis (ACD), 8 patients required hospitalization. All patients were sensitized to the EO they used, primarily lavender (Lavandula augustifolia, 8000‐28‐0), tea tree (Melaleuca alternifolia leaf oil, 68647‐73‐4), ravintsara (Cinnamomum camphora oil, 92201‐50‐8), and 2 cases were attributed to helichrysum (helichrysum italicum flower absolute, 90045‐56‐0). 71% had positive patch tests to fragrance mix I or II, 9 only to the EOS and 4 only with their personal EO. Interestingly, 40% of patients did not spontaneously mention the use of EOs, and only 33% received advice on their use at the time of purchase. Conclusion: Patch tests with the BSE, limonene and linalool HP, and oxidized tea tree oil is sufficient to detect most EO‐sensitized patients. The most important is to test the patient's own used EOs. [ABSTRACT FROM AUTHOR]

This article discusses a case of occupational contact dermatitis in a 44-year-old man who developed a recurrent facial rash after exposure to pyrethrum daisies (Tanacetum cinerariifolium) at his workplace. The man experienced symptoms for 2-4 weeks each summer, which improved but did not completely resolve after 2 months. Patch testing revealed positive reactions to the crop, as well as other substances. The patient was prescribed medication and provided with protective equipment to wear during exposure. The article emphasizes the importance of patch testing for specific allergens to which a patient may be exposed, rather than relying solely on commonly tested allergens. [Extracted from the article]

Contact allergy to skin disinfectants is not often recognized in children. We report the cases of six children (1–16.5 years old) with allergic contact dermatitis to ingredients commonly contained in commercial antiseptic and cosmetic products. Patch test responses to chlorhexidine, benzyl alcohol, and benzalkonium chloride varied from one child to another one, but most children were sensitized to at least two components. In several of the cases, exposure had initially occurred in the neonatal period, but diagnosis occurred only after multiple reactions of increasing severity. [ABSTRACT FROM AUTHOR]

Patients with patch test reactions associated with eye care products: Retrospective analysis of North American contact dermatitis group data, 2001-2018 Keywords: allergic contact dermatitis; contact allergy; eye care products; patch tests EN allergic contact dermatitis contact allergy eye care products patch tests 712 715 4 11/18/21 20211201 NES 211201 Eye care products (ECP) may cause allergic contact dermatitis (ACD). Eighty-three of the 154 ECP-positive patients (53.9%) had 99 total reactions to NACDG screening allergens; the remainder (n = 71) had reactions to allergens/substances not on the screening series. [Extracted from the article]

Background: Methyldibromo glutaronitrile (MDBGN) was one of the most frequent and relevant allergens found in patch testing at the beginning of this century. In 2008, this preservative was banned from cosmetics in Europe and ever since the prevalence of contact allergy to MDBGN has progressively decreased. Despite that gradual decline, MDBGN is still patch‐tested in most baseline series. This study assessed the frequency of MDBGN sensitization, epidemiological characteristics of allergic patients, and the relevance of positive patch tests in a nationwide Spanish registry (REIDAC). Patients and methods: We evaluated consecutively patch‐tested patients in all participating centres. Using these data, we calculated the proportion of patients with positive patch tests to MDBGN from June 2018 to June 2020 and evaluated the relevance of the positive patch tests. Results: One hundred and fourteen out of 5072 (2.24 %) tested patients were sensitized to MDBGN. Clinical current relevance was confirmed in only one case. Conclusion: Although the frequency of contact allergy to MDBGN remains high, no clinical significance was found in most of these patients (5072 tests needed to obtain one relevant positive result). The clinical usefulness of this allergen seems weak and its continued inclusion in the European baseline series is questionable. [ABSTRACT FROM AUTHOR]

Keywords: 4-phenylenediamine; dermatitis; allergic contact; drug-related side effects and adverse reactions; immunotherapy; patch tests EN 4-phenylenediamine dermatitis allergic contact drug-related side effects and adverse reactions immunotherapy patch tests 377 379 3 09/08/22 20221001 NES 221001 Abbreviations ACD allergic contact dermatitis CTLA-1 cytotoxic T-lymphocyte associated protein 4 ICP immune check points ICPI immune check point inhibitor IRAE immune-related adverse events MI methylisothiazolinone PD-1 programmed cell death protein 1 PDL1 programmed death ligand 1 PPD para-phenylenediamine Treg T regulatory cells Allergic contact dermatitis (ACD) arising during immune check point inhibitor (ICPI) therapy has rarely been reported and is likely an under-recognized cause of a number of cutaneous immune-related adverse events (IRAE), especially treatment refractory dermatitic eruptions. Dermatitis, allergic contact, drug-related side effects and adverse reactions, 4-phenylenediamine, immunotherapy, patch tests Just as immunosuppression risks false-negative results,7 an immune-enhanced anti-PD-1 state could theoretically cause allergy induction, severe patch test reactions and false positives. [Extracted from the article]

Contact dermatitis in music professionals referred for patch testing: North American Contact Dermatitis Group data, 1996-2018 Keywords: allergic contact dermatitis; contact allergy; music professionals; musicians; patch tests EN allergic contact dermatitis contact allergy music professionals musicians patch tests 359 362 4 08/16/21 20210901 NES 210901 Music professionals (MPs) are at risk for both allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). Allergic contact dermatitis, contact allergy, music professionals, musicians, patch tests. [Extracted from the article]

Allergic contact dermatitis, case report, cosmetics, patch tests A 53-year-old woman experienced a widespread eczema after application of two Tamanu oils on insect bites, with positive patch test results to the two Tamanu oils at 1% in olive oil. Keywords: allergic contact dermatitis; case report; cosmetics; patch tests EN allergic contact dermatitis case report cosmetics patch tests 99 100 2 06/14/22 20220701 NES 220701 Allergic contact dermatitis (ACD) to Tamanu oil is rare, but two recent cases underline that an increase in frequency of use could bring out more cases of ACD to this vegetable oil. [Extracted from the article]

A case study is presented of two male patients, aged 53 years and 58 years, suffering severe dermatitis of the eyelids, lips, and nose along with eczema on the neck. It states both patients worked as laborers in a factory producing polyethylene terephthalate (PET) films after the composition of the powders changed. It mentions patch tests found that N-(4-hydroxyphenyl)benzenesulfonamide (HPBS), an intermediate used in production of PET films, was responsible for the allergic contact dermatitis.

Allergic contact dermatitis, case report, patch tests, benzoic acid, CAS-No. 10310-32-4, serial dilutions, tribenoside Keywords: allergic contact dermatitis; benzoic acid; case report; CAS-No. 10310-32-4; patch tests; serial dilutions; tribenoside EN allergic contact dermatitis benzoic acid case report CAS-No. 10310-32-4 patch tests serial dilutions tribenoside 718 719 2 11/18/21 20211201 NES 211201 CASE REPORT A 48-year-old female patient presented to our clinic with a 2-week history of erythematous and itchy dermatitis around her anus (Figure 1). GLO:FQV/01dec21:cod13952-fig-0001.jpg PHOTO (COLOR): 1 Positive patch tests reactions to Procto-Glyvenol crème gl Patch tests were performed with the European baseline series complemented with lidocaine 5.0% pet., cetyl alcohol 5.0% pet., benzisothiazolinone 0.1% pet. [Extracted from the article]

Second, in our case report, the patch tests with splint scrapings were positive, but only because the splint had been contaminated with the genuine culprit, the diclofenac gel. Allergic contact dermatitis, case report, diclofenac, patch tests, propylene glycol, retained allergen, topical drug Keywords: allergic contact dermatitis; case report; diclofenac; patch tests; propylene glycol; retained allergen; topical drug EN allergic contact dermatitis case report diclofenac patch tests propylene glycol retained allergen topical drug 475 476 2 09/21/21 20211001 NES 211001 CASE REPORT A 45-year-old woman was referred to our department for the investigation of a localized eczema on the right ankle with secondary extension. [Extracted from the article]

Keywords: allergic contact dermatitis; benzoyl peroxide; case report; cosmetics; facial dermatitis; Glycyrrhiza inflata root extract; herbal extracts; liquorice; natural ingredients; patch tests EN allergic contact dermatitis benzoyl peroxide case report cosmetics facial dermatitis Glycyrrhiza inflata root extract herbal extracts liquorice natural ingredients patch tests 454 455 2 09/21/21 20211001 NES 211001 Plant-derived natural ingredients are frequently used in cosmetics. Further patch tests with their individual ingredients kindly provided by the manufacturers were positive to I Glycyrrhiza inflata i (G I inflata i ) root extract 1% alc. from Eucerin Dermopure Oil Control (++ on D4 and D7) and benzoyl peroxide 2.6% pet. from Epiduo (+ on D2, ++ on D4 and + D7) (Figure 1D-G). Allergic contact dermatitis, case report, Glycyrrhiza inflata root extract, benzoyl peroxide, cosmetics, facial dermatitis, liquorice, herbal extracts, natural ingredients, patch tests. [Extracted from the article]

Exposure to hair dye is the most frequent route of sensitisation to para-phenylenediamine ( PPD), a common contact allergen. International studies have examined the profile of PPD, but Australian-sourced information is lacking. Patients are often dissatisfied with advice to stop dyeing their hair. This study examines patients' characteristics, patch test results and outcomes of PPD allergy from a single Australian centre, through a retrospective analysis of patch test data from 2006 to 2013 at the Liverpool Hospital Dermatology Department. It reviews the science of hair dye allergy, examines alternative hair dyes and investigates strategies for hair dyeing. Of 584 patients, 11 were allergic to PPD. Our PPD allergy prevalence rate of 2% is at the lower end of international reported rates. About half these patients also react to para-toluenediamine ( PTD). Affected patients experience a significant lifestyle disturbance. In all, 78% tried alternative hair dyes after the patch test diagnosis and more than half continued to dye their hair. Alternative non- PPD hair dyes are available but the marketplace can be confusing. Although some patients are able to tolerate alternative hair dyes, caution is needed as the risk of developing an allergy to other hair dye ingredients, especially PTD, is high. [ABSTRACT FROM AUTHOR]

The article presents a case study of a 69-year old female who was refereed with eczematous dermatitis affecting the temporal portion of forehead and cheeks. It states that she reported application of honey for cosmetic purpose. It mentions that the reaction to Myroxylon perierae resin was considered to be cross-reaction with propolis.

Allergic contact dermatitis, spongiosis, patch tests, red ink, tattoo Keywords: allergic contact dermatitis; spongiosis; patch tests; red ink; tattoo EN allergic contact dermatitis spongiosis patch tests red ink tattoo 453 454 2 05/06/21 20210601 NES 210601 Complications with red tattoo ink (RTI) can be cutaneous or systemic. [Extracted from the article]

The article presents a case study of a 31-year-old atopic male with eczematous dermatitis in both hands. Topics include the hand disease which was caused by benzisothiazolinone in printing ink and liquid soap; the reported cases of skin diseases that are mostly caused by direct skin contact and the patch test using the European baseline, oil and acrylates series.

A group of 36 normal control persons was patch-tested with glass fibers. The tested filaments had a length of about 3 to 5 mm and a diameter of 9 to 13 µm. The glass fibers were obtained from the normal production process. They were coated with cured epoxy resin. A group of 29 normal control persons was tested with the same type of fibers from which the epoxy finish had been burned off. Another group of 36 persons was patch-tested with ultrasmall glass globes with a diameter of 10 to 15 µm. Coated and uncoated glass globules were tested. On every person 5 patch tests with the same material were done. They were removed after 1, 5, 24, 48 and 72 h. On coated fiber, 12 of 36 tested people reacted with either a + or a ++ reaction. On the uncoated fibers a reaction could be noted in 10 out of 29 persons. The patch tests with coated as well as uncoated glass globules were all negative. A total of 60 biopsies was performed In those cases where + or ++ reactions were noted. The histological examination of the biopsies showed no differences between the reactions on coated and uncoated fibers. The skin reactions to glass fiber showed, besides microtraumatic changes, several histological characteristics of an eczematous reaction, like spongiosis and perivascular lymphocytic infiltration. The importance of these findings is discussed. It is emphasized that histological alterations are only one of the six points which must be taken into account when the diagnosis of eczema is considered. [ABSTRACT FROM AUTHOR]

We have studied a group of 104 patients with pompholyx. to investigate the relationship between allergotogical factors and its etiopathogenesis, The following examinations were performed, blood sampling routine tests and IgE levels. allergological tests (patch, prick. intradennal. and oral renovation tests with nickel sulphate), skin biopsy to exclude pemphigus vulgarism or bullous pemphigoid. An accurate history of familial and personal allergic diathesis was enquired for and various possible aggravating factors (season. microclimate, perspiration and emotional stress) were considered. The results were age `and sex-matched with a healthy control group (208 Subjects). We found familial and personal atopic diathesis in 50% of patients versus 11.5% of controls (P < 0.001); 39 positivity on patch testing 20.19% versus 6.25% of the control group (P<0.001) the % of Patients allergic to nicked reached 26% meluding those (6 Patients) reacting to the oral propagation test season 143 patients) and hyperhidrosis (38) were the aggravating factors most commonly claimed. We detected no correlation between age, sex, grading of pompholyx, and the allergological parameters investigated. Though several different allergological findings have previously been reported indydhidroiss their role in its pathogenses has not yet been fully explained. We think that different haptens or antigens can produce the same clinical and histological picture of pompholyx in predisposed subjects [ABSTRACT FROM AUTHOR]

Of 7887 patients with eczema seen in a private dermatological practice over a period of 2 years and 4 month a specific final diagnosis was found in 5376 (68%), while a final diagnosis of non-specific eczema was made in 2511 cases (32%) The most common final diagnoses were seborrhoeic dermatitis (1351) contact dermatitis (1317), atopic dermatitis (1009) and nummular eczema (822). Battery patch testing was the initial diagnostic procedure performed, and 897 of the 3164 patients who were patch tested had one or more positive patch tests. In 545 cases, the reactions were considered of relevance to the current dermatitis. Tests for immediate-type allergy were carried out in 618 patients, and 284 of these had once or more positive tests. In 86 patients,these test results were of diagnostic significance 257 patients with positive patch tests were challenged orally with the relevant substance , and 53 of 156 reacted to metal salts, most commonly nickel, while 25 of 101 reacted to orally ingested balsam of Peru. Among patch-test-negative patients, 66 of 408 had positive reactions to one or more metal salts; 41 of 180 reacted to balsam of Peru, while 15 of 41 reacted to various food additives. [ABSTRACT FROM AUTHOR]

Hospital cleaning personnel were examined For occupational dermatoses. 356 persons were included in the study. The age ranged from 20 to 63 years with a mean of 40.1 years. The period prevalence rate of moderate and severe eczema was 12% (10% in men and 19% in women). In 88% the eczema was of a duration longer than 2 years. Positive patch tests were found in 10% of men and 53% of women with eczema. The main allergens were nickel, cobalt, chromate and rubber chemicals. Positive tests to cleaning agents were rare. One case of contact allergy to sodium dichloro-iso-cyanurate and one to lysol were diagnosed. Irritant factors played a major role in most cases (92%). Fungus infection as a cause or complication in hand eczema should not be left out of consideration: in 2 persons, a mycosis of hands and/or fingernail was diagnosed. [ABSTRACT FROM AUTHOR]

Nickel is the most important sensitizer in Lagos, with an incidence of 12.3% of 453 patients tested. There was no sex difference, as the wearing of necklaces and bracelets was equally fashionable among both sexes. Housewife eczema is not common, probably because of hardening. Dermatitis from additives in the processing of leather and rubber footwear was the next most common. Chromate sensitivity comes usually from leather or cement. Cultural and climatic factors are mainly responsible for differences in the incidence of contact dermatitis found in Lagos from other countries. [ABSTRACT FROM AUTHOR]

Routine patch testing with a series of 6 industrial biocides containing methylene-bis-thiocyanate (Cytox 3522®), benzisothiazolin-3-one (BIT), chlorocresol (Preventol CMR®), 2-n-octyl-4-isothiazolin-3-one (Kathon 893®), polyhydroxymethylene monobenzylether (Preventol D2®) or 1,3,5-tris (hydroxy-ethyl) hexahydrotriazine (Grotan BK®) was carried out in 6 Danish out-patients clinics to evaluate guinea pig allergy test results with the same compounds. A total of 1652 consecutive patients with dermatitis were tested. The usefulness of this patch test battery was limited. There was a few positive reaction to Cytox 3522® , BIT and the 2-formaldehyde releaser, Preventol D2® and Grotan BK®. These reactions could not however, be explained. The MOAHL-index (% of Male patients from the 6 clinics showed equal frequencies of male patients and atopics, but significant differences in the frequencies of occupational cases, hand eczema, and leg ulcer/ stasis dermatitis, indicating possible variations in referral patterns, use of patch tests, and / or environmental factors. [ABSTRACT FROM AUTHOR]

Forty-eight patients with a positive patch test to potassium dichromate 0.5 % were retested after 4-7 years; 38 patients (79 %) still had a positive patch test. Chromate allergy seems to be persistent. In 72 % of the cases a history of occupational exposure to chromates could be proved. [ABSTRACT FROM AUTHOR]

Delayed reactions to phenylephrine, used as a mydriatic agent during ophthalmological surgical procedures, are well known. We diagnosed a delayed hypersensitivity reaction to phenylephrine included in an ophthalmic insert in a woman presenting, 24 h after surgery, with an acute blepharoconjunctivitis associated with eyelid eczema of the operated eye. The diagnosis was supported by the recognition of clinical symptoms associated with a positive patch test to phenylephrine. Patients who present with previous contact eczema to phenylephrine may develop a generalized eczema if phenylephrine is injected intravenously. Intravenous phenylephrine is increasingly being used in the operating room to treat hypotension. This case report confirms the need for systematic allergological investigation of all drugs and substances administered during the peri-operative period in order to avoid a delayed hypersensitivity reaction occurring after the peri-operative period. Anaesthetists should be aware of the possibility of delayed hypersensitivity reactions involving phenylephrine. [ABSTRACT FROM AUTHOR]

High frequencies of contact allergy to fragrance ingredients have been reported in recent years. Only approximately 70–80% are detected by fragrance allergens in the standard patch test series. This investigation compares the patch test reactions to fine fragrances with reactions to fragrance mix (FM), balsam of Peru (BP) ( Myroxylon pereirae resin) and a fragrance series. 641 consecutive patients with eczema were patch tested with the European standard series and with selected fine fragrances. Those who were positive to 1 of the fine fragrances or the FM or BP were also tested with the fragrance series. 95 (14.8%) patients were found to have a positive patch test reaction to FM or BP; 41 (6.4%) had positive results to fragrance no. 1 and 29 (4.5%) to no. 2. 9 (9.5% of the 95 positive patients) had a positive reaction to fine fragrances and a negative reaction to all other fragrance allergens in the standard series. These findings indicate that testing with fine fragrances can add to our evaluation of fragrance-sensitive patients. [ABSTRACT FROM AUTHOR]

Clinical examinations, patch tests and prick tests were carried out in a group of railwaymen. Only 3 had both eczema and atopy. Prick tests were positive in a high proportion of subjects, including both those with eczema and controls. [ABSTRACT FROM AUTHOR]

Focuses on the diagnosis of an allergic contact dermatitis to naftifine in the abdomen and genitals. Observation of an acute pruritic eczematous eruption developed on the treated areas; Healing of the dermatitis with oral antihistamines, systemic and topical steroids; Assessment of the fungicidal activity of synthetic allylamine derivative against dermatophytes and fungistatic activity toward Candida species.