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Sensitizing potential of triclosan and triclosan-based skin care products in patients with chronic eczema.
- Source :
-
Dermatologic therapy [Dermatol Ther] 2008 Oct; Vol. 21 Suppl 2, pp. S35-8. - Publication Year :
- 2008
-
Abstract
- Triclosan is a lypophilic chlorophenol biocide with broad-spectrum antibacterial and antifungal activity. Triclosan-based topical products have been shown to be tolerated and beneficial in atopic dermatitis. The aim of this study was to evaluate the sensitizing potential of triclosan and triclosan-based creams in patients affected by eczematous dermatitis. Two hundred and seventy-five patients affected by chronic eczema (allergic contact dermatitis, irritant contact dermatitis, atopic eczema, nummular eczema, stasis dermatitis) were patch tested with standard patch test series as well as triclosan and triclosan-based products. Standard patch test series resulted positive in 164 patients (61%), with nickel sulfate, house dust mites, fragrance mix, propolis, thimerosal, myroxylon pereira, potassium dichromate, wool alcohols, and p-phenylenediamine the most common sensitizing haptens. Only two patients developed positive reactions to triclosan (0.7%) and four (1.4%) to triclosan-based products. The present study's results confirm that triclosan is well tolerated and has a very low sensitizing potential even in high-risk patients affected by eczema.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Chronic Disease
Dermatitis, Allergic Contact drug therapy
Dermatitis, Allergic Contact immunology
Dermatitis, Atopic drug therapy
Dermatitis, Atopic immunology
Dermatitis, Irritant drug therapy
Dermatitis, Irritant immunology
Eczema immunology
Emollients administration & dosage
Emollients adverse effects
Female
Haptens immunology
Humans
Infant
Male
Middle Aged
Patch Tests
Young Adult
Anti-Infective Agents, Local administration & dosage
Anti-Infective Agents, Local adverse effects
Eczema drug therapy
Triclosan administration & dosage
Triclosan adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1529-8019
- Volume :
- 21 Suppl 2
- Database :
- MEDLINE
- Journal :
- Dermatologic therapy
- Publication Type :
- Academic Journal
- Accession number :
- 18837732
- Full Text :
- https://doi.org/10.1111/j.1529-8019.2008.00231.x