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Objective To explore the optimal parameters for detecting mitochondrial respiratory function (MRF) in apheresis platelets (AP) using real-time energy metabolism detection technology, and to study the change of MRF in AP during storage. Methods AP samples were collected and detected for MRF using the Seahorse XF device. Multiple parameters such as AP loading concentrations, washing conditions and mitochondrial respiratory regulatory drug concentrations were adjusted. Finally, the MRF in AP stored for 1 and 5 days were studied. Results The optimal parameters for detecting MRF in AP were as follows: The loading concentration was 5×107/100 μL and basal respiration was 316±65; Basal respiration in washing group was 329±120 compared with 57±7 in unwashing group; The concentration of FCCP was 2 μmol/L. The basal respiration in AP for 1 day was 683±161, while was 140±23 for 5 days, P

Background There is a close association between obstructive sleep apnea-hypopnea syndrome (OSAHS) and stroke. The coexistence of the two diseases not only affects the rehabilitation process of patients, prolongs their hospitalization time, but also may increase the risk of death. At present, there is still a lack of clinical research on continuous positive airway pressure (CPAP) combined with respiratory training for stroke patients with OSAHS. Objective To examine the impact of threshold inspiratory muscle training (TIMT) in conjunction with CPAP on sleep status, pulmonary function, and respiratory muscle strength in stroke patients with OSAHS. Methods Sixty-nine patients with stroke and OSAHS who met the enrollment criteria were selected from the Second Affiliated Hospital of Zhengzhou University from April 2022 to August 2023. The patients were divided into experimental group (n=35) and control group (n=34) by random number table method. The control group received CPAP and conventional treatment, and the experimental group received TIMT on this basis for 6 weeks. The sleep status, lung function and respiratory muscle function of the two groups were compared before and after intervention. Results Six weeks after the intervention, the mean blood oxygen saturation (SpO2), proportion of deep sleep (proportion of N3 sleep in total sleep time), minimum arterial oxygen saturation (LSaO2), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), one-second rate (FEV1/FVC), maximum expiratory pressure (MEP) and maximum inspiratory pressure (MIP) were all higher than those before intervention in the 2 groups (P

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Objective To explore the effect of pressure-controlled ventilation-volume guaranteed (PCV-VG) on lung ventilation in elderly patients with pancreatic cancer during operation. Methods A total of 68 elderly patients who underwent elective pancreaticoduodenectomy at The First Affiliated Hospital of Nanjing Medical University from June 2022 to April 2023 were selected as the study subjects. Among them, the V group consisted of 34 patients who received volume-controlled ventilation (VCV) during surgery. The P group consisted of 34 patients who received PCV-VG during surgery. Heart rate (HR) and mean arterial pressure (MAP) of patients were monitored and recorded at five time points: admission (T0), 5 minutes after tracheal intubation (T1), 30 minutes after surgery (T2), 90 minutes after surgery (T3), and end of surgery (T4). The peak airway pressure (Ppeak), mean airway pressure (Pmean), dynamic lung compliance (Cdyn), and tidal volume (VT) of T1-T4 were recorded. T0-T4 arterial blood was collected for blood gas analysis, and PaO2 and PaCO2 were recorded. Results The Ppeak of the P group was lower than that of the V group at all time points (P＜0.05), and the Cdyn was higher than that of the V group (P＜0.05). There was no significant difference in PaO2, PaCO2, HR and MAP between the two groups at each time point (P＞0.05). Conclusion Compared with VCV mode, PCV-VG mode can effectively reduce airway pressure, improve lung compliance, promote gas exchange, and have less impact on respiratory function in elderly patients undergoing pancreaticoduodenectomy.

This article summarized the mechanical ventilation and nursing management for a case of severe asthma complicated with intrinsic positive end-expiratory pressure. The mechanical ventilation was adopted to relieve the symptoms of dyspnea. Comprehensive interventions including vital signs monitoring, noninvasive ventilation nursing, basic nursing, nutrition support, psychological care were carried out to reduce the complication during treatment and improve the recovery of the patient. (本文总结1例重症哮喘合并内源性呼气末正压患者机械通气救治和护理经验。机械通气能有效改善患者呼吸困难的症状, 同时配合病情观察、无创通气护理、基础护理、营养支持以及心理干预等优质护理措施, 积极预防并发症, 促进患者早日康复。)

Objective To investigate the effect of individualized positive end-expiratory pressure (PEEP) ventilation on postoperative pulmonary complications in the patients with prostatic cancer radical operation. Methods A total of 40 patients with elective laparoscopic prostatic cancer radical operation treated in this hospital from August 2021 to February 2022 were divided into the control group(C)and driving pressure guiding group(P)by the random number table method, 20 cases in each group.The group C adopted 5 cm H2O(1 cm H2O=0.098 kPa)of PEEP after tracheal intubation, while the group P underwent once lung re-expansion after tracheal intubation, then with 5 cm H2O as the starting point, increased 1 cm H2O to 15 cm H2O successively, and maintained 10 breathing cycles and the driving pressure was calculated.The corresponding PEEP value at the minimal driving pressure was selected and maintained until the end of the surgery. After the surgery, once lung re-expansion before extubation was conducted.The main observation indicators were the incidence situation of pulmonary complications on postoperative 7 d in both groups, and the secondary observation indicators were the breathing mechanic changes and oxygenation index, etc at each timepoint [immediately after the Trendelenbure position establishment(T0),at 30 min(T1),1 h(T2)and 2 h(T3)after PEEP titration completion, and at 30 min after the operation(T4)].Results Compared with the group C,the extubation time in the group P was significantly shortened, the intraoperative fluid replacement amount and use ratios of vasoactive drugs were significantly increased, PaO2 and OI at T1-4,Ppeak, Pplat, and Cdyn at T1-3 were significantly increased, the driving pressure was significantly decreased, and the differences were statistically significant(P＜0.05). Although the incidence rate of pulmonary complications was decreased on postoperative 7 d, and the difference was not statistically significant(P＞0.05). Conclusion The driving pressure guiding individualized PEEP could improve intraoperative respiratory mechanics in the patients, but there is no statistically significant difference in the incidence rate of postoperative pulmonary complications between the two groups. [ABSTRACT FROM AUTHOR]

This paper summarized the nursing management for a COVID-19 patient with spontaneous pneumothorax caused by pulmonary bulla. Routing nursing care such as medication, isolation, nutrition support, life management were conducted. In addition to conventional nursing, targeted interventions included airway management, drainage nursing, exhaust and sputum excretion management were performed to reduce the risk of complications and improve the recovery of the patient. (本文总结1例肺大疱致自发性气胸并发新型冠状病毒肺炎患者的护理经验。常规护理包括用药、隔离、营养支持、生活管理等方面的措施, 此外, 针对患者病情, 开展呼吸管理、引流管理以及排气、排痰护理, 有效减少相关并发症, 对促进患者康复有积极作用。)

目的 分析卒中后偏瘫患者的膈肌功能，并探讨其与卒中病程以及吞咽、呼吸、运动、平衡功能和日常生活能力的相关性。 方法 本研究为前瞻性研究，连续纳入首次卒中后单侧偏瘫的患者，记录患者的一般资料，洼田饮水试验、主观呼吸功能障碍程度量表、Fugl-Meyer运动功能评定量表（Fugl-Meyer motor function assessment scale，FMA）、Berg平衡量表（Berg balance scale，BBS）、改良Barthel指数（modified Barthel index，mBI）。采用超声测定膈肌功能，包括平静呼吸时的膈肌活动度以及用力呼吸状态下的膈肌活动度和膈肌增厚率。比较整体和不同瘫痪侧患者偏瘫侧和健侧的膈肌功能，分别比较左侧偏瘫和右侧偏瘫患侧的膈肌功能和健侧的膈肌功能。分析瘫痪侧的膈肌功能与病程、洼田饮水试验、主呼吸功能障碍程度量表、FMA、BBS、mBI等指标的相关性 结果 研究共纳入45例卒中患者，其中左侧偏瘫27例（60.00%），右侧偏瘫18例（40.00%）。在整体患者中，用力呼吸状态下，偏瘫侧膈肌活动度（31.69±15.18 mm vs. 40.24±14.66 mm，P＜0.001）及膈肌增厚率（34.99%±23.70% vs. 48.13%±21.98%，P＜0.001）低于健侧。用力呼吸状态下，左侧偏瘫患者的偏瘫侧膈肌活动度（30.13±12.64 mm vs. 44.10±12.95 mm，P＜0.001）和膈肌增厚率（41.20%±23.42% vs. 54.63%±21.08%，P =0.004）较健侧低；右侧偏瘫患者的偏瘫侧膈肌增厚率（25.67%±21.47% vs. 38.37%±20.07%，P =0.005）较健侧低。用力呼吸状态下，右侧偏瘫患者的偏瘫侧膈肌增厚率低于左侧偏瘫患者（P =0.029）。右侧偏瘫患者的健侧膈肌活动度（P =0.028）及膈肌增厚率低于左侧偏瘫患者（P =0.012）。卒中患者平静呼吸状态下，偏瘫侧膈肌活动度与FMA（r =0.362，P =0.015）呈正相关；用力呼吸状态下，偏瘫侧膈肌活动度与洼田饮水试验（r =0.298，P =0.047）、主观呼吸功能障碍程度量表（r =0.437，P =0.003）、FMA（r =0.330，P =0.027）、BBS（r =0.370，P =0.012）、mBI（r =0.321，P =0.031）呈正相关，偏瘫侧膈肌增厚率与病程（r =-0.298，P =0.047）呈负相关。 结论 卒中后偏瘫侧膈肌功能较健侧下降，右侧偏瘫患者双侧膈肌功能较左侧偏瘫患者更差。卒中患者膈肌功能与病程呈负相关，与吞咽功能、呼吸功能、肢体运动功能、平衡能力及日常生活能力呈正相关。 Objective To analyze the changes of diaphragm function with the correlation of diaphragm function with stroke duration, swallowing function, respiratory function, extremity motor function, balance function and daily living ability in stroke patients with hemiplegia. Methods This prospective study enrolled the consecutive patients and unilateral hemiplegia after first stroke. The following data were recorded, including general demographic information, water swallow test (WST) score, subjective respiratory dysfunction scale, Fugl-Meyer motor function assessment (FMA) scale, Berg balance scale (BBS), modified Barthel index (mBI). Diaphragmatic function was measured by ultrasound, including diaphragmatic mobility and during quiet and deep breathing and diaphragm thickening fraction (DTF). The diaphragm function of the hemiplegia and healthy sides among the total patients and different unilateral hemiplegia patients, and between right and left hemiplegia patients were compared. The correlation of diaphragm function of the hemiplegia side with stroke duration, WST score, subjective respiratory dysfunction scale, FMA, BBS, and mBI were analyzed. Results A total of 45 stroke patients were included in the study, with 27 (60.00%) left hemiplegia and 18 (40.00%) right hemiplegia patients. Under deep breathing, for the total patients, the diaphragm mobility (31.69±15.18 mm vs. 40.24±14.66 mm, P

目的 观察中低强度上下肢抗阻训练对卒中慢性期患者呼吸功能、运动耐力及负性情绪的影响。 方法 前瞻性连续入组上海市金山区众仁老年护理医院2019年6月-2020年12月收治的卒中慢性期患者，随机分为研究组和对照组。2组均给予常规康复训练，包括转移训练、功率车训练、平衡及步行能力训练，研究组在此基础上给予中低强度上下肢抗阻训练。以上训练均每次30 min，每日1次，每周5 d，共8周。于治疗前、治疗8周后采用CORTEX心肺功能测试系统评估患者的呼吸功能相关指标，包括用力肺活量（forced vital capacity，FVC）、第1秒用力呼气量（forced expiratory volume in first second，FEV1）、呼气峰值流速（peak expiratory flow，PEF）和FEV1与FVC的比值（FEV1/FVC）；采用6分钟步行测试（si x-minute walk test，6MWT）评估患者运动耐力；采用医院焦虑抑郁量表（hospital anxiety and depression scale，HADS）评估患者焦虑（HADS-A）和抑郁（HADS-D）情绪。比较2组治疗前后上述指标的差异。 结果 研究共入组40例患者，研究组和对照组各20例。治疗前2组基线数据及各项评估指标差异均无统计学意义。治疗后，研究组FVC、FEV1、PEF、6MWT、HADS-A和HADS-D较本组治疗前改善，对照组FVC、FEV1、6MWT较本组治疗前提高，差异有统计学意义。组间比较显示，研究组治疗后FVC[2.73（2.44～3.36）L vs. 2.46（2.22～2.70）L，P =0.035]、FEV1[2.17（1.92～2.68）L vs. 1.94（1.76～2.15）L，P =0.040]及PEF（265.19±34.62 L/min vs. 231.03±33.97 L/mi n，P =0.003）优于对照组，6MWT高于对照组（330.89±52.29 m vs. 299.02±41.85 m，P =0.039），HADS-A（6.25±2.51分 vs. 8.45±4.05分，P =0.040）和HADS-D[6.00（3.00～10.00）分 vs. 9.00（4.00～13.00）分，P =0.036]评分均显著低于对照组。 结论 在常规康复治疗基础上给予中低强度上下肢抗阻训练，在改善卒中慢性期患者的呼吸功能、运动耐力及负性情绪方面有积极的意义。 Objective To observe the effects of resistance training of upper and lower limbs on respiratory function, exercise endurance and negative emotion in stroke patients at chronic stage. Methods This study prospectively enrolled the consecutive stroke patients at chronic stage who were admitted in Zhongren Geriatric Care Hospital at Jinshan District, Shanghai from June 2019 to December 2020. All the included patients were randomly divided into observation group and control group. Both groups were given routine rehabilitation training, including transfer training, power vehicle training, balance and walking ability training, and the medium-low intensity resistance training of upper and lower limbs were added in the observation group. The above training was 30 minutes each time, once a day, for 8 weeks (5 days a week). Before treatment and after the treatment for 8 weeks, the respiratory function parameters of all patients were assessed by the German CORTEX cardiopulmonary function test system, including forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), peak expiratory flow rate (PEF) and FEV1/FVC ratio, etc. Exercise endurance was assessed by six-minute walk test (6MWT). The hospital anxiety and depression scale (HADS) was used to assess the patients' emotional state. The above indexes of both groups were compared. Results A total of 40 patients were enrolled in this study, with 20 cases per group. Before treatment, there were no statistical differences in baseline data and observation indexes between the two groups. For comparisons within the groups, after treatment, FVC, FEV1, PEF, 6MWT, HADS-A and HADS-D in the observation group were improved compared with those before treatment, while FVC, FEV1 and 6MWT in the control group were improved compared with those before treatment, with statistical significance for all the above differences. For comparisons between the two groups, FVC [2.73 (2.44-3.36) L vs. 2.46 (2.22-2.70) L, P=0.035], FEV1 [2.17 (1.92-2.68) L vs. 1.94 (1.76-2.15) L, P=0.040] and PEF (265.19±34.62 L/min vs. 231.03±33.97 L/min, P=0.003) in observation group were better than those of control group, 6MWT was higher than that of control group (330.89±52.29 m vs. 299.02±41.85 m, P=0.039), and the scores of HADS-A (6.25±2.51 points vs. 8.45±4.05 points, P=0.040) and HADS-D [6.00 (3.00-10.00) points vs. 9.00 (4.00-13.00) points, P=0.036] were lower than those of the control group. Conclusions On the basis of routine rehabilitation, resistance training of the upper and lower limbs can effectively improve the respiratory function, exercise endurance and negative emotion of stroke patients at chronic stage.

Objective: To investigate the expression of serum mast cell carboxypeptidase (mc-cp) and Th17 in elderly patients with bronchial asthma and their correlation with respiratory function and pulmonary function. Methods: 120 elderly patients with bronchial asthma who were treated in our hospital from April 2018 to August 2021 were selected as the study group (SG), and 100 patients with bronchitis who were treated in our hospital during the same period were selected as the matched group (CG). The differences in serum mc-cp, Th-17, peak expiratory flow rate (PEF), partial pressure of oxygen (PaO2), FEV1 and FEV1/FVC were compared between the two groups, Spearman analysis was carried out on the correlation between the levels of mc-cp and Th-17 and their respiratory and pulmonary functions in the study group. Results: (1) the level of mc-cp in the study group was higher than that in the matched group, and the percentage of Th17 in the study group was also higher than that in the matched group (P<0.05); (2) PEF, PaO2, FEV1 and FEV1/FVC in the study group were lower than those in the matched group (P<0.05); (3) Mc-cp was negatively correlated with PEF and PaO2 in the study group (r=-0.558, -0.700, P<0.001), and Th17 was negatively correlated with PEF and PaO2 in the study group (r=-0.695, -0.774, P<0.001); (4) Mc-cp was negatively correlated with FEV1 and FEV1/FVC in the study group (r=-0.609, -0.481, P<0. 001), and Th17 was negatively correlated with FEV1 and FEV1/FVC in the study group (r=-0.622, -0.561, P<0.001). Conclusion: The levels of serum mc-cp and Th17 in elderly patients with bronchial asthma will increase abnormally, while the respiratory function and pulmonary function will decrease. The correlation analysis shows that the levels of serum mc-cp and Th17 in these patients are negatively correlated with their respiratory function and pulmonary function. [ABSTRACT FROM AUTHOR]

Objective: To observe the effect of preoperative respiratory function training combined with postoperative rapid rehabilitation exercises on respiratory function, quality of life and rehabilitation effect of lung cancer patients undergoing thoracoscopic lobectomy. Methods: Ninety-seven study cases were selected from patients with lung cancer who underwent thoracoscopic lobectomy in our hospital from April 2019 to May 2021. Ninety-seven patients were divided into the control group (48 cases) and the observation group (49 cases) according to the envelope drawing method. The patients in the control group received preoperative respiratory function training and routine surgical rehabilitation training, and the patients in the observation group received postoperative training on the basis of the control group. Fast recovery exercises. The respiratory function, quality of life and rehabilitation effect were compared between the two groups before and 1 week after operation, and the incidence of postoperative complications was compared between the two groups. Results: The forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1) and arterial partial pressure of oxygen (PaO2) in the observation group were higher than those in the control group at 1 week after operation (P<0.05). The arterial partial pressure of carbon dioxide (PaCO2) in the observation group was lower than that in the control group at 1 week after operation (P<0.05). The symptom score of the observation group was lower than that of the control group at 1 week after operation (P<0.05). The scores of functional area and general health status of the observation group at 1 week after operation were higher than those of the control group (P<0.05). The postoperative anal exhaust time, urinary catheter retention time, chest tube retention time and hospital stay of the observation group were shorter than those of the control group (P<0.05). The incidence of postoperative complications in the observation group was lower than that in the control group (P<0.05). CONCLUSION: Preoperative respiratory function training combined with postoperative rapid rehabilitation exercises in lung cancer patients undergoing thoracoscopic lobectomy can promote postoperative rehabilitation, improve their respiratory function, improve their quality of life, and reduce the risk of complications. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Clinical Nursing in Practice is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of China Medical University is the property of Journal of China Medical University Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effect of pneumonia No. 3 combined with honeysuckle in the treatment of children with pneumonia on the respiratory function and inflammatory response level. Methods: A total of 80 children with pneumonia admitted to our hospital from February 2017 to April 2019 were selected and randomly divided into a control group and an observation group, with 40 cases in each group. The children in the control group were treated with azithromycin and the children in the observation group were treated with pneumonia. No. 3 combined with honeysuckle treatment to compare the effects of different treatment methods on the respiratory function and the level of inflammation in children. Results: Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV 1 ), and expiratory peak flow rate (PEF) before treatment in the two groups There was no statistical difference (P>0.05). After treatment, the above-mentioned lung function indexes of the observation group were significantly higher than those of the control group (P<0.05). There was no significant difference in serum tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL-10 between the two groups before treatment (P>0.05). After treatment, the observation group The TNF-α and IL-6 of the children were significantly lower than the control group, and the IL-10 of the observation group was significantly higher than the control group (P<0.05). Comparing the time of rale disappearance, cough relieving time, disappearance time of shortness of breath, heat regression time, and hospitalization time, it was found that the control group was significantly longer than the observation group (P<0.05). In terms of total treatment efficiency, the observation group was significantly higher (P<0.05). Conclusion: The treatment of pneumonia in children with pneumonia No. 3 combined with honeysuckle has a definite effect, which can significantly improve the respiratory function of the children, inhibit the body's inflammatory cytokines, and effectively improve the clinical symptoms of the children, which has certain clinical significance. [ABSTRACT FROM AUTHOR]

To study the effects of minimally invasive pulmonary surfactant (PS) on oxygenation, liver function, kidney function and respiratory function of neonatal respiratory distress syndrome. From March 2018 to March 2019, 66 children with respiratory distress syndrome were selected and divided into observation group (n=33) and control group (n=33) according to the method of random digital table. The children in the control group were treated with routine treatment, while the children in the observation group were treated with minimally invasive PS on the basis of the control group. Arterial blood gas indexes, type II alveolar cell surface antigen (KL-6), macrophage migration inhibitory factor-1 (MIF-1), high mobility group protein 1 (HMGB-1), liver and kidney function, oxygenation index and ventilator parameters were observed and compared between the two groups. After treatment, the partial pressure of oxygen (PaO2), total carbon dioxide (TCO2) and oxygen saturation (SaO2) in both groups were significantly higher than those before treatment, and the above indexes in the observation group were higher than those in the control group. The level of KL-6, MIF-1, HMGB-1 in both groups was significantly lower than that before treatment, and the above indexes in the observation group were lower than those in the control group. The levels of glutamic oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT), urea nitrogen (BUN), creatine (CRE) in both groups were significantly lower than those before treatment, and the above indexes in the observation group were significantly lower than those in the control group. The ventilator parameters and oxygenation index of the two groups were observed. It was found that the inhaled oxygen concentration (FiO2), peak inspiratory pressure (PIP), positive end-respiratory pressure (PEEP), and oxygenation index (PaO2/FiO2, OI) in both groups were better than those before treatment, and the above indexes in the observation group were better than those in the control group (P<0.05). Minimally invasive PS is effective in the treatment of neonatal respiratory distress syndrome, which can significantly improve the arterial blood gas index, liver function, kidney function and oxygenation function, reduce the inflammatory reaction and the parameters of mechanical ventilation. [ABSTRACT FROM AUTHOR]

Objective: To compare the effects of thoracic nerve block and intercostal nerve block on hemodynamics, postoperative analgesia and respiratory function in patients undergoing radical mastectomy, and to provide reference for clinical anesthesia selection in patients undergoing radical mastectomy. Methods: 120 patients who received radical mastectomy in our hospital from March 2017 to March 2018 were selected as subjects. They were divided into observation group and control group according to different anesthesia methods, 60 cases in each group. Among them, patients in the observation group were given thoracic nerve block combined with general anesthesia, and patients in the control group were given intercostal nerve block combined with general anesthesia. Compare two groups of patients with postoperative 2h, 6h, 12h, 24h, 48h of static and dynamic visual analogue scale (VAS) score, and compare the two groups of patients before cutting leather 5 min (T0), cut skin instantly (T1), 15 min after the cut leather (T2), 30 min (T3), nail skin instantly (T4) and 15 min after the extubation (T5) hemodynamics and respiratory function indicators, and analyze the two groups of patients with intraoperative medication, use of postoperative analgesia pump, and postoperative adverse reactions. Results: There was no statistically significant difference in VAS scores at different time points in postoperative resting state between the two groups (P>0.05). Under the dynamic state, the VAS score of the observation group was significantly lower than that of the control group (P<0.05). During T1-T5, the average arterial pressure (MAP) and heart rate (HR) in the observation group were significantly lower than those in the control group, and the air volume per minute (MV) was significantly higher than those in the control group (P<0.05). The intraoperative remifentanil consumption, propofol dosage, analgesic pump effective compression times, and remedial analgesia were significantly lower in the observation group than in the control group. Adverse reactions such as nausea and vomiting (PONV), urinary retention, and drowsiness were significantly lower than those in the control group (P<0.05). Conclusion: compared with intercostal nerve block, thoracic nerve block can effectively enhance postoperative analgesic effect, stabilize intraoperative hemodynamics, reduce the amount of opioid, reduce the incidence of adverse reactions, improve postoperative respiratory function, and is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical effect of Ni-Ti shape memory alloy embracing internal fixator in the treatment of patients with multiple rib fractures. Methods: A total of 97 patients with multiple rib fractures, who were admitted to Second People’s Hospital of Anhui Province from January 2016 to January 2018 were selected. The patients were divided into control group(n=47) and study group(n=50) according to the different treatment methods. The control group was treated with the external fixation of the chest protective plate, and the study group was treated with Ni-Ti shape memory alloy embracing internal fixator. The clinical effects of 7 d after operation were compared between the two groups, the pain and respiratory function were compared between the two groups before operation and 7 d after operation, and the occurrence of postoperative complications were recorded in the two groups. Results: The total effective rate[92.00%(46/50)] in the study group, which was higher than that[76.60%(36/47)] in the control group(P<0.05). The visual ana-logue pain scale(VAS) scores in the two groups 7 d after operation were lower than those before operation, and the study group was lower than the control group(P<0.05). The maximum voluntary ventilation percent(MVV%) 7 d after operation in the two groups was higher than that before operation, and the study group was higher than the control group(P<0.05). There was no significant difference in the forced expiratory vital capacity at the 1 st second percent(FEV1%) 7 d after operation between the two groups(P>0.05). The total incidence of postoperative complications [8.00%(4/50)] in the study group was lower than that [23.40%(11/47)] in the control group(P<0.05). Conclusion: Ni-Ti shape memory alloy embracing internal fixator for multiple rib fractures is safe and effective, it can reduce the postoperative pain and improve the respiratory function of the patients, with higher clinical application value. [ABSTRACT FROM AUTHOR]

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Objective To improve the prognosis among patients with respiratory failure poisoned by organophosphorus pesticide though analyzing and discussing the emergency measures and treatment effects. Methods From January 2014 to December 2016，86 patients with respiratory failure caused by severe organophosphorus pesticide poisoning were received in the Emergency Department in Nanchong Central Hospital．The patients were numbered according to the order of the treatment and randomly divided into control group and observation group with 43 cases in each group．All patients were treated with routine emergency measures （gastric lavage and endotracheal intubation，rehydration，and symptomatic treatment） ．The control group was treated with pralidoxime chloride injection and injection of atropine detoxification while the observation group was given pralidoxime chloride combined with Penehyclidine Hydrochloride Injection detoxification．We compared the alleviation of clinical symptoms and the changes of cholinesterase（CHE） and respiratory function （respiratory frequency， Pa02， Pa02 / Fi02） between the two groups of patients 10 min and 30 min after administration. The statistics of atropinization time， blood purification treatment rate， tracheotomy rate， hospital mortality，complications and treatment time were recorded. Results No statistic significance was observed among the two groups of patients in gender，age，weight，body mass index（BMI），the severity of poisoning，types of organophosphorus drugs and blood cholinesterase （CHE） at the first visit （P > 0.05） ．Blood CHE was effectively improved among the two groups 10 min and 30 min after the treatment and significantly higher CHE was seen in the observation group compared to the control group（P < 0.05） . The overall clinical symptom rate was lower 10min and 30min after the treatment （P < 0.05）， and the clinical symptom rate of the observation group was lower than that of the control group （P < 0.05） . The respiratory function indexes （respiratory rate， Pa02， Pa02 / Fi02） were significantly improved 10 min and 30 min after the treatment in both groups compared with those before the treatment （P < 0.05） .The blood purification treatment rate， tracheotomy rate， complication rate， hospitalization time and atropine time of the observation group were significantly lower than those of the control group （P < 0.05） . No significant difference was found in mortality rate between the two groups（ ＞0.05） ．Conclusion After giving effective respiration and circulation support， administration of penehyclidine hydrochloride combined with pralidoxime chloride detoxification can effectively restore the cholinesterase activity among patients with organophosphorus pesticide poisoning and improve respiratory function and prognosis， whichshows a high clinical value. [ABSTRACT FROM AUTHOR]

Objective: To explore the sedative effect of hydrochloride dexmedetomidine combine with remifentanil in the orthopedics surgery and its influence on hemodynamics and respiratory function. Methods: A total of 186 patients, who underwent orthopedics surgery in Tangshan People’s Hospital from March 2016 to May 2017, were selected and randomly divided into observation group（93 cases） and control group（93 cases）. The control group received propofol combined with remifentanil for anesthesia; the observation group received hydrochloride dexmedetomidine combined with remifentanil for anesthesia. The sedative effect between the two groups before treatment（T1）, 10 min after combined use of drugs（T2）, 20 min after combined use of drugs（T3）, 30 min after combined use of drugs（T4） and after the patients were conscious（T5） and hemodynamics and respiratory function were compared, and the incidence of adverse reactions was compared between the two groups. Results: The Alertness/sedation（OAA/S） scores of the two groups at T3 and T4 time points were lower than those at other time points in the two group, and the OAA/S score of the observation group was lower than that of the control group（P<0.05）. There were no significant differences in respiratory rate（RR） and oxygen saturation（SpO2） between the two groups at T1 and T5 time points（P>0.05）. At the time of T2, T3 and T4, the RR and SpO2 of the observation group were higher than those of the control group（P<0.05）. The RR levels of the two groups at T3 and T4 time points were lower than those of the other time points（P<0.05）. There were no significant differences in mean arterial pressure（MAP） and heart rate（HR） between the two groups at each time point（P>0.05）. The incidence of respiratory depression, respiratory tract infarction and nausea and vomiting in the observation group was lower than that in the control group（P<0.05）. Conclusion: Hydrochloride dexmedetomidine combined with remifentanil has a good sedative effect in the orthopedics surgery, with less influence on hemodynamics, mild respiratory depression and good safety. [ABSTRACT FROM AUTHOR]

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Objective: To observe the effect of positive end expiratory pressure (Positive end expiratory pressure, PEEP) of different titration methods on acute respiratory distress syndrome (acute respiratory distress syndrome ARDS (Intra abdominal) with abdominal pressure hypertension, IHA) in patients with respiratory function influence and provide references for the clinical treatment of ARDS patients with IHA in the treatment of positive end expiratory pressure titration. Methods: 64 cases of ARDA patients with IHA admitted in our hospital from January 2015 to January 2016 were selected treated with mechanical ventilation, positive end expiratory pressure control. The patients were divided into two groups according to the PEEP titration in different ways, 32 cases in group A were treated by transpulmonary pressure stretch index guide titration, 32 cases in the group B were treated by lung static pressure volume (P-V) curve predicts pressure titration. The respiratory function indexes of PEEP were compared between the two groups before and after 1D PEEP titration (the pH value, oxygen partial pressure (PaO2), partial pressure of carbon dioxide (PaCO2) and oxygenation index (PaO2/FiO2); tidal volume (VT), peak airway pressure (Ppeak), pplat (Pplat). Positive end expiratory pressure (PEEPtot), static pulmonary compliance (Cst). Results: No statistically significant difference was found in the pH values, PaO2, PaCO2, PaO2/FiO2, VT, Ppeak, Pplat, Cst, PEEPtot, and PEEP between the two groups before PEEP titration (P>0.05). The pH, PaO2, PaO2/FiO2, VT, Cst of both groups after 1 day PEEP titration were significantly increased than those before PEEP titration (P<0.05), the PaCO2, Ppeak, Pplat, PEEPtot were significantly lower (P<0.05). But the Cst VT, 1D, PaO2/FiO2 of group A after 1 day PEEP titration were significantly higher than those of group B (P<0.05), no statistically significant difference was found in the other indicators between two groups(P>0.05). The improvement of Cst, vt, PaO2／FiO2 of patients with grade III and grade II abdominal pressure in group A were significantly higher than those in group B (P＜0.05). Conclusion: The transpulmonary pressure eliminated the effect of chest wall compliance. In the case of chest wall elastic resistance of intra-abdominal hypertension patients increased obviously, guiding PEEP titration could clearly improve the respiratory function of grade II and III intra-abdominal hypertension ARDS patients. Transpulmonary pressure oriented PEEP titration was more suitable and effective way to incure patients with ARDS and IHA. [ABSTRACT FROM AUTHOR]

Objective: To investigate effects of PEEP ventilation on respiratory function and hemodynamics during general anesthesia in patients with bone tumor surgery. Methods: 60 cases of patients with bone tumors were selected during January 2014 to 2015 December in our hospital, all patients were treated with routine anesthesia induction underwent mechanical ventilation, to observe and record the respiratory function and hemodynamic parameters under different PEEP ventilation (0 cmH2O,5 cmH2O and 10 cmH2O). Results: Peak and Plat of PEEP 10 cm H2O were significantly higher than that of PEEP 5 cm H2O and PEEP 0 cm H2O, Peak and Plat of PEEP 5 cm H2O were significantly higher than PEEP 0 cm H2O, the difference was statistically significant (P<0.05). The difference of HR, MAP and CVP of different PEEP levels were no statistical significance (P> 0.05). The difference of CI, SVI, GEF, CFI, SVV, PVV, ITBI, ELWI and PVPI of different PEEP levels were no statistical significance (P>0.05). Conclusion: Increased PEEP values can significantly improve the absorption function such as Peak and Plat, but no influence on hemodynamic, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the effect of fiber bronchoscopy on respiratory function and inflammatory reactions of patients with severe pneumonia and respiratory failure. Methods: 89 cases with severe pneumonia and respiratory failure who were treated in our hospital from September 2013 to September 2015 were selected and according to the different treatment methods, the patients were divided into the research group (47 cases) and the control group (42 cases). The patients in the control group were treated with regular anti-infection treatment, while the patients in the research group were treated with the fiber bronchoscopy and bronchoalveolar lavage besides of the conventional method. Then the Cdyn. PaO2Fi02. WOB and the serum levels of inflammatory factors were observed and compared between the two groups before and after the treatment. Results: Before treatment, there was no statistically significant difference about the Cdyn. WOB. PaO2Fi02. STREM-1, HMGB-1 and CD1 lb+ between the two groups (P>0.05): After treatment, the Cdyn. WOB and PaO2Fi02 in the control group significantly increased (P<0.05): the Cdyn and PaO2 Fi02 in the research group were significantly higher than before treatment, and WOB was significantly lower than before treatment (P<0.05): the Cdyn and PaO> FiO, in the research group were significantly higher than those of the control group, and the WOB was significantly lower than that of the control group (P<0.05): the levels of STREM-1. HMGB-1 and CD1 lb+ in the two groups were significantly lower than before treatment, and the research group was significantly lower than that of the control group, and the differences were statistically significant (P<0.05). Conclusion: Fiber bronchoscopy can improve the respiratory function and the inflammatory reactions of patients with severe pneumonia and respiratory failure. [ABSTRACT FROM AUTHOR]

Copyright of Nursing of Integrated Traditional Chinese & Western Medicine is the property of Journal of Clinical Nursing in Practice (Editorial Board, Shanghai Jiao Tong University Press) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To study the level of serumIL-2 in patients with severe pneumonia and its correlation with respiratory function. Methods: 80 cases of patients with severe pneumonia who were treated in our hospital from May 2013 to May 2015were selected as observation group, 80 cases of patients with general respiratory tract infections were selected as control group. The serum level of IL-2 was detected, and the breath frequency, oxygen partial pressure and oxygen index were detected. Results: The serum IL-2 level of observation group were significantly higher than that of control group (P<0.05); the breathing rate of observation group were significantly higher than that of control group (P<0.05), and the oxygen partial pressure and oxygen index were significantly lower than that of control group (P<0.05). The serum level of IL-2 was positively correlated with breathing rate (P<0.05), negatively correlated with oxygen partial pressure and oxygen index (P<0.05). Conclusions: The level of serum IL-2 is significantly increased in patients with severe pneumonia and closely correlated with respiratory function, it can be used to evaluate patients' respiratory function. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of magnesium sulfate micro pump inhalation in the treatment of children with bronchiolitis and its effect on pulmonary function. Method: Selected 120 cases of children with bronchiolitis who were treated in our hospital from January 2012 to August 2014, which were randomly divided into study group and control group with 60 cases in each group. The two groups were given oxygen inhalation, cough, sputum suction, sedation, anti infection and bronchodilator treatment, the study group were added with 25% magnesium sulfate solution 0.1~0.2 m L/(kg) pump inhalation treatment, compared the clinical curative effect and the changes of pulmonary function between the two groups. Results: The total efficiency of the study group was 98.3%,significantly higher than that 88.3% in the control group(P<0.05). Disappear time of children with cough, shortness of breath, wheezing,pulmonary wheezing/rales and the hospitalization time in the study group was significantly shorter than that of the control group(P<0.05).The tidal volume(VT), time to peak ratio(t PTEF/t E) and(v PTEF/v E) significantly increased and respiratory ratio(Ti/Te) decreased significantly after treatment(P<0.05), the VT, t PTEF/t E and v PTEF/v E of study group were significantly higher than that of the control group, Ti/Te was significantly lower than that of the control group(P<0.05). Conclusion: Magnesium sulfate micro pump inhalation in the treatment of children with bronchiolitis can improve the symptoms such as wheezing, shortness of breath, dyspnea, improve lung function, and the clinical effect is good. [ABSTRACT FROM AUTHOR]

Physiological parameter monitoring is essential to medical staff to evaluate, diagnose and treat patients in neonatal intensive care unit (NICU). Monitoring in NICU includes basic vital signal monitoring and functional monitoring. Basic vital signal monitoring (including ECG, respiration, SpO2, blood pressure, temperature) is advanced and focus on study of usability, continuity and anti-interference. Functional monitoring (including respiratory function, circulatory function, cerebral function) still focus on study of monitoring precision and reliability. Meanwhile, video monitoring and artifact intelligence have presented well performance on improving monitoring precision and anti-interference. In this article, the main parameters and relevant measurement technology for monitoring critical neonates were described.

Objective: To observe the effect of nape cluster acupuncture on swallowing function and respiratory function in patients with post-stroke dysphagia, and to explore its relationship to cerebral arterial flow and neurotrophic factors., Methods: A total of 120 patients with post-stroke dysphagia were randomized into an observation group and a control group, 60 patients in each one. The conventional swallowing rehabilitation therapy and respiratory function training were adopted in the control group. On the basis of treatment in the control group, nape cluster acupuncture was applied at Fengchi (GB 20), Tianzhu (BL 10), Wangu (GB 12), Lianquan (CV 23), Panglianquan (Extra), once a day; pricking blood was applied at Jinjin (EX-HN 12) and Yuye (EX-HN 13), once every 2 days. Both groups were treated for 2 weeks. The therapeutic efficacy was compared between the two groups, and the swallowing function (scores of Kubota water swallowing test, standardized swallowing assessment [SSA] and video fluoroscopic swallowing study [VFSS]), the respiratory function indexes (forced vital capacity [FVC], maximal voluntary ventilation [MVV] and maximal expiratory time), the bilateral cerebral arterial hemodynamics parameters (systolic peak velocity [Vs], mean flow velocity [Vm] and vascular resistance index [RI]) and the serology indexes (brain-derived neurotrophic factor [BDNF], nerve growth factor [NGF] and insulin-like growth factors-1 [IGF-1]) before and after treatment were observed in the both groups., Results: The total effective rate was 80.0% (48/60) in the observation group, which was superior to 60.0% (36/60) in the control group ( P <0.05). After treatment, the scores of Kubota water swallowing test and SSA in the observation group were lower than the control group ( P <0.05), the VFSS score, FVC, MVV and maximal expiratory time were higher than the control group ( P <0.05). After treatment, the Vs and Vm of bilateral cerebral artery and serum levels of BDNF, NGF and IGF-1 in the observation group were higher than the control group ( P <0.05), the RI of bilateral cerebral artery was lower than the control group ( P <0.05)., Conclusion: On the basis of the conventional rehabilitation training, nape cluster acupuncture can effectively improve the swallowing function and respiratory function in patients with post-stroke dysphagia, its mechanism may be related to the improvement of cerebral hemodynamics and the regulation of neurotrophic factors.

Objective: To investigate the status of coal dust hazard classification and lung function damage in a large coal mine in Shanxi Province. Methods: From January to June in 2019, 51 coal dust posts and 598 workers exposed to coal dust were selected from a large coal mine enterprise in Shanxi Province. The coal dust (exhaled dust) samples were collected and tested, and the hazard classification index of coal dust (exhaled dust) was calculated. The jobs exposed to coal dust (exhaled dust) were divided into relatively harmless, mild, moderate and severe hazard posts, and the corresponding workers were divided into relatively harmless group, mild, moderate and severe hazard groups. The forced expiratory volume (FEV1) , forced vital capacity (FVC) and forced expiratory volume/forced vital capacity (FEV1/FVC) in the first second were measured. Spearman rank correlation method was used to analyze the relationship between the hazard grade of coal dust and lung function. Results: Among 51 coal dust (exhalation) posts, 13 coal dust (exhalation dust) exceeded the standard (25.5%) . 168 cases (34.78%) had abnormal pulmonary function. Compared with the relatively harmless group, the proportion of abnormal pulmonary function of workers in mild, moderate and severe hazard groups were higher, FEV1, FVC, FEV1/FVC values were lower, the differences were statistically significant ( P <0.05) . The rank of coal dust (exhaled dust) was negatively correlated with FEV1, FVC and FEV1/FVC ( P <0.01) . Conclusion: Attention should be paid to the supervision and management of relatively harmless and slightly harmful coal dust posts. FVC may be one of the lung function indexes sensitive to coal dust exposure.

To observe the effect of Xiaoqinglong decoction combined with noninvasive ventilation on procalcitonin (PCT), blood gas analysis and respiratory functions in acute exacerbation of chronic obstructive pulmonary disease in the elderly (AECOPD), and investigate its correlation and clinical significance. Eighty-four elderly AECOPD patients with respiratory failure in our hospital from January 2015 to October 2017, were randomly divided into control group and observation group, 42 cases in each group. The control group received western medicine combined with noninvasive ventilator therapy, and the patients in observation group additionally received Xiaoqinglong decoction on the basis of the treatment in control group. Both groups were treated for 2 weeks. The clinical effects of two groups were observed and their PCT, blood gas analysis outcomes [arterial oxygen partial pressure (PaO₂), arterial partial pressure of carbon dioxide (PaCO₂), respiratory function, forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), FEV1/FVC], TCM syndrome score and other indexes and adverse reactions were compared before and after treatment. The total efficiency was 95.24% (40/42) in observation group, higher than 76.19% (32/42) in control group, with statistically significant difference ( P <0.05). There were no statistically significant differences in PCT, PaO₂, PaCO₂, FVC, FEV1/FVC, FEV1, and TCM syndrome scores between two groups before treatment. But after treatment, PCT and PaCO₂ levels in the observation group were lower and PaO₂, FVC, FEV1/FVC, FEV1 levels was higher than those in the control group ( P <0.05); TCM syndrome scores were lower than those in the control group ( P <0.05); both groups had no obvious adverse reactions. The results showed that Xiaoqinglong decoction combined with noninvasive ventilator could significantly reduce the procalcitonin level, effectively improve the respiratory function and blood gas analysis indexes, and significantly reduce the clinical symptoms in AECOPD patients, so it is worthy of promotion., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Chinese Pharmaceutical Association.)