微创肺表面活性物质对呼吸窘迫综合征新生儿肝肾功能、 氧合功能及呼吸功能的影响.

To study the effects of minimally invasive pulmonary surfactant (PS) on oxygenation, liver function, kidney function and respiratory function of neonatal respiratory distress syndrome. From March 2018 to March 2019, 66 children with respiratory distress syndrome were selected and divided into observation group (n=33) and control group (n=33) according to the method of random digital table. The children in the control group were treated with routine treatment, while the children in the observation group were treated with minimally invasive PS on the basis of the control group. Arterial blood gas indexes, type II alveolar cell surface antigen (KL-6), macrophage migration inhibitory factor-1 (MIF-1), high mobility group protein 1 (HMGB-1), liver and kidney function, oxygenation index and ventilator parameters were observed and compared between the two groups. After treatment, the partial pressure of oxygen (PaO2), total carbon dioxide (TCO2) and oxygen saturation (SaO2) in both groups were significantly higher than those before treatment, and the above indexes in the observation group were higher than those in the control group. The level of KL-6, MIF-1, HMGB-1 in both groups was significantly lower than that before treatment, and the above indexes in the observation group were lower than those in the control group. The levels of glutamic oxaloacetic transaminase (AST), glutamic pyruvic transaminase (ALT), urea nitrogen (BUN), creatine (CRE) in both groups were significantly lower than those before treatment, and the above indexes in the observation group were significantly lower than those in the control group. The ventilator parameters and oxygenation index of the two groups were observed. It was found that the inhaled oxygen concentration (FiO2), peak inspiratory pressure (PIP), positive end-respiratory pressure (PEEP), and oxygenation index (PaO2/FiO2, OI) in both groups were better than those before treatment, and the above indexes in the observation group were better than those in the control group (P<0.05). Minimally invasive PS is effective in the treatment of neonatal respiratory distress syndrome, which can significantly improve the arterial blood gas index, liver function, kidney function and oxygenation function, reduce the inflammatory reaction and the parameters of mechanical ventilation. [ABSTRACT FROM AUTHOR]