老年支气管哮喘患者血清 MC-CP、Th17 的表达 及其与呼吸功能、肺功能的相关性分析.

Objective: To investigate the expression of serum mast cell carboxypeptidase (mc-cp) and Th17 in elderly patients with bronchial asthma and their correlation with respiratory function and pulmonary function. Methods: 120 elderly patients with bronchial asthma who were treated in our hospital from April 2018 to August 2021 were selected as the study group (SG), and 100 patients with bronchitis who were treated in our hospital during the same period were selected as the matched group (CG). The differences in serum mc-cp, Th-17, peak expiratory flow rate (PEF), partial pressure of oxygen (PaO2), FEV1 and FEV1/FVC were compared between the two groups, Spearman analysis was carried out on the correlation between the levels of mc-cp and Th-17 and their respiratory and pulmonary functions in the study group. Results: (1) the level of mc-cp in the study group was higher than that in the matched group, and the percentage of Th17 in the study group was also higher than that in the matched group (P<0.05); (2) PEF, PaO2, FEV1 and FEV1/FVC in the study group were lower than those in the matched group (P<0.05); (3) Mc-cp was negatively correlated with PEF and PaO2 in the study group (r=-0.558, -0.700, P<0.001), and Th17 was negatively correlated with PEF and PaO2 in the study group (r=-0.695, -0.774, P<0.001); (4) Mc-cp was negatively correlated with FEV1 and FEV1/FVC in the study group (r=-0.609, -0.481, P<0. 001), and Th17 was negatively correlated with FEV1 and FEV1/FVC in the study group (r=-0.622, -0.561, P<0.001). Conclusion: The levels of serum mc-cp and Th17 in elderly patients with bronchial asthma will increase abnormally, while the respiratory function and pulmonary function will decrease. The correlation analysis shows that the levels of serum mc-cp and Th17 in these patients are negatively correlated with their respiratory function and pulmonary function. [ABSTRACT FROM AUTHOR]