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In view of the problems that graph-based multi-label feature selection methods ignore the dynamic change of graph Laplacian matrix, as well as such methods employ logical-value labels to guide feature selection process and loses label information, a multi-label feature selection method based on both dynamic graph Laplacian matrix and real-value labels was proposed.The robust low-dimensional space of feature matrix was used to construct a dynamic graph Laplacian matrix, and the robust low-dimensional space was used as the real-value label space.Furthermore, manifold and non-negative constraints were adopted to transform logical labels into real-valued labels to address the issues mentioned above.The proposed method was compared to three multi-label feature selection methods on nine multi-label benchmark data sets in experiments.The experimental results demonstrate that the proposed multi-label feature selection method can obtain the higher quality feature subset and achieve good classification performance.

A robot which redesigned based on the omnibearing level posture robot is introduced. By adding a rotating mechanism on each sole,the redesigned robot can walk on the slope surface,thereby,it can walk on the two special surfaces as horizontal surface,slope surface,and overcome the vertical surface. The modeling of robot is carried out,and calculate the stroke relations among all the legs,the location relations between the robot and the environment,and the gradeability of the robot and so on are analyzed. The simulation analysis of two kinds of contact way and force condition of the key parts while it walks from horizontal surface to slope surface are analyzed by using Solidworks and ADAMS software.

Objective To conduct hazard vulnerability analysis(HVA) in a blood bank, aimed to identify high-risk events and optimize emergency management measures. Methods The risk event evaluation index system was established by referring to the Kaiser model and the situation of Guangzhou Blood Center, and risk events were ranked by risk matrix and Borda count. Results The top five events with the highest risk values identified by Kaiser model were information system emergencies (39.61%), extreme weather (38.03%), major public sentiment (37.86%), public health events (37.37%) and policy changes (37.24%). The results of risk matrix and Borda count revealed 1 extremely high-risk indicator as information system emergency, 5 high-risk indicators with the highest risk being major public sentiment, 11 medium-risk indicators with the highest risk being major medical disputes and 1 low-risk indicator as external fires. Conclusion Conducting HVA in combination with the actual situation of blood banks can effectively identify high-risk events and provide theoretical basis for improving emergency management measures.

Objective To understand the extended care needs of patients with hypertensive intracerebral hemorrhage, investigate the construction methods of extended nursing service and provide reference for clinical nursing practice of hypertensive intracerebral hemorrhage. Methods Totally 150 patients with hypertensive intracerebral hemorrhage were recruited in the study, and their extended care needs were investigated by using self-made questionnaire. Results The total score of patient extended care needs assessment was (108. 29±7. 16), with an average weighted score of (3. 57±0. 68). Professional nursing, self-care and health education were most needed issues in extended care service. Conclusion Patients with hypertensive intracerebral hemorrhage have requirement of professional nursing, self-care and health education in the extended care service. An extended care plan generated by the multidisciplinary team is effective to improve the prognosis and quality of patients after discharge from hospital. (目的 了解高血压性脑出血患者延续性护理服务需求, 探讨延续性护理方案构建, 为开展延续性护理服务提供科学依据。方法 选取2020年1月—2021年6月医院收治的150名高血压脑出血患者为调查对象, 进行问卷调查。结果 对高血压性脑出血患者延续性护理服务需求调查结果进行分析, 患者延续性护理服务需求总分(108. 29±7. 16)分, 条目加权均分(3. 57±0. 68)分, 其中专业护理需求维度、自我护理需求维度和健康教育护理需求维度得分较高。结论 高血压性脑出血患者出院后对于专业护理需求维度、自我护理需求维度和健康教育护理需求较高。通过成立延续性护理小组并制定延续性护理方案, 对改善患者预后和生存质量具有重要意义。)

Facial paralysis is the inability to move the muscles on one or both sides of your face due to nerve damage. Possible causes include inflammation, trauma, stroke or tumors. Timely treatment and nursing interventions are effect to relieve the inflammation and edema and restore facial function. This paper briefly discussed the integrated traditional Chinese and western medicine treatment and nursing strategies for patients with facial paralysis, and provided reference for comprehensive rehabilitation treatment and nursing practice of facial paralysis. (面神经炎是是一组面部表情肌群运动功能障碍性神经系统疾病, 发病原因复杂, 需要及时给予治疗和护理干预, 促使局部炎症水肿消退, 恢复神经机能。本文简要阐述面神经炎中西医结合治疗和护理措施, 旨在为面神经炎综合康复治疗提供参考。)

BackgroundLung cancer is a malignancy of high incidence rate and mortality in China. The fear of relapse can affect the patient's treatment compliance and reduce their quality of life. There have been previous studies on the relationship between fear of lung cancer relapse and disease perception， as well as disease perception and psychological flexibility. However， current research on the status quo of fear of lung cancer relapse and its correlation with illness perception and psychological flexibility is limited.ObjectiveTo explore the fear of cancer relapse and its relations with illness perception and psychological flexibility in patients with lung cancer， and to provide references for subsequent related clinical interventions.MethodsA total of 96 patients were selected as the research subjects， who were pathologically diagnosed with lung cancer and admitted to Fuyang People's Hospital from January 2021 to July 2022. Fear of Progression Questionnaire-Short Form （FoP-Q-SF）， Brief Illness Perception Questionnaire （BIPQ） and Acceptance and Action Questionnaire-Ⅱ （AAQ-Ⅱ） were used for evaluation. Pearson correlation analysis was used to examine the correlation between scores of various scales， and multiple linear regression analysis was used to explore the influencing factors of relapse fear in lung cancer patients.ResultsThe total FoP-Q-SF score of lung cancer patients was （35.35±7.66） and a total of 65 cases （67.71%） had a FoP-Q-SF score≥34. As relevant analyses showed， the BIPQ total score of lung cancer patients was positively correlated with the total score， social family dimension score and physiological health dimension score of Fop-Q-SF （r=0.586， 0.445， 0.475， P

ObjectiveTo evaluate the accuracy of contrast-enhanced ultrasound diagnostic reports for pancreatic lesions.MethodsIn this retrospective study, we included patients who underwent contrast-enhanced ultrasound examination of pancreatic lesions at Peking Union Medical College Hospital from January 2017 to December 2022 and received a confirmed pathological diagnosis. Using pathological diagnosis as the gold standard, the study evaluated the accuracy of contrast-enhanced diagnostic ultrasound. It also analyzed the misdiagnosis of contrast-enhanced ultrasound in diagnosing various pathological types of pancreatic lesions.ResultsOf the 859 patients who met inclusion and exclusion criteria, 489 were male(56.9%) and 370 were female(43.1%).Their age ranged from 16 to 85 years, with a median age of 60(53, 66) years. Except for 47 pancreatic space-occupying lesions that were difficult to categorize as either benign or malignant, a total of 812 cases were included in the diagnostic efficacy analysis of benign and malignant lesions. The results suggested that the diagnostic sensitivity and specificity of contrast-enhanced ultrasound for pancreatic malignant lesions were 98.3%(95% CI: 97.1%-99.1%) and 79.0%(95% CI: 70.1%-86.4%), AUC was 0.887(95% CI: 0.863-0.908), positive and negative predictive value were 96.9%(95% CI: 95.6%-97.9%) and 87.4%(95% CI: 79.6%-92.4%), positive and negative likelihood ratio were 4.69(95% CI: 3.24-6.80) and 0.02(95% CI: 0.01-0.04). The diagnostic accuracy rate of contrast-enhanced ultrasound for diagnosing benign and malignant pancreatic lesions was 95.8%. Of the 859 lesions examined, 48 cases were misdiagnosed by contrast-enhanced ultrasound, with a misdiagnosis rate of 5.6%(48/859), including 7 cases(0.8%) of undetermined diagnosis, while the diagnostic accuracy of pancreatic ductal adenocarcinoma was as high as 98.8%. No complications occurred in any of the patients.ConclusionsContrast-enhanced ultrasound is a safe and effective imaging method for evaluating microvascular perfusion in various pancreatic lesions. It has significant clinical value in diagnosing both benign and malignant pancreatic lesions, particularly in diagnosing pancreatic ductal adenocarcinoma.

Objective Addressing the issues of low control accuracy and poor disturbance rejection in conventional ATO (automatic train operation) speed control algorithms in urban rail transit train operation control systems, a new speed control algorithm is proposed to improve control accuracy. Method Firstly, a single-mass point dynamic equation for train is established, and a delay compensation module is designed to address the phenomenon of delay in executing commands by the traction and braking systems. Secondly, in the controller design part, speed and position errors are collected to establish a sliding mode switching function, and a sliding mode controller is derived through differential equations. Finally, to suppress the inherent oscillation phenomenon of the sliding mode controller, the switching control output is optimized by training a RBF (radial basis function) neural network. Result & Conclusion Simulation experiments are conducted based on the parameters of the train from the Phase II renovation of Xuzhou Metro Line 3 in Matlab software. The simulation results demonstrate that the proposed algorithm ensures that the controller output speed can more efficiently and accurately track the recommended speed curve during train operation.

Objective Urban rail transit generates a considerable amount of energy consumption during operation, with traction energy consumption of train operation offering significant optimization potential. Therefore, there is an urgent need to study a train traction energy-saving control strategy. Method Firstly, a dynamic equation of train operation is established, and the constraint conditions for the train operation process are defined. Secondly, the optimization strategy for train traction energy consumption is decomposed to establish the objective function.Based on the genetic algorithm model, the allocation of train operation energy consumption in different intervals and the optimal cruising speed within intervals are solved. Then, through the cross mutation process of the genetic algorithm, the optimal energy-saving effect of the driving speed recommendation curve is obtained. Finally, a simulation model is built using Matlab software, with real-line train parameters and operational data to simulate the inter-station operation process of the train. Result & Conclusion Experimental results show that the control strategy based on the genetic algorithm model, compared to the conventional fixed working condition sequence control strategies, significantly improves traction energy-saving indicators.

Shazaoyuan granite masses are a substitute location for high-level radioactive waste disposal in China. The widely distributed stochastic discontinuities in the granite bodies in this area are crucial factors that control rock deformation and nuclide migration. The spatial distribution of stochastic discontinuities in the Shazaoyuan granite bodies was examined by considering the outcrop joints and borehole fractures within the range of 600 m×600 m×600 m. First, an analysis of the occurrences of stochastic discontinuities was performed, and the K-means algorithm based on particle swarm optimization was employed to cluster the occurrences. Stochastic discontinuities with dips >65 ° and strikes in the north-northeast (NNE), east-west (EW), and northwest (NW) directions were primarily developed in the rock mass. The dominant sets of borehole cracks were four, namely, 295.4°∠68.3°, 189.5°∠71.2°, 235.6°∠69.2°, and 66.0°∠33.0°, while the dominant sets of outcrop joints were four, namely, 320°∠79 °, 180°∠77°, 282°∠80°, and 231°∠67°, with both sets displaying similar characteristics. Second, planar analysis was performed on the outcrop joints. The Voronoi method was utilized to dissect the rock surface based on the outcrop location. The average trace length value and midpoint surface density value of the outcrop joints were employed to characterize the segmented polygonal rock mass. Based on the calculated values of complete outcrop joints, the average trace lengths in the northeast of the rock mass were about half that in the southwest, whereas the midpoint densities were the highest in the middle of the rock mass. Based on the calculated values of split outcrop joints by the dominant sets, the average trace lengths of the northeast (NE) and NNE oriented discontinuities were longer than those of the other dominant groups. The midpoint plane density values were higher. Finally, a depth analysis of the borehole cracks was performed. Based on the cluster analysis results of the occurrences of borehole cracks, the distribution maps of the strikes and dips of the different dominant sets in borehole cracks with depth were drawn. The borehole cracks demonstrated uneven depth distribution characteristics with an average linear density of 0.11 m–1, reaching the maximum value of 0.60 m–1 in the [−150 m, −160 m] depth, and the NNE cracks were densely developed in the [−310 m, −370 m] depth. This research results provide a reference for selecting better locations for storing high-level radioactive waste in this area.

Hopea chinensis is distributed in China and its seeds are typically reclacitrant. In order to investigate the germination adaptability of seeds to temperature and moisture, we carried out an experiment with three different constant temperatures (15, 20, 25 ℃) controlled by artificial climate incubators, and used six polyethylene glycol (PEG-6000) concentrations (0%, 5%, 10%, 15%, 25% and 35%) to simulate drought stress. The germination characteristics of these seeds were carefully examined. The results were as follows: (1) Temperature exerted a significant influence on seed germination. Regardless of the level of drought stress applied, higher temperatures positively affected the germination percentage, germination energy, germination index, radicle length, sprout length and vitality index of seeds, higher temperatures led to shorter germination delay and increased fluctuations in the germination duration. (2) Drought stress had a significant impact on seed germination. Under identical temperature conditions, increasing levels of drought stress resulted in decreasing of germination percentage, germination energy, germination index, germination duration, radicle length, sprout length and vitality index of seeds. Moreover, higher levels of drought stress led to longer germination delay of seeds. (3) The interaction between temperature and drought stress had a significant influence on seed germination. Under drought stress, seed germination exhibited different responses under different temperature conditions. Specifically, under conditions where a PEG-6000 concentration of 35% was applied as drought stress treatment, the germination percentage at temperatures of 20 ℃ and 25 ℃ were significantly higher than those observed at 15 ℃ (8.89% and 15.55% compared to lower percentage at 15 ℃). However, it was important to note that when subjected to both 35% PEG-6000 and a temperature of 15 ℃, the seeds no longer germinate. In summary, our results indicate that the suitable temperatures for seed germination are identified as being at 20 ℃ and 25 ℃. It is determined that the most favorable temperature for early seedling growth is 25 ℃. As the drought stress intensifies, the inhibitory effect on seed germination become stronger, the effect of drought stress on seed germination is higher than that of temperature. Additionally, moderate warming can help alleviate the inhibitory effect of drought stress on seed germination.

Ottelia cordata is a kind of rare and endangered submerged plant that grows in freshwater wetlands in northern Hainan Island, from Haikou to Wenchang in China. This species is known for its beautiful appearance and the distinct “flower river” landscape, which makes it a high ornamental value. With the intensification of human activities, the habitat of O. cordata has been sharply reduced and fragmented, leading to its endangerment. In order to explore the reproductive characteristics and reproductive laws of O. cordata, the flower morphology, sex ratio, pollen viability, stigma receptivity, reflectance spectrum, pollen limitation and apomixis, and the types and behaviors of pollinators in O. cordata were analyzed. That is, the pollination biology of O. cordata were studied for its further in-situ and ex-situ conservation. The results were as follows: (1) The flowers were dioecism, and the sex ratio of female and male individuals was about 1∶2; the morphologies of male and female flowers were similar, and the female flowers were slightly larger than the male. (2) O. cordata had high pollen viability and stigma receptivity in budding and blooming phases. (3) Apis cerana was the main pollinator of Ottelia cordata, which visited male flowers more frequently than female flowers, with higher pollination efficiency. (4) The distance between the color loci of pistils and stamens was significantly higher than the discrimination threshold of Apis cerana. (5) The fruit setting percentage under natural pollination was similar to that under artificial pollination (95.29% and 98.42%, respectively), and there was no apomixis and low pollen limitation in the natural population of Ottelia cordata. In conclusion, the deceptive pollination of O. cordata simulated by both sexes is imperfect. Pollinators can visually distinguish female and male flowers. However, the large number of male flowers of O. cordata attracted many insects to visit flowers, which increases the probability of “mistake” pollination and is enough for the reproductive needs of female flowers. Therefore, future ex-situ conservation and artificial population restoration should pay more attention to population size, sex ratio and the number of local pollinators.

Molecular dynamics method was used to establish composite wall/inorganic nanopores of three pore sizes, three shale oil systems, five CO2-cosolvent systems, and pure CO2 system. The process of CO2-cosolvent displacement of crude oil in shale nanopores and carbon storage was simulated and the influencing factors of displacement and storage were analyzed. It is shown that the attraction of the quartz wall to shale oil increases with the degree of hydroxylation. The higher the degree of quartz hydroxylation, the more difficult it is to extract the polar components of shale oil. Nanopore size also has a great impact on shale oil displacement efficiency. The larger the pore size, the higher the shale oil displacement efficiency. The closer the cosolvent molecules are to the polarity of the shale oil, the higher the mutual solubility of CO2 and shale oil. The more the non-polar components of shale oil, the lower the mutual solubility of CO2 and shale oil with highly polar cosolvent. Ethyl acetate is more effective in stripping relatively high polar shale oil, while dimethyl ether is more effective in stripping relatively low polar shale oil. Kerogen is highly adsorptive, especially to CO2. The CO2 inside the kerogen is not easy to diffuse and leak, thus allowing for a stable carbon storage. The highest CO2 storage rate is observed when dimethyl ether is used as a cosolvent, and the best storage stability is observed when ethyl acetate is used as a cosolvent.

Objective To study the effect of cordycepin on proliferation, apoptosis and inflammatory reaction of human keratinocyte cell line HaCaT induced by TNF-α. Methods HaCaT cells were divided into control group, model group and intervention groups including low, middle, high dose (cordycepin 25 μmol/L, 50 μmol/L and 100 μmol/L, respectively). HaCaT cells were incubated with by 40 μg/L TNF-α in model group and cordycepin intervention group for 24 hours. Then, the cordycepin intervention groups were incubated with corresponding cordycepin for 24 hours. Cell proliferation was detected by CCK-8 method. Apoptosis was detected by flow cytometry. And mRNA expression of interleukin (IL)-8, IL-1β was detected by RT-qPCR. Results After 24 hours of cordycepin incubation, cell proliferation rate decreased (P＜0.05), cell apoptosis rate increased(P＜0.05)and mRNA expression of IL-8 and IL-1β decreased (P＜0.05). Conclusions Cordycepin can inhibit TNF-α-induced proliferation and inflammatory reaction of HaCaT cells and promote apoptosis of these cells.

Objective To explore the regulative effect and mechanism of cytochrome P450 1A1 (CYP1A1) on regulating lipopolysaccharide (LPS)-induced arginase-1 (Arg-1) expression in macrophages. Methods After mouse macrophage-like cell line RAW264.7 (RAW) was treated with 10 mg/L LPS for 0, 12 and 24 h, respectively (n=3 for each time point), the expression of CYP1A1 and Arg-1 at mRNA and protein levels were measured by RT-PCR and Western blotting. Negative control RAW(NC/RAW) cells, CYP1A1-overexpression RAW (CYP1A1/RAW) cells, CYP1A1-knockout RAW (CYP1A1 KO/RAW) cells and CYP1A1 hydroxylase-activity mutant RAW (CYP1A1m/RAW) cells were constructed, respectively, and then the cells were treated with LPS and further detected with RT-PCR and Western blotting for the expression and activation levels of Arg-1 and signal transducer and activators of transcription-6 (STAT6). Then STAT 6 inhibitor AS1517499 was added to treat the CYP1A1 KO/RAW cells and NC/RAW cells, and the mRNA and protein expression of Arg-1 was measured again after LPS or PBS treatment. CYP1A1 epoxidase inhibitor, nordihydroguaiaretic acid (NDGA) and 12 (S)-HETE were introduced to treat normal RAW cells, the mRNA and protein levels of Arg-1 and activity of STAT6 were detected after LPS or PBS treatment. Results LPS-induced CYP1A1 and Arg-1 were highly expressed in staggering peaks in RAW cells (P < 0.05). Overexpression of CYP1A1 inhibited LPS-induced Arg-1 expression and STAT6 activation in RAW cells, while CYP1A1 knockout enhanced above effects (P < 0.05). STAT6 inhibitor AS1517499 abolished the enhancement of CYP1A1 knockout (P < 0.05). CYP1A1 hydroxylase-activity mutation or 12(S)-HETE simulation had no effect on the expression of Arg-1 (P>0.05), while CYP1A1 epoxidase-activity inhibitor NDGA enhanced Arg-1 expression and STAT6 activation (P < 0.05). Conclusion CYP1A1 can inhibit Arg-1 expression by reducing STAT6 activation in LPS-induced macrophages, and CYP1A1 hydroxylase-activity or its proinflammatory metabolism 12(S)-HETE has no effect on this regulation, while CYP1A1 epoxidase-activity may be involved in this effect.

[Objective] The evolution characteristics and driving capacity of ecological zones in the middle and lower reaches of the Hanjiang River basin were studied in order to provide a scientific basis for the sustainable development of the water ecological environment of this region. [Methods] We used the InVEST model, clustering, and correlation analysis to conduct a multi-year analysis of ecosystem service changes and zoning characteristics based on water environment-related ecosystem services, and to study the association characteristics of ecosystem services and environmental variables within each ecological zoning transfer area. [Results] ① In 2010, 2015, and 2020, the dominant ecological zoning areas were the third, third, and second category areas, respectively, with area shares of 70.54%, 72.92%, and 45.53%. The second category areas had greater water content and soil conservation intensity than the third category areas. ② Correlation analysis showed that rainfall changes were significantly correlated with changes in water conservation and soil conservation intensity. Changes in the areas of agricultural land and construction land for each land use type were significantly correlated with changes in ecosystem services. ③ Regarding the contribution rate of explanatory variables in the areas where ecological zoning shifts occurred, the areas with larger explanatory rates of rainfall changes were mainly located in the central and southern parts of the study area, and the areas with larger explanatory rates of land use changes were mainly located in the western and northwestern parts of the study area. [Conclusion] Rainfall changes had a greater impact on ecosystem services and ecological zoning changes than land use changes. By identifying the key drivers of ecological zoning changes, the stability of ecosystems can be enhanced in the future with targeted optimization of land use type layout or construction of green and gray infrastructure.

[Objective] Against the backdrop of the “dual carbon” initiative, ammonia has emerged as a carbon-free and hydrogen-rich energy carrier with exceptional growth potential. It offers advantages such as high volumetric energy density, and easy liquefaction and storage.However, complex environmental conditions for storage and transmission pose significant risks of corrosion to liquid ammonia tanks and pipelines. Therefore, it is essential to research liquid ammonia corrosion under complex transmission environments to ensure the construction and safe operation of “ammonia-hydrogen” energy infrastructure. [Methods] Through an investigation into the research progress related to liquid ammonia corrosion, this review explored the ammonia corrosion behavior and the mechanisms of stress corrosion cracking of different materials within various environments. Additionally, it provided a comprehensive overview of ammonia corrosion detection techniques and protection measures, along with insights into the future trends in ammonia corrosion research. [Results] This review highlights the following conclusions: The presence of oxygen, carbon oxides, sulfides, and chlorides accelerates ammonia corrosion, while water impurities exhibit a two-sided influence. Stress can potentially lead to stress corrosion cracking in liquid ammonia, with materials such as copper and its alloys being more susceptible, followed by high-strength steel and carbon steel. [Conclusion] To address the need for clarifying the mechanisms of liquid ammonia corrosion behavior and improving ammonia corrosion prevention measures in China, the following recommendations are put forth:(1) Conduct experiments and simulations to study the liquid ammonia corrosion behavior and internal corrosion mechanisms of different materials in the presence of multiple impurities.(2) Carry out critical failure boundary inspections and corrosion risk assessment in the context of pipeline steel and welding consumables with liquid ammonia,taking into consideration the actual transmission environments and material failure characteristics.(3) Establish a comprehensive corrosion control,protection,and evaluation standard system for liquid ammonia storage and transmission,encompassing various aspects such as design,material selection,manufacturing,and operation,and incorporating diverse corrosion prevention measures.

The original monitoring data of dams is the most important data to grasp the operation behavior of the dams,and the outliers in the data are the focus during the analysis.Outliers are divided into two categories.One category is caused by measurement errors and should be eliminated or supplemented to avoid affecting subsequent analysis.The other is caused by structural mutations and should be highly valued.At present,main outlier recognition methods in dam engineering are based on traditional mathematical statistics and do not consider the influence of structural anomalies,which results in low recognition accuracy.Therefore,based on an in-depth study of dam monitoring data and outlier characteristics,this paper first employs robust MM estimation to eliminate the normal influence of internal and external factors and then adopts the residual measured value to eliminate the stable abnormal influence by difference before and after.Finally,according to the minimum value method,outlier identification is conducted on the residual values.The application of the measured dam data proves that the proposed method can identify the measurement outliers more effectively and robustly,and avoid the interference of structural stability anomalies.

Maintenance equipment consumption forecast usually adopts a single prediction model, which has a narrow scope of application and is not accurate in predicting the consumption of complete maintenance equipment. In this paper, the stability consumption characteristics of equipment and maintenance equipment are considered. The comprehensive prediction method of the classification of equipment consumption forecast is carried out. The combination prediction method combines the advantages of the exponential smoothing method, Croston method and TSB method to predict the materials with sTab.consumption and unsTab.consumption respectively. The results verify that the combination forecasting method which avoids the limitation of single forecasting model, has more extensive applicability and improves the accuracy of maintenance material consumption forecasting.

At present, the mainstream cyber security systems are laid out in an alienated style, where security functions are separated from business processes, and security products are isolated from each other.It is difficult to effectively cope with increasingly complicated cyber threats in this architecture.Therefore, it is imperative to move security inward for more resilient and secure network infrastructures.Business scenarios of the cybersecurity sector can be categorized into four perspectives: organization, vendor, regulatory and threat, each of which has different business objectives.Starting from the commonness and individuality of the four perspectives, the needs of this sector was systematically summarized and then the goal of building an extensible cybersecurity capability ecosystem was recognized.As the key to this goal, the intrinsic assurance methodology was proposed.Intrinsic assurance capabilities referred to the abilities of ICT components to natively support security functions such as monitoring, protection and traceability.But intrinsic assurance is not the ultimate security implementation itself, which is a key difference from the existing “endogenous security” or “designed-in security” methodologies.Intrinsic assurance emphasizes the inherent security enabling endowment of network components, whether by activating an innate gift or by encapsulating a given one, both of which logically exhibit autoimmunity from an external viewpoint.One advantage of such a component is the cohesion of business and security, which leads to transparent security posture awareness, customized security policies, and close-fitting security protection.It also simplifies the overall engineering architecture and reduces management complexity through encapsulation of multiple functions into a singleton.Additionally, the Intrinsic Assurance Support Capability Framework was put forward, which summarized and enumerated the security capabilities that conformed to the intrinsic assurance concept.This framework classified the security capabilities into five categories, namely collection, cognition, execution, syndication and resilience respectively, together with their sub-types and underlying ICT technologies.Based on this framework, the enhanced implementations of typical security business scenarios was further introduced in light of intrinsic assurance.

Typhoon landing is frequent in the southeast coastal areas of China, and the typhoon-induced landslide caused by associated rainstorms has caused serious economic losses and casualties. Some studies have made some achievements in the slope hydrological response process and stability analysis of single-peak and multi-peaks typhoon rainstorms, but research on mechanism analysis on the hysteresis effect of typhoon-induced landslide is lacked. Therefore, taking “Lekima” in Qingtian county, Zhejiang Province as an example, based on the statistics of the number and rainfall of typhoon-type landslides, this paper constructs 16 groups of slope models with different structural combinations to simulate the seepage-stability changes of slopes under different rainfall conditions during the landing of a typhoon. The results show that there are still 26.4% landslides in Qingtian county after typhoon “Lekima” left the land, which is lagging. The stability of slopes with different structural combinations is the lowest after landing, which is 13.82% lower than that before typhoon landing. Under the action of typhoon landing rainstorm, the slope is the most sensitive among the influencing parameters of slope stability structure in Qingtian county. It is considered that rainfall at different landing stages of the typhoon will lead to the difference of infiltration characteristics of the slope, thus forming a hysteresis effect. The conclusion has a certain guiding significance for the early identification of typhoon-induced landslides in this area.

To study the extraction rate of soluble dietary fiber (soluble dietary fiber, SDF) contained in the artichoke after ultrafine crushing and high pressure homogenization composite modification, single factor experiment was conducted to investigate the homogenization temperature, homogenization pressure and material concentration on artichoke SDF yield. The response surface method was used to optimize the artichoke SDF extraction process with three factors and three levels. The model between artichoke SDF extraction conditions and yield was established and analyzed to obtain the optimal process parameters and improve the artichoke SDF yield. The results showed that after ultrafine crushing and high pressure homogenization compound modification, the yield of artichoke SDF was significantly affected by the compound modification. The best process for extracting artichoke SDF was a homogenization temperature of 41 ℃ and a homo-genization pressure of 97 MPa, material concentration 2.5%. The theoretical maximum yield of artichoke SDF was 20.70%. With this process, the average yield of artichoke SDF was 20.13%. The Fourier infrared spectroscopy showed that the chemical composition of artichoke dietary fiber had not changed after compound modification.

The effects of two treatments–ultrafine grinding (UG) and freeze-ultrafine-grinding (FUG) on the structure and physicochemical properties of artichoke dietary fiber as dietary fiber (ADF) were investigated. The results showed that the structure of the freeze-ultrafine-grinding artichoke dietary fiber was looser and the particle size was more uniform and concentrated. Compared with non-treated ADF, the D50 values were reduced by 84.63% and 86.72% respectively for the two treatments. In addition, the swelling power, the water holding capacity and the oil holding capacity of the two treatments were increased by 1.22, 1.20, 1.06 times and 1.44, 1.25, 1.97 times, respectively. Moreover, the glucose absorption capacity were increased by 135.09% and 271.09%. And beyond that, the crystallinity of non-treated ADF, UG and FUG were 26.73%, 30.57% and 38.10%. Both UG and FUG improved the physicochemical properties of artichoke dietary fiber, with the latter one being more effective. This study would provide new ideas for the comprehensive utilization of artichoke dietary fiber in the future.

In recent years, photocured ceramics has become one of the rapidly developing additive manufacturing technologies. Bioceramics have a promising future in tissue engineering due to their good cellular compatibility, however, a single bioceramic material is difficult to take into account both mechanical properties and biocompatibility, so the application and promotion are greatly limited. In this paper, the modification and design methods of bioceramic materials suitable for photocuring were reviewed. The comprehensive effects of material modification, surface modification, structural design and microstructural regulation on the biological properties such as bone conduction, bone induction, antibacterial, angiogenesis promotion and other biological properties as well as and basic mechanical properties of were discussed. It was pointed out that the function of photocurable bioceramics can be fully realized and its further application can be promoted through the combination of modification and regulation methods, and the realization and interaction mechanism of multifunction should be explored.

The antimicrobial agent 3-(acrylamidopropyl)trimethylammonium chloride (APTAC) was grafted onto vacuum plasma‒treated denim fabrics. Optimal treatment conditions, including sputter-gas species, gas pressure, power, and duration were investigated using Orthogonal Array Testing Strategy (OATS) analysis. The obtained denim fabrics were characterized using energy dispersive X-ray (EDS)，Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). Strength, tactile quality, air permeability, and antibacterial properties of the denim fabric before and after grafting were characterized. The results showed that APTAC was successfully grafted onto the denim fabric under conditions using an argon/oxygen mixture as sputtering gas, a sputtering flow ratio of 50:50, a vacuum plasma discharge power of 500 W, and a treatment time of 5 min without affecting the fabric’s air permeability or mechanical properties. Antibacterial efficacy tests showed that APTAC-treated cotton fabric inactivated 92.8% of S. aureus and 94.87% of E. coli O157:H7 in 30 min contact time, thereby achieving sound antimicrobial activity.

ObjectiveThe purpose of this study is to explore the mechanism of electroacupuncture at Baihui and Shenting acupoints to alleviate cerebral ischemia-reperfusion injury by regulating BNIP3L-mediated mitophagy.MethodsA total of 60 SD rats were randomly divided into sham operation group (n=15) and operation group (n=45) by using the random number table method. Only the blood vessels were separated and exposed in the sham operation group, without ligation and no nylon thread inserted. The rats in the operation group were treated with the middle cerebral artery occlusion (MCAO) method to prepare the focal cerebral ischemia-reperfusion (I/R) model, and the Zea Longa method was used to score the neurological function 2h after the operation. Finally, 30 rats were included in the operation group. The included operation group rats were further randomly divided into the model group, electroacupuncture group, and electroacupuncture+3-MA group, with 10 rats in each group. After grouping, each group was treated with different methods such as electroacupuncture for 7 days, and the Zea Longa method was used to evaluate the neurological function again on the 1, 3, 5, and 7 days. After 7 days of intervention, the left cerebral cortex tissue of each group was obtained, hematoxylin-eosin (HE) staining was used to observe the pathological changes of the brain tissue, the expression level of LC3-Ⅱ/LC3-Ⅰ protein was detected by Western blot, and the tissue immunofluorescence technology was applied to detect the expression and colocalization of mitophagy-related protein BNIP3L and SQSTM1 labeled. The TUNEL method detected the apoptosis rate of rat nerve cells in each group.Results1) The neurological scores of the rats in the operation group were significantly increased 2 hours after the MCAO, and the rats in the sham-operation group did not show symptoms of neurological deficit. On the 7th day after the intervention, the neurological scores of the rats in the model group and the electroacupuncture+3-MA group still increased significantly, which were significantly different from those in the sham operation group (PPPPPP

Objective To analyze the expression of KCNJ11 mRNA in gliomas and its prognostic value. Methods The clinical, histopathological and molecular pathological features of 273 patients with gliomas were collected from CGGA. We analyzed the differences of KCNJ11 mRNA expression in different types of gliomas and the survival time of patients with high and low expression of KCNJ11 mRNA in different subtypes of gliomas. Results The expression levels of KCNJ11 mRNA in young glioma and primary glioma patients were higher than those in old glioma and recurrent glioma patients, respectively (P=0.008, 0.001). The expression of KCNJ11 mRNA in oligodendroglioma was the highest, astrocytoma was the second, and glioblastoma was the lowest (P=0.000). The expression of KCNJ11 mRNA in WHOⅡ grade glioma was the highest, WHOⅢ was the second, and WHOⅣ was the lowest (P=0.000). The expression levels of KCNJ11 mRNA in IDH-mutant type glioma patients were higher than those in IDH-wild type glioma patients (P=0.000). The expression of KCNJ11 mRNA in deletion of 1p/19q glioma patients was higher than that in non-deletion of 1p/19q ones (P=0.000). The expression of KCNJ11 mRNA in MGMT methylated glioma patients was higher than that in non-methylated ones (P=0.036). The survival time of patients with high expression of KCNJ11 mRNA (≥2.77) was longer than that with low expression (P=0.000). Multivariate Cox analysis showed that the high expression of KCNJ11 mRNA was an independent factor affecting the good prognosis of patients with glioma. Conclusion The expression of KCNJ11 mRNA is negatively related to the malignant degree of the tumor. The high expression of KCNJ11 mRNA is an independent factor affecting the good prognosis of patients with glioma.

Objective To investigate the effect of integrated traditional Chinese and western medicine nursing in rehabilitation of patients with hemiplegic patients after ischemic stroke. Methods A total of 126 patients with hemiplegia after ischemic stroke were selected. According to the method of random number table, they were divided into control group and observation group, with 63 cases in each group. All patients received conventional drug treatment, routine care and rehabilitation training, and those in the observation group were given integrated traditional Chinese and western medicine nursing interventions. The Fugl-Meyer Assessment (FMA) scale and Brathel Index were measured and compared between two groups. The effect of rehabilitation nursing was evaluated by self-made rating scale. Results The scores of FMA and BI increased in both two groups after intervention, and scores of FMA and BI in the observation group were higher than those in the control group (P＜0. 01). The score for effect evaluation of nursing intervention in the observation group was higher than that in the control group (P＜0. 01). Conclusion In the early rehabilitation of hemiplegic patients after ischemic stroke, the use of integrated traditional Chinese and Western medicine nursing can improve the recovery and quality of life of patients. (目的 观察中西医结合护理干预在缺血性脑卒中偏瘫患者康复中的应用的效果。方法 选取126例缺血性脑卒中偏瘫患者为研究对象, 按照随机数字表分为对照组和观察组, 各63例。2组均接受药物治疗, 对照组接受常规护理和康复训练指导, 观察组在对照组的基础上实施早期中西医结合护理干预。对比干预前和干预后2组Fugl-Meyer运动功能量表(FMA)评分和Barthel指数(BI)评定结果, 评价护理效果。结果 干预后, 2组FMA量表评分和BI评分均较干预前上升, 且观察组FMA量表评分和BI评分高于对照组, 差异有统计学意义(P＜0. 01)。观察组护理效果评价得分高于对照组, 差异有统计学意义(P＜0. 01)。结论 缺血性脑卒中偏瘫患者早期康复中实施中西医结合护理干预, 可以促进患者运动功能康复, 提高患者生活质量。)

Sleep disorder is a severe and frequent complication in patients after stroke. It is characterized by the high morbidity, poor prognosis and reduced quality of life. The Traditional Chinese Medicine (TCM )extended care has unique advantages in preventing sleep disorders after stroke. This paper summarized the research status of sleep disorder after stroke in perspectives of TCM theory application, TCM preventive treatment and TCM extended care technology, and put forward some thoughts to provide reference for research and clinical nursing practice in the future. (睡眠障碍是脑卒中常见并发症之一, 发病率较高, 且会加重病情, 影响预后, 降低患者生活质量。中医延续性医疗护理在预防中风后睡眠障碍方面具有独特优势。本文综述了脑卒中后睡眠障碍中医理论应用、中医预防和中医延续性医疗护理技术的研究现状, 并提出一些思考, 以期为后续研究和临床护理工作提供参考。)

ObjectiveTo analyze the drop-out rate of participants in antidepressant clinical trials and to explore the related influencing factors.MethodsA retrospective analysis was carried out on the participants of 9 antidepressant clinical trials conducted at the Affiliated Brain Hospital of Guangzhou Medical University from 2013 to 2020. A self-compiled questionnaire was used to collect the subjects' demographic data， disease characteristics and the final completion of the trial， thereafter， the participant drop-out rate and related influencing factors were discussed.ResultsA total of 157 cases were enrolled， including 120 cases completed and 37 cases dropped out the trail. The causes of drop-out were poor efficacy in 13 cases （35.14%）， presence of adverse reactions in 12 cases （32.43%）， withdrawal of informed consent in 8 cases （21.62%） and loss of follow-up in 4 cases （10.81%）. Correlation analysis showed that participant drop-out was positively correlated with the level of anxiety （r=0.224， P

Advanced deep hole grouting reinforcement technology is proposed. The effects of VAE emulsion on cement-based materials were studied. The effects of VAE emulsion on the bonding strength between cement based materials and coal and the compressive strength of cement based materials were studied by axial tensile test and cube compression test. The microstructure characteristics of VAE modified cementitious materials and coal interface transition zone were analyzed by scanning electron microscopy. The results showed that the water cement ratio of composite grout showed a trend of first decrease and then increase with the increase of aggregate cement ratio. VAE emulsion increased the interfacial bond strength between slurry and coal and the compressive strength of slurry consolidated coal block. The porosity of cement slurry decreased with the addition of VAE emulsion, and the compactness of the effective layer structure was enhanced. The VAE emulsion diffused into the ordinary cement paste to form a polymer film “tie” structure, which improved the composition structure of the cement based material and coal interface, thus enhancing the bond strength between the cement based material and the coal body.

Objective To investigate the effect of Sanyrene combined with Mepilex Border in prevention of pressure injuries in the perioperative period of the spinal surgery. Methods Totally 150 patients undergoing thoracolumbar surgery in prone position were randomly divided into the observation group and control group, with 75 cases in each group. In the control group, the Mepilex Border dressing was used to prevent pressure injuries in the perioperative period. In the observation group, Sanyrene cream was smeared at high-risk areas of developing pressure injuries such as forehead, zygoma, lower jaw, anterior superior spine and knee, followed by the external use of Mepilex Border dressing. The incidence of pressure injuries in two groups was compared. Results The incidence of pressure injuries in the observation group was lower than that in the control group (P＜0. 05). Conclusion Sanyrene combined with Mepilex Border is potentially effective to prevent the pressure injuries in the perioperative period of the spinal surgery. (目的 探讨赛肤润联合美皮康预防脊柱手术围术期压力性损伤的效果。方法 俯卧位胸腰椎手术患者150例按照随机数字表分为观察组和对照组, 每组75例。观察组在摆放手术体位前使用赛肤润涂抹在易发生压力性损伤的前额、颧弓、下颌、髂前上棘、双膝关节等骨隆突出处, 涂抹2 min后贴上美皮康, 对照组仅采用美皮康进行干预。比较2组患者围术期压力性损伤发生情况。结果 观察组围术期压力性损伤的发生率低于对照组, 差异有统计学意义(P＜0. 05)。结论 赛肤润联合美皮康可有效减少脊柱胸腰椎手术中压力性损伤的发生。)

Objective To investigate the correlation between discharge readiness and uncertainty in illness among parents with preterm infants hospitalized in NICU, so as to provide a reference for clinical training. Methods Totally 75 parents with preterm infants were investigated using Readiness for Hospital Discharge Scale-Parent Form (RHDS-FM) and Parents’ Perception of Uncertainty Scale-Family Member(PPUS-FM). Results The total score of uncertainty in illness and discharge readiness were (95. 73±13. 49) and (132. 04±25. 85) respectively, 54. 67%(41/75) of the parents believed that they were not ready for discharge; and the discharge readiness was negatively correlated with the uncertainty of illness (r= -0. 346, P

The construction vehicles runs and works on the off-road for a long time， and it is easy to produce violent vibration in many directions. To solve this problem， a 3-RPS parallel seat mechanism is proposed based on the comparative analysis of multiple parallel mechanisms. The single-open-chain theory and UG simulation are used to verify its "one flat and two turns" motion state. And the D-H matrix is used to analyze the positive pose model of seat mechanism motion. The seat mechanism model is established in Adams software， and the vibration damping performance of the seat model is simulated and analyzed for four different installation positions because of considering the different installation positions of the branch chain will produce different vibration damping effects. The research shows that the seat mechanism has good vibration damping performance. Branch chain is installed on the axis， the direction of vibration reduction effect is superior to the other position， and 120° three branches chain installed uniform damping effect is better than other ways. The results of this study can provide reference for the installation of parallel seats in construction vehicles under different working environments. At the same time， it is of great significance to improve the comfort and safety of construction vehicles.

Objective To investigate the role of trichostatin A (TSA) and its mechanism on secretory function of peripheral lymph node cells in mice. Methods The adult male C57BL/6 mice were sacrificed and their peripheral lymph nodes (LN), mesenteric lymph nodes (MLN), Peyer's patches (PP), spleen (SP), bone marrow (BM) and thymus (Thy) were collected. The mRNA levels of musculin (MSC), interleukin-17 A (IL-17A) and interleukin-22 (IL-22) in above immune organs were detected by real-time quantity polymerase chain reaction (qPCR). Then the cell suspensions with high mRNA levels of MSC, IL-17A and IL-22, were prepared and randomly divided into 6 groups, including control group, 1 μg/mL lipopolysaccharide (LPS) group, 1 μg/mL LPS+10 ng/mL TSA group, 1 μg/mL LPS +30 ng/mL TSA group and 1 μg/mL LPS + 50 ng/mL TSA group. After the above cells were cultured under 37 ℃ and 5% CO2 for 6, 12 or 24 h, the supernatant and cells were collected. The secretion levels of tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) from the supernatant were measured by enzyme linked immunosorbent assay (ELISA), while the optimal time point of TSA treatment was determined. And then, the mRNA levels of MSC, IL-17A and IL-22 were detected by qPCR at this time point. Results Our results suggested that the mouse LN had highly expressed MSC, IL-17A, and IL-22 when compared with BM (P < 0.01, P < 0.05), and similar results were seen when compared with Thy (P < 0.05). Compared with the LPS group, different concentrations of TSA decreased the secretion levels of TNF-α and IL-10 (P < 0.01, P < 0.05), and at the same time, the treatment down-regulated the expression levels of IL-17A and IL-22 (P < 0.01), while up-regulated that of MSC (P < 0.01, P < 0.05). The best time point was identified as 12 h. Conclusion TSA inhibits the secretory function of LN cells stimulated by LPS, which might be related with the changes of MSC, IL-17A and IL-22 expression

BACKGROUND The main types of primary tin ore occur in skarn, porphyry, cassiterite silicate vein, cassiterite sulfide vein, quartz vein and greisen tin deposits. Tin ores are generally insoluble in hydrochloric acid, nitric acid and aqua regia, and tin ores cannot be dissolved completely when treated with sulfuric acid or hydrofluoric acid. Traditional measurement methods such as phenylfluorone-cetyltrimethyl ammonium bromide spectrophotometry and iodometry have disadvantages, such as the serious interference of the associated elements in the sample, poor stability, high detection limit and low analysis efficiency. OBJECTIVES To establish a method for the determination of tin in primary ore by Inductively Coupled Plasma-Mass Spectrometry. METHODS The sample was melted and decomposed by sodium oxide, and leached by hot water, followed by tartaric acid and hydrochloric acid acidification. 103Rh was used as the internal standard element to correct instrument signal drift, and the matrix effect was overcome by high-dilution factors. RESULTS The detection limit of the method was 0.1μg/g for tin, the precision was less than 5%, the minimum detection concentration was 0.4μg/g, and the measurement range was 12.5-12700μg/g. CONCLUSIONS The method has simple pretreatment and operation. The analysis efficiency and data quality are an improvement over traditional methods.

The tooth surface of the spur face gear is a kind of complex space curved surface, in order to realize the batch machining of complex space curved surface products with difficult cutting materials, the main technology of electrolytic machining is mainly used at present. Considering that electrolytic machining has some problems such as low efficiency of cathode design and difficult to guarantee the design accuracy in the machining of complex dissimilar surface products, an intelligent design method of cathode profile based on the characteristics of standard cathode is presented. Firstly, based on complex tooth surface grid planning principle, the coordinate of each sampling tooth surface is calculated by section lofting method. Secondly, by analyzing the curvature radius of each tooth surface sampling point, the design scheme of the corresponding cathode tool profile is constructed based on the theory of electrolytic machining equilibrium gap theory. Finally, using the GUI human-computer interface in Matlab, the intelligent cathode profile design system for spur face gear is constructed. Meanwhile the experimental shows that the machining accuracy of the cathode surface designed by the system is up to IT8.

Aiming at the working process of the press crimping device for paper tape crimping machine，on the basis of analyzing the movement process of the swing roller， the swing roller is regarded as the follower of cam mechanism. Its rotation angle is defined as equivalent to the stroke of the follower， and the action electronic cam curve of the swing roller is constructed. Thus， the control of the swing roller can be realized based on the electronic cam control mechanism. The definition of the electronic cam curve， especially the curve forms in the acceleration and deceleration area， and the angle relationship between the swing roller and the driving shaft in the acceleration and deceleration area are discussed in detail. It is concluded that the rotation angle of the driving shaft is twice as much as the rotation angle of the swing roller in the acceleration and deceleration area. Taking this as a guide， the parameters setting of the electronic cam function of servo motor are discussed， and it can be set off-line at different speeds of paper tape. Finally， the design idea of the PLC program to realize the above control is discussed and applied to the actual system. The reliability and stability of the press crimping device have achieved the desired effect.

Objective To investigate the clinical efficacy and safety of Kang'ai injection combined with Oxaliplatin, Fluorouracil and Leucovorin (OFL regimen) in the treatment of patient with gastric cancer. Methods A multi-center randomized controlled study was conducted on 300 patients with gastric cancer treated in five hospitals from March 2012 to June 2015. The patients were randomly divided into control group and experimental group. The control group were treated with OFL regimen. The experimental group were treated with Kang'ai injection on the basis of the treatment of control group. The short- and long-term clinical efficacy after treatment and adverse reactions during the treatment were observed and compared between the two groups. Results (1) The short-term clinical efficacy of the experimental group was significantly higher than that in the control group (35.62% vs. 22.86%, P < 0.05); (2) The quality of life of patients in the experimental group after the treatment was significantly better than that in the control group(P < 0.05); (3) The PFS was not significantly different between the control group and the experimental group (25.89 vs. 26.35 months, P > 0.05), there was no significant difference in the 3-year survival rate between the two groups (P > 0.05); (4) The incidence of neurotoxicity and gastrointestinal adverse reaction and thrombocytopenia in the experimental group were significantly lower than those in the control group (P < 0.05). Conclusion Kang'ai injection combined with OFL regimen could significantly improve the short-term clinical curative effect and reduce toxic and side effects of chemotherapy in patients with gastric cancer.

As the first ecological demonstration province in China, Hainan province follows the principle of "building an ecological province" routinely. In order to further promote the construction of ecological civilization and protect the river ecology in Hainan, it is of great theoretical significance to carry out the research on the ecological water requirement of the three largest rivers in Hainan province. Based on the long sequence data of monthly flow obtained by the seven main hydrologic stations of three largest rivers,this paper calculates the ecological flow by the methods of monthly minimum mean flow, 7Q10, monthly minimum ecological runoff computation and monthly frequency computation respectively. After analyzing, comparing, and testing by the Tennant method, it is showed that the result obtained by monthly minimum ecological runoff computation method and monthly frequency computation method meets the requirement of minimum ecological flow and appropriate ecological flow respectively. Thus, the minimum ecological water requirement and the appropriate ecological water requirement of the three largest rivers can be calculated, which can provide scientific basis for the optimal allocation and scheduling of water resources in the river basin.

Objective To explore the relationship between chromosome 1p/19q codeletion and MGMT promoter methylation in oligodendrogliomas. Methods We collected 35 cases of oligodendroglioma and 32 cases of anaplastic oligodendroglioma tissue specimens as the experimental group, and 20 cases of astrocytomas and 20 cases of normal brain tissue specimens as the control group. Fluorescence in situ hybridization (FISH) was used to detect the chromosome 1p/19q codeletion, and the methylation status of MGMT promoter was analyzed by methylation-specific PCR (MSP). Results The frequencies of the 1p/19q codeletion in oligodendrogliomas and anaplastic oligodendrogliomas were 85.71% and 75% respectively, which were significantly higher than those in astrocytomas and normal brain tissues(P < 0.05). The frequencies of the MGMT promoter methylation in oligodendrogliomas, anaplastic oligodendrogliomas and astrocytomas were significantly higher than those in normal brain tissues(P < 0.05), but there was no statistical difference among each other(P > 0.05). The Spearman correlation analysis showed that the 1p/19q codeletion was positively correlated with the MGMT promoter methylation in oligodendrogliomas. Both 1p/19q codeletion and MGMT promoter methylation were correlated with the 3-year survival rate(P < 0.05). Conclusion 1p/19q codeletion is closely linked with MGMT promoter methylation in oligodendrogliomas, therefore, the combined detection of these two biomarkers may be helpful for diagnosis and evaluating the prognosis.

The geochemical characteristics of the rare earth element contents in Yimin lignite were analyzed by using ICP-MS and conventional chemical analysis methods. The results show that the rare earth element in Yimin lignite mainly occurs in clay minerals and titanium-containing minerals, and less being in pyrite, carbonates, sulfates, which result in dilution effect. Meanwhile, a complementary relationship on the occurrence of the rare earth dements in humic acid extracted from demineralized coal and residue was found. The relative enrichment degree of rare earth elements in the humic acid extracted from demineralized coal is light rare earth element (LREE) < medium rare earth element (MREE) MREE > HREE, which suggest that the distribution of rare earth elements in the organic matter is characterized by HREE mainly occurs in humic acid while LREE are in the major organic structure of coal. [ABSTRACT FROM AUTHOR]

The degeneration of karst ecosystem is closely associated with the reduction of soil nutrients and fine root biomass, and the retention of soil nutrients is of significance in sustaining ecosystem functioning. To understand the changes in the fine root biomass and soil nutrient retention in degenerated karst ecosystems, a comparative study was conducted with three typical vegetation stands (forest, shrub, and shrub-grass) in Central Guizhou of Southwest China. Soil samples with fine roots were collected from the depths 0-5 cm, 5-10 cm, and 10-15 cm, with the related indices of fine roots and nutrients measured. In the three stands, fine roots dominantly distributed in 0 -10 cm soil layer, and decreased sharply with soil depth. The living fine root biomass in 0-10 cm soil layer under forest, shrub, and shrub-grass occupied 83. 36% , 86. 91% , and 93. 79% of the total fine root biomass, and 42. 78% , 56. 75% , and 53. 38% of the total living fine root biomass within the 0-15 cm soil layer, respectively. The fine root biomass of predominant plant species varied with vegetation types. The N and P storage of the living fine roots in 0-5 cm soil layer under forest stand was significantly higher than those under shrub stand and shrub-grass stand, and no significant differences were observed between the latter two stands. However, the N and P storage of the living fine roots in 5-10 cm soil layer under different stands decreased in the order of forest > shrub > shrub-grass (P<0. 05). There was a significant positive correlation between the plant aboveground biomass and the living fine root biomass in 0-10 cm soil layer, and a significant negative correlation between the N and P contents of plant leaves and the specific length of living fine roots, illustrating that the nutrient uptake and retention by the living fine roots could have particular importance in the aboveground biomass establishment and ecosystem functioning. [ABSTRACT FROM AUTHOR]

The article reports on the veterinary study of Huang Xiao-yan and colleagues which compared the adjuvanticity of sulfated astragalus polysaccharides. It states that the chicken were vaccinated and blood sampled by cardiopuncture to determine the peripheral T lymphocyte proliferation. The results indicate that the modified sAPSs could enhance antibody titer and promote lymphocyte proliferation which can pass as a new immunopotentiator.

Based on analysis of technical advantages of gob-side entry retaining by cutting roof to release pressure, combined with geological and mining technical conditions of 19022 working face of Shiquan Coal Mine, the scheme of gob-side entry retaining by cutting roof to release pressure for Shiquan Coal Mine was proposed: high-strength anchor with single hydraulic props were selected for advanced reinforcement support of mining roadway; pre-split blasting was carried out on the roof of roadway from goaf to advanced support section to form fracture top cutting line during pressure relief; reinforcement support in the back of the working face adopted the form of sluice column + single hydraulic props lifting shed + hydraulic lifting shed. The results of mine pressure monitoring show that the average subsidence of roadway roof is 95 mm, and the average displacement of the two gangs is 225 mm, which is in line with the deformation requirements of the roadway section;the average support resistance of the roadway supports is 33 MPa, which meets the requirements of roadway support strength.

The future broadband wireless communication network will be a heterogeneous network with multiple access technologies seamlessly integrated. In such heterogeneous network, the key issues are how to share resources such as frequency, software, hardware and so on among different types of networks to reduce cost as well as to provide better services to users. Therefore, a heterogeneous network resource convergence platform was proposed based on the centralized radio access network architecture. This platform provides a feasible solution to support resource cooperation among different networks. Moreover, the key technologies were illustrated in detail, such as resource virtualization, processing resource allocation, dynamic frequency share, network coverage optimization, system performance analysis, etc.

The paper proposed a control scheme of three-level active power filter based on ip-iq harmonic current detection, fuzzy PI current control and space vector pulse width modulation. It established a mathematical model of the three-level active power filter, and introduced concrete realization of control method of DC-side voltage stabilization and neutral-point potential balancing of the three-level active power filter. The simulation and experimental results show that the three-level active power filter controlled by the scheme has good effect of harmonic compensation, and can stabilize DC-side voltage and capacitance neutral-point potential well.

Objective To investigate current status and safety about off⁃label use of levetiracetam, topiramate, oxcarbazepine, lamotrigine among pediatric patients in Sichuan area, so as to provide baseline data for formulating guidelines of off ⁃ label drug use. Methods Medical records of pediatric epileptic patients receiving antiepileptic drugs (AEDs) from July 2010 to November 2011 were collected at the following hospitals: West China Second University Hospital of Sichuan University, Chengdu Women's and Children's Central Hospital and Sichuan Provincial People's Hospital. The numbers of patients receiving AEDs and novel AEDs were calculated. Off⁃label drug use and the category of off⁃label drug use were judged according to the indications listed in drug instructions. The incidence of off⁃label drug use was calculated. The patients receiving novel AEDs were devided into on⁃label and off⁃label use groups; the clinical characteristics of these two groups were summarized and adverse reactions of two groups were compared by using χ2 test. Results During the study period, there were totally 854 patients receiving AEDs including 670 patients receiving novel AEDs. Among 670 patients 406 patients off⁃label use group received off⁃label use of novel AEDs, accounting for 47.54% (406/854) of the total patients receiving AEDs and 60.60% (406/670) of patients receiving novel AEDs. When compared with on⁃label use group, off⁃ label use group had more younger patients, more patients with single ⁃ drug use and more patients with generalized epilepsy or epileptic syndrome. The rates of off⁃label using drug were levetiracetam 78.50% (157/200), topiramate 79.81% (253/317), oxcarbazepine 21.32% (42/197) and lamotrigine 33.33% (21/63). The off⁃label use of levetiracetam and topiramate occured in all three aspects: age, single⁃drug use and seizure type. The adverse reaction rates of off⁃label use were oxcarbazepine 16.67% (7/42), topiramate 14.81% (36/243), levetiracetam 10.60% (16/151), lamotrigine 9.52% (2/21). When compared with the adverse reaction rates of on⁃label use group, the difference was not statistically significant (the values of χ2 were 0.375, 0.448, 0.014, 0.109 respectively and the values of P were 0.540, 0.503, 0.906, 0.742 respectively). Conclusion Among pediatric patients in Sichuan area, the rate of off⁃label use of novel AEDs was very high, especially for topiramate and levetiracetam. The follow ⁃ up data of this survey suggested that off⁃label use of novel AEDs with careful observation for adverse reactions had good safety and tolerance. DOI：10.3969/j.issn.1672⁃6731.2012.05.008