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After over 60 years of development, the space propulsion field in China has made tremendous progress in terms of technology system and product pedigree, and has supported major engineering applications including manned spaceflight, applied satellites, and deep space exploration. However, considering the requirements of future major aerospace missions in China, the technical level of current space propulsion systems is still insufficient, and it is urgent to plan directions for the innovative development and breakthroughs of the field. This study reviews the development status of the space propulsion systems from the aspects of electric, chemical, nuclear, and new-concept space propulsion, and analyzes the requirements of future applications. Specifically, high-performance, low-cost space propulsion systems are required to support the networking of low-Earth-orbit (LEO) small satellites; high-thrust, reusable low-temperature chemical propulsion technologies are required for new space-transportation systems; and multi-type, long-life space propulsion technologies are required for deep-space applications. The results demonstrate that the space propulsion field in China still faces multiple challenges. First, the system reliability and lifespan require further improvement. Second, the space propulsion systems of China still lag behind the advanced international level in terms of product maturity of some technologies. Third, this field typically has a high product cost. Fourth, there are few types of optional technologies, and the research progress of key technologies is lagging. Therefore, we propose the following suggestions: (1) optimizing technology options through top-level planning, (2) improving the development mechanism of the field by emphasizing basic research, and (3) clarifying and promoting scientific research and development in key technological directions, thereby achieving in-orbit applications of the propulsion systems for LEO small satellites, Earth–Moon space transfer, and deep space exploration (including manned spaceflight).

The combination method of numerical simulation and experimental verification was used to optimize the current evaluation method of tear strength of rubber unnicked angle test piece. Firstly, the tear energy at angle position of rubber test piece with different clamp distances was simulated by the simulation software, and then advanced video extensometer-digital image correlation analysis software was used to obtain the strain distribution cloud nephograms and the multi-location strain curves of the test piece with time. A new method was proposed to evaluate comprehensively the unnicked angle tear property by combining strain distribution cloud nephogram and corrected tear strength, and the method applicability was verified by the tear strength test of pure natural rubber and natural rubber/synthetic rubber blends. The results showed that the tensile degree of the non-effective test region and the tear energy at angle position were all different with the different clamp distances, when the other para-meters of the test piece were the same, which increased the volatility of the test results. Compared with the standard currently in effect, the variation coefficient of parallel test results could be reduced by using the corrected tear strength, and the test results was positively correlated with the carbon black dispersion in the vulcanizates.

Granary is an important facility to ensure the safety of grain storage. The granary is a large closed space with dim lighting and poor air circulation. Operations such as fumigation and air conditioning increase personnel safety risks. The identification and analysis of abnormal behaviors of workers through security videos in the granary has become a key safe operations for workers as an important technical guarantee. This paper proposed a video recognition algorithm for abnormal behavior of workers in a granary based on a skeleton sequence multi-algorithm. First, the YOLOv3tiny model was used to quickly detect the human body, combined with Sort to track the motion trajectories of multiple targets, and the human skeleton coordinate sequence and weight information were extracted through the AlphaPose model. Then, based on the real spacial graph (RSG) composed of natural connection nodes of the human skeleton and virtual spacial graph (VSG) constructed by interconnecting the center of gravity of the virtual human body with the head, hands, and feet, the bin was extracted based on the balance of the interaction between the center of gravity of the human body dynamics and the hands and feet. Spatial characteristics of abnormal behavior of internal workers and spatiotemporal characteristics of concatenated temporal convolution (TC). Finally, a virtual-real combining spatial temporal graph convolution network (VR-STGCN) video recognition algorithm for abnormal behavior of granary workers was proposed. At the same time, a hybrid dataset was built, and comparative experiments and analysis were conducted between VR-STGCN and four algorithms such as SSD, PCANet, Two-StreamCNN, and STGCN. The results showed that all indicators of VR-STGCN were better than those of the other four algorithms. VR-STGCN can accurately identify abnormal behaviors such as falling, crawling, and lying down of people in the granary in complex environments such as insufficient light, multiple targets, and long distances. The recognition accuracy reached 97.7%, and the processing speed was 18.67fps, which can analyze the abnormal behavior of workers in real time. The research results could provide a new and efficient technology for the safety of granary workers in complex environments.

In the process of vegetable fermentation, the variety and quantity of microorganisms are complex and changeable. Lactic acid bacteria (LAB), as the main power in the process of vegetable fermentation, participate in the regulation of various metabolic pathways and affect the formation of flavor. In this review, the changes of major flavor metabolites during vegetable fermentation and their internal relationship with the community structure and abundance of LAB were summarized, then the potential mechanism of LAB fermentation to produce flavor substances was discussed. Moreover, the application of LAB in vegetable fermentation was prospected.

Objective To explore the related risk factors of death in patients with severe trauma, and to establish a preliminary early warning scoring system for the prognosis of severe trauma (hereinafter referred to as the prediction model), so as to provide convenience for clinicians to judge the prognosis of patients early, timely and accurately. Methods The clinical data of 307 patients with severe trauma treated in the Emergency Department of the First Affiliated Hospital of Army Medical University from January 2019 to June 2021 were collected and retrospectively analyzed. They were divided into survival group (n=262) and death group (n=45) according to the outcomes. The age, sex, comorbidity, injury mechanism, number of injury sites, vital signs at admission, results of blood routine test, blood biochemistry test and blood coagulation test, blood gas analysis, endotracheal intubation at admission, emergency operation, use of vasoactive drugs and Glasgow coma score (GCS), injury severity score (ISS), and new injury severity score (NISS) were compared between the 2 groups with univariate analysis. The statistically significant indexes in univariate analysis were included in multivariate logistic regression analysis, and the risk factors affecting the prognosis of the patients were screened, and the prediction model was established according to the assignment of regression coefficient β, and receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of the prediction model for the prognosis of patients with severe trauma. Results There were differences in injury mechanism, number of injury sites, comorbidity, endotracheal intubation on admission and use of vasoactive drugs between the 2 groups. The age, serum sodium, serum creatinine (Scr), lactic acid, blood glucose, fibrin degradation products and D-dimer were higher, while the body temperature, blood potassium, activated partial thrombin time, oxygenation index and GCS were lower in the death group than the survival group. The results of multivariate logistic regression analysis showed that age (≥62.5 years), Scr (≥77.37 mmol/L), GCS (≤12.5), oxygenation index (≤253.5 mmHg) and body temperature (≤36.25 ℃) were independent risk factors for death in the patients with severe trauma (P < 0.05). The above 5 variables were scored to form the prediction model, which divided severe trauma patients into low-risk, medium-risk and high-risk, and the incidence of death was 2.2%, 28.2% and 74.4%, respectively. When the cut-off value of the prediction model was 15.5, the sensitivity was 86.7%, the specificity was 89.4%, and the Yoden index was 0.764. Conclusion The prediction model is composed of age, Scr, GCS, oxygenation index and body temperature. Its predictive effect is better than those of the 5 indicators alone, and has more advantages than ISS, NISS, acute physiology and chronic health evaluation Ⅱ, sequential organ failure assessment and modified early warning score. It is more helpful to evaluate the prognosis of patients with severe trauma quickly and accurately.

Objective To investigate the differences of peripheral blood DNA methylation in identical twin adolescents with different depressive phenotypes and explore whether these differentially expressed genes can be used as candidate genes involved in the occurrence of depression. Methods Three pairs of verified identical twin adolescents (12~18 years old) were recruited in this study. Phenotypic differences of depression between the twins were determined by Beck Depression Inventory-Ⅱ (BDI-Ⅱ) scores and emotional factor scores of Strength and Difficulty Questionnaire (SDQ) for students. After Infinium MethylationEPIC BeadChip Kit was used to interrogate over 850k methylation sites, those with P < 0.05 and the absolute value difference of methylation β value greater than 0.1 (|△β| >0.1) were selected as the differential methylation sites. Gene Ontology (GO) functional annotation analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, as well as protein-protein interaction (PPI) network were performed to identify important genes associated with major depressive disorder (MDD) and their methylation changes. Results Three pairs of identical twin adolescents with different depressive phenotypes were divided into depressive phenotype group and normal phenotype group. A total of 57 genes with different methylation levels were screened between the 2 groups, including 45 genes with increased and 12 genes with decreased DNA methylation levels. GO analysis showed that differential genes were most significantly enriched in biological processes such as central nervous system development and regulation of RNA metabolic process. KEGG analysis indicated that differential genes were significantly enriched in synaptic long-term depression (LTD), PI3K-Akt signaling pathway and TNF signaling pathway. Besides, direct or indirect interactions between RHOA and several differential methylated genes were found in PPI network. Conclusion Changes in DNA methylation levels of CSF1R, NOS1, AHR and other genes in peripheral blood of identical twins with different depressive phenotypes may regulate gene expression through synaptic long-term depression (LTD), PI3C-Akt and other signaling pathways involved in the occurrence of depression.

Objective To investigate the effect of hemeregulated nuclear receptor(Rev-erb) agonist SR9009 on the proliferation and potential mechanism of human colon cancer cell line HCT116. Methods HCT116 cells were cultured and treated with Rev-erb agonist SR9009 with proper dosagee and treatment time. The cell proliferation was observed with a phase contrast microscopve. The cell viability was tested using a CCK-8 kit. The mRNA transcription of Rev-erb α, Rev-erb β and autophagy genes Beclin1, LC3 and p62 were detected by real-time PCR. The protein expression of Rev-erb α, Rev-erb β, Beclin1, LC3 and p62 were detected by Western blot. Results 1)Rev-erb agonist SR9009 inhibited the HCT116 cell proliferation as compared with control group (P＜0.05), and the right dose of SR9009 was 20 μmol/L and the treatment time was 24 hours. 2)SR9009 significantly increased Rev-erb α and Rev-erb β mRNA transcription (P＜0.01) and protein expression (P＜0.05) in HCT116 cells. 3)R9009 significantly reduced the expression of autophagy genes Beclin1 and LC3 in HCT116 cells (P＜0.05), causing autophagy protein p62 accumulation. 4)HCT116 cell viability was further decreased with an autophagy inhibitor 3-methyladenine (3-MA) after SR9009 treatment (P＜0.05), the cell viability was restored by an autophagy activator rapamycin (P＜0.05). Conclusions Rev-erb agonist SR9009 inhibits proliferation and cell viability of colon cancer cell line HCT116 by reducing autophagy.

In recent years, cases of child abuse that result in injuries and death have occurred from time to time in China, and there may be more undetected child abuse cases. However, many pediatricians and forensic doctors lack professional knowledge and formal training in detecting child abuse, which leads to the missed diagnosis, misdiagnosis and misidentification of many cases of child abuse. This paper reviews a large number of relevant domestic and foreign literatures, combined with practical work experience and China’s national conditions, preliminarily summarizes the main points of clinical diagnosis and forensic identification of child abuse cases, in order to provide some help for early detection, accurate identification of child abuse cases and timely and effective treatment and protection for abused children.

Objective According to the guidance for the pilot standardized training system for specialized physicians issued by the National Health and Family Planning Commission (NHFPC) together with other 7 government sectors,the specialist training is aiming for clinicians with sound clinical skills and corresponding scientific research and education capacity in general medicine as well as the specialized clinical disciplines. Methods Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital enrolled the first and second groups of specialist trainees through national registration system, professional assessment with written examination and panel interview. Results Six students were enrolled in the first two groups. The proportion of out-campus enrollment was 33.3%. The matriculates, with ages between 31 to 38, 66.7% were eight-year program graduates with MD degree, 16.7% had bachelor degree, 16.7% had master degree. One student quitted from the training, with a with drawal rate of 16.7%. Conclusions The standardized training of specialized physicians is aimed at clinicians with different educational levels,clinical qualificationsand their social and family social and family backgroundare also more complicated. In order to make the training more effectively, innovational mechanisms and supporting system are critical.

In the recent years, an increasing number of loess landslides were triggered due to extreme climate. The initiation of loess landslides was related to water, including surface water and groundwater, landform, geologic structure, and other factors. Both surface water and groundwater significantly affect loess landslides. Rainfall and irrigation provide plenty of water to loess, creating surface water and groundwater. Surface water flows on the surface of a loess, infiltrating into loess at the same time. The infiltration of surface water transforms loess from an unsaturated state to a saturated state in the loess plateau. The weight of slope mass increases due to the increase in water content of loess. Therefore, the loess slope mass bears shear force and seepage stress at the same time, and the deformation of loess gradually increases with time. More attention should be paid to seepage stress during the infiltration. The fabric inside loess is damaged because of shear force and seepage stress. The presence of seepage stress makes the failure mode different from the shear mode in loess. Eventually, a loess landslide forms as the deformation exceeds the bearing capacity. In this study, the 4.29 landslide in Heifangtai was selected for the purpose of research. Based on field investigation, 60 undisturbed samples from the backwall of landslide were used to conduct triaxial tests. To simulate the shear behavior of saturated loess under seepage shear, loading rates of 0.5, 0.1, and 0.05 mm·min-1 were used and the effect of loading rate on shear strength was identified. Moreover, water heads of 0, 1, 2, and 5 m were set to study the effect of water head on shear strength with loading rates of 0.1 mm·min-1. The stress-strain curve shows obvious strain hardening under seepage shear. Loading rate slightly affects the stress-strain relationship of loess during the seepage shear. In contrast, an increasing water head rapidly decreases the shear stress of loess. The cohesion of loess decreases by 5.24%-63.35% due to seepage shear. Further, the strength correction formula for a loess under the seepage shear condition is obtained by fitting the existing strength index. Fitting performance is evaluated following the fitting process. An empirical equation could be used in geotechnical engineering when seepage shear is considered.

A method to optimize was proposed by the delay parameter of the pulse position modulated UWB signal in indoor environments.The system designed with the proposed method achieves an improved performance and meeted the FCC emission requirement.In particular,the BER performance is analyzed based on a mathematic model of the UWB signal and the result may provide guidance in practical applications.

This article reviews the main technologies for the combined treatment of volatile organic compounds (VOCs) with biological methods in recent years,including photodegradation-biological combined technology, low-temperature plasma-biological combined technology, adsorption-biological combined technology, chemical oxidation-biological combined technology combustion-biological combination technology and biological combination combination technology, it focuses on the research progress and existing problems of biological combination treatment technology, and points out the development prospects and next research directions of such technologies. [ABSTRACT FROM AUTHOR]

To evaluate the clubroot disease-resistant and agronomic characteristics of 16 rapeseed varieties at Duodao District of Jingmen City, factor analysis was performed in this study. The results showed that two common factors (characteristic root >1), the economic index factor F1 and quality index factor F2, were extracted using factor analysis method. Their cumulative variance contribution rate reached 86.637%, which could fully represent the information of original data. The score trend of rapeseed was basically consistent with planting benefit trend, indicated that evaluatoin results were reliable and valid. Rapeseed varieties 18ZP05, 18Miao-337, 18ZP01 and SHR02 had good performance and higher planting benefit, and could be considered suitable to extend at local area in Jingmen City. [ABSTRACT FROM AUTHOR]

Based on the results of drilling and sampling analysis, the paper summarizes the characteristics of sedimentary facies, sand body development and epigenetic alteration of Upper Cretaceous Sifangtai Formation in Yi'an sag, northern Songliao Basin. The Sifangtai Formation can be divided into upper and lower members, with developed braided river facies sediments and meandering river facies sediments respectively. There are usually 1-2 layers of sand body developed in braided river facies, large in scale, with epigenetic oxidation locally. Through the analysis of uranium source, structure, sand body development and epigenetic transformation characteristics, it is considered that Sifangtai Formation has good conditions necessary for sandstone-type uranium mineralization, with great uranium prospecting potential. [ABSTRACT FROM AUTHOR]

Objective To evaluate the value of Knosp classification and cavernous sinus zoning in the diagnosis of pituitary adenoma invasiveness and the significance of endoscopic transnasal surgery for pituitary adenomas. Methods There were 75 cases with pituitary adenomas of Knosp grade 3-4 (44 cases of Knosp grade 3 and 31 cases of Knosp grade 4) who were performed endoscopic transnasal surgery from July 2015 to June 2017 in our hospital. Based on coronal MRI of sellar region in patients with Knosp 3 pituitary adenomas, the ratio R of distance from the middle point of internal carotid artery (ICA) cavernous sinus segment to the upper part of anterior clinoid process segment and vertical distance from the furthest point of tumor invasion to the line was calculated and analyzed statistically. According to cavernous sinus zoning under endoscope and involvement of medial wall of cavernous sinus, patients with Knosp grade 3 pituitary adenomas were further divided into Knosp grade 3A (invasive and non-invasive) and 3B by invading different cavernous spaces. The total removal rate of tumor was reviewed by MRI in sellar region after operation. Results Among 75 cases, 36 were classified as Knosp grade 3A in 44 cases of Knosp grade 3 pituitary adenomas, including 12 cases of invasive pituitary adenomas (mainly involving posterior superior space of cavernous sinus and affecting oculomotor nerve) and 24 cases of non-invasive pituitary adenomas (the tumor pushed against the medial wall of cavernous sinus, presenting "pseudoinvasion"). The ratio R of invasive pituitary adenomas was significantly smaller than non-invasive pituitary adenomas (1.28 ± 0.18 vs. 1.74 ± 0.27; t = 5.275, P = 0.000). The Knosp grade 3A was divided into 2 groups according to the median value of ratio R: ≤ 1.59 group (17 cases) and > 1.59 group (19 cases). The invasion rate of ratio R ≤ 1.59 group was higher than that of > 1.59 group (12/17 vs. 0/19; Fisher's exact probability, P = 0.000). The total resection rate of 75 cases was 72% (54/75), among which the total resection rate of Knosp grade 3 was 84.09% (37/44), and rate of Knosp grade 4 was 54.84% (17/31). The average follow-up period was (14.84 ± 5.66) months, and no one case relapsed. Conclusions The calculation of ratio R in preoperative coronal MRI helps to evaluate the invasion degree of Knosp grade 3A pituitary adenomas. Combined with artificial division of cavernous sinus, it has guiding significance in endoscopic transnasal surgery for pituitary adenoma removal. [ABSTRACT FROM AUTHOR]

Mammalian oocyte maturation is a complex physiological process regulated by a vast number of factors, which aims to produce a fertilizable oocyte from the oocyte finished already the meiotic division and arrested in the secondary metaphase. The meiotic division arrested in secondary metaphase is mainly dependent on the cytoplasm cAMP at high concentration. Meanwhile, many factors and their signaling pathways, as well as cellular structures, are involved in promoting the meiotic division and oocyte maturation, such as LH, EGF, ERKl/2, p38MAPK, Ca2s and gap junction. Oocyte maturation and its molecular regulation were reviewed, so as to provide useful references for the research and treatment of female infertility and the in vitro maturation. [ABSTRACT FROM AUTHOR]

Exploiting the reciprocity of wireless multipath channel in time division system, this paper extracts the information of channel phase as secret keys to propose a secret key generation and distribution scheme for two-way sparse multipath relay channels. The recovery algorithm based on compressive sensing theory is used for the channel estimation, because the wireless multipath channels are generally sparse. The two-way relay channel can be decomposed into two independent end to end channels by the orthogonal pilots design in the end nodes, and the relay broadcasts the pilots and the XOR of secret keys by using the physical layer network coding. By using our proposed scheme, the secret key generation and distribution can be realized in two slots, thus we can overcome the drawback of the key pre-distribution mechanism and ensure the safety of keys. Theoretical analysis and simulation results show that our proposed scheme can effectively realize the secret key generation and distribution in the two-way sparse multipath relay channel and ensure the security of the physical layer communication. [ABSTRACT FROM AUTHOR]

In this paper, an enhanced physical layer security communication scheme is proposed for the multiple antenna systems. The scheme employing transmit antenna selection and artificial noise, also Alamouti coding, improved diversity gain in legitimate channel with low complexity in the transmitter and receiver, and at the same time efficiently jammed the wiretap channel. Consequently it can increase the system secrecy capacity. We analyze the system secrecy capacity and the impacts of the number of antennas and the power allocation between the information signal and artificial noise. Simulation results demonstrate that the proposed scheme can effectively enhance the physical layer security. [ABSTRACT FROM AUTHOR]

In wireless communication, using physical layer attributes to key encryption is presented to ensure information security. But it exists the problem of inconsistent keys and the key generation rate is not high. This paper proposed a new method based on channel quantized phase with guard-bands. Using the phase properties of uniform distribution, the resulting keys had excellent random characteristics and uniformity of distribution. Using the new method which could establish buffer zone at the boundary, it would delete the receiving data which brought wrong keys and effectively improved the consistency of the generated keys. Simulation results show that this method can improve the key generation rate while ensure the accuracy of the generated key. [ABSTRACT FROM AUTHOR]

Impulse noise is extremely harmful to human health. Hence, great progress has been achieved in active noise control (ANC), but most is about the noise control of Gaussian stable distribution, the non-Gaussian impulse noise control research is stiil in an exploratory stage. In this paper, the trends of impulse noise active noise control algorithms developed at home and abroad are analyzed, active noise control of symmetric ɑ stable (SɑS) distribution impulsive noise is studied. An algorithm based on minimizing the squared sigmoid transformation of error signal is proposed. The convergence condition of this algorithm is also analyzed. It does not need the parameter selection and thresholds estimation. Computer simulations are carried out to validate this algorithm. Simulation results prove the effectiveness of the algorithm. Compared to the previous FXlogLMS algorithm, this algorithm has good convergence and stability. According to the Sigmoid function expression, further experimental statistical analysis about the best match relationship of m-value and the alpha value wiil be the next target. [ABSTRACT FROM AUTHOR]

The article presents a study which investigates the effect of forsythiaside on renal tubular epithelial cells (RTECs) transdifferentiation using reverse transcriptase polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA).

Background During the last 2 decades, more and more functional MRI (fMRI) researches have increasingly focused on both structures and functions of the hippocampal region to discover the relationship between hippocampus and memory. In order to reveal the normative pattern of individual development or aging processes of the hippocampus or further memory-related disease prediction, an investigation on such a brain structure's trajectory across the human lifespan is necessary. Methods Regional volume is the most commonly used variable for the structural change of normal brain. The regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) are the two test-retest reliable metrics for detection of functional changes. We here investigate ReHo, ALFF and fractional ALFF (fALFF) based upon both structural and resting state fMRI of 125 subjects from 7 to 85 years old. Results As results, significant age-related decreases were detected for volumes of bilateral hippocampus (corrected Ps = 0.000). In contrast, ALFF (corrected P = 0.034, β = -0.314), fALFF (corrected P = 0.059, β = -0.687) and ReHo (corrected P = 0.005, β = -0.330) demonstrated a trend of negative linear correlation with age in the left hippocampus. Conclusions Our findings partly reflect the structure-function relationship of the hippocampus during the human lifespan. [ABSTRACT FROM AUTHOR]

The computational complexity of traditional Phase Calibration extraction method based on correlation increased greatly with the increasing of PCAL signals' number. An efficient PCAL signals extraction method based on DFT was proposed. According to the equal frequency interval characteristics of PCAL signals' all of the phases of PCAL signals can be obtained by one time DFT computation. The efficiency of the new method has obvious superiority with the increasing of PCAL numbers. The root mean square error (RMSE) formula of phase estimation was derived among S/Ø (single PCAL signal power to noise power spectral destiny ratio), integration time, PCAL frequency interval, quantization bits, and interference with the same frequency, under Gaussian white noise. The RMSE formula is found to be effective by Monte Carlo simulation. [ABSTRACT FROM AUTHOR]

High data rates and high mobility introduce time and frequency selectivity in wideband wireless communication. We need to estimate the channel state information so that the data through fading channel can be received correctly. Exploiting the sparsity of doubly selective wireless channel in both delay domain and Doppler domain, we study the doubly selective channel estimation based on compressed sensing. In order to overcome the instability of the channel estimation caused by the multipath delay spread and Doppler shift, the channel estimation based on ROMP algorithm is studied in this paper. Theoretical analysis and simulation show that the compressive sensing estimation has better performance but with fewer pilots than conventional least square estimation, furthermore, ROMP has better estimation performance than OMP with higher robustness. [ABSTRACT FROM AUTHOR]

A numerical model to simulate loading process of prestressed concrete (PC) continuous beams and slabs at elevated temperature is presented. It is considered that plane sections before bending remain plane after bending. Based on the thermal-mechanical coupling constitutive models of concrete, reinforcing and prestressing steels, the transient strain, creep strain in concrete at time t + 1 could be calculated by the stress in concrete at the former step. The coupled constitutive model of concrete could be decoupled, and the reinforcing and prestressing steels were calculated by the same way. Therefore, the moment-curvature relationships of PC beams and slabs subjected to fire can be calculated. The moment of flexure, deflection and support displacement of the beams and slabs imposed by curvature and support reaction together was calculated respectively. The support reaction was calculated by the iteration method until the deflection compatibility equation at the support was satisfied, and the deflection of continuous beams and slabs could be obtained. The deflection of PC continuous beams and slabs subjected to fire calculated by the computer program is verified by correlative fire resistance experiments. Through these studies, it is shown that support and span restraint effect has significant influence on the fire resistance of PC continuous beams and slabs. The mid-span deflection in side spans is larger than that in inner spans. [ABSTRACT FROM AUTHOR]

PURPOSE: To investigate the influence of HPVI6 E5 on E6 and E7 gene in human oral immortalized epithelial cells (HIOEC). METHODS: The pLEGFP-E5 was transferred into HIOEC cell; Deletion mutation expression vectors were constructed and transferred into HIOEC; RT-PCR was used to detect the gene expression in HIOEC; The expression of E6 anti E7 mRNA was detected by real time-PCR;Cell proliferation of HIOEC was evaluated by MIT. All statistical analysis was performed by using SPSS 13.0 software package. RESULTS: The deletion mutation expression vector of E5 was successfully constructed and applied for further experiments; E5 and the deletion mutation genes were transferred into HIOEC successfully; HPVI6 E5 promoted cell proliferation of HIOEC and made the increased expression raised of E6 and E7 genes; However, the deletion mutation had no significant effect on HIOEC. CONCLUSIONS: HPVI6 E5 is transferred into HIOEC successfully. E5 may promote cell proliferation and upregulate the mRNA expression of E6 and E7 genes. Supported by Natural Science Foundation of Anhui Province (070413086). [ABSTRACT FROM AUTHOR]

To research the load-bearing capacity, deflection and effective prestress in steel wire of prestressed concrete (PC) slabs after elevated temperature, experiments on mechanical performance of thirteen unbonded and one bonded PC simply-supported slab after elevated temperature were completed. The section of the slab was divided into strips along its depth according to the distribution of temperature field, and the strain-stress relationship of concrete and steel after elevated temperature were introduced, and then the moment-curve of the PC slab was obtained based on equilibrium equations of force and moment on slab section, therefore, the deflection of slab could be obtained by curve integral of section. The experimental results show that: the prestress losses in stress wire in the PC slab after elevated temperature increases with the rise of the effective prestress at ambient temperature and the heating time. The rate of load-bearing capacity degradation of the PC slab increases with the rise of heating time and load level and the decrease of concrete cover. The rate of load-bearing capacity degradation of bonded PC slab after elevated temperature is larger than that of the unbonded PC slab in the same condition. The residual stress and ultimate stress in unbonded stress wire in the PC slab were obtained by fitting curve of experimental data, and the calculation method for normal section load-hearing capacity of the PC slab was established. [ABSTRACT FROM AUTHOR]

The article presents a study regarding the development of real-time polymerase chain reaction (RT-PCR) for the quantification of cytokine gene expression in mice. It states that the production of cytokines is essential in the regulation of immune response. It mentions that RT-PCR is precise in quantifying the messenger RNA cytokine profile.

PURPOSE: To investigate the expression of basic fibroblast growth factor (bFGF) in infant's peripheral blood and tumor blood of vascular malformation and peripheral venous blood of hemangioma, and the possibility to differentiate hemangioma from vascular malformations by detecting bFGF level in peripheral blood. METHODS: The level of bFGF in peripheral blood (49 vascular malformations ,32 hemangioma cases and 23 normal cases) and tumor blood (14 venous malformations) of infants was measured by ELISA.SPSS11.5 software package was used to analyze the data and student's t test and ANOVA were used to determine the difference between different groups. RESULTS: The expression of bFGF in tumor blood from infants with venous malformations was significantly higher than that in peripheral blood (P<0.05); No significant difference of bFGF level in peripheral blood was found between hemangioma, vascular malformation and normal infants (P>0.05). CONCLUSIONS: The level of bFGF in tumor blood of from infants with venous malformation was higher than that in peripheral blood; Examination of bFGF in peripheral blood can not differentiate hemangioma from vascular malformations. [ABSTRACT FROM AUTHOR]

This paper derived optimal training sequences for the multiple antennas of the multiple cells in multiple input and multiple-output orthogonal frequency division multiplexing (MIMO-OFDM)-based cellular systems, and presented an iterative channel estimation algorithm with co channel interferences (CCIs) suppression for better estimation. The computer simulation shows that the proposed estimator can achieve much better performance than the conventional channel estimator over multipath fading channels and improve the system performance. [ABSTRACT FROM AUTHOR]

In order to meet the high requirements of future high-speed and high acceleration tactical missiles for shell bearing capacity and heat protection function, the integrated structure-heat protection ϕ480 mm composite shell was prepared by dry winding process, in which the structure layer adopted T700 carbon fiber/cyanate ester composite, and the heat protection layer adopted composite heat protection structure. The internal pressure, acoustic emission and hydraulic burst tests had been done for integrated structure-heat protection ϕ480 mm shell. The strain variation law, the damage type and damage location of ϕ480 mm composite shell were researched. The structural integrity of external heat protection materials was evaluated. The capacity of bearing internal pressure load was also assessed for the integrated structure-heat protection ϕ480 mm composite shell. The results show that the strain of ϕ480 mm composite shell is linear with the pressure and increased with the raising pressure. The acoustic emission signals, such as resin cracking, monofilament fracture, fiber bundle fracture and delamination are distributed in the dome areas under the internal pressure. The Felicity ratio of ϕ480 mm composite shell is 0.96 after secondary loading. The bursting pressure of ϕ480 mm composite shell is 18.6 MPa, and the vessel characteristic coefficient reaches 42.1 km. The fiber fracture occurs in the dome areas. A small amount of fiber fuzzing, broken wire and whitening appear on the surface of the heat resistant layer material, and no delamination and shedding occur, maintaining good structural integrity.

Type 2 diabetes mellitus has become one of the serious public health problems in the world. In recent years, whole grain foods and ketogenic foods, as representative foods, have been reported to have the effects of controlling blood glucose and blood lipids, losing body weight, and reducing the use of drugs for type 2 diabetes patients by improving the nutritional structure of fat, carbohydrates and protein. In this study, we summarize the origin of research among whole grain foods, ketogenic foods and T2DM and the role and mechanism of whole grain and ketogenic foods in controlling the development of T2DM; comb the development, utilization, existing problems and development trends of whole grains and ketogenic foods. There are different problems in the development of these two categories of foods. With the continuous development of involving these two foods in the treatment of T2DM, it is very necessary to develop a series of whole grain foods and ketogenic foods with balanced nutrition and delicious flavors.

Sensitivity of the coal reservoir permeability to temperature and stress is one of the basic parameters for evaluating the physical properties of deep coal reservoir. Using the heating and overburden pressure permeability-porosity tester, the permeability and porosity of the anthracite samples from the Chengzhuang, Jincheng, Shanxi, were measured. Combining with the pore structure and other data, the sensitivity of high rank coal to temperature and pressure was discussed. It is show that the porosity and permeability of high-rank coal is negatively correlated to the pressure in a power function, reduce rapidly as the pressure rises when pressure is lower, and tend to be stable in higher pressure phase. High-rank coal permeability is not sensitive to temperature, decreases with the increase of temperature when the pressure is less than 2 MPa, and has not significant correlation with temperature once the pressure is higher than 2 MPa. Therefore, the pressure is a major effect factor to the porosity and permeability of high-rank coal, and the temperature has less influence on the porosity and permeability. Based on curvature analysis method, stress sentivity of permeability of high rank coal of Chengzhuang Mine pressure sensitivity was analyzed. Compared with Zhengzhuang and Haneheng high rank coal, Chengzhuang coal has stronger stress sensitivity in low pressure stage. Therefore, reasonable pumping system of coalbed methane development in Chengzhuang Mine should be made to avoid negative effect due to stress sensitivity of permeability. [ABSTRACT FROM AUTHOR]

Objective: To investigate the correlation of peripheral blood T lymphocyte subsets with overall survival (OS) and clinical baseline characteristics in mantle cell lymphoma (MCL)., Methods: The clinical data of 55 MCL patients who were newly diagnosed in the Department of Hematology, Second Hospital of Shanxi Medical University from January 2012 to July 2022 were analyzed retrospectively. The percentages of T lymphocyte subsets and CD4 + /CD8 + ratio in peripheral blood were detected by flow cytometry, and their correlation with clinical characteristics of patients were analyzed. Kaplan-Meier method was used for survival analysis and survival curves were drawn. Log-rank test was used for univariate analysis, while Cox proportional hazards model was used for multivariate analysis., Results: The median follow-up was 40(1-68) months, and the median overall survival (OS) was 47 months. Among the 55 patients, 30(54.5%) patients had a decrease in peripheral blood CD4 + T lymphocyte, while 17(30.9%) patients had a increase in peripheral blood CD8 + T lymphocyte, and 20(36.4%) patients had a decrease in CD4 + /CD8 + ratio. There were no significant correlations between CD4 + /CD8 + ratio and sex, age, Ki-67, B symptoms, leukocytes, hemoglobin, lymphocytes, platelets, albumin, lactate dehydrogenase (LDH), β 2 -microglobulin, splenomegaly, bone marrow invasion, primary site and MIPI score. Survival analysis showed that patients with CD4 + T cell >23.3%, CD8 + T cell ≤33.4% and CD4 + /CD8 + ratio >0.6 had longer OS ( P =0.020, P <0.001, P <0.001). Univariate analysis showed that Ki-67>30%, LDH>250 U/L, splenomegaly, bone marrow involvement, CD4 + T cells ≤23.3%, CD8 + T cells >33.4%, CD4 + /CD8 + ratio ≤0.6 were adverse prognostic factors affecting OS of MCL patients. Multivariate analysis showed that CD4 + /CD8 + ratio ≤0.6 ( HR =4.382, P =0.005) was an independent adverse prognostic factor for OS of MCL patients., Conclusions: Low CD4 + /CD8 + ratio is associated with poor prognosis in MCL, and the CD4 + /CD8 + ratio can be used as an important indicator to evaluate the prognosis risk in MCL patients.

Objective: To investigate clinical effect of tendons pulling,poking and kneading for the treatment of external humeral epicondylitis., Methods: From January 2018 to December 2021,a multicenter randomized controlled study was performed to collect 192 patients with external humeral epicondylitis in Wangjing Hospital,Beijing Dianli Hospital,and Beijing Fengsheng Osteotraumatology Hospital,respectively,and they were divided into treatment group and control group by random number table method. There were 96 patients in treatment group,including 36 males and 60 females,aged from 28 to 60 years old with an average of (41.20±5.50) years old;the course of disease ranged from 1 to 14 days with an average of (5.24±1.35) days;they were treated once every other day for 2 weeks. There were 96 patients in control group ,including 33 males and 63 females,aged from 26 to 60 years old with an average of (43.35±7.75) years old;the course of disease ranged from 1 to 14 days with an average of (5.86±1.48) days;they were treated with topical voltaalin combined with elbow joint fixation for 2 weeks. Visual analogue scale (VAS) and Hospital for Surgery Scoring System (HSS) elbow pronation and supination angles,wrist metacarpal flexion and dorsal extension angles,elbow tenderness between two groups were compared before treatment and at 1,3,5,7,11 and 13 days after treatment;Hospital for Surgery Scoring System 2 (HSS2) was compared before treatment and the final treatment., Results: All patients were followed up for 10 to 14 days with an average of (12±1.6) days. VAS between treatment group and control group before treatment were 6.83±1.36 and 6.79±1.58,respectively,and decreased to 1.49±1.09 and 2.11±1.81 after the final treatment. VAS of treatment group were significantly lower than those of control group at 1,3,5,7,9,11 and 13 days after treatment ( P <0.05). HSS between two groups were 61.73±11.00 and 36.47±12.45 before treatment,respectively,and increased to 94.42±5.9 and 91.44±9.11 at the final treatment. HSS of treatment group were significantly higher than those of control group at 1,3,5,7,9,11 and 13 days after treatment ( P <0.05). On the 5th day after treatment,the external and internal rotation angles of elbow in treatment group were (66.41±12.69) ° and (66.35±13.54) °,while those in control group were (62.08±16.03) ° and (61.77±16.35) °. On the 7th day after treatment,the external and internal rotation angles of elbow were (69.79±12.64) ° and (70.02±13.55) ° in treatment group,and (65.28±15.86) ° and (65.09±16.67) ° in control group. Elbow joint motion in treatment group was higher than that in control group ( P <0.05). On the 5th day after treatment,angles of wrist dorsiflexion and palm flexion were (39.43±15.94) ° and (46.68±11.10) ° in treatment group,and (38.51±18.49) ° and (44.27±13.58) ° in control group. On the 7th day after treatment,angles of wrist dorsiflexion and palm flexion were (42.52±16.50) ° and (49.23±10.96) ° in treatment group,and (41.18±20.09) ° and (46.64±14.63) ° in control group. The motion of wrist joint in treatment group was higher than that in control group ( P <0.05). On the 13th day after treatment,HSS2 in treatment group 93.61±6.32 were higher than those in control group 92.06±7.94( P <0.05). There was no significant difference in elbow tenderness between two groups at each time point ( P >0.05)., Conclusion: Voltaren external treatment combined with elbow fixation and tendons pulling,poking and kneading could effectively improve symptoms of external humeral epicondylitis. Compared with voltaren external treatment,tendons pulling,poking and kneading has advantages of longer analgesic time and better elbow function recovery.

Yiyi Fuzi Baijiang Powder(YFBP), originating from Synopsis of the Golden Chamber, is a classic prescription composed of Coicis Semen, Aconiti Lateralis Radix Praeparata, and Patriniae Herba for the treatment of abscesses and pus discharge. This article presented a systematic analysis of the clinical application of YFBP, including the indicated diseases, the number of cases, efficacy, dosage, administration methods, and compatibility with other drugs. The analysis reveals that YFBP has a wide range of clinical applications. It is commonly used, often with modifications or in combination with western medicine, for diseases in the fields of gastroente-rology, gynecology, urology, dermatology, and others. And most of the Traditional Chinese Medicine(TCM) evidence involved in these diseases are damp-heat evudence. The prescription shows rich variations in clinical administration methods, and most of which are the treatment of aqueous decoction of it. The therapeutic effect is also significant, and the total effective rate of clinical treatment is re-latively high. Additionally, this article summarized the pharmacological research on YFBP and found that it possessed various pharmacological effects, including anti-inflammatory, antioxidant, anticancer, and immune-modulating properties. Finally, correlation analysis was conducted on the main diseases, TCM types, prescription doses, pharmacological effects and action targets of YFBP, which to show the relationship between these five aspects in a visual form, reflecting the relationship between its clinical application and modern pharmacological effects. These findings provide a reference basis for further development and research on YFBP.