Expression and significance of basic fibroblast growth factor in infant vascular anomalies.

PURPOSE: To investigate the expression of basic fibroblast growth factor (bFGF) in infant's peripheral blood and tumor blood of vascular malformation and peripheral venous blood of hemangioma, and the possibility to differentiate hemangioma from vascular malformations by detecting bFGF level in peripheral blood. METHODS: The level of bFGF in peripheral blood (49 vascular malformations ,32 hemangioma cases and 23 normal cases) and tumor blood (14 venous malformations) of infants was measured by ELISA.SPSS11.5 software package was used to analyze the data and student's t test and ANOVA were used to determine the difference between different groups. RESULTS: The expression of bFGF in tumor blood from infants with venous malformations was significantly higher than that in peripheral blood (P<0.05); No significant difference of bFGF level in peripheral blood was found between hemangioma, vascular malformation and normal infants (P>0.05). CONCLUSIONS: The level of bFGF in tumor blood of from infants with venous malformation was higher than that in peripheral blood; Examination of bFGF in peripheral blood can not differentiate hemangioma from vascular malformations. [ABSTRACT FROM AUTHOR]