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BACKGROUND: There have been many studies on adjacent vertebral fractures in elderly female patients with osteoporotic vertebral compression fractures, but their related risk factors are still in debate. There are also few studies on how to intuitively present their risks for clinical application. OBJECTIVE: To analyze the risk factors of adjacent vertebral refracture in senile women with osteoporotic vertebral compression fracture and construct a Nomogram prediction model. METHODS: A total of 268 elderly female patients with osteoporotic vertebral compression fracture who came to Ganzhou People’s Hospital for treatment from January 2018 to November 2022 were selected and divided into study group (adjacent vertebral refracture, n=31) and control group (no adjacent vertebral refracture, n=237) according to whether adjacent vertebral refracture occurred 3 months after percutaneous vertebroplasty. General clinical data were compared between the two groups. Multivariate Logistic regression analysis was conducted to analyze the independent risk factors of adjacent vertebral refracture in elderly women with osteoporotic vertebral compression fracture. A Nomogram prediction model was constructed by R software “rms” package. RESULTS AND CONCLUSION: (1) There were statistically significant differences in age, menopause age, body mass index, fracture history, number of fractured vertebra before surgery, bone cement leakage, bone density, postoperative kyphotic deformity angle, and preoperative Oswestry disability index between the two groups (P < 0.05). (2) Multivariate logistic regression analysis results showed that age (> 69 years old), menopause age (≤ 51 years old), body mass index (> 24.7 kg/m² ), fracture history (presence), number of fractured vertebra before surgery (≥ 2), and postoperative kyphotic deformity angle (> 13°) were independent risk factors for adjacent vertebral refracture in elderly female osteoporotic vertebral compression fracture patients (P < 0.05). (3) Nomogram prediction model decision curve results displayed that when the risk threshold was > 0.09, this prediction model provided significant additional clinical net benefit. (4) These findings indicate that older age, lower menopause age, higher body mass index, history of fracture, more vertebra fractures before surgery, and larger kyphosis angle after surgery are independent factors for adjacent vertebral refracture in elderly women with osteoporotic vertebral compression fracture. This Nomogram prediction model will provide important strategic guidance for the prevention and treatment of adjacent vertebral refracture in elderly women with osteoporotic vertebral compression fracture. [ABSTRACT FROM AUTHOR]

Objective: To explore the relationship between relapse tendency and psychological craving in female methamphetamine (MA)-dependent young adults, focusing on the roles of self-control and future time perspective. Methods: A total of 340 MA-dependent young adults from two women's compulsory isolation drug rehabilitation centers in Sichuan Province were included. Participants were assessed with the Relapse Tendency Questionnaire (RTQ), Obsessive Compulsive Drug Use Scale (OCDUS), Drug Abuser Self-Control Ability Questionnaire (DASAQ) and General Future Time Perspective Scale (GFTPQ). The moderated mediation model was analyzed by using the SPSS macro program PROCESS (version4. 2). Results: The RTQ scores were positively correlated with the OCDUS scores (r=0.45, P<0.001). The DASAQ scores partially mediated the relationship between the scores of OCDUS and RTQ. accounted for 37.91% of the total effect. The GFTP scores moderated the relationship between the scores of the OCDUS, DASAQ and RTQ (B=0. 18. 0. 19, P<0.001). Conclusion: The influence of psychological craving on relapse tendency in female MA-dependent young adults exhibits a moderated mediating effect, suggesting the potential of enhancing self-control and future time perspective for preventing relapse and improving detoxification efficiency. [ABSTRACT FROM AUTHOR]

Background Stress urinary incontinence (SUI) is one of the common diseases in middle-aged and elderly women, which seriously affects their quality of life and physical and mental health. Internet medicine has the advantages of flexibility, privacy and accessibility, which can be used as an effective approach of self-management intervention for urinary incontinence patients. However, its effectiveness on the clinical treatment of middle-aged and elderly female SUI patients is unclear. Objective To explore the effects of Internet-based self-management intervention on improving clinical symptoms, self-efficacy, and psychological status in middle-aged and elderly female SUI patients. Methods A total of 120 middle-aged and elderly female SUI patients treated in the Air Force 986 Hospital of PLA from January to December 2022 were recruited. They were randomly assigned into control group (n=60) and experimental group (n=60) by double-blind random number table method. Patients in both groups were given conventional pelvic floor muscle training (PFMT), with 20 minutes per day, once every other day for a course of 10 times of PFMT, and those in the experimental group were additionally given Internet-based self-management intervention for 6 months. Outpatient re-examination and follow-up visits were conducted before treatment and 3 and 6 months after treatment. Clinical symptoms of SUI in middle-aged and elderly female patients were evaluated by surveying the International Consultation on Incontinence Questionnaire Short Form (ICI-Q-SF) and 1-hour pad test, thus determining the clinical efficacy. The Broome Pelvic Muscle Self-efficacy Scale (BPMSES) was used to evaluate the self-management efficacy. The Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to evaluate the anxiety and depression status, respectively. Results The ICI-Q-SF scores of experimental group at 3 months [ (6.58±3.91) points vs. (9.27±3.11) points, P

ObjectiveTo analyze the trends in breast cancer incidence and mortality from 1990 to 2019 and to predict the age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) of breast cancer from 2020 to 2029 in the world female population, providing a reference for the prevention and control of female breast cancer in the world. MethodsData on breast cancer incidence and mortality in the global female population from 1990 to 2019 were collected from the Global Burden of Disease (GBD) 2019 study. Incidence count, incidence rate, ASIR, death count, mortality rate, and ASMR were used for descriptive analysis. Average annual percentage change (AAPC) was used to analyze trends in breast cancer incidence and mortality from 1990 to 2019. The age-period-cohort (APC) model was used to estimate the age effect, period effect, and cohort effect on breast cancer incidence and mortality risk in the world female population; the autoregressive integrated moving average (ARIMA) model was used to predict trends in breast cancer incidence and mortality from 2020 to 2029 in the female population. ResultsIncreases in breast cancer in the global female population from 1990 to 2019 were observed in incidence number (867 620.84 to 1 977 211.62), incidence rate (32.67/100 000 to 51.27/100 000), ASIR (40.12/100 000 to 45. 86/100 000), number of deaths (375 016.06 to 688 562.26), and mortality rate (14.12/100 000 to 17.85/100 000), with total percentage changes of 127.89%, 56.93%, 14.31%, 83.61%, and 26.42%, respectively. The breast cancer ASMR decreased from 17.76/100 000 in 1990 to 15.88/100 000 in 2019, with an overall percentage change of – 10.54%. Joinpoint regression analysis showed that breast cancer ASIR for the global female population generally increased from 1990 to 2019 (AAPC = 0.44, P < 0.001), while breast cancer ASMR generally decreased (AAPC = – 0.37, P < 0.001). Trends in female breast cancer incidence and mortality varied across global regions with different levels of socio-demographic index (SDI) from 1990 to 2019. The ASIR generally increased in global regions with different SDI levels. The ASMR generally increased in the middle, low-middle, and low SDI regions, but generally decreased in the high and high-middle SDI regions from 1990 to 2019 (all P < 0.001). The APC model analysis showed that the age effects on breast cancer incidence and mortality rates in the global female population generally increased with age, with coefficients increasing from – 2.878 and – 2.946 at ages 20 – 24 years to 0.706 and 1.053 at ages 75 – 79 years, respectively. Period effects on breast cancer incidence and mortality also showed increasing trends, with coefficients increasing from – 0.310 and – 0.206 in 1990 – 1994 to 0.296 and 0.235 in 2015 – 2019, respectively. However, cohort effects on breast cancer incidence and mortality generally decreased, with coefficients decreasing from 0.848 and 0.866 for the 1915 – 1919 birth cohort to – 0.575 and – 0.672 for the 1995 – 1999 birth cohort, respectively. ARIMA model predictions showed that the global female breast cancer ASIR will continue to increase while the ASMR will continue to decrease from 2020 to 2029, with predicted ASIR and ASMR of 47.86/100 000 and 15.31/100 000, respectively, in 2029. ConclusionFrom 1990 to 2019, the ASIR for breast cancer has generally increased while the ASMR has generally decreased in the global female population. From 2020 to 2029, the ASIR is projected to continue to increase while the ASMR is projected to continue to decrease.

ObjectiveTo understand the incidence and death of female breast cancer patients and the premature death caused by breast cancer in Putuo District of Shanghai, and to reduce the incidence of breast cancer, mortality and the probability of early death, and to provide reference for realizing the control target of the probability of early death of major chronic diseases.MethodsThe incidence and death data of the registered female residents with breast cancer in Putuo District of Shanghai from 2004 to 2019 were collected using Shanghai Population-based tumor registration management system. The crude incidence rate, standardized incidence rate, crude mortality rate, standardized mortality rate, age-specific incidence rate, age-specific mortality rate and other indicators were calculated. The Joinpoint regression model was used to calculate the annual percentage change (APC) and average annual percentage change (AAPC) of breast cancer incidence, mortality and premature death probability, and to analyze the changing trend.ResultsFrom 2004 to 2019, the crude incidence of breast cancer in Putuo District of Shanghai increased from 75.76/105 to 95.77/105 (APC=2.26%, t=6.05, P

Polycystic ovary syndrome (PCOS) is a common metabolic disorder of the reproductive system in women of adolescent and childbearing age. In addition to ovulatory dysfunction, menstrual dysfunction and infertility, most patients suffer from endocrine abnormalities such as insulin resistance (IR), hyperandrogenemia (HA) and abdominal obesity. Ferroptosis, a highly iron-dependent programmed cell death mediated by the lipid peroxidation and the imbalance in the oxidative -antioxidant system is a hot research topic in reproductive medicine. The relevance of ferroptosis in PCOS has received much attention in recent years, and recent studies suggest that ferroptosis may be involved in the regulation of PCOS -associated metabolic disorders and affect reproductive function in women with PCOS by disrupting oocyte quality and uteroplacental function. To further enrich and improve the system of diagnosis, prevention, and prognosis assessment of PCOS, we summarize the mechanisms related to ferroptosis, systematically discusses the correlation between ferroptosis and the pathophysiology of PCOS, and its research progress in the treatment of PCOS. [ABSTRACT FROM AUTHOR]

BackgroundPer- and poly-fluoroalkyl substances (PFAS) are a class of emerging persistent organic pollutants, and their negative health impacts have been widely concerned. There is a lack of epidemiological studies on the associations of PFAS exposure with lipid homeostasis. ObjectiveTo investigate the associations of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure with blood lipid levels and dyslipidemia in middle-aged and elderly women. MethodsThis study was based on 795 middle-aged and elderly women from a female sub-cohort of the Dongfeng-Tongji cohort study, excluding the participants without blood lipid measurements and/or reported use of lipid-lowering drugs at baseline. The concentrations of plasma PFOS and PFOA were measured by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The concentrations of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were measured using an automatic analyzer. The normally distributed continuous variables were presented as mean ± standard deviation (\begin{document}$ \bar{x}\pm s) $\end{document}, while the skewedly distributed continuous variables were presented as median (M) and the 25th and 75th percentiles (P25, P75). Generalized linear models (GLM), generalized additive models (GAM), and logistic regression models were applied to evaluate the associations of PFOS and PFOA exposure with blood lipid levels and the risk of dyslipidemia. Stratified analyses were also implemented to explore potential modification effects of sociodemographic characteristics, lifestyles, and menopause on associations of PFOS and PFOA exposure and blood lipids. ResultsThe \begin{document}$ \bar{x}\pm s $\end{document} of baseline age for the study participants was (59.4±8.6) years old, and their baseline body mass index (BMI) was (24.3±3.4) kg·m−2. The M (P25, P75) of baseline plasma concentrations for PFOS and PFOA were 9.96 (6.24, 15.09) μg·L−1 and 1.20 (0.84, 1.80) μg·L−1 respectively. The GLM analysis showed that plasma concentration of PFOS was positively associated with serum HDL-C [b (95%CI): 0.04 (0.01, 0.07)]. The plasma concentration of PFOA was also positively associated with serum TC [b (95%CI): 0.05 (0.02, 0.08)] and serum LDL-C [b (95%CI): 0.05 (0.01, 0.09)]. No significant association was observed between plasma PFOS and serum TC, TG, or LDL-C, nor between plasma PFOA and serum TG or HDL-C. The stratified analyses showed that the association between PFOA and LDL-C was significant among the participants aged

Objective To provide a neuroimaging basis for exploring the role of the prefrontal cortex in human urinary control function. Methods Hemodynamic data from the prefrontal cortex of the brain during the task of pelvic floor muscle contraction from 20 healthy female volunteers were collected using functional near-infrared spectroscopy （fNIRS） under two different states of bladder filling and emptying， and these data were processed accordingly to compare the differences in the activation state among different brain compartments of the prefrontal cortex by analyzing the Beta values corresponding to the relative amount of changes in the concentration of oxyhemoglobin extracted from each individual channel. Results A total of 30 channels were activated during bladder filling， whereas 8 channels were activated during bladder emptying （all P < 0.05）， including 7 co-activated channels. The prefrontal cortex activation was more significant during bladder filling than bladder emptying， and the activation was predominantly in the right prefrontal cortex， with the differences mainly in the right dorsolateral prefrontal cortex and frontopolar cortex （all P < 0.05）. Conclusions The prefrontal cortex can be activated by pelvic floor muscle contraction. Under the state of bladder filling， the prefrontal cortex may perceive the pressure change of the bladder through neural reflex activity and thus participate in the regulation of the voluntary pelvic floor muscle contraction， plays a role in human urinary control function. The right dorsolateral prefrontal cortex region possibly plays a more significant role in this process.

Papillary hidradenoma is a rare benign tumor that occurs mostly in women in the skin of the anogenital region. Anal papillary hidradenomas are especially rare in Japan. This paper reports three cases of papillary hidradenoma of the anus. Case 1: A 47-year-old woman presented with a perianal nodule that had been enlarging since the previous year, which she had first noticed 10 years ago. The nodule appeared as a 10 mm well-circumscribed skin tumor on the right anterior side of the anus, with a pinhole dent on top. Local excision was performed. Case 2: A 37-year-old woman had noticed a perianal nodule 3 years ago. She complained of pain during the previous year. The nodule appeared as a 3-mm skin tumor with erosion on the right posterior side of the anus. Local excision was performed. Case 3: A 50-year-old woman had noticed a perianal nodule 6 months ago. The nodule appeared as a 9 mm tumor on the left side of the anus. Local excision was performed. The pathological findings of all of the above cases indicated papillary hidradenoma. Given its paucity of distinctive features, papillary hidradenoma presents diagnostic difficulties. On rare occasions, it is mistaken for adenocarcinoma based on pathological and visual findings, and cases that include carcinoma have been reported. Clinicians should be aware of the occurrence of papillary hidradenomas in the anal region; when suspected, complete resection and further pathological examination are recommended. [ABSTRACT FROM AUTHOR]

Oxidative stress is closely linked to the decline inof female fertility caused by various factors. Antioxidants, which can counteract oxidative stress. have been increasingly used as adjunctive therapy for women with reduced fertility. However, there are limited clinical studies on whether antioxidants can enhance fertility in women with low reproductive capacity and improve pregnancy outcomes, with inconsistent results and generally low-quality evidence. This paper reviewed the impact of oxidative stress on female fertility and discusses the progress of research on the application of antioxidants in common conditions that lead to reduced female fertility and are closely associated with oxidative stress, such as polycystic ovary syndrome, endometriosis, and unexplained infertility, aiming to provide a reference for clinical treatment. [ABSTRACT FROM AUTHOR]

Copyright of Practical Oncology Journal is the property of Journal of Practical Oncology Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In recent years the progress of targeted therapy and immunotherapy has developed rapidly, such as poly (ADP-ribose) polymerase inhibitor (PARPi) and immune checkpoint inhibitors (ICI) have changed the traditional treatment pattern of gynecologic tumors, but some patients have limited efficacy or develop drug resistance. Preclinical studies have found that PARPi damages DNA repair process, results in increasing tumor mutation burden and tumor -specific antigen neoantigens, modulates the tumor microenvironment, and stimulates the production of tumor infiltrating lymphocytes (TIL) and promotes anti-tumor immune response, which providing a theoretical basis for the combination treatment of PARPi and ICI. Recently, many clinical studies have found that the combination of PARPi and ICI can significantly improve the prognosis of patients with gynecological malignant tumors. [ABSTRACT FROM AUTHOR]

Objective To provide a neuroimaging basis for exploring the role of the prefrontal cortex in human urinary control function. Methods Hemodynamic data from the prefrontal cortex of the brain during the task of pelvic floor muscle contraction from 20 healthy female volunteers were collected using functional near-infrared spectroscopy (fNIRS) under two different states of bladder filling and emptying, and these data were processed accordingly to compare the differences in the activation state among different brain compartments of the prefrontal cortex by analyzing the Beta values corresponding to the relative amount of changes in the concentration of oxyhemoglobin extracted from each individual channel. Results A total of 30 channels were activated during bladder filling, whereas 8 channels were activated during bladder emptying(all P<0.05),including 7 co-activated channels. The prefrontal cortex activation was more significant during bladder filling than bladder emptying, and the activation was predominantly in the right prefrontal cortex, with the differences mainly in the right dorsolateral prefrontal cortex and frontopolar cortex(all P<0.05).Conclusions The prefrontal cortex can be activated by pelvic floor muscle contraction. Under the state of bladder filling, the prefrontal cortex may perceive the pressure change of the bladder through neural reflex activity and thus participate in the regulation of the voluntary pelvic floor muscle contraction, plays a role in human urinary control function. The right dorsolateral prefrontal cortex region possibly plays a more significant role in this process. [ABSTRACT FROM AUTHOR]

BackgroundDepressive disorders are prevalence among adolescents， with a higher incidence in females compared to males， often accompanied by more severe depressive symptoms. Sertraline is commonly prescribed for adolescent depressive disorder， however， its efficacy is only evident in certain patients. Currently， there is limited research on predicting the therapeutic efficacy of sertraline in female adolescents with depressive disorder.ObjectiveTo explore the relationship between personality traits， psychological resilience， coping style and the clinical efficacy of sertraline treatment in female adolescents with first-episode depressive disorder， in order to provide references for the treatment of this population.MethodsA total of 112 female adolescent patients with first-episode depressive disorder， meeting the diagnostic criteria of the International Classification of Diseases （tenth edition） （ICD-10）， and undergoing a 4-week treatment regimen with sertraline， were selected from the Second People's Hospital of Guizhou Province from February 2019 to January 2021.General demographic questionnaire， NEO Five-Factor Inventory （NEO-FFI）， Resilience Scale for Chinese Adolescents （RSCA）， Coping Style Scale for Middle School Students （CSSMSS）， Hamilton Anxiety Scale （HAMA） and Hamilton Depression Scale-17 item （HAMD-17） were used for assessment. Logistic regression analysis was used to investigate the factors influencing the clinical efficacy of sertraline in the treatment of female adolescents with first-episode depressive disorder.ResultsNeuroticism （β=-0.115， 95% CI： 0.807~0.984） could negatively predicted the therapeutic efficacy of sertraline in female adolescents with first-episode depressive disorder， whereas agreeableness （β=0.129， 95% CI： 1.025~1.264） and RSCA score （β=0.062， 95% CI： 1.004~1.128） could positively predict its therapeutic efficacy.ConclusionHigh neuroticism， low agreeableness and low psychological resilience may be the risk factors for the poor therapeutic effect of sertraline in the treatment of female adolescents with first-episode depressive disorder. ［Funded by 2019 Guiyang Science and Technology Program （number， Zhuke Contract ［2019］9-3-1）］

Objective To obtain guiding recommendations for the development of fertility preservation in female patients of reproductive age, so as to promote the scientific, standardized and orderly implementation of fertility preservation work. Methods A previous questionnaire survey was used to determine the preliminary recommendations, a modified Delphi method was used to invite 18 domestic experts of fertility preservation to conduct two rounds of expert consultation. Then we adjusted and summarized recommendations according to the results of the consultation. Results Finally, 14 guiding recommendations for the development of fertility preservation in female patients of reproductive age were obtained according to the results of the Delphi consultation, including 5 recommendations at technical level, 5 recommendations at political level and 4 recommendations at educational level. At technical level, it was proposed to establish a standardized operation process; at political level, it was proposed to improve the relevant legislation of fertility preservation in China to protect the safety and interests of patients; at educational level, it was suggested to take various forms to promote the mass dissemination of fertility preservation knowledge. Conclusion Guiding recommendations for fertility preservation in female patients of reproductive age can provide detailed and comprehensive guidance for promoting fertility preservation in female patients of reproductive age in Shanghai, and provide reference for carrying out fertility preservation in other regions. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Applied Entomology is the property of Chinese Journal of Applied Entomology, Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

BACKGROUND: Studies have shown that there are significant differences in the geometric morphology of the distal femur of different races and genders, and there are more short female patients in southern China, so the phenomenon of overhanging or insufficient coverage of imported knee prostheses often occurs during surgery. OBJECTIVE: To investigate the characteristics of distal femur bones in southern Chinese women and compare them with imported joint prostheses by simulating the three-dimensional reconstruction of the distal femur bone and matching the femoral side after osteotomy with common imported joint prostheses. METHODS: From January to December 2021, 120 female volunteers underwent a CT scan of knee joints. The images were imported into Mimics 20.0 software in Dicom format for three-dimensional reconstruction and then imported into Magic 22.0 software to simulate osteotomy by posterior cruciate ligament preserved total knee arthroplasty and to conduct a matching study with a normal imported joint prosthesis. RESULTS AND CONCLUSION: (1) The functional anteroposterior dimension (fAP) of the distal femur and Persona matched prosthesis had a total overhang rate of 25%(30/120). The fAP≤47 mm group had an overhang than the other groups (P < 0.05). The poor coverage rate of Triathlon prosthesis was 12.5%(15/120), and poor coverage was more likely in fAP>53 mm group than in fAP≤53 mm group (P < 0.05). (2) The total poor coverage rate of femoral intercondylar width matching with Triathlon prosthesis was 27.5%(33/120). Therefore, the poor coverage rate of bone surface in the central region of the distal femur was more likely in the fAP≤47 mm group than in other groups (P < 0.05). The overhang rate of Journey II was 21.6%(26/120), and the overhang rate was higher in the fAP>53 mm group than in the fAP≤53 mm group (P < 0.05). (3) Journey II CR prosthesis had the largest difference with the length of the anterior mediolateral diameter of the femur, which was easy to hang out on the anterolateral side of the femoral prosthesis. The Persona CR prosthesis has the largest difference with the length of the posterior mediolateral diameter of the femur, which is easy to be poorly covered in the posterior medial part of the prosthesis. It is recommended to increase the femoral prosthesis with reduced mediolateral diameter in the fAP≤47 mm group and add wider and narrower sizes than the conventional size of intercondylar width, and optimize the anterolateral angular arc design of the femoral prosthesis to improve the matching of posterior cruciate ligament reserved knee prosthesis. [ABSTRACT FROM AUTHOR]

Gynecological malignant tumor is a serious threat to women′s health, with high morbidity and mortality among various female diseases. The key reason lies in the inadequate curative effect of traditional chemotherapy on relapsed and drug-resistant patients. In recent years, to explore the mechanism of chemotherapy resistance of tumor cells and to develop new chemotherapy reversal agents has become a focus of gynecological cancer researchers. Exosomes are a kind of multivesicular bodies originated from the formation of intracellular lysosomal particle invaginations, with biological properties such as low immunogenicity, innate targeting and acquired targeting, and high delivery efficiency. Therefore, exosomes can be used as an ideal, natural nanocarriers for drug delivery, which can not only reduce tumor resistance to chemotherapy drugs, improving the therapeutic effect of drugs, but also reduce the toxic and side effects of chemotherapy drugs on the whole body. This review summarizes the research progress of exosomes as drug carriers in drug-resistant treatment of gynecological tumors in order to to providing assistance in the clinical treatment of gynecological tumors. [ABSTRACT FROM AUTHOR]

Background Depressive disorders are prevalence among adolescents, with a higher incidence in females compared to males, often accompanied by more severe depressive symptoms. Sertraline is commonly prescribed for adolescent depressive disorder, however, its efficacy is only evident in certain patients. Currently, there is limited research on predicting the therapeutic efficacy of sertraline in female adolescents with depressive disorder. Objective To explore the relationship between personality traits, psychological resilience, coping style and the clinical efficacy of sertraline treatment in female adolescents with first-episode depressive disorder, in order to provide references for the treatment of this population. Methods A total of 112 female adolescent patients with first-episode depressive disorder, meeting the diagnostic criteria of the International Classification of Diseases (tenth edition) (ICD-10), and undergoing a 4-week treatment regimen with sertraline, were selected from the Second People's Hospital of Guizhou Province from February 2019 to January 2021. General demographic questionnaire, NEO Five-Factor Inventory (NEO-FFI), Resilience Scale for Chinese Adolescents (RSCA), Coping Style Scale for Middle School Students (CSSMSS), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale-17 item (HAMD-17) were used for assessment. Logistic regression analysis was used to investigate the factors influencing the clinical efficacy of sertraline in the treatment of female adolescents with first-episode depressive disorder. Results Neuroticism (β =-0. 115,95% CI: 0. 807~0. 984) could negatively predicted the therapeutic efficacy of sertraline in female adolescents with first-episode depressive disorder, whereas agreeableness (β=0. 129,95% CI: 1. 025~1. 264) and RSCA score (β=0. 062,95% CI: 1. 004~1. 128) could positively predict its therapeutic efficacy. Conclusion High neuroticism, low agreeableness and low psychological resilience may be the risk factors for the poor therapeutic effect of sertraline in the treatment of female adolescents with first-episode depressive disorder. ［Funded by 2019 Guiyang Science and Technology Program. [ABSTRACT FROM AUTHOR]

Background With the rapid development of economy and society in China, the living standards and health care awareness have been improved significantly, the average life expectancy of our population is gradually prolonged, causing increasing population of perimenopausal women, therefore, the health management of perimenopausal women has become more important. Perimenopausal syndrome can be seen in women aged 40-65 years, which can seriously affect the physical and mental health and quality of life of patients. Objective To systematically review the incidence of perimenopausal syndrome in Chinese women aged 40-65 years. Methods PubMed, Embase, Web of Science, CNKI, Wanfang Data, CBM and VIP were searched by computer to collect cross-sectional studies on the occurrence of perimenopausal syndrome in Chinese women aged 40-65 years from inception to February 1, 2023. Two investigators independently screened the literature, extracted data and evaluated the quality of included literature. Meta-analysis was performed using Stata 17.0 software. Results A total of 62 cross-sectional studies were included, with a total sample size of 82 340 cases. Meta-analysis showed that the incidence of perimenopausal syndrome in Chinese women aged 40-65 years was 61.0%. The results of subgroup analysis showed that the incidence of perimenopausal syndrome in women aged 40-45 years, >45-50 years, >50-55 years, >55-60 years and >60 years was 42.6%, 53.8%, 64.6%, 59.7% and 56.1%, respectively. The incidence of perimenopausal syndrome in women aged 40-65 years with normal, disordered and postmenopausal menstrual status was 43.6%, 56.9% and 61.3%, respectively. The incidence of perimenopausal syndrome in women aged 40-65 years with and without chronic diseases was 85.9% and 68.3%, respectively. The incidence of perimenopausal syndrome was highest in women aged 40-65 years in Southwest China at 71.3%, and at 57.4%, 57.9%, 50.5%, 59.2%, 69.5%, and 68.6% in North, East, South, Northwest, Northeast, and Central China, respectively. The incidence of perimenopausal syndrome in women aged 40-65 years with education level of junior high school and below, high school or technical secondary school, university and above was 54.1%, 55.7% and 49.6%, respectively. The incidence of perimenopausal syndrome in Han Chinese and ethnic minority women aged 40-65 years was 62.1% and 64.7%, respectively. Conclusion The incidence of perimenopausal syndrome is high in women aged 40 to 65 years in China. Among them, women aged >50-55 years, menopausal, suffering from chronic diseases, living in southwest region, with education level of high school or below, and ethnic minorities are at high risk of perimenopausal syndrome. We should pay attention to the prevention, screening and intervention of perimenopausal syndrome in relevant population to lay the foundation of elderly health in women.

Background With the population aging, mental health of the middle-aged and elderly adults is of great concern, especially in middle-aged and elderly women. Compared with urban women, rural women are more likely to suffer from mental diseases due to their poorer health status, lower education level and backward living conditions, however, the accessibility of mental health services among them is low. Objective To understand the prevalence of depression among middle-aged and elderly women in rural China and analyze its influencing factors, in order to provide empirical evidence for improving the mental health of middle-aged and elderly women. Methods From May to July 2021, the follow-up data of the 2018 China Health and Retirement Longitudinal Study (CHARLS) was extracted, and rural women aged 45 years and above were selected as the study subjects (n=6 736) . The scores of the simplified version of the Center for Epidemiologic Studies Depression Scale (CES-D) were used to determine the depression status of rural middle-aged and elderly women. Chi-square tests and multivariate Logistic regression model were used to analyze the influencing factors of the occurence of depressive symptoms among rural middle-aged and elderly women (including individual characteristics, health behaviors, social participation and utilization of medical services utilization) . Results The CES-D score of 6 736 rural middle-aged and elderly women was (20.0±6.9) , 42.46% (2 860/6 736) of whom had depressive symptoms. The results of multivariate Logistic regression analysis showed that satisfication with health status〔OR (95%CI) =0.40 (0.36, 0.45) 〕, sleep duration ≥6 h〔OR (95%CI) =0.48 (0.43, 0.54) 〕, Internet use〔OR (95%CI) =0.63 (0.50, 0.80) 〕 and satisfication with life 〔OR (95%CI) =0.25 (0.21, 0.30) 〕 were correlated with lower risk of depression; hysical disability〔OR (95%CI) =1.41 (1.16, 1.71) 〕, suffering from chronic diseases〔OR (95%CI) =1.35 (1.21, 1.50) 〕, receiving outpatient services within 1 month〔OR (95%CI) =1.25 (1.09, 1.43) 〕 and hospitalization services within 1 year〔OR (95%CI) =1.31 (1.13, 1.52) 〕 were correlated with higher risk of depression. Conclusion Based on the results of this study, the depression status of middle-aged and elderly women in rural China is relatively severe and affected by individual characteristics, health behaviors, social participation, and the medical services utilization. It is recommended that governments and civil affairs departments at all levels pay close attention to the mental health of rural middle-aged and elderly women, especially through the intervention and prevention from multiple dimensions such as health promotion and education, medical service quality, and accessibility of information, in order to promote the construction of healthy villages and process of health aging in China.

BackgroundCompared with male adolescents， depression among female adolescents is of higher prevalence and greater severity. The level of generalized trust correlates with the severity of depression， and attachment correlates with the level of generalized trust. Therefore， based on the mediating role of generalized trust between attachment and depression， this study explores the pathogenesis of depression in female adolescents.ObjectiveTo explore the mediating role of generalized trust between paternal， maternal and peer attachment and depression in female adolescents， so as to provide references for improving the depression of female adolescents.MethodsThis study included 73 female adolescents who met the diagnostic criteria for depressive disorder in the International Classification of Diseases， tenth edition（ICD-10） as well as received outpatient and inpatient treatment in Hangzhou Seventh People's Hospital between March 2022 and October 2022. Investigation was conducted by use of Revised Inventory of Parent and Peer Attachment （IPPA-R）， the Inclusive General Trust Scale （IGTS） and Children's Depression Inventory （CDI）. Pearson correlation analysis was used to explore the correlation between each scale score. The Bootstrap method was used to test the mediating role of generalized trust between attachment and depression.Results① CDI score in female adolescents with depression was negatively correlated with scores of paternal， maternal and peer attachment in IPPA-R （r=-0.463， -0.459， -0.447， P

Objective: To analyze the characteristics of intrauterine microbiota in infertile women with poor endometrial receptivity (PER) and identify its biomarkers. Methods: A total of 63 infertile women who visited our gynecology department from July 2021 to May 2022 were selected. According to ultrasound evaluation of endometrial receptivity, 40 cases were assigned to the PER group, while 23 cases with good endometrial receptivity were assigned to the control group. Endometrial tissue samples were collected from two groups of patients for 16S rRNA sequencing, to compare the characteristics and differences of intrauterine microbiota between the two groups. Results: There was no significant difference in the α diversity of intrauterine microbiota between the two groups(P＞0.05). However, the individual difference of intrauterine microbiota in PER group was significantly higher than that in control group (P＜0.05). The relative abundance of the dominant phylum Proteobacteria in the intrauterine of the PER group was significantly higher than that in the control group (50.52% vs. 19.35%). The dominant genus in both groups was Lactobacillus, but the relative abundance of Lactobacillus in the intrauterine of the PER group was significantly lower than that of the control group (21.76% vs. 45.96%), while the relative abundance of Ralstonia was significantly higher than that in the control group (18.01% vs. 0.48%). The relative abundance of Ralstonia_unclassified in the intrauterine microbiota of the PER group was significantly higher than that in the control group (18.01% vs. 0.48%), while the relative abundance of Lactobacillus_crispatus was significantly lower than that in the control group (3.82% vs. 23.78%). The Biomakers at the phylum, family, and genus levels of the intrauterine microbiota in the PER group are Proteobacteria; Burkholderiaceae, Vibrionaceae, etc; Ralstonia, Vibrio, etc. Conclusions: Infertility women with PER may have dysbiosis of the intrauterine microbiota, with a decrease in the relative abundance of Lactobacillus and an increase in the relative abundance of characteristic pathogenic bacteria such as Burkholderia and Ralstonia possibly related to PER. [ABSTRACT FROM AUTHOR]

Objective To explore the relationship between the age at first birth and mild cognitive impairment in the elderly rural women in Guizhou Province, so as to provide scientific basis for improving the current situation of their cognitive function. Methods A total of 1 653 elderly people from 5 townships in 2 counties (districts) of Guizhou Province were selected by multi-stage cluster sampling from July to August, 2019. Among them, 952 rural elderly women were investigated by questionnaire and physical examination, and the cognitive function was tested by Mini-Mental State Examination (MMSE). SPSS 26.0 software was used for univariate χ² or rank sum test, to compare the difference of the cognitive function in old age among rural womon with dfifferent dermgrophic characteristics and ages at first birth, and multivariate Logistic regression was used to analyze the influence of age at first birth on mild cognitive impairment. Results A total of 380 cases of mild cognitive impairment were detected, with a total detection rate of 39.92% (380/952). The results of univariate analysis showed that the differences in the rates of mild cognitive impairment among elderly rural women were statistically significant in terms of the following factors: age groups (χ²=45.074, P<0.001), ethnic groups (χ²=15.979, P<0.001), education level (χ²=10.394, P<0.05), BMI (χ²=18.961, P<0.001), daily exercise time (χ²=9.199, P<0.05), marital status (χ²=13.150, P<0.001), and smoking (χ²=4.318, P<0.05). In the age group of ≥ 70 years old, the detection rate of mild cognitive impairment was higher in those aged above 23 years than those aged ≤ 23 years at first birth, and the total scores of MMSE (Z=-1.961, P<0.05), immediate memory (Z=-2.108, P<0.05), and delayed memory (Z=-3.047, P<0.05) were significantly lower than the latter. The results of multivariate unconditional Logistic regression analysis in the age group ≥ 70 years old showed that the age at first birth > 23 years old (OR=1.537, 95%CI: 1.053-2.244) was a risk factor for mild cognitive impairment. Conclusion The detection rate of mild cognitive impairment is high in rural elderly women in Guizhou Province. The age at first birth may be the etiological clue of mild cognitive impairment in rural women aged 70 and above in Guizhou Province, and its causal relationship needs further study. [ABSTRACT FROM AUTHOR]

Menopausal hormone therapy (MHT) is an effective treatment for alleviating menopausal syndrome, and 18.16% of perimenopausal women are receiving MHT treatment at present. Most gynecological malignancies are hormone-dependent, so the safety and efficacy of MHT in women with menopausal syndrome and those women with gynecological malignancies combined with menopausal syndrome are still controversial. For the menopausal syndrome patients without gynecological malignancies, reasonable selection of estrogen therapy may reduce the risk of ovarian cancer, and selection of MHT containing progesterone may reduce the risk of endometrial cancer and cervical cancer. As for epithelial ovarian cancer, early endometrial cancer, cervical squamous cell carcinoma, vaginal squamous cell carcinoma and vulvar squamous cell carcinoma, reasonable selection of MHT regimen may not increase the risk of recurrence, while may prolong the survival. By reviewing the MHT guidelines and the related clinical studies issued globally in recent years, we discuss how to rationally select MHT regimens to reduce the risk of gynecological malignancies in women with menopausal syndrome, how to reduce the recurrence risk of patients with gynecological malignancies combined with menopausal syndrome, and how to improve the survival rate of patients with gynecological malignant tumors. [ABSTRACT FROM AUTHOR]

Objective To investigate the effects of different fertilization methods on embryo quality and clinical outcome in advanced age infertility patients with fewer oocytes retrieved. Methods Clinical data of 706 advanced age infertility patients with fewer oocytes retrieved who underwent in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in our center were retrospectively analyzed. The patients were divided into IVF group (559 cases) and ICSI group (147 cases) according to the fertilization method. The general information, fertilization, embryo quality and clinical outcome were compared between two groups. Results There were no significant differences in female age, body mass index (BMI), anti-mullerian hormone (AMH) and baseline FSH (bFSH) between the two groups (P >0. 05). There were no significant differences in the number of oocytes retrieved, the total fertilization failure rate, normal fertilization rate, 2PN cleavage rate, Transplantable embryo rate, high-quality embryo rate and cycle cancellation rate between the two groups (P >0. 05) . The Mil egg rate in IVF group was significantly higher than that in ICSI group (P <0. 05) . There were no significant differences in the number of embryo transfers, clinical pregnancy rate, implantation rate, early abortion rate, multiple pregnancy rate, ectopic pregnancy rate, live birth rate, birth weight and male female ratio between the two groups (P>0.05). Conclusions ICSI cannot improve the embryo quality and clinical outcome for the advanced age infertility patients with fewer oocytes retrieved. IVF remains the preferred fertilization method. [ABSTRACT FROM AUTHOR]

Polycystic ovary syndrome (PCOS) is one of the most common reproductive endocrine disease in women of reproductive age. It is affected by traditional Chinese culture, fertility concepts, social, economic, family and the disease, PCOS infertility patients often have impaired psychological regulation function, showing more obvious negative emotional characteristics such as depression and anxiety. Negative emotion and disease are causal to each other, they influence each other and form a vicious circle, affecting or aggravating the clinical features, sex hormone level and disorder of glucose and lipid metabolism of PCOS patients, which in turn leads to the occurrence of infertility, and the adverse effects of pregnancy outcomes. The positive psychological intervention and treatment can improve the patients′ psychological state, eliminate or alleviate the negative emotions such as anxiety, thus improve the treatment outcome of PCOS infertility. This article summarizing from the above aspects, is expected to provide new ideas for clinical treatment of patients with PCOS infertility. [ABSTRACT FROM AUTHOR]

Glucose metabolic reprogramming is an important pathophysiological alteration during tumor development. Recent studies have revealed that endometriosis (EMs) has similar reprogramming of glucose metabolism to tumor, namely the transition from mitochondrial oxidative phosphorylation to aerobic glycolysis. Glucose metabolic reprogramming, characterized by increased glucose uptake, increased lactic acid production, and decreased production of reactive oxygen species, is closely associated not only with disease progression of EMs, but also with decreased oocyte quality and impaired endometrial receptivity in patients. This review systematically reviews the research progress of glucose metabolic reprogramming in EMs, providing deeper insight into the pathophysiological mechanism of EMs [ABSTRACT FROM AUTHOR]

N6 -methyladenosine (m6 A) methylation is the most common RNA modification in eukaryotes, which regulates gene expression and biological functions by controlling RNA metabolism, alternative splicing, degradation and translation. In recent years, it has been found that m6 A methylation plays an important regulatory role in the reproductive system, and that m6 A is involved in the occurrence and development of polycystic ovary syndrome, endometriosis, premature ovarian insufficiency, adenomyosis and other female reproductive endocrine diseases and female reproductive system tumors. In addition, m6 A methylation modification can also regulate human spermatogenesis and testicular function, and m6 A is associated with male oligoasthenospermia and male reproductive system tumors. Taken together, m6 A methylation modification may be a new target for the regulation of reproductive-related diseases. In this article, we review the mechanism of m6 A methylation modification and the research progress in reproductive-related diseases, which has certain guiding significance for the diagnosis and treatment of reproductive-related diseases. [ABSTRACT FROM AUTHOR]

Organoids are three-dimensional cellular models cultured in vitro that retain the histological, physiological, and genetic characteristics of original tissues in vivo. They have the advantages of short culture time and high proliferative efficiency. In recent years, organoids have been widely applied in the field of life sciences, particularly in the endometrial research. By overcoming the limitations of conventional cell and animal models, organoids provide a more accurate simulation of the cyclic physiological changes of the endometrium and the characteristics of embryo implantation. Additionally, they show significant potential in disease modeling, precision medicine, drug screening for endometrium -related diseases such as endometriosis, endometrial tumors, and infertility. This review summarizes the progress in the application of organoids in translational research of basic endometrial and related diseases. [ABSTRACT FROM AUTHOR]

There are many kinds of reproductive tract flora, which are symbiotic and antagonistic to each other. They play an important role in defending infection, promoting pregnancy and maintaining a normal intrauterine environment. The metabolites produced by the interaction between the reproductive tract flora and the host are not only related to flora imbalance and host immunity, but also related to adverse pregnancy outcomes. In recent years, the research on the correlation between the role of reproductive tract flora in pregnancy has gradually attracted the attention of the academic community. Therefore, this article attempts to explain the complex interaction between the reproductive tract flora and the host from the aspects of the role of vaginal and cervical flora, uterine cavity flora, fallopian tube and follicular fluid flora in normal pregnancy, as well as the correlation between common microorganisms in the reproductive tract and adverse pregnancy outcomes, in order to provide a basis for studying the mechanism and treatment of adverse pregnancy outcomes. [ABSTRACT FROM AUTHOR]

Background Compared with male adolescents, depression among female adolescents is of higher prevalence and greater severity. The level of generalized trust correlates with the severity of depression, and attachment correlates with the level of generalized trust. Therefore, based on the mediating role of generalized trust between attachment and depression, this study explores the pathogenesis of depression in female adolescents.Objective To explore the mediating role of generalized trust between paternal, maternal and peer attachment and depression in female adolescents, so as to provide references for improving the depression of female adolescents.Methods This study included 73 female adolescents who met the diagnostic criteria for depressive disorder in the International Classification of Diseases, tenth edition（ICD-10） as well as received outpatient and inpatient treatment in Hangzhou Seventh People’s Hospital between March 2022 and October 2022. Investigation was conducted by use of Revised Inventory of Parent and Peer Attachment（IPPA-R）, the Inclusive General Trust Scale（IGTS） and Children’s Depression Inventory（CDI）. Pearson correlation analysis was used to explore the correlation between each scale score. The Bootstrap method was used to test the mediating role of generalized trust between attachment and depression.Results（1） CDI score in female adolescents with depression was negatively correlated with scores of paternal, maternal and peer attachment in IPPA-R（r=-0. 463,-0. 459,-0. 447, P＜0. 01）.Scores of paternal, maternal and peer attachment in IPPA-R were positively correlated with IGTS score（r=0. 372, 0. 318, 0. 395, P＜0. 01）. IGTS score was negatively correlated with CDI score（r=-0. 531, P＜0. 01）.（2） The test of mediating role showed that the direct effect of paternal, maternal and peer attachment on depression level was significant in female adolescents with depression（effect size=-0. 138,-0. 136,-0. 107, 95% CI:-0. 236～-0. 039,-0. 242～-0. 029,-0. 203～-0. 012）.（3）The mediating role of generalized trust between paternal, maternal peer attachment and depression level was significant（effect size=-0. 069,-0. 066,-0. 071, 95% CI:-0. 127～-0. 021,-0. 137～-0. 010,-0. 145～-0. 018）.Conclusion Paternal, maternal and peer attachment can influence the depression level of female adolescents both directly and indirectly through the generalized trust. [ABSTRACT FROM AUTHOR]

ObjectiveTo determine the level of serum 25-hydroxyvitamin D （25（OH）D） and its association with thyroid autoantibodies and thyroid nodules in adult women for health examination in Shanghai.MethodsWe recruited a total of 2 108 healthy women for examination in the hospital. According to the serum 25-hydroxyvitamin D， the women were classified into four groups： 25（OH）D≥30 μg·L-1 as sufficient group， 20 μg·L-1≤25（OH）D

Objective To investigate the effect of narrative nursing on relief of anxiety and depression and improvement of quality of life among young women with breast cancer. Methods Totally 90 young women with breast cancer were randomly divided into the observation group and control group, with 45 cases in each group. All patients received routine care during the treatment, and those in the observation group were given narrative nursing interventions. Patients were evaluated by the Self-rating Anxiety Scale, Self-rating Depression Scale and Functional Assessment of Cancer Therapy-Breast(FACT-B) at hospital admission and 1 month after intervention. Results The SAS and SDS scores decreased in both control group and observation group at one month after intervention, and SAS and SDS scores in the observation group were lower than those in the control group(P＜0. 01). Scores of physiological status, social/family status, emotional status, functional status factors and total score of FACT-B in the observation group were lower than those in the control group (P＜0. 01). Conclusion The narrative nursing is potentially effective to relieve the anxiety and depression of young women with breast cancer, and improve their quality of life. (目的 探讨叙事护理在改善青年女性乳腺癌患者焦虑抑郁及生活质量中的应用效果。方法 选取2021年5月—12月医院肿瘤科收治的青年女性乳腺癌患者90例, 采用随机数字表将患者分为观察组45例和对照组45例。对照组采用常规护理, 观察组在对照组基础上采用叙事护理, 采用焦虑自评量表(SAS)、抑郁自评量表(SDS)和癌症患者生存质量测定量表(FACT-B)分别在患者入院时和干预1个月后进行评定。结果 干预1个月后, 两组SAS评分和SDS评分均较入院时降低, 且观察组SAS评分和SDS评分均低于对照组, 差异有统计学意义(P＜0. 01)。干预1个月后, 观察组患者生理状况、社会与家庭状况、情感状况、功能状况及FACT-B量表总分均低于对照组, 差异有统计学意义(P＜0. 01)。结论 叙事护理能改善青年女性乳腺癌患者焦虑、抑郁情绪, 提升生活质量。)

Objective To identify the risk factors of women with premature coronary artery disease (PCAD) in the Kashgar area, mainly Uyghur residents, providing evidence for effective prevention and treatment of PCAD in this region. Methods Two hundred and forty-four Uighur females in Kashgar area who were hospitalized for coronary angiography (CAG) were enrolled. According to the results of CAG and ages, they were divided into three groups： 69 cases in the control group, 104 cases in the PCAD group, and 71 cases in the late-onset coronary artery disease group. Clinical data were compared among three groups. Univariate and multivariable logistic regression analyses were used to identify the risk factors of PCAD. Results The mean age of onset in the PCAD group was (54.25±6.97) years, and 42.3% of them were admitted due to AMI, accounting for 59.4% in patients with coronary heart disease. Compared with the control group, patients with PCAD had higher prevalence of hypertension and diabetes mellitus, and higher levels of CHOL, TG, APO-B, Hcy and GLU, whereas lower levels of ALB and HGB (all P < 0.05), while compared with the late-onset coronary artery disease group, PCAD group had a lower level of Cys-C, but higher levels of ALB and APO-B, and there was no significant difference in other indicators between two groups (all P > 0.05). Multivariate logistic regression analysis showed that diabetes mellitus [OR = 4.349, 95%CI(1.411, 13.402)], hypertension [OR = 3.121, 95%CI(1.467, 6.639)], APO-B/APO-A1 ratio [OR = 5.603, 95%CI(1.128, 27.838)], Hcy [OR =1.188, 95%CI(1.070, 1.318)] were the independent risk factors of PCAD. Conclusions The onset of coronary heart disease is relatively common in female patients aged < 65 years. Diabetes mellitus, hypertension, high APO-B/APO-A1 ratio and high Hcy level are the independent risk factors for women with PCAD in Kashgar area. Early screening and intervention are needed to prevent PCAD in Kashgar area.

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Objective To understand the health status of female medical staffs in a class 3A hospital of Chongqing City, and to focus on analyzing the prevalence of gynecological diseases and related influencing factors in order to provide the reference information and decision-making basis for relevant units to formulate the health maintenance measures for female medical staffs.Methods The physical examination data of 1 912 female medical staffs participating in the physical examination in a class 3A hospital of Chongqing City during 2021 were classified and sorted, and the influence of the work post, age and education level of the medical staffs on the prevalence of gynecological diseases was analyzed. Results Among 1 912 female medical staffs, the prevalence rate of gynecological diseases was 92.1%（1 761/1 912）.The top five were mammary hyperplasia（87.4%,1 672/1 912）,cervical diseases（38.1%,729/1 912）,breast cysts（9.6%,184/1 912）,uterine fibroids（8.6%,165/1 912） and ovarian cysts（0.6%,11/1 912）.The non-clinical posts, age increase and lower education background were the risk factors of breast hyperplasia.The age increase is a risk factor for cervical diseases. Conclusion The incidence rate of gynecological diseases among female medical staffs is high, which should be paid attention to, and various measures should be taken to promote the health of female medical staff. [ABSTRACT FROM AUTHOR]

Objective: To analyze the characteristics of coronary artery disease, the difference of the clinical efficacy of primary percutaneous coronary intervention (PPCI) treatment and the risk factors of in-hospital death in female patients with acute ST-segment elevation myocardial infarction (STEMI) of different ages. Methods: 408 female patients with STEMI who received PPCI treatment in our hospital from January 2018 to March 2022 were selected, and they were divided into group A (age less than or equal to 65 years, n=161) and group B (age greater than 65 years, n=247) according to the different onset ages. The characteristics of PPCI coronary artery lesions at different onset ages, the differences in clinical efficacy after treatment, and the incidence of in-hospital adverse events were compared. Univariate and multivariate Logistic regression analysis were used to analyze the risk factors of in-hospital mortality in female patients with STEMI. Results: There were significant differences in the number of lesions vessels and calcified lesions between group A and group B (P<0.05). There were no significant differences in the location of lesions vessels, preoperative TIMI blood flow grade, and bifurcation lesions between group A and group B (P>0.05). There was no significant difference in the proportion of intra-aortic pump between the two groups (P>0.05). The time from symptom onset to vessel opening (S-to-D) and portal-balloon dilatation (D-to-B) in the group B were longer than those in the group A (P<0.05). There was no significant difference in the proportion of intraoperative death, stent thrombosis and BARC3-5 bleeding between the two groups (P>0.05). The incidence of postoperative death in the group B was lower than that in the group A (P<0.05). Patients were divided into survival group (n=369) and death group (n=39) according to different prognostic outcomes. Univariate analysis showed that female patients with STEMI of in-hospital death were related to age, diabetes, body mass index (BMI), Killip cardiac function grade, preoperative TIMI blood flow grade, postoperative TIMI blood flow grade, hospitalization days, S-to-D time, D-to-B time, systolic blood pressure (SBP), diastolic blood pressure (DBP), white blood cell count (WBC), neutrophil, platelet volume distribution width (PDW), left ventricular ejection fraction (LVEF) and creatine kinase isoenzyme (CK-MB) (P<0.05). Multivariate Logistic regression analysis showed that older age, lower LVEF, higher CK-MB, postoperative TIMI blood flow grade 0~I, and longer S-to-D time were risk factors for female patients with STEMI of in-hospital death (P<0.05). Conclusion: There are certain differences in the characteristics of coronary artery lesions and the therapeutic efficacy of PPCI in female patients with STEMI of different ages. In addition, older age, lower LVEF, higher CK-MB, postoperative TIMI grade 0~I, and longer S-to-D time are risk factors for female patients with STEMI of in-hospital death [ABSTRACT FROM AUTHOR]

Since the Han Dynasty, the authors of historical records have connected people’s dress and behavior with the concept of Yinyang and Five Elements. They believe that certain clothes and instruments will bring disaster and named them as “Fuyao”. In the literature of the past dynasties, females’ wearing beautiful and delicate dress or men’s wear, or arrogating themselves the right to wear clothes and use instruments, were regarded as demons and a sign of fate changes. The theory of “Fuyao” has not been limited to the category of clothing since it was proposed. The narrator describes the materials, patterns, colors, textures and forms of Fuyao to show its extravagance and charm, providing clues for the understanding of ancient Chinese female clothing from the perspective of social significance. Based on the social context of ancient Chinese ritual culture, this paper analyzes the social significance of the theory of female “Fuyao” recorded in official history, literary sketches and local chronicles from three prospectives. First, the association with disaster is the external condition for historians to judge “Fuyao”. Once a woman’s dress is regarded as “Fuyao”, it is a condemnation of the negative moral connotation of dress. The indoctrination and exhortation of women’s collective consciousness by the literati and officials restricted women’s behavior from the moral level, subjecting women’s aesthetics to political purposes and moral cultivation—while paying attention to their own image, they should pay more attention to the possible influence of their image on others and even the country, and the former must obey the latter. Second, eye-catching attire, including exceptionally beautiful one, is the internal condition for historians to judge “Fuyao”, and the dressing up or behavior that can strongly attract people’s attention may be called “Fuyao”. Clothing was a symbol of social order, and scholar-officials had to control females’ clothing within the rules of etiquette and suppress bizarre clothing. The scholar-officials’ attention to the dress of females indicated that they were highly alert to the possible changes of the social order and social constancy, which was the mission requirement of maintaining the social order. Third, the literati, who received the baptism of Confucian culture, regulated females’ clothing in essence, which was not only the discipline for females, but also the discipline for themselves. Under the influence of the traditional mentality that males and females should keep social distance and the discourse atmosphere that objectified females, the theory of female “Fuyao” reflects not only the discipline for females’ clothes, bodies and thoughts, but also the discipline for sensory pleasure. The article holds that females are the main body of dressing up it judges females’ clothes from the moral point of view with the theory of “Fuyao”, which reflects the discipline of the ancient Chinese social ritual culture on sensory pleasure, and the basic reality of Confucianism and male discourse manipulation. In this way, in addition to aesthetics, this study provides a perspective for the understanding of ancient females’ clothing from the level of social significance. [ABSTRACT FROM AUTHOR]

The International Agency for Research on Cancer (IARC) defines shift work as any arrangement of daily working hours other than the standard daylight hours (typically 7:00/8:00 am–5:00/6:00 pm). To meet the needs of rapid socioeconomic development, shift work is becoming more and more common. The impact of shift work, especially night shift work, on human health cannot be ignored. Female's health is not only important to the well-being of themselves, but also has a far-reaching impact on their children and even their entire family. Increasing epidemiological studies have focused on the effects of night shift work on female's reproductive health. This article reviewed epidemiological evidence of the associations between night shift work and reproductive outcomes, e.g. menstrual cycle, endometriosis, pregnancy rate, adverse pregnancy outcomes, and ovarian cancer. The potential biological mechanisms connecting night shift work to female reproductive health were also introduced, e.g. melatonin regulation, clock gene regulation, and sex hormone regulation. Through this review, we propose to provide a reference for determining occupational risk factors, conducting subsequent relevant studies, and formulating rational health promotion strategies.

Objective To investigate the changes of bone mineral density (BMD) of the lumbar L1-L4 vertebrae before and after menopause and in different body mass indexes (BMI). Methods A total of 1549 cases were reviewed from January 2018 to January 2020 in Chaoyang Hospital, Beijing, using a dual-energy X-ray absorptiometry to measure BMD of L1-L4 vertebrae. The patients were divided into pre-menopausal group and post-menopausal group according to whether they were menopausal or not, and were divided into medium low body recombination group (≤24 kg/m² ) and high body recombination group ( > 24 kg/m² ) according to BMI. Whether there are differences in area BMD ( aBMD) values between and within groups were retrospectively analyzed. Results The aBMD value of lumbar spine L1-L4 in the postmenopausal group was lower than that in the premenopausal group, and the difference among groups was statistically significant. (2) The aBMD values of lumbar spine L1-L4 in the premenopausal group were basically the same, and there was no significant difference among the groups. (3) In the postmenopausal group, the aBMD value of lumbar spine L1 was lower than that of lumbar spine L2-L4, and the aBMD value of lumbar spine L2 was lower than that of lumbar spine L3 and L4. The difference between groups was statistically significant. The aBMD values of lumbar L3 and lumbar L4 were basically the same, and there was no significant difference between the two groups. (4) The aBMD values of low and middle body reconstituted lumbar spine L1-L4 were lower than those of high body reconstituted lumbar spine, and the differences among groups were statistically significant. (5) The aBMD value of lumbar spine L1 was lower than that of lumbar spine L2-L4, and the aBMD value of lumbar spine L2 was lower than that of lumbar spine L3 and L4 in the middle and low body reconstitution. There was a statistically significant difference among the groups. The aBMD values of lumbar L3 and lumbar L4 were basically the same, and there was no significant difference between the two groups. (6) The aBMD values of L1-L4 lumbar vertebrae in high body recombination were basically the same, and the difference was not statistically significant. Conclusion BMD of the lumbar vertebrae in postmenopausal women and women with medium and low weight is relatively low. The risk of osteoporosis and fracture is increased. In addition, BMD of the L1 and L2 lumbar vertebrae in postmenopausal women and middle and low weight women is lower than that of L3 and L4 lumbar vertebrae, and osteoporosis and fracture are more likely to occur. [ABSTRACT FROM AUTHOR]

Objective To investigate the effectiveness and safety of traditional Chinese medicine in the treatment of female overactive bladder (OAB), evidence-based medicine is adopted to analysis and demonstration scientifically and provide evidence for clinical treatment of female OAB.Methods CNKI, CBM, VIP, Wanfang database, PubMed, Embase, and Cochrane Liberary were retrieved by computer, and the randomized controlled trials of traditional Chinese medicine for the treatment of female OAB were included, and data was analyzed by Review Manager 5.3 software.Results A total of 339 literatures were retrieved, and seven randomized controlled trials involving 521 patients with OAB were included.The meta analysis showed that acupuncture combined with traditional Chinese medicine could significantly reduce the frequency of urination [mean difference (MD)=-1.42, 95% confidence interval (95%CI) (-3.48, 0.64), P=0.18] and the frequency of urgent urination [MD=-0.41, 95%CI (-0.59, -0.24), P<0.000 01], improve the quality of female patients life [OABSS score: MD=-0.55, 95%CI (-2.35, 1.25), P=0.55;IPSS score: MD=-1.11, 95%CI (-1.56, -0.67), P<0.000 01], adverse reaction analysis showed that there were fewer adverse reactions caused by OAB in women treated with traditional Chinese medicine [odds ratio=0.57, 95%CI (0.34, 0.96), P=0.03].Conclusion The effect of acupuncture combined with traditional Chinese medicine prescription in the treatment of female OAB is better than that of western medicine alone, and will not increase the incidence of adverse reactions, with high safety. [ABSTRACT FROM AUTHOR]

Objective: To investigate the influencing factors of anxiety state in female patients with in vitro fertilization-embryo transfer (IVF-ET) and its impact on pregnancy outcome. Methods: 192 female patients with IVF-ET who were treated in Department of Reproductive Medicine, Nanjing Gulou Hospital from March 2019 to April 2021 were selected. The anxiety state of all patients was assessed by self-rating anxiety scale (SAS). The clinical data of the patients were collected, Univariate and multivariate Logistic regression analysis were used to analyze influence factors of anxiety in female patients with IVF-ET. The pregnancy outcome of patients with different anxiety state were observed. Results: Among 192 female patients with IVF-ET, 37 (19.27%) patients had anxiety state. There were 15 cases of mild anxiety (40.54%), 10 cases of moderate anxiety (27.03%), and 12 cases of severe anxiety (32.43%). The results of univariate analysis showed that whether anxiety of female patients with IVF-ET were related to family monthly income, failure history of assisted reproductive technology treatment, education level, occupation, infertility years, age, social support, infertility types and causes (P<0.05). Multivariate Logistic regression analysis showed that The infertility type was primary infertility, the infertility cause was female factors, age >34 years, family monthly income <3000 yuan, education level of high school or technical secondary school or below were the risk factors for anxiety state in female patients with IVF-ET (P<0.05). The proportion of optimal embryo, 2PN fertilization, egg harvesting and clinical pregnancy in non-anxiety patients were higher than those in anxiety patients (P<0.05). Conclusion: The female patients with IVF-ET are more prone to have anxiety, and their anxiety is affected by infertility type, infertility cause, age, family monthly income, education level, and anxiety state will also affect the pregnancy outcome of patients. In clinical work, patients with the above influencing factors should be actively psychological counseling. [ABSTRACT FROM AUTHOR]

Objective To investigate the relationship between transverse sinus stenosis and sigmoid sinus anterior wall dehiscence of females. Methods Clinical data of 50 female patients from Jan 2017 to May 2021 in Eye and ENT Hospital were retrospectively analyzed, including 25 cases separately in the sigmoid sinus anterior wall-normal and wall-dehiscence group. Sigmoid sinus anterior wall dehiscence was evaluated by temporal bone high-resolution computerized tomography, and enhanced-MRI (+MRA/V) 3D reconstruction was used to assess if there was transverse sinus stenosis or empty sella, the results were analyzed by χ² test, Fisher’s test or Mann-Whitney U test to find out if there was a difference of the incidence of transverse sinus stenosis between the two groups, and to investigate if cranial sinus characteristics like cranial sinus dominance influence the formation of transverse sinus stenosis. Results The difference in cranial sinus dominance between the sigmoid sinus anterior wall-normal and wall-dehiscence group of females had statistical significance (P=0.001), the incidence of transverse sinus stenosis (χ² =3.571, P=0.114) and empty sella (χ² =4.500, P=0.074) between the two groups tended to the significant value, the cranial sinus dominance proportion along with ipsilateral transverse sinus stenosis has a statistical difference between the two groups (P=0.016). Stratification by cranial sinus dominance revealed that the difference in transverse sinus stenosis between the two groups had no statistical significance (P= 0.149). Conclusion Transverse sinus stenosis was not related to the formation of sigmoid sinus anterior wall dehiscence of females, while cranial sinus dominance was a risk factor for ipsilateral transverse sinus stenosis, and it might be an influential confounding factor affecting the analysis of the correlation between sigmoid sinus anterior wall dehiscence and transverse sinus stenosis. [ABSTRACT FROM AUTHOR]

Traditional Chinese medicine(TCM) is based on the belief that the transformation of qi and blood strength and weakness is the process of human growth and aging, while the disorder of qi and blood is the root of the development of disease. " Women take blood as the basis and qi for use. " Menstruation, pregnancy, birth, and breast milk are based on qi and blood. Postpartum women are often in the states of qi and blood deficiency and blood stasis due to qi deficiency. In older women, the liver blood and kidney essence gradually decline, and qi and blood are also insufficient. According to the characteristics of the population and symptoms of female stress incontinence, it is believed that disorder of qi and blood is the basic pathogenesis of the disease, and the diagnosis should be based on the characterization of qi and blood. It is believed that the disorder of qi and blood in the five organs is the basis of the pathology, while stasis and dampness are important pathological products of the development of female stress incontinence. Therefore, when diagnosing, we should distinguish between the amount of qi and blood strength and the degree of qi stagnation and blood stasis; when treating, we should pay attention to invigorating the spleen and dispersing the stagnated liver qi, benefiting qi to activate blood circulation, and invigorating qi for ascending to restore urinary function. In addition, modern research based on TCM constitution, microscopic syndrome differentiation, and pharmacological analysis provides a scientific basis for the treatment of female stress incontinence by targeting qi and blood. [ABSTRACT FROM AUTHOR]

Objective:To explore the relationship between childhood sexual abuse and aggression in female prisoners,and analyze the mediating role of callous-unemotional traits and the moderating role of selfcontrol.Methods:A total of 254 female prisoners from a female prison were investigated.They were assessed with the Short Form of the Childhood Trauma Questionnaire（CTQ-SF）,Inventory of Callous-Unemotional Traits（ICU）,Self-Control Scale（SCS） and Buss-Perry Aggression Questionnaire（BPAQ）.The hypotheses were tested by the model 4 and model 59 of Process macro for SPSS 25.0,and the bias-corrected bootstrap and Johnson-Neyman method were utilized for mediating and moderating effects analyses.Results:The scores of CTQ-SF,ICU,SCS and BPAQ were respectively（5.6±1.7）,（37.4±6.7）,（57.5±11.2） and（59.0±12.7）.The scores of CSA had a significant direct and positive effect on BPAQ（β=0.17,P <0.01）.The scores of ICU partially mediated the relationship between CSA and BPAQ（β=0.21,0.38,P <0.001）.The direct effect of CSA’s scores on BPAQ and the path from ICU to BPAQ were both moderated by the scores of SCS（B=-0.14,-0.02,P <0.05）.Conclusion:It suggests that childhood sexual abuse not only directly improves the level of aggression in female prisoners,but also improves aggression through the mediator of callous-unemotional traits,and self-control could negatively moderate the direct effect and indirect effect simultaneously. [ABSTRACT FROM AUTHOR]

Objective: To analyze the clinicopathological features, prognostic value and surgical treatment experience in patients with adrenocortical carcinoma with venous tumor thrombus., Methods: We collected relevant data of the patients with adrenocortical carcinoma who had undergone surgery in Peking University Third Hospital from 2018 to 2023. The patients were divided into venous tumor thrombus group and non-tumor thrombus group. The Wilcoxon rank sum test was used to compare the quantitative variables. The chi-squared test and Fisher's exact test were used to compare the categorical variables. The Kaplan-Meier method was used to estimate the survival rate., Results: A total of 27 patients with adrenocortical carcinoma were included, of whom 11 cases (40.7%) had venous tumor thrombus. In the patients with venous tumor thrombus, 8 patients were female and 3 were male. The median age was 49 (36, 58) years. The median body mass index was 26.0 (24.1, 30.4) kg/m 2 . Seven patients presented with symptoms at their initial visit. Six patients had a history of hypertension. Elevated levels of cortisol were observed in 2 cases. Three tumors were found on the left side, while 8 were found on the right side. Median tumor diameter was 9.4 (6.5, 12.5) cm. On the left, there was a case of tumor thrombus limited to the central vein of the left adrenal gland without invasion into the left renal vein, and two cases of tumor thrombus growth extending into the inferior vena cava below the liver. One case of tumor thrombus on the right adrenal central vein did not invade the inferior vena cava. Four cases of tumor thrombus invaded the inferior vena cava below the liver and three cases extended to the posterior of the liver. Ten patients were in European Network for the Study of Adrenal Tumors (ENSAT) stage Ⅲ and one was in ENSAT stage Ⅳ. Open surgery was performed in 6 cases, laparoscopic surgery alone in 4 cases and robot-assisted laparoscopic surgery in 1 case. Two patients underwent ipsilateral kidney resection. Median operative time was 332 (261, 440) min. Median intraoperative bleeding was 900 (700, 2 200) mL. Median hospital stay was 9 (5, 10) days. Median survival time for the patients with tumor thrombus was 24.0 months and median time to recurrence was 7.0 months. The median survival and recurrence time of 16 patients without tumor thrombus were not reached. The patients with tumor thrombus had worse 3-year overall survival (OS) rate (40.9% vs . 71.4%; Log-rank, P =0.038) and 2-year recurrence-free survival (RFS) (9.1% vs .53.7%; Log-rank, P =0.015) rates compared with the patients with non-tumor thrombus., Conclusion: Patients with adrenocortical carcinoma with venous tumor thrombus have poor prognosis. Different adrenal tumor resections and venous tumor thrombus removal procedures based on different tumor thrombus locations are safe and effective in treating this disease.

Objective: To analyze the association between the triglyceride-glucose (TyG) index and the risk of nephrolithiasis across various demographic and clinical subgroups, aiming to enhance early diagnosis and treatment of nephrolithiasis and promote personalized care in diverse populations., Methods: This cross-sectional study analyzed the medical records of 84 968 adults, stratified into three categories (low, middle, high) according to their TyG index scores. To evaluate the association between the TyG index and nephrolithiasis risk, multivariable Logistic regression models were employed, adjusting for potential confounders. Additionally, piecewise linear regression models were used to investigate the non-linear dynamics of the TyG index's relationship with nephrolithiasis risk. Subgroup analyses were performed to explore variations in the effects of the TyG index across different demographic and clinical populations., Results: Increasing TyG index was associated with a higher risk of nephrolithiasis, rising from 4.36% in the low group to 8.96% in the high group ( P < 0.001). In adjusted models, males in the middle and high TyG index categories demonstrated significantly elevated risks of nephrolithiasis, with odds ratios of 1.18 (95% CI : 1.07-1.31, P =0.002) and 1.29 (95% CI : 1.15-1.45, P < 0.001), respectively. Conversely, in females, the association was not statistically significant post-adjustment ( OR =0.98, 95% CI : 0.82-1.16, P =0.778). Among males, for each unit increment in the TyG index below the critical threshold of 8.98, there was a notable 40% escalation in the risk of developing nephrolithiasis ( OR =1.40, 95% CI : 1.24-1.58, P < 0.001). Surpassing this threshold, the TyG index no longer conferred a significant increase in risk ( OR =0.91, 95% CI : 0.78-1.06, P =0.24). Subgroup analyses indicated that this association remained stable regardless of age, BMI, or hypertension status., Conclusion: The TyG index is positively associated with the risk of nephrolithiasis in males, demonstrating a nonlinear dose-response relationship that becomes especially pronounced at certain index levels. This biomarker could potentially serve as a valuable clinical tool for identifying males who are at a high risk of developing nephrolithiasis, thereby enabling targeted preventive strategies. Further research is urgently needed to explore the underlying mechanisms and to verify the applicability of these results across different populations.

Objective: To review and analyze the clinical diagnosis and treatment of renal Ewing's sarcoma with venous tumor embolus, to follow up the survival and prognosis of the patients, and to provide help for the diagnosis and treatment of the disease., Methods: Clinical data (including general data, surgical data and postoperative pathological data) of patients diagnosed with renal Ewing's sarcoma with venous tumor embolus in Peking University Third Hospital from June 2016 to June 2022 were collected, and the prognosis of the patients was followed up to analyze the influence of diagnosis and treatment process on the prognosis of the disease., Results: There were 6 patients, including 1 male and 5 females. There were 4 cases of left renal tumor and 2 cases of right renal tumor. The median age at diagnosis was 28 years (16-52 years). The imaging findings were all exogenous tumors with internal necrotic tissue and hemorrhage. The mean maximum tumor diameter was 12.6 cm, and the mean tumor thrombus length was 7.8 cm. Four patients underwent open surgery and 2 patients underwent laparoscopic surgery. The postoperative pathological results were renal Ewing sarcoma. Immunohistochemical results showed 3 cases of CD99 (+), 2 cases of FLI-1 (+), and 1 case of CD99, FLI-1 (-). 3 patients received chemotherapy (cyclophosphamide, doxorubicin, vincristine/ifosfamide, etoposide), 1 case received chemotherapy combined with radiotherapy, and 2 cases received no adjuvant therapy. The mean overall survival (OS) of the 6 patients was 37 months, and the mean OS of the 4 patients (47 months) who received chemotherapy was significantly higher than that of the 2 patients (16 months) who did not receive chemotherapy ( P =0.031)., Conclusion: Renal Ewing's sarcoma with venous tumor embolus is rare in clinic, and it is common in young female patients. The operation is difficult and the prognosis is poor. Surgical resection, adjuvant radiotherapy and chemotherapy can improve the overall survival rate of the patients.

Objective: To investigate the feasibility, safety and effectiveness of robot-assisted laparoscopic buccal mucosa graft ureteroplasty in the treatment of complex long proximal ureteral stricture., Methods: The clinical data of 20 patients with proximal ureteral stricture undergoing robot-assisted laparoscopic buccal mucosa graft ureteroplasty admitted to the Department of Urology, Peking University First Hospital and Beijing Jiangong Hospital from July 2022 to January 2023 were prospectively collected and analyzed. Intraoperative conditions, postoperative complications and follow-up data were also recorded and analyzed., Results: The operations under robot-assisted laparoscopy were performed successfully in all the 20 patients without conversion to traditional laparoscopic surgery or open surgery. The study included 14 males and 6 females with a mean age of (41±11) years (range: 19 to 60 years) and a mean body mass index of (24.3±3.6) kg/m 2 (range: 18.2 to 31.8 kg/m 2 ). There were 9 cases on the left side and 11 cases on the right side. The strictures of all the patients were located in the proximal segment of the ureter (including the ureteropelvic junction). The mean preoperative serum creatinine was (92.2±23.3) μmol/L (range: 49.2 to 138.9 μmol/L), and the mean length of ureteral stricture was (2.8±0.9) cm (range: 1.0 to 4.0 cm). Ten patients had previously undergone unsuccessful reconstructive surgery. During the operation, 12 patients received posteriorly augmented anastomosis with ventral onlay. The mean length of the buccal mucosa graft harvested during the operation was (3.1±0.6) cm (range: 2.0 to 4.3 cm), and the median width was 1.5 cm (range: 1.0 to 2.0 cm). The omentum flap was used to wrap the reconstructed ureteral segment in all the 20 cases. The median operative time was 154 min (range: 113 to 300 min), and the median estimated blood loss was 45 mL (range: 0 to 100 mL). The median postoperative hospital stay was 4 d (range: 4 to 14 d). The mean postoperative follow-up time was (15.0±1.7) months (range: 12.5 to 17.9 months), and the surgical success rate was 100.0% in this study. After surgery, 11 patients reported mild discomfort at the oral donor site, 2 patients deve-loped urinary tract infection, and no postoperative complications were reported in the other 7 patients. The mean serum creatinine was (90.9±23.9) μmol/L (range: 60.0 to 153.0 μmol/L) six months after surgery., Conclusion: Robot-assisted laparoscopic buccal mucosa graft ureteroplasty for the treatment of complex long proximal ureteral stricture has satisfactory efficacy without severe complications, which has shown good feasibility, safety and effectiveness. However, large sample studies and long-term follow-up are still needed to evaluate its long-term efficacy.