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Copyright of Chinese Journal of Tissue Engineering Research / Zhongguo Zuzhi Gongcheng Yanjiu is the property of Chinese Journal of Tissue Engineering Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Acute-on-chronic liver failure (ACLF) is a group of clinical syndromes related to severe acute liver function damage and multiple organ failure caused by various acute inducing factors on the basis of chronic liver disease. Due to its serious condition, rapid progression and high mortality, it has attracted more and more attention. Recent studies have shown that the pathogenesis of ACLF mainly includes direct injury and immune injury. As the main immune cells in the liver, the immunoregulatory role of liver macrophages in ACLF has been increasingly recognized. Liver macrophages have excellent phenotype conversion function and plasticity characteristics under the influence of epigenetic reprogramming or local microenvironment. This adaptive expression ability can use key mediators to promote the early conversion of anti-inflammatory phenotype to alleviate liver injury. A large number of studies have shown that liver macrophages have a certain potential in reversing the process of ACLF. Therefore, from the perspective of the plasticity characteristics of liver macrophages, this paper expounds the role of liver macrophages in ACLF and the research on the intervention of ACLF disease process, and summarizes its potential significance in the treatment of ACLF. [ABSTRACT FROM AUTHOR]

Sjogren's syndrome is a refractory disease for which TCM demonstrates certain advantages in its treatment. "Prevalent dryness affecting the liver" is a classical theory from Huangdi Neijing (Huangdi's Internal Classic), which has important guiding significance for the treatment of Sjogren's syndrome with TCM. In this paper, the connotation and development of the theory of "prevalent dryness affecting the liver" is comprehensively analyzed in combination with clinical practice. Sjogren's syndrome is closely related to the liver itself, its functions, and the coordination between the liver and other viscera. The liver itself pertains to yin, and it nourishes blood and moistens dryness. The liver's functions pertain to yang, and they help to move body fluids without any sign of dryness. It's also of great significance that the liver and other viscera are well coordinated. In ancient books and modern studies, many clinical manifestations of Sjogren's syndrome, including anxiety and depression, are closely related to the liver. Therefore, the treatment methods based on regulating and soothing the liver are summarized, such as soothing the liver qi, clearing the liver heat and nourishing the liver yin, taking into account all the five zang organs, and dredging the channels and collaterals. Taking the theory of "prevalent dryness affecting the liver" as the breakthrough point, this paper systematically sorts out the onset, pathogenesis, pattern differentiation, and the significance of addressing the liver in the treatment of Sjogren's syndrome to provide reference for clinical practice. [ABSTRACT FROM AUTHOR]

Copyright of Feed Research is the property of Editorial Board of Feed Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Science & Technology of Cereals, Oils & Foods is the property of Science & Technology of Cereals, Oils & Foods Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Asian Journals of Ecotoxicology is the property of Gai Kan Bian Wei Hui and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Modern Food Science & Technology is the property of Editorial Office of Modern Food Science & Technology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Practical Pharmacy & Clinical Remedies is the property of Editorial Department of Practical Pharmacy & Clinical Remedies and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Multiple biliary hamartomas are a benign incidental finding in the liver. They are not easily detected if one has never seen them, and if appropriate imaging tests are unavailable, and also can be challenging to differentiate from other liver lesions based on imaging alone. Thus, this study aimed to expand the radiologist’s digital image library, enabling a quick and precise differential diagnosis. This paper also highlights the importance of thorough radiological assessment and need for a multidisciplinary approach, involving radiologists, hepatologists, and pathologists, to ensure a precise diagnosis. The patient presented at the hospital for a computed tomography scan and an abdominal magnetic resonance imaging recommended by his general practitioner to assess the biliary tree (magnetic resonance cholangiopancreatography), owing to persistent abdominal pain. The patient had never undergone an abdominal magnetic resonance imaging previously; hence, the discovery of hepatic lesions was incidental and unexpected. Magnetic resonance imaging revealed multiple benign lesions in both the hepatic lobes comparable to the Von Meyenburg complex. These lesions are multiple hamartomas and behave differently in all magnetic resonance imaging sequences. Images acquired with different magnetic resonance imaging sequences were carefully examined. Multiple lesions were found scattered throughout the liver; however, the lesions were benign and consistent with the diagnosis of multiple biliary hamartomas. Medical practitioners should examine the presence of multiple biliary hamartomas and consider them in the differential diagnosis when patients present with hepatic abnormalities. This can prevent unnecessary interventions and guide appropriate patient management.

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi is the property of Journal of Clinical Hepatology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Piezoelectrics & Acoustooptics is the property of Piezoelectric & Acoustooptic and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Imaging Science & Photochemistry is the property of Imaging Science & Photochemistry Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objectives] The paper aimed to study the response of cytochrome P450 enzymes of Carassius auratus liver to maduramicin.[Methods] Semi-static poisoning method was used to expose Carassius auratus to 0.112,0.224,0.448 mg·L-1 maduramicin for 28 days,and a cosolvent-control group was set up. On the 7,14,21 and 28 days after exposure,the liver of Carassius auratus was excised and homogenized,and the mRNA expression of cytochrome P450 1A (CYP1A),cytochrome P450 3A (CYP3A),and cytochrome P450 4T (CYP4T) in Carassius auratus were determined by RT-qPCR. Furthermore,the activities of cytochrome P450 (CYP450) enzymes such as 7-ethoxyresorufin-o-deethylase (EROD),aminopyrine-N-demethylase (APND),aniline hydroxylase (AH),erythromycin-N-demethylase (ERND) and NADPH cytochrome C reductase (NCCR),as well as the content of CYP450 in the liver were determined. The incubation system was established to investigate the effects of maduramicin on CYP1A in Carassius auratus liver microsomes in vitro.[Results] The mRNA expression levels of CYP1A,CYP3A and CYP4T were up-regulated by maduramicin to some degree. The content of CYP450 of 0.448 mg·L-1 group was significantly inhibited after 14 days exposure (P<0.05). In addition,the activities of APND and NCCR in the liver were significantly inhibited by 0.224 and 0.448 mg·L-1 maduramicin on day 14 (P<0.05). On days 14 and 21,the activity of EROD in the liver was significantly inhibited by 0.224 and 0.448 mg·L-1 maduramicin (P<0.05). During the exposure period,the activity of ERND was lower in the experimental groups than in the control group. The activity of AH in the test group increased first and then decreased. In vitro liver microsomes incubation system,the inhibitory effect of maduramicin on CYP1A was less than 25%.[Conclusions] Maduramicin has no effect on CYP1A activity of Carassius auratus liver microsomes. The inhibition of ERND activity by maduramicin may not be regulated by the regulation of CYP3A transcription. In addition,ERND is sensitive to maduramicin and can be used as biomarker for maduramicin exposure. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Image & Graphics is the property of Editorial Office of Journal of Image & Graphics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Ｏｂｊｅｃｔｉｖｅｓ]Ｔｈｅ ｐｕｒｐｏｓｅ ｏｆ ｔｈｉｓ ｐａｐｅｒｓ ｗａｓ ｔｏ ｓｔｕｄｙ ｔｈｅ ｅｆｆｅｃｔ ｏｆ ｃｈｒｏｎｉｃ ｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ｅｘｐｏｓｕｒｅ ｏｎ ｇｒｏｗｔｈ ｐｅｒｆｏｒｍａｎｃｅ ａｎｄ ｌｉｖｅｒ ｈｏｍｅｏｓｔａｓｉｓ ｉｎ ｂｒｏｉｌｅｒｓ. [Ｍｅｔｈｏｄｓ]Ｔｈｉｒｔｙ ４９ ｄａｙ-ｏｌｄ ｂｒｏｉｌｅｒｓ ｗｅｒｅ ｒａｎｄｏｍｌｙ ｄｉｖｉｄｅｄ ｉｎｔｏ ｃｏｎｔｒｏｌ ｇｒｏｕｐ ａｎｄ ｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ｇｒｏｕｐ. Ｔｈｅ ｂｒｏｉｌｅｒｓ ｗｅｒｅ ｆｅｄ ｔｈｅ ｓａｍｅ ｄｉｅｔ. Ｔｈｅ ｂｒｏｉｌｅｒｓ ｏｆ ｃｏｎｔｒｏｌ ｇｒｏｕｐ ｗｅｒｅ ｉｎｊｅｃｔｅｄ ｗｉｔｈ １５％(ｖｏｌｕｍｅ ｔｒａｃｔｉｏｎ)ａｌｃｏｈｏｌ ０.４ ｍｇ􀅰ｋｇ-１, ａｎｄ ｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ｇｒｏｕｐ ｂｒｏｉｌｅｒｓ ｗｅｒｅ ｉｎｊｅｃｔｅｄ ｗｉｔｈ ４.０ ｍｇ􀅰ｋｇ-１ ｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ｆｏｒ ７ ｃｏｎｓｅｃｕｔｉｖｅ ｄａｙｓ. Ｂｏｄｙ ｗｅｉｇｈｔ ｗａｓ ｒｅｃｏｒｄｅｄ ａｔ ｔｈｅ ｂｅｇｉｎｎｉｎｇ ａｎｄ ｅｎｄ ｏｆ ｔｈｅ ｅｘｐｅｒｉｍｅｎｔ. Ｔｈｅ ｓｅｒｕｍ ａｎｄ ｔｉｓｓｕｅ ｉｒｏｎ ｍｅｔａｂｏｌｉｓｍ ｐａｒａｍｅｔｅｒｓ, ｄｕｏｄｅｎｕｍ ａｎｄ ｌｉｖｅｒ ｉｒｏｎ ｍｅｔａｂｏｌｉｓｍ-ｒｅｌａｔｅｄ ｇｅｎｅｓ ａｎｄ ｐｒｏｔｅｉｎｓ ｅｘｐｒｅｓｓｉｏｎ ｗｅｒｅ ｄｅｔｅｃｔｅｄ. [ Ｒｅｓｕｌｔｓ] Ｃｏｍｐａｒｅｄ ｗｉｔｈ ｔｈｅ ｃｏｎｔｒｏｌ, ｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ｅｘｐｏｓｕｒｅ ｓｉｇｎｉｆｉｃａｎｔｌｙ ｉｎｈｉｂｉｔｅｄ ｂｒｏｉｌｅｒｓ ｇｒｏｗｔｈ(Ｐ<０.０１), ｉｎｃｒｅａｓｅｄ ｓｅｒｕｍ ｉｒｏｎ, ｔｏｔａｌ ｉｒｏｎ ｂｉｎｄｉｎｇ ｃａｐａｃｉｔｙ, ｕｎｓａｔｕｒａｔｅｄ ｉｒｏｎ ｂｉｎｄｉｎｇ ｃａｐａｃｉｔｙ ａｎｄ ｔｒａｎｓｆｅｒｒｉｎ ｓａｔｕｒａｔｉｏｎ (Ｐ<０.０１)ａｎｄ ｈｅｐａｔｉｃ ｔｒａｎｓｆｅｒｒｉｎ(ＴＦ)ｅｘｐｒｅｓｓｉｏｎ(Ｐ<０.０１), ｂｕｔ ｇｒｅａｔｌｙ ｄｅｃｒｅａｓｅｄ ｈｅｐａｔｉｃ ｉｒｏｎ ｃｏｎｔｅｎｔ(Ｐ<０.０１)ａｎｄ ｌｉｖｅｒ ｔｒａｎｓｆｅｒｒｉｎ ｒｅｃｅｐｔｏｒ １(ＴＦＲ１)ｐｒｏｔｅｉｎ ｅｘｐｒｅｓｓｉｏｎ(Ｐ＝０.０６). [Ｃｏｎｃｌｕｓｉｏｎｓ]Ｃｏｒｔｉｃｏｓｔｅｒｏｎｅ ｅｘｐｏｓｕｒｅ ｉｎｈｉｂｉｔｅｄ ｂｒｏｉｌｅｒｓ ｇｒｏｗｔｈ, ｉｎｃｒｅａｓｅｄ ｓｅｒｕｍ ｉｒｏｎ ｌｅｖｅｌｓ ａｎｄ ｔｏｔａｌ ｉｒｏｎ ｂｉｎｄｉｎｇ ｃａｐａｃｉｔｙ, ａｎｄ ｒｅｄｕｃｅｄ ｈｅｐａｔｉｃ ｉｒｏｎ ｄｅｐｏｓｉｔｉｏｎ. Ｔｈｅ ｈｅｐａｔｉｃ ｉｒｏｎ ｈｏｍｅｏｓｔａｓｉｓ ｉｎｄｕｃｅｄ ｂｙ ｃｈｒｏｎｉｃ ｃｏｒｔｉｃｏｓ- ｔｅｒｏｎｅ ｅｘｐｏｓｕｒｅ ｗａｓ ｃｌｏｓｅｌｙ ｒｅｌａｔｅｄ ｔｏ ｈｉｇｈ ＴＦ ｅｘｐｒｅｓｓｉｏｎ ａｎｄ ｌｏｗ ｅｘｐｒｅｓｓｉｏｎ ｏｆ ＴＦＲ１. [ABSTRACT FROM AUTHOR]

Copyright of Food Research & Development is the property of Food Research & Development Editorial Department and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objective] he aim of this paper was to explore the function of A. davidianus antimicrobial peptide family genes during the infection process of C. freiindii.[Method] qRT-PCR method was employed to analyze the expression response of antibacterial peptide family genes at different time after infection and the expression changes of different tissues and organs.[Result] After 12,24, 36, 48 hours infection, the antibacterial peptide family genes AdCath 1, AdCaih 5 and AdCath 8 were induced in skin, liver and spleen, and the expression levels were higher than that of the control 1 X PBS, especially the difference was significant between 0 and 36 hours. The expression of the three genes in skin and liver was higher than that in spleen. Especially at 36 hours, the expression of AdCath 1 in skin tissue was 92. 35 times that of 1 X PBS; At 48 hours, the expression of AdCath 1 in liver tissue was 52.99 times that of 1 X PBS.[Conclusion] Antimicrobial peptide genes played an important role in the interaction of 4. davidianus diseases. [ABSTRACT FROM AUTHOR]

The related thesis on theory of kidney storing essence in Huangdi Neijing (Yellow Emperor's Internal Classic) and male infertility were discussed combined with clinical practice. Some feelings and experiences are put forward in the paper, including "essence being stored in kidney rather than born in kidney", "although kidney storing essence and its treatment being in liver", "focus on liver should being in line with the five elements", "kidney and essence deficiency being treated considering both spleen and stomach", "spermatogenesis being easy to move and its treatment should considering warm therapies", "peace and spermatogenesis intending to fine-tune", and "expensive being in pattern differentiation and subtle being in modification". The administration rules of formulas and medicinals are summarized in clinical treatment of male infertility. The important role of liver in the theory of kidney storing essence and male infertility is stressed with hope of providing a broader idea for the diagnosis and treatment of infertility. [ABSTRACT FROM AUTHOR]

The pathogenetic mechanisms of Internet addiction, a disease of the modern times, can be analyzed from the perspective of emotions in traditional Chinese medicine, and the symptoms of the disease and those of emotional diseases in Chinese medicine can provide mutual reference to each other. The formation and development of Internet addiction is closely correlated with the liver in TCM.The present paper explored the following four correlations theoretically: the correlation between constitution characteristics of Internet addicts and the physiology and function of the liver in TCM, that between the onset of Internet addiction and the liver governing the free flow of qi, that between the negative emotions of Internet addiction and liver governing emotions, and that between the symptoms of Internet addiction and those of patterns of the liver. The findings of a survey of emotions associated with Internet addiction of college students in Shandong Province were also reported. In "A General Survey of Clinical Medicine" and "A General Survey of Medical Classics" in Chinese Medical Code (electronic version), the bibliometric frequency of the liver governing the free flow of qi was studied. The basic TCM patterns and core clinical manifestations of Internet addiction were also discussed according to literature data mining. In addition, the relation between Internet addiction and liver in TCM was studied from the perspective of clinical practice and medical literature. [ABSTRACT FROM AUTHOR]

Depression is a common clinical mental illness affecting patients’ quality of life. There has been a more systematic understanding of the treatment of depression in Traditional Chinese Medicine. This paper intended to explore the etiology, pathogenesis, syndrome differentiation, treatment and Traditional Chinese Medicine characteristic nursing intervention of depression from the point of traditional Chinese medicine, and reviewed relevant literature, in order to provide useful ideas for clinical treatment. (抑郁症严重影响患者生活质量。祖国医学对抑郁症的相关论治已有较为系统的认识。本文拟从中医的角度探讨抑郁症相关病因病机、辨证论治以及中医特色护理干预措施, 并对相关文献进行总结与探讨, 以期为临床治疗提供有益思路。)

Copyright of Guangdong Agricultural Sciences is the property of South China Agricultural University, Guangdong Academy of Agricultural Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

[Objectives] The aim of the paper is to investigate the effects of soybean isoflavones(SI)on liver injury induced by environmental endocrine disruptor 3-methyl-4-nitrophenol(PNMC)in roosters and its mechanism. [Methods] Forty-eight healthy white roosters(1 day-old)were randomly divided into 3 groups(4 replicates per group and 4 birds per replicate):basal diet group(control group),basal diet+10 mg·L-1 PNMC in water group(PNMC group),basal diet+10 mg·L-1 PNMC in water+100 mg·kg-1 SI in diet group(PNMC+SI group). The trial lasted 42 days and samples were collected on 21 and 42 days,respectively,and the growth performance was recorded. On the final day,livers were sampled and weighed to calculate the liver index. Activities of T-SOD,CAT and contents of MDA,GSH and H2O2 in liver tissues were assessed. In addition,morphological changes of livers were observed using HE staining. [Results] Compared with the control group,body weights in PNMC group decreased on 21 and 42 days(P<0.05);ADG reduced during 22-42 d and 1-42 d;while ADFI and F/G significantly increased during 1-21 d,22-42 d and 1-42 d(P<0.01);liver weight and the content of GSH were significantly lower on 42 days(P<0.05). Compared with PNMC group,final body weight in PNMC+SI group significantly increased(P<0.01);ADG was higher during 1-21 d and 22-42 d;and F/G markedly decreased during 1-21 d,22-42 d and 1-42 d(P<0.01);meanwhile,the GSH content in PNMC+SI group was significantly enhanced on 42 days(P<0.05),while contents of T-SOD,CAT,MDA,H2O2 of livers in PNMC group and PNMC+SI group showed no significant difference compared with those in control group(P>0.05). Multiple hepatocyte necrosis and different degrees of nuclear condensation were observed in PNMC group,while in PNMC+SI group less serious damage was shown similar to the situation of control,alleviating the pathological changes in liver tissues. [Conclusions] These results suggested that SI could attenuate liver injury caused by PNMC,improve growth performance,and increase antioxidant ability in the liver of PNMC exposed roosters. [ABSTRACT FROM AUTHOR]

Objective To summarize the clinical features of optic neuritis (ON) complicated with chronic hepatitis B virus (HBV) infection, and evaluate the effectiveness of different treatment regimens, recurrence of ON, visual prognosis, HBV reactivation, liver function and liver structure changes. Methods and Results Total 19 patients (23 eyes) with acute ON complicated with chronic HBV infection admitted to Beijing Tongren Hospital, Capital Medical University from January 2015 to June 2021 were included. There were 13 females and 6 males, 15 cases with monocular onset, 17 cases with unidirectional course of disease, and 6 cases with optic disc edema. The time to the worst visual acuity (peak time) was 3 (2, 7) d after onset, and 16/23 eyes had severe visual impairment. Enhanced MRI showed abnormal intensity in orbital, intraductal or intracranial segments of optic nerve, even involving optic nerve sheath and optic chiasm. Anti-nuclear antibody (ANA) was positive in 5 cases and A type Sjögren's syndrome antibody (SSA) was weakly positive in one case. Cerebrospinal fluid (CBF) pressure decreased in 1/7 cases and white blood cell count increased in 2/7 cases. HBV DNA positive group (HBV DNA ≥ 100 IU/ml, 10 cases and 11 eyes) had more severe visual impairment than negative group (HBV DNA < 100 IU/ml, 9 cases and 12 eyes), the difference was statistically significant (Fisher's exact probability: P = 0.005, 0.003). HBV DNA positive group was treated with entecavir, and the recurrence of ON was ignored during follow-up. HBV DNA negative group didn't receive antiviral therapy, one case progressed to cirrhosis, 3 cases had abnormal liver function, and 2 cases had HBV reactivation. Conclusions The visual function of patients with ON complicated with chronic HBV infection was seriously impaired, and the response to glucocorticoid therapy was not good. The visual impairment of patients with positive HBV DNA was more serious than patients with negative HBV DNA. Patients with ON complicated with chronic HBV infection should be treated with antiviral drugs in combination with glucocorticoid therapy. [ABSTRACT FROM AUTHOR]

Accurately and efficiently contour extraction for the liver CT image sequence is one of the key problems of the abdominal soft-tissue model reconstruction and visualization. This paper proposed a contour extraction method based on a priori knowledge model. Firstly, it employed the Laplace transformation algorithm for image enhancement, and then proposed lasso model based on a priori knowledge of edges for semi-automatic initialization. Finally, it extracted contours of the liver accurately by an improved Snake algorithm. Furthermore, after the first image extraction, it proposed to initialize other CT images automatically according to the correlation between sequence, i. e. extraction result of previous image was employed as the initialization points of the next image, and so on. In this way, it preformed the whole extraction in a very elegant batch fashion. The experimental results on both liver images and lung images show that the proposed algorithm greatly reduces the dependence on initializing accuracy while effectively solve the problem of the liver contour extraction. [ABSTRACT FROM AUTHOR]

Silymarin is a traditional hepatoprotective herb for the adjuvant therapy of liver diseases, which shows marked pharmacological activities such as antioxidant and anti-inflammatory properties. This paper introduces the action mechanism of silymarin in regulating liver function, ameliorating hepatic fibrosis, protecting pancreatic cells, suppressing the growth of tumor cells, and inhibiting the replication of hepatitis C virus. Silymarin is considered to be a natural medicine with little toxic or side effect at a high dose. It holds promise for anti-tumor, antioxidant, anti-inflammatory, and antiviral application. [ABSTRACT FROM AUTHOR]

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