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慢性皮质酮暴露对肉鸡生长性能及肝脏铁稳态的影响.

Authors :
刘明妮
胡云
方茜
马文强
赵茹茜
Source :
Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao. 2020, Vol. 43 Issue 3, p714-719. 6p.
Publication Year :
2020

Abstract

[Objectives]The purpose of this papers was to study the effect of chronic corticosterone exposure on growth performance and liver homeostasis in broilers. [Methods]Thirty 49 day-old broilers were randomly divided into control group and corticosterone group. The broilers were fed the same diet. The broilers of control group were injected with 15%(volume traction)alcohol 0.4 mg􀅰kg-1, and corticosterone group broilers were injected with 4.0 mg􀅰kg-1 corticosterone for 7 consecutive days. Body weight was recorded at the beginning and end of the experiment. The serum and tissue iron metabolism parameters, duodenum and liver iron metabolism-related genes and proteins expression were detected. [ Results] Compared with the control, corticosterone exposure significantly inhibited broilers growth(P<0.01), increased serum iron, total iron binding capacity, unsaturated iron binding capacity and transferrin saturation (P<0.01)and hepatic transferrin(TF)expression(P<0.01), but greatly decreased hepatic iron content(P<0.01)and liver transferrin receptor 1(TFR1)protein expression(P=0.06). [Conclusions]Corticosterone exposure inhibited broilers growth, increased serum iron levels and total iron binding capacity, and reduced hepatic iron deposition. The hepatic iron homeostasis induced by chronic corticos- terone exposure was closely related to high TF expression and low expression of TFR1. [ABSTRACT FROM AUTHOR]

Details

Language :
Chinese
ISSN :
10002030
Volume :
43
Issue :
3
Database :
Academic Search Index
Journal :
Journal of Nanjing Agricultural University / Nanjuing Nongye Daxue Xuebao
Publication Type :
Academic Journal
Accession number :
144776316
Full Text :
https://doi.org/10.7685/jnau.201907008