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Oxidative stress is closely linked to the decline inof female fertility caused by various factors. Antioxidants, which can counteract oxidative stress. have been increasingly used as adjunctive therapy for women with reduced fertility. However, there are limited clinical studies on whether antioxidants can enhance fertility in women with low reproductive capacity and improve pregnancy outcomes, with inconsistent results and generally low-quality evidence. This paper reviewed the impact of oxidative stress on female fertility and discusses the progress of research on the application of antioxidants in common conditions that lead to reduced female fertility and are closely associated with oxidative stress, such as polycystic ovary syndrome, endometriosis, and unexplained infertility, aiming to provide a reference for clinical treatment. [ABSTRACT FROM AUTHOR]

Digestive tract malignant tumor refers to the general term of malignant tumor occurring in digestive tract, including esophageal cancer, gastric cancer, colorectal cancer, liver cancer and pancreatic cancer. Narrative nursing is a kind of nursing measure developed from narrative medicine with the characteristics of holistic nursing concept and humanistic care. This paper reviwed the application research progress of narrative nursing in clinical nursing of patients with digestive tract malignant tumor, and put forward relevant suggestions, so as to provide basis for follow-up nurses to implement narrative nursing intervention for patients with digestive tract malignant tumor and provided reference for further improvement of narrative nursing intervention. [ABSTRACT FROM AUTHOR]

Asthma is one of the most common chronic diseases in childhood, and its pathogenesis is not yet clear. In recent years, the imbalance of intestinal flora has attracted more and more attention to the occurrence and development of childhood asthma. Traditional Chinese medicine believes that the lung and the large intestine are interrelated, and the occurrence of childhood asthma is closely related to the dysfunction of the lung and the large intestine, while Western medicine believes that the occurrence of childhood asthma is related to various factors. Among them, pulmonary immune imbalance caused by intestinal flora disorder is one of the important causes of its occurrence. This paper discussed the occurrence of childhood asthma by focusing on pulmonary and intestinal pathophysiology, so as to provide new targets or therapeutic ideas for the prevention and treatment of childhood asthma. [ABSTRACT FROM AUTHOR]

Vitamin D is an indispensable fat-soluble vitamin in the human body, mainly in the form of vitamin D2 and vitamin D3,which can be synthesized by the skin and ingested in the diet. Vitamin D deficiency is currently a global public health problem, with approximately one billion people worldwide suffering from vitamin D deficiency, and pregnant women are at high risk. Gestational diabetes mellitus（GDM） refers to normal glucose metabolism before pregnancy, and abnormal glucose tolerance of different degrees occurs for the first time during pregnancy, which is one of the complications of pregnancy. Continuous studies have proved that vitamin D deficiency during pregnancy is closely related to GDM,which can affect glucose balance through various mechanisms, leading to an increased risk of GDM. In addition, GDM increases the incidence of maternal and infant complications such as hyperamniotic fluid, pregnancy-induced hypertension, premature rupture of membranes, premature delivery, macrosomia, low body weight, and teratoma, which threatens maternal and infant health. In recent years, the research on the correlation between vitamin D and GDM has been increasing, and its correlation has been paid more and more attention by more and more scholars. This paper reviewed the research progress on the correlation between vitamin D and GDM. [ABSTRACT FROM AUTHOR]

This paper analyzes the literature on virtual reality (VR) technology interventions for autistic children published from 2014 to 2022. It shows that different VR systems in these studies have improved different symptoms of autism, and points out the feasibility of VR technology interventions for autistic children [ABSTRACT FROM AUTHOR]

Alzheimer′s disease (AD) is a neurodegenerative disease with a hidden onset and complex pathology. The clinical diagnosis of AD has probably developed to the middle or late stage. The relative protein biomarkers in the cerebrospinal fluid can pass through the blood-brain barrier and participate the peripheral circulation in the very early stage of AD. Peripheral blood biomarker detection has the characteristics of convenient collection and minimal trauma, and is expected to become the most promising early screening and follow-up method. However, the traditional immunoassay methods cannot meet the demand for the accurate quantitative analysis of ultra-trace protein biomarkers in peripheral blood. In recent years, the newly developed immunoassay techniques in recent years have been widely applied in the analysis of ultra trace protein biomarkers. The paper reviews the recent research progress and analysis methods of early peripheral blood biomarkers of AD. [ABSTRACT FROM AUTHOR]

Heat shock protein 70(HSP70) is a protein that can inhibit cell protein denaturation or expansion under stress or high temperature. It plays a key role in the expression of inflammatory factors, inhibition of apoptosis, and inhibition of protein aggregation. HSP70 is a protein that can inhibit cell protein denaturation or expansion under stress or high temperature. It plays a key role in the expression of inflammatory factors, inhibition of apoptosis, and inhibition of protein aggregation. This paper expounds the close relationship between heat shock protein 70 and the pathogenesis of lung diseases such as lung cancer, pneumonia, pulmonary tuberculosis and asthma, and provides a new idea for the rapid diagnosis of lung diseases. [ABSTRACT FROM AUTHOR]

A patent foramen ovale(PFO) is a cardiac anatomical abnormality that usually fails to close normally at birth, resulting in the blood flow channel between the left ventricle and the right ventricle still existing. In recent years, a growing number of studies have shown that there is a correlation between PFO and migraine, especially in migraine patients with aura. With the continuous development of interventional techniques in cardiology, interventional closure has become an effective method for the treatment of PFO. Studies have shown that the closure of PFO by using a closure device can reduce the risks associated with patent foramen ovale, such as stroke. More encouragingly, some studies have found that PFO closure may help reduce the frequency and severity of migraine attacks. Anxiety and depression are common mental complications in migraine patients. Percutaneous PFO closure has shown favorable results in alleviating migraine symptoms and improving psychological status and quality of life. This review will also discuss the safety and efficacy of PFO closure, as well as the mechanisms associated with migraine, in order to further explore the clinical advances in this field. Finally, this paper emphasize the necessity of screening and managing the mental health status of patients, and expects that future research can provide more clear guidance for PFO closure in the treatment of migraine. [ABSTRACT FROM AUTHOR]

Post-stroke cognitive impairment （PSCI）, refers to a range of clinical syndromes of cognitive impairment caused by stroke. Although its specific pathogenesis is still unclear, many studies have confirmed that endoplasmic reticulum-mitochondria interaction has become a key hub for intracellular signal transduction and substance metabolism, and its regulation of various biological processes, such as Ca2+ balance, lipid metabolism, mitochondrial dynamics, autophagy, and neuroinflammation, is closely related to the development of PSCI. Therefore, in this paper, we will review the various functions of endoplasmic reticulum-mitochondrial interactions and explore their specific roles in PSCI, in order to discover new therapeutic targets and provide new theoretical basis and references for the development of PSCI-targeted drugs in the future. [ABSTRACT FROM AUTHOR]

The patient-reported outcome measurement information system can help doctors make decisions, promote nursing-patient communication and improve patient compliance, which has been widely used in lung cancer clinical practice in Western countries and has become the most valuable tool for evaluating outcome indicators in lung cancer patients. This paper reviewed the current status of the application of patient-reported outcome measurement information system for lung cancer patients both domestically and internationally, aiming to provide reference for clinical nursing research and improve the quality of life of lung cancer patients. The patient-reported outcome measurement information system still has great development potential in the field of lung cancer in China, and it was expected that more practical explorations to promote its true implementation and development in China. [ABSTRACT FROM AUTHOR]

Osteoporosis (OP) is one of the main problems affecting the health of middle-aged and elderly people, and its most serious complication is osteoporotic fracture (OPF), which also has a high disability and mortality rate. The accurate screening and diagnosis of OP mainly rely on imaging analysis, and the diagnosis result rely on the subjective judgment of doctors. Therefore, the traditional imaging method of OP have certain challenges to the accurate screening, diagnosis and differentiation of OP. The cross-fusion of machine learning (ML) and imaging images effectively improves the diagnostic efficiency of clinicians, while realizing the prediction of unknown diseases (such as OPF). Recently, significant progress has been made in the screening and diagnosis of OP and in the diagnosis and prediction of OPF. This paper will review the recent related studies on ML model-assisted screening and diagnosis of OP based on imaging data, so as to provide new ideas for accurate clinical diagnosis and treatment of OP. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a persistent neurological disorder, its main pathological changes are age spots and neurofibrillary tangles, there is no treatment to prevent its progression currently. Autophagy is an intracellular degradation pathway that maintains cellular homeostasis by removing large insoluble proteins. With the deepening of related studies, it is found that the dysfunction of autophagy is related to the pathological process of AD. Hydrogen sulfide (H2S) can regulate autophagy and play a protective role in AD, but the specific mechanism is not fully understood. This paper reviewed the role of H2S in regulating autophagy in the pathological process of AD in recent years, providing new ideas for the prevention and treatment of AD. [ABSTRACT FROM AUTHOR]

Pericardial effusion is a potentially life-threatening complication after hematopoietic stem cell transplantation (HSCT) in children. The incidence of pericardial effusion in children was 4.4% to 37.8%.The occurrence of pericardial effusion is related to many risk factors such as transplant-related thrombomicroangiopathy, pretreatment drugs, graft-versus-host disease, graft type, immunosuppressant, infection and so on. The treatment of pericardial effusion lacks a unified protocol, mainly focus onsupportive treatment, etiologic treatment and pericardial puncture. his paper reviewed the risk factors and treatment of pericardial effusion after HSCT in recent years, and provided suggestions for improving the early identification, diagnosis and treatment of pericardial effusion after HSCT in children. [ABSTRACT FROM AUTHOR]

Vascular endothelial injury is the initiating factor in atherosclerosis Currently, western medical treatment is ineffective and has many adverse effects. It has been found that flavonoids, the active ingredients of Chinese medicine, can regulate endothelial cell function by reducing inflammation, inhibiting oxidative stress, improving apoptosis and autophagy. They have the advantages of multiple pathways, links and targets in the prevention and treatment of atherosclerosis, and have great potential for development. This paper reviewed the recent studies on the mechanism of flavonoids in improving endothelial injury, and provided reference and theoretical basis to promote the discovery of new drug candidates for vascular endothelial injury and the wide application of flavonoids. [ABSTRACT FROM AUTHOR]

At present, cardiovascular and cerebrovascular diseases are currently one of the chronic diseases with the heaviest disease burden in China. With the gradual aging of China's population, the traditional chronic disease management mode of "disease-centered" can no longer meet the health service needs of current residents. The chronic disease management model based on the concept of "active health" is a new type of "health-centered" chronic disease health management model. This mode has established a closer, more convenient and affordable communication mode between residents and family doctor teams.It saves the time, manpower and economic cost of family doctor team service, and is conducive to improving the quality and efficiency of chronic disease management and residents' health literacy. Taking cardiovascular and cerebrovascular diseases as an example, this paper discusseed the chronic disease management mode and research content based on the concept of "active health" aiming to explore the form and standard of "active health" chronic disease management mode, and provide reference for the promotion of this mode [ABSTRACT FROM AUTHOR]

Acute pulmonary embolism (APE) is one of the common acute and critical cardiovascular diseases. Currently, the methods used to diagnose APE rely on imaging and laboratory tests. The commonly used imaging detection methods are complex, consuming time, inconvenient handling for acute and severe patients and high examination cost. Therefore, exploring a simple, economical and effective evaluation method for acute non-high-risk pulmonary embolism patients has important clinical significance. Immune/inflammatory response plays an important role in the pathogenesis of vascular disease. Representative indicators in blood include neutrophil/lymphocyte ratio, monocyte-related indicators, platelet/lymphocyte ratio, systemic immune/inflammatory index, etc. This paper focused on the value of novel inflammatory markers in predicting the diagnosis and prognosis of APE patients. [ABSTRACT FROM AUTHOR]

BACKGROUND: In cartilage degeneration in osteoarthritis, cytokines and signaling pathways that target chondrocytes play an important role. OBJECTIVE: To review the latest research progress of osteoarthritis related cytokines and signaling pathways in recent years, such as the mechanism of action and treatment modalities, in order to provide a basis for future exploration of new therapeutic targets and modalities. METHODS: Literature search was conducted on CNKI, WanFang, VIP, PubMed, Web of Science, and Medline databases. Chinese search terms were “osteoarthritis, cytokines, signal pathway, chondrocyte, inflammation, treatment”. Finally, 60 papers were included for review. RESULTS AND CONCLUSION: (1) In current studies, it is believed that the specific mechanism of osteoarthritis is not clear, and a large number of studies have shown that osteoarthritis is strongly associated with cytokines and signaling pathways, which is a complex process of action. Relevant studies taking cytokines and signaling pathways as therapeutic breakthroughs are also the current hot spot. (2) The receptor antagonists of pro-inflammatory factors such as interleukin 1 are not effective in the treatment of osteoarthritis, and more studies turn to gene therapy. (3) The therapeutic methods of transforming growth factor β, recombinant factors of Wnt signaling pathway, gene therapy and mesenchymal stem cells have obtained positive research results. However, basic and clinical studies on safety and efficacy are likely to be conducted in future studies. (4) At present, relevant therapeutic methods such as platelet-rich plasma have been widely used in clinical practice, while recombinant factor, gene therapy and mesenchymal stem cell therapy are all in the research stage, among which mesenchymal stem cell therapy and gene therapy are expected to make breakthroughs in the field of cartilage repair and regeneration, and are worthy of expectation in the future. However, more clinical and basic studies are needed to verify its effectiveness and safety, explore its mechanism of action and scope of application, and set standards for its clinical use. [ABSTRACT FROM AUTHOR]

Parkinson′s disease (PD) is a neurodegenerative disease commonly in the elderly, which is mainly characterized by resting tremor, bradykinesia, and muscle tonus. Caenorhabditis elegans has its unique advantages in the study of neurological diseases and is a widely used model organism. The paper briefly summarized the characteristics of the Caenorhabditis elegans model and focuses on the application of Caenorhabditis elegans in the study of PD, which provided reference and options for the study of PD mechanism and the development of new drugs. [ABSTRACT FROM AUTHOR]

BACKGROUND: Currently, electrospun nanofibers, which are biomimetic materials of natural extracellular matrix and contain a three-dimensional network of interconnected pores, have been successfully used as scaffolds for various tissue regeneration, but are still faced with the challenge of extending the biomaterials into three-dimensional structures to reproduce the physiological, chemical as well as mechanical properties of the tissue microenvironment. OBJECTIVE: To summarize the process and principles of electrostatic spinning and to explore the applications of the resulting electrospun nanofibers in tissue regeneration of skin, blood vessels, nerves, bone, cartilage and tendons/ligaments. METHODS: With “electrospinning, electrospun nanofibers, electrospun nanofiber scaffolds, tissue regeneration” as the Chinese and English search terms, Google Academic Database, PubMed, and CNKI were searched, and finally 88 articles were included for review. RESULTS AND CONCLUSION: (1) The electrospun nanofibers are a natural fibrous extracellular matrix mimetic material and contain a three-dimensional network of interconnected pores that have been successfully used as scaffolds for a variety of tissue regeneration applications. (2) Several papers have described the great potential of electrospun nanofiber scaffolds applied to the regeneration of skin, blood vessels, nerves, bones, cartilage and tendons/ ligaments, providing a solid theoretical basis for its final application in clinical disease treatment, or for its transformation into practical products to enter the market. (3) However, the current research results are mostly based on cell experimental research results in vitro, and whether it can be finally applied to human body still needs clinical verification. (4) At present, many kinds of electrospun products for various clinical needs have been commercialized in and outside China, indicating that the research field of electrospun nanofiber scaffolds for soft and hard tissue regeneration has great research value and application potential. [ABSTRACT FROM AUTHOR]

Every link in the occurrence and development of malignant tumors is closely related to immune regulation. In recent years, the research of Ferroptosis and the killing of tumor cells by PD-1/PD-L1 inhibitors is a hot spot. Because of the effect of its precise treatment of tumors, it has been more and more applied in clinical treatment. However, there is still no study on the combination of PD-1/PD-L1 inhibitors and Ferroptosis treatment of tumor cells. In this paper, mechanism of Ferroptosis, relationship between Ferroptosis and tumor, and PD-1/PD-L1 immunotherapy of tumor are reviewed. [ABSTRACT FROM AUTHOR]

Refeeding syndrome (RFS) is a series of life-threatening clinical symptoms caused by abnormal metabolism in the early stage of re-intake of nutrition in the patients with chronic malnutrition. Due to the lack of specificity it is difficult to identify, and has higher mortality in ICU patients. At present, there are few studies on the management and prognosis of RFS by domestic scholars, moreover the specific management measures are still controversial. In addition, there are also differences in the methods and conclusions of RFS prognostic studies. Thus this paper systematically reviews the diagnostic criteria, occurrence status, management status and disease prognosis of RFS, aiming at offering the experience to medical staffs on RFS management and providing reference for follow-up related research. [ABSTRACT FROM AUTHOR]

Anterior cruciate ligament (ACL) injury of knee joint is a common sports injury, which can lead to instability of knee joint, reduce the movement ability of the patients, and affect the quality of life of the patients. This paper reviews the anatomy, injury risk factors, imaging findings and treatment of the anterior cruciate ligament of the knee aiming to provide further understanding for clinical prevention and treatment of anterior cruciate ligament injury. [ABSTRACT FROM AUTHOR]

This paper aims to review treatment delay in first-episode schizophrenia, depression, and bipolar disorder, and to compare related factors of treatment delay in the three first-episode mental disorders. It is found that increased patient responsibility, stigma, lack of disease-related knowledge, lack of access to resources, and insufficient medical support lead to delay treatment, and making patients to have longer course, heavier symptoms, and lower social functions. [ABSTRACT FROM AUTHOR]