1. Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins
- Author
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Chih-Wen Shu, Yao-Dung Hsieh, Huei-Cin Sie, Ting-Ying Fu, Liang-Ming Yen, Yaoh-Shiang Lin, Yun-Chung Lin, Yi-Min Wu, Pei-Feng Liu, Bor-Hwang Kang, Luo-Ping Ger, Ju-Hsin Sun, I-Chien Hsieh, Huei-Han Liou, and Yu-Kai Tseng
- Subjects
Male ,0301 basic medicine ,Carcinogenesis ,Cellular differentiation ,lcsh:Medicine ,Vimentin ,Pathology and Laboratory Medicine ,medicine.disease_cause ,Biochemistry ,Metastasis ,Cytopathology ,0302 clinical medicine ,Basic Cancer Research ,Medicine and Health Sciences ,lcsh:Science ,Multidisciplinary ,Tissue microarray ,biology ,Nuclear Proteins ,Cell Differentiation ,Middle Aged ,Cadherins ,Prognosis ,Tongue Neoplasms ,Oncology ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Immunohistochemistry ,Female ,Anatomy ,Research Article ,Adult ,Epithelial-Mesenchymal Transition ,Lymphatic System ,03 medical and health sciences ,Biomarkers, Tumor ,Carcinoma ,medicine ,Humans ,Epithelial–mesenchymal transition ,Twist-Related Protein 1 ,lcsh:R ,Biology and Life Sciences ,Proteins ,medicine.disease ,Cytoskeletal Proteins ,030104 developmental biology ,Anatomical Pathology ,biology.protein ,Cancer research ,lcsh:Q ,Snail Family Transcription Factors ,Lymph Nodes ,Biomarkers ,Developmental Biology - Abstract
We aimed to investigate the association of the expression levels of five epithelial–mesenchymal transition (EMT)-related proteins (Snail, Twist, E-cadherin, N-cadherin, and Vimentin) with tumorigenesis, pathologic parameters and prognosis in tongue squamous cell carcinoma (TSCC) patients by immunohistochemistry of tissue microarray. The expression levels of Snail, E-cadherin, N-cadherin and Vimentin were significantly different between the tumor adjacent normal and tumor tissues. In tumor tissues, lower E-cadherin and higher N-cadherin levels were associated with a higher grade of cell differentiation, advanced stage of disease, and lymph node metastasis. However, higher Vimentin expression was associated with poor cell differentiation and lymph node metastasis. Patients with low E-cadherin expression had poor disease-specific survival (DSS). Conversely, positive N-cadherin and higher Vimentin expression levels were associated with poor DSS and disease-free survival. Notably, our multivariate Cox regression model indicated that high Vimentin expression was an adverse prognostic factor for DSS in TSCC patients, even after the adjustment for cell differentiation, pathological stage, and expression levels of Snail, Twist, E-cadherin, and N-cadherin. Snail, E-cadherin, N-cadherin, and Vimentin were associated with tumorigenesis and pathological outcomes. Among the five EMT-related proteins, Vimentin was a potential prognostic factor for TSCC patients.
- Published
- 2017