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Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins
- Source :
- PLoS ONE, Vol 12, Iss 6, p e0178581 (2017), PLoS ONE
- Publication Year :
- 2017
- Publisher :
- Public Library of Science (PLoS), 2017.
-
Abstract
- We aimed to investigate the association of the expression levels of five epithelial–mesenchymal transition (EMT)-related proteins (Snail, Twist, E-cadherin, N-cadherin, and Vimentin) with tumorigenesis, pathologic parameters and prognosis in tongue squamous cell carcinoma (TSCC) patients by immunohistochemistry of tissue microarray. The expression levels of Snail, E-cadherin, N-cadherin and Vimentin were significantly different between the tumor adjacent normal and tumor tissues. In tumor tissues, lower E-cadherin and higher N-cadherin levels were associated with a higher grade of cell differentiation, advanced stage of disease, and lymph node metastasis. However, higher Vimentin expression was associated with poor cell differentiation and lymph node metastasis. Patients with low E-cadherin expression had poor disease-specific survival (DSS). Conversely, positive N-cadherin and higher Vimentin expression levels were associated with poor DSS and disease-free survival. Notably, our multivariate Cox regression model indicated that high Vimentin expression was an adverse prognostic factor for DSS in TSCC patients, even after the adjustment for cell differentiation, pathological stage, and expression levels of Snail, Twist, E-cadherin, and N-cadherin. Snail, E-cadherin, N-cadherin, and Vimentin were associated with tumorigenesis and pathological outcomes. Among the five EMT-related proteins, Vimentin was a potential prognostic factor for TSCC patients.
- Subjects :
- Male
0301 basic medicine
Carcinogenesis
Cellular differentiation
lcsh:Medicine
Vimentin
Pathology and Laboratory Medicine
medicine.disease_cause
Biochemistry
Metastasis
Cytopathology
0302 clinical medicine
Basic Cancer Research
Medicine and Health Sciences
lcsh:Science
Multidisciplinary
Tissue microarray
biology
Nuclear Proteins
Cell Differentiation
Middle Aged
Cadherins
Prognosis
Tongue Neoplasms
Oncology
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Immunohistochemistry
Female
Anatomy
Research Article
Adult
Epithelial-Mesenchymal Transition
Lymphatic System
03 medical and health sciences
Biomarkers, Tumor
Carcinoma
medicine
Humans
Epithelial–mesenchymal transition
Twist-Related Protein 1
lcsh:R
Biology and Life Sciences
Proteins
medicine.disease
Cytoskeletal Proteins
030104 developmental biology
Anatomical Pathology
biology.protein
Cancer research
lcsh:Q
Snail Family Transcription Factors
Lymph Nodes
Biomarkers
Developmental Biology
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....ec3defcb90c807513858cb9499a631ea