1. The development of the MCH system
- Author
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K. Legagneux, B. Griffond, Sophie Croizier, Dominique Fellmann, F. Brischoux, Pierre-Yves Risold, Estrogènes, Expression génique et pathologies du Système Nerveux Central - UFC (E2SNC / ESTROGENES), Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)
- Subjects
MESH: Cell Differentiation ,Melanin-concentrating hormone ,Physiology ,Cellular differentiation ,Central nervous system ,MESH: Neurons ,Biology ,Biochemistry ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,MESH: Melanins ,Hypothalamic Hormones ,medicine ,Animals ,Humans ,MESH: Animals ,[SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology ,030304 developmental biology ,Melanins ,Neurons ,0303 health sciences ,MESH: Humans ,Neurogenesis ,Cell Differentiation ,respiratory system ,Phenotype ,MESH: Hypothalamic Hormones ,Pituitary Hormones ,medicine.anatomical_structure ,MESH: Pituitary Hormones ,chemistry ,Hypothalamus ,Birth date ,Neuroscience ,hormones, hormone substitutes, and hormone antagonists ,030217 neurology & neurosurgery - Abstract
International audience; Although a great deal is published on the MCH neurons, very few works were devoted to the study of their development. However, existing literature points out two important traits: first, these neurons differentiate a MCH phenotype very early in all species studied so far, which might suggest a role for the MCH peptide during development; second, in the rat, birth date greatly influence the phenotype of MCH neurons. At least two sub-populations were described on the basis of their chemical phenotype, projection pattern and birth date. The understanding of processes involved in the differentiation of these sub-populations may help understand the medio-lateral differentiation of the tuberal hypothalamus.
- Published
- 2009