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Your search keyword '"Manmohan Reddy Leleti"' showing total 2 results
Start Over Author "Manmohan Reddy Leleti" Journal organic process research & development
2 results on '"Manmohan Reddy Leleti"'

1. Development of a Scalable Method for Manufacturing the Central Core of CD73 Inhibitor AB680

Author

Manmohan Reddy Leleti, Jeremy Fournier, Steven D. Jacob, Eric F. Connor, Grange Rebecca Louise, Kenneth V. Lawson, Anh Tran, Jaroslaw Kalisiak, Jay P. Powers, and Xuelei Yan

Subjects
Computer science, Pancreatic cancer, Organic Chemistry, Core (graph theory), medicine, Computational biology, Physical and Theoretical Chemistry, medicine.disease, Small molecule
Abstract

AB680 is a highly potent CD73 small molecule inhibitor discovered and developed by Arcus Biosciences, currently in clinical trials for the treatment of pancreatic cancer. Here, we report the develo...

Published
2020
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2. Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2b Receptor Antagonist

Author

Jenna L. Jeffrey, Laurent Debien, Dillon H. Miles, Manmohan Reddy Leleti, Brandon Reid Rosen, Jay P. Powers, and Ehesan U. Sharif

Subjects
Chemistry, medicine.drug_class, Organic Chemistry, Convergent synthesis, medicine, Antagonist, Physical and Theoretical Chemistry, DUAL (cognitive architecture), Pharmacology, Receptor, Receptor antagonist
Abstract

AB928 is a potent and selective dual antagonist of the A2a and A2b receptors, which is currently in clinical trials. Here, we report the development of two scalable and practical syntheses of AB928...

Published
2020
Full Text
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