Development of a Scalable Method for Manufacturing the Central Core of CD73 Inhibitor AB680

Authors :: Manmohan Reddy Leleti
Jeremy Fournier
Steven D. Jacob
Eric F. Connor
Grange Rebecca Louise
Kenneth V. Lawson
Anh Tran
Jaroslaw Kalisiak
Jay P. Powers
Xuelei Yan
Source :: Organic Process Research & Development. 25:157-162
Publication Year :: 2020
Publisher :: American Chemical Society (ACS), 2020.
Abstract: AB680 is a highly potent CD73 small molecule inhibitor discovered and developed by Arcus Biosciences, currently in clinical trials for the treatment of pancreatic cancer. Here, we report the develo...

Subjects :: Computer science
Pancreatic cancer
Organic Chemistry
Core (graph theory)
medicine
Computational biology
Physical and Theoretical Chemistry
medicine.disease
Small molecule

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