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Development of a Scalable and Practical Synthesis of AB928, a Dual A2a/A2b Receptor Antagonist

Authors :
Jenna L. Jeffrey
Laurent Debien
Dillon H. Miles
Manmohan Reddy Leleti
Brandon Reid Rosen
Jay P. Powers
Ehesan U. Sharif
Source :
Organic Process Research & Development. 24:1254-1261
Publication Year :
2020
Publisher :
American Chemical Society (ACS), 2020.

Abstract

AB928 is a potent and selective dual antagonist of the A2a and A2b receptors, which is currently in clinical trials. Here, we report the development of two scalable and practical syntheses of AB928...

Details

ISSN :
1520586X and 10836160
Volume :
24
Database :
OpenAIRE
Journal :
Organic Process Research & Development
Accession number :
edsair.doi...........89f6c9ebef3f0788b33a57e7900a3115
Full Text :
https://doi.org/10.1021/acs.oprd.0c00124