1. Mild Amide N‑Arylation Enabled by Nickel-Photoredox Catalysis
- Author
-
Bradley, Robert D and Bahamonde, Ana
- Subjects
Amides ,Amino Acids ,Biological Products ,Catalysis ,Nickel ,Phenols ,Photochemical Processes ,Chemical Sciences ,Organic Chemistry - Abstract
This paper describes a mild strategy to promote amide arylations. Photoinduced oxidation of a Ni(II) aryl amido intermediate is proposed to facilitate the challenging C-N reductive elimination step at moderate temperatures. Notably, the mildly basic conditions employed facilitate access to a broad scope including protected amino acids, heterocycles, phenols, and sterically hindered substituents. Hence, this work presents an attractive strategy to enable late-stage functionalization of pre-existing amide moieties in commercial drugs and natural products.
- Published
- 2022