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Your search keyword '"Lijian Wang"' showing total 4 results
Start Over Author "Lijian Wang" Journal macromolecular bioscience
4 results on '"Lijian Wang"'

1. Behavior of Endothelial Cells Regulated by a Dynamically Changed Microenvironment of Biodegradable PLLA-PC

Author

Zhi Qiu, Suming Li, Lijian Wang, Yuanwei Chen, Niancao Chen, Changxiu Wan, and Xianglin Luo

Subjects
Polymers and Plastics, Biocompatibility, Chemistry, Cell growth, Phosphorylcholine, 0206 medical engineering, Bioengineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Biomaterials, Endothelial stem cell, Membrane, Tissue engineering, Biochemistry, Materials Chemistry, Biophysics, 0210 nano-technology, Cytotoxicity, Cell adhesion, Biotechnology
Abstract

The influence of PLLA-PC membranes on the behavior of vascular ECs is studied. It was found that the membranes were not cytotoxic. The cell adhesion and spread on PLLA-PC 30/1 were initially depressed. After 1 d, however, cells attached and spread on the copolymer, and proliferated beyond 2 d. To elucidate the mechanism of this behavior, the surface morphology and the degradation products of the PLLA/PC 30/1 membrane during the culture period were tested, and Fg adsorption to the membranes was examined. It is concluded that the behavior of ECs can be regulated by a dynamically changed microenvironment of the PLLA-PC membrane. PLLA-PC copolymers might therefore serve as a novel material for tissue engineering.

Published
2008

2. Behavior of endothelial cells regulated by a dynamically changed microenvironment of biodegradable PLLA-PC

Author

Yuanwei, Chen, Niancao, Chen, Zhi, Qiu, Lijian, Wang, Changxiu, Wan, Xianglin, Luo, and Suming, Li

Subjects
Molecular Structure, Polymers, Surface Properties, Polyesters, Materials Testing, Cell Adhesion, Endothelial Cells, Fibrinogen, Humans, Biocompatible Materials, Lactic Acid, Environment, Cells, Cultured
Abstract

The influence of PLLA-PC membranes on the behavior of vascular ECs is studied. It was found that the membranes were not cytotoxic. The cell adhesion and spread on PLLA-PC 30/1 were initially depressed. After 1 d, however, cells attached and spread on the copolymer, and proliferated beyond 2 d. To elucidate the mechanism of this behavior, the surface morphology and the degradation products of the PLLA/PC 30/1 membrane during the culture period were tested, and Fg adsorption to the membranes was examined. It is concluded that the behavior of ECs can be regulated by a dynamically changed microenvironment of the PLLA-PC membrane. PLLA-PC copolymers might therefore serve as a novel material for tissue engineering.

Published
2009

3. Biodegradable heparin-loaded microspheres: carrier molecular composition and microsphere structure

Author

Juan Luo, Bin He, Xianglin Luo, Di Qiu, and Lijian Wang

Subjects
Materials science, Morphology (linguistics), Magnetic Resonance Spectroscopy, Polymers and Plastics, Surface Properties, Bioengineering, Biocompatible Materials, Polyethylene Glycols, Biomaterials, Polymer chemistry, Amphiphile, PEG ratio, Materials Testing, Materials Chemistry, Microparticle, Particle Size, chemistry.chemical_classification, Drug Carriers, Molecular Structure, Heparin, technology, industry, and agriculture, Anticoagulants, Polymer, Controlled release, Microspheres, Biodegradation, Environmental, Chemical engineering, chemistry, Lactates, Microscopy, Electron, Scanning, Particle size, Drug carrier, Biotechnology
Abstract

Microspheres of amphiphilic triblock polymers PLLA-PEG-PLLA were investigated as carriers for heparin delivery. Two series of PLLA-PEG-PLLA triblock were synthesized and prepared into microspheres with heparin loaded. The microspheres were hollow and the surface morphology varied from smooth to porous. The pore size increased with increasing PEG content. The microsphere size distribution showed that higher PEG content increased the average microsphere size. The release rate of heparin was closely related to the surface morphology of the microspheres. DSC spectra showed that both cold crystalline temperature (Tc) and crystalline melting temperature (Tm) of heparin-loaded microspheres were related to the copolymer composition and the Tc was lower than those of corresponding pure microspheres. [IMAGES: SEE TEXT]

Published
2006

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