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Biodegradable heparin-loaded microspheres: carrier molecular composition and microsphere structure
- Source :
- Macromolecular bioscience. 6(5)
- Publication Year :
- 2006
-
Abstract
- Microspheres of amphiphilic triblock polymers PLLA-PEG-PLLA were investigated as carriers for heparin delivery. Two series of PLLA-PEG-PLLA triblock were synthesized and prepared into microspheres with heparin loaded. The microspheres were hollow and the surface morphology varied from smooth to porous. The pore size increased with increasing PEG content. The microsphere size distribution showed that higher PEG content increased the average microsphere size. The release rate of heparin was closely related to the surface morphology of the microspheres. DSC spectra showed that both cold crystalline temperature (Tc) and crystalline melting temperature (Tm) of heparin-loaded microspheres were related to the copolymer composition and the Tc was lower than those of corresponding pure microspheres. [IMAGES: SEE TEXT]
- Subjects :
- Materials science
Morphology (linguistics)
Magnetic Resonance Spectroscopy
Polymers and Plastics
Surface Properties
Bioengineering
Biocompatible Materials
Polyethylene Glycols
Biomaterials
Polymer chemistry
Amphiphile
PEG ratio
Materials Testing
Materials Chemistry
Microparticle
Particle Size
chemistry.chemical_classification
Drug Carriers
Molecular Structure
Heparin
technology, industry, and agriculture
Anticoagulants
Polymer
Controlled release
Microspheres
Biodegradation, Environmental
Chemical engineering
chemistry
Lactates
Microscopy, Electron, Scanning
Particle size
Drug carrier
Biotechnology
Subjects
Details
- ISSN :
- 16165187
- Volume :
- 6
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Macromolecular bioscience
- Accession number :
- edsair.doi.dedup.....f8b025124a2908c8889fa30585fe7c91