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Researchers from University Hospital Augsburg in Germany have developed a whole blood assay with dual co-stimulation for analyzing host immunity to fungal and viral pathogens. This new method aims to improve sample processing efficiency and reduce the need for large blood volumes typically required for antigen-specific immunoassays. The protocol includes guidance for stimulation tubes preparation, blood stimulation, and downstream sample processing for flow cytometry, cytokine secretion assays, and transcriptional analyses, making T-cell monitoring more accessible for pediatric patients and small animal studies. The research provides a versatile toolbox for complex antigen-specific immune analysis in clinical and translational research settings. [Extracted from the article]

Researchers from the University of Augsburg in Germany have published a report on atopic dermatitis (AD) in the journal Allergy. The report discusses the 4th Davos Declaration, which was developed during the Global Allergy Forum in Davos. The declaration aims to improve the care of patients with AD by uniting experts and stakeholders and addressing the challenges in research, treatment, and management of the condition. The report emphasizes the need for a holistic approach that combines research, education, and clinical application to improve patient outcomes. [Extracted from the article]

A study conducted by the University of Augsburg in Germany aimed to assess the prevalence of systemic autoantibodies in the general Bavarian adult population. The researchers analyzed blood samples from 331 participants and found that 29.9% of them tested positive for at least one screening test, while 42.3% were seropositive for at least one specific autoantibody. The most commonly found autoantibodies were rheumatoid factor, ss2-glycoprotein 1 IgM, and cardiolipin IgG. The study concluded that systemic autoantibodies are common in the Bavarian population and are largely independent of factors such as sex, age, BMI, education, and smoking status. The findings may provide guidance to clinicians regarding the occurrence of autoantibodies in the population, even in the absence of clinical symptoms. [Extracted from the article]