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Researchers from Shandong University in Jinan, China, conducted a study on Fusobacterium nucleatum, a bacterium associated with dental plaques. They evaluated the effectiveness of bioactive compounds from Salvadora persica (chewing stick) against this bacterium using in-silico methods. The study found promising results, suggesting that these compounds could be used as an alternative therapy for managing Fusobacterium nucleatum-related oral diseases. Financial support for the research came from Princess Nourah bint Abdulrahman University. [Extracted from the article]

Researchers from Shandong University in Jinan, People's Republic of China, have developed a new method for synthesizing multifunctional organic fluorescent imidates. This method offers advantages such as operational simplicity, mild reaction conditions, and high yields. The research highlights the potential applications of these imidates in living cells, particularly in targeting the endoplasmic reticulum. This study has been peer-reviewed and provides valuable insights into the field of organic chemistry. [Extracted from the article]

A recent study from Shandong Jianzhu University in Jinan, People's Republic of China, focused on the application of activated carbon-immobilized laccase for degrading tetracycline in wastewater. The research highlighted the effectiveness of this enzymatic degradation method, showcasing high removal rates of tetracycline using the Laccase@AC system. The study emphasized the potential of immobilized laccase as a biocatalyzer for treating antibiotic-contaminated wastewater, offering a cost-effective and eco-friendly solution. [Extracted from the article]

Researchers at QILU University of Technology in Jinan, China, have isolated new secondary metabolites from Penicillium christenseniae SD.84, including two quinolone alkaloid enantiomers. These compounds showed antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus. The study highlights the potential of Penicillium sp. as a source of new antimicrobial agents, contributing to the fight against drug-resistant bacteria. The research has been peer-reviewed and published in Natural Product Research. [Extracted from the article]

Researchers at Shandong Cancer Hospital and Institute in Jinan, China, have found that the combination of fluconazole with natural compounds shows promise in managing resistant Candida albicans infections. Candida albicans is a pathogenic fungus responsible for many invasive fungal infections, and its resistance to fluconazole poses a significant challenge. The study identified 48 natural antifungal compounds that, when combined with fluconazole, exhibit synergistic effects against Candida albicans, offering new therapeutic options and insights into reversing resistance. This research has been peer-reviewed and provides valuable information for combating fungal infections. [Extracted from the article]

Researchers at Shandong University in Jinan, China, have developed a novel sodium alginate composite hydrogel with a dual cross-linking mechanism for creating adhesive microneedle patches. This new technology addresses issues with conventional microneedle patches by improving surface morphology and mechanical properties, resulting in better drug delivery efficacy and mechanical robustness. The microneedle patch demonstrated excellent water adhesion and efficient drug release within 15 minutes, showing promise for transdermal drug delivery and reducing the workload of healthcare professionals. The study has been peer-reviewed and published in Colloids and Surfaces A Physicochemical and Engineering Aspects. [Extracted from the article]

Researchers from Shandong Cancer Hospital and Institute in Jinan, China, have explored the use of Rehmapicroside (Reh) in combination with cisplatin (cDDP) to enhance the effectiveness of chemotherapy in hepatocellular carcinoma (HCC) treatment. Their study showed that the combined treatment reduced cell proliferation, induced cell cycle arrest and apoptosis, and suppressed tumor growth in HCC cells. The researchers found that Reh and cDDP co-treatment inhibited the TRIM21-PI3K/AKT signaling pathway, leading to decreased cell proliferation, migration, and invasion. This research suggests that the combination therapy of Reh and cDDP could be a promising strategy for HCC treatment. [Extracted from the article]

Researchers from Shandong Normal University in Jinan, People's Republic of China, have developed a new hydrophobic surface-enhanced Raman scattering (SERS) strategy using superhydrophobic ZnO/Ag nanowires to monitor trace antibiotics in harsh water environments. This innovative approach concentrates dispersed molecules in water and enhances the electric field, improving detection sensitivity and anti-interference capabilities. The study demonstrates the potential application of this platform in various real-time detection scenarios, such as monitoring antibiotics in corrosive urine and flowing wastewater. The research, published in ENERGY & ENVIRONMENTAL MATERIALS, highlights the synergistic enhancement of in situ SERS performance under aqueous conditions and offers insights for improving analytical techniques. [Extracted from the article]

Researchers at Shandong University in Jinan, China, have found that the level of nicotinamide adenine dinucleotide (NAD+) is decreased in the plasma and CD4+ T cells of patients with immune thrombocytopenia (ITP). By supplementing with NAD+ precursor nicotinamide (NAM), Treg frequency increased, ameliorating thrombocytopenia in an ITP murine model. NAM promoted Foxp3 acetylation and stability in induced Tregs, suggesting it as a potential therapeutic strategy for restoring immune balance in ITP. [Extracted from the article]

A study conducted at QILU University of Technology in Jinan, People's Republic of China, focused on the degradation of high-concentration tetracycline (TC) in the environment. The research introduced a method using Fe/N-doped biochar activated by peroxymonosulfate (PMS) to achieve a 90.56% removal efficiency of TC within 60 minutes. The study highlighted the catalytic mechanism of PMS activation through both radical and non-radical pathways, offering a cost-effective and efficient approach to treating high-concentration TC. This research was funded by the National Natural Science Foundation of China and the Talent Research Project of Qilu University of Technology. [Extracted from the article]

A recent study conducted at Shandong University in Jinan, People's Republic of China, focused on the use of biocompatible carbon nanozymes to regulate reactive oxygen species (ROS) balance for treating wounds infected with drug-resistant bacteria. The research demonstrated that the carbon nanozymes could effectively balance ROS generation based on changes in pH at the wound site, leading to successful antimicrobial efficiency against drug-resistant bacteria while minimizing oxidative damage to normal tissues. This study, published in the Chemical Engineering Journal, highlights a promising approach for developing adaptive therapeutic platforms for treating bacterial infections in wounds. [Extracted from the article]

Researchers from QILU University of Technology in Jinan, China, have conducted a study on nanosuspension for improved transdermal targeted drug delivery systems. The research highlights the benefits of nanosuspension, such as high drug loading and improved skin penetration, in enhancing drug absorption and bioavailability. The study emphasizes the potential of nanosuspension technology in transdermal drug delivery and provides insights into future challenges and prospects in this field. This peer-reviewed research offers valuable information for those interested in nanosuspension technology for drug delivery. [Extracted from the article]

Research conducted at Shandong Provincial Hospital in Jinan, China, has explored the protective effects of gastrodin against gentamicin-induced vestibular damage through the Notch signaling pathway. Gentamicin, a commonly used antibiotic, can lead to ototoxicity and balance issues, but gastrodin showed promise in alleviating these impairments in mice. The study highlights the potential of gastrodin as a therapeutic agent for preventing vestibular injuries caused by gentamicin. This research has been peer-reviewed and provides valuable insights into the modulation of the Notch signaling pathway in protecting against drug-induced vestibular dysfunction. [Extracted from the article]

A study conducted at Shandong Jianzhu University in Jinan, China, examined the degradation of Iopamidol (IPM) in the solar/chlorine system. The study found that the solar/chlorine system had a significant effect on the degradation of IPM compared to chlorine alone and solar radiation. Reactive species, such as HO• and reactive chlorine species, played major roles in the degradation process. The study identified the degradation products of IPM and determined that they did not exhibit significant toxicity. The findings suggest that the solar/chlorine system could be used to decompose IPM into non-toxic small molecules. [Extracted from the article]

Researchers at the Shandong Academy of Agricultural Sciences in Jinan, China have conducted a study on the immunomodulatory effects of Lactarius deliciosus, a mushroom known for its taste and texture. The study focused on the polysaccharide extracted from the mushroom and its impact on tumor-bearing mice. The results showed that the polysaccharide had a positive effect on the immune organs of the mice, suppressed tumor growth, and improved intestinal lactobacillus contents. The findings suggest potential applications of Lactarius deliciosus polysaccharide in the food and drug industries. [Extracted from the article]

A report from QILU University of Technology in Jinan, China discusses the efficient removal of non-steroidal anti-inflammatory drugs (NSAIDs) from water systems. The researchers synthesized a magnetic LDH with a three-dimensional hollow structure to remove carprofen and flurbiprofen from water environments. The study found that the adsorption capacity of the synthesized material for the two NSAIDs was high, making it a promising adsorbent for NSAIDs. The research provides valuable insights into the removal of emerging pollutants from aquatic environments. [Extracted from the article]

Researchers at Shandong University in Jinan, China have conducted a study on the impact of miR-137-3p on the pathogenesis of Alzheimer's disease (AD) and developed a novel drug delivery system for its therapeutic potential. The study found that miR-137-3p deficiency is present in both AD cells and animal models. The researchers engineered lipid nanoparticles (LNPs) functionalized with rabies virus glycoprotein to deliver miR-137-3p across the blood-brain barrier and target neurons, resulting in increased miR-137-3p levels in the hippocampus of AD mice. The study suggests that miR-137-3p could be a key factor in AD pathogenesis and a potential avenue for treatment. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, explored the role of autophagy and immunity in Wilms' tumor (WT), a type of malignant tumor. The study aimed to identify differentially expressed immune genes related to autophagy in WT and analyze their correlation with disease prognosis. The researchers found that the plasminogen activator urokinase (PLAU) gene was associated with survival and prognosis in WT patients and could serve as an independent prognostic biomarker. The study also provided insights into the pathways associated with PLAU gene expression, which could be valuable for the development of new therapies for WT. [Extracted from the article]

A study conducted by researchers at the University of Jinan in China has found that a combination of beta-nicotinamide mononucleotide (NMN), Lactobacillus plantarum, and lactulose, known as NMN synbiotics, can have a positive impact on the gut microbiota and metabolism in mice with Alzheimer's disease (AD). The study showed that NMN synbiotics led to a restructuring of the gut microbiota, a reduction in microbial diversity, and a shift towards a more balanced microbial community structure. Additionally, the intervention had a significant impact on the gut metabolome and reduced the formation of amyloid plaques in the brain. These findings suggest that synbiotics could be a potential therapeutic intervention for AD. [Extracted from the article]

Researchers at the University of Jinan in China have developed a method for precisely manipulating steric hindrance in DNA walkers to detect microRNA-21 (miR-21) with tunable dynamic range and sensitivity. By adjusting the length of empty bases and the volumetric dimensions of the hairpin structure, the researchers achieved a tunable limit of detection for miR-21 ranging from 3.6 aM to 35.6 nM, with successful identification of cancer cells and clinical serum samples. This novel strategy has potential applications in personalized medicine, early disease detection, and drug development. The research has been peer-reviewed and published in Analytical Chemistry. [Extracted from the article]

Researchers at QILU University of Technology in Jinan, China have conducted a study on the solubility properties of the antiviral drug Molnupiravir (MPV). The researchers measured the solubility of MPV in 15 different solvents and found that it was highest in cyclohexanone and lowest in ethyl formate. They also used thermodynamic models and molecular simulation techniques to analyze the solubility data and determine the interactions between MPV and the solvents. The results of this study can provide guidance for optimizing the crystallization process of MPV. [Extracted from the article]

A report from the University of Jinan in China discusses the synthesis and evaluation of novel 1,2,3,4-tetrahydrofi-carboline (THfiC) derivatives as potential antibacterial agents. The study aimed to find new antibacterial drugs due to the increasing problem of antibiotic resistance. The researchers synthesized a series of THfiC derivatives and tested their antibacterial activity against both gram-positive and gram-negative bacteria. Some of the compounds showed promising efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and demonstrated rapid bactericidal action. However, one of the compounds also showed significant cytotoxicity towards human cells. The study suggests that THfiC derivatives have potential applications in the development of antibacterial drugs. [Extracted from the article]

A recent study conducted in Jinan, People's Republic of China, has revealed new findings on hernia repair. The study focused on the development of a gel-modified mesh that can effectively address issues such as bacterial infection, postoperative adhesion, and foreign body reaction. The gel-modified mesh, known as the Janus mesh, demonstrated asymmetric performances, with one side maintaining intact gel structures to hinder the stick of proteins and cells, while the other side accelerated degradation to combat bacterial infection. In vivo experiments showed promising results, with no detectable adhesions on the Janus mesh treated group and lower levels of inflammatory response compared to commercial mesh. This research provides a new approach for soft tissue repair biomaterials. [Extracted from the article]

Researchers at QILU University of Technology in Jinan, China have developed bio-based films for potential use as wound dressings. These films incorporate silver nanoparticles (AgNPs) and have high antibacterial properties and low drug resistance. The films also exhibit high UV blocking and antioxidant properties, increased tensile strength, and good biocompatibility. They have shown antibacterial activity against E. coli and S. aureus, making them promising candidates for wound dressings. The research was supported by the Foundation of State Key Laboratory of Biobased Material and Green Papermaking. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital in Jinan, People's Republic of China, examined the effectiveness of piperacillin/tazobactam (PIP/TAZ) in treating lower respiratory tract bacterial infections in children. The study found that the current dosing regimen of PIP/TAZ resulted in subtherapeutic drug concentrations in most children. The researchers concluded that alternative therapies or optimized dosing regimens should be explored. This research was supported by various funding sources, including the National Key R&D Program of China and the National Natural Science Foundation of China. [Extracted from the article]

Researchers from Shandong University in Jinan, People's Republic of China, have conducted a study on anti-infectives. They have developed a bioinspired skeletal reconstruction approach that allows for the synthesis of platensilin, platensimycin, and platencin, which are potential inhibitors of beta-ketoacyl-acyl carrier protein synthase (FabF) in the bacterial and mammalian fatty acid synthesis system. These compounds show promise as drug leads for antibacterial and antidiabetic therapies. The researchers have also prepared analogs with different polycyclic scaffolds, and one of these analogs has demonstrated improved antibacterial activity against S. aureus compared to platensimycin. The study has been published in the Journal of the American Chemical Society. [Extracted from the article]

A recent study conducted at Shandong Provincial Hospital in Jinan, China, focused on esophageal squamous cell carcinoma (ESCC), a common type of cancer with a high fatality rate. The researchers used gene coexpression network analysis to identify genes highly correlated with ESCC and constructed a mitochondria-associated risk (MAR) model. This model revealed differences in immune infiltration and tumor microenvironment characteristics between high- and low-risk populations. The study also explored the effectiveness of different drugs based on the risk group. The researchers concluded that the MAR model could serve as a prognostic biomarker for personalized treatment of ESCC patients. [Extracted from the article]

A study conducted by researchers at Shandong Normal University in Jinan, China, explores the use of a nanoplatform called Fe-MOF to overcome resistance to the chemotherapy drug oxaliplatin in colorectal cancer (CRC) cells. The Fe-MOF nanoplatform delivers both oxaliplatin and a nitric oxide (NO) donor, L-Arginine, to the tumor tissue. This approach depletes glutathione (GSH) in the tumor tissue, enhances the effectiveness of oxaliplatin against drug-resistant CRC, induces apoptosis in CRC cells, and generates reactive nitrogen species for cancer cell destruction. The study suggests that this synergistic strategy could be a promising avenue for enhancing the clinical effectiveness of oxaliplatin in cases resistant to conventional treatment. [Extracted from the article]

Researchers from Shandong Normal University in Jinan, China have developed a new method for detecting Ochratoxin A (OTA) in agricultural products. OTA is a mycotoxin that can pose a serious health risk to humans. The researchers constructed a fluorescent and colorimetric multi-mode aptasensor that can detect OTA with high sensitivity. The aptasensor utilizes G-quadruplex DNAzyme nanostructures and hemin/G4 DNAzymes to produce both a fluorescence signal and a colorimetric signal. The researchers also developed a smartphone-based method for analyzing the signals. This new aptasensor provides a simple and accurate way to detect OTA in real samples, making it a valuable tool for on-site monitoring of OTA in agricultural products. [Extracted from the article]

A recent study conducted at the University of Jinan in Jinan, People's Republic of China, has explored the use of a pyrite/biochar catalyst for the degradation of tetracycline in wastewater treatment. The catalyst, known as FBC, demonstrated high activity and stability in the degradation process over a wide pH range. The study found that the catalyst's surface functional groups and Fe(II)/Fe(III) redox cycling played important roles in the degradation process. The research suggests that this green advanced oxidation technology could be applied to treat pharmaceutical contaminants in real water. [Extracted from the article]

Researchers from QILU University of Technology in Jinan, China have developed a new nanodrug for cancer treatment that combines photothermal therapy (PTT) and chemotherapy. The nanodrug, called DP2, consists of a perylene diimide (PDI) derivative as a photothermal agent and the chemotherapeutic drug DOX. DP2 has a high drug loading capacity and is sensitive to external light and internal lysosome acidic pH. In vitro and in vivo investigations have shown that DP2 has potential applications for dual-mode imaging guided synergistic PTT-chemotherapy. This research has been peer-reviewed and may provide a promising anticancer strategy to maximize therapeutic effects, reverse multidrug resistance, and reduce side effects. [Extracted from the article]

A recent study conducted by researchers at Shandong University of Traditional Chinese Medicine in Jinan, People's Republic of China, has explored the potential of ganoderic acid A (GAA) as a natural neuroprotective agent for neurological disorders. GAA, found in Ganoderma lucidum, has shown promising pharmacological effects and may have therapeutic potential for various neurological disorders. The study suggests that GAA may play a neuroprotective role through mechanisms such as anti-inflammatory, anti-oxidative stress, anti-apoptosis, protection of nerve cells, and regulation of nerve growth factor. This research contributes to the future development of GAA as a potential drug for treating neurological diseases. [Extracted from the article]

A recent report from the Shandong Academy of Agricultural Sciences in Jinan, China discusses the antitumor properties of a component extracted from the root of Croton crassifolius, a traditional Chinese medicine. The study found that a diterpenoid called chettaphanin II showed strong antitumor activity against A549 cells, reducing cell proliferation and inducing apoptosis. The mechanism of action was found to be the obstruction of the mTOR/PI3K/Akt signaling pathway. This research provides evidence for the potential development of anticancer therapies using chettaphanin II. [Extracted from the article]

A study conducted by researchers at Shandong Jianzhu University in Jinan, China, has investigated the retention and transport of the antiviral drug ribavirin in saturated sand and limestone porous media. The study found that ribavirin exhibits strong mobility in saturated quartz sand media and is less affected by hydrochemical factors, posing a high risk of migration. However, in limestone porous media, the migration of ribavirin decreases. The presence of certain ions and humic acid affects the effluent recovery rate of ribavirin. These findings contribute to our understanding of the environmental fate of ribavirin and can aid in ecological restoration efforts. [Extracted from the article]

A report from QILU University of Technology in Jinan, China discusses the use of nanocrystals in drug delivery. The research highlights the importance of nanocrystals in improving the efficacy of insoluble drugs, but notes that current delivery strategies and efficiency still fall short of clinical standards. The study provides a systematic review of nanocrystal-targeting methods and efficiency, as well as the impact of particle size and combination with conventional dosage forms on targeted delivery. The research aims to promote the development of nanocrystal-targeted delivery formulation technology and offers valuable insights for future research in this field. [Extracted from the article]

A study conducted at QILU University of Technology in Jinan, China, has developed a new drug delivery system using hydrogels for movement recovery caused by external injuries. The hydrogels incorporate gallic acid and Fe3+ to generate hydroxyl radicals and accelerate gelation times. These hydrogels have self-healing capabilities, antibacterial properties, and high tensile strength. They also exhibit high sensitivities and rapid response properties, making them suitable for precise monitoring of human movement. The study concludes that this system shows promise for transdermal drug delivery and motion sensing in movement recovery. [Extracted from the article]

Researchers at Shandong University in Jinan, China have made advancements in the biosynthesis of natural products related to obesity, fitness, and wellness. They have identified a single-module nonribosomal peptide synthetase (NRPS) called AstC, which plays a crucial role in the d-alanylation process during the post-polyketide synthase (PKS) modifications of ansatrienin biosynthesis. Through genome mining, the researchers also discovered a newly characterized AstC homolog called SmAstC, which showed high catalytic activity for d-alanylation of N-desmethyl-4,5-desepoxymaytansinol (DDM), a precursor of the antitumor agent ansamitocins. By introducing the gene encoding SmAstC into Actinosynnema pretiosum HGF052, the researchers were able to reprogram the biosynthesis of ansamitocins to produce maytansinol, a critical intermediate of maytansine-derived antibody-drug conjugates. This research has significant implications for the biomanufacturing of maytansinol. [Extracted from the article]

A study conducted by researchers at Shandong University in Jinan, China, focused on the design and synthesis of novel HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). The researchers developed a series of benzo[4,5]thieno[2,3-d]pyrimidine derivatives as potential inhibitors. Compound 16b was found to be the most active inhibitor, showing effectiveness against both wild-type and NNRTI-resistant strains of HIV-1. The compound also demonstrated low cytotoxicity and high selectivity. This research provides a promising lead compound for the development of potent HIV-1 NNRTIs. [Extracted from the article]